Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| tissue microarray (tma) analysis of normal and persistent chlamydophila pneumoniae infection. | chlamydophila pneumoniae infection has been implicated as a potential risk factor for atherosclerosis, however the mechanism leading to persistent infection and its role in the disease process remains to be elucidated. | 2006 | 17052347 |
| localization of the hypothetical protein cpn0797 in the cytoplasm of chlamydia pneumoniae-infected host cells. | using antibodies raised with chlamydial fusion proteins, we have localized a protein encoded by the hypothetical open reading frame cpn0797 in the cytoplasm of chlamydia pneumoniae-infected host cells. the anti-cpn0797 antibodies specifically recognized cpn0797 protein without cross-reacting with either cpafcp or cpn0796, the only two proteins known to be secreted into the host cell cytosol by c. pneumoniae organisms. thus, cpn0797 represents the third c. pneumoniae protein secreted into the hos ... | 2006 | 17057097 |
| global transcriptional upregulation in the absence of increased translation in chlamydia during ifngamma-mediated host cell tryptophan starvation. | the developmentally regulated intracellular pathogen chlamydia pneumoniae is a natural tryptophan auxotroph. these organisms survive tryptophan starvation induced by host cell activation with ifngamma by blocking maturation to the infectious form. in most bacteria, the stringent response is induced during amino acid starvation to promote survival. however, the response of obligate intracellular pathogens, which are predicted to lack stringent responses to amino acid starvation, is poorly charact ... | 2006 | 17059564 |
| outbreak of respiratory tract infections on an islet in korea: possible chlamydia pneumoniae infection. | in march 2004, we experienced an outbreak of chlamydia pneumoniae infection on an islet of korea. in order to assess the significance of the epidemic, we performed a mass examination of 137 students (7-16 years old; male, 69; female, 58) at a school. the examination consisted of a questionnaire inquiring about respiratory symptoms, a serum antibody test for c. pneumoniae using a microimmunofluorescence (mif) method and enzyme-linked immunosorbent assay (elisa), and nasopharyngeal swab tests to d ... | 2006 | 17060694 |
| effect of clarithromycin on cytokines and chemokines in children with an acute exacerbation of recurrent wheezing: a double-blind, randomized, placebo-controlled trial. | clarithromycin is postulated to possess immunomodulatory properties in addition to its antimicrobial activity. | 2006 | 17069099 |
| a role for archaeal organisms in development of atherosclerotic vulnerable plaques and myxoid matrices. | vulnerable plaques are characterized by a myxoid matrix, necrotic lipidic core, reactive oxygen species, and high levels of microorganisms. aerobic microbes such as chlamydophila pneumoniae and mycoplasma pneumoniae usually do not survive in oxidative stress media. archaea are anaerobic microbes with powerful anti-oxidative enzymes that allow detoxification of free radicals whose presence might favor the survival of aerobic microorganisms. we searched for archaeal organisms in vulnerable plaques ... | 2006 | 17072447 |
| chlamydia pneumoniae replicates in kupffer cells in mouse model of liver infection. | to develop an animal model of liver infection with chlamydia pneumoniae (c. pneumoniae) in intraperitoneally infected mice for studying the presence of chlamydiae in kupffer cells and hepatocytes. | 2006 | 17072977 |
| outbreak of chlamydia pneumoniae infection in a japanese nursing home, 1999-2000. | to identify risk factors for infection and severe illness due to chlamydia pneumoniae. | 2006 | 17080373 |
| both hepatitis c virus and chlamydia pneumoniae infection are related to the progression of carotid atherosclerosis in patients undergoing lipid lowering therapy. | recent experimental and epidemiological findings suggest that infectious agents may play a role in the development and progression of atherosclerosis. we previously reported that chlamydia pneumoniae (c. pneumoniae) infection reduces the effectiveness of lipid-lowering therapy for carotid atherosclerosis and that this micro-organism may play a role in the progression of atherosclerosis. in this study, we investigated the possible association between hepatitis c virus (hcv) infection and carotid ... | 2006 | 17087362 |
| [atherosclerosis and infection?]. | atherosclerosis is guided by chronicle inflammation process. in the last decades of the 20th century, studies considering infection another possible risk factor of atherosclerosis development were written. helicobacter pylori, porphyromas gingivalis, some viruses but most frequently chlamydia pneumonie are infection agens mentioned in these studies. some of them emphasize also combined infections caused by more pathogenic factors having influence on vascular inflammation. serological, epidemiolo ... | 2006 | 17091609 |
| 13--antibiotic therapy of community-acquired pneumonia (cap) caused by atypical agents. | macrolides, fluoroquinolones, doxycycline, and ketolides show a good intrinsic activity against intracellular pathogens which are responsible for a variable percentage of community-acquired pneumonia (cap). these therapeutic agents all seem effective in treating most cases of cap caused by mycoplasma pneumoniae, chlamydia pneumoniae, or legionella spp. among quinolones, the more recent fluoroquinolones, such as gemifloxacin or moxifloxacin, generally show a better intrinsic activity than the old ... | 2006 | 17095177 |
| re: "antibiotic use and risk of multiple sclerosis". | 2006 | 17095537 | |
| bacterial diversity in aortic aneurysms determined by 16s ribosomal rna gene analysis. | aortic aneurysms are common vascular conditions that cause considerable morbidity and mortality. understanding of the mechanisms involved in the pathogenesis of the condition remains limited. recently, infection has been suggested as possible contributor in the development of the disease. the aim of the present study was to examine aortic aneurysms for the presence of bacterial dna using polymerase chain reaction (pcr) targeting the 16s ribosomal rna (rrna) gene, followed by cloning and sequenci ... | 2006 | 17098542 |
| prevalence and clinical presentations of atypical pathogens infection in community acquired pneumonia in thailand. | to determine the prevalence of atypical pneumonia and clinical presentations in patients with community acquired pneumonia (cap). | 2006 | 17100378 |
| activators of plasminogen and the progression of small abdominal aortic aneurysms. | the aim of this study was to examine the role of activating pathways of plasminogen in the natural history of abdominal aortic aneurysms (aaa). to fulfill this objective 70 male patients with small aaa (> 3 cm) were interviewed and examined. their blood samples were taken at diagnosis. the patients were scanned annually for a minimum period of 1 year and a maximum of 5 years (mean 2.5 years), and referred for surgery if the aaa exceeded 5 cm in diameter. plasma levels of urokinase-like plasminog ... | 2006 | 17182930 |
| [erythema multiforme majus and chlamydia pneumoniae infection]. | erythema multiforme majus of infectious origin is an acute eruptive syndrome seen more commonly in young subjects and characterised by an appearance of round target lesions. in most cases, it is associated with infection involving herpes simplex virus or mycoplasma pneumoniae. we report an original case of erythema multiforme majus subsequent to infection with chlamydia pneumoniae. | 2006 | 17185933 |
| [chlamydophila pneumoniae biotype twar: selected details]. | chlamydophila pneumoniae biotype twar is classified in the chlamydiacea family and used to be considered a cause of pneumonia. lately it has been also proved that it can cause heart disease and diseases of the blood vessels and also take part in the pathogenesis alzheimer and multiple sclerosis, which shows that biotype twar has expanded its spectrum. | 2006 | 17199102 |
| chlamydophila pneumoniae in horses: a seroepidemiological survey in italy. | we tested 731 sera from apparently healthy light horses against chlamydophila pneumoniae, by a microimmuno-fluorescence (mif) test. to verify cross-reactions with other species of chlamvdiae, all sera with an antibody titre > or = 32 to c. pneumoniae were tested against both c. psittaci and c. abortus. antibodies to c. pneumoniae were detected in 194 out of 731 (26.5%) samples tested, with antibody titres ranging from 32 to 1024. no antibody titre > or = 32 was detected in sera to c. abortus. on ... | 2006 | 17201097 |
| antimicrobial symposium. part iv. cephalosporins. | 2006 | 17310925 | |
| [rupture of the atherosclerotic plaque: is chlamydia pneumoniae a possible agent?]. | the natural history of atherosclerosis has not clearly been elucidated yet. some works reported that flogosis plays a role in plaque instability. why does this inflammatory process start? we investigated the correlation between chlamydia pneumoniae acute infection and plaque rupture. | 2006 | 17294605 |
| [sero-epidemiologic study on the relationship between chlamydia pneumonia infection and hypertension in chinese mongolian population]. | to explore the relationship between chlamydia pneumonia (cp) infection and hypertension as well as the interaction of traditional risk factors and cp infections on hypertension in chinese mongolian population. | 2006 | 17343175 |
| [chlamydia pneumoniae occurrence in children with adenoid vegetations]. | in world literature there is a lack on informations about occurrence frequency of chlamydia pneumoniae in swabs fromadenoid vegetations. chlamydia spp. is a group of nontypical pathogenetic bacteria. initially they were fought a cause of lower respiratory tract. nowadays they are considered as a pathogenetic factor of upper respiratory tract infections. they can also cause persistant infection. | 2006 | 17357663 |
| detection of helicobacter pylori and chlamydia pneumoniae genes in primary orbital lymphoma. | primary orbital non-hodgkin's lymphoma is a mucosa-associated lymphoid tissue (malt)-type extranodal marginal zone lymphoma. chronic antigen stimulation is implicated as a causative agent in the development of some mature b-cell proliferations; for example, there are associations involving helicobacter pylori with gastric or conjunctival malt lymphoma and chlamydia psittaci with ocular adnexal lymphoma. we examined the molecular signatures of h pylori and chlamydia in eight orbital lymphomas. | 2006 | 17471326 |
| chlamydial heat-shock protein 60 : a marker for chronic infection with chlamydia pneumoniae in atherosclerosis: investigation of atherosclerotic coronary arteries by immunocytochemistry. | worldwide, ischemic heart disease is an important cause of death and there is an increasing number of pointers toward a causative connection between chlamydia pneumoniae and atherosclerosis. the presence, localization, and relationship to atheroma of chlamydial heat-shock protein 60 (chsp60) in coronary tissue was investigated by immunocytochemical methods and by different investigators. in the present study, for the first time, arterial segments, including the whole course of the great coronary ... | 2006 | 25868695 |
| serological evidence of chronic chlamydia pneumoniae infection in coronary artery disease. | recent studies have suggested that chlamydia pneumoniae infection could be involved in atherosclerosis and related clinical manifestations such as coronary artery disease, carotid artery stenosis and myocardial infarction. | 2007 | 27408004 |
| optimization of a polymerase chain reaction (pcr) for increasing its sensitivity to detect chlamydia pneumoniae specific genome. | being an intracellular parasite, chlamydia pneumoniae disseminates to organs outside the respiratory tract and causes chronic diseases in human. nucleic acid-based method such as polymerase chain reaction (pcr) as diagnostic test has greater sensitivity and specificity than conventional microbiological techniques. the pcr protocol consisting of touchdown technique to detect c. pneumoniae dna using major outer membrane protein gene (momp) was carried out in our laboratory as described in referenc ... | 2007 | 17474277 |
| the role of pulmonary infection in pediatric asthma. | recently, several authors have documented that respiratory infections may cause wheezing and acute exacerbation of asthma in children. respiratory syncytial virus infections have been recognized to produce the first episode of wheezing in children who go on to develop chronic asthma. furthermore, repeated infections caused by other common childhood viral pathogens have been proposed to affect responses of the immune system in such a way as to prevent the onset of allergic diseases and possibly a ... | 2007 | 17479603 |
| socioeconomic status, pathogen burden and cardiovascular disease risk. | socioeconomic status (ses) is inversely associated with coronary heart disease (chd) risk. cumulative pathogen burden may also predict future chd. the hypothesis was tested that lower ses is associated with a greater pathogen burden, and that pathogen burden accounts in part for ses differences in cardiovascular risk factors. | 2007 | 17488763 |
| chlamydia pneumoniae directly interferes with hif-1alpha stabilization in human host cells. | chlamydiaceae are obligate intracellular bacteria that cause endemic trachoma, sexually transmitted diseases and respiratory infections. the course of the diseases is determined by local inflammatory immune responses and the propensity of the pathogen to replicate within infected host cells. both features require energy which is inseparably coupled to oxygen availability in the microenvironment. hypoxia-inducible factor-1 (hif-1) regulates crucial genes involved in the adaptation to low oxygen c ... | 2007 | 17490410 |
| [chlamydial pneumonia]. | 2007 | 17494169 | |
| enterovirus in arteriosclerosis: a pilot study. | various pathogens have been suspected to play a role in the initiation or amplification of the atherosclerotic lesions. both experimental and epidemiological arguments plead for a possible role of enterovirus in this process. | 2007 | 17499019 |
| characterization of hypothetical proteins cpn0146, 0147, 0284 & 0285 that are predicted to be in the chlamydia pneumoniae inclusion membrane. | although more than 100 chlamydia pneumoniae hypothetical proteins have been predicted to be inclusion membrane proteins, only a few have been experimentally demonstrated to be in the inclusion membrane. using antibodies raised with fusion proteins, we characterized four such hypothetical proteins encoded by two gene clusters (cpn0146-147 and cpn0284-285) in the c. pneumoniae genome. | 2007 | 17504539 |
| [etology and treatment of community acquired pneumonia in children]. | in children under 5 years, most lower respiratory tract infections are caused by viruses and do not require antibiotics. this is true for almost all episodes of bronchitis and bronchiolitis but also for the majority of pneumonias. atypical pneumonias due to mycoplasma pneumoniae or chlamydia pneumoniae predominate in older children while streptococcus pneumoniae remains by far the most common cause of bacterial pneumonia. diagnosis of pneumonia itself can be difficult and relies on a combination ... | 2007 | 17508663 |
| pcr and serology were effective for identifying chlamydophila pneumoniae in a lower respiratory infection outbreak among military recruits. | during endemic infections, the sensitivity of diagnostic tests and rapid diagnosis of the respiratory tract pathogens is particularly important. utilization of just one diagnostic technique, such as serological tests or polymerase chain reaction (pcr)-based detection methods, during outbreaks of lower respiratory tract infections (lri) can result in some of the patients being missed. in this study we aimed to investigate the etiology of lri in military recruits in izmir, turkey, among whom sever ... | 2007 | 17515640 |
| frequency of chlamydia pneumoniae and mycoplasma pneumoniae infections in children. | chlamydia pneumoniae and mycoplasma pneumoniae are among the most important pathogens of acute respiratory infections in children between the ages of 5 and 15 years. we aimed to investigate seasonal frequency of respiratory infections caused by c. pneumoniae and m. pneumoniae, frequency of coinfection, clinical findings and to determine relationship between clinical findings and laboratory results. | 2007 | 17517817 |
| [combined method of community-acquired pneumonia prevention in military staff]. | efficacy of pneumococcal polysaccharide vaccine "pneumo 23" or its combination with food products prepared from vegetative material for prevention of community-acquired pneumonias has been compared. advantages of combined method of prophylaxis in setting where pneumonia caused by different pathogens have been noted. variability in etiology of community-acquired pneumonia was demonstrated by serological tests of patients' blood. during spring-summer season antibodies to mycoplasma pneumoniae, chl ... | 2007 | 17523490 |
| [the role of endothelial dysfunction and chlamydia pneumoniae infection in patients with ischemic stroke]. | the research purposed to investigate the chlamydia pneumoniae infection in patients with ischemic stroke and to establish the correlation with elevated c. pneumonia antibody titers and endothelial dysfunction. 72 patients with acute ischemic stroke, aged 45 to 75 (45 male and 32 female) have been researched. patients were grouped according to etiology of stroke (based on international classification toast). the blood was taken in 48 hours from stroke onset. elisa method was applied to detect the ... | 2007 | 17525503 |
| systemic cytokine profile in children with community-acquired pneumonia. | characterization of the systemic cytokine response in community-acquired pneumonia (cap) may facilitate our understanding of the host immune response and provide a prognostic as well as diagnostic tool. systemic cytokine characterization of cap has been limited largely to a few integral cytokines in adults. | 2007 | 17534977 |
| is there any relationship between asthma and asthma attack in children and atypical bacterial infections; chlamydia pneumoniae, mycoplasma pneumoniae and helicobacter pylori. | asthma is a chronic inflammatory airway disease characterized by variable airway obstruction and bronchial hyperresponsiveness. there are many factors affecting the development and severity of childhood asthma such as genetic predisposition, atopy, environmental factors, obesity, diet, socioeconomic status, and infectious triggers. in the present study we aimed to investigate the frequency of mycdoplasma pneumoniae, chlamydia pneumoniae, and helicobacter pylori infections in asthmatic children. ... | 2007 | 17535826 |
| higher incidence of persistent chronic infection of chlamydia pneumoniae among coronary artery disease patients in india is a cause of concern. | there is growing evidence that chlamydia pneumoniae may be involved in the pathogenesis of atherosclerosis, as several studies have demonstrated the presence of the organism in atherosclerotic lesions. c. pneumoniae infections, which are especially persistent infections, have been difficult to diagnose either by serological methods or isolation of the organism from the tissue. nucleic acid amplification tests (naats) has emerged as an important method for detecting c. pneumoniae. inspite of high ... | 2007 | 17537253 |
| managing community-acquired pneumonia: a european perspective. | community-acquired pneumonia (cap) is a common disease and a frequent cause of morbidity and mortality worldwide. it puts an enormous burden on medical and economic resources, particularly if hospitalization is required. initial antibacterial therapy for cap is usually empirical, as culture and antibacterial sensitivity test results are rarely available at initial diagnosis. any agent selected for empirical therapy should have good activity against the pathogens commonly associated with cap, a f ... | 2007 | 17548187 |
| community-acquired pneumonia: aetiologic changes in a limited geographic area. an 11-year prospective study. | the aim of this study is to describe the changes in the aetiology of hospitalised patients with community-acquired pneumonia (cap) during an 11-year observational period in a limited geographic area. eight hundred and one (801) adult patients with cap hospitalised were included. the patients were divided into three groups according to the time of presentation. comprehensive microbiological laboratory tests were performed and differences in aetiology were analysed. in 228 patients (31%), a pathog ... | 2007 | 17554569 |
| [transcription factor egr-1 in cardiovascular biology]. | the zinc finger transcription factor egr-l plays an important role in cardiovascular biology. while binding complementary motifs on dna in the target genes, egr-1 either increases or decreases proteosynthesis of many proinflammatory and antiinflammatory mediators. in physiologic circumstances, these mediators support healing and regeneration of damaged tissue, mainly by conducting angioneogenesis. in pathologic circumstances these same mediators take an active part in promoting tissue injury. th ... | 2007 | 17554970 |
| prevalence, genetic conservation and transmissibility of the chlamydia pneumoniae bacteriophage (phicpn1). | the chlamydia pneumoniae bacteriophage was first identified in isolate ar-39. its relevance for chlamydial biology and pathogenicity remains unknown. in this study, a collection of 36 c. pneumoniae isolates was screened and the phage was detected in eight. as the positive isolates differed by several polymorphisms, they presumably belonged to different genetic lineages. it was investigated whether different genotypes of the phage also existed and whether they could be assigned to chlamydial geno ... | 2007 | 17559388 |
| ten years' experience with year-round active surveillance of up to 19 respiratory pathogens in children. | surveillance systems for acute respiratory infections (ari) in children currently are often limited in terms of the panel of pathogens and the age range investigated or are only syndromic and at times only active in the winter season. | 2007 | 17569085 |
| transcription, expression, localization and immunoreactivity of chlamydophila pneumoniae phospholipase d protein. | chlamydophila pneumoniae, a recognized aethiological agent of respiratory infection, is also suspected to play a immuno-pathogenetic role in atherosclerosis by contributing to inflammation and plaque instability. phospholipase d (pld) is an enzyme involved in lipid metabolism, in protein transport and signal transduction, all events which can direct or indirect impact on virulence and inflammatory response. to better understand the role of pld in cell biology and infection by c. pneumoniae, we c ... | 2007 | 17570631 |
| asthmatic persons are prone to the persistence of chlamydia pneumoniae antibodies. | acute chlamydia pneumoniae infection may initiate asthma or worsen asthmatic symptoms. in crowded conditions, such as military service, young men are susceptible to respiratory infections, including c. pneumoniae. we recruited 127 asthmatic and 391 nonasthmatic military conscripts, followed up their respiratory tract infections and the kinetics of serum c. pneumoniae antibodies, and assessed the association between c. pneumoniae and asthma during 6 months of military service in 2 intake groups. ... | 2007 | 17572038 |
| measurement of chlamydia pneumoniae bacterial load in peripheral blood mononuclear cells may be helpful to assess the state of chlamydial infection in patients with carotid atherosclerotic disease. | chlamydia pneumoniae has been repeatedly associated with atherosclerotic cardiovascular diseases. we investigated the pattern of distribution of c. pneumoniae among patients with carotid atherosclerotic disease evaluating chlamydial load in carotid plaque, peripheral blood mononuclear cells (pbmc) and lymph node from same patient. | 2007 | 17575984 |
| chlamydia pneumoniae respiratory infections in taiwan. | to understand the epidemiology of chlamydia pneumoniae acute infections in taiwan, we collected 116 paired and 244 single sera from patients suspected of c. pneumoniae infection and conducted microimmunofluorescence test. eighty-three patients (83/360, 23%) met the diagnostic criteria of current c. pneumoniae infection. the c. pneumoniae infections were significantly higher in men than in women (p< or =0.0001) and were most frequent in the group of 40-49 year-olds, and the people older than 70 y ... | 2007 | 17579263 |
| detection of amyloid beta aggregates in the brain of balb/c mice after chlamydia pneumoniae infection. | neuroinflammation, initiated by cerebral infection, is increasingly postulated as an aetiological factor in neurodegenerative diseases such as alzheimer's disease (ad). we investigated whether chlamydia pneumoniae (cpn) infection results in extracellular aggregation of amyloid beta (abeta) in balb/c mice. at 1 week post intranasal infection (p.i.), cpn dna was detected predominantly in the olfactory bulbs by pcr, whereas brains at 1 and 3 months p.i. were cpn negative. at 1 and 3 months p.i., ex ... | 2007 | 17581756 |
| the effect of infectious burden on the prevalence of atopy and respiratory allergies in iceland, estonia, and sweden. | epidemiologic reports on the effect of microbe exposure on the development of atopy and allergic asthma are inconsistent. | 2007 | 17586034 |
| gene expression profiles of chlamydophila pneumoniae during the developmental cycle and iron depletion-mediated persistence. | the obligate intracellular, gram-negative bacterium chlamydophila pneumoniae (cpn) has impact as a human pathogen. little is known about changes in the cpn transcriptome during its biphasic developmental cycle (the acute infection) and persistence. the latter stage has been linked to chronic diseases. to analyze cpn cwl029 gene expression, we designed a pathogen-specific oligo microarray and optimized the extraction method for pathogen rna. throughout the acute infection, ratio expression profil ... | 2007 | 17590080 |
| evaluation of the diagnostic usefulness of real-time pcr for detection of chlamydophila pneumoniae in acute respiratory infections. | we investigated whether a real-time polymerase chain reaction (pcr) test is a useful diagnostic tool for identifying individuals with acute respiratory chlamydophila pneumoniae infections. nasopharyngeal swab specimens and peripheral blood mononuclear cells (pbmcs) from 100 patients with acute respiratory tract infections and 140 asymptomatic healthy subjects (controls) were analyzed using real-time pcr, culture, and serology for the detection of c. pneumoniae. six patients had serological resul ... | 2007 | 17593507 |
| identification of a ubig-like gene involved in ubiquinone biosynthesis from chlamydophila pneumoniae ar39. | to investigate if one hypothetical protein from chlamydophila pneumoniae ar39 exerts ubig-like function by complementary experiments. | 2007 | 17594460 |
| lack of association between chlamydophila pneumoniae seropositivity and abdominal aortic aneurysm. | chronic chlamydophila pneumoniae infection has been suggested as a possible contributing factor for the development and expansion of abdominal aortic aneurysm (aaa). the relevance of c pneumoniae involved in the processes underlying aneurysmal rupture is unknown. the aim of this study was to examine the relationship between c pneumoniae seropositivity and aaa rupture. in a case-control study, 119 patients with aaa and 36 matched controls were prospectively investigated with c pneumoniae serology ... | 2007 | 17595392 |
| prevalence of chlamydia in patients attending gynecological clinics in south eastern nigeria. | chlamydia infections have been reported to cause silent infections in communities which becomes endemic and could remain unnoticed for a very long time. in most parts of nigeria these organisms are not screened for, and hence relative information about frequencies of the organisms are sparse. | 2007 | 17604521 |
| mycoplasma pneumoniae and chlamydophila pneumoniae in children with community-acquired pneumonia in thailand. | the prevalence of community-acquired pneumonia (cap) caused by atypical pathogens in thai children is unknown. | 2007 | 17609060 |
| cell-specific interleukin-15 and interleukin-15 receptor subunit expression and regulation in pneumococcal pneumonia--comparison to chlamydial lung infection. | interleukin (il)-15 has critical impact on the homeostasis and activation of natural killer cells, natural killer t cells, gammadeltat cells, and cd8(+)t cells, and contributes to antimicrobial defenses particularly at mucosal sites. the respiratory tract comprises a large mucosal surface and harbors significant amounts of lymphocytes, however the expression pattern of il-15 in the lung and its role in local immune responses are largely unknown. we therefore analyzed the differential expression ... | 2007 | 17611121 |
| concentrations in plasma, epithelial lining fluid, alveolar macrophages and bronchial mucosa after a single intravenous dose of 1.6 mg/kg of iclaprim (ar-100) in healthy men. | a validated microbiological assay was used to measure concentrations of iclaprim (ar-100) in plasma, bronchial mucosa (bm), alveolar macrophages (am) and epithelial lining fluid (elf) after a single 1.6 mg/kg intravenous 60 min iv infusion of iclaprim. | 2007 | 17623694 |
| community-acquired pneumonia by chlamydophila pneumoniae: a clinical and incidence study in brazil. | as there was not any data on chlamydia pneumoniae (twar) infections in brazil so far, a prospective cohort study of adult patients hospitalized due to cap was carried out for one year in a brazilian university general hospital to detect the incidence of cap by chlamydophila pneumoniae (twar) for one year. during a whole year 645 consecutive patients hospitalized due to an initial presumptive diagnosis of respiratory diseases by icd-10 (j00-j99), excluding upper respiratory diseases, were screene ... | 2007 | 17625732 |
| q fever community-acquired pneumonia in a patient with crohn's disease on immunosuppressive therapy. | community-acquired pneumonia (cap) may be caused by typical or atypical pathogens. the three most common zoonotic atypical pathogens are chlamydophila psittaci (psittacosis), francisella tularensis (tularemia), and coxiella burnetii (q fever). atypical caps are suggested by a distinctive pattern of extrapulmonary organ involvement. zoonotic cap may be differentiated from nonzoonotic cap (chlamydia pneumoniae, mycoplasma pneumoniae, legionnaire's disease) by a recent zoonotic vector contact histo ... | 2007 | 17628200 |
| differences in the etiology of community-acquired pneumonia according to site of care: a population-based study. | a few population-based studies assessing the etiology of community-acquired pneumonia in both hospitalized and ambulatory patients, with special emphasis on the etiologic role of viral infections, have been reported. the purpose of this study was to assess microbiological differences according to initial site of care in patients with community-acquired pneumonia. | 2007 | 17629472 |
| characterization of in vitro chlamydial cultures in low-oxygen atmospheres. | to mimic in vivo conditions during chlamydial infections, chlamydia trachomatis serovar d and chlamydia pneumoniae cwl029 were cultured in low-oxygen atmospheres containing 4% o(2), with parallel controls cultured in atmospheric air. both were enriched with 5% co(2). the results showed a dramatic increase in the growth of c. pneumoniae but not of c. trachomatis. | 2007 | 17631631 |
| role of irak4 and irf3 in the control of intracellular infection with chlamydia pneumoniae. | tlr signal transduction involves a myd88-mediated pathway, which leads to recruitment of the il-1 receptor (il-1r)-associated kinase 4 (irak4) and toll/il-1r translation initiation region domain-containing adaptor-inducing ifn-beta-mediated pathway, resulting in the activation of ifn regulatory factor (irf)3. both pathways can lead to expression of ifn-beta. tlr-dependent and -independent signals converge in the tnf receptor-associated factor 6 (traf6) adaptor, which mediates the activation of n ... | 2007 | 17360955 |
| the investigation of chlamydophila pneumoniae in patients with multiple sclerosis. | totally 32 cerebrospinal fluid samples from multiple sclerosis (ms) patients were collected. dna was extracted by high pure pcr template preparation kit. two genomic segments, outer membrane protein genes ompa and omp9, were targeted for the detection of c. pneumoniae dna in the samples by pcr tests. to detect ompa, a nested-pcr assay was designed, whereas for omp9, a pcr-enyzme immunoassay (pcr-eia) depending on streptavidin-biotin capture and dig detection of the pcr products was performed. c. ... | 2007 | 17365124 |
| a community outbreak of legionnaires' disease from an industrial cooling tower: assessment of clinical features and diagnostic procedures. | an outbreak of legionnaires' disease (ld) occurred in lidköping, sweden, in august 2004. a cooling tower was identified as the probable source of infection. during the outbreak period an unexpected 3-6-fold increase in pneumonia patients was noted at the local hospital. during 7 weeks ld was diagnosed in 15 patients by urinary antigen and/or sputum culture. additionally, 15 ld patients were diagnosed later by serology. patients with ld were generally younger, more healthy, and more often smokers ... | 2007 | 17366051 |
| effect of pravastatin treatment on chlamydia pneumoniae infection, inflammation and serum lipids in nih/s mice. | 2007 | 17369028 | |
| myd88-dependent changes in the pulmonary transcriptome after infection with chlamydia pneumoniae. | chlamydia pneumoniae, an intracellular bacterium, causes pneumonia in humans and mice. toll-like receptors and the key adaptor molecule myeloid differentiation factor-88 (myd88) play a critical role in inducing immunity against this microorganism and are crucial for survival. to explore the influence of myd88 on induction of immune responses in vivo on a genome-wide level, wildtype (wt) or myd88(-/-) mice were infected with c. pneumoniae on anesthesia, and the pulmonary transcriptome was analyze ... | 2007 | 17374847 |
| identification of human metapneumovirus and chlamydophila pneumoniae in children with asthma and wheeze in singapore. | the aim of our study was to determine if human metapneumovirus (hmpv) and chlamydophila pneumoniae (cp) could be detected in singaporean asthmatic children and wheezing infants during an acute asthma attack. | 2007 | 17384874 |
| the role of chlamydia pneumoniae in the etiology of acne rosacea: response to the use of oral azithromycin. | acne rosacea is a chronic skin disorder that requires long-term therapy. oral azithromycin has been used successfully to treat acne vulgaris. an observation that suggested an infectious agent may play an active role in the etiology of this disorder. ten adults (not previously reported) with acne rosacea were selected to be treated with oral azithromycin. nine of the 10 subjects received 250 mg 3 times weekly for periods ranging from 5 to 19 weeks, at which time follow-up examinations were perfor ... | 2007 | 17388221 |
| chlamydophila pneumoniae infection status is dependent on the subtypes of asthma and allergy. | this study was undertaken to investigate the association of chlamydophila pneumoniae infection (cpi) with asthma and allergy. one hundred forty-one patients with asthma aged 3-21 years, 125 healthy controls aged 3-21 years, and 62 allergic but nonasthmatic patients aged 4-20 years participated in this study. c. pneumoniae-specific antibodies were measured by elisa. there were no significant differences in the percentage of patients positive for c. pneumoniae-specific antibodies between the three ... | 2007 | 17390759 |
| correlation between atherosclerosis and periodontal putative pathogenic bacterial infections in coronary and internal mammary arteries. | chronic infections, such as periodontitis, have been associated with an increased risk for atherosclerosis and coronary artery disease. the aim of this study was to investigate biopsy samples of coronary and internal mammary arteries for the presence of putative pathogenic bacteria (porphyromonas gingivalis, actinobacillus actinomycetemcomitans, prevotella intermedia, and tannerella forsythensis), chlamydia pneumoniae, and human cytomegalovirus (cmv). | 2007 | 17397315 |
| rnase hii from chlamydia pneumoniae discriminates mismatches incorporation into dna-rn1-dna/dna duplexes. | it was reported that rnase hii from chlamydia pneumoniae (cprnase hii) had rnase h activity on rna/dna duplex. we have analyzed the cleavage specificity of cprnase hii on dna-rn1-dna/dna duplex (rn1, one ribonucleotide). various mismatches were introduced into the dna-rn1-dna/dna duplexes at or around the ribonucleotide. the mismatches of duplexes resulted in slower cleavage rates compared to the matched duplexes. furthermore, a greater reduction in cleavage activity was observed for the mismatc ... | 2007 | 17397801 |
| [value of western blotting in serodiagnosis of chlamydial infections]. | the western blot (wb) method was verified for serological diagnosis of chlamydial infections. material and methods: for testing, sera previously examined by the microimmunofluorescence (mif) test with either ambiguous results or those suggesting persistent infection were used. results: whereas the investigation confirmed adequate sensitivity and specificity of the mif test for diagnosing chlamydophila pneumoniae infection, it was less sensitive in case of chlamydia trachomatis. long-term persist ... | 2007 | 17417751 |
| seroprevalence of chlamydia pneumoniae in asthmatic children from northern india. | serum from children with chronic persistent asthma was subjected to c. pneumoniae igg antibody determination. c. pneumoniae igg serology suggestive of persistent infection was significantly higher in chronic persistent asthma group than in the control group. seropositivity was significantly more in moderate and severe persistent groups than in the control subjects. there was no evidence of acute c. pneumoniae infection (igm serology done in duplicate) in acute exacerbations. | 2007 | 17351305 |
| the role of antibiotics in asthma. | there is increasing evidence that atypical respiratory pathogens such as chlamydophila pneumoniae and mycoplasma pneumoniae may contribute to the pathogenesis of both stable asthma and asthma exacerbations. it is postulated that these organisms may contribute to inflammation in the airways possibly by activating inflammatory mechanisms in the respiratory tract. the macrolide class of antibiotics may have a part to play in the management of asthma by exerting anti-inflammatory effects on the chro ... | 2007 | 17353114 |
| host cell responses to chlamydia pneumoniae in gamma interferon-induced persistence overlap those of productive infection and are linked to genes involved in apoptosis, cell cycle, and metabolism. | the respiratory pathogen chlamydia (chlamydophila) pneumoniae is associated with chronic diseases, including atherosclerosis and giant-cell arteritis, which are accompanied by the occurrence of these obligate intracellular bacteria in blood vessels. there, c. pneumoniae seems to be present in a persistent state. persistence is characterized by modified bacterial metabolism and morphology, as well as a reversible arrest of chlamydial development. in cell culture, this persistent state can be indu ... | 2007 | 17353287 |
| etiology of community-acquired pneumonia in hospitalized patients in chile: the increasing prevalence of respiratory viruses among classic pathogens. | background and study objectives: the range and relative impact of microbial pathogens, particularly viral pathogens, as a cause of community-acquired pneumonia (cap) in hospitalized adults has not received much attention. the aim of this study was to determine the microbial etiology of cap in adults and to identify the risk factors for various specific pathogens. | 2007 | 17356093 |
| inflammation as a risk factor for carotid intimal-medial thickening, a measure of subclinical atherosclerosis in haemodialysis patients: the role of chlamydia and cytomegalovirus infection. | atherosclerotic vascular disease is the most frequent complication seen in haemodialysis (hd) patients. evidence suggests that inflammation may play a role in the pathogenesis and progression of atherosclerosis. our aim was to evaluate the causative role of inflammation in atherosclerosis among hd patients. | 2007 | 17295657 |
| infection, inflammation and age-related macular degeneration. | 2007 | 17300563 | |
| chlamydia pneumoniae and age-related macular degeneration: a role in pathogenesis or merely a chance association? | the role of inflammation in the aetiology of age-related macular degeneration (amd) has become very topical as the discovery that genetic variation in complement pathway genes influences the risk of developing amd. complement factor h gene, an inhibitor of the alternative complement activation pathway along with other complement pathway genes factor f (bf) and c2 show significant contribution to the risk of amd. the alternative complement pathway is activated by a trigger, which is often microbi ... | 2007 | 17300581 |
| inflammatory responses following chlamydia pneumoniae infection of glial cells. | recently, infections have been implicated in the pathogenesis of alzheimer's disease. apart from the direct effects of pathogens, it can be hypothesized that inflammatory mechanisms, such as the production of pro-inflammatory mediators by resident glia, may result in neurotoxicity. here, we examined the inflammatory responses in murine microglial cell (mmc) and murine astrocyte cell (mac) lines following infection with chlamydia pneumoniae (cpn), a pathogen that has recently been associated with ... | 2007 | 17313571 |
| molecular characterization of chlamydophila pneumoniae isolates from western barred bandicoots. | chlamydophila pneumoniae is an obligate intracellular respiratory pathogen that has been associated with pneumonia and chronic bronchitis, atherosclerosis, asthma and other chronic diseases in humans. however, c. pneumoniae is not restricted to humans, as originally thought, and can cause infections in several animal hosts. c. pneumoniae was isolated in cell culture from nine western barred bandicoots (perameles bougainville) from australia. the sequences of five genomic regions were determined, ... | 2007 | 17314374 |
| chlamydiae in free-ranging and captive frogs in switzerland. | a total of 210 frog samples originating either from a mass mortality (1991/1992) or from routine postmortem investigations of the years 1990 to 2004 were examined retrospectively for a possible involvement of chlamydiae. for a prevalence study of chlamydia in a selected swiss amphibian population, 403 samples from free-ranging rana temporaria were examined. histopathology, immunohistochemistry using a monoclonal antibody against chlamydial lipopolysaccharide, and a 16s rrna polymerase chain reac ... | 2007 | 17317791 |
| evaluation of csf-chlamydia pneumoniae, csf-tau, and csf-abeta42 in alzheimer's disease and vascular dementia. | the potential role of microbiological factors such as chlamydia pneumoniae (chp) in the pathogenesis of neurodegenerative disorders, including alzheimer's disease (ad) and vascular dementia (vd), has been suggested, but the correctness of this hypothesis still needs to be tested. in this study the appearance of chp in the cerebrospinal fluid (csf) of 57 ad and 21 vd patients and in 47 controls (cg) as well as the influence of chp on the levels of tau protein and abeta42 were investigated. the fr ... | 2007 | 17318713 |
| characterization of the hypothetical protein cpn1027, a newly identified inclusion membrane protein unique to chlamydia pneumoniae. | the hypothetical protein cpn1027 was detected in the inclusion membrane of chlamydia pneumoniae-infected cells with antibodies raised with cpn1027 fusion proteins in an indirect immunofluorescence assay. the inclusion membrane staining by the anti-cpn1027 antibodies co-localized with the staining of an antibody recognizing a known inclusion membrane protein designated inca and these membrane stainings were blocked by the corresponding but not irrelevant fusion proteins. although cpn1027 was not ... | 2007 | 17322198 |
| biochemical characterization and functional complementation of ribonuclease hii and ribonuclease hiii from chlamydophila pneumoniae ar39. | chlamydophila pneumoniae ar39 contains two different orfs (cp0654 and cp0782) encoding ribonuclease h (rnase h) homologues, cpn-rnase hii and cpn-rnase hiii. sequence alignments show that the two homologues both contain the conserved motifs of type 2 rnase h, and cpn-rnase hii has the conserved active-site motif (dedd) of rnase hii. cpn-rnase hiii also contains a unique active-site motif (dede), common to other rnase hiiis. complementation assays indicated that cpn-rnase hii can complement both ... | 2007 | 17322199 |
| risk of concurrent bacterial infection in preterm infants hospitalized due to respiratory syncytial virus infection. | to evaluate the risk of concurrent bacterial infection in preterm infants hospitalized due to respiratory syncytial virus (rsv) disease. | 2007 | 17326757 |
| concurrent increased high sensitivity c-reactive protein and chronic infections are associated with coronary artery disease: a population-based study. | an elevated serum level of c-reactive protein (crp) is an independent predictor of coronary artery disease (cad). chronic infections have also been implicated in the pathogenesis of cad. | 2007 | 17337814 |
| role of viruses and atypical bacteria in asthma exacerbations among children in oporto (portugal). | upper respiratory tract infections are known to be a significant precipitant of acute asthma exacerbations. the aim of this study was to evaluate seasonal trends and the role of these pathogens in asthma exacerbations in school-aged children from oporto (portugal). | 2007 | 17338895 |
| distinct nkt cell subsets are induced by different chlamydia species leading to differential adaptive immunity and host resistance to the infections. | we investigated the role of nkt cells in immunity to chlamydia pneumoniae and chlamydia muridarum infections using a combination of knockout mice and specific cellular activation approaches. the nkt-deficient mice showed exacerbated susceptibility to c. pneumoniae infection, but more resistance to c. muridarum infection. activation of nkt reduced c. pneumoniae in vivo growth, but enhanced c. muridarum infection. cellular analysis of invariant nkt cells revealed distinct cytokine patterns followi ... | 2007 | 17202368 |
| persistent chlamydia pneumoniae infection of cardiomyocytes is correlated with fatal myocardial infarction. | acute myocardial infarction (ami) associated with unfavorable prognosis is likely to be the consequence of a diffuse active chronic inflammatory process that destabilizes the whole coronary tree and myocardium, suggesting a possible common causal agent underlying both conditions. the main objective of this study was to investigate whether chlamydia pneumoniae (cp) infection occurred beyond the coronary plaques, namely in the myocardium of individuals who died of ami. the presence of cp cell wall ... | 2007 | 17200180 |
| anti-p. gingivalis response correlates with atherosclerosis. | significant associations between atherosclerosis and both porphyromonas gingivalis, a major periodontopathogen, and the respiratory pathogen, chlamydia pneumoniae, have been shown. many individuals with evidence of atherosclerosis demonstrate seropositivity to these pathogens. the aim of the present study was to examine the atherogenic effect of repeated immunizations with either or both of these agents, and to determine if molecular mimicry of bacterial heat-shock protein (hsp), termed groel, a ... | 2007 | 17189460 |
| up-regulation of host cell genes during interferon-gamma-induced persistent chlamydia pneumoniae infection in hl cells. | as a step toward understanding the role played by host gene expression in the development and pathogenesis of persistent chlamydia pneumoniae infection, modulation of the host-cell transcriptional response during interferon (ifn)- gamma -induced persistent c. pneumoniae infection of hl cells was examined by a cdna array and then selectively by a real-time quantitative reverse transcription-polymerase chain reaction. we identified 9 host cell genes whose transcription was consistently altered dur ... | 2007 | 17191166 |
| hypothetical protein cpn0308 is localized in the chlamydia pneumoniae inclusion membrane. | the hypothetical protein encoded by chlamydia pneumoniae open reading frame cpn0308 was detected in inclusion membranes of c. pneumoniae-infected cells using antibodies raised with cpn0308 fusion proteins. the anti-cpn0308 antibodies did not cross-react with inca, a known c. pneumoniae inclusion membrane protein, although the anti-cpn0308 antibody staining overlapped with the anti-inca antibody labeling. the labeling of the inclusion membrane by the anti-cpn0308 antibody was specifically blocked ... | 2007 | 17101661 |
| circulating chlamydia pneumoniae dna and advanced coronary artery disease. | chlamydia pneumoniae (c. pneumoniae) has been linked to atherosclerosis. detection of this pathogen in peripheral blood cells may be valuable in the diagnosis of disease state. this study aimed to evaluate the prevalence of circulating c. pneumoniae dna and its relationship with severity and extent of coronary artery disease (cad). | 2007 | 17023075 |
| intranasal administration of chlamydial outer protein n (copn) induces protection against pulmonary chlamydia pneumoniae infection in a mouse model. | chlamydia pneumoniae is an intracellular pathogen that grows inside a vacuole, referred to as an inclusion. c. pneumoniae possess a type iii secretion system (ttss), which allows them to secrete effector molecules into the inclusion membrane and to the host cell cytosol. proteins such as chlamydial outer protein n (copn) that associate with the inclusion membrane are potential targets for the host's mhc-dependent antigen presentation, thereby representing ideal antigen candidates for t cell-base ... | 2007 | 16949182 |
| co-infection with two chlamydophila species in a case of fulminant myocarditis. | the aim of this study is to describe a case of fulminant myocarditis caused by co-infection with chlamydophila pneumoniae and chlamydophila psittaci in order to facilitate diagnosis and clinical management of patients suffering from this rare but life-threatening condition. | 2007 | 17204998 |
| clinical differentiation of atypical pneumonia using japanese guidelines. | atypical pneumonia occupies an important position in community-acquired pneumonia. the aim of this study was to examine whether making a diagnosis of atypical pneumonia is possible based upon the japanese respiratory society guidelines. | 2007 | 17207034 |
| purification and characterization of a 4-hydroxybenzoate decarboxylase from chlamydophila pneumoniae ar39. | chlamydophila pneumoniae ar39 is an obligate intracellular pathogen that causes human acute and chronic respiratory tract diseases. one protein from c. pneumoniae ar39 was assigned as 4-hydroxybenzoate decarboxylase (hbdc). assays done with the purified oxygen-sensitive protein showed that the optimum ph and temperature were 7.5 and 30 degrees c, respectively. the km and vmax obtained for 4-hydroxybenzoate were approximately 0.21 mm and 11.9 nm min(-1) mg(-1), respectively. during the period of ... | 2007 | 17211544 |