Publications

a look back at an ongoing problem: shigella dysenteriae type 1 epidemics in refugee settings in central africa (1993-1995).	shigella dysenteriae type 1 (sd1) is a cause of major dysentery outbreaks, particularly among children and displaced populations in tropical countries. although outbreaks continue, the characteristics of such outbreaks have rarely been documented. here, we describe the sd1 outbreaks occurring between 1993 and 1995 in 11 refugee settlements in rwanda, tanzania and democratic republic of the congo (drc). we also explored the links between the different types of the camps and the magnitude of the o ...	2009	19214226
the expression of lipopolysaccharide by strains of shigella dysenteriae, shigella flexneri and shigella boydii and their cross-reacting strains of escherichia coli.	strains of shigella dysenteriae, shigella flexneri and shigella boydii express lipopolysaccharides, that enable the serotyping of strains based on their antigenic structures. certain strains of s. dysenteriae, s. flexneri and s. boydii are known to share epitopes with strains of escherichia coli; however, the lipopolysaccharide profiles of the cross-reacting organisms have not been compared by sodium dodecyl sulfate polyacrylamide gel electrophoresis (sds-page) lipopolysaccharides profiling. in ...	2009	19222579
structure and heme binding properties of escherichia coli o157:h7 chux.	for many pathogenic microorganisms, iron acquisition from host heme sources stimulates growth, multiplication, ultimately enabling successful survival and colonization. in gram-negative escherichia coli o157:h7, shigella dysenteriae and yersinia enterocolitica the genes encoded within the heme utilization operon enable the effective uptake and utilization of heme as an iron source. while the complement of proteins responsible for heme internalization has been determined in these organisms, the f ...	2009	19319934
expression, purification, crystallization and preliminary x-ray diffraction analysis of the tonb-dependent haem outer membrane transporter shua from shigella dysenteriae.	as part of efforts towards understanding the crystallization of membrane proteins and membrane transport across the outer membrane of gram-negative bacteria, the tonb-dependent haem outer membrane transporter shua of shigella dysenteriae bound to heavy atoms was crystallized in several crystallization conditions using detergents. the insertion of a his(6) tag into an extracellular loop of shua, instead of downstream of the escherichia coli peptide signal, allowed efficient targeting to the outer ...	2009	19342792
synthesis, characterization, and immunogenicity in mice of shigella sonnei o-specific oligosaccharide-core-protein conjugates.	shigellosis, an enteric disease, is on the world health organization's priority prevention list. in one study, the shigella sonnei o-specific polysaccharide (o-sp)-protein conjugate showed 72% protection against disease in israeli army recruits exposed to high rates (8-14%) of infection. the protection was related to vaccine-induced igg anti-o-sp levels. synthetic oligosaccharides of shigella dysenteriae type 1, bound by their reducing ends to a carrier protein ("sun"-type configuration), induce ...	2009	19346477
[complete structure of the o-polysaccharide from shigella dysenteriae type 10].	the structure of the o-specific polysaccharide from shigella dysenteriae type 10, which has been reported previously in bioorg. khim. (1977, vol. 3, pp. 1219-1225), was refined: [formula: see text].	2009	19377533
antimicrobial activity of the methanolic extract and compounds from morus mesozygia stem bark.	this study was aimed at investigating the antimicrobial activity of the methanolic extract (mmb) and compounds isolated from the stem bark of morus mesozygia, namely 3beta-acetoxyurs-12-en-11-one (1), moracin q (2), moracin t (3), artocarpesin (4), cycloartocarpesin (5), moracin r (6), moracin u (8), moracin c (9), and moracin m (10).	2009	19450674
molecular detection of all 34 distinct o-antigen forms of shigella.	shigella is the cause of shigellosis or bacillary dysentery, the occurrence of which is estimated to be 165 million cases per year worldwide, resulting in 1.1 million deaths. rapid and reliable assays for detecting and identifying shigella in food, environmental and clinical samples are therefore necessary. shigella species are traditionally identified by their o antigens. this study developed a dna microarray targeting o-serotype-specific genes to detect all 34 distinct o-antigen forms of shige ...	2009	19074655
lactobacilli facilitate maintenance of intestinal membrane integrity during shigella dysenteriae 1 infection in rats.	lactobacilli are used in various dairy products and fermented foods for their potential health beneficial effects. recently we reported the protective role of lactobacillus rhamnosus and lactobacillus acidophilus during shigella dysenteriae 1 infection. nevertheless, investigations on the membrane-stabilizing effect of l. rhamnosus and l. acidophilus have not been done. hence, the present study evaluated the effect of l. rhamnosus and l. acidophilus on the maintenance of intestinal membrane inte ...	2009	19036564
selective ccr2-targeted macrophage depletion ameliorates experimental mesangioproliferative glomerulonephritis.	the ccl2/ccr2 chemokine/receptor axis directs the chemotaxis of infiltrating monocytes/macrophages and t cells and plays a pivotal role in tissue damage and fibrosis in kidney diseases. the eradication of the activated leucocytes should diminish the production of inflammatory mediators, limit tissue damage and ameliorate disease. a recombinant fusion protein (opl-ccl2-lpm) comprised of the human ccl2 (monocyte chemoattractant protein-1) chemokine fused to a truncated form of the enzymatically ac ...	2009	19040610
an outbreak of shigella dysenteriae in sweden, may-june 2009, with sugar snaps as the suspected source.	we report an outbreak of shigella dysenteriae type 2 infections during may-june 2009 in sweden, involving 47 suspected cases of whom 35 were laboratory-confirmed. the epidemiological investigation based on interviews with the patients pointed at sugar snaps from kenya as the source. shigella was not detected in samples of sugar snaps. however, escherichia coli was confirmed in three of four samples indicating contamination by faecal material. during april to may 2009 outbreaks with shigella conn ...	2009	19607782
study on induction of apoptosis on hela and vero cells by recombinant shiga toxin and its subunits.	verotoxin (vt) or shiga toxin (stx) produced by enterohemorrhagic escherichia coli (ehec) and shigella dysenteriae is ab5 holotoxin with potent protein synthesis inhibitor. vt can induce both apoptosis and necrosis depending on the cell type, it has been shown that vt-induced apoptosis and cytotoxicity are distinct processes, and the a subunit can be necessary for apoptosis. in other words, the precise role of each subunit in apoptosis signaling has yet to be established. in this study, inductio ...	2009	19669659
comparison of two label-free global quantitation methods, apex and 2d gel electrophoresis, applied to the shigella dysenteriae proteome.	the in vitro stationary phase proteome of the human pathogen shigella dysenteriae serotype 1 (sd1) was quantitatively analyzed in coomassie blue g250 (cbb)-stained 2d gels. more than four hundred and fifty proteins, of which 271 were associated with distinct gel spots, were identified. in parallel, we employed 2d-lc-ms/ms followed by the label-free computationally modified spectral counting method apex for absolute protein expression measurements. of the 4502 genome-predicted sd1 proteins, 1148 ...	2009	19563668
porin of shigella dysenteriae directly promotes toll-like receptor 2-mediated cd4+ t cell survival and effector function.	porin of shigella dysenteriae type 1 up-regulated toll-like receptor (tlr)2 on cd3-stimulated cd4(+) t cells but could not induce the expression of other tlrs. tlr2 in association with myeloid differentiating factor 88 (myd88) triggered the downstream signal transduction pathway leading to activation of mitogen-activated protein kinase (mapk) and nuclear factor kappab (nf-kappab), and degradation of ikappab, the nf-kappab inhibitor. tlr2 co-stimulation by porin resulted in t cell expansion by in ...	2009	19576636
bcl-2 regulates the onset of shiga toxin 1-induced apoptosis in thp-1 cells.	shiga toxins (stxs), which are proteins expressed by the enteric pathogens shigella dysenteriae serotype 1 and some serotypes of escherichia coli, are potent protein synthesis inhibitors. stx-producing organisms cause bloody diarrhea with the potential to progress to acute renal failure and central nervous system complications. studies using animal models of these diseases have shown that stxs are major virulence factors, and purified toxins have been shown to be capable of killing many types of ...	2009	19752028
the shigella dysenteriae serotype 1 proteome, profiled in the host intestinal environment, reveals major metabolic modifications and increased expression of invasive proteins.	shigella dysenteriae serotype 1 (sd1) causes the most severe form of epidemic bacillary dysentery. we present the first comprehensive proteome analysis of this pathogen, profiling proteins from bacteria cultured in vitro and bacterial isolates from the large bowel of infected gnotobiotic piglets (in vivo). overall, 1061 distinct gene products were identified. differential display analysis revealed that sd1 cells switched to an anaerobic energy metabolism in vivo. high in vivo abundances of amino ...	2009	19813213
association of water-borne diseases morbidity pattern and water quality in parts of ibadan city, nigeria.	occurrence of diarrhoea and other water-borne diseases in cities of developing countries has been on the increase over the decades largely due to unsafe water, inadequate sanitation and poor hygiene among human population. this study examined the relationship between the spatial pattern of water-borne diseases vis-a-vis water quality in parts of ibadan city in nigeria. data on 1334 cases of various water-borne diseases was collected from eight public hospitals with catchments covering the study ...	2009	20734698
inactivated and subunit vaccines to prevent shigellosis.	shigellosis remains a formidable disease globally, with children of the developing world bearing the greatest number of infections. the need for an affordable, safe and efficacious vaccine has persisted for decades. vaccines to prevent shigellosis can be divided into living and nonliving approaches. several nonliving shigella vaccines are currently at different stages of development and show substantial promise. outlined here is an overview of multiple nonliving vaccine technologies, highlightin ...	2009	19943764
diarrhea associated hemolytic uremic syndrome: a 3-year picu experience from nepal.		2009	20072865
acanthamoeba castellanii an environmental host for shigella dysenteriae and shigella sonnei.	the interaction between shigella dysenteriae or shigella sonnei and acanthamoeba castellanii was studied by viable counts, gentamicin assay and electron microscopy. the result showed that shigella dysenteriae or shigella sonnei grew and survived in the presence of amoebae for more than 3 weeks. gentamicin assay showed that the shigella were viable inside the acanthamoeba castellanii which was confirmed by electron microscopy that showed the shigella localized in the cytoplasm of the acanthamoeba ...	2009	18712360
guideline for the investigation and initial therapy of diarrhea-negative hemolytic uremic syndrome.	this guideline for the investigation and initial treatment of atypical hemolytic uremic syndrome (hus) is intended to offer an approach based on opinion, as evidence is lacking. it builds on the current ability to identify the etiology of specific diagnostic sub-groups of hus. hus in children is mostly due to infection, enterohemorrhagic escherichia coli (ehec), shigella dysenteriae type 1 in some geographic regions, and invasive streptococcus pneumoniae. these sub-groups are relatively straight ...	2009	18800230
simultaneous detection of enteric bacteria from surface waters by qpcr in comparison with conventional bacterial indicators.	a rapid quantitative polymerase chain reaction (qpcr) method was developed for simultaneous detection of enteric bacteria from surface waters by utilizing a pair of universal primers which targeted four bacteria strains, namely shigella dysenteriae, vibrio cholerae, salmonella typhimurium, and escherichia coli. it was estimated that the qpcr method had a 94% confidence, and a detection limit as 2.7 e. coli cells per sample in undiluted dna extracts. the qpcr method was applied for the bacteriolo ...	2009	18931927
[coagulation and fibrinolytic system of macrophages].		2009	2786578
[intraoperative management of emergency coronary artery bypass grafting].	intraoperative hemodynamics during emergency coronary artery bypass grafting (cabg) for acute evolving myocardial infarction (26 cases) were measured and compared with those during elective cabg (39 cases). before cardiopulmonary bypass period, it was strongly suggested that the cardiac function of emergency cases was worse than that of elective cases because of the following 5 factors; (1) hypotension, (2) tachycardia, (3) low stroke volume index, (4) pulmonary congestion and (5) metabolic acid ...	2009	2786576
cognitive and social-emotional development of children in different preschool environments.	62 english-speaking preschool children were divided into three groups, a montessori group (n = 21), a traditional preschool group (n = 21), and a homestaying group (n = 20) to compare their relative cognitive and social-emotional development. significant differences in favour of the school groups were found for vocabulary, language comprehension, ability to judge the correctness of figural stimuli, visual memory, and perceptual organization. no differences were found for social-emotional develop ...	2009	2798666
cognitive and social-emotional development of children in different preschool environments.	62 english-speaking preschool children were divided into three groups, a montessori group (n = 21), a traditional preschool group (n = 21), and a homestaying group (n = 20) to compare their relative cognitive and social-emotional development. significant differences in favour of the school groups were found for vocabulary, language comprehension, ability to judge the correctness of figural stimuli, visual memory, and perceptual organization. no differences were found for social-emotional develop ...	2009	2798666
[clinical significance of the quantification of obesity. the quetelet index and its use].	the degree of obesity, ie. the quantity of excessive stored adipose tissue, affects substantially morbidity and mortality on cardiovascular, metabolic, and other diseases. while the quantity of an adipose tissue is practically impossible to determine, it is necessary to use the body weight, adjusted for the stature. the quetelet's index (body mass index, bmi) is the best one from height-weight indices. values of bmi define categories of normal weight, overweight, and obesity, which have differen ...	2009	2790909
[a three years follow-up study on the blood pressures of 6111 children in chengdu].	this paper reports the results of a follow-up study in blood pressures of 6111 children for 3 years in chengdu city and the villages around. it was showed that the blood pressure for both the city and village children were elevated in overall with age. among the city children, the rate of bp-rising varied in different periods of childhood and that of girls above 13 was not significant. among village children, the rate of bp-rising for both male and female comparison to that of urban ones were si ...	2009	2736619
[characteristics of the course of the gestation period in patients with solitary kidney].	clinical biochemical, bacteriological investigations and functional tests were performed in 37 pregnant females with a solitary kidney. the status of fetoplacental system was studied as well. the investigators noted such common complications of pregnancy as the aggravation of renal inflammation, a high rate of caesarean section and postnatal morbidity. it was concluded that in case of pyelonephritic affection a solitary kidney the pregnancy should be terminated. if the infection was absent and t ...	2009	2817278
near-miss asphyxiation from a toy ball: a small parts failure.	the case report of a near-fatal asphyxiation of an 11-month-old child by a 26 mm (diameter) toy ball is presented. the lack of compliance with existing consumer product safety commission standards for small parts is discussed, and a recommendation is made regarding the coloring of ingestible objects.	2009	2710666
hodgkin's disease and non-hodgkin's lymphomas.		2009	2670408
a case of acute psychosis in temporal association with theophylline toxicity.		2009	2708558
griseofulvin and ketoconazole in the treatment of dermatophyte infections.		2009	2666321
pulmonary aspergillosis in immunosuppressed patients with haematological malignancies.	invasive pulmonary aspergillosis as a cause of mortality and morbidity in patients with haematological malignancies is becoming more common. predisposing factors are powerful immunosuppressive chemotherapy, neutropenia and synergistic combinations of antibiotics of great potency and wide spectrum of activity. clinical and radiological signs are heterogeneous, sometimes misleading and often absent. treatment is often empirical on suspicion alone. amphotericin b is the only effective drug but it h ...	2009	3749452
introduction to immunocytochemistry.	immunocytochemistry has opened a new era in research and diagnosis. the development of immunocytochemical methods has made it possible to identify in situ normal and pathological tissue constituents, which it has not been possible to detect using ordinary histological methods. however, immunocytochemical techniques involve several pitfalls, which without proper control protocols can easily lead to incorrect findings. when interpreting the results obtained, account must always be taken of the mor ...	2009	2664772
sonographic and pathological staging of patients with clinically localized prostate cancer.	we evaluated 64 patients with clinically localized prostate cancer (on the basis of rectal examination, serum acid phosphatase, bone scan and pelvic computerized tomography scan) by transrectal sonography before radical prostatectomy. of the 48 patients with histologically proved localized prostate cancer sonography overstaged the disease in 5 (10%) and correctly staged it in 43 (90%). all overstaged cancer patients were scanned after either prostatic biopsy (4) or transurethral prostatectomy (1 ...	2009	2681836
regulation of plasminogen activators and their inhibitors in rheumatic diseases: new understanding and the potential for new directions.	over the past several years there has been a rapid expansion in our understanding of the fibrinolytic system. this includes knowledge of the components, availability of recombinant reagents and a better understanding of the regulation of fibrinolysis in health and disease. disturbances in the regulation of the balance between fibrin deposition and removal have been implicated in a number of inflammatory diseases including certain rheumatic diseases. this overview summarizes our knowledge of the ...	2009	2681762
a sonographic and karyotypic study of second-trimester fetal choroid plexus cysts.	a prospective study was undertaken of 513 women between 15.6-24.1 weeks' gestation who had a level ii ultrasound examination followed immediately by a genetic amniocentesis. the presence or absence of fetal choroid plexus cysts was noted and the results correlated with the fetal karyotype. thirteen cases of choroid plexus cysts were observed sonographically, a prevalence of 2.5%. the size of the cysts ranged from 3-10 mm, with a median of 6 mm. there were no other sonographically detectable cong ...	2009	2649818
problems associated with the use of immediately dangerous to life and health (idlh) values for estimating the hazard of accidental chemical releases.	the possibility of accidental industrial chemical releases has generated considerable recent attention. one area requiring research for emergency planning is the development of safe exposure concentrations for the public in the event of an inadvertent release. the united states environmental protection agency (epa) has established a list of extremely hazardous substances and suggested that the toxicity ranking for 92 hazardous materials could be based on the "immediately dangerous to life or hea ...	2009	2688389
species differences in the pharmacology of terminal 5-ht autoreceptors in mammalian brain.		2009	2665245
structure-activity study of the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced neurotoxicity. ii. evaluation of the biological activity of the pyridinium metabolites formed from the monoamine oxidase-catalyzed oxidation of mptp analogs.	in the accompanying paper, several tetrahydropyridine analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) were screened for their abilities to be oxidized by monoamine oxidase (mao) to pyridiniums and to produce neurotoxicity in mice. we reported that most of the analogs were oxidized by mao to pyridiniums and some of the analogs were neurotoxic. we concluded that the capacity of a tetrahydropyridine mptp analog to be oxidized by mao to a pyridinium was a necessary, but not sufficient ...	2009	2786565
[osteolytic foci: cancer or not?].		2009	2797229
intraoperative staging in ovarian cancer.	in patients with early stage i or ii ovarian cancer a meticulous staging laparotomy is required; this should include omentectomy, pelvic and paraaortic lymphadenectomy, multiple peritoneal biopsies and diaphragmatic biopsies. adjunctive therapy is based on these surgical-pathological findings. in patients with advanced disease (stages iii and iv) it has been demonstrated that optimal tumour reduction enhances the length of survival. a complete resection of all gross disease in the abdominal cavi ...	2009	2661086
dislocated jaw.		2009	2742562
management of acute asthma.		2009	2713796
who issues report on heavy metal and pah compounds from municipal incinerators.		2009	2754439
[diagnosis and treatment of neuroblastoma in children--analysis of 98 patients].	from 1959 to 1982, 98 patients with neuroblastoma were treated in our hospital. seventy-eight were diagnosed by pathology and 69 (88.5%) were followed for 1 approximately 18 years. 50(51%) had already had distant metastasis (22, to bone) on admission. operation was performed on 53 patients (total excision on 18, partial excision on 11 and biopsy on 24 patients). the 1 and 15 year survival rates were 31.4% and 12.9%. the survival curve levelled off from the second year of the operation and remain ...	2009	3769741
[the importance of physiopathology in the management of peptic ulcer].		2009	2772478
spinal chronic subdural haematoma in a 7-year old girl.	a case is reported of chronic encapsulated spinal subdural haematoma which developed in a 7-year-old girl after minor spinal trauma. surgical removal of the lesion was followed by complete recovery.	2009	2792133
a simple procedure with nail preservation for ingrowing toe-nails.	the numerous methods used for treating ingrowing toe-nails are testimony to the lack of a generally acceptable procedure with a low failure rate. a simple procedure with nail preservation is described, and the results of treatment assessed. the procedure consists of making a transposition flap of the nail wall after preliminary curettage of the granulation tissue in the nail groove. a total of 82 patients were treated by this method over a 3-year period, and the results in 63 patients were asses ...	2009	4052211
a simple procedure with nail preservation for ingrowing toe-nails.	the numerous methods used for treating ingrowing toe-nails are testimony to the lack of a generally acceptable procedure with a low failure rate. a simple procedure with nail preservation is described, and the results of treatment assessed. the procedure consists of making a transposition flap of the nail wall after preliminary curettage of the granulation tissue in the nail groove. a total of 82 patients were treated by this method over a 3-year period, and the results in 63 patients were asses ...	2009	4052211
determination of plasma homocysteine by high-performance liquid chromatography with fluorescence detection.	severe homocystinemia is frequently associated with vascular disease while the pathological consequences of moderate or slightly elevated plasma homocysteine are unknown. cobalamin and folate deficiencies may result in an elevation of plasma homocysteine. a sensitive and reproducible assay for total plasma homocysteine has been developed. the essential steps in the assay include (i) conversion of homocysteine disulfides to free homocysteine with borohydride reduction; (ii) conjugation of homocys ...	2009	2729575
penetrating eye injuries.	a review of all penetrating eye injuries treated at the manchester royal eye hospital over four years (1 january 1982-31 december 1985) was undertaken. a total of 202 penetrating eye injuries were seen of which 68 (34%) were in children under the age of 15 years. airgun, dart, and knife injuries accounted for 28 (41%) of the injuries. thirty seven patients (54%) achieved a good visual result (6/12 or better) and eight (12%) had enucleations. the period of inpatient treatment ranged from two to 1 ...	2009	2705791
pica: a clue to iron deficiency anemia.		2009	2716310
the primary care role in occupational health nursing.	primary care is a valid, legal responsibility of the practicing occupational health nurse and accounts for a high percentage of the occupational health nurse's daily activities when considered on a local, national, and international level. historically, the varying definitions of primary care presented have led to confusion among practitioners who are attempting to categorize their services. the author attempts to express a workable interrelationship among these numerous terms including, "primar ...	2009	2818762
captopril--nifedipine interaction in hypertension.	nifedipine, a calcium channel blocker exerts significant peripheral vasodilatory activity in hypertensive patients. it has been postulated that the antihypertensive effect of peripherally acting vasodilators is masked, by counter regulatory mechanism e.g. activation of renin-angiotensin aldosterone (raa) axis. the present work was undertaken to study the effect of blockade of raa axis using captopril, an angiotensin converting enzyme inhibitor on the blood pressure lowering activity of nifedipin ...	2009	2681136
any more cordials to the drooping spirit? professional ethics, 1847-1989.		2009	2636862
[clinico-pathogenetic correlations in acute infectious diarrhea].		2009	2675261
regional pain syndrome.		2009	2790410
pure red cell aplasia with hypogammaglobulinemia appearing after thymectomy: a possible role for serum and cellular factors.		2009	3131206
meiotic recombination between two polymorphic restriction sites within the beta globin gene cluster.	analysis of beta globin gene haplotypes for prenatal diagnosis of beta thalassaemia has revealed a recombination event within the beta globin gene cluster. both a change in the avaii polymorphic site within the beta globin gene and a change in the phenotype of the beta globin gene were observed. paternity was established by the pedigree analysis of hypervariable 'minisatellite' dna polymorphisms and the most probable explanation of the recombination event is a crossover between the psi beta glob ...	2010	3005579
[193 cases of gastroschisis and omphalocele--postoperative results].	treatment was applied to 97 cases of omphalocele and 96 cases of gastroschisis at the dortmund department of paediatric surgery over the past 20 years. the survival rate was 122. follow-up checks were recently applied to 56 of those former patients, after nearly ten years had elapsed from surgery. thirty-eight of these patients were clinically examined, while questionnaires were completed for the rest. primary closures had been performed on 50 per cent of the cases, while the defects in the othe ...	2010	2966527
five coping styles in families of children with cancer: a retrospective study in thirty families.	this retrospective study concerned the coping behavior of 30 children with cancer and their families. fifteen families with children who were considered "cured" and 15 families with children who had died of their disease were questioned in partly structured interviews. in accordance with the coping model of lazarus, the following five different styles of coping by the family were identified: experiencing the disease as challenge, as probation, as misfortune, as fate, and as punishment. the evalu ...	2010	3153243
pyrophosphate formation from acetyl phosphate and orthophosphate: evidence for heterogeneous catalysis.	the formation of [32p]pyrophosphate from acetyl phosphate and [32p]orthophosphate was studied under conditions in which phosphate-metal salts or acetyl phosphate-metal salts precipitate. in the absence of precipitates in purely aqueous media, the initial rate constant of transphosphorylation (kobs) was extremely small and the formation of pyrophosphate was detected only in the presence of calcium. in various combinations, conditions such as high ph, high concentrations of reactants, and the pres ...	2010	2845863
[reflections on 851 open heart operations at the institute of cardiology in abidjan].		2010	2826086
the use of dura mater allograft in the surgical repair of large defects of the abdominal wall.	the dura mater allograft is being used as an abdominal fascia substitute and major advantages are documented. it was used successfully in four patients at this institution, with a ten month follow-up period. its strength, durability, tissue tolerance, flexibility, ease of handling, nonallergenic property, availability and stability in the presence of infection make it a good graft to be used in the repair of large abdominal hernias. we are quite convinced that long term follow-up results will ve ...	2010	3160130
the use of dura mater allograft in the surgical repair of large defects of the abdominal wall.	the dura mater allograft is being used as an abdominal fascia substitute and major advantages are documented. it was used successfully in four patients at this institution, with a ten month follow-up period. its strength, durability, tissue tolerance, flexibility, ease of handling, nonallergenic property, availability and stability in the presence of infection make it a good graft to be used in the repair of large abdominal hernias. we are quite convinced that long term follow-up results will ve ...	2010	3160130
desirable standards of performance for therapeutic drug monitoring.	therapeutic drug monitoring is an important aspect of clinical chemistry for which no objective analytical goals yet exist. based on fundamental pharmacokinetic theory, and the current consensus strategy for analytical goal-setting for precision based upon biological variation, a theoretical model allows derivation of the goal that: analytical cv less than or equal to 1/4 [(2t/t - 1)/(2t/t + 1)] x 100%, where t is the time interval between doses, and t is the average elimination half-life. using ...	2010	3815803
the incidence of cardiac arrhythmias during intravenous digital subtraction angiography: a comparison of peripheral and central injections.	intravenous digital subtraction arteriography (iv-dsa) was carried out in 204 patients with arteriosclerotic peripheral vascular disease using the non-ionic contrast medium iopamidol 370. in 124 patients the injection was made into an antecubital vein and in 80 into the right atrium. rhythm strip electrocardiograms showed no significant difference in incidence or type of arrhythmias between either injection method (p greater than 0.95).	2010	2941437
anal duct carcinoma.		2010	2924675
abnormal systolic time intervals in obesity and their relationship with the amount of overweight.	we studied 17 severely obese subjects (age range 26 to 42 years), without hypertension, diabetes mellitus, angina, or clinical signs of heart failure or respiratory disease, and 16 age-matched control subjects. x-teleroentgenographic findings (transverse cardiac diameter and cardiothoracic ratio), blood pressure, and mechanocardiographic parameters were analyzed in both groups. by means of conventional simultaneous recordings of ecg, phonocardiogram, and carotid pulse (100 mm/sec), systolic time ...	2010	2943149
why does placebo improve severe limb ischaemia?		2010	2893161
[the treatment of severe, therapy-resistant depression using infusions of antidepressants].	infusion-therapy with antidepressants has been of value in severe as well as therapy resistant depressive states. in addition to doses lower than those used for oral treatment, a more rapid onset of therapeutic effect and a better tolerance, the beneficial effect seems also to depend on the setting in which the treatment takes place. infusion-therapy is a combined pharmacopsychotherapeutic procedure. next to infusion-treatment a pretreatment with neuroleptics is advised either via the oral or pa ...	2010	2922514
midazolam in the intensive care unit.		2010	3769775
plasma atrial natriuretic peptide concentrations during induction of anesthesia and acute volume loading in patients undergoing cardiac surgery.	induction of anesthesia with fentanyl for coronary artery bypass grafting decreased (p less than .05) plasma atrial natriuretic peptide (anp) concentrations from awake values in twelve patients. during a steady state of anesthesia before surgery, isotonic saline solution (10 ml/kg) was infused simultaneously with the elevation of the lower extremities in six patients, while six subjects served as controls receiving no volume loading and having no leg raising. the anp levels returned to the awake ...	2010	2980951
principles of the diagnostic system 'orfèvre' for computerized analysis in radiology.		2010	2980470
microbial lipids betrayed by their fossils.	novel families of microbial lipids have been betrayed by their molecular fossils. they comprise the very widespread and varied hopanoids, and 'orphan' lipids. membrane reinforcement appears to be universally achieved by these polyterpenoids; a hypothetical phylogenetic tree comprises the above, some postulated intermediates, bacterial carotenoids, cycloartenol, and finally cholesterol.	2010	3153170
lateral diffusion of specific antibodies bound to lipid monolayers on alkylated substrates.	we have measured the lateral mobility of fluoresceinated monoclonal igg antibodies bound specifically to a spin label lipid hapten in phospholipid monolayers supported on alkylated silicon oxide surfaces. dimyristoyl phosphatidylcholine and dipalmitoyl phosphatidylcholine monolayers containing 5 mol% of the lipid hapten were transferred by conventional langmuir-blodgett techniques onto substrates alkylated with hydrocarbon chains containing 10, 16, and 18 carbon atoms. we show that the diffusion ...	2010	3006037
lateral diffusion of specific antibodies bound to lipid monolayers on alkylated substrates.	we have measured the lateral mobility of fluoresceinated monoclonal igg antibodies bound specifically to a spin label lipid hapten in phospholipid monolayers supported on alkylated silicon oxide surfaces. dimyristoyl phosphatidylcholine and dipalmitoyl phosphatidylcholine monolayers containing 5 mol% of the lipid hapten were transferred by conventional langmuir-blodgett techniques onto substrates alkylated with hydrocarbon chains containing 10, 16, and 18 carbon atoms. we show that the diffusion ...	2010	3006037
surgical streams in the flow of health care financing. the role of surgery in national expenditures: what costs are controllable?	the dollar flow in united states medical care has been analyzed in terms of a six-level model; this model and the gross 1981 flow data are set forth. of the estimated $310 billion expended in 1981, it is estimated that $85-$95 billion was the "surgical stream", i.e., that amount expended to take care of surgical patients at a variety of institutional types and including ambulatory care and surgeons' fees. some of the determinants of surgical flow are reviewed as well as controllable costs and ca ...	2010	3918514
[prevention of the problems of alcoholism].		2010	2975175
recent advances and controversies in childhood renal osteodystrophy.	renal osteodystrophy starts very early in chronic renal failure. although vitamin d levels are normal in patients with 70-80% function, the levels are not appropriate to the prevailing biochemical milieu. renal osteodystrophy may contribute to renal growth failure but a correlation between the degree of renal osteodystrophy and growth failure is not observed. catch-up growth cannot be obtained over a longer period of time with vitamin d. the main reason for osteomalacia is al intoxication. alumi ...	2010	3153280
[the administration of calcium channel blockers in patients with cerebrovascular diseases].		2010	2922083
solvent interactions with n, n-dialkylnicotinamides and their effects on rotational barriers.	carbon-13 nuclear magnetic resonance techniques were employed to examine the effects of solvent environment on rotational barriers in a series of molecules structurally-related to the analeptic, nikethamide: n,n-dimethylnicotinamide, n,n-di-n-propylnicotinamide, and 1-nicotinoyl piperidine. total bandshape analysis was performed for the exchanging alkyl carbon resonances of these compounds as a function of temperature in four solvent systems: d2o, ch3od, ch3ch2od and cdcl3. the rate constants fo ...	2010	2937406
[fibrinolytic therapy of thromboembolic vascular occlusions: experiences based on 87 patients].		2010	2974192
[hormonal status of girls in the neutral, prepubertal and pubertal periods of life].		2010	2935044
outcome of early surgery after coronary angioplasty.	nineteen of 69 patients undergoing coronary angioplasty required immediate coronary surgery after the procedure. six of these operations were planned as a result of angioplasty that failed without producing any complication. the remaining 13 cases were operated upon because complications occurred during angioplasty. these were coronary artery dissection in four, occlusion in five, continuing severe spasm in two, tamponade in one, and in one other detachment of a guidewire tip. in these 13 cases ...	2010	2937432
ciprostene in patients with peripheral vascular disease (pvd). an open-label, tolerance trial.	epoprostenol (prostacyclin) has been studied with various success in patients with peripheral vascular disease (pvd). we investigated the tolerance of a new, stable prostacyclin derivative ciprostene (9-beta-methyl carbacyclin) in 9 pvd patients. the drug was infused intravenously for 8 hours a day, once a week for 4 consecutive weeks, at a dose of 120 ng/kg/min. there were 6 men and 3 women with a mean age of 63 years (42-78). the pvd was verified by arteriography (9 patients) and by clinical f ...	2010	3068680
hay fever treatments--which should be tried first?	a series of comparative trials on nine popular and pharmacologically distinct regimens for the treatment of hay fever was undertaken in the course of normal general practice in the pollen seasons of 1981-83. one hundred and forty doctors recruited 640 patients to assess the overall usefulness of the treatments on daily diaries. ;usefulness' was scored on a linear analogue scale weighing up the degree of hay fever symptoms during treatment, side effects and ease of use of the preparation.the regi ...	2010	2896796
bioactivity and immunoreactivity of tumour necrosis factor in cancer patients.		2010	2893076
validity of an operational definition for neurotic unipolar major depression.	after we reviewed the literature to identify the clinical and phenomenologic correlates of neurotic depression, we constructed a 6-item operational definition to distinguish neurotic unipolar major depressive disorder from non-neurotic major depression. the neurotic depressives were characterized by a low rate of abnormal dexamethasone suppression test (dst) results and a strong family history of alcoholism. neurotic depressives improved less than non-neurotic depressives during the index hospit ...	2010	2952692
uptake of 63ni2+ in the central and peripheral nervous system of mice after oral administration: effects of treatments with halogenated 8-hydroxyquinolines.	oral administration of 63ni2+ to mice resulted in higher levels of the metal in the sciatic nerves, the trigeminal ganglia, spinal nerve roots and the spinal cord than in the cerebellum and the frontal cortex. in the sciatic nerves, the trigeminal ganglia and the spinal nerve roots a high vascular permeability may explain the preferential uptake of the 63ni2+. the higher accumulation of the 63ni2+ in the spinal cord than in the examined structures of the brain may be related to a diffusion from ...	2010	2916242
continuous ecg monitoring of children with cancer receiving domperidone.	domperidone is an effective antiemetic for children receiving cytotoxic therapy. there have been reports of cardiac arrest in older patients associated with domperidone. we carried out continuous ecg monitoring of 18 children receiving domperidone intravenously in a dose of 1 mg/kg body weight. no serious dysrhythmias were noted during 379 h of recording. single premature beats, transient sinus pauses, and nodal block were occasionally associated with vomiting and were no more common than would ...	2010	3153247
arrhythmia or artifact?		2010	2916599
[screening of cancer, advantages and disadvantages].		2010	2916263
the ir-thy-1 concept: continuing saga.		2010	2876044
ptsd and suicide attempts by adolescents.		2010	2929769
exposure to benzodiazepines in utero.		2010	2884529
[hismanal--a new nonsoporific hay fever medication].		2010	2876531
consent and the young mother.		2010	2857392