Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| propionibacterium acnes brain abscess appearing 10 years after neurosurgery. | to describe a case of propionibacterium acnes infection arising 10 years after neurosurgery and to review the literature regarding similar cases and their treatment. | 2009 | 19506144 |
| histone h4 is a major component of the antimicrobial action of human sebocytes. | antimicrobial peptides, such as cathelicidin and beta defensins, directly kill microbes and have been detected in human sebaceous glands and cell lines. despite the presence of several such peptides, the apparent abundance of these is insufficient for direct killing of most skin pathogens. in this study, we sought to determine which molecules provide the majority of antimicrobial peptide activity in human sebocytes. acid-soluble protein extracts of seb-1 sebocytes were separated by reverse-phase ... | 2009 | 19536143 |
| comparison of 2 clindamycin 1%-benzoyl peroxide 5% topical gels used once daily in the management of acne vulgaris. | combination therapy for the topical treatment of acne vulgaris using benzoyl peroxide (bpo) and an antibiotic is more efficacious and better tolerated than treatment with either component alone. moreover, the addition of bpo to antibiotic therapy is recommended as a means of preventing the development of propionibacterium acnes antibiotic resistance. however, bpo is an irritant, and the dryness and irritation experienced by some patients using topical therapy containing bpo can negatively impact ... | 2009 | 19537284 |
| new developments in our understanding of acne pathogenesis and treatment. | interest in sebaceous gland physiology and its diseases is rapidly increasing. we provide a summarized update of the current knowledge of the pathobiology of acne vulgaris and new treatment concepts that have emerged in the last 3 years (2005-2008). we have tried to answer questions arising from the exploration of sebaceous gland biology, hormonal factors, hyperkeratinization, role of bacteria, sebum, nutrition, cytokines and toll-like receptors (tlrs). sebaceous glands play an important role as ... | 2009 | 19555434 |
| chloracne in seven organic chemists exposed to novel polycyclic halogenated chemical compounds (triazoloquinoxalines). | chloracne is an acneiform eruption caused though poisoning by aromatic compounds (usually halogenated) showing a specific molecular configuration. we describe an outbreak of chloracne among seven discovery chemists who synthesized novel polycyclic halogenated chemical compounds which were classified as triazoloquinoxalines, not known to be chloracnegenic. the diagnosis of chloracne, made clinically, elicited a thorough risk assessment and monitoring programme by the occupational health departmen ... | 2009 | 19558551 |
| antimicrobial activity of fullerenes and their hydroxylated derivatives. | the antimicrobial activities of fullerene c60 and its derivatives against 6 kinds of bacteria and 2 kinds of fungi were evaluated. the tested samples were water-soluble fullerenes (polyvinylpyrrolidone (pvp)/c60, gamma-cyclodextrin (gamma-cd)/c60, and nano-c60) and 3 types of fullerenols (c60(oh)12, c60(oh)36.8h2o, and c60(oh)44.8h2o). their activities were compared with those of (+)-catechin and hinokitiol from the viewpoint of future application to cosmetics. although pristine c60 demonstrated ... | 2009 | 19579658 |
| pathogenesis of acne vulgaris: recent advances. | acne vulgaris is the most common disorder seen in ambulatory dermatology practice. acne causes significant morbidity and the direct costs associated with it exceed $2.2 billion per year in the united states (u.s.). the pathogenesis is multifactorial, and our understanding of the mechanisms involved in the development of acne lesions has improved with time. follicular hyperkeratinization, sebum production, presence of propionibacterium acnes (p. acnes), inflammatory mediators, and androgens have ... | 2009 | 19588637 |
| comparative efficacy and safety results of two topical combination acne regimens. | combination therapy has become the standard for the management of acne, particularly for moderate-to-severe cases. among these combinations, those regimens containing benzoyl peroxide (bpo), clindamycin and a retinoid have been used frequently as they address most aspects of acne pathogenesis. this study compares the efficacy and safety of two common topical treatment regimens in the treatment of a moderate to severe facial acne vulgaris: fixed-combination gel containing bpo 5% and clindamycin 1 ... | 2009 | 19588638 |
| advancement in benzoyl peroxide-based acne treatment: methods to increase both efficacy and tolerability. | antibiotic resistance of propionibacterium acnes (p. acnes) is a growing phenomenon in the wake of widespread use of topical and systemic antibiotics for acne vulgaris. benzoyl peroxide has a proven track record of safety and efficacy, and can decrease reliance on antibiotics in the treatment of acne. | 2009 | 19588642 |
| infectious pericarditis: an experience spanning a decade. | although recent literature suggests a changing spectrum for infectious pericarditis (ip), this view has not been proven. in this report, we aim to review the features of ip in cases from a large tertiary centre. | 2009 | 19593938 |
| resolution of inflammation-related apoptotic processes by the synthetic tellurium compound, as101 following liver injury. | fulminant hepatic failure is a dangerous condition, which occurs when large parts of the liver become damaged beyond repair, and the liver is no longer able to function. this syndrome is induced by inflammatory processes, resulting in acute liver failure. recently, the organotellurium compound, trichloro(dioxoethylene-o,o(')) tellurate (as101), has been found by our group to be able to directly inhibit caspases, due to its te(iv)-thiol chemistry. the aim of this study was to examine the potentia ... | 2009 | 19595469 |
| the facial red fluorescence of ultraviolet photography: is this color due to propionibacterium acnes or the unknown content of secreted sebum? | red fluorescence of the face induced by ultraviolet light is thought to be due to propionibacterium acnes. however, recently there are reports correlating this red fluorescence with the amount of facial sebum secretion. this study was performed to investigate the relationship between the areas of facial red fluorescence with culture results of p. acnes and the amount of sebum secretion. | 2009 | 19622132 |
| heat-killed propionibacterium acnes is capable of inducing inflammatory responses in skin. | the etiology of acne is a complex process, and acne is one of the most common skin disorders affecting millions of people. the pathogenesis of acne is closely associated with the bacterium, propionibacterium acnes which was previously known as corynebacterium parvum. both viable and non-viable p. acnes/c. parvum have been shown to induce an immunostimulatory effect in vivo, suggesting that even dead bacteria continue to activate an inflammatory response. acne treatments with lasers or devices, i ... | 2009 | 19624731 |
| production of superoxide anions by keratinocytes initiates p. acnes-induced inflammation of the skin. | acne vulgaris is a chronic inflammatory disorder of the sebaceous follicles. propionibacterium acnes (p. acnes), a gram-positive anareobic bacterium, plays a critical role in the development of these inflammatory lesions. this study aimed at determining whether reactive oxygen species (ros) are produced by keratinocytes upon p. acnes infection, dissecting the mechanism of this production, and investigating how this phenomenon integrates in the general inflammatory response induced by p. acnes. i ... | 2009 | 19629174 |
| relapse of acne following isotretinoin treatment: a retrospective study of 405 patients. | 2009 | 19213224 | |
| antimicrobial activity of enterocins from enterococcus faecalis sl-5 against propionibacterium acnes, the causative agent in acne vulgaris, and its therapeutic effect. | a lactic acid bacterial strain was isolated from human fecal specimen and identified as enterococcus faecalis sl-5. the isolated strain showed antimicrobial activity against gram-positive pathogens assayed, especially the highest activity against propionibacterium acnes. the antimicrobial substance was purified and verified as a bacteriocin (named esl5) of e. faecalis sl-5 by activity-staining using p. acnes as an indicator. n-terminal sequence of esl5 was determined (mgaiaklvak) and sequence an ... | 2009 | 19229497 |
| chronic prosthetic valve endocarditis due to propionibacterium acnes: an unexpected cause of prosthetic valve dysfunction. | to determine the characteristics of propionibacterium acnes prosthetic valve endocarditis (papve). | 2009 | 19232190 |
| a pivotal role for cd40-mediated il-6 production by dendritic cells during il-17 induction in vivo. | the costimulatory requirements for th17 development remain to be defined. in this study, we show that cd40-deficient animals immunized with the gram-positive bacterium propionibacterium acnes were specifically impaired in their ability to mount an il-17 response, but not that of ifn-gamma. the same cytokine imbalance resulted from in vivo priming with pathogen-pulsed, cd40-deficient dendritic cells (dc). engagement of cd40 on p. acnes-conditioned dc stimulated the release of il-12, il-23, and il ... | 2009 | 19234175 |
| superimposed propionibacterium acnes subdural empyema in a patient with chronic subdural hematoma. | the authors present a case of subdural empyema in a macrocephalic patient. a 23-year-old male was admitted due to headache and fever. one month ago, he had mild head injury by his coworkers. physical examination showed a macrocephaly and laboratory findings suggested purulent meningitis. neuroimaging studies revealed a huge size of epidural space-occupying lesion. under the impression of epidural abscess, operation was performed. eventually, the lesion was located at subdural space and was prove ... | 2009 | 19242574 |
| propionibacterium acnes and sebaceous lipogenesis: a love-hate relationship? | in this issue, iinuma et al. show that propionibacterium acnes (p. acnes)-conditioned medium and formalin-killed p. acnes augment intracellular lipid formation in hamster sebocytes by increasing the de novo synthesis of triacylglycerols. this commentary summarizes the current knowledge of the association of p. acnes with sebaceous lipogenesis, inflammation, and innate immunity, and points out the concurrent evidence that p. acnes-induced lipids may represent a recruitment of allies and/or enemie ... | 2009 | 19809423 |
| detection and hazard assessment of pathogenic microorganisms in medical wastes. | this study was undertaken to investigate the types and concentrations of microbial agents in various medical wastes as well as to characterize their survivals in these wastes at different temperatures for microbial risk assessment. medical wastes collected from 5 major hospitals in south korea were classified and stored at three different temperatures (-20, 6, and 30 degrees c). presence of various microorganisms such as pathogenic viruses and bacteria were investigated by both cultivation and b ... | 2009 | 19827491 |
| characterization of bacterial flora in persistent apical periodontitis lesions. | microorganisms are able to survive and induce persistent infection in periapical tissues. the aim of this study was to investigate the composition of the microflora of persistent apical periodontitis lesions. | 2009 | 19832803 |
| taurine bromamine: a new therapeutic option in inflammatory skin diseases. | acne vulgaris is a multifactorial inflammatory skin disease. one of the pathogenic factors in acne is propionibacterium acnes (p. acnes). traditional treatment of acne lesions involves topical application of antibiotics with anti-bacterial and anti-inflammatory properties. however, a failure of this therapy is widely associated with emergence of resistant bacteria. therefore, a search for alternative topical anti-acne drugs is necessary. taurine bromamine (taubr), the physiological product of hy ... | 2009 | 19847145 |
| oropharyngeal flora changes after tonsillectomy. | we aimed to investigate the effect of tonsillectomy on oropharyngeal flora in children who underwent tonsillectomy for chronic recurrent tonsillitis. | 2009 | 19861199 |
| suture-related complications after cataract surgery: a patient safety issue. | 2009 | 19878852 | |
| acne vaccines targeting propionibacterium acnes. | acne vulgaris is one of the most common skin diseases and can affect a large number of individuals at some point in their lives. though the disease is multi-factorial, the gram-positive, anaerobic bacterium propionibacterium acnes (p. acnes), a member of resident skin microflora, is implicated in acne inflammation and associated with acne lesions. common treatments such as antibiotic or benzoyl peroxide nonspecifically reduce bacteria population on the skin, which may disrupt homeostasis and cau ... | 2009 | 19907403 |
| efficacy of surgical preparation solutions in shoulder surgery. | deep infection following shoulder surgery is a rare but devastating problem. the use of an effective skin-preparation solution may be an important step in preventing infection. the purposes of the present study were to examine the native bacteria around the shoulder and to determine the efficacy of three different surgical skin-preparation solutions on the eradication of bacteria from the shoulder. | 2009 | 19651954 |
| cationic hypericin derivatives as novel agents with photobactericidal activity: synthesis and photodynamic inactivation of propionibacterium acnes. | the present communication describes for the first time the synthesis and preliminary testing of two cationic hypericin derivatives. uncharged hypericin derivatives with omega,omega'-attached c2-linkers leading to a pyridyl or a 4-dimethylaminophenyl residue were prepared and subsequently quaternized by means of iodomethane. photobactericidal activity was assessed using propionibacterium acnes. the quaternary n,n,n-trimethyl-anilinium derivative displayed a pronounced photodynamic inactivation of ... | 2009 | 19659921 |
| clinical and subclinical endometritis in the mare: both threats to fertility. | endometritis, a major cause of mare infertility arising from failure to remove bacteria, spermatozoa and inflammatory exudate post-breeding, is often undiagnosed. defects in genital anatomy, myometrial contractions, lymphatic drainage, mucociliary clearance, cervical function, plus vascular degeneration and inflamm-ageing underlie susceptibility to endometritis. diagnosis is made through detecting uterine fluid, vaginitis, vaginal discharge, short inter-oestrous intervals, inflammatory uterine c ... | 2009 | 19660076 |
| the antimicrobial activity of liposomal lauric acids against propionibacterium acnes. | this study evaluated the antimicrobial activity of lauric acid (la) and its liposomal derivatives against propionibacterium acnes (p. acnes), the bacterium that promotes inflammatory acne. first, the antimicrobial study of three free fatty acids (lauric acid, palmitic acid and oleic acid) demonstrated that la gives the strongest bactericidal activity against p. acnes. however, a setback of using la as a potential treatment for inflammatory acne is its poor water solubility. then the la was incor ... | 2009 | 19665786 |
| single low-dose red light is as efficacious as methyl-aminolevulinate--photodynamic therapy for treatment of acne: clinical assessment and fluorescence monitoring. | this controlled study investigated single low-dose red light photodynamic therapy and methyl-aminolevulinate (mal) for treatment of moderate to severe facial acne in 19 patients. the right cheek was treated with mal (160 mg/g) for 3 h prior to illumination. the left cheek received red light only. both cheeks were illuminated with narrow-band red light (635 nm) at a light dose of 15 j/cm2. the global severity of acne was assessed at baseline and at follow-up, 10 and 20 weeks after treatment. fluo ... | 2009 | 19688149 |
| 5-ala derivative-mediated photoinactivation of propionibacterium acnes. | 2009 | 19709860 | |
| non-purulent low-grade infection as cause of pain following shoulder surgery: preliminary results. | low-grade infection was systematically searched for in all revision shoulder surgeries by harvesting tissue samples. ten consecutive patients were identified with a non-purulent low-grade infection of the shoulder. all of these patients suffered from pain and eight were stiff. preoperative aspiration in eight patients yielded bacterial growth in only one case. serum c-reactive protein levels were normal in seven out of 10 cases. propionibacterium acnes was identified in seven, coagulase-negative ... | 2009 | 19711173 |
| squalene as a target molecule in skin hyperpigmentation caused by singlet oxygen. | based on our previous finding (biochem. biophys. res. commun., 223, 578-582, 1996) of singlet oxygen generation from coproporphyrin excreted on the skin surface from propionibacterium acnes, we hypothesized that singlet oxygen formed in this way under uv exposure would promote peroxidation of skin surface lipids. we found that squalene was oxidized efficiently by singlet oxygen derived from coproporphyrin under uv exposure, and that the rate constant of squalene peroxidation by singlet oxygen wa ... | 2009 | 19721223 |
| postoperative joint infections due to propionibacterium species: a case-control study. | we compared 40 patients with propionibacterium acnes postoperative joint infection to a cohort of uninfected patients. infection manifested a median of 210 days after surgery. most patients with joint prostheses underwent hardware removal. prior joint surgery (odds ratio [or], 28.2) and male sex (or, 7.2) were independent risk factors for infection. | 2009 | 19725786 |
| nicotinamide inhibits propionibacterium acnes-induced il-8 production in keratinocytes through the nf-kappab and mapk pathways. | propionibacterium acnes (p. acnes) has been implicated in the inflammatory phase of acne vulgaris. it has been shown to activate interleukin-8 (il-8) secretion by interacting with toll-like receptor 2 (tlr-2) on the surface of keratinocytes. nicotinamide has been shown to be an effective treatment for skin inflammation in various conditions, including acne vulgaris. | 2009 | 19726162 |
| in vitro activity of chlorhexidine and pentane-1,5-diol and their combination on candida albicans, staphylococcus aureus and propionibacterium acnes. | 2009 | 19734980 | |
| adjuvant effect of lps and killed propionibacterium acnes on the development of experimental gastrointestinal nematode infestation in sheep. | gastrointestinal helminthic infection is an important worldwide sheep disease. the emergence of anthelminthic resistance has led to drives to seek new means of therapeutic control of helminthiasis in sheep. several data demonstrated the adjuvant effect of propionibacterium acnes on resistance to infection. herein, we evaluate the adjuvant effect of the commercial suspension containing lps and p. acnes on experimental helminthiasis. sheep received three doses of lps and p. acnes commercial suspen ... | 2009 | 19751472 |
| antigen-dependent rescue of nose-associated lymphoid tissue (nalt) development independent of ltbetar and cxcr5 signaling. | nose-associated lymphoid tissue (nalt) in the rodent upper respiratory tract develops postnatally and is considered to be independent of several factors known to be involved in the organogenesis of ln and peyer's patches (pp). in this study we demonstrate that at least two different pathways result in nalt development. following nalt anlage formation the intrinsic pathway relies on a signaling cascade including those mediated through the chemokine receptor cxcr5 and the lymphotoxin beta receptor ... | 2009 | 19757439 |
| benzoyl peroxide: a review of its current use in the treatment of acne vulgaris. | owing to the use of topical and systemic antibiotics for acne vulgaris, the incidence of antibiotic-resistant propionibacterium acnes is increasing worldwide. topical benzoyl peroxide (bpo) is an alternative to antibiotics in the treatment of acne vulgaris. | 2009 | 19761357 |
| emerging drugs for acne. | acne vulgaris is a common skin disorder that affects most individuals at some point in their lives. it may result in significant morbidity, including cutaneous scarring and psychological impairment. current treatments include topical retinoids, benzoyl peroxide, topical and systemic antibiotics, and systemic isotretinoin. there are growing concerns of rising antibiotic resistance, significant side effects of isotretinoin therapy, and lack of safe and effective treatment for pregnant females. rec ... | 2009 | 19772370 |
| efficacy of antibiotic therapy for sapho syndrome is lost after its discontinuation: an interventional study. | the acronym sapho was introduced in 1987 to unify the various descriptions of a seronegative arthritis associated with skin manifestations and to show synovitis, acne, pustulosis, hyperostosis, and osteitis with and without sterile multifocal osteomyelitis. the etiology of sapho syndrome is unknown, but an association with infection by semipathogenic bacteria like propionibacterium acnes has been suggested. we conducted an interventional study of sapho patients receiving antibiotics. | 2009 | 19772564 |
| new insights into synovitis, acne, pustulosis, hyperostosis, and osteitis (sapho) syndrome. | in 1987, synovitis, acne, pustulosis, hyperostosis and osteitis (sapho) syndrome was proposed as an umbrella term for a group of diseases with similar musculoskeletal manifestations, in particular hyperostosis of anterior chest wall, synovitis, and multifocal aseptic osteomyelitis, observed in association with dermatologic conditions such as palmoplantar pustulosis, severe acne, and hidradenitis suppurativa. despite recent advances in our understanding of the epidemiologic, pathophysiologic, and ... | 2009 | 19772827 |
| incidence, clinical features, causative organisms, and visual outcomes of delayed-onset pseudophakic endophthalmitis. | to report the incidence, clinical features, causative organisms, and visual outcomes associated with delayed-onset pseudophakic endophthalmitis. | 2009 | 19787601 |
| expression of toll-like receptor 2 on peripheral blood monocytes of patients with inflammatory and noninflammatory acne vulgaris. | the pathogenesis of acne vulgaris is multifactorial and entails the interplay of hormonal, microbial and immunological events. the bacterium propionibacterium acnes is involved in the induction of comedogenesis and maintenance of the inflammatory phase of acne. toll-like receptor 2 (tlr2) expressed on mononuclear inflammatory cells and possibly on keratinocytes and sebocytes is thought to be of vital importance in mediating p. acnes-induced inflammatory response in acne vulgaris. this work aimed ... | 2009 | 20726329 |
| antibacterial effects of minerals from ores indigenous to korea. | we tested the antibacterial properties of a mix of minerals consisting mainly of sericite, talc, and halloysite from korea. the preparation showed clear growth inhibition of the gram-negative bacteria escherichia coli and pseudomonas aeruginosa, and the gram-positive bacteria staphylococcus aureus subsp. aureus, s. epidermidis, and bacillus cereus, as well as the anaerobic bacterium propionibacterium acnes. these results indicate that this preparation, made from ore minerals indigenous to korea, ... | 2009 | 20112878 |
| suture-related corneal infections: should all sutures be routinely removed after phacoemulsification? | 2009 | 19969244 | |
| suture-related corneal infections. | 2009 | 19969245 | |
| anaerobic bacteria as a cause of mycotic aneurysm of the aorta: microbiology and antimicrobial therapy. | this review summarizes the microbiology, and antimicrobial management of mycotic aneurysm of the aorta (maa) due to anaerobic bacteria. anaerobic bacteria are an uncommon but important cause of maa. most cases of anaerobic maa are caused anaerobic gram-negative bacilli (mostly b. fragilis group), clostridium spp. (mostly clostridium septicum, and propionobacterium spp. (mostly p. acnes). clostridial infection is frequently associated with gastrointestinal or hematologic malignancy. a review of a ... | 2009 | 20066146 |
| cutaneous induction of corticotropin releasing hormone by propionibacterium acnes extracts. | the skin commensal bacillus propionibacterium acnes is known to play a major role in the development of acne vulgaris and it is established that this bacteria is involved both in the induction and maintenance of the inflammatory phase of acne. the corticotropin releasing hormone (crh), a neuropeptide originally isolated from the hypothalamus, is also produced by the skin. crh has been reported to play a role in the inflammation, the production of sebum and finally the differentiation of keratino ... | 2009 | 20224691 |
| is there evidence for a role of propionibacterium acnes in prostatic disease? | 2009 | 18407335 | |
| what is the significance of a positive propionibacterium acnes culture around a joint replacement? | the purpose of this study was to show the significance of a positive propionibacterium acnes sample around a joint replacement. records from the microbiology laboratory data over a 3-year period were reviewed to identify patients with prosthetic joints from whom propionibacterium acnes was isolated at least once. the medical records of all those patients were retrieved and the demographic, clinical, microbiological and haematological data were collected and examined. the preoperative values of e ... | 2009 | 18327582 |
| expression, purification, crystallization and preliminary x-ray diffraction analysis of the soluble domain of ppa0092, a putative nitrite reductase from propionibacterium acnes. | the soluble domain (residues 483-913) of ppa0092, a putative copper-containing nitrite reductase from propionibacterium acnes kpa171202, has been overexpressed in escherichia coli. the purified recombinant protein was crystallized using the hanging-drop vapour-diffusion method. x-ray diffraction data were collected and processed to a maximum resolution of 2.4 a. the crystal belonged to space group p2(1)3, with unit-cell parameters a = b = c = 108.63 a. preliminary diffraction data show that one ... | 2009 | 19194001 |
| in vitro evaluation of antibacterial, anticollagenase, and antioxidant activities of hop components (humulus lupulus) addressing acne vulgaris. | seven naturally derived components from hop plant (humulus lupulus l.) extracts were tested for evaluation of biological activities affecting acne vulgaris. five strains, propionibacterium acnes, staphylococcus epidermidis, staphylococcus aureus, kocuria rhizophila and, staphylococcus pyogenes, were selected as the main acne-causing bacteria. hop extracts xanthohumol and the lupulones showed strong inhibitory activities against all of the strains. although hydrogenated derivatives did not show t ... | 2009 | 19201179 |
| the antibacterial activity of clove essential oil against propionibacterium acnes and its mechanism of action. | 2009 | 19153353 | |
| on the mechanism of a polyunsaturated fatty acid double bond isomerase from propionibacterium acnes. | the catalytic mechanism of propionibacterium acnes polyunsaturated fatty acid isomerase (pai) is explored by kinetic, spectroscopic, and thermodynamic studies. the pai-catalyzed double bond isomerization takes place by selective removal of the pro-r hydrogen from c-11 followed by suprafacial transfer of this hydrogen to c-9 as shown by conversion of c-9-deuterated substrate isotopologs. data on the midpoint potential, photoreduction, and cofactor replacement suggest pai to operate via an ionic m ... | 2009 | 19164287 |
| characterization of beta-1,3-galactosyl-n-acetylhexosamine phosphorylase from propionibacterium acnes. | homologs of the beta-1,3-galactosyl-n-acetylhexosamine phosphorylase (galhexnacp) gene (gnpa) were cloned from the genomic dna of propionibacterium acnes jcm6425 and p. acnes jcm6473, showing 99.9% and 97.9% nucleotide sequence identity, respectively, with the ppa0083 gene from the genome-sequenced p. acnes kpa171202. no gnpa gene was detected in the genomic dna of type strain p. acnes atcc25746. the recombinant enzyme from p. acnes jcm6425 (gnpa) showed approximately 70 times higher specific ac ... | 2009 | 19132369 |
| in vitro activity of nadifloxacin against several gram-positive bacteria and analysis of the possible evolution of resistance after 2 years of use in germany. | nadifloxacin has good activity against propionibacterium acnes as well as against both meticillin-susceptible and -resistant staphylococcus aureus (mssa and mrsa, respectively) and staphylococcus epidermidis. the aim of this study was to evaluate the activity of this fluoroquinolone against the abovementioned microorganisms, comparing isolates collected in 2007 in germany, a country where nadifloxacin has been used for the last 2 years, with isolates collected from 2006-2007 in spain where nadif ... | 2009 | 19095414 |
| in vitro anti-adhesive activity of green tea extract against pathogen adhesion. | camellia sinensis polysaccharide has been reported to possess anti-adhesive activity against pathogens. the present study was designed to investigate whether hot water extracts obtained from green tea leaves might inhibit pathogen adhesion to human or mouse cell lines. green tea extract-4 (csi-4) with the maximum yield of 4% (w/v) is composed of a major proportion of carbohydrates containing 40% uronic acids, but lack of catechins. it showed strong inhibitory activities against hemagglutination ... | 2009 | 19107860 |
| the prevalence and pathogenicity of propionibacterium acnes keratitis. | to study the prevalence, pathogenicity, and virulence of propionibacterium acnes keratitis. | 2009 | 19092402 |
| effectiveness of the antibiotic lock therapy for the treatment of port-related enterococci, gram-negative, or gram-positive bacilli bloodstream infections. | the purpose of this study is to evaluate the efficacy of antibiotic lock therapy to treat port-related enterococci, gram-negative, or gram-positive bacilli bloodstream infections. | 2009 | 19026506 |
| characterization of propionibacterium acnes isolates from sarcoid and non-sarcoid tissues with special reference to cell invasiveness, serotype, and trigger factor gene polymorphism. | sarcoidosis is a systemic granulomatous disease of unknown etiology. propionibacterium acnes is the only microorganism so far isolated from sarcoid lesions. to examine whether p. acnes isolates from sarcoid tissues differ from those obtained from non-sarcoid tissues, we studied cell invasiveness, serotype, and polymorphisms of the p. acnes trigger factor protein and the two invasion-associated proteins (named pamce and pap60) in 35 p. acnes isolates from sarcoid lymph nodes and 127 isolates from ... | 2009 | 19049821 |
| no evidence for presence of bacteria in modic type i changes. | recent studies suggest an association between sciatica and propionibacterium acnes. "modic type i changes" in the vertebrae are closely associated with sciatica and lower back pain, and recent studies have questioned the ability of conventional magnetic resonance imaging (mri) to differentiate between degenerative modic type i changes and vertebral abnormalities caused by infection. | 2009 | 19052939 |
| rapid detection and quantification of propionibacteriaceae. | propionibacteriaceae (propioni) are anaerobic bacteria associated with human and animal infections. present-day methods of diagnosis for propioni are unsatisfactory due to a lack of sensitivity of culture, time required for culture results (3 to 14 days) and difficulties in interpreting sybr green real-time pcr results. the goal of this work was to validate a new rapid and sensitive test for the diagnosis of propioni infections (endophthalmitis, corneal ulcers and others). material and methods: ... | 2009 | 18977791 |
| clinical considerations in the treatment of acne vulgaris and other inflammatory skin disorders: a status report. | this article reviews the anti-inflammatory and nonantimicrobial effects of antibiotics in acne and other diseases and examines issues relating to the emergence of decreased bacterial sensitivity to antibiotics and how these issues relate to clinical practice. it includes an overview of the inflammatory activities of some antibiotic agents and their potential for use in various dermatologic and nondermatologic diseases. it demonstrates that p. acnes-resistant organisms may be associated with ther ... | 2009 | 18984363 |
| optimizing use of oral antibiotics in acne vulgaris. | oral antibiotics are commonly used to treat acne vulgaris, primarily in patients presenting with moderate to severe facial or truncal disease severity. these agents are most appropriately used in combination with a topical regimen containing benzoyl peroxide and a topical retinoid. the most common oral antibiotics for treating acne vulgaris are the tetracycline derivatives, although macrolide agents such as erythromycin have also been used extensively. over the past 4 decades, as the sensitivity ... | 2009 | 18984366 |
| lowering lesional surface ph in acne: a new treatment modality for herpifix. | the acid skin surface ph has antimicrobial activities. increased growth of propionibacterium acnes contributes to the pathogenesis of acne. therefore, the ph of inflammatory acne lesions was determined prior to and after lesional acidification employing herpifix (courage + khazaka, cologne, germany), a microphoretic system. the ph was correlated with the number of acne lesions. a total of 30 volunteers with acne vulgaris participated in this crossover study applying either herpifix or a dummy to ... | 2009 | 18618363 |
| glucocorticoids enhance toll-like receptor 2 expression in human keratinocytes stimulated with propionibacterium acnes or proinflammatory cytokines. | toll-like receptors (tlrs) on keratinocytes are important cell surface receptors involved in the innate and acquired immune response to invading microorganisms. in acne vulgaris, tlr2 activation by propionibacterium acnes (p. acnes) may induce skin inflammation via induction of various proinflammatory molecules that stimulate the invasion of inflammatory cells. although corticosteroids themselves exert immunosuppressive or anti-inflammatory effects, it is well known clinically that systemic or t ... | 2009 | 18704103 |
| "sapho syndrome and infections". | the syndrome of synovitis, acne, pustulosis, hyperostosis, osteitis (sapho) encompasses a broad spectrum of cutaneous manifestations associated with osteitic and hyperostotic lesions, which typically may involve the anterior chest wall (acw). the aetiopathogenetic mechanisms as well as the nosographic framing of the disease are still not fully defined although an important role has been suggested for propionibacterium acnes (p. acnes). this germ might be able to stimulate both the innate and the ... | 2009 | 18721907 |
| resolution of pigmented keratic precipitates following treatment of pseudophakic endophthalmitis caused by propionibacterium acnes. | propionibacterium acnes is a well-recognized cause of chronic postoperative endophthalmitis after cataract surgery. the subtle clinical signs of this infection and its initial favorable response to topical steroids may lead to delayed diagnosis and treatment. two patients with culture proven p. acnes endophthalmitis after cataract surgery that presented with prominent pigmented keratic precipitates (kps) and low-grade iritis in the involved eye were managed. both cases had initial treatment with ... | 2010 | 20337310 |
| infected giant ophthalmic artery aneurysm remnant following craniotomy for surgical clip ligation. case report. | postoperative intracranial infections, although found in only a minority of surgical cases, remain a recognized potential complication following elective craniotomy. in the treatment of intracranial aneurysms, specifically, reports of significant postoperative infections are rare. significant postoperative infections are usually observed in association with foreign bodies, such as aneurysm clips, endovascular coils, or materials used for aneurysm wrapping. the authors present a case in which a p ... | 2010 | 20345224 |
| effective and safe combination therapy for severe acne vulgaris: a randomized, vehicle-controlled, double-blind study of adapalene 0.1%-benzoyl peroxide 2.5% fixed-dose combination gel with doxycycline hyclate 100 mg. | there is a paucity of treatment options for severe acne vulgaris aside from oral isotretinoin. this randomized, vehicle-controlled, multicenter, double-blind study evaluated the efficacy and safety of combination therapy using adapalene 0.1%-benzoyl peroxide 2.5% (a/bpo) fixed-dose combination gel with doxycycline hyclate 100 mg in the treatment of severe acne vulgaris. a total of 459 participants were randomized in a 1:1 ratio to receive oral doxycycline hyclate 100 mg once daily and either a/b ... | 2010 | 20349684 |
| inhibitory effects of fortunella japonica var. margarita and citrus sunki essential oils on nitric oxide production and skin pathogens. | a number of essential oils from citrus peels are claimed to have biological activities. citrus peel, called 'jin-pi', is used in traditional medicine for digestion, severe cold, and fever. however, the antibacterial activities against skin pathogens and anti-inflammatory effects of the essential oils of citrus sunki (jingyul) and fortunella japonica var. margarita (gumgyul) have not yet been described. therefore, in this study, the essential oils of the citrus species c. sunki (cse) and f. japon ... | 2010 | 20350876 |
| bacterial colonization and infection of electrophysiological cardiac devices detected with sonication and swab culture. | electrophysiological cardiac devices are increasingly used. the frequency of subclinical infection is unknown. we investigated all explanted devices using sonication, a method for detection of microbial biofilms on foreign bodies. | 2010 | 20368521 |
| transdermal absorption enhancement through rat skin of gallidermin loaded in niosomes. | gallidermin (gdm) loaded in anionic niosomes composed of tween 61/chl/dp (1:1:0.05 molar ratio) gave the highest entrapment efficiency (45.06%). this formulation gave antibacterial activity against propionibacterium acnes and staphylococcus aureus with the mic and mbc of 3.75 and 7.5; 7.5 and 15 microg/microl, respectively. gdm loaded in niosomes was more chemically stable than gdm in aqueous solution of about 1.5 times. gdm loaded and unloaded in niosomes were not found in the receiver solution ... | 2010 | 20381599 |
| heart valve allograft decontamination with antibiotics: impact of the temperature of incubation on efficacy. | heart valve allografts are typically processed at 4°c in north america, including the step of antibiotic decontamination. in our own experience with heart valve banking, we often observe persistent positive cultures following decontamination at wet ice temperature. we hypothesized that warmer temperatures of incubation might increase the efficacy of the decontamination procedure. in a first series of experiments, 12 different bacterial species were grown overnight, frozen in standardized aliquot ... | 2010 | 20390362 |
| propionibacterium acnes infection induces upregulation of inflammatory genes and cytokine secretion in prostate epithelial cells. | the immune stimulating bacterium propionibacterium acnes is a frequent colonizer of benign and malignant prostate tissue. to understand the pathogenesis of the earliest phase of this infection, we examined the p. acnes triggered immune response in cultivated prostate epithelial cells. | 2010 | 20420679 |
| experimental pulmonary granuloma mimicking sarcoidosis induced by propionibacterium acnes in mice. | propionibacterium acnes has been implicated as an etiologic agent of sarcoidosis since the isolation of this bacterium from sarcoid lesions. we experimentally produced a murine pulmonary granuloma model using p. acnes with several features that simulate sarcoidosis. mice were sensitized with heat-killed p. acnes and complete freund's adjuvant and were subsequently challenged with heat-killed p. acnes at 2-week intervals. p. acnes-challenged mice developed epitheloid cell granulomas in the lungs. ... | 2010 | 20424662 |
| quantitative pcr of propionibacterium acnes dna in samples aspirated from sebaceous follicles on the normal skin of subjects with or without acne. | to elucidate whether people with hair follicles containing many propionibacterium acnes cells are prone to acne, we developed a novel method to count the number of p. acnes in hair follicles. we sampled sebaceous material in hair follicles by aspiration at a constant negative pressure from the nose, forehead, and upper arm of 86 patients with acne vulgaris and 209 control subjects with healthy skin, including 84 subjects age-matched to the patients. genome-equivalents of p. acnes in samples were ... | 2010 | 20437767 |
| a biofilm approach to detect bacteria on removed spinal implants. | this is a prospective study comparing the diagnosis of spinal implant infection by conventional peri-implant tissue culture with a technique which uses a combination of vortexing and bath sonication to dislodge bacteria growing as a biofilm on the surface of retrieved spinal implants. | 2010 | 20445479 |
| bacterial resistance in french acne patients. | the percentage of strains of propionibacterium acnes resistant to antibiotics in acne is increasing in many countries, raising the question of the risks associated with bacterial resistance. numerous series of cases have been published on european populations of acne patients, but at the moment we still have very few data regarding france. | 2010 | 20465665 |
| trends in the treatment of acne vulgaris: are measures being taken to avoid antimicrobial resistance? | acne vulgaris has been treated with long-term courses of antibiotics since the 1960s. antibiotic-resistance of propionibacterium acnes (p. acnes) was first documented in the late 1970s, and, over 20 years later, the problem of antibiotic resistance still exists. | 2010 | 20480795 |
| evaluation of the bact/alert 3d system for the implementation of in-house quality control sterility testing at canadian blood services. | background: until recently, canadian blood services (cbs) was performing quality control sterility testing of blood components using three different processes. this study was conducted in order to standardize sterility testing at all cbs centers in a cost-effective manner using the bact/alert 3d system. methods: blood components including fresh frozen plasma, platelet concentrates, and red blood cells were inoculated with eight bacterial species at target concentrations of 1 and 10 cfu/ml. pre- ... | 2010 | 20482299 |
| [systemic antibiotic therapy of acne vulgaris]. | inflammatory, medium to severe acne vulgaris is treated with systemic antibiotics worldwide. the rationale is an effect on propionibacterium acnes as well as the intrinsic anti-inflammatory properties of these antibiotics. although there are no correlations between the number of p. acnes and the severity of the disease, associations between the degree of humoral and cellular immune-responses against p. acnes and the severity of acne have been reported. exact data with respect to daily use of the ... | 2010 | 20482690 |
| isotretinoin: state of the art treatment for acne vulgaris. | summary isotretinoin (13-cis retinoic acid) is the most potent known inhibitor of sebum production. the multiple modes of action for isotretinoin, including suppression of sebaceous gland activity, normalization of the pattern of keratinization within the sebaceous gland follicle, inhibition of inflammation, reduction of growth of propionibacterium acnes in a secondary manner and, as currently shown, normalization of the expression of matrix tissue metalloproteinases and their inhibitors make th ... | 2010 | 20482692 |
| [modern aspects of acne pathogenesis]. | acne is worldwide the most common skin disease. | 2010 | 20482694 |
| [postoperative discitis due to propionibacterium acnes]. | 2010 | 20493657 | |
| selective microbial aerosolization in biogas demonstrated by quantitative pcr. | aerosolization of bacteria, archaea, synergistes, staphylococcus spp. and propionibacterium acnes was investigated in situ with quantitative real-time pcr of dna isolated from sludge and biogases of anaerobic digesters. the data revealed that in biogas, staphylococcus spp. and p. acnes were, respectively, aerosolized 30 and 220 times more and archaea and synergistes, respectively, 8 and 20 times less aerosolized than bacteria. this is the first demonstration of selective microbial aerosolization ... | 2010 | 20494574 |
| the human nasal microbiota and staphylococcus aureus carriage. | colonization of humans with staphylococcus aureus is a critical prerequisite of subsequent clinical infection of the skin, blood, lung, heart and other deep tissues. s. aureus persistently or intermittently colonizes the nares of approximately 50% of healthy adults, whereas approximately 50% of the general population is rarely or never colonized by this pathogen. because microbial consortia within the nasal cavity may be an important determinant of s. aureus colonization we determined the compos ... | 2010 | 20498722 |
| anti-acne-inducing bacterial activity of mangosteen fruit rind extracts. | the aims of this study were to determine the most effective solvent extract of mangosteen, anti-acne- inducing bacterial activity and the amount of alpha-mangostin, a major active component in each mangosteen fruit rind extract, using high-performance liquid chromatography (hplc). | 2010 | 20516704 |
| systemic toxicity of non-cell corynebacterium parvum (cp) in monkeys. | non-cell corynebacterium parvum product (ncpp) is a new preparation of corynebacterium parvum (cp), an immunomodulator that displays anticancer activities. it is prepared by nanotechnology and is intended to minimize the side effects of cp. the aim of the present study was to evaluate the immunogenicity and systemic toxicity of ncpp compared with cp in animals. | 2010 | 20519835 |
| syntheses and antibacterial activities of diterpene catechol derivatives with abietane, totarane and podocarpane skeletons against methicillin-resistant staphylococcus aureus and propionibacterium acnes. | natural catechol, quinone and quinone methide diterpenes with abietane (15-deoxyfuerstione, taxodione) and totarane (dispermone, 12,13-dihydroxy-8,11,13-totaratriene-6-one), and podocarpane (nimbidiol, deoxynimbidiol) skeletons were synthesized using ortho-oxidation of phenol with meta-chlorobenzoyl peroxide. minimum inhibitory activities of these diterpenes and previously synthesized natural diterpenes were measured against methicillin-resistant staphylococcus aureus (mrsa) and propionibacteriu ... | 2010 | 20522992 |
| detection of a new erm(x)-mediated antibiotic resistance in egyptian cutaneous propionibacteria. | a total of 107 antibiotic-resistant propionibacteria were isolated from the face of 102 egyptian acne patients, dermatology staff and controls. erythromycin-clindamycin-resistant propionibacteria were chosen to detect erm(x) gene and it was detected in 29 of 107 (27%) strains. however, just 7 strains had is1249i, 3 of them had also tn5432. the erm(x) gene which is not carried on tn5432 confers inducible resistance to telithromycin by erythromycin or clindamycin. the dna sequences of the pcr ampl ... | 2010 | 20541615 |
| the role of propionibacterium acnes in acne pathogenesis: facts and controversies. | we have come a long way since 1896, when it was first suggested that propionibacterium acnes, found in acne lesions, was the cause of acne. although several lines of evidence suggest the direct role of p acnes in acne, the mechanism by which p acnes contributes to the pathogenesis of acne is debated. the importance of p acnes in the induction and maintenance of the inflammatory phase of acne has been established. emerging data that inflammatory events occur in the very earliest stages of acne de ... | 2010 | 20082942 |
| the role of facial sebum secretion in acne pathogenesis: facts and controversies. | increased sebum secretion has been known as one of the major pathogenic factors in the development of acne; however, objective sebum measurement methods have been developed only recently. we have limited information about the association of sebum secretion, and the development of acne. there continues to be controversy about the role of sebum in the development of acne. this contribution will discuss sebum measurement techniques and the results of recent studies on the relationship of sebum, fac ... | 2010 | 20082943 |
| bacterial contamination of the vitreous cavity associated with transconjunctival 25-gauge microincision vitrectomy surgery. | to evaluate differences in the bacterial contamination rates of the vitreous cavity between patients undergoing transconjunctival 25-gauge microincision vitrectomy surgery (mivs) and conventional 20-gauge pars plana vitrectomy (ppv). | 2010 | 20097429 |
| identification of bacteria enduring endodontic treatment procedures by a combined reverse transcriptase-polymerase chain reaction and reverse-capture checkerboard approach. | this study identified the bacterial taxa enduring endodontic treatment procedures by using a combined 16s ribosomal rna-based reverse-transcriptase polymerase chain reaction (rt-pcr) and reverse-capture checkerboard hybridization approach. | 2010 | 20003934 |
| sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-defensin-2 expression. | various sebum free fatty acids (ffas) have shown antibacterial activity against a broad range of gram-positive bacteria, resulting in the suggestion that they are accountable, at least partially, for the direct antimicrobial activity of the skin surface. in this study, we examined the effects of sebum ffas on the antimicrobial peptide (amp)-mediated innate immune defense of human sebocytes. incubation of lauric acid, palmitic acid, or oleic acid (oa) with human sebocytes dramatically enhanced th ... | 2010 | 20032992 |
| in vitro activities of azole antifungal agents against propionibacterium acnes isolated from patients with acne vulgaris. | the gram-positive bacterium propionibacterium acnes is the causative agent of acne vulgaris. antibiotics such as tetracycline and macrolide derivatives are used to treat this skin disease; however, the isolation frequency of antibiotic-resistant p. acnes has been increasing. the anti-p. acnes activity of imidazole antifungal agents was reported more than 20 years ago, and since then, new azole antifungal agents have been marketed. thus, this study determined the in vitro activities of azole anti ... | 2010 | 20045949 |
| syntheses of carnosic acid and carnosol, anti-oxidants in rosemary, from pisiferic acid, the major constituent of sawara. | carnosic acid (2), a major anti-oxidant in rosemary (rosmarinus officinalis), was synthesized from pisiferic acid (1), the major constituent of sawara (chamaecyparis pisifera), via ortho-oxidation of the phenol using meta-chlorobenzoyl peroxide (mcbpo), chloroacetyl meta-chlorobenzoyl peroxide (camcbpo) or 2-iodoxybenzoic acid (ibx). carnosol (3), another anti-oxidant in rosemary, was synthesized from carnosic acid by oxidation with silver oxide. potent antibacterial activities against propionib ... | 2010 | 20045961 |