Publications

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dominant goniodysgenesis with late congenital glaucoma. a re-examination of berg's pedigree. 20154624765
[2 cases of rieger's syndrome]. 20154690013
constancy of relative body weight in children. 20154703069
constancy of relative body weight in children. 20154703069
[medicine--not philosophy, physician's contribution to public discussions]. 20154635047
micro-magnetic stirrer. 20154593884
[case of multiple molluscum contagiosum of palpebral and facial skin]. 20154690011
[endoscopy in gastroenterology]. 20154792331
[endoscopy in gastroenterology]. 20154792331
relationship between rna metabolism and cell cycle in acute leukaemia. 20154626603
speed and resolution of systems for camera units. 20154829326
[study of the "epidemic" appearance of upper digestive hemorrhages and correlations with some meteorological and geophysical phenomena]. 20154544785
[effect of sanatorial treatment at szczawno-zdrój on the incidence of recurrences of nephrolithiasis following surgical removal of concrements from the urinary tract]. 20154643108
the wistar party and the college of physicians of philadelphia. 20154551242
pattern of luteinizing hormone secretion during delayed implantation in the spotted skunk (spilogale putorius latifrons). 20154457150
a new dental superalloy system. 3. microstructure and phase transformations. 20154509488
induction of -globin synthesis in the -thalassaemia of ferrara. 20154505416
[atrio-ventricular canal]. 20154464964
[research on the cases of paralytic poliomyelitis and neurological syndromes observed in sicily during the 1st phase of the campaign of anti-poliomyelitis vaccination with attenuated viruses]. 20154386099
[proceedings: acth test using free urinary cortisol as an index]. 20154375581
resection of the inferior vena cava for adjacent malignant diseases. 20154349727
gastrointestinal reactions to drugs. 20154324432
[amputation neuroma of the abdominal pneumogastric nerve]. 20154335886
structure and function of proteins. 20154333476
impact of a large-scale narcotics treatment program: a six month experience. 20154713704
high concentration of 99mtc-sulfur colloid found during routine liver scan in lungs of patient with advanced breast cancer. 20154724344
injuries of the tarso-metatarsal joints. etiology, classification and results of treatment. 20154639441
[generalized follicular and ungual mucinosis]. 20154642849
[treatment of pott's disease in dakar]. 20154465050
[kinetics of hemoglobin. i. 2,3 dpg]. 20154677097
the peripheral blood standard values in newborns in bandung. 20154639612
patterns of acculturation in new immigrants. 20154518328
a simplified technique for resecting aortic arch aneurysms distal to the innominate artery. a case report. 20154572520
the senile tremor patient. 20154524036
psychological tests: their use and validity in selecting candidates for schools of nursing in israel. 20154496609
[determination of 11-ohcs in the blood by using fluorescence]. 20154475880
lethality in mice of double-stranded ribonucleic acid from virus-like particles of penicillium stoloniferum. 20154460287
[the continuing education of dental assistants]. 20154514277
letter: physicians as public speakers. 20154406955
non-filarial elephantiasis of the lower legs in ethiopia. a simple method for rapid survey by school enquiry. 20154693995
non-filarial elephantiasis of the lower legs in ethiopia. a simple method for rapid survey by school enquiry. 20154693995
largest award for medical negligence. 20154685647
[serial hemocultures with warren's medium in patients with positive machado-guerreiro reaction]. 20154624192
[60th birthday of wolf-dietrich eichler]. 20154601674
[prospects in the clinical use of ketamine chlorhydrate in pediatric orthopedics and traumatology]. 20154598394
[dr. gustaw doliński (1864-1906), honorary member of the lublin medical society]. 20154598401
[relation between malocclusion and supernumerary teeth]. 20154514713
some observations on secretory cells of nasopharynx using time-lapse cinemicrography. 20154571855
immunohistologic observations in mesangioproliferative glomerulonephritis. 20154536443
[rooming-in]. 20154499417
[hepatitis morbidity following heart surgery]. 20154539568
[enzymatic thin layer chromatography for the identification of some organophosphorous pesticides]. 20154446338
immobilon in the otter. 20154450432
absorption of 5.47 mev alpha particles by membrane filter material. 20154436056
lymphocyte responsiveness to phytohemagglutinin (pha): quantitative aspects and reproducibility. 20154455894
[the effect of quateleron on the filtration-reabsorption function of the kidneys and electrolyte (sodium and potassium) metabolism in hypertension]. 20154390376
a neuralizing influence of dibutyryl cyclic amp on competent chick ectoderm. 20154365011
[program of school preventive pedodontics]. 20154527504
cytologic and histologic aspects of toxically induced liver reactions. 20154774698
cavitary bronchiolar carcinoma. 20154313110
survey on antimicrobial resistance patterns in vibrio vulnificus and vibrio cholerae non-o1/non-o139 in germany reveals carbapenemase-producing vibrio cholerae in coastal waters.an increase in the occurrence of potentially pathogenic vibrio species is expected for waters in northern europe as a consequence of global warming. in this context, a higher incidence of vibrio infections is predicted for the future and forecasts suggest that people visiting and living at the baltic sea are at particular risk. this study aimed to investigate antimicrobial resistance patterns among vibrio vulnificus and vibrio cholerae non-o1/non-o139 isolates that could pose a public health ris ...201526579088
rapid proliferation of vibrio parahaemolyticus, vibrio vulnificus, and vibrio cholerae during freshwater flash floods in french mediterranean coastal lagoons.vibrio parahaemolyticus, vibrio vulnificus, and vibrio cholerae of the non-o1/non-o139 serotype are present in coastal lagoons of southern france. in these mediterranean regions, the rivers have long low-flow periods followed by short-duration or flash floods during and after heavy intense rainstorms, particularly at the end of the summer and in autumn. these floods bring large volumes of freshwater into the lagoons, reducing their salinity. water temperatures recorded during sampling (15 to 24° ...201526319881
occurrence of vibrio parahaemolyticus, vibrio cholerae, and vibrio vulnificus in the aquacultural environments of taiwan.the occurrence of vibrio parahaemolyticus, vibrio vulnificus, and vibrio cholerae in a total of 72 samples from six aquaculture ponds for groupers, milk fish, and tilapia in southern taiwan was examined by the membrane filtration and colony hybridization method. the halophilic v. parahaemolyticus was only recovered in seawater ponds, with a high isolation frequency of 86.1% and a mean density of 2.6 log cfu/g. v. cholerae was found in both the seawater and freshwater ponds but preferentially in ...201525951392
differential specificity of selective culture media for enumeration of pathogenic vibrios: advantages and limitations of multi-plating methods.plating environmental samples on vibrio-selective chromogenic media is a commonly used technique that allows one to quickly estimate concentrations of putative vibrio pathogens or to isolate them for further study. although this approach is convenient, its usefulness depends directly on how well the procedure selects against false positives. we tested whether a chromogenic medium, chromagar vibrio (cav), used alone (single-plating) or in combination (double-plating) with a traditional medium thi ...201525602161
prevalence and antimicrobial resistance of vibrio spp. in retail and farm shrimps in ecuador.the aim of this study was to investigate the prevalence of vibrio spp. in shrimp at retail and in shrimp farms in ecuador and to determine the antimicrobial agent resistance patterns of farm isolates. the presence of genes linked to early mortality syndrome (ems) or acute hepatopancreatic necrosis disease (ahpnd) also was evaluated. vibrio spp. were isolated from retail shrimps in cuenca, ecuador, and farm shrimps originating from provinces el oro and guayas, ecuador. a total of 229 shrimp sampl ...201526555534
deep-sea hydrothermal vent bacteria related to human pathogenic vibrio species.vibrio species are both ubiquitous and abundant in marine coastal waters, estuaries, ocean sediment, and aquaculture settings worldwide. we report here the isolation, characterization, and genome sequence of a novel vibrio species, vibrio antiquarius, isolated from a mesophilic bacterial community associated with hydrothermal vents located along the east pacific rise, near the southwest coast of mexico. genomic and phenotypic analysis revealed v. antiquarius is closely related to pathogenic vibr ...201525964331
nmr study of the o-specific polysaccharide and the core oligosaccharide from the lipopolysaccharide produced by plesiomonas shigelloides o24:h8 (strain cnctc 92/89).the structures of the o-specific polysacccharide and core oligosaccharide of the lipopolysaccharide from plesiomonas shigelloides o24:h8, strain cnctc 92/89, have been investigated by nmr spectroscopy and esi mass spectrometry. the o-specific polysaccharide was found to be composed of a tetrasaccharide repeating unit consisting of [→3)-α-fucpnac-(1→3)-α-galpnaca-(1→3)-α-quipnac-(1→] and of α-rhapnac (1→4) linked to the galpnaca residue. an identical structure has been reported for the capsular p ...201525834986
zebrafish fed on recombinant artemia expressing epinecidin-1 exhibit increased survival and altered expression of immunomodulatory genes upon vibrio vulnificus infection.artemia has been used extensively in aquaculture as fodder for larval fish, shrimp, and shellfish. epinecidin-1, an antimicrobial peptide, was isolated from grouper (epinephelus coioides) in 2005. epinecidin-1 has been previously reported to possess antimicrobial activity against several gram-positive and gram-negative bacterial species, including staphylococcus coagulase, pseudomonas aeruginosa, streptococcus pyogenes, and vibrio vulnificus. in this study, we used electroporation to introduce p ...201525462461
novel host-specific iron acquisition system in the zoonotic pathogen vibrio vulnificus.vibrio vulnificus is a marine bacterium associated with human and fish (mainly farmed eels) diseases globally known as vibriosis. the ability to infect and overcome eel innate immunity relies on a virulence plasmid (pvvbt2) specific for biotype 2 (bt2) strains. in the present study, we demonstrated that pvvbt2 encodes a host-specific iron acquisition system that depends on an outer membrane receptor for eel transferrin called vep20. the inactivation of vep20 did not affect either bacterial growt ...201525630302
hydrogen peroxide causes vibrio vulnificus bacteriolysis accelerated by sulfonyl fluoride compounds.induction of bacteriolysis of vibrio vulnificus cells by 10 mm hydrogen peroxide (h(2)o(2)) was analyzed. all vibrio species examined, except for vibrio hollisae, were lysed by 10 mm h(2)o(2). bacteriophage induction was not the cause of h(2)o(2)-induced bacteriolysis. autolysis is also known to cause bacteriolysis. vvps protein is a serine protease of v. vulnificus essential for autolysis. vvps mutant underwent h(2)o(2)-induced bacteriolysis in the same manner as the wild type. protease inhibit ...201526316164
the infectious and noninfectious dermatological consequences of flooding: a field manual for the responding provider.meteorological data show that disastrous floods are increasingly frequent and more severe in recent years, perhaps due to climatic changes such as global warming. during and after a flood disaster, traumatic injuries, communicable diseases, chemical exposures, malnutrition, decreased access to care, and even mental health disorders dramatically increase, and many of these have dermatological manifestations. numerous case reports document typical and atypical cutaneous infections, percutaneous tr ...201526159354
bacterial zoonoses of fishes: a review and appraisal of evidence for linkages between fish and human infections.human contact with and consumption of fishes presents hazards from a range of bacterial zoonotic infections. whereas many bacterial pathogens have been presented as fish-borne zoonoses on the basis of epidemiological and phenotypic evidence, genetic identity between fish and human isolates is not frequently examined or does not provide support for transmission between these hosts. in order to accurately assess the zoonotic risk from exposure to fishes in the context of aquaculture, wild fisherie ...201525466575
evaluation of ice slurries as a control for postharvest growth of vibrio spp. in oysters and potential for filth contamination.raw oyster consumption is the most common route of exposure for vibrio spp. infections in humans. vibriosis has been increasing steadily in the united states despite efforts to reduce the incidence of the disease. research has demonstrated that ice is effective in reducing postharvest vibrio spp. growth in oysters but has raised concerns of possible contamination of oyster meat by filth (as indicated by the presence of fecal coliform bacteria or clostridium perfringens). this study examined the ...201526197291
vibrio spp. from macrobrachium amazonicum prawn farming are inhibited by moringa oleifera extracts.to investigate the in vitro antimicrobial potential of extracts of stem, leaves, flowers, pods and seeds of moringa oleifera (m. oleifera) against vibrio spp. from hatchery water and the prawn macrobrachium amazonicum.201526614991
ttrap is a critical factor in grouper immune response to virus infection.ttrap (traf and tnf receptor-associated protein) is latest identified cytosolic protein that serves as a negative regulator for tnf signaling pathway. in this study, a member of tnf superfamily, ttrap gene (designed as ecttrap) was cloned from grouper, epinephelus coioides. there was an exo_endo_phos type domain in ecttrap, and it was well conserved when compared with other ttraps, especially the endonuclease activity related motifs. ecttrap exhibited prominent endonuclease activity against the ...201526172204
vibrio vulnificus glycogen branching enzyme preferentially transfers very short chains: n1 domain determines the chain length transferred.the glycogen branching enzyme from vibrio vulnificus (vvgbe) transfers short side chains (dp 3-5) significantly greater than any other bacterial glycogen branching enzyme (gbe). to elucidate the role of the n-domain of vvgbe in the unique branching pattern, domain-truncated (n1 and n) and n1-domain-swapped (with vvgbe n1 replacing the counter part of escherichia coli gbe) mutants were constructed. the truncation mutants synthesized branched products with a greatly reduced proportion of short cha ...201525819440
hygiene and health risks associated with the consumption of edible lamellibranch molluscs.edible lamellibranch molluscs are frequently the cause of very serious outbreaks of food poisoning. microbiological suitability for human consumption, according to ec reg. n. 1441/2007, is only based on two faecal bacteriological contamination parameters (escherichia coli and salmonella) and does not consider other microorganisms which are naturally present within the marine environment and are potentially pathogenic such as those belonging to the genus vibrio. in this study, a total of 540 samp ...201525744696
functional analysis of vibrio vulnificus rnd efflux pumps homologous to vibrio cholerae vexab and vexcd, and to escherichia coli acrab.resistance-nodulation-division (rnd) efflux pumps are associated with multidrug resistance in many gram-negative pathogens. the genome of vibrio vulnificus encodes 11 putative rnd pumps homologous to those of vibrio cholerae and escherichia coli. in this study, we analyzed three putative rnd efflux pumps, showing homology to v. cholerae vexab and vexcd and to e. coli acrab, for their functional roles in multidrug resistance of v. vulnificus. deletion of the vexab homolog resulted in increased su ...201525740377
histidine phosphocarrier protein regulates pyruvate kinase a activity in response to glucose in vibrio vulnificus.the bacterial phosphoenolpyruvate:sugar phosphotransferase system (pts) consists of two general energy-coupling proteins [enzyme i and histidine phosphocarrier protein (hpr)] and several sugar-specific enzyme iis. although, in addition to the phosphorylation-coupled transport of sugars, various regulatory roles of pts components have been identified in escherichia coli, much less is known about the pts in the opportunistic human pathogen vibrio vulnificus. in this study, we have identified pyruv ...201525598011
the cababc operon essential for biofilm and rugose colony development in vibrio vulnificus.a transcriptome analysis identified vibrio vulnificus cababc genes which were preferentially expressed in biofilms. the cababc genes were transcribed as a single operon. the caba gene was induced by elevated 3',5'-cyclic diguanylic acid (c-di-gmp) and encoded a calcium-binding protein caba. comparison of the biofilms produced by the caba mutant and its parent strain jn111 in microtiter plates using crystal-violet staining demonstrated that caba contributed to biofilm formation in a calcium-depen ...201526406498
the makes caterpillars floppy (mcf)-like domain of vibrio vulnificus induces mitochondrion-mediated apoptosis.the multifunctional-autoprocessing repeats-in-toxin (martxvv) toxin of vibrio vulnificus plays a significant role in the pathogenesis of this bacterium through delivery of up to five effector domains to the host cells. previous studies have established that the martxvv toxin is linked to v. vulnificus dependent induction of apoptosis, but the region of the large multifunction protein essential for this activity was not previously identified. recently, we showed that the makes caterpillar floppy- ...201526351282
distinct roles of the repeat-containing regions and effector domains of the vibrio vulnificus multifunctional-autoprocessing repeats-in-toxin (martx) toxin.vibrio vulnificus is a seafood-borne pathogen that destroys the intestinal epithelium, leading to rapid bacterial dissemination and death. the most important virulence factor is the multifunctional-autoprocessing repeats-in-toxin (martx) toxin comprised of effector domains in the center region flanked by long repeat-containing regions which are well conserved among martx toxins and predicted to translocate effector domains. here, we examined the role of the repeat-containing regions using a modi ...201525827415
genotypic diversity and population structure of vibrio vulnificus strains isolated in taiwan and korea as determined by multilocus sequence typing.the genetic diversity and population structure of vibrio vulnificus isolates from korea and taiwan were investigated using pcr-based assays targeting putative virulence-related genes and multilocus sequence typing (mlst). box-pcr genomic fingerprinting identified 52 unique genotypes in 84 environmental and clinical v. vulnificus isolates. the majority (> 50%) of strains had pathogenic genotypes for all loci tested; moreover, many environmental strains had pathogenic genotypes. although significa ...201526599487
induced autoprocessing of the cytopathic makes caterpillars floppy-like effector domain of the vibrio vulnificus martx toxin.the multifunctional-autoprocessing repeats-in-toxin (martx(vv)) toxin that harbours a varied repertoire of effector domains is the primary virulence factor of vibrio vulnificus. although ubiquitously present among biotype i toxin variants, the 'makes caterpillars floppy-like' effector domain (mcf(vv)) is previously unstudied. using transient expression and protein delivery, mcf(vv) and mcf(ah) from the aeromonas hydrophila martx(ah)) toxin are shown for the first time to induce cell rounding. al ...201525912102
role of acsr in expression of the acetyl-coa synthetase gene in vibrio vulnificus.vars/vara is one of the global factors regulating diverse aspects of the metabolism and virulence of bacteria including pathogenic vibrio spp. an experiment to identify the vars/vara-regulon in v. vulnificus revealed that a putative luxr-type transcriptional regulator was down-regulated in δvara mutant. to investigate the roles of this regulatory cascade, the target gene regulated by a luxr-regulator was identified and its expression was characterized.201525887971
identification of the target dna sequence and characterization of dna binding features of hlyu, and suggestion of a redox switch for hlya expression in the human pathogen vibrio cholerae from in silico studies.hlyu, a transcriptional regulator common in many vibrio species, activates the hemolysin gene hlya in vibrio cholerae, the rtxa1 operon in vibrio vulnificus and the genes of plp-vah1 and rtxachbde gene clusters in vibrio anguillarum. the protein is also proposed to be a potential global virulence regulator for v. cholerae and v. vulnificus. mechanisms of gene control by hlyu in v. vulnificus and v. anguillarum are reported. however, detailed elucidation of the interaction of hlyu in v. cholerae ...201525605793
actin-directed toxin. acd toxin-produced actin oligomers poison formin-controlled actin polymerization.the actin cross-linking domain (acd) is an actin-specific toxin produced by several pathogens, including life-threatening spp. of vibrio cholerae, vibrio vulnificus, and aeromonas hydrophila. actin cross-linking by acd is thought to lead to slow cytoskeleton failure owing to a gradual sequestration of actin in the form of nonfunctional oligomers. here, we found that acd converted cytoplasmic actin into highly toxic oligomers that potently "poisoned" the ability of major actin assembly proteins, ...201526228148
a novel recombinant bivalent outer membrane protein of vibrio vulnificus and aeromonas hydrophila as a vaccine antigen of american eel (anguilla rostrata).the immogenicity of a novel vaccine antigen was evaluated after immunized american eels (anguilla rostrata) with a recombinant bivalent expressed outer membrane protein (omp) of vibrio vulnificus and aeromonas hydrophila. three groups of eels were intraperitoneal (i.p) injected with phosphate-buffered saline (pbs group), formaline-killed-whole-cell (fkc) of a. hydrophila and v. vulnificus (fkc group) or the bivalent omp (omp group). on 14, 21, 28 and 42 days post-vaccination respectively, prolif ...201525655329
the immediate global responses of aliivibrio salmonicida to iron limitations.iron is an essential micronutrient for all living organisms, and virulence and sequestration of iron in pathogenic bacteria are believed to be correlated. as a defence mechanism, potential hosts therefore keep the level of free iron inside the body to a minimum. in general, iron metabolism is well studied for some bacteria (mostly human or animal pathogens). however, this area is still under-investigated for a number of important bacterial pathogens. aliivibrio salmonicida is a fish pathogen, an ...201525649684
role of anaerobiosis in capsule production and biofilm formation in vibrio vulnificus.vibrio vulnificus, a pervasive human pathogen, can cause potentially fatal septicemia after consumption of undercooked seafood. biotype 1 strains of v. vulnificus are most commonly associated with human infection and are separated into two genotypes, clinical (c) and environmental (e), based on the virulence-correlated gene. for ingestion-based vibriosis to occur, this bacterium must be able to withstand multiple conditions as it traverses the gastrointestinal tract and ultimately gains entry in ...201525404024
role of the histone-like nucleoid structuring protein (h-ns) in the regulation of virulence factor expression and stress response in vibrio vulnificus.temperature is one of the important parameters regulating the expression of virulence factors in bacteria. the global regulator, a histone-like nucleoid structuring protein (h-ns), is known to play a crucial role in this regulation. in the present study, we first clarified the role of h-ns in the temperature-dependent regulation of virulence factor production in vibrio vulnificus, including that of the cytolytic toxin (v. vulnificus hemolysin: vvh) and the proteolytic enzyme (v. vulnificus prote ...201526699858
virulence profiles of vibrio vulnificus in german coastal waters, a comparison of north sea and baltic sea isolates.vibrio vulnificus is a halophilic bacterium of coastal environments known for sporadically causing severe foodborne or wound infections. global warming is expected to lead to a rising occurrence of v. vulnificus and an increasing incidence of human infections in northern europe. so far, infections in germany were exclusively documented for the baltic sea coast, while no cases from the north sea region have been reported. regional variations in the prevalence of infections may be influenced by di ...201526694432
septic arthritis and subsequent fatal septic shock caused by vibrio vulnificus infection.vibrio vulnificus is a rare but potential fatal bacterium that can cause severe infections. wound infections, primary sepsis and gastroenteritis are the most common clinical features. septic arthritis caused by v. vulnificus is an atypical presentation that has been reported in only two case reports; however, it has not been previously noted in denmark. the authors report a case of septic arthritis caused by v. vulnificus in an immunocompromised patient. the disease progressed to severe sepsis a ...201526604231
transgenic expression of omega-3 pufa synthesis genes improves zebrafish survival during vibrio vulnificus infection.highly desaturated n-3 polyunsaturated fatty acids (pufas), such as eicosapentaenoic acid (epa) and docosahexaenoic acid (dha), are synthesized by desaturases and elongase. they exert hepatoprotective effects to prevent alcoholic fatty liver syndrome or cholestatic liver injury. however, it is unclear how n-3 pufas improve immune function in liver. vibrio vulnificus, a gram-negative bacterial pathogen, causes high mortality of aquaculture fishes upon infection. humans can become infected with v. ...201526572495
sediment and vegetation as reservoirs of vibrio vulnificus in the tampa bay estuary and gulf of mexico.the opportunistic pathogen vibrio vulnificus occurs naturally in estuarine habitats and is readily cultured from water and oysters under warm conditions but infrequently at ambient conditions of <15°c. the presence of v. vulnificus in other habitats, such as sediments and aquatic vegetation, has been explored much less frequently. this study investigated the ecology of v. vulnificus in water by culture and quantitative pcr (qpcr) and in sediment, oysters, and aquatic vegetation by culture. v. vu ...201525636843
ph level as a marker for predicting death among patients with vibrio vulnificus infection, south korea, 2000-2011.vibrio vulnificus infection can progress to necrotizing fasciitis and death. to improve the likelihood of patient survival, an early prognosis of patient outcome is clinically important for emergency/trauma department doctors. to identify an accurate and simple predictor for death among v. vulnificus-infected persons, we reviewed clinical data for 34 patients at a hospital in south korea during 2000-2011; of the patients, 16 (47%) died and 18 (53%) survived. for nonsurvivors, median time from ho ...201525627847
role of hemf and hemn in the heme biosynthesis of vibrio vulnificus under s-adenosylmethionine-limiting conditions.vibrio vulnificus contains two coproporphyrinogen iii oxidases (cpos): o2-dependent hemf and o2-independent hemn. the growth of the hemf mutant hf1 was similar to wild-type cells at ph 7.5 under 2% o2 conditions where hemn was active and had a half-life of 64 min. however, hf1 did not grow when the medium ph decreased to ph 5.0, where oxidative stress affects endogenous s-adenosylmethionine (sam) levels. the growth of hf1 was restored not only by elevating the expression of mnsod but also throug ...201525626927
early steps in the european eel (anguilla anguilla)-vibrio vulnificus interaction in the gills: role of the rtxa13 toxin.vibrio vulnificus is an aquatic gram-negative bacterium that causes a systemic disease in eels called warm-water vibriosis. natural disease occurs via water born infection; bacteria attach to the gills (the main portal of entry) and spread to the internal organs through the bloodstream, provoking host death by haemorrhagic septicaemia. v. vulnificus produces a toxin called rtxa13 that hypothetically interferes with the eel immune system facilitating bacterial invasion and subsequent death by sep ...201525613341
multiplex pcr for detection of virulence markers of vibrio vulnificus.vibrio vulnificus is a gram-negative pathogen found in coastal and estuarine waters worldwide that can cause life threatening diseases. characterization of the vcg (virulence correlated gene) or 16s rrna alleles is used to distinguish virulent (clinical (c)-type) from presumably avirulent (environmental (e)-type) strains. however, some studies reported a significant number of clinical strains belonging to the e-type. in recent years more potential virulence markers have been identified, that are ...201525604517
draft genome sequences of four closely linked vibrio vulnificus isolates from the biotype 1 environmental genotype.biotype 1 of vibrio vulnificus, which causes severe invasive intestinal and wound infections, is split into two genotypes with all previously sequenced clinical isolates from the c genotypes. we report here the whole-genome sequencing of two clinical isolates and two closely linked oyster isolates from the e genotype for comparative studies.201525593245
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