Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| local treatment with a corticosteroid-antibiotic preparation in infections of the ear. | 2016 | 4923896 | |
| [v. i. lenin and soviet public health]. | 2016 | 4921776 | |
| [eye manifestations accompanied by brain tumor]. | 2016 | 4921024 | |
| [ideas of lenin and bulgarian medicine]. | 2016 | 4921010 | |
| [surgical treatment of congenital intestinal obstruction in newborns]. | 2016 | 4900634 | |
| bookshelf for the community health nurse specialist. | 2016 | 4908194 | |
| long-term treatment of alcoholism with amitriptyline and emylcamate. a double-blind evaluation. | 2016 | 4860508 | |
| transverse myelopathy as an illustration of the neurologic and neuropathologic features of heroin addiction. | 2016 | 5060674 | |
| [structure of rhamnoconvolvulinic acid (author's transl)]. | 2016 | 4849778 | |
| [thin layer chromatoelectrophretic separation of blood and urinary amino acids]. | 2016 | 4872104 | |
| vertebrate collagen heterogeneity: a brief summary. | 2016 | 4831113 | |
| pyriformsinusosotomy. a useful technique for temporary or permanent tube feeding. | 2016 | 4959520 | |
| [cochleostomy. new surgical treatment of ménière's disease]. | 2016 | 4807358 | |
| isolation of low molecular weight nuclear rna from small numbers of nuclei with cetyltrimethylammonium bromide. | 2016 | 4796083 | |
| accidental hemorrhage. | 2016 | 4792965 | |
| richard morton (1637-1698). | 2016 | 4902031 | |
| [case of pericardiac cyst]. | 2016 | 4856746 | |
| [critical reflections on the concept "drug advertising" regarding the marketing of the drug ponderal (fenfluramine)]. | 2016 | 4774003 | |
| [heart and potassium. electrophysiologic aspects]. | 2016 | 4794438 | |
| [immunological response of the respiratory system to exogenous noxious substances]. | 2016 | 4775913 | |
| [idiopathic exudative gypoproteinemic enteropathy]. | 2016 | 4770066 | |
| [hypertension and nonspecific aortitis of the thoraco-abdominal aorta]. | 2016 | 4775808 | |
| [bronchography. technic using general anesthesia and dual lumen tube]. | 2016 | 4754059 | |
| [state of the tympanic membrane in otosclerosis]. | 2016 | 4763163 | |
| editorial: roots of the women's liberation movement and the practice of medicine. | 2016 | 4744915 | |
| the general practitioner in the accident department. | 2016 | 4731056 | |
| gait disorders in children. | 2016 | 4721953 | |
| interlaboratory quality control using multiple range reference sera and operational lines. | 2016 | 4725001 | |
| basic science departments-inhibitors or catalysts? an allegorical tale. | 2016 | 4831483 | |
| clear and present danger: in childhood meningitis. the importance of hib immunisation in infancy and high-risk groups. | the incidence of haemophilus influenzae type b (hib) invasive disease has declined significantly in the united kingdom since the introduction of routine hib immunisation. however life-threatening hib infections such as meningitis and epiglottitis may still occur, especially in the unimmunised and immigrant children. a case of hib meningitis is a reminder that the threat of invasive hib disease has not been totally eliminated. early diagnosis and treatment of bacterial meningitis (including hib m ... | 2016 | 22685975 |
| occult bacteremia: should we look for the needle in the haystack? | once a well-recognized entity, occult bacteremia (ob) is no longer a significant or serious bacterial infection. first following the introduction of the haemophilus influenzae type b vaccine and now with the implementation of the conjugate pneumococcal vaccine (pcv), the number of cases has declined significantly. this has led to a change in many published guidelines to avoid taking blood cultures in fully vaccinated children presenting with fever. in israel, the introduction of the pcv13 is now ... | 2016 | 28466611 |
| geographic consistency in dominant, non-typeable haemophilus influenzae genotypes colonising four distinct australian paediatric groups: a cohort study. | non-typeable haemophilus influenzae (nthi)-associated ear and respiratory diseases (including pneumonia) represent a major health burden in many parts of the world. nthi strains retrieved from the upper airways commonly reflect those found in the lower airways. despite growing genomic and genotyping data on nthi, there remains a limited understanding of global and regional nthi population structures. the aim of this study was to determine whether nasopharyngeal carriage in four australian paedia ... | 2016 | 28702292 |
| toxicity of macrolide antibiotics on isolated heart mitochondria: a justification for their cardiotoxic adverse effect. | 1. macrolides belong to the polyketide class of natural products. these products are a group of drugs (typically antibiotics) which their activity stems from the presence of a macrolide ring. antibiotic macrolides are used to treat infections caused by gram-positive bacteria and haemophilus influenzae infections such as respiratory tract and soft-tissue infections. macrolides, mainly erythromycin and clarithromycin, rarely show qt prolongation, as their infamous adverse reaction which can lead t ... | 2016 | 26068526 |
| using monte carlo simulation to determine optimal dosing regimen for cefetamet sodium for injection. | the objective of the study was to use monte carlo simulation to determine the optimal treatment dosing regimen of the cefetamet sodium for injection by analysing the pharmacokinetics (pk) parameters in healthy chinese volunteers, and antibacterial activity in vitro was also examined. a three-cross latin square single-dose pk study was designed. twelve healthy volunteers were randomized to receive 500, 1000, and 2000 mg of cefetamet sodium for iv infusion over 30 minutes in three periods sequenti ... | 2016 | 25252727 |
| immunization status of children in foster homes: the first italian data. | the aim of this paper was to evaluate vaccination coverage among children living in forest homes. | 2016 | 24992472 |
| the first reported case of possible haemophilus influenzae type b vaccine failure from kuwait and literature-review. | a 17-month-old vaccinated kuwaiti boy presented with meningitis. the haemophilus influenzae type b (hib) capsular antigen was detected in his blood, csf and urine. the microorganism failed to grow in culture. this case represents the first report of possible hib vaccine failure from kuwait. this report examines the possible reasons for this failure by reviewing the literature and emphasizes the need to broaden the definition of vaccine failure with the aim of optimizing the timing of the vaccine ... | 2016 | 24216517 |
| meninigitis immunisation: challenges, successes and new developments. | meningitis, defined as the inflammation of the lining surrounding the spine and the brain, can be caused by bacteria, viruses and fungi. bacterial meningitis is the most serious form of the disease, causing around 170000 deaths worldwide each year. most cases of bacterial meningitis are caused by three bacteria-streptococcus pneumoniae, neisseria meningitidis and haemophilus influenzae type b. in the uk, vaccines are available to combat most of these, yet, according to the meningitis research fo ... | 2016 | 23299207 |
| [impact of vaccination on admissions for haemophilus influenzae b meningitis from 2004 to 2008 in bobo dioulasso, burkina faso]. | vaccination against haemophilus influenzae type b was introduced in burkina faso on 1st january 2006. this study thus sought to determine the impact of the first 30 months of vaccination on admissions for hib meningitis in the department of pediatrics at the sourô-sanou university hospital in bobo dioulasso. | 2016 | 23360620 |
| ocular penetration of topical antibiotics: study on the penetration of chloramphenicol, tobramycin and netilmicin into the anterior chamber after topical administration. | to compare penetration in the aqueous humour of topically applied antibiotics. | 2016 | 23433257 |
| antibodies from multiple sclerosis patients preferentially recognize hyperglucosylated adhesin of non-typeable haemophilus influenzae. | in autoimmune diseases, there have been proposals that exogenous "molecular triggers", i.e., specific this should be 'non-self antigens' accompanying infectious agents, might disrupt control of the adaptive immune system resulting in serious pathologies. the etiology of the multiple sclerosis (ms) remains unclear. however, epidemiologic data suggest that exposure to infectious agents may be associated with increased ms risk and progression may be linked to exogenous, bacterially-derived, antigen ... | 2016 | 28008952 |
| a novel, molybdenum-containing methionine sulfoxide reductase supports survival of haemophilus influenzae in an in vivo model of infection. | haemophilus influenzae is a host adapted human mucosal pathogen involved in a variety of acute and chronic respiratory tract infections, including chronic obstructive pulmonary disease and asthma, all of which rely on its ability to efficiently establish continuing interactions with the host. here we report the characterization of a novel molybdenum enzyme, torz/mtsz that supports interactions of h. influenzae with host cells during growth in oxygen-limited environments. strains lacking torz/mts ... | 2016 | 27933034 |
| evaluation of an automated system for reading and interpreting disk diffusion antimicrobial susceptibility testing of fastidious bacteria. | results of disk diffusion antimicrobial susceptibility testing depend on individual visual reading of inhibition zone diameters. therefore, automated reading using camera systems might represent a useful tool for standardization. in this study, the adagio automated system (bio-rad) was evaluated for reading disk diffusion tests of fastidious bacteria. 144 clinical isolates (68 β-haemolytic streptococci, 28 streptococcus pneumoniae, 18 viridans group streptococci, 13 haemophilus influenzae, 7 mor ... | 2016 | 27391898 |
| chloramphenicol derivatives as antibacterial and anticancer agents: historic problems and current solutions. | chloramphenicol (cam) is the d-threo isomer of a small molecule, consisting of a p-nitrobenzene ring connected to a dichloroacetyl tail through a 2-amino-1,3-propanediol moiety. cam displays a broad-spectrum bacteriostatic activity by specifically inhibiting the bacterial protein synthesis. in certain but important cases, it also exhibits bactericidal activity, namely against the three most common causes of meningitis, haemophilus influenzae, streptococcus pneumoniae and neisseria meningitidis. ... | 2016 | 27271676 |
| hib vaccines: past, present, and future perspectives. | haemophilus influenzae type b (hib) causes many severe diseases, including epiglottitis, pneumonia, sepsis, and meningitis. in developed countries, the annual incidence of meningitis caused by bacteria is approximately 5-10 cases per population of 100,000. the hib conjugate vaccine is considered protective and safe. adjuvants, molecules that can enhance and/or regulate the fundamental immunogenicity of an antigen, comprise a wide range of diverse compounds. while earlier developments of adjuvant ... | 2016 | 26904695 |
| effects of aspartic acid, orotic acid, and glucose on serum bilirubin concentrations in infants born before term. | 2016 | 4929236 | |
| [health and sanitary considerations on the use of the pesticide dipterex]. | 2016 | 4742705 | |
| [coffee and health: the place of coffee in dietetics]. | 2016 | 5042080 | |
| [bone marrow transplantation]. | 2016 | 4944776 | |
| [involutive cerebral disorders in old age. 3. horn of ammon]. | 2016 | 4783338 | |
| [diagnostic rapid tests used in practice]. | 2016 | 4745912 | |
| studies of attention and seizure disorders. | 2016 | 4718693 | |
| [aneurysmal dilatation of the left atrium without pericardial dehiscence]. | 2016 | 4718540 | |
| blastogenic transformation of lymphocytes following phytohaemagglutinin treatment in vitro in malignant lymphomas. 3. chronic lymphatic leukaemia. | 2016 | 4702206 | |
| triglyceride fatty acids of selected higher marine fungi. | 2016 | 4712320 | |
| the diagnosis and treatment of meningitis. | 2016 | 4716228 | |
| the effects of edge sharpness and exposure duration on detection threshold. | 2016 | 4706349 | |
| a histological and kinetic study of an ileal conduit. | 2016 | 4700418 | |
| aspirin and the kidney. | 2016 | 4944327 | |
| arthur melvin townsend, jr., a. b., m.d., 1903-1971. | 2016 | 4943153 | |
| two scope technique for the transrectal removal of lesions high in the rectum and sigmoid colon. | 2016 | 4759795 | |
| identification and characterization of msf, a novel virulence factor in haemophilus influenzae. | haemophilus influenzae is an opportunistic pathogen. the emergence of virulent, non-typeable strains (nthi) emphasizes the importance of developing new interventional targets. we screened the nthi supragenome for genes encoding surface-exposed proteins suggestive of immune evasion, identifying a large family containing sel1-like repeats (slrs). clustering identified ten slr-containing gene subfamilies, each with various numbers of slrs per gene. individual strains also had varying numbers of slr ... | 2016 | 26977929 |
| structural basis of thiol-based regulation of formaldehyde detoxification in h. influenzae by a merr regulator with no sensor region. | pathogenic bacteria such as haemophilus influenzae, a major cause of lower respiratory tract diseases, must cope with a range of electrophiles generated in the host or by endogenous metabolism. formaldehyde is one such compound that can irreversibly damage proteins and dna through alkylation and cross-linking and interfere with redox homeostasis. its detoxification operates under the control of hinmlr, a protein from the merr family that lacks a specific sensor region and does not bind metal ion ... | 2016 | 27307602 |
| the use of pcr/electrospray ionization-time-of-flight-mass spectrometry (pcr/esi-tof-ms) to detect bacterial and fungal colonization in healthy military service members. | the role of microbial colonization in disease is complex. novel molecular tools to detect colonization offer theoretical improvements over traditional methods. we evaluated pcr/electrospray ionization-time-of-flight-mass spectrometry (pcr/esi-tof-ms) as a screening tool to study colonization of healthy military service members. | 2016 | 27448413 |
| real-time qpcr improves meningitis pathogen detection in invasive bacterial-vaccine preventable disease surveillance in fiji. | as part of the world health organization invasive bacterial-vaccine preventable diseases (ib-vpd) surveillance in suva, fiji, cerebrospinal fluid (csf) samples from suspected meningitis patients of all ages were examined by traditional methods (culture, gram stain, and latex agglutination for bacterial antigen) and qpcr for streptococcus pneumoniae, neisseria meningitidis, and haemophilus influenzae. of 266 samples tested, pathogens were identified in 47 (17.7%). s. pneumoniae was the most commo ... | 2016 | 28009001 |
| expression of the gene for autotransporter autb of neisseria meningitidis affects biofilm formation and epithelial transmigration. | neisseria meningitidis is a gram-negative bacterium that resides as a commensal in the upper respiratory tract of humans, but occasionally, it invades the host and causes sepsis and/or meningitis. the bacterium can produce eight autotransporters, seven of which have been studied to some detail. the remaining one, autb, has not been characterized yet. here, we show that the autb gene is broadly distributed among pathogenic neisseria spp. the gene is intact in most meningococcal strains. however, ... | 2016 | 27921012 |
| nationwide trends in bacterial meningitis before the introduction of 13-valent pneumococcal conjugate vaccine-burkina faso, 2011-2013. | following introduction of haemophilus influenzae type b vaccine in 2006 and serogroup a meningococcal conjugate vaccine in 2010, streptococcus pneumoniae (sp) became the leading cause of bacterial meningitis in burkina faso. we describe bacterial meningitis epidemiology, focusing on pneumococcal meningitis, before 13-valent pneumococcal conjugate vaccine (pcv13) introduction in the pediatric routine immunization program in october 2013. | 2016 | 27832151 |
| immunoinformatics approach in designing epitope-based vaccine against meningitis-inducing bacteria (streptococcus pneumoniae, neisseria meningitidis, and haemophilus influenzae type b). | meningitis infection is one of the major threats during hajj season in mecca. meningitis vaccines are available, but their uses are limited in some countries due to religious reasons. furthermore, they only give protection to certain serogroups, not to all types of meningitis-inducing bacteria. recently, research on epitope-based vaccines has been developed intensively. such vaccines have potential advantages over conventional vaccines in that they are safer to use and well responded to the anti ... | 2016 | 27812281 |
| an outbreak of pneumococcal meningitis among older children (≥5 years) and adults after the implementation of an infant vaccination programme with the 13-valent pneumococcal conjugate vaccine in ghana. | an outbreak of pneumococcal meningitis among non-infant children and adults occurred in the brong-ahafo region of ghana between december 2015 and april 2016 despite the recent nationwide implementation of a vaccination programme for infants with the 13-valent pneumococcal conjugate vaccine (pcv13). | 2016 | 27756235 |
| the epidemiology of meningitis among adults in a south african province with a high hiv prevalence, 2009-2012. | meningitis is a major cause of mortality in southern africa. we aimed to describe the aetiologies and frequencies of laboratory-confirmed fungal and bacterial meningitis among adults in a south african province with an 11% hiv prevalence, over 4 years. | 2016 | 27669564 |
| evaluation of pastorex meningitis kit performance for the rapid identification of neisseria meningitidis serogroup c in nigeria. | neisseria meningitidis serogroup c (nmc) has caused outbreaks in nigeria of increasing size in three consecutive years since 2013. rapid diagnostic tests (rdts) for meningitis can facilitate quick identification of the causative pathogen; pastorex can detect n. meningitidis serogroups a, c (nmc), y/w135, n. meningitidis serogroup b/escherichia coli k1, haemophilus influenzae type b (hib), streptococcus pneumoniae, and group b streptococcus. there is no published field evaluation of pastorex in t ... | 2016 | 27496511 |
| identification of common bacterial pathogens causing meningitis in culture-negative cerebrospinal fluid samples using real-time polymerase chain reaction. | background. meningitis is a serious communicable disease with high morbidity and mortality rates. it is an endemic disease in egypt caused mainly by streptococcus pneumoniae, neisseria meningitidis, and haemophilus influenzae. in some settings, bacterial meningitis is documented depending mainly on positive cerebrospinal fluid (csf) culture results or csf positive latex agglutination test, missing the important role of prior antimicrobial intake which can yield negative culture and latex aggluti ... | 2016 | 27563310 |
| assessing sex-differences and the effect of timing of vaccination on immunogenicity, reactogenicity and efficacy of vaccines in young children: study protocol for an individual participant data meta-analysis of randomised controlled trials. | disease incidence differs between males and females for some infectious or inflammatory diseases. sex-differences in immune responses to some vaccines have also been observed, mostly to viral vaccines in adults. little evidence is available on whether sex-differences occur in response to immunisation in infancy even though this is the age group in which most vaccines are administered. factors other than sex, such as timing or coadministration of other vaccines, can also influence the immune resp ... | 2016 | 27473951 |
| antibody persistence in young children 5 years after vaccination with a combined haemophilus influenzae type b-neisseria meningitidis serogroup c conjugate vaccine coadministered with diphtheria-tetanus-acellular pertussis-based and pneumococcal conjugate vaccines. | we evaluated antibody persistence in children up to 5 years after administration of a combined haemophilus influenzae type b (hib)-neisseria meningitidis serogroup c (menc)-tetanus toxoid (tt) conjugate vaccine coadministered with a pneumococcal conjugate vaccine. this is the follow-up study of a randomized trial (clinicaltrials.gov registration no. nct00334334/00463437) in which healthy children were vaccinated (primary vaccinations at 2, 4, and 6 months of age and booster vaccination at 11 to ... | 2016 | 27145999 |
| a glycoconjugate of haemophilus influenzae type b capsular polysaccharide with tetanus toxoid protein: hydrodynamic properties mainly influenced by the carbohydrate. | three important physical properties which may affect the performance of glycoconjugate vaccines against serious disease are molar mass (molecular weight), heterogeneity (polydispersity), and conformational flexibility in solution. the dilute solution behaviour of native and activated capsular polyribosylribitol (prp) polysaccharides extracted from haemophilus influenzae type b (hib), and the corresponding glycoconjugate made by conjugating this with the tetanus toxoid (tt) protein have been char ... | 2016 | 26915577 |
| development of real-time pcr methods for the detection of bacterial meningitis pathogens without dna extraction. | neisseria meningitidis (nm), haemophilus influenzae (hi), and streptococcus pneumoniae (sp) are the lead causes of bacterial meningitis. detection of these pathogens from clinical specimens using traditional real-time pcr (rt-pcr) requires dna extraction to remove the pcr inhibitors prior to testing, which is time consuming and labor intensive. in this study, five species-specific (nm-sodc and -ctra, hi-hpd#1 and -hpd#3 and sp-lyta) and six serogroup-specific rt-pcr tests (a, b, c, w, x, y) targ ... | 2016 | 26829233 |
| prevention and control of childhood pneumonia and diarrhea. | pneumonia and diarrhea are the 2 leading infectious causes of death in children younger than 5 years worldwide, most of which occur in low- and middle-income countries (lmics) in sub-saharan africa and southern asia. the past decade has seen large reductions in global childhood mortality, partly due to expansion of nonspecific public health interventions and vaccines against streptococcus pneumoniae, haemophilus influenzae, and rotavirus in lmics. further progress in this field depends on the in ... | 2016 | 26613689 |
| naturally acquired hmw1- and hmw2-specific serum antibodies in adults and children mediate opsonophagocytic killing of nontypeable haemophilus influenzae. | the hmw1 and hmw2 proteins are highly immunogenic adhesins expressed by approximately 75% of nontypeable haemophilus influenzae (nthi) strains, and hmw1- and hmw2-specific antibodies can mediate opsonophagocytic killing of nthi. in this study, we assessed the ability of hmw1- and hmw2-specific antibodies in sera from healthy adults and convalescent-phase sera from children with nthi otitis media to mediate killing of homologous and heterologous nthi. the serum samples were examined pre- and post ... | 2016 | 26512048 |
| clinical features and outcomes of ipf patients hospitalized for pulmonary infection: a japanese cohort study. | many patients with idiopathic pulmonary fibrosis (ipf) undergo hospitalizations due to pulmonary infections. we retrospectively investigated the characteristics of hospitalizations due to pulmonary infection in patients with ipf to elucidate causative pathogens and mortality. we reviewed patients with ipf who were admitted between january 2008 and december 2014 for pulmonary infections including pneumonia and bronchitis. the causative pathogen, the relationship between the site of pneumonia and ... | 2016 | 27959904 |
| increased nasopharyngeal density and concurrent carriage of streptococcus pneumoniae, haemophilus influenzae, and moraxella catarrhalis are associated with pneumonia in febrile children. | we assessed nasopharyngeal (np) carriage of five pathogens in febrile children with and without acute respiratory infection (ari) of the upper (urti) or lower tract, attending health facilities in tanzania. | 2016 | 27907156 |
| oldenlandia diffusa extract inhibits biofilm formation by haemophilus influenzae clinical isolates. | oldenlandia diffusa has been empirically used as a therapeutic adjunct for the treatment of respiratory infections. to establish the basic evidence of its clinical usefulness, antimicrobial and biofilm inhibitory activities of an o. diffusa extract were examined against clinical isolates of haemophilus influenzae, a major causative pathogen of respiratory and sensory organ infections. no significant growth inhibitory activity was observed during incubation for more than 6 h after the extract add ... | 2016 | 27902758 |
| microbiological features of upper respiratory tract infections in bulgarian children for the period 1998-2014. | across the globe, upper respiratory tract infections (urtis) are the most prevalent cause of morbidity in childhood. | 2016 | 27994923 |
| respiratory microbes present in the nasopharynx of children hospitalised with suspected pulmonary tuberculosis in cape town, south africa. | lower respiratory tract infection in children is increasingly thought to be polymicrobial in origin. children with symptoms suggestive of pulmonary tuberculosis (ptb) may have tuberculosis, other respiratory tract infections or co-infection with mycobacterium tuberculosis and other pathogens. we aimed to identify the presence of potential respiratory pathogens in nasopharyngeal (np) samples from children with suspected ptb. | 2016 | 27776489 |
| c-reactive protein in outpatients with acute exacerbation of copd: its relationship with microbial etiology and severity. | c-reactive protein (crp) measurement has proven valuable for detecting exacerbations, but its usefulness in predicting etiology remains controversial. likewise, its potential value as a marker of severity, which is well established in patients with pneumonia, remains unproven in chronic obstructive pulmonary disease (copd) exacerbations. | 2016 | 27799762 |
| nasal carriage of common bacterial pathogens among healthy kindergarten children in chaoshan region, southern china: a cross-sectional study. | nasal colonization with bacterial pathogens is associated with risk of invasive respiratory tract infections, but the related information for chinese healthy children is scarce. | 2016 | 27741941 |
| changes in the prevalence and biofilm formation of haemophilus influenzae and haemophilus parainfluenzae from the respiratory microbiota of patients with sarcoidosis. | healthy condition and chronic diseases may be associated with microbiota composition and its properties. the prevalence of respiratory haemophili with respect to their phenotypes including the ability to biofilm formation in patients with sarcoidosis was assayed. | 2016 | 27562460 |
| discovery and analysis of natural-product compounds inhibiting protein synthesis in pseudomonas aeruginosa. | bacterial protein synthesis is the target for numerous natural and synthetic antibacterial agents. we have developed a poly(u) mrna-directed aminoacylation/translation (a/t) protein synthesis system composed of phenylalanyl-trna synthetases (phers), ribosomes, and ribosomal factors from pseudomonas aeruginosa this system has been used for high-throughput screening of a natural-compound library. assays were developed for each component of the system to ascertain the specific target of inhibitory ... | 2016 | 27246774 |
| early-life intranasal colonization with nontypeable haemophilus influenzae exacerbates juvenile airway disease in mice. | accumulating evidence suggests a connection between asthma development and colonization with nontypeable haemophilus influenzae (nthi). specifically, nasopharyngeal colonization of human infants with nthi within 4 weeks of birth is associated with an increased risk of asthma development later in childhood. monocytes derived from these infants have aberrant inflammatory responses to common upper respiratory bacterial antigens compared to those of cells derived from infants who were not colonized ... | 2016 | 27113355 |
| monoclonal antibodies against dna-binding tips of dnabii proteins disrupt biofilms in vitro and induce bacterial clearance in vivo. | the vast majority of chronic and recurrent bacterial diseases are attributed to the presence of a recalcitrant biofilm that contributes significantly to pathogenesis. as such, these diseases will require an innovative therapeutic approach. we targeted dnabii proteins, an integral component of extracellular dna (edna) which is universally found as part of the pathogenic biofilm matrix to develop a biofilm disrupting therapeutic. we show that a cocktail of monoclonal antibodies directed against sp ... | 2016 | 27342872 |
| associations between nasopharyngeal carriage of group b streptococcus and other respiratory pathogens during early infancy. | in west africa, the carriage of group b streptococcus (gbs), among infants is poorly characterised. we investigated co-carriage of gbs with other respiratory pathogens in the infants' nasopharynx in the gambia. | 2016 | 27230066 |
| development of upper respiratory tract microbiota in infancy is affected by mode of delivery. | birth by caesarian section is associated with short- and long-term respiratory morbidity. we hypothesized that mode of delivery affects the development of the respiratory microbiota, thereby altering its capacity to provide colonization resistance and consecutive pathobiont overgrowth and infections. therefore, we longitudinally studied the impact of mode of delivery on the nasopharyngeal microbiota development from birth until six months of age in a healthy, unselected birth cohort of 102 child ... | 2016 | 27333043 |
| microbiological characterization of haemophilus influenzae isolated from patients with lower respiratory tract infections in a tertiary care hospital, south india. | haemophilus influenzae is responsible for wide range of localized and invasive lower respiratory tract infections (lrti) with the highest burden of disease in low and middle income countries. | 2016 | 27437218 |
| effectiveness of the 10-valent pneumococcal nontypeable haemophilus influenzae protein d-conjugated vaccine (phid-cv) against carriage and acute otitis media-a double-blind randomized clinical trial in finland. | after administering the 10-valent pneumococcal polysaccharide nontypeable haemophilus influenzae protein d-conjugated vaccine (phid-cv) to children aged 2-18 months, we observed a reduction in vaccine-type nasopharyngeal carriage, resulting in a reduction of overall pneumococcal nasopharyngeal carriage, which may be important for indirect vaccine effects. we noted a trend toward reduction of acute otitis media. | 2016 | 27125273 |
| defining the binding region in factor h to develop a therapeutic factor h-fc fusion protein against non-typeable haemophilus influenzae. | non-typeable haemophilus influenzae (nthi) cause a range of illnesses including otitis media, sinusitis, and exacerbation of chronic obstructive pulmonary disease, infections that contribute to the problem of antibiotic resistance and are themselves often intractable to standard antibiotic treatment regimens. we investigated a strategy to exploit binding of the complement inhibitor factor h (fh) to nthi as a functional target for an immunotherapeutic containing the nthi binding domain of fh fuse ... | 2016 | 27148489 |
| retrospective analysis of the microbiological spectrum of pneumonia in turkish patients with lung cancer. | the spectrum of pulmonary infections in patients with lung cancer is wide, and tools for target-oriented infection control measures are necessary. in this retrospective study we report the microbiological spectrum of pneumonia (based on the results of sputum culture) in a case series of turkish patients with lung malignancies. | 2016 | 27095942 |
| predominant bacteria detected from the middle ear fluid of children experiencing otitis media: a systematic review. | otitis media (om) is amongst the most common childhood diseases and is associated with multiple microbial pathogens within the middle ear. global and temporal monitoring of predominant bacterial pathogens is important to inform new treatment strategies, vaccine development and to monitor the impact of vaccine implementation to improve progress toward global om prevention. | 2016 | 26953891 |
| in vitro activity of gepotidacin, a novel triazaacenaphthylene bacterial topoisomerase inhibitor, against a broad spectrum of bacterial pathogens. | gepotidacin inhibits bacterial dna replication through a mode different from that of fluoroquinolones. gepotidacin and comparators were tested by broth and agar dilution against clinical isolates. the in vitro activities of gepotidacin were comparable against methicillin-susceptible and -resistant staphylococcus aureus (mssa and mrsa, respectively) isolates (mic90, 0.5 μg/ml). the gepotidacin mic90s were as follows (in micrograms per milliliter) for the indicated bacteria: streptococcus pyogenes ... | 2016 | 26729499 |
| a novel mechanism for the biogenesis of outer membrane vesicles in gram-negative bacteria. | bacterial outer membrane vesicles (omvs) have important biological roles in pathogenesis and intercellular interactions, but a general mechanism of omv formation is lacking. here we show that the vacj/yrb abc (atp-binding cassette) transport system, a proposed phospholipid transporter, is involved in omv formation. deletion or repression of vacj/yrb increases omv production in two distantly related gram-negative bacteria, haemophilus influenzae and vibrio cholerae. lipidome analyses demonstrate ... | 2016 | 26806181 |
| an independent evaluation of a novel peptide mimetic, brilacidin (pmx30063), for ocular anti-infective. | brilacidin (bri), a novel defensin mimetic, was evaluated as an ocular anti-infective. | 2016 | 26501484 |
| a new model for non-typeable haemophilus influenzae middle ear infection in the junbo mutant mouse. | acute otitis media, inflammation of the middle ear, is the most common bacterial infection in children and, as a consequence, is the most common reason for antimicrobial prescription to this age group. there is currently no effective vaccine for the principal pathogen involved, non-typeable haemophilus influenzae (nthi). the most frequently used and widely accepted experimental animal model of middle ear infection is in chinchillas, but mice and gerbils have also been used. we have established a ... | 2016 | 26611891 |
| ceftaroline activity tested against bacterial isolates causing community-acquired respiratory tract infections and skin and skin structure infections in pediatric patients from united states hospitals: 2012-2014. | ceftaroline fosamil has recently received united states food and drug administration (us-fda) approval for treatment of acute bacterial skin/skin structure infections (sssi), including those caused by methicillin-resistant staphylococcus aureus (mrsa) and community-acquired bacterial pneumonia for pediatric patients ≥2 months old. we evaluated the potency and spectrum of ceftaroline and comparators when tested against community-acquired respiratory tract (carti) and sssi pathogens from pediatric ... | 2016 | 27977560 |