Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| immunoglobulin a and cd8 t-cell mucosal immune defenses protect against intranasal infection with chlamydia pneumoniae. | chlamydia pneumoniae initiates infection in humans via the mucosal epithelia of the respiratory tract; therefore, immunity at this mucosal site is believed to be important to control infection with this pathogen. we compared the protective capacity of immunization in mice with two c. pneumoniae antigens, namely the major outer membrane protein (momp) and the heat shock protein 60 (hsp-60), against intranasal (i.n.) infection with the bacteria when given as protein or dna and when administered by ... | 2006 | 16499570 |
| inhibitory effect of heparan sulfate-like glycosaminoglycans on the infectivity of chlamydia pneumoniae in hl cells varies between strains. | glycosaminoglycans are known to participate in the attachment of several chlamydial strains. we studied the effect of heparin, enoxaparin, low-molecular-weight heparin, chondroitin sulfate a, and heparinase i on the infectivity of chlamydia pneumoniae strain cwl029 and two finnish isolates, kajaani 7 and parola, in an hl cell line which is epithelial in origin. two chlamydia trachomatis strains, l2 and e, were used for comparison. the infectivity of all c. pneumoniae strains and c. trachomatis s ... | 2006 | 16500132 |
| association of chlamydia pneumoniae and helicobacter pylori infection with angiographically demonstrated coronary artery disease. | 2006 | 16503271 | |
| chlamydia pneumoniae infection and ischemic heart disease in hemodialysis patients. | ischemic heart disease and other atherosclerotic complications are the prominent causes of death among hemodialyzed end-stage renal disease (esrd) patients and renal transplant recipients. numerous articles in recent years have raised the possibility of an infective factor, especially chlamydia pneumoniae, in the development of atherosclerosis and its complications. the aim of this study was to assess the incidence of chronic c pneumoniae infection and its association with ischemic heart disease ... | 2006 | 16504656 |
| chlamydia pneumoniae infection: an additional factor for chronic allograft rejection. | chronic rejection (chr) of organ allografts, one of the most significant problems in modern transplantation, is not fully understood. this study sought to evaluate the influence of selected parameters on late kidney transplant function. | 2006 | 16504677 |
| detection of simkania negevensis by culture, pcr, and serology in respiratory tract infection in cornwall, uk. | respiratory tract infections are often treated empirically without investigation to detect the aetiological agent, which may be a virus or a bacterium, including atypical pathogens such as chlamydophila pneumoniae or mycoplasma pneumoniae. recently, several types chlamydia-like intracellular bacteria have been detected in environmental samples and clinical specimens. little is known of their geographical distribution and potential pathogenicity. we describe the detection, by pcr and isolation in ... | 2006 | 16505289 |
| prospective surveillance for atypical pathogens in children with community-acquired pneumonia in japan. | a total of 141 children with community-acquired pneumonia (cap) were studied prospectively to determine the causative microorganisms. microbial investigations included examination of postnasal swabs, cultures, polymerase chain reaction (pcr), and serology. the atypical pathogens occurring most frequently were mycoplasma pneumoniae (58 patients [41.1%]), chlamydia pneumoniae (4 patients [2.8%]), and concurrent occurrence of both pathogens (1 patient [0.7%]). patients aged under 4 years showed a r ... | 2006 | 16506088 |
| [seropositivity for chlamydia pneumoniae in patients with primary biliary cirrhosis]. | primary biliary cirrhosis (pbc) is a chronic cholestatic liver disease characterized by inflammatory injury and bile duct destruction. recent studies suggest that chlamydia pneumoniae could be associated with the development of pbc. the aim of this study was to determine the seroprevalence of c. pneumoniae in a cohort of patients with pbc. | 2006 | 16507276 |
| etiologic diagnosis of adult bacterial pneumonia by culture and pcr applied to respiratory tract samples. | respiratory culture and multiplex pcr for streptococcus pneumoniae, haemophilus influenzae, mycoplasma pneumoniae, and chlamydophila pneumoniae were applied to sputum, nasopharyngeal swabs, and nasopharyngeal aspirates from 235 adult patients with community-acquired pneumonia and 113 controls. both culture and multiplex pcr performed well with the different samples and appear to be useful as diagnostic tools. | 2006 | 16455935 |
| 60-kda heat shock protein of chlamydia pneumoniae promotes a t helper type 1 immune response through il-12/il-23 production in monocyte-derived dendritic cells. | infection, in particular by chlamydia pneumoniae (cp), has been associated with atherosclerosis and coronary heart disease. immune reactions to heat shock proteins (hsps) have been advocated to link infection to atherosclerosis and its acute sequelae based on molecular mimicry with host hsps. we have here evaluated the role played by recombinant cp-hsp60 and cp-hsp10 for their ability to induce maturation of human monocyte-derived dendritic cells (mddc) and t cell polarization. cp-hsp60, but not ... | 2006 | 16460983 |
| the effect of infections and vaccinations on stroke risk. | there is increasing evidence that, in addition to conventional risk factors, acute and chronic infectious diseases increase the risk of stroke. acute infection, mainly respiratory, and both bacterial and viral infection, represent temporarily active trigger factors for cerebral ischemia. chronic infectious diseases that may increase the risk of stroke include periodontitis, chronic bronchitis and infections with microbial antigens, such as helicobacter pylori and chlamydia pneumoniae. from obser ... | 2006 | 16466297 |
| gene expression profiles of u937 human macrophages exposed to chlamydophila pneumoniae and/or low density lipoprotein in five study models using differential display and real-time rt-pcr. | many studies on atherosclerosis have indicated an association with chlamydophila pneumoniae, a respiratory intracellular pathogen that can infect bronchoalveolar macrophages, and be transported to sites of vascular injury. furthermore, the connection between low density lipoprotein (ldl), macrophages, foam cell formation, and atherosclerosis is well established. five study models were designed to mimic the early events in plaque formation, i.e. untreated u937 human macrophages as control; macrop ... | 2006 | 16466844 |
| chronic chlamydia pneumoniae infection and stroke in cameroon: a case-control study. | to determine the relationship between chronic chlamydia pneumoniae infection and stroke in cameroon. | 2006 | 16469962 |
| risk of ruling out severe acute respiratory syndrome by ruling in another diagnosis: variable incidence of atypical bacteria coinfection based on diagnostic assays. | severe acute respiratory syndrome (sars) caused the first epidemic of the 21st century and continues to threaten the global community. | 2006 | 16470249 |
| detection of chlamydia in the peripheral blood cells of normal donors using in vitro culture, immunofluorescence microscopy and flow cytometry techniques. | chlamydia trachomatis (ct) and chlamydia pneumoniae (cp) are medically significant infectious agents associated with various chronic human pathologies. nevertheless, specific roles in disease progression or initiation are incompletely defined. both pathogens infect established cell lines in vitro and polymerase chain reaction (pcr) has detected chlamydia dna in various clinical specimens as well as in normal donor peripheral blood monocytes (pbmc). however, chlamydia infection of other blood cel ... | 2006 | 16472397 |
| [antibodies to chlamydia pneumoniae in blood serum of patients with ischemic heart disease and presence of complicated lesions in coronary arteries]. | levels of igm, igg and iga antibodies to chlamydia pneumoniae were measured in 107 patients (age 33-75 years) with documented coronary atherosclerosis and 39 subjects with intact coronary arteries. rates of seropositivity to c. pneumoniae were 77.6 and 25.6% in patients and "healthy" subjects, respectively (p<0.05). seropositive (n=83) compared with seronegative (n=24) patients had higher prevalence of complicated lesions (p<0.05). | 2006 | 16474303 |
| do common infections cause stroke? | infections have long been recognized as a potential, if uncommon, cause of cerebrovascular disease. in recent years, with the growing recognition of the importance of inflammation in atherosclerosis, there has been renewed interest in the possibility that common infections may participate in the atherosclerotic process or lead to stroke through other mechanisms. specific organisms that have been implicated include chlamydia pneumoniae, herpes viruses, human immunodeficiency virus, helicobacter p ... | 2006 | 16479447 |
| [bacteriological profile of infectious endocarditis in the area of sfax (tunisia)]. | we performed a study to analyze epidemiological characteristics and bacteriological profile of infectious endocarditis (i.e) in the area of sfax (tunisia). we analyzed, retrospectively, all cases of i.e, according to duke criteria, hospitalized in the chu hédi chaker of sfax between january 1997 and december 2000. bacteriological investigation included blood culture, cardiac valve culture and serology. seventy-two cases of i.e were diagnosed. the average of age was 32.3 years. 47.3% of the patie ... | 2006 | 16479886 |
| development of a rapid real-time pcr assay for detection and quantification of four familiar species of chlamydiaceae. | chlamydiae are one of the causative agents of various diseases in animals and human beings, which include abortion, pneumonia, gastroenteritis, encephalomyelitis, conjunctivitis, arthritis and sexually transmitted diseases. much work has been carried out to attempt to develop an efficient pathogen detection strategy. here, we presented a chlamydiaceae-specific 23s rrna-based real-time pcr assay for simultaneous detection and quantification of four members of chlamydiaceae family, c. trachomatis, ... | 2006 | 16488188 |
| [the significance of chlamydia pneumoniae in selected neurologic disorders]. | chlamydia pneumoniae has recently been implicated in the pathogenesis of several neurological diseases. as an intracellular parasite with its unusual life cycle it is able to circumvent the immune system and to persist in the organism. it has the ability to modify the function of the infected cell and supposedly induce autoimmune reactions. these properties can make it pathogenic in several chronic neurological diseases including multiple sclerosis, atherosclerosis, stroke, alzheimer dementia an ... | 2006 | 16491568 |
| prevalence and persistence of antibodies to herpes viruses, chlamydia pneumoniae and helicobacter pylori in alaskan eskimos: the gocadan study. | the prevalence and persistence of antibodies against cytomegalovirus (cmv), herpes simplex virus types 1 (hsv1) and 2 (hsv2), helicobacter pylori and chlamydia pneumoniae were determined in alaskan eskimos. the study included 610 individuals (mean age 43 +/- 15 years; 45% males) participating in the genetics of coronary artery disease in alaska natives (gocadan) study. archived serum samples and those collected during the gocadan study were analysed for antibodies against the above pathogens by ... | 2006 | 16441448 |
| mouse model of respiratory chlamydia pneumoniae infection for a genomic screen of subunit vaccine candidates. | an inbred a/j mouse respiratory challenge model was validated for vaccine testing against chlamydia (c.) pneumoniae and used to screen the c. pneumoniae genome for vaccine candidates by expression library immunization (eli). biolistic delivery of genetic vaccine constructs elicited th2-like immunity that was associated with inefficient elimination of c. pneumoniae. delivery by injection elicited protective th1-like responses. since biolistic delivery of pools of orfs was used in first round scre ... | 2006 | 16434129 |
| rifalazil pretreatment of mammalian cell cultures prevents subsequent chlamydia infection. | chlamydia species are widely disseminated obligate intracellular pathogens that primarily cause urogenital, ocular, and respiratory infections. in these studies, we show that exposing mammalian cells to antibacterial agents prior to chlamydia inoculation protects the host cells against subsequent challenge by chlamydiae (the protective effect [pe]). rifalazil exhibited a considerably stronger pe than did azithromycin, rifampin, doxycycline, and ofloxacin. specifically, 0.002 microg/ml rifalazil ... | 2006 | 16436694 |
| seropositivity to chlamydia pneumoniae is associated with risk of first ischemic stroke. | serologic evidence of infection with chlamydia pneumoniae has been associated with cardiovascular disease, but its relationship with stroke risk remains uncertain. the objective of this study is to determine whether serological evidence of c pneumoniae infection is associated with risk of ischemic stroke. | 2006 | 16424371 |
| chlamydia pneumoniae, stroke, and serological associations: anything learned from the atherosclerosis-cardiovascular literature or do we have to start over again? | 2006 | 16424375 | |
| fate of chlamydophila pneumoniae in human monocyte-derived dendritic cells: long lasting infection. | earlier studies from this group demonstrated that chlamydophila pneumoniae co-localized with dendritic cells (dc) in temporal artery biopsies from patients with giant cell arteritis (gca). to investigate the interaction of dc with c. pneumoniae we employed an in vitro cell culture system of human monocyte derived dc. these dc were infected with c. pneumoniae and observed at regular time intervals up to 25 days post infection. chlamydiae were visualized inside dc by both confocal and electron mic ... | 2006 | 16427247 |
| inflammation and chlamydia pneumoniae infection correlate with the severity of peripheral arterial disease. | our aim was to investigate the association of inflammation and chlamydia pneumoniae infection with the presence and severity of peripheral arterial disease. | 2006 | 16427340 |
| arginine-dependent gene regulation via the argr repressor is species specific in chlamydia. | some, but not all, chlamydia spp. are predicted to encode a homolog of argr, a master regulatory molecule that modulates arginine biosynthesis and catabolism in bacteria in response to intracellular arginine levels. while genes for arginine biosynthesis are apparently missing in chlamydia, a putative arginine transport system encoded by glnp, glnq, and artj is present. we found that recombinant chlamydia pneumoniae argr functions as an arginine-dependent aporepressor that bound specifically to o ... | 2006 | 16428395 |
| rapidly progressive glomerulonephritis in a patient with chlamydia pneumoniae infection: a possibility of superantigenic mechanism of its pathogenesis. | herein we describe a case of a patient with rapidly progressive glomerulonephritis after chlamydia pneumoniae infection. an 88-year-old woman who had had c. pneumoniae infection two months previously was admitted to our hospital with complaints of dyspnea and generalized edema. laboratory tests revealed acute renal failure, polyclonal hypergammaglobulinemia, highly increased level of c-reactive protein, and hematoproteinuria. a renal biopsy revealed mesangial and endocapillary proliferative glom ... | 2006 | 16429842 |
| protective effect of doxycycline use on coronary artery disease? | the potential role of chlamydia pneumoniae infection in the pathogenesis of atherosclerosis has received increasing attention. the present study was conducted to test the hypothesis that use of doxycycline in doses prescribed in routine clinical practice for brucellosis, decreases the risk of coronary artery disease (cad). | 2006 | 16176834 |
| delivery of chlamydia pneumoniae to the vessel wall aggravates atherosclerosis in ldlr-/- mice. | the role of chlamydia pneumoniae in atherosclerosis is still debated. in this study a novel mouse model was applied to determine the direct impact of c. pneumoniae on the arterial wall and the development of atherosclerosis. | 2006 | 16112098 |
| chlamydia pneumoniae, harmful only for peripheral arteries? | 2006 | 16257071 | |
| differential expression of chlamydial signal transduction genes in normal and interferon gamma-induced persistent chlamydophila pneumoniae infections. | characteristic features of the persistent chlamydial developmental cycle, associated with chronic infections in both humans and animals, include the generation of non-replicative, morphologically aberrant bodies which are distinct from normal propagating reticulate bodies. previous studies have correlated these morphological and metabolic changes with differential expression of diverse functional subsets of chlamydial genes. to further investigate these correlations, we compared mrna expression ... | 2006 | 16269262 |
| a monoclonal antibody against a carbohydrate epitope in lipopolysaccharide differentiates chlamydophila psittaci from chlamydophila pecorum, chlamydophila pneumoniae, and chlamydia trachomatis. | lipopolysaccharide (lps) of chlamydophila psittaci but not of chlamydophila pneumoniae or chlamydia trachomatis contains a tetrasaccharide of 3-deoxy-alpha-d-manno-oct-2-ulopyranosonic acid (kdo) of the sequence kdo(2-->8)[kdo(2-->4)] kdo(2-->4)kdo. after immunization with the synthetic neoglycoconjugate antigen kdo(2-->8)[kdo(2-->4)]kdo(2-->4) kdo-bsa, we obtained the mouse monoclonal antibody (mab) s69-4 which was able to differentiate c. psittaci from chlamydophila pecorum, c. pneumoniae, and ... | 2006 | 16282606 |
| chlamydia pneumoniae in foci of "early" calcification of the tunica media in arteriosclerotic arteries: an incidental presence? | only a few previous works investigated the involvement of chlamydia pneumoniae (chlamydophila pneumoniae) in arterial calcification. the present study investigated a possible association between c. pneumoniae and medial calcification. carotid artery segments obtained by endarterectomy from 60 patients were examined by pcr and immunohistochemistry to identify the presence of c. pneumoniae. arterial specimens showing double-positive (n = 17), double-negative (n = 22), and single-positive results ( ... | 2006 | 16272196 |
| comparison of intranasal and transcutaneous immunization for induction of protective immunity against chlamydia muridarum respiratory tract infection. | chlamydia pneumoniae causes a range of respiratory infections including bronchitis, pharyngitis and pneumonia. infection has also been implicated in exacerbation/initiation of asthma and chronic obstructive pulmonary disease (copd) and may play a role in atherosclerosis and alzheimer's disease. we have used a mouse model of chlamydia respiratory infection to determine the effectiveness of intranasal (in) and transcutaneous immunization (tci) to prevent chlamydia lung infection. female balb/c mic ... | 2006 | 16153755 |
| protective effects of simvastatin on coronary artery function in swine with acute infection. | the risk for coronary events may rise during acute infection. perturbation in coronary endothelial function emerges as one important link. we investigated whether simvastatin could protect the coronary arterial function from the adverse effects of acute infection in swine. | 2006 | 16223501 |
| aetiological role of viral and bacterial infections in acute adult lower respiratory tract infection (lrti) in primary care. | lower respiratory tract infections (lrti) are a common reason for consulting general practitioners (gps). in most cases the aetiology is unknown, yet most result in an antibiotic prescription. the aetiology of lrti was investigated in a prospective controlled study. | 2006 | 16227331 |
| chlamydia pneumoniae in an ex vivo human artery culture model. | the role of the obligate intracellular pathogen chlamydia pneumoniae in the development of atherosclerosis could not be completely clarified. reasons are the highly discrepant results obtained in the hitherto existing studies and the lack of an experimental system allowing the direct examination of chlamydial effects in the human vasculature. we established a human ex vivo organ culture model for the characterization of vascular chlamydial infection. ninety sections of renal arteries, obtained f ... | 2006 | 16202418 |
| detection of chlamydia pneumoniae and helicobacter pylori in atherosclerotic plaques of carotid artery by polymerase chain reaction. | a possible role of some microorganisms has been proposed in the pathogenesis of atherosclerosis, but it is still an unresolved issue. we investigated the presence of chlamydia pneumoniae and helicobacter pylori dna in carotid artery atherosclerotic plaques by using pcr. | 2006 | 16183317 |
| seropositivity to chlamydia pneumoniae or helicobacter pylori and coronary artery disease. | our aim was to investigate the relationship between the serologic status concerning chlamydia pneumoniae and helicobacter pylori with the presence of coronary artery disease (cad), which remain a controversial issue in literature. we studied 208 patients with cad and 94 controls with no evidence of obstructive cad; all of them angiographically confirmed. the seropositivity to c. pneumoniae was 91% in patients with cad vs 86% in controls (p>0.05). the h. pylori seroprevalence rates were 77% and 6 ... | 2006 | 15993502 |
| inhibitory effect of dietary phenolic compounds on chlamydia pneumoniae in cell cultures. | chlamydial infections are very common worldwide. all chlamydial species have a tendency to cause persistent infections, which have been associated to several chronic diseases including blinding trachoma, infertility and coronary heart disease (chd). at present, no efficient treatment for the eradication of chronic chlamydial infections exists and, thus, new antichlamydial compounds are urgently needed. this study was designed to screen antichlamydial activity of natural flavonoids and other natu ... | 2006 | 16414027 |
| chronic inflammation, immune response, and infection in abdominal aortic aneurysms. | abdominal aortic aneurysms (aaa) are associated with atherosclerosis, transmural degenerative processes, neovascularization, decrease in content of vascular smooth muscle cells, and a chronic infiltration, mainly located in the outer aortic wall. the chronic infiltration consists mainly of macrophages, lymphocytes, and plasma cells. the dominant cells are th2 restricted cd3+ lymphocytes expressing interleukine 4, 5, 8, and 10, and tumor necrosis factor-alpha for regulation of the local immune re ... | 2006 | 16414293 |
| inflammation and atherosclerosis. | purpose: the aim of this article is to discuss the role of inflammation in atherosclerosis. summary: an initial chemical, mechanical or immunological insult induces endothelial dysfunction. this triggers a cascade of inflammatory reactions, in which monocytes, macrophages, t lymphocytes and vascular smooth muscle cells participate. leukocyte adhesion molecules, cytokines, growth factors and metalloproteinases participate in all stages of atherogenesis. almost all of the traditional risk factors ... | 2006 | 16359887 |
| markers of inflammation and infection influence the outcome of patients with baseline asymptomatic carotid lesions: a 5-year follow-up study. | it is still in debate whether the evaluation of markers of infection and inflammation may be of importance for cerebrovascular and cardiovascular prevention, and we aimed to investigate this field in a prospective 5-year clinical follow-up study in patients with early stages of atherosclerosis. | 2006 | 16373649 |
| the influence of age and gender on the population-based incidence of community-acquired pneumonia caused by different microbial pathogens. | to determine the population-based incidence of community-acquired pneumonia (cap) in adults and to assess the relative importance of age and gender on the incidence of infections caused by different microbial pathogens. | 2006 | 16375972 |
| increased aortic intima-media thickness in 11-year-old healthy children with persistent chlamydia pneumoniae seropositivity. | the relationship between chlamydia pneumoniae (cpn) infection and arterial measures of preclinical atherosclerosis has remained controversial. because atherogenesis begins in early life, we examined whether carotid and aortic intima-media thickness (imt) and brachial artery endothelial function are associated with cpn seropositivity in children. | 2006 | 16397138 |
| lack of serum oligoclonal antibody responses to chlamydophila pneumoniae in multiple sclerosis. | 2006 | 16401902 | |
| antibiotic therapy for coronary heart disease: the myth and the reality. | atherosclerosis is acknowledged as an active inflammatory and thrombotic disease, as opposed to simple degeneration. infection with microorganisms may contribute to this inflammation and hence the atherosclerotic process. the "infective" hypothesis - first proposed more than a century ago by virchow - has been revisited in recent years and has implicated numerous microorganisms as potential stimuli. the greatest body of evidence points to chlamydia pneumoniae, a respiratory pathogen, as the "cul ... | 2006 | 16404482 |
| association between seroprevalence of anti-chlamydial antibodies and long-term cardiovascular mortality in chronic hemodialysis patients. | chlamydial infection has been suspected in the pathogenesis of ischemic heart disease. however, it remains undetermined if persistent chlamydial infection is related to cardiovascular mortality in regular hemodialysis (hd) patients. we measured chlamydia pneumoniae (cp) antibody seropositivity in 154 hd subjects (age 59 +/- 11 years, time on hd 13 +/- 7 years, male/female = 101/53), and prospectively examined an association between cp antibody status and cardiovascular death for 56 months of fol ... | 2006 | 16288759 |
| novel enzyme immunoassay utilizing lipopolysaccharide-binding protein as a capture molecule for the measurement of chlamydial lipopolysaccharide in serum. | chlamydia pneumoniae causes respiratory tract infections. it has a tendency to cause persistent infections, which have been associated with several chronic diseases (e.g., atherosclerosis). at present, there is no reliable method for the diagnosis of chronic c. pneumoniae infection. we developed a novel enzyme immunoassay (eia) for the quantification of chlamydial lipopolysaccharide (clps) in human serum. serum clps was solubilized with detergent and then captured by lps-binding protein (lbp). l ... | 2006 | 16290027 |
| chlamydia pneumoniae seropositivity in women with pre-eclampsia. | 2006 | 16298370 | |
| chlamydia pneumoniae: comparison with findings of mycoplasma pneumoniae and streptococcus pneumoniae at thin-section ct. | to retrospectively compare thin-section computed tomographic (ct) findings of chlamydia pneumoniae pneumonia with those of streptococcus pneumoniae pneumonia and mycoplasma pneumoniae pneumonia. | 2006 | 16304082 |
| chlamydia pneumoniae and mycoplasma pneumoniae pneumonia: comparison of clinical, epidemiological characteristics and laboratory profiles. | the purpose of our retrospective 3-year study was to analyse and compare clinical and epidemiological characteristics in hospitalized patients older than 6 years with community-acquired pneumonia (cap) caused by chlamydia pneumoniae (87 patients) and mycoplasma pneumoniae (147 patients). c. pneumoniae and m. pneumoniae infection was confirmed by serology. c. pneumoniae patients were older (42.12 vs. 24.64 years), and were less likely to have a cough, rhinitis, and hoarseness (p<0.001). c. pneumo ... | 2006 | 16316495 |
| chlamydia pneumoniae alters mildly oxidized low-density lipoprotein-induced cell death in human endothelial cells, leading to necrosis rather than apoptosis. | atherosclerosis is characterized by oxidative stress that induces lipid and protein oxidation in the vascular wall. oxidized low-density lipoproteins (oxldls) are present in lesions, and one of their actions is to induce apoptosis or necrosis in vascular cells. a role for chlamydia pneumoniae in atherosclerosis has been proposed, but the mechanisms involved remain largely unknown. | 2006 | 16323142 |
| is seropositivity enough to show the association between coronary artery disease and chlamydia pneumoniae and helicobacter pylori infection? | 2006 | 16325945 | |
| reliability of radiographic findings and the relation to etiologic agents in community-acquired pneumonia. | in a clinical setting the chest radiograph is the reference standard in establishing the diagnosis of community-acquired pneumonia (cap). this study aimed to assess interobserver reliability (ir) of radiographic findings and the relationship to different causative pathogens in cap. chest radiographs of 192 patients with pneumonia, obtained from a database, were reviewed by 2 radiologists and 1 respiratory physician without specific clinical information. main pattern of infiltrate, extent of pneu ... | 2006 | 16337367 |
| randomised placebo controlled multicentre trial to assess short term clarithromycin for patients with stable coronary heart disease: claricor trial. | to determine if the macrolide clarithromycin affects mortality and cardiovascular morbidity in patients with stable coronary heart disease. | 2006 | 16339220 |
| mechanisms of chlamydophila pneumoniae-mediated gm-csf release in human bronchial epithelial cells. | chlamydophila pneumoniae is an important respiratory pathogen. in this study we characterized c. pneumoniae strain tw183-mediated activation of human small airway epithelial cells (saec) and the bronchial epithelial cell line beas-2b and demonstrated time-dependent secretion of granulocyte macrophage colony-stimulating factor (gm-csf) upon stimulation. tw183 activated p38 mitogen-activated protein kinase (mapk) in epithelial cells. kinase inhibition by sb202190 blocked chlamydia-mediated gm-csf ... | 2006 | 16340003 |
| chronic chlamydia pneumoniae infection in patients with symptomatic atherothrombosis. | the aim of the present study was to search for an association between chronic chlamydia pneumoniae infection, indicated by elevated antibody titers against the pathogen, atherothrombosis and the occurrence of arterial ischemic events. | 2006 | 16352340 |
| antibiotics active against chlamydia do not reduce the risk of myocardial infarction. | there is evidence that chlamydia pneumoniae (cp) is involved in the aetiology of myocardial infarction (mi). randomised trials do not support a beneficial effect of antibiotics in secondary prevention of mi, but the evidence for an effect on primary prevention is conflicting. we investigated if past use of antibiotics active against cp is associated with a decreased risk of developing mi. | 2006 | 16331522 |
| [chlamydia pneumoniae infection and stroke]. | 2006 | 17461153 | |
| [chronic bacterial-and-viral vasculitis as a possible risk factor of disordered stability of the coronary atherosclerosis course]. | in order to assess the real significance of some plasma and vascular indices in disorders of the stable course of coronary heart disease (chd) in chronic bacterial- and viral infection-invasion, we determined the blood plasma lipid hydrogen peroxide (lhp) activity, a direct index of the lipid peroxidation degree, and measured the concentration of specific antibodies to chlamydia pneumoniae (c. pneunoniae), herpes simplex virus type 1 (hsv-1), cytomegalovirus (cmv) and epstein-barr virus (ebv) by ... | 2006 | 17641612 |
| [impact of chronic chlamydia pneumoniae infection on left ventricular remodeling after myocardial infarction]. | postmyocardial infarction left ventricular remodeling is modified by inflammatory processes and structural changes in the myocardium. chlamydia pneumoniae (chp) causes chronic myocyte infection, affects apoptosis and tnf-alpha production, and may induce cross reactivity with alpha myosin. this is the way in which this intracellular pathogen may modulate remodeling on the cellular and organ level. | 2006 | 17642135 |
| [chlamydia pneumoniae infections]. | chlamydia pneumoniae, an obligate intracellular human pathogen, causes infections of the respiratory tract. it is a significant cause of both lower and upper acute respiratory illnesses, including pneumonia, bronchitis, pharyngitis and sinusitis. most respiratory infections caused by c. pneumoniae are mild or asymptomatic. some studies have suggested a possible association of c. pneumoniae infection and acute exacerbations of asthma and chronic obstructive pulmonary disease (copd). seroepidemiol ... | 2006 | 17037392 |
| [treatment and course of community-acquired pneumonia caused by atypical pathogens]. | to study the course of disease and outcomes in a group of patients with community-acquired pneumonia caused by atypical pathogens (mycoplasma pneumoniae, legionella species ,coxiella burnetii, and chlamydophila pneumoniae) according to the empiric treatment received. | 2006 | 17040657 |
| [serologic diagnosis of chlamydial and mycoplasma pneumoniae infections]. | the diagnosis of chlamydia trachomatis infection can be based either on direct detection of the organism or its components or indirectly by measuring antibodies as markers of the individual's response to the infection. the latter is currently of limited value. neither igg or iga antibodies can be used to diagnose current genital infection by chlamydia trachomatis or to exclude such an infection. there is no solid ground as yet for the use of iga antibodies as a marker of persistant or unresolved ... | 2006 | 17040871 |
| influence of particle size on drug delivery to rat alveolar macrophages following pulmonary administration of ciprofloxacin incorporated into liposomes. | in order to confirm the efficacy of ciprofloxacin (cpfx) incorporated into liposomes (cpfx-liposomes) for treatment of respiratory intracellular parasite infections, the influence of particle size on drug delivery to rat alveolar macrophages (ams) following pulmonary administration of cpfx-liposomes was investigated. cpfx-liposomes were prepared with hydrogenated soybean phosphatidylcholine (hspc), cholesterol (ch) and dicetylphosphate (dcp) in a lipid molar ratio of 7/2/1 by the hydration metho ... | 2006 | 17043040 |
| aetiology and resistance patterns of community-acquired pneumonia in león, nicaragua. | we conducted a prevalence study to gain greater insight into the aetiology, bacterial resistance and risk factors for community-acquired pneumonia (cap) in the region of león, nicaragua. during the period from july 2002 to january 2005, all consecutive patients with signs and symptoms suggestive of cap were included in the study. sputum samples, paired serum samples and urinary samples were collected for the detection of respiratory pathogens. the most frequently identified pathogens were strept ... | 2006 | 17046211 |
| a study on immunopathogenetic mechanisms of atherosclerotic process caused by chronic infection of chlamydia pneumoniae in rats (ratus novergicus). | this study was aimed to determine the correlations between duration of chlamydia pneumoniae infection and the development of atherosclerotic process in white-rats' (ratus novergicus) aorta. | 2006 | 17132885 |
| molecular mimicry and horror autotoxicus: do chlamydial infections elicit autoimmunity? | all species of the order chlamydiales are obligate intracellular eubacterial pathogens of their various hosts. two chlamydial species, chlamydia trachomatis and chlamydia pneumoniae, are primarily human pathogens, and each is known to cause important diseases. some strains of c. trachomatis are sexually transmitted and frequently cause severe reproductive problems, primarily in women. other strains of the organism serve as the aetiological agents for blinding trachoma, still the leading cause of ... | 2006 | 17134529 |
| management of group a beta-hemolytic streptococcal pharyngotonsillitis in children. | acute pharyngotonsillitis is one of the most common infections encountered by pediatricians and family physicians. according to the us vital health statistics report, acute pharyngotonsillitis is responsible for more than 6 million office visits each year by children younger than 15 years of age and an additional 1.8 million visits by adolescents and young adults aged 15 to 24 years. most children with acute pharyngotonsillitis have symptoms that can be attributed to infection with a respiratory ... | 2006 | 17137534 |
| the association of metabolic syndrome and chlamydia pneumoniae, helicobacter pylori, cytomegalovirus, and herpes simplex virus type 1: the persian gulf healthy heart study. | the metabolic syndrome together with insulin resistance and their consequences are basic factors in pathogenesis of atherosclerosis. chronic infections with herpes simplex virus type 1 (hsv-1), cytomegalovirus (cmv), and chlamydia pneumoniae are associated with the development of atherosclerosis and coronary heart disease. the infectious aspects of metabolic syndrome have not been investigated. | 2006 | 17140429 |
| the association of carotid plaque inflammation and chlamydia pneumoniae infection with cerebrovascular symptomatology. | inflammation and infection have been implicated in the pathogenesis of carotid artery atherosclerosis, but their role in cerebrovascular disease symptomatology is not so well defined. we hypothesized that carotid disease symptomatology was associated with specific serologic markers of inflammation and chlamydia pneumoniae infection and the presence of the pathogen and concentration of tumor necrosis factor-alpha (tnf-alpha) on the atheroma. | 2006 | 17145421 |
| evaluation of serological tests detecting chlamydophila pneumoniae-specific immunoglobulin m antibody. | to evaluate a newly developed enzyme-linked immunosorbent assay (elisa) (hitazyme c. pneumoniae) detecting chlamydophila pneumoniae-specific immunoglobulin m (igm) antibody, we compared the assay with culturing, immunoblotting and the microimmunofluorescence (mif) test. | 2006 | 17106155 |
| interventional and medical treatment of acute heart failure due to inflammation: four cases. | four patients (aged 15-41 years, mean age 26.7 years) with fulminant myocarditis undergoing mechanical circulatory support are reported. all patients suffered from acute low-output syndrome refractory to inotropic support. diagnosis was confirmed by histology and immunohistochemistry. rt-pcr (reverse transcription-polymerase chain reaction) from endomyocardial biopsy specimens revealed parvovirus b19 in two patients and a coinfection with chlamydia pneumoniae and parvovirus b19 in one patient. m ... | 2006 | 17149677 |
| clarithromycin in coronary heart disease: excess mortality in the long term. | (1) based on an attractive hypothesis implicating inflammation caused by chlamydia pneumoniae in cardiovascular disease, several clinical trials have tested whether antibiotic therapy has a long-term preventive effect. (2) one trial showed an increase in mortality 3 years after a 2-week course of clarithromycin in patients with coronary heart disease (9.8% versus 7.8% in the placebo group). this difference resulted mainly from higher cardiovascular mortality (5.1% versus 3.5%). (3) a meta-analys ... | 2006 | 17167932 |
| association between eotaxin (ccl11), c-reactive protein, and antimicrobial antibodies in patients undergoing coronary angioplasty. | eotaxin (ccl11) is a potent chemoattractant for eosinophils and lymphocytes. apart from its functions in the eosinophilic system, eotaxin has been shown to be overexpressed in atherosclerosis. we therefore sought to determine whether chronic infection with chlamydia pneumoniae or other infectious agents is correlated with concentrations of eotaxin or c-reactive protein since this mechanism could explain the finding that chronic infection stimulates smooth muscle cell migration and plaque develop ... | 2006 | 17169268 |
| long-term antibiotic treatment with roxithromycin in patients with multiple sclerosis. | there are conflicting results concerning an association between chlamydia pneumoniae and ms (multiple sclerosis). in the present study, we investigated a possible therapeutic option with antibiotics. | 2006 | 17180590 |
| h pylori infection and systemic antibodies to caga and heat shock protein 60 in patients with coronary heart disease. | to determine the overall prevalence of h pylori and caga positive h pylori infection and the prevalence of other bacterial and viral causes of chronic infection in patients with coronary heart disease (chd), and the potential role of anti-heat-shock protein 60 (hsp60) antibody response to these proteins in increasing the risk of chd development. | 2006 | 17203526 |
| ubiquinone (coenzyme q) biosynthesis in chlamydophila pneumoniae ar39: identification of the ubid gene. | ubiquinone is an essential electron carrier in prokaryotes. ubiquinone biosynthesis involves at least nine reactions in escherichia coli. 3-octaprenyl-4-hydroxybenzoate decarboxylase (ubid) is an important enzyme on the pathway and deletion of the ubid gene in e. coli gives rise to ubiquinone deficiency in vivo. a protein from chlamydophila pneumoniae ar39 had significant similarity compared with protein ubid from e. coli. based on this information, the protein-encoding gene was used to swap its ... | 2006 | 17033719 |
| chronic chlamydia pneumoniae infection may promote coronary artery disease in humans through enhancing secretion of interleukin-4. | atherosclerosis is an inflammatory response, probably to a range of initiating causes. chronic infection with chlamydia pneumoniae (c.pn) has been suggested as one cause, but the nature of the association is controversial, in large part due to lack of an identified mechanism to link infection with the atherosclerotic process in man. this study examined 139 consecutive subjects with stable chest pain, with the aim of correlating the serological status of c.pn infection with the pattern of secreti ... | 2006 | 17034570 |
| chlamydophila pneumonia: specific mrna in aorta ascendens in patients undergoing coronary artery by-pass grafting. | the objective of this prospective study was to investigate if chlamydophila pneumoniae (cp)-specific dna and mrna are present in tissue samples from the wall of aorta ascendens in patients undergoing by-pass surgery for coronary artery disease (cad) that includes stable angina pectoris (sap, 25 patients) and acute coronary syndrome (acs, 19 patients). viable cp was detected in 8/44 (18%) patients using reversed transcriptase pcr (rt-pcr) against bacterial mrna with detection of cdna using real-t ... | 2006 | 16938728 |
| systemic and mucosal antibody response in experimental chlamydia pneumoniae infection of mice. | chlamydia pneumoniae is a common human respiratory pathogen, and sera from infected individuals recognize several proteins of c. pneumoniae. we produced c. pneumoniae-specific proteins in a bacillus subtilis expression system. we then used these recombinant c. pneumoniae proteins and purified c. pneumoniae elementary bodies as antigens in enzyme immunoassays to assess the kinetics and protein specificity of the systemic and mucosal antibody responses induced by c. pneumoniae intranasal infection ... | 2006 | 16941954 |
| [simultaneous detection by multiplex pcr of atypical bacterial pathogens involved in infections of respiratory tract. is it useful for the microbiological diagnosis of respiratory infections]. | the aim was to evaluate the "strategical place" of the new commercial test chlamylege (argene-biosoft-france) which allows the simultaneous detection in respiratory samples of chlamydophila pneumoniae, mycoplasma pneumoniae and most legionella species using a pcr multiplex. 41 patients with an atypical pneumonia were included, all standard procedures of diagnosis were done and in addition the chamylege test. a pathogen was identified in 12 patients, an other microorganisms than the 3 targeted by ... | 2006 | 17027196 |
| chlamydophila (chlamydia) pneumoniae infection of human astrocytes and microglia in culture displays an active, rather than a persistent, phenotype. | the intracellular pathogen chlamydia pneumoniae can cause persistent infections during which its morphologic, molecular, and pathogenic characteristics differ importantly from those of active infection. this bacterium was identified within astrocytes and microglia in the brain of late-onset alzheimer disease patients. we investigated whether infection of these two host cell types displays an active or persistent growth phenotype. | 2006 | 17031241 |
| chronic fatigue syndrome. | chronic fatigue syndrome (cfs) is thought to have a worldwide prevalence of 0.4-1% with approximately 240,000 patients in the uk. diagnosis is based on clinical criteria and critically depends on exclusion of other physical and psychiatric diseases. studies of pathogenesis have revealed immune system abnormalities and chronic immune activation, dysfunction of the hypothalamic-pituitary-adrenal (hpa) axis, brain abnormalities, evidence of emotional stress (comprising host aspects) and evidence of ... | 2006 | 16978917 |
| infectious agents, inflammation, and growth factors: how do they interact in the progression or stabilization of mild human atherosclerotic lesions? | advanced complicated atherosclerotic lesions have been related to many factors, including inflammation, infectious agents, and growth factors. mycoplasma pneumoniae (mp) and chlamydia pneumoniae (cp), inflammation, and growth factors have been associated with severe atherosclerotic lesions in necropsy material in recent work at our lab. the present study intends to clarify the pathogenesis of atherosclerosis, analyzing which of these elements (macrophages, mp, cp, lymphocytes, and growth factors ... | 2006 | 16983590 |
| nf-kappab and inhibitor of apoptosis proteins are required for apoptosis resistance of epithelial cells persistently infected with chlamydophila pneumoniae. | infection with chlamydophila pneumoniae (cpn) renders host cells resistant to apoptosis induced by a variety of stimuli. while modulation of apoptosis has been extensively studied in cells acutely infected with cpn, very little is known on how persistent chlamydial infection influences host cell survival. here we show that epithelial cells persistently infected with cpn resist apoptosis induced with tnfalpha or staurosporine. cpn induced the activation of nuclear factor kappa b (nf-kappab) and i ... | 2006 | 16984419 |
| initial empiric antimicrobial treatment of chlamydia pneumoniae: a study of 54 cases in the republic of macedonia. | analysis of the adequacy of the initial empiric antimicrobial treatment of patients with acute chlamydia pneumoniae (cp) infection, admitted to the infectious diseases clinic, clinical centre, medical faculty, skopje, republic of macedonia, for community-acquired pneumonia. | 2006 | 16985483 |
| infectious causes of multiple sclerosis. | 2006 | 16987736 | |
| involvement of tnfalpha -308a promoter polymorphism in the development of asthma in children infected with chlamydophila pneumoniae. | several data indicate a connection between chlamydophila pneumoniae infection and asthma. although c. pneumoniae is a common cause of infection, not all infected patients develop asthma. this suggests that certain individuals may be genetically predisposed to the chronic effects of c. pneumoniae infection on airway functions. we investigated the possible modifying effect of different polymorphisms on c. pneumoniae infection and on the susceptibility to asthma in 318 children, among those 144 had ... | 2006 | 16988194 |
| multiple sclerosis: an infectious syndrome involving chlamydophila pneumoniae. | the concept of autoimmune myelinopathy as the primary pathology in multiple sclerosis (ms) is problematic. vasculitis is seen in the ms brain, both within lesions and in adjacent normal-appearing white matter. the first observation in acute relapse is the sudden, orderly death of oligodendrocytes; inflammatory removal of unsupported myelin seems to be a secondary process. an alternative explanation for these findings is that oligodendrocyte infection might trigger an inflammatory response. many ... | 2006 | 16996738 |
| interaction between chlamydia pneumoniae seropositivity, inflammation and risk factors for atherosclerosis in patients with severe coronary stenosis. | to investigate whether chlamydia pneumoniae (cpn) seropositivity in patients with suspected coronary artery disease (cad) (n = 81) is associated with increases in markers of inflammation, the severity of coronary atherosclerosis, and traditional risk factors for cardiovascular events. | 2006 | 17000560 |
| chlamydia and mycoplasma serology in respiratory tract infections of children. | one of the challenges in planning the treatment of respiratory tract infection in children is identifying the causative agent. the objective of the present study was to investigate the incidence of mycoplasma and chlamydia in the etiology of respiratory tract infections of children. the present study included 100 children, three months to 12 years of age, admitted to the outpatient department of pediatrics with such respiratory symptoms as fever, cough and respiratory distress. following a detai ... | 2006 | 17001543 |
| effect of pex, a noncatalytic metalloproteinase fragment with integrin-binding activity, on experimental chlamydophila pneumoniae infection. | chlamydophila pneumoniae is a pathogen that is involved in acute and chronic respiratory infections and that is associated with asthma and coronary artery diseases. in this study, we evaluated the effects of pex, a noncatalytic metalloproteinase fragment with integrin-binding activity, against experimental infections caused by c. pneumoniae. moreover, we investigated the relationships between c. pneumoniae and alpha(v)beta(3) integrin functions in order to explain the possible mechanism of actio ... | 2006 | 17005805 |
| arterial stiffness and chlamydia pneumoniae infection in coronary artery disease. is there a link? | we investigated the possible association between antichlamydial antibodies and pulse wave analysis (pwa) parameters in a cohort of patients with coronary artery disease (cad). | 2006 | 17012139 |
| automated identification of multiple micro-organisms from resequencing dna microarrays. | there is an increasing recognition that detailed nucleic acid sequence information will be useful and even required in the diagnosis, treatment and surveillance of many significant pathogens. because generating detailed information about pathogens leads to significantly larger amounts of data, it is necessary to develop automated analysis methods to reduce analysis time and to standardize identification criteria. this is especially important for multiple pathogen assays designed to reduce assay ... | 2006 | 17012284 |
| chlamydophila (chlamydia) pneumoniae in the alzheimer's brain. | we assessed the presence and characteristics of the intracellular pathogen chlamydophila (chlamydia) pneumoniae in brain-tissue samples from 25 patients with late-onset alzheimer's disease (ad) and 27 non-ad control individuals. 20/27 ad patients, but only 3/27 controls, were pcr-positive in multiple assays targetting the cpn1046 and cpn0695 genes. culture of the organism from brain-tissue homogenate from one ad patient, and assessment of various chlamydial transcripts in rna preparations from s ... | 2006 | 17052268 |
| serology of chlamydia pneumoniae in patients with chronic cough. | chronic cough is one of the more common respiratory symptoms. controversy exists as to whether chlamydia infection is associated with chronic cough. as such, the association of chronic cough with serological evidence of chlamydia pneumoniae (c. p) infection and a systemic inflammatory marker was assessed. | 2006 | 17052312 |