Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| infective endocarditis caused by anaerobic bacteria. | this review summarizes the microbiology, diagnosis and management of infective endocarditis (ie) due to anaerobic bacteria. anaerobic bacteria are an uncommon but important cause of ie. most cases are caused by the anaerobic and microaerophilic streptococci propionibacterium acnes, bacteroides fragilis and clostridium species. predisposing factors and signs and symptoms of ie caused by anaerobic bacteria are similar to those seen in ie due to facultative anaerobic bacteria with the following exc ... | 2008 | 19056073 |
| when a commensal becomes a pathogen. | 2008 | 19070255 | |
| quantitative analysis of propionibacterial dna in bronchoalveolar lavage cells from patients with sarcoidosis. | the causes of sarcoidosis are still unknown. propionibacterial subspieces are thought to be one of the most likely sources of antigens. here we attempted to measure the amount of propionibacterial dna in bronchoalveolar lavage (bal) cell samples from patients with sarcoidosis and other pulmonary diseases. | 2008 | 19070256 |
| [infectious osteoarthritis due to propionibacterium acnes]. | 2008 | 19087834 | |
| benzoyl peroxide cleansers for the treatment of acne vulgaris: status report on available data. | benzoyl peroxide (bpo) cleansers are commonly prescribed for treatment of acne vulgaris. in fact, they represent approximately half of all bpo prescriptions from dermatology practices. data are limited on the ability of bpo cleansers to reduce counts of propionibacterium acnes, impact on reduction and emergence of antibiotic-resistant p acnes strains, and efficacy for facial and truncal acne vulgaris. this article discusses available data on bpo cleanser formulations. | 2008 | 19090337 |
| significance of propionibacterium acnes-positive samples in spinal instrumentation. | a retrospective study about propionibacterium acnes infections after cotrel-dubousset (cd) instrumentation. | 2008 | 19092607 |
| antimicrobial susceptibilities of propionibacterium acnes isolated from patients with acne vulgaris. | antibiotic susceptibilities of propionibacterium acnes in japan were determined. erythromycin-resistance was found in 10.4% (5/48) of the strains, and four of these were cross-resistance to clindamycin. although the erythromycin ribosome methylase gene erm(x) was looked for, no strain carrying erm(x) was found. sequencing analysis revealed that all of the erythromycin-resistant strains had a mutation in the peptidyl transferase region of the 23s rrna gene: g2057a, a2058g, or a2059g. consequently ... | 2008 | 19120976 |
| sterility screening of platelet concentrates: questioning the optimal test strategy. | routine bacterial monitoring of apheresis platelet concentrates (apc) and pooled platelet concentrates (ppc) was introduced in two german blood services using culture and real-time reverse transcriptase (rt)-polymerase chain reaction (pcr). the results of testing are reviewed and used to discuss different strategies for detection of bacterial contamination of pcs. | 2008 | 19121182 |
| the effect of propionibacterium acnes on maturation of dendritic cells derived from acne patients' peripherial blood mononuclear cells. | propionibacterium acnes (p. acnes) has been implicated in the pathogenesis of acne vulgaris which is the most common cutaneous disorder. it has a proinflammatory activity and takes part in immune reactions modulating the th1/th2 cellular response. the exposure of dendritic cells (dcs) to whole bacteria, their components, cytokines or other inflammatory stimuli and infectious agents induces differentiation from immature dcs into antigen-presenting mature dcs. the aim of the study was to evaluate ... | 2008 | 19141410 |
| antibiotic-resistant propionibacterium acnes suppressed by a benzoyl peroxide cleanser 6%. | adding topical benzoyl peroxide (bpo) to antibiotics can reduce resistant propionibacterium acnes in patients with acne receiving antibiotic therapy. benzoyl peroxide often is formulated as a wash, but no published data exist regarding bpo wash formulation efficacy in reducing resistant strains of p acnes. this 3-week, open-label, single-center study evaluated the effects of bpo cleanser 6% on antibiotic-resistant p acnes populations. the study involved 30 healthy adults who were free of acne bu ... | 2008 | 19181031 |
| functions of c2d macrophage cells after adoptive transfer. | macrophage function depends on their in situ location. to test this hypothesis, we examined functional changes of the c2d macrophage cell line after adoptive transfer. in vitro, c2d macrophages reside early in the macrophage lineage and show little functional activity. after in vivo i.p. culture, c2d macrophage cells switch their cytokine/chemokine profile from primarily th2 cytokines produced in vitro to a th1 profile including mip-1alpha, il-6, and tnf-alpha. the in vivo environment also cause ... | 2008 | 18063699 |
| optimization of electrotransformation conditions for propionibacterium acnes. | propionibacterium acnes has been known to be involved in the pathology of acne. however, the definite mechanism in the development of acne and the inflammation are unknown. for p. acnes, a transformation method has not been established, although it is believed to be a basic tool for gene manipulation. this study attempted to develop a p. acnes transformation method by using electroporation. various parameters were used to develop and optimize the transformation of p. acnes. among them two factor ... | 2008 | 18077027 |
| microbial colonization of an in vitro model of a tissue engineered human skin equivalent--a novel approach. | this was a preliminary investigation to define the conditions of colonization of a human skin equivalent (se) model with cutaneous microorganisms. ses of 24 mm diameter were constructed with a dermal matrix of fibrin containing fibroblasts and a stratified epidermis. microbial colonization of the ses was carried out in a dry environment, comparable to 'in vivo' skin, using a blotting technique to remove inoculation fluid. the microbial communities were sampled by scrub washing and viable cells e ... | 2008 | 18081841 |
| propionibacterium acnes lacks the capability to proliferate in platelet concentrates. | propionibacterium acnes is considered to be one of the most frequent contaminants of platelet concentrates (pcs) when anaerobic culture-based detection methods are used. but propionibacteria are often detected too late when blood products have already been transfused. therefore, its transfusion relevance is still demanding clarification because studies of the outcome of patients transfused with p. acnes-contaminated pcs are still uncommon. in this study, we monitored clinical effects in patients ... | 2008 | 18086288 |
| comparison of multiple methods for quantification of microbial biofilms grown in microtiter plates. | in the present study six assays for the quantification of biofilms formed in 96-well microtiter plates were optimised and evaluated: the crystal violet (cv) assay, the syto9 assay, the fluorescein diacetate (fda) assay, the resazurin assay, the xtt assay and the dimethyl methylene blue (dmmb) assay. pseudomonas aeruginosa, burkholderia cenocepacia, staphylococcus aureus, propionibacterium acnes and candida albicans were used as test organisms. in general, these assays showed a broad applicabilit ... | 2008 | 18155789 |
| propionibacterium acnes in granulomas of a patient with necrotising sarcoid granulomatosis. | 2008 | 18156583 | |
| immunization with the cysteine proteinase ldccys1 gene from leishmania (leishmania) chagasi and the recombinant ldccys1 protein elicits protective immune responses in a murine model of visceral leishmaniasis. | the gene ldccys1 encoding a cysteine proteinase of 30 kda from leishmania (leishmania) chagasi, as well as the recombinant cysteine proteinase rldccys1, obtained by cloning and expression of the ldccys1 gene in the phis vector, were used to evaluate their ability to induce immune protective responses in balb/c mice against l. (l.) chagasi infection. mice were immunized subcutaneously with rldccys1 plus bacille calmette guerin (bcg) or propionibacterium acnes as adjuvants or intramuscularly with ... | 2008 | 18160187 |
| a molecular analysis of prokaryotic and viral dna sequences in prostate tissue from patients with prostate cancer indicates the presence of multiple and diverse microorganisms. | inflammation, both acute and chronic, is a common feature of prostate histology. while inflammation has been proposed to play an important role in both benign and malignant growth of the prostate, the stimuli for this inflammation remain poorly characterized. infectious pathogens are potential stimuli for prostatic inflammation. | 2008 | 18163428 |
| babesia: the protective effects of killed propionibacterium acnes on the infections of two rodent babesia parasites in mice. | in the present study, we investigated the protective effects of killed propionibacterium acnes on the infections of two rodent babesia parasites in mice. pre-treatment with "eqstim" (a commercially available immunostimulant containing killed p. acnes) showed significant resistance to both infections. to elucidate the immunological status in the mice, the concentrations of multiple cytokines were measured in serum collected from infected mice. after b. microti infection, the levels of interleukin ... | 2008 | 18164706 |
| interleukin-12 regulates natural killer cell-dependent propionibacterium acnes-primed, lipopolysaccharide-induced liver injury. | aim: interleukin (il)-12, produced primarily by macrophage/monocytes, modulates mature t and natural killer (nk) cell functions, including cytotoxicity and cytokine production. methods: to determine the role of il-12 in propionibacterium acnes (p. acnes)-primed, lipopolysaccharide (lps)-induced liver injury, mice were injected with an anti-il-12 monoclonal antibody (mab) 1 and 2 days before p. acnes injection (day 0) or 5 and 6 days before lps challenge (day 7). the survival rates, plasma cytoki ... | 2008 | 18197879 |
| propionibacterium acnes: a rare cause of late prosthetic valve endocarditis and aortic root abscess. | propionibacterium acnes is an anaerobic, non-spore forming, gram-positive bacillus, and is often part of the normal flora of human skin. it usually has relatively low virulence. however, it can rarely cause serious infections including infections of prosthetic valves, native valves, and annuloplasty rings. we describe a rare case of late prosthetic aortic valve endocarditis and aortic root abscess caused by p. acnes, an easily ignored pathogen. | 2008 | 18199505 |
| sebocytes express functional cathelicidin antimicrobial peptides and can act to kill propionibacterium acnes. | 2008 | 18200058 | |
| a new phylogenetic group of propionibacterium acnes. | immunofluorescence microscopy-based identification of presumptive propionibacterium acnes isolates, using the p. acnes-specific mab qubpa3, revealed five organisms with an atypical cellular morphology. unlike the coryneform morphology seen with p. acnes types i and ii, these isolates exhibited long slender filaments (which formed large tangled aggregates) not previously described in p. acnes. no reaction with mabs that label p. acnes types ia (qubpa1) and ii (qubpa2) was observed. nucleotide seq ... | 2008 | 18201989 |
| [inducible histamine protects mice from hepatitis through h2-receptor stimulation]. | histamine is well known for its roles in allergic diseases and anaphylaxis through h(1)-receptor stimulation. the h(1)-receptor stimulation by histamine results in an increase in vascular permeability, vasodilatation, and stimulation of nerve terminals in primary sensory neurons, thereby accelerating the inflammatory responses. on the other hand, histamine has been demonstrated to be involved in the regulation of innate and acquired immune responses through h(2)-receptors. in a previous study wi ... | 2008 | 18239372 |
| chemical composition and biological activities of essential oils extracted from korean endemic citrus species. | the aim of this study was to analyze the chemical composition of 14 kinds of citrus oils and to test their biological activities. citrus essential oils were obtained by steam distillation from immature fruits collected from jeju island and were analyzed using gas chromatograph (gc)- flame ionization detectors (fid) and gc-ms. limonene (55.4% to 91.7%), myrcene (2.1% to 32.1%), alpha-pinene (0.6% to 1.6%) and linalool (0.4% to 6.9%) were the major components in most citrus species. to evaluate in ... | 2008 | 18239420 |
| early bacterial keratitis after presbyopic lasik. | to report an unusual case of infectious keratitis that occurred after presbyopic laser-assisted in situ keratomileusis (lasik). | 2008 | 18245979 |
| vaccination targeting a surface sialidase of p. acnes: implication for new treatment of acne vulgaris. | acne vulgaris afflicts more than fifty million people in the united state and the severity of this disorder is associated with the immune response to propionibacterium acnes (p. acnes). systemic therapies for acne target p. acnes using antibiotics, or target the follicle with retinoids such as isotretinoin. the latter systemic treatment is highly effective but also carries a risk of side effects including immune imbalance, hyperlipidemia, and teratogenicity. despite substantial research into pot ... | 2008 | 18253498 |
| ultrastructural findings in progressive macular hypomelanosis indicate decreased melanin production. | the pathogenesis of progressive macular hypomelanosis (pmh) is unknown. recently, westerhof et al. (arch dermatol 2004; 140: 210-214) hypothesized that propionibacterium acnes produces a depigmenting factor that interferes with melanogenesis in the skin, resulting in hypopigmented spots. the purpose of the study is to gain an insight into the pathogenesis of pmh. | 2008 | 18266692 |
| skin microbiota: a source of disease or defence? | microbes found on the skin are usually regarded as pathogens, potential pathogens or innocuous symbiotic organisms. advances in microbiology and immunology are revising our understanding of the molecular mechanisms of microbial virulence and the specific events involved in the host-microbe interaction. current data contradict some historical classifications of cutaneous microbiota and suggest that these organisms may protect the host, defining them not as simple symbiotic microbes but rather as ... | 2008 | 18275522 |
| n-substituted 3-acetyltetramic acid derivatives as antibacterial agents. | in order to expand the structure-activity relationship of tetramic acid molecules with structural similarity to the antibiotic reutericyclin, 22 compounds were synthesized and tested against a panel of clinically relevant bacteria. key structural changes on the tetramic acid core affected antibacterial activity. various compounds in the n-alkyl 3-acetyltetramic acid series exhibited good activity against gram-positive bacterial pathogens including bacillus anthracis, propionibacterium acnes, ent ... | 2008 | 18281930 |
| revision shoulder arthroplasty for glenoid component loosening. | although glenoid component loosening has been recognized as a common reason for failure after total shoulder arthroplasty, there are few studies on the outcome of revision surgery for this problem. the purpose of this study is to determine the outcome of patients who underwent revision for glenoid component loosening. between 1976 and 2002, 68 shoulders in 66 patients underwent revision for glenoid loosening at our institution. group i consisted of 33 shoulders that underwent placement of a new ... | 2008 | 18282720 |
| a peptide with a progln c terminus in the human saliva peptidome exerts bactericidal activity against propionibacterium acnes. | nine proline-rich peptides ending with a proline-glutamine c terminus in a salivary peptidome were sequenced by matrix-assisted laser desorption ionization time of flight time of flight tandem mass spectrometry. a gpppqggrpq peptide binds gram-positive propionibacterium acnes and considerably inhibits bacterial growth. the peptide exhibiting innate immunity may be applied for treatment of various p. acnes-associated human diseases. | 2008 | 18285475 |
| ascending aortic pseudoaneurysm: a late complication of coronary artery bypass. | 2008 | 18292416 | |
| direct aspiration of capsular bag material in a case of sequestered endophthalmitis. | chronic recurrent endophthalmitis can occur following uncomplicated cataract surgery with intraocular lens implantation secondary to organisms sequestered in the capsular bag. there is a need to identify these sequestered organisms to facilitate appropriate management. frequently, specimens from the anterior chamber and vitreous cavity could be unyielding, especially in the early cases in which the vitreous is still uninvolved. this article highlights the technique of directly sampling the capsu ... | 2008 | 18292631 |
| infection after the surgical treatment of adolescent idiopathic scoliosis: evaluation of the diagnosis, treatment, and impact on clinical outcomes. | retrospective case-control. | 2008 | 18303461 |
| a young man with propionibacterium acnes-induced shunt nephritis. | 2008 | 18322539 | |
| [granulomatous diseases and pathogenic microorganism]. | granuloma formation is a chronic inflammatory reaction where macrophage system and other inflammatory cells are involved. after some antigen exposure and processing, t cells, macrophages, epithelioid cells, and giant cell are activated, and granulomas are formed. granuloma is considered as a defense mechanism against antigens, which stay in the organs without inactivation. granulomas including fibroblasts extra-cellular matrix surround and isolate the antigens. granulomas are classified to nonin ... | 2008 | 18326339 |
| the ectopeptidases dipeptidyl peptidase iv (dp iv) and aminopeptidase n (apn) and their related enzymes as possible targets in the treatment of skin diseases. | skin cells express dipeptidyl peptidase iv (dp iv) and aminopeptidase n (apn) and their related molecules of the dp iv-like family dp2, dp6, dp8, dp9 and fibroblast activation protein (fap), as well as the cytoplasmic alanyl aminopeptidase (caap). the inhibitors of dp iv-like activity, lys(z(no2))-thiazolidide (lznt) and lys(z(no2))-pyrrolidide (lznp), and the apn inhibitors actinonin and bestatin affect proliferation, differentiation and cytokine production in sebocytes and keratinocytes, which ... | 2008 | 17981718 |
| photopneumatic technology for the treatment of acne vulgaris. | treatment of acne vulgaris with light sources necessitates multiple targets including propionibacterium acnes and sebaceous glands. traditional light sources such as blue light capitalize on p acnes bacteria as targets while infrared lasers and radiofrequency devices target the sebaceous gland. a novel device combining vacuum and a unique broadband light source was designed to combine multiple targets for the effective treatment of acne. the objective of this study was to demonstrate the safety ... | 2008 | 18335650 |
| propionibacterium acnes is a common colonizer of intravascular catheters. | propionibacterium spp. are common flora of human skin. nevertheless, currently recommended culture procedures do not include anaerobic processing with the result that this organism may go undetected on a colonized catheter. to determine the rate of catheter colonization by propionibacterium spp., a sample of 1000 vascular catheters was processed by the roll-plate technique and, after conventional aerobic processing, all primary culture plates were reincubated in an anaerobic atmosphere. propioni ... | 2008 | 18336916 |
| overview of acne and its treatment. | acne affects more than 85% of teenagers in the united states and often continues into adulthood. the most deleterious form can result in permanent scarring on the face, chest, and back. although the pathogenic features of acne are well known, the initiating factor remains unknown. isotretinoin is effective against all of the pathogenic features of acne but is contraindicated in pregnant women and has been associated with elevations in triglyceride levels. combination regimens appear to be effect ... | 2008 | 18338651 |
| treatment of primary isolated shoulder sepsis in the adult patient. | isolated shoulder sepsis is an uncommon clinical problem with little information in the literature on causative organisms and potential sequelae. we examined the organisms involved, surgical treatments, antibiotic treatments rendered, and complications in these cases. we retrospectively reviewed the records of 19 adult patients (19 shoulders) who underwent operative treatment of isolated shoulder sepsis from 1996 to 2005. patient age, gender, laboratory studies, previous treatment, surgical proc ... | 2008 | 18347887 |
| dendritic cell expression of the notch ligand jagged2 is not essential for th2 response induction in vivo. | we have addressed the hypothesis that notch ligands play a decisive role in determining the ability of antigen-presenting cells to influence t cell polarization. dendritic cells displayed distinct expression profiles of delta and jagged ligands for notch when exposed to biologically relevant pathogen preparations associated with th1 or th2 responses. expression of delta4 was increased, and jagged2 decreased, after dendritic cell exposure to the th1-promoting bacterium propionibacterium acnes. in ... | 2008 | 18350543 |
| cd209(+) macrophages mediate host defense against propionibacterium acnes. | propionibacterium acnes is a major etiological factor of acne, triggering an inflammatory response in part through the activation of tlr2. in this study, we demonstrate that activation of peripheral blood monocytes with p. acnes in vitro induced their differentiation into two distinct innate immune cell subsets, cd209(+) macrophages and cd1b(+) dendritic cells. furthermore, p. acnes induced expression of mrna for the cytokines il-15 and gm-csf, which differentiate cd209(+) and cd1b(+) cells, res ... | 2008 | 18354216 |
| fluoroquinolone-resistant bacteria and methicillin-resistant staphylococci from normal preoperative conjunctiva. | 2008 | 18362000 | |
| cerebrospinal fluid eosinophilia in children with ventricular shunts. | eosinophils have been reported in children with cerebrospinal fluid (csf) shunts. the goal of this study was to describe the risk factors, relationship to infection, and clinical significance of csf eosinophilia in a large group of shunt-treated patients. | 2008 | 18377304 |
| resistance determinant erm(x) is borne by transposon tn5432 in bifidobacterium thermophilum and bifidobacterium animalis subsp. lactis. | the erm(x) gene from erythromycin- and clindamycin-resistant bifidobacterium strains was characterised by polymerase chain reaction and sequence analysis, including flanking regions. results suggest that the resistance determinant was part of transposon tn5432 that has been described in several opportunistic pathogens such as corynebacterium striatum and propionibacterium acnes. | 2008 | 18378122 |
| [infection of cerebrospinal fluid shunt systems]. | cerebrospinal fluid (csf) shunt infection is a cause of considerable morbidity and mortality. shunt infection is produced mainly during surgery and by surgical wound infection. staphylococcus spp. (> 50% methicillin-resistant) are the most common causative bacteria, although gram-negative bacilli (10%-25%) and propionibacterium acnes are becoming increasingly implicated. shunt malfunction syndrome and fever are the most frequent clinical manifestations, whereas signs of meningeal irritation are ... | 2008 | 18381044 |
| salivary microbiota of hiv-positive children and its correlation with hiv status, oral diseases, and total secretory iga. | this study aimed to investigate the prevalence and levels of salivary microorganisms in hiv-positive children, and their correlation to hiv status, oral lesions, and salivary iga levels. | 2008 | 18384349 |
| microbiology and management of joint and bone infections due to anaerobic bacteria. | to describes the microbiology, diagnosis, and management of septic arthritis and osteomyelitis due to anaerobic bacteria. | 2008 | 18392922 |
| emerging topical antimicrobial options for mild-to-moderate acne: a review of the clinical evidence. | topical antimicrobial agents are commonly used as first-line agents for the management of mild to moderate acne vulgaris. agents with antibacterial activity (eg, benzoyl peroxide and clindamycin), reduce counts of propionibacterium acnes, while also decreasing the numbers of inflammatory and noninflammatory lesions. in order to optimize efficacy, topical antibiotics are most commonly used in combination with benzoyl peroxide, an approach which also reduces the emergence of strains of p acnes tha ... | 2008 | 18404864 |
| new developments in topical antimicrobial therapy for acne. | benzoyl peroxide (bpo) has been an important component of the acne treatment armamentarium for decades. a number of characteristics contribute to its success in acne, including its lipophilicity, potent antibacterial activity, and ability to suppress antibiotic-resistant strains of propionibacterium acnes. with some commercially available products in which bpo comprises crystals in suspension, aggregation of bpo can occur on the skin surface in large clumps, resulting in poor penetration of seba ... | 2008 | 18404865 |
| anti-acne activity of selaginella involvens extract and its non-antibiotic antimicrobial potential on propionibacterium acnes. | acne is a typical condition of adolescence and is caused by multi-factorial events including hormonal, microbiological and immunological mechanisms. although there has been much debate about the direct involvement of bacteria, propionibacterium acnes is now believed to contribute to the inflammatory stages of the condition, and thus initiate the inflamed lesion. the present study examined the anti-acne properties of the selaginella involvens extract (sie) in cell models. primarily, sie was not f ... | 2008 | 17926337 |
| pathological findings in the lens capsules and intraocular lens in chronic pseudophakic endophthalmitis: an electron microscopy study. | the aim of this study was to describe the pathological findings in lens capsules and intraocular lens (iol) studied by scanning and/or transmission electron microscopy (sem and tem, respectively) in a series of four eyes with chronic pseudophakic endophthalmitis (cpe). | 2008 | 17041575 |
| the antibody response to propionibacterium acnes is an independent predictor of serum prostate-specific antigen levels in biopsy-negative men. | to investigate whether the serum titres of propionibacterium acnes antibodies in patients undergoing prostate biopsy are associated with prostate cancer or markers of prostate disease, including serum prostate-specific antigen (psa) levels. | 2008 | 17850358 |
| biofilm formation of the pathogens of fatal bacterial granuloma after trauma: potential mechanism underlying the failure of traditional antibiotic treatments. | the pathogen of a new type of disease - fatal bacterial granuloma after trauma (fbgt) - was found to be propionibacterium acnes (p. acnes). although in vitro studies showed that the pathogenic p. acnes are sensitive to conventional antibiotics, treatments of fbgt patients with these antibiotics were ineffective. the underlying mechanisms were not clear. since p. acnes are able to form biofilm on orthopaedic biomaterials in vitro, and pathogenic p. acnes of acnes vulgaris was known to form biofil ... | 2008 | 17852906 |
| anti-inflammatory activity of sertaconazole nitrate is mediated via activation of a p38-cox-2-pge2 pathway. | sertaconazole nitrate is an antifungal agent that exhibits anti-inflammatory activity; however, the mechanism for this action was unknown. we investigated the cellular mechanisms by which sertaconazole exerts its anti-inflammatory activity in keratinocytes and human peripheral blood mononuclear cells (pbmcs). paradoxically, sertaconazole was found to activate the proinflammatory p38 mitogen-activated protein kinase. treatment with sertaconazole also resulted in the induction of cyclooxygenase-2 ... | 2008 | 17637821 |
| the evolution of benzoyl peroxide therapy. | since its first use in dermatology last century, benzoyl peroxide (bpo) has undergone a number of reformulations, each enhancing its efficacy, tolerability, or both. benzoyl peroxide can be used as monotherapy or in combination with oral or topical antibiotics or topical retinoids. its antimicrobial activity is based on the generation of highly reactive oxygen radicals, a physicochemical effect to which propionibacterium acnes has not developed resistance. in addition to its nonspecific antimicr ... | 2008 | 19202772 |
| selection of therapy for acne vulgaris: balancing concerns about antibiotic resistance. | the widespread use of long-term antibiotics to treat acne and rosacea has resulted in increased propionibacterium acnes resistance to antibiotics. although resistance may decrease treatment effectiveness in some cases, it also is clear that antimicrobial activity is not the only role antibiotics play in acne management. the anti-inflammatory activity of antibiotics contributes to antipropionibacterial efficacy. in addition, the use of benzoyl peroxide (bpo) in combination with antibiotics to red ... | 2008 | 19202773 |
| cloning and expression of antibacterial goat lactoferricin from escherichia coli ad494(de3)plyss expression system. | goat lactoferricin (glfcin), an antibacterial peptide, is released from the n terminus of goat lactoferrin by pepsin digestion. two glfcin-related cdnas, glfcin l and glfcin s, encoding ala20-ser60 and ser36-ser60 of goat lactoferrin, respectively, were cloned into the pet-23a(+) expression vector upstream from (his)6-tag gene and transformed into escherichia coli ad494(de3)plyss expression host. after being induced by isopropyl-beta-d-thiogalactopyranoside (iptg), two (his)6-tag fused recombina ... | 2008 | 19244908 |
| proteomics integrated with escherichia coli vector-based vaccines and antigen microarrays reveals the immunogenicity of a surface sialidase-like protein of propionibacterium acnes. | proteomics is a powerful tool for the identification of proteins, which provides a basis for rational vaccine design. however, it is still a highly technical and time-consuming task to examine a protein's immunogenicity utilizing traditional approaches. here, we present a platform for effectively evaluating protein immunogenicity and antibody detection. a tetanus toxin c fragment (tet-c) was used as a representative antigen to establish this platform. a cell wall-anchoring sialidase-like protein ... | 2008 | 21136919 |
| what is the role of benzoyl peroxide cleansers in acne management?: do they decrease propionibacterium acnes counts? do they reduce acne lesions? | 2008 | 21218192 | |
| sapho syndrome: is a range of pathogen-associated rheumatic diseases extended? | sapho syndrome, representing a constellation of synovitis, acne, palmo-plantar pustulosis, hyperostosis, and osteitis, is now recognized as a distinct medical entity: a reactive infectious osteitis. genetic, immunological, and bacterial mechanisms are implicated in the development of the disease. diagnostic problems may arise due to non-complete manifestations of sapho: either acne and arthritis or acne and anterior wall osteitis with an unclear pustulosis history. the interventional study of as ... | 2009 | 19895718 |
| susceptibility comparisons of normal preoperative conjunctival bacteria to fluoroquinolones. | to compare the susceptibility and efficacy of 3 fluoroquinolones, (levofloxacin, gatifloxacin, and moxifloxacin) in treating conjunctival bacteria in patients having ocular surgery. | 2009 | 19251140 |
| microbiologic diagnosis of prosthetic shoulder infection by use of implant sonication. | we recently described a sonication technique for the diagnosis of prosthetic knee and hip infections. we compared periprosthetic tissue culture to implant sonication followed by sonicate fluid culture for the diagnosis of prosthetic shoulder infection. one hundred thirty-six patients undergoing arthroplasty revision or resection were studied; 33 had definite prosthetic shoulder infections and 2 had probable prosthetic shoulder infections. sonicate fluid culture was more sensitive than periprosth ... | 2009 | 19261785 |
| chemical composition and biological activities of jeju thymus quinquecostatus essential oils against propionibacterium species inducing acne. | 2009 | 19282635 | |
| involvement of propionibacterium acnes in the augmentation of lipogenesis in hamster sebaceous glands in vivo and in vitro. | propionibacterium acnes is considered to be involved in the aggravation of acne vulgaris, but it remains unclear whether p. acnes directly influences lipogenesis in sebaceous glands. in this study, we showed that a culture medium of p. acnes (acnes-cm) and formalin-killed p. acnes (f-acnes) prepared from p. acnes strains, jcm6473 and jcm6425, intracellularly augmented lipid droplet formation and triacylglycerol (tg) synthesis in undifferentiated and insulin-differentiated hamster sebocytes. acne ... | 2009 | 19282842 |
| isolation of propionibacterium acnes from a case of placentitis and abortion in a cow. | on the basis of the scarcity of reports in the veterinary literature, it appears that propionibacterium spp. are rarely associated with disease or isolated from cattle tissues. recently, propionibacterium spp. has been associated with multifocal abscessation in cattle. this report describes a case of necrosuppurative placentitis and abortion in an adult holstein cow. numerous colonies of small, pleomorphic, gram-positive, rod-shaped bacteria were observed within the fibrin lattice associated wit ... | 2009 | 19286514 |
| 4-1bb functions as a survival factor in dendritic cells. | 4-1bb (cd137) is expressed on dendritic cells (dcs) and its biological function has remained largely unresolved. by comparing 4-1bb-intact (4-1bb(+/+)) and 4-1bb-deficient (4-1bb(-/-)) dcs, we found that 4-1bb was strongly induced on dcs during the maturation and that dc maturation was normal in the absence of 4-1bb. however, dc survival rate was low in the absence of 4-1bb, which was due to the decreased bcl-2 and bcl-x(l) in 4-1bb(-/-) dcs compared with 4-1bb(+/+) dcs after dc maturation. cons ... | 2009 | 19299708 |
| acute-onset nosocomial endophthalmitis after cataract surgery: incidence, clinical features, causative organisms, and visual outcomes. | to estimate the incidence of acute-onset endophthalmitis after cataract surgery and to report its clinical features, microbiology, and final visual outcomes. | 2009 | 19304084 |
| sonication of removed breast implants for improved detection of subclinical infection. | capsular fibrosis is a severe complication after breast implantation with an uncertain etiology. microbial colonization of the prosthesis is hypothesized as a possible reason for the low-grade infection and subsequent capsular fibrosis. current diagnostic tests consist of intraoperative swabs and tissue biopsies. sonication of removed implants may improve the diagnosis of implant infection by detachment of biofilms from the implant surface. | 2009 | 19322605 |
| the novel anti-propionibacterium acnes compound, sargafuran, found in the marine brown alga sargassum macrocarpum. | we screened extracts of 342 species of marine algae collected from japanese coastlines for antibacterial activity against propionibacterium acnes, and found a novel antibacterial compound, which we named sargafuran, from the meoh extract of the marine brown alga, sargassum macrocarpum. sargafuran has low cytotoxicity, and the mic against p. acnes was 15 microg ml(-1), showing a broad antibacterial activity against gram-positive bacteria. a time-kill study showed that sargafuran was bactericidal ... | 2009 | 19329987 |
| effects of propionibacterium acnes on various mrna expression levels in normal human epidermal keratinocytes in vitro. | propionibacterium acnes is one of the most significant pathogenic factors of acne vulgaris. this bacteria relates to acne by various pathways. it has also been reported that p. acnes influences pro-inflammatory cytokine production in keratinocytes in vitro. however, the influence on the differentiation of keratinocytes by p. acnes has not been studied extensively. we analyzed the expression of keratinocyte differentiation-specific markers, keratins, and pro-inflammatory cytokines in normal human ... | 2009 | 19348660 |
| abies koreana essential oil inhibits drug-resistant skin pathogen growth and lps-induced inflammatory effects of murine macrophage. | since acne vulgaris is the combined result of a bacterial infection and the inflammatory response to that infection, we examined whether abies koreana essential oil (ake) possessed anti-inflammatory and antibacterial activities against skin pathogens. in this study, ake showed excellent antibacterial activities against drug-susceptible and -resistant propionibacterium acnes and staphylococcus epidermidis, which are acne-causing bacteria. in addition, ake reduced the lps-induced secretion of tumo ... | 2009 | 19350303 |
| purulent pericarditis: report of 2 cases and review of the literature. | purulent pericarditis, a localized infection within the pericardial space, has become a rare entity in the modern antibiotic era. although historically a disease of children and young adults, this is no longer the case: the median age at the time of diagnosis has increased by nearly 30 years over the past 6 decades. despite advances in diagnostic and treatment modalities, purulent pericarditis remains a life-threatening illness. unfortunately, the diagnosis is made postmortem in more than half t ... | 2009 | 19352300 |
| propionibacterium acnes colonization of the human shoulder. | propionibacterium acnes (p. acnes) is frequently cultured in patients with wound infections after shoulder surgery. the purpose of this study was to characterize the colonization of various anatomic locations with p. acnes in order to explain this clinical observation. | 2009 | 19362854 |
| changing the face of acne therapy. | many innovations in acne therapy have evolved since the discovery in 1949 that vitamin a derivatives affected epidermal proliferation. approval of topical tretinoin solution in 1971 was followed by modifications in the formulation to improve tolerability and provide flexibility in dosing. identification of retinoid receptors led to research that resulted in 2 receptor-selective synthetic retinoids: adapalene and tazarotene. today, topical retinoids are one of the cornerstones of acne therapy and ... | 2009 | 19363873 |
| increased interferon-gamma, interleukin-12p40 and il-8 production in propionibacterium acnes-treated peripheral blood mononuclear cells from patient with acne vulgaris: host response but not bacterial species is the determinant factor of the disease. | acne vulgaris is a multifactorial inflammatory disease of the sebaceous follicles of the face and torso that frequently occurs in adolescence. initially, acne starts as a non-inflammatory comedo. subsequently, inflammatory reactions evolve to pustules, granulomas and cystic lesions. many pathogenic mechanisms have been proposed including sebum excretion, obstruction of hair follicles, impaired keratinization of hair epithelium, bacterial overgrowth and immunological mechanisms; the role of propi ... | 2009 | 19375895 |
| antimicrobial property of lauric acid against propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris. | the strong bactericidal properties of lauric acid (c12:0), a middle chain-free fatty acid commonly found in natural products, have been shown in a number of studies. however, it has not been demonstrated whether lauric acid can be used for acne treatment as a natural antibiotic against propionibacterium acnes (p. acnes), which promotes follicular inflammation (inflammatory acne). this study evaluated the antimicrobial property of lauric acid against p. acnes both in vitro and in vivo. incubation ... | 2009 | 19387482 |
| biofilm formation by propionibacterium acnes is a characteristic of invasive isolates. | propionibacterium acnes is a common and probably underestimated cause of delayed joint prosthesis infection. bacterial biofilm formation is central in the pathogenesis of infections related to foreign material, and p. acnes has been shown to form biofilm both in vitro and in vivo. here, biofilm formation by 93 p. acnes isolates, either from invasive infections (n = 45) or from the skin of healthy people (n = 48), was analysed. the majority of isolates from deep infections produced biofilm in a m ... | 2009 | 19392888 |
| suture-related corneal infections after clear corneal cataract surgery. | three patients at our institution developed corneal infections associated with sutures placed after clear corneal incision cataract surgery. the time to infection was 9 weeks, 22 months, and 33 months. one patient required injection of intravitreal antibiotic agents for presumed endophthalmitis associated with the corneal infection. two patients were treated with topical fortified antibiotic eyedrops only. although there was no significant change in visual acuity after resolution of the infectio ... | 2009 | 19393897 |
| sonication is superior to scraping for retrieval of bacteria in biofilm on titanium and steel surfaces in vitro. | low-virulence implant infections are characterized by bacterial colonization of the implant with subsequent biofilm formation. in these cases, soft tissue biopsies often prove to be culture negative. consequently, detachment of the causative adherent bacteria is crucial for correct microbiological diagnosis. using an in vitro model, we compared 4 methods of biofilm sampling from metal surfaces. | 2009 | 19404811 |
| anti-acne activities of pulsaquinone, hydropulsaquinone, and structurally related 1, 4-quinone derivatives. | quinone type compound, pulsaquinone 1, isolated from the aqueous ethanol extract of the roots of pulsatilla koreana exhibited antimicrobial activities against an anaerobic non-spore-forming gram-positive bacillus, propionibacterium acnes, which is related with the pathogenesis of the inflamed lesions in a common skin disease, acne vulgaris. compound 1 was unstable on standing and thus converted to more stable compound 2, namely hydropulsaquinone by hydrogenation, whose activity was comparable to ... | 2009 | 19407964 |
| [post-surgery cerebral abscess due to propionibacterium acnes]. | brain abscesses by propioni-bacterium acnes are rare. the rapid identification of this pathogen is important in order to choice the appropriate antibiotic therapy. we describe the case of a patient with excision of a multiform glioblastoma who 9 months later presented a tumor recurrence. a subtotal tumor excision was made and implants chemotherapy were placed in the residual tumor. after one month of surgery the patient presented a brain abscess. a craniotomy for drainage was performed. p. acnes ... | 2009 | 19414301 |
| protective effects of radix rosa laevigata against propionibacterium acnes and lipopolysaccharide-induced liver injury. | we investigated the effects of an extract of radix rosa laevigata (r. r. laevigata) on propionibacterium acnes (p. acnes) and lipopolysaccharide (lps)-induced acute liver injury. the plasma alanine aminotransferase (alt) activity was significantly elevated by an intravenous injection of heat-killed p. acnes at a dose of 0.4 mg/mouse and then with lps at 0.1 microg/mouse after 5 d. however, the elevated alt activity was significantly reduced by the administered of r. r. laevigata (125 and 500 mg/ ... | 2009 | 19420718 |
| primary chronic osteomyelitis of the jaw--a microbial investigation using cultivation and dna analysis: a pilot study. | the aims of this study were to investigate the infectious etiology of primary chronic osteomyelitis (pco) of the jaw using an extraoral sampling approach and molecular methods. | 2009 | 19426919 |
| effects of pithecellobium clypearia benth extract and its main components on inflammation and allergy. | the ethanol extract of pithecellobium clypearia benth (pce) was characterized to be rich in polyphenols by hplc analysis, and investigated for its anti-inflammatory and anti-allergic activities. in our assay, pce showed anti-inflammatory activity in both acute and auto-immune inflammation animal models. administration of pce can effectively inhibit the croton oil-induced ear edema and capillary permeability, the carrageenin-induced paw edema, and the liver injury caused by propionibacterium acne ... | 2009 | 19427894 |
| positive culture rate in revision shoulder arthroplasty. | we recognized a trend of positive cultures taken from presumably uninfected shoulders during revision arthroplasty. owing to the indolent nature of common shoulder pathogens such as propionibacterium acnes, these cultures often become positive several days, even weeks, after surgery. having concern regarding the potential importance of these positive cultures, we reviewed our revision arthroplasty population to determine the rate of positive intraoperative cultures in patients presumed to be ase ... | 2009 | 19434469 |
| novel mechanism of c-reactive protein for enhancing mouse liver innate immunity. | although c-reactive protein (crp) is a representative acute-phase protein produced by hepatocytes, the role of crp in liver innate immunity remains unclear. using c57bl/6 mice, the present study investigated how crp affects the functions of liver macrophages, kupffer cells, and natural killer / natural killer t (nk/nkt) cells under various conditions, including escherichia coli infection, septic shock, and multiorgan dysfunction induced by interleukin (il)-12/lipopolysaccharide (lps) (generalize ... | 2009 | 19444871 |
| [isolation, identification and rumen fermentation characteristics of propionibacterium acnes]. | characteristic of energy metabolism in ruminant is a negative energy balance in perinatal period. propionic acid from ruminal microbe fermentation is a vital glyconeogenesis substrate for preventing negative energy balance. we isolated and screened a propionibacterium acnes strain from health cow rumen fluid, and studied its rumen fermentation characteristics. | 2009 | 19445170 |
| propionibacterium skull osteomyelitis treated with daptomycin. | propionibacterium acnes (p. acnes) is emerging as a pathogen in postneurosurgical infections. a case of cranial bone flap infection due to p. acnes successfully treated with daptomycin is presented. this case demonstrates the potential of daptomycin as an option in the treatment of p. acnes. | 2009 | 19450922 |
| propionibacterium acnes endocarditis of a prosthetic aortic valve. | in the few reported cases of propionibacterium infective endocarditis involving prosthetic aortic valves, abscess is common and frequently requires surgery. we report a case of p. acnes infective endocarditis identified on prolonged blood cultures with aortic root abscess involving a starr-edwards valve. intravenous antibiotics and valve replacement led to recovery. | 2009 | 19455672 |
| in vitro activities of three synthetic peptides derived from epinecidin-1 and an anti-lipopolysaccharide factor against propionibacterium acnes, candida albicans, and trichomonas vaginalis. | the synthetic epinecidin-1(22-42) peptide was derived from positions 22-42 of epinephelus coioides epinecidin-1. the synthetic salf(55-76) cyclic peptide (cssalf(55-76)) and salf(55-76) linear peptide (lssalf(55-76)) contained sequences from positions 55 to 76 of the penaeus monodon anti-lipopolysaccharide factor (alf), respectively. we studied the in vitro activities of epinecidin-1(22-42), cssalf(55-76), and lssalf(55-76) against propionibacterium acnes, candida albicans, and trichomonas vagin ... | 2009 | 19463737 |
| cryptomeria japonica essential oil inhibits the growth of drug-resistant skin pathogens and lps-induced nitric oxide and pro-inflammatory cytokine production. | in this study, the chemical composition of cryptomeria japonica essential oil (cje) was analyzed and its biological activities were tested. cje was obtained by steam distillation from leaves collected from jeju island and analyzed by gas chromatography (gc)-flame ionization detection (fid) and gc-ms. kaurene (17.20%), elemol (10.88%), gamma-eudesmol (9.41%), and sabinene (8.86%) were the major components in cje. the antibacterial and anti-inflammatory activities of cje against drug-susceptible a ... | 2009 | 19469288 |
| screening of platelet concentrates for bacterial contamination: spectrum of bacteria detected, proportionof transfused units, and clinical follow-up. | screening of platelet concentrates (pcs) for bacterial contamination with cultivation methods is carried out as a routine procedure in some countries. the aim is to prevent the transfusion of contaminated pcs. the german evaluation of regular monitoring study group conducted a prospective multicenter study on 52,243 pcs to investigate the prevalence of bacteria (bact/alert, biomerieux). this study describes the detected bacterial spectrum, the proportion of pcs with a positive test result that h ... | 2009 | 19484239 |
| sterilization of platelet concentrates at production scale by irradiation with short-wave ultraviolet light. | bacterial contamination of platelet concentrates (pcs) is recognized as a serious threat to transfusion safety. we developed a simple method for sterilization of pcs with short-wave ultraviolet light (uvc). the effects of treatment on the sterility of contaminated pcs and in vitro platelet (plt) variables were evaluated. | 2009 | 19497057 |
| frequency of bacterial contamination of platelet concentrates before and after introduction of diversion method in japan. | bacterial contamination of platelet concentrates (pcs) is the major infectious risk in transfusion medicine. to evaluate the necessity of implementing novel strategies for the reduction of bacterial contamination, it is necessary to establish a precise contamination frequency in pcs. | 2009 | 19500321 |
| vaccination of dogs with six different candidate leishmaniasis vaccines composed of a chimerical recombinant protein containing ribosomal and histone protein epitopes in combination with different adjuvants. | chimerical protein "q", composed of antigenic ribosomal and histone sequences, in combination with live bcg is a promising canine leishmaniasis vaccine candidate; one of the few vaccine candidates that have been tested successfully in dogs. unfortunately, live bcg is not an appropriate adjuvant for commercial application due to safety problems in dogs. in order to find a safe adjuvant with similar efficacy to live bcg, muramyl dipeptide, aluminium hydroxide, matrix c and killed propionibacterium ... | 2009 | 19500553 |
| contribution of tir domain-containing adapter inducing ifn-beta-mediated il-18 release to lps-induced liver injury in mice. | after treatment with heat-killed propionibacterium acnes mice show dense hepatic granuloma formation. such mice develop liver injury in an interleukin (il)-18-dependent manner after challenge with a sublethal dose lps. as previously shown, lps-stimulated kupffer cells secrete il-18 depending on caspase-1 and toll-like receptor (tlr)-4 but independently of its signal adaptor myeloid differentiation factor 88 (myd88), suggesting importance of another signal adaptor tir domain-containing adapter in ... | 2009 | 19501931 |
| species of propionibacterium and propionibacterium acnes phylotypes associated with orthopedic implants. | propionibacterium sp. is commonly isolated in association with orthopedic implants, either as a pathogen or a colonizer. microbial characteristics that indicate whether the isolated species is a likely cause of orthopedic implant infection versus a colonizing agent would be clinically useful. we performed a prospective trial to determine the species of propionibacterium and the phylotype (ia, ib, ii, iii) of propionibacterium acnes isolated from the surface of removed orthopedic implants, and we ... | 2009 | 19505429 |