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[university clinics: yesterday, today, tomorrow]. 20083832205
accommodative hysteresis: influence on closed loop measures of far point and near point.the study examined accommodative hysteresis under closed loop viewing conditions. after sustained focus for 8 min at either the far-point (fp) or near-point (np) of accommodation, subjects exhibited hysteresis-like shifts in tonic accommodation, ie, dark focus (df), in the direction of the fixation target. measurement of np and fp before and after the focusing period showed that only the position of the np was significantly influenced, in a direction matching that of the df. the np shifted outwa ...20083610542
[photocoagulation with krypton laser of subretinal vessels in macular degeneration related to age. long-term results (apropos of 100 cases)]. 20082440603
short-term structured treatment for avoidant personality disorder.forty-two men and 34 women (mean age 27.5 years) who met dsm-iii criteria for avoidant personality disorder were randomly assigned to 1 of 3 treatment conditions or to a waiting-list control group. treatment ss who participated in a 10-week group treatment program displayed significantly greater improvement on a variety of self-report and behavioral measures than did untreated control subjects. the inclusion of skills-training procedures did not contribute to the effects of graduated exposure pr ...20082600246
critical care medicine: activities, advances, and implications for infection control. 20082271151
structural aspects of pathology in alzheimer's disease.the characteristic lesions of alzheimer's disease, neurofibrillary tangles and neuritic plaques, are the sites of accumulation of abnormal fibrillar material. the structure of the paired helical filament from tangles has been analysed by electron microscopy and biochemical studies have shown that it contains microtubule associated protein tau as a component. fibrils of beta-amyloid in the neuritic plaque arise by polymerization of a small proteolytic fragment of a much larger precursor protein. ...20082268679
tongue flaps in repair of large palatal defects.anteriorly based dorsal tongue flaps were used in 19 cleft patients for closing large palatal defects. the procedure was successful in 17 patients. one patient had partial marginal necrosis after division of the pedicle, while another had complete necrosis of the distal part of the flap. our results support the view that for success of the procedure, adequate length, width and thickness of the flap are important, while the height of the palate also plays a role.20082509583
polysplenia in a fetus with bradycardia from 26 to 36 weeks' gestation, complex cardiac malformations, and heart block.polysplenia is one of several splenic anomalies. frequently, as in the case presented here, significant cardiac anomalies coexist. these cardiac malformations determine the clinical course. in this case, early death was expected and occurred. this patient is different from others described in the literature in that persistent fetal bradycardia was noted at 26 weeks' gestation.20082276938
all blood, no stool: enterohemorrhagic escherichia coli o157:h7 infection.enterohemorrhagic escherichia coli serotype o157:h7 is a pathotype of diarrheagenic e. coli that produces one or more shiga toxins, forms a characteristic histopathology described as attaching and effacing lesions, and possesses the large virulence plasmid po157. the bacterium is recognized worldwide, especially in developed countries, as an emerging food-borne bacterial pathogen, which causes disease in humans and in some animals. healthy cattle are the principal and natural reservoir of e. col ...200818716441
priming of cd4+ t cells with porin of shigella dysenteriae activates the cells toward type 1 polarization.macrophages treated with porin of shigella dysenteriae were potent stimulators of naive t(h) cells since the porin-pulsed macrophages strongly proliferated the t cells and up-regulated the activation molecules cd69 and cd25 on cd4(+) t cells in allogeneic mixed leukocyte reaction. immunization of c57bl/6 mice with porin selectively induced the intracellular expression and release of ifn-gamma and had no effect on il-4 expression. in parallel to the predominant release of the t(h)1 cytokine ifn-g ...200818003602
shiga toxin 1 induces apoptosis through the endoplasmic reticulum stress response in human monocytic cells.shiga toxins (stxs) expressed by the enteric pathogens shigella dysenteriae 1 and enterohaemorrhagic escherichia coli are potent protein synthesis inhibitors. shiga toxins have also been shown to induce apoptosis in epithelial, endothelial and monocytic cells. the precise relationship between protein synthesis inhibition and induction of apoptosis is not known. we show that stimulation of the myelogenous leukaemia cell line thp-1 with purified stx1 induced the endoplasmic reticulum (er) stress r ...200818005243
differential expression of ompc and ompf in multidrug-resistant shigella dysenteriae and shigella flexneri by aqueous extract of aegle marmelos, altering its susceptibility toward beta-lactam antibiotics.steadily increasing resistance among shigella to beta-lactams, aminoglycosides, and tetracycline has compromised the utility of these commonly used antimicrobial agents. also, undesirable side effects of certain antibiotics have triggered immense interest in search of alternative therapies using medicinal plants. one such medicinal plant used since ancient times to cure diarrhea is aegle marmelos. the present study exemplifies the susceptibility of beta-lactam-resistant shigella dysenteriae and ...200818358664
[antigenic polysaccharides of bacteria: 40. the structures of o-specific polysaccharides from shigella dysenteriae types 3 and 9 and s. boydii type 4 revised by nmr spectroscopy].the reported structures of o-specific polysaccharides from three standard strains of shigella bacteria were corrected by modern nmr techniques. the revisions concerned the configuration of the o-glycoside linkage (s. dysenteriae type 3, structure 1), the positions of monosaccharide residue glycosylation and acetylation by pyruvic acid (s. dysenteriae type 9, structure 2), and the attachment position of the side monosaccharide chain (s. boydii type 4, structure 3) [struxture in text].200818365747
shigellosis: the current status of vaccine development.shigellosis, a major form of bacillary dysentery, is caused by infection with shigella organisms. in poor countries, shigella-caused dysentery is endemic and causes an estimated 163 million illness episodes annually and more than one million deaths. although several strategies have been used to develop vaccines targeting shigellosis, none has been licensed for use outside china. owing to the wide range of shigella serotypes and subtypes, there is a need for a multivalent vaccine representing pre ...200818448978
safety and immunogenicity of wrsd1, a live attenuated shigella dysenteriae type 1 vaccine candidate.among shigella serotypes shigella dysenteriae type 1 produces the most severe disease, including cases of hemolytic-uremic syndrome and pandemic outbreaks. wrsd1 is a live s. dysenteriae 1 strain attenuated by deletion of the virg(icsa) gene, which encodes a protein that mediates intercellular spread, and stxa and stxb, which encode the shiga toxin. in this phase i trial five groups of eight subjects ingested escalating doses of wrsd1 ranging from 10(3) to 10(7)cfu. no subject experienced fever ...200818468742
enterohaemorrhagic escherichia coli and shigella dysenteriae type 1-induced haemolytic uraemic syndrome.haemolytic uraemic syndrome (hus) can be classified according to the aetiology of the different disorders from which it is composed. the most prevalent form is that induced by shigatoxin producing escherichia coli (stec) and, in some tropical regions, by shigella dysenteriae type 1. stec cause a zoonosis, are widely distributed in nature, enter the food chain in different ways, and show regional differences. not all stec are human pathogens. enterohaemorrhagic e. coli usually cause attachment an ...200818493800
molecular characterization of multidrug-resistant shigella species isolated from epidemic and endemic cases of shigellosis in india.shigella species represent one of the growing numbers of antimicrobial-resistant bacteria in developing countries. fluoroquinolone-resistant strains of shigella dysenteriae type 1 and shigella flexneri type 2a emerged in india during 2002 and 2003, respectively. sixty strains of shigella from different parts of india were analysed for antimicrobial susceptibility, the presence of the qnr plasmid, mutations in the quinolone resistance determining regions (qrdrs), fluoroquinolone accumulation, and ...200818566144
porin-incorporated liposome induces toll-like receptors 2- and 6-dependent maturation and type 1 response of dendritic cell.porin of shigella dysenteriae was incorporated in liposome (pil) and presented to mouse splenic dendritic cells (dc). pil up-regulated toll-like receptor (tlr) 2 and tlr6 on dc, showing that co-expression of the two tlrs is involved in recognition of porin. detection of myeloid differentiating factor 88 (myd88)-tlr2 complex confirmed interaction between the two for triggering the downstream signaling, which ultimately led to tlr2-dependent nuclear translocation of nuclear factor-kappa b. pil-ind ...200818931363
occurrence and characteristics of the cytolysin a gene in shigella strains and other members of the family enterobacteriaceae.cytolysin a (clya, hlye, shea) is a hemolytic pore-forming toxin found in escherichia coli and salmonella enterica serovars typhi and paratyphi a. in the present study, analysis of several shigella strains revealed that they harbor only nonfunctional clya gene copies that have been inactivated either by the integration of insertion sequence (is) elements (shigella dysenteriae, shigella boydii, and shigella sonnei strains) or by a frameshift mutation (shigella flexneri). shigella dysenteriae and ...200818754791
gateways to clinical trials.11d10, 9vpnc-mncc; adalimumab, adefovir dipivoxil, alefacept, aln-rsv01, ame-133, amg-317, aminolevulinic acid methyl ester, amlodipine besylate/atorvastatin calcium, anisodamine, anti-il-5 receptor antibody, apremilast, aripiprazole, atacicept, atazanavir sulfate, atrasentan; banoxantrone, bevacizumab, bibw-2992, binodenoson, bms-387032; cac10, caldaret hydrate, cd-np, ceftobiprole medocaril, celivarone fumarate, certolizumab pegol, cholesteryl hydrophobized polysaccharide-her2 protein complex, ...200818773127
microcalorimetric studies of the action on four organic acids in radix isatidis on the growth of microorganisms.the actions of four organic acids in radix isatidis, a traditional chinese medicinal (tcm) herb, on escherichia coli, staphylococcus aureus and shigella dysenteriae growth were investigated by microcalorimetry. the four organic acids were syringic acid, 2-amino-benzoic acid, salicylic acid and benzoic acid. the power-time curves of escherichia coli, staphylococcus aureus and shigella dysenteriae growth with and without organic acids were acquired, meanwhile the extent and duration of inhibitory ...200818616177
functional characterization of the shigella dysenteriae heme abc transporter.the heme atp binding cassette (abc) transporter, shuuv, of shigella dysenteriae has been incorporated into proteoliposomes. functional characterization of shuuv revealed that atp hydrolysis and transport of heme from the periplasmic binding protein, shut, to the cytoplasmic binding protein, shus, are coupled. site-directed mutagenesis of shut residues proposed to be required for stabilization of the complex abolished heme transport. furthermore, residues his-252 and his-262, located in the trans ...200818616281
[detection of enteric pathogenic bacteria from surface waters by quantitative polymerase chain reaction (qpcr)].a rapid quantitative polymerase chain reaction (qpcr) analysis method with universal primers was developed to detect cell densities of the enteric pathogenic bacteria from 5 surface water of xi'an city for 4 months continuously. and the detection results by qpcr method were compared with counts of coliforms colony-forming units (cfu) determined by membrane filter (mf) analysis. the results showed that qpcr method had an estimated 94% confidence, and detection limit was 2.7 escherichia coli cells ...200818624175
haemolytic uraemic syndrome in children admitted to a rural district hospital in kenya.we studied children admitted to kilifi district hospital, kenya, between 1997 and 2005 with haemolytic uraemic syndrome (hus) and reviewed their records in order to determine the clinical features and outcomes of the disease. thirty-one children fulfilled the criteria: 21 (68%) had diarrhoea-associated hus (d + hus), the remainder did not (d-hus); five had involvement of the central nervous system. those with d-hus had lower haemoglobin and platelet counts when compared with those with d + hus. ...200818628547
the interplay between entamoeba and enteropathogenic bacteria modulates epithelial cell damage.mixed intestinal infections with entamoeba histolytica, entamoeba dispar and bacteria with exacerbated manifestations of disease are common in regions where amoebiasis is endemic. however, amoeba-bacteria interactions remain largely unexamined.200818648517
antimicrobial resistance in shigella species isolated in dakar, senegal (2004-2006).from may 2004 to october 2006, a prospective study was carried out in dakar, senegal, to update information about the antimicrobial susceptibility of shigella spp. isolated from stool specimens. among the 165 non-duplicate strains collected, 81 (49%) were identified as shigella flexneri, 75 (45%) as shigella sonnei, 5 (3%) as shigella boydii, and 4 (2%) as shigella dysenteriae. disk diffusion testing revealed that the majority of isolates were resistant to sulphonamides, trimethoprim-sulfamethox ...200818653976
[antigenic polysaccharides of bacteria: 41. structures of the o-specific polysaccharides of shigella dysenteriae types 4 and 5 revised by nmr spectroscopy].the earlier established structures of the acidic o-specific polysaccharides from two typical strains of the shigella dysenteriae bacterium were revised using modern nmr spectroscopy techniques. in particular, the configurations of the glycosidic linkages of glcnac (s. dysenteriae type 4) and mannose (s. dysenteriae type 5) residues were corrected. in addition, the location of the sites of nonstoichiometric o-acetylation in s. dysenteriae type 4 was determined: the lateral fucose residue was show ...200818695724
retrograde traffic in the biosynthetic-secretory route.in the biosynthetic-secretory route from the rough endoplasmic reticulum, across the pre-golgi intermediate compartments, the golgi apparatus stacks, trans golgi network, and post-golgi organelles, anterograde transport is accompanied and counterbalanced by retrograde traffic of both membranes and contents. in the physiologic dynamics of cells, retrograde flow is necessary for retrieval of molecules that escaped from their compartments of function, for keeping the compartments' balances, and mai ...200818270728
distribution and antibiotic susceptibility of shigella isolates in bangui, central african republic.we conducted a prospective study in four urban health care centres between january 2004 and november 2005 to determine the distribution and susceptibility patterns of shigella strains causing invasive diarrhoea in bangui, central african republic. of the 155 shigella isolated, shigella flexneri (51%) and shigella dysenteriae (30%) were the most common and the most resistant to usual antibiotics, including amoxicillin, sulphamethoxazole-trimethoprim and chloramphenicol. though multi-drug resistan ...200818282240
diverse antimicrobial killing by enterococcus faecium e 50-52 bacteriocin.an effective bacteriocin was identified and characterized. lactic acid bacteria were screened against campylobacter jejuni. one bacteriocin producer, enterococcus faecium (nrrl b-30746), was studied. the isolate was grown, and the bacteriocin was purified to single-band homogeneity. biochemical traits indicated that the peptide was a class iia bacteriocin, and it was named e 50-52. the bacteriocin had a molecular weight of 3339.7 and an isoelectric point of 8.0. the minimal inhibitory concentrat ...200818293921
the o-polysaccharide of escherichia coli o112ac has the same structure as that of shigella dysenteriae type 2 but is devoid of o-acetylation: a revision of the s. dysenteriae type 2 o-polysaccharide structure.the o-antigen structure of shigella dysenteriae type 2 was reinvestigated using chemical modifications along with high-resolution 2d (1)h and (13)c nmr spectroscopy. the o-antigen was found to contain a pyruvic acid acetal, which was overlooked in an early study, and the following revised structure of the pentasaccharide repeating unit was established: where approximately 70% glcnac residues bear an o-acetyl group at position 3. the o-antigen of escherichia coli o112ac was found to have the same ...200818308298
phase 1 clinical trial of live attenuated shigella dysenteriae type-1 deltaicsa deltaent deltafep deltastxa:hgr oral vaccine sc599 in healthy human adult volunteers.twenty-eight adults received between 10(2) and 10(8)colony forming units of live shigella dysenteriae type-1 vaccine sc599, attenuated by deletion of invasion (icsa), iron chelation (ent, fep) and shiga toxin a-subunit (stxa) genes, followed by ciprofloxacin on day 4. dose-independent diarrhea or change in bowel habit was seen in 3 subjects, without dysentery, vaccinaemia or serious adverse events. hematology and biochemical parameters were unchanged. doses of 10(5) or greater induced dose-indep ...200818207287
eukaryotic expression and antimicrobial spectrum determination of the peptide tachyplesin ii.ta0-a, the gene encoding the mature antimicrobial peptide tachyplesin ii, was engineered to optimize the coding sequence according to codon usage bias in yeast. ta0-a was efficiently expressed in the methylotrophic yeast pichia pastoris strain smd1168. the recombinant peptide ta0 reached 150mg/l after methanol induction for 6 d. ta0 was rapidly purified to homogeneity by a single step of size-exclusion chromatography. the minimal lethal concentrations of ta0 to the escherichia coli strain k12 wa ...200818249136
isolation and purification of enterocin e-760 with broad antimicrobial activity against gram-positive and gram-negative bacteria.strain nrrl b-30745, isolated from chicken ceca and identified as enterococcus durans, enterococcus faecium, or enterococcus hirae, was initially identified as antagonistic to campylobacter jejuni. the isolate produced a 5,362-da bacteriocin (enterocin) that inhibits the growth of salmonella enterica serovar enteritidis, s. enterica serovar choleraesuis, s. enterica serovar typhimurium, s. enterica serovar gallinarum, escherichia coli o157:h7, yersinia enterocolitica, citrobacter freundii, klebs ...200818086839
[hemolytic and uremic syndrome in the child].hemolytic and uremic syndrome (hus) is characterized by the association of hemolytic anemia with sckizocytes, thrombopenia and renal involvement secondary to thrombotic microangiopathy. the typical form is the most frequent in children occurring after an episode of diarrhea caused by escherichia coli. other microorganisms may be responsible for hus such as shigella dysenteriae or streptococcus pneumoniae. acute renal failure is reversible in most cases, but long-term renal sequelae are seen in o ...200817964233
risk areas and neighborhood-level risk factors for shigella dysenteriae 1 and shigella flexneri.annually, there are 165 million cases of shigellosis resulting in 1.1 million deaths in the developing world. two species of the causative agent, shigella dysenteriae 1 and shigella flexneri, are responsible for acute diarrheal illness. vaccines are being developed against both but many questions remain about the disease burden, distribution of species in space and time, and community-level risk factors. this study answers two questions. what are the differences in neighborhood-level risk factor ...200817602851
[analysis on incidence of bacillary dysentery in jinan municipality from 1951 to 2005].to explore the epidemic characteristics of bacterial dysentery in jinan municipality, and to provide scientific basis for effective strategy for bacterial dysentery control.200818844085
comparative study of leaf and stem bark extracts of parkia biglobosa against enterobacteria.hydroethanolic and aqueous extracts of leaf and stem bark of parkia biglobosa (jacq) benth. (mimosaceae) were tested against clinical isolates escherichia coli, salmonella typhi, shigella dysenteriae and enterococcus faecalis, and corresponding collection strains e. coli cip 105 182, salmonella enterica cip 105 150, shigella dysenteriae cip 54-51 and enterococcus faecalis cip 103 907. discs of gentamicin, a broad spectrum antibiotic were used as positive controls. the results showed that all the ...200820161943
synthesis, antimicrobial and antiinflammatory activity of 2,5-disubstituted-1,3,4-oxadiazoles.in the present study, 2,5-disubstituted-1,3,4-oxadiazoles (3a-o) have been synthesized by the condensation of 4-methoxybenzohydrazide (1) with different aromatic acids (2a-o) in presence of phosphoryl chloride. the structural assignment of this compound (3a-o) has been made on the basis of elemental analysis, uv, ir, (1)h nmr and mass spectral data. the synthesized compounds were screened for their in vitro growth inhibiting activity against different strains of bacteria and fungi viz., staphylo ...200820390080
biometric fingerprinting for visa application: device and procedure are risk factors for infection transmission.biometric fingerprint identity verification is currently introduced in visa application and entry screening at border control. the system implies physical contact between the skin and the surface of the fingerprint-capturing and reading devices.200819006507
characterization of shigella spp. by antimicrobial resistance and pcr detection of ipa genes in an infantile population from porto velho (western amazon region), brazil.the incidence of shigella spp. was assessed in 877 infants from the public hospital in rondônia (western amazon region, brazil) where shigella represents the fourth cause of diarrhea. twenty-five isolates were identified: 18 were shigella flexneri, three shigella sonnei, three shigella boydii and one shigella dysenteriae. with the exception of s. dysenteriae, all shigella spp. isolated from children with diarrhea acquired multiple antibiotic resistances. pcr detection of ipa virulence genes and ...200819057826
[structures of o-polysaccharides from two shigella dysenteriae type 8 strains].the structure of the o-polysaccharide (o-antigen) from shigella dysenteriae type 8 bacteria (strain 599) was corrected using modern nmr techniques (structure 1). the revisions concerned the position of the glc residue (in the main, but not the side, chain), the site of its substitution, and the configuration of the o-glycoside linkage of the glcnac residue. the s. dysenteriae type 8 bacterium (strain g1221), the second investigated representative, was found to produce another structural variant ...200819088755
corticosteroids in homeostasis. 20082683585
corticosteroids in homeostasis. 20082683585
antibacterial, antifungal and cytotoxic activities of amblyone isolated from amorphophallus campanulatus.to assess the in vitro antibacterial, antifungal and cytotoxic activities of amblyone, a triterpenoid isolated from amorphophallus campanulatus (roxb).200821264161
the effect of n-3 polyunsaturated fatty acids on lipids, haemostasis, neutrophil and monocyte chemotaxis in insulin-dependent diabetes mellitus.insulin-dependent diabetes mellitus (iddm) is associated with an increased risk of coronary artery disease (cad). there is some evidence that polyunsaturated fatty acids of the marine n-3 type (n-3 pufa's) may offer protection against cad. we have studied the effect of short-term dietary supplementation with n-3 pufas on lipids, haemostasis, neutrophil and monocyte chemotaxis in 10 patients with iddm. the patients were given 4 g daily of n-3 pufas (fish oil) for 6 weeks and were investigated bef ...20082706043
children's responses to different forms of expression of anger between adults.anger is not a homogeneous stimulus, but can vary on a variety of dimensions and domains. this study examined children's responses to anger as a function of: (a) the mode of expression of anger (nonverbal, verbal, verbal-physical), and (b) whether or not anger between others was resolved. children were presented with videotaped segments of angry and friendly interactions and asked questions concerning their responses. all angry interactions, including non-verbal anger, were perceived as negative ...20082612248
children's responses to different forms of expression of anger between adults.anger is not a homogeneous stimulus, but can vary on a variety of dimensions and domains. this study examined children's responses to anger as a function of: (a) the mode of expression of anger (nonverbal, verbal, verbal-physical), and (b) whether or not anger between others was resolved. children were presented with videotaped segments of angry and friendly interactions and asked questions concerning their responses. all angry interactions, including non-verbal anger, were perceived as negative ...20082612248
one year's experience using a rotating filter for therapeutic plasma exchange.the authors previously demonstrated the feasibility of using a rotating filter system for therapeutic plasma exchange. they now report on the technical details of a 1 year clinical experience. seventeen patients underwent 188 treatments. hemoaccess was provided by antecubital veins (147 rx), femoral catheters (37 rx), or an a-v fistula (3 rx). blood flows ranged from 75 to 100 ml/min. net plasma removed per treatment was 3,231 +/- 53 ml (mean +/- se, n = 188). mean plasma removal rate per treatm ...20082597461
antenatal diagnosis of parenti-fraccaro type achondrogenesis. 20082276781
the role of computerized microdiscs in dentistry. 20083462054
late brain abscess years after severe cerebrocranial trauma with fronto-orbitobasal fracture.an 8-year-old boy suffered severe craniocerebral trauma with left-sided fronto-orbitobasal fracture. the ct scan showed minor subdural air inclusions. the child recovered well and had no clinical signs of aftereffects. eight years after the accident, symptoms of intracranial pressure developed progressively with nuchal rigidity and elevated temperature. the ct showed an extensive left fronto-orbitobasal abscess. the intraoperative finding was a brain prolapse both into the frontal sinus and into ...20082736550
late brain abscess years after severe cerebrocranial trauma with fronto-orbitobasal fracture.an 8-year-old boy suffered severe craniocerebral trauma with left-sided fronto-orbitobasal fracture. the ct scan showed minor subdural air inclusions. the child recovered well and had no clinical signs of aftereffects. eight years after the accident, symptoms of intracranial pressure developed progressively with nuchal rigidity and elevated temperature. the ct showed an extensive left fronto-orbitobasal abscess. the intraoperative finding was a brain prolapse both into the frontal sinus and into ...20082736550
[ki-1 large cell lymphoma with secondary xanthomatous infiltration of the lesions by chemotherapy]. 20082575882
thermodynamic properties of globular proteins and the principle of stabilization of their native structure.a semi-empirical method has been used to estimate the thermodynamic parameters of hydration of buried surface areas of ribonuclease s, lysozyme and myoglobin from the model of complete unfolding according to ooi et al. ((1987) proc. natl. acad. sci. usa 84, 3086-3090). the buried surface area of proteins is considered as the difference between the accessible surface area of native protein and the completely extended polypeptide chain according to lee and richards ((1971) j. mol. biol. 55, 379-40 ...20082223840
synthesis and biological activity of 3-vinylthio- and 3-vinylthiomethylcephem derivatives.the synthesis and biological properties of some 3-vinylthio- and 3-vinylthiomethylcephem derivatives are described. both series possess potent antibacterial activity. among them, 3-[(z)-2-cyanovinylthiomethyl]cephem derivative was found to have an expanded antibacterial spectrum.20082211378
bilateral torsion of the normal ovary and oviduct in a young girl. 20082643670
bilateral torsion of the normal ovary and oviduct in a young girl. 20082643670
wisc-r stability and re-evaluation of learning-disabled students.this study investigated the temporal stability of wisc-r iq scores for learning-disabled subjects (n = 113). all study subjects were administered the wisc-r for an initial evaluation (m age = 8 years, 3 months) and a follow-up re-evaluation (m age = 11 years, 7 months). pearson product-moment correlations yielded coefficients that were considerably lower than those previously reported: r = .55, p less than .001 for the verbal iqs; r = .63, p less than .001 for the performance iqs; and r = .58, p ...20082613906
measles vaccine. 20082602773
fine needle aspiration biopsy in the diagnosis of thyroid cancer and thyroid disease.fine needle aspiration biopsy (fnab) performed for diffuse and nodular goiter in the past 5 years, was evaluated in 1399 cases. surgery was performed on the basis of fnab cytologic diagnosis that was positive or suggestive of malignancy and/or a suggestive clinical history. surgery also was performed in cases of cold nodules with negative fnab results that did not respond to 6 months of suppressive thyroxine therapy. a correlation of cytologic findings with histologic findings was possible in 41 ...20083815295
[diagnosis of celiac disease]. 20083614409
[evaluation of results of school health examination in the murcia region. 1986/87].in the present study, we have carried out an evaluation of school examinations in 47,943 children in the past course. we have compared our results with those from similar previous studies in other parts of spain. our findings were comparable in visual acuity and scoliosis, and not so much about cryptorchidism and phimosis. we think that examinations are necessary, but it is needed to increase the quality and the effectiveness, to get closer to the knowledge of usefulness and to the correct evalu ...20082518932
[cardiac tamponade as the first manifestation of cancer].we report 3 patients having cardiac tamponade as the initial presentation of cancer. at the onset of symptoms all three patients were incorrectly diagnosed. pulsus paradoxus and cardiomegaly on the chest x-ray were the main clinical features. two dimensional echocardiography was vital revealing massive pericardial effusion with diastolic right atrial and ventricular collapse. all patients had bloody pericardial fluid removed and the histopathology of the metastatic pericardial tissue showed lung ...20082519419
a mucin containing the x, y, and h type 2 carbohydrate determinants is shed by carcinoma cells.monoclonal antibody br 15-6a directed to the y carbohydrate determinant (fuc alpha 1----2gal beta 1----4glcnac(3----1fuc) beta 1----3gal beta 1----4glc beta 1----1cer) reacted with the cell surface and conditioned media of colorectal and breast carcinoma cell lines. double determinant immunoassays using br 15-6a as detector antibody showed that the y determinant is part of a high molecular weight mucin that coexpressed other carbohydrate antigens based on a type 2 chain (x, h type 2). type 1 cha ...20082442094
[study of the blink reflex in spinocerebellar degeneration].blink reflex (br) was composed of r1 and r2. r1 is considered to indicate the brainstem function. the purpose of this study was to evaluate the brainstem function of spinocerebellar degeneration (scd) by the r1 latency (r1). br was evoked by the percutaneous stimulation of supraorbital nerve. and r1 was measured by the action potential of orbucularis oculi muscle. direct response was recorded by the percutaneous stimulation of facial nerve to determine the terminal latency of facial nerve (d). b ...20082364628
[family dynamics of psychosocially disturbed adolescents].using a personality centered method psycho-socially disturbed adolescents aged between 17 and 22 years were treated by the intended dynamic group psychotherapy. an attempt was made to include the family in the care, which succeeded in 2/3 of the cases. the observations of the family dynamics are presented as follows: 1. a description of the dependence behaviour; 2. a phenomenologic description of disintegrating or rigid family structures; 3. the significance for therapeutic aims and prognosis is ...20082816551
[development of partner relations in very young mothers].a study was made on the development of partner relationships among adolescent mothers over a period of two years from the day of delivery onwards. from ascertained that there was still "definite marriage intention" or that the partners were interviewed at the maternity ward of the rostock county hospital and their data was compared with that of a control group of primiparae mothers (delivery age: 20-22y.). 73% of the partnerships of adolescent mothers with the child's father that existed at the ...20082816549
evaluation of children with possible appendicitis using technetium 99m leukocyte scan.we evaluated the use of technetium 99m albumin colloid white blood cell (tac-wbc) scan in 33 children with possible appendicitis. ten children had appendicitis, four of whom had perforated their appendix at the time of surgery. children with appendicitis differed from children without appendicitis in the incidence of right lower quadrant rebound tenderness (60% vs 17.4%), and white blood cell count (x10(3)/mm3) (14.0 + 1.9 vs 10.7 +/- 1.0). tac-wbc scans were interpreted as either positive, nega ...20082330248
the differential efficacy of antihypertensive agents in the elderly.a number of controlled trials have shown that antihypertensive therapy is beneficial to the elderly (greater than or equal to 60 years of age). even so, there may be deleterious age-related effects associated with such therapy. because of physiological and pathophysiological problems peculiar to the elderly (many of which remain to be defined precisely), both benefits and untoward effects of antihypertensive drugs differ, sometimes within classes of agents themselves. none of the traditional age ...20082258887
recent advances in gastrointestinal malignancy. 20082686527
recent advances in gastrointestinal malignancy. 20082686527
[sudden death of a young adult and right ventricular cardiomyopathy]. 20093207241
chronic subdural haematoma after spinal anaesthesia. case report.in this study an interesting and not frequent case of non-traumatic chronic subdural haematoma after spinal anaesthesia is reported. after a careful review of the cases described in the literature, the authors discussed the physiopathological mechanisms, emphasizing how the break of the bridge veins or of the subarachnoid granulations, the cerebral atrophy and the dehydration are factors which facilitate the appearance of this neurological complication. they suggest that a suitable post-operativ ...20094093803
chronic subdural haematoma after spinal anaesthesia. case report.in this study an interesting and not frequent case of non-traumatic chronic subdural haematoma after spinal anaesthesia is reported. after a careful review of the cases described in the literature, the authors discussed the physiopathological mechanisms, emphasizing how the break of the bridge veins or of the subarachnoid granulations, the cerebral atrophy and the dehydration are factors which facilitate the appearance of this neurological complication. they suggest that a suitable post-operativ ...20094093803
car radiator burns: a report on 72 cases.seventy-two cases of car radiator burns (crb) were treated in the burns unit, hamad medical corporation, doha, qatar, over a 6-year period (1982-87). all the patients were males and most were between 20 and 40 years old. chest wall, face and right upper limb were the commonest sites involved. most of the patients suffered from relatively minor scalds. the scenario of the accidents as well as the topography of the burned areas were characteristic to this particular type of injury. the exceptional ...20092765150
fibrinogen nagoya, a replacement of glutamine-329 by arginine in the gamma-chain that impairs the polymerization of fibrin monomer.structural studies on a hereditary abnormal fibrinogen, fibrinogen nagoya (takamatsu, j., ogata, k., kamiya, t., koie, k., takagi, t., & iwanaga, s. (1979) thromb. haemost. 42, 78), were performed to identify the abnormality responsible for the impaired polymerization of fibrin monomer. upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing conditions, fibrinogen nagoya showed the presence of an extra protein band with an apparent molecular weight of 49,500 in addition to ...20092738036
[dynamics of bile secretion under stressful conditions]. 20092702266
[cataract surgery 220 years ago].the author reports on the first 14 cataract extractions performed by karl kaspar von siebold, a würzburg surgeon, in 1766/67. he used daviel's method. at that time there was no anesthesia, no sterility or even antisepsis, and no optical correction of aphakia for his patients. four eyes were lost due to infection and another four had much poorer vision after surgery due to irregular corneal scarring. in six cases both patient and physician were satisfied with the result. siebold's case reports ex ...20092689768
[nursing career development program by private industry--from job management to career management]. 20092615507
utilization of formal social support services by non-institutionalized ill elderly. 20092948279
surrogate dentist: domestic medical guides and oral health care in the nineteenth century. 20092700922
[demands for quality and planning standards for model casting]. 20092697127
a ruptured cerebral aneurysm from choriocarcinomatous origin--a case report and a review.a case of a ruptured metastatic aneurysm of choriocarcinoma is reported. the fourteen other cases of the literature are summarized. the pathological significance of this rare presentation of metastatic disease is discussed. the treatment of choice is defined as excision followed by chemotherapy and whole brain irradiation. the prognosis remains poor.20092747937
community care--up in the air? 20092771747
the incidence and significance of seminal vesicle invasion in patients with adenocarcinoma of the prostate.the incidence and significance of seminal vesicle invasion in patients with adenocarcinoma of the prostate were determined in 139 patients who underwent radical prostatectomy. of the 36 patients who had seminal vesicle invasion, 27 (75%) also had capsular invasion and 13 (43%) had lymph node metastases. disease progression rates were 31% and 58% at 5 and 8 years, respectively. survival rate at 5 years was 90.6% and at 8 years it was 83.7%. of the 103 patients without seminal vesicle invasion, 21 ...20093815316
assessment of the character and incidence of electrocardiographic changes in children with simple obesity.the studied group comprised 82 children with simple obesity. in the group the character and frequency of ecg changes in 12 conventional leads were analyzed. a correlation was established between the character and frequency of these changes and the degree of overweight and obesity duration. in children with simple obesity a considerable prevalence was observed of disturbances of sinus rhythm, impairment of intraventricular conduction and signs of left ventricular hypertrophy. the observed changes ...20093837606
assessment of the character and incidence of electrocardiographic changes in children with simple obesity.the studied group comprised 82 children with simple obesity. in the group the character and frequency of ecg changes in 12 conventional leads were analyzed. a correlation was established between the character and frequency of these changes and the degree of overweight and obesity duration. in children with simple obesity a considerable prevalence was observed of disturbances of sinus rhythm, impairment of intraventricular conduction and signs of left ventricular hypertrophy. the observed changes ...20093837606
blood clonal b cell excess (cbe) at diagnosis in patients with non-hodgkin lymphoma (nhl). relation to clinical stage, histopathology and response to treatment.untreated non-leukemic (lymphocytes less than or equal to 4.0 x 10(9)/l) patients with non-hodgkin lymphoma (nhl) of b cell type often show an excess of b cells in peripheral blood bearing the same light chain isotype as the lymph node tumor cells which may indicate a leukemic spread of the disease. the ratio between kappa- and lambda-bearing lymphocytes (normal range 1.0-3.3) was studied to evaluate the prognostic significance of clonal b cell excess (cbe) at diagnosis in 110 nhl patients. in t ...20093115783
[computerized tomography symptoms in 2 cases of primary linitis plastica of the rectum]. 20092844723
panic attack-associated placental abruption: a case report.a case of placental abruption is described in a nonmedicated pregnant woman with panic disorder who experienced panic symptoms and resultant hypertension. the authors suggest that sympathetic arousal associated with panic symptoms may have an adverse effect on the fetoplacental unit. the potential impact of untreated anxiety symptoms on fetal well-being must be considered when deciding whether pharmacotherapeutic intervention is appropriate for certain patients with anxiety disorders.20092738032
convergence to stationary distributions in two-species stochastic competition models.two sets of sufficient conditions are given for convergence to stationary distributions, for some general models of two species competing in a randomly varying environment. the models are nonlinear stochastic difference equations which define markov chains. one set of sufficient conditions involves strong continuity and phi-irreducibility of the transition probability for the chain. the second set has a much weaker irreducibility condition, but is only applicable to monotonic models. the results ...20092769087
lead toxicity and iron deficiency in utah migrant children.we determined the frequency of presumptive iron deficiency and lead toxicity in 198 utah migrant children, ages 9-72 months, during the summer of 1985. there were no confirmed cases of lead toxicity. thirteen per cent of those tested and 30 per cent of the children ages 9-23 months were iron deficient. hematocrit determinations accurately predicted iron deficiency in only 35 per cent of the children confirmed to have this disorder via erythrocyte protoporphyrin screening.20092650572
lead toxicity and iron deficiency in utah migrant children.we determined the frequency of presumptive iron deficiency and lead toxicity in 198 utah migrant children, ages 9-72 months, during the summer of 1985. there were no confirmed cases of lead toxicity. thirteen per cent of those tested and 30 per cent of the children ages 9-23 months were iron deficient. hematocrit determinations accurately predicted iron deficiency in only 35 per cent of the children confirmed to have this disorder via erythrocyte protoporphyrin screening.20092650572
31p-nmr study on intracellular energy transport in muscle. 20092798486
31p-nmr study on intracellular energy transport in muscle. 20092798486
levels and sources of stress in medical students.levels of stress, as measured by the general health questionnaire, were assessed in 318 medical students in their fourth year at three british universities. mean scores were higher than those in other groups within the general population, and the estimated prevalence of emotional disturbance was 31.2%, a proportion similar to that reported in medical students in the united states. there were no differences in prevalence or in mean scores of stress between the sexes. twelve (4%) students reported ...20093085772
frequency of isolation of various subtypes and antimicrobial resistance of shigella from urban slums of karachi, pakistan.shigellosis remains a major public health problem in developing countries. antimicrobial resistance has complicated the empirical treatment. knowledge of serotypes is crucial in vaccine development, as cross-protection between various serotypes is limited. therefore we conducted a prospective study to determine the frequency of isolation of shigella serotypes and antimicrobial resistance.200919135399
safety and immunogenicity of sc599, an oral live attenuated shigella dysenteriae type-1 vaccine in healthy volunteers: results of a phase 2, randomized, double-blind placebo-controlled trial.sc599 vaccine is a live shigella dysenteriae 1 strain attenuated by deletion of invasion [icsa], iron chelation [ent, fep] and shiga toxin a subunit [stxa] genes. in a preliminary phase 1 single dose prospective study, we showed that sc599 vaccine was well tolerated, and the maximum tolerable dose was greater than 10(8) cfu [sadorge c, ndiaye a, beveridge n, frazer s, giemza r, jolly n, et al. phase 1 clinical trial of live attenuated shigella dysenteriae type-1 deltaicsa deltaent deltafep delta ...200919135496
rapid dna amplification using a battery-powered thin-film resistive thermocycler.a prototype handheld, compact, rapid thermocycler was developed for multiplex analysis of nucleic acids in an inexpensive, portable configuration. instead of the commonly used peltier heating/cooling element, electric thin-film resistive heater and a miniature fan enable rapid heating and cooling of glass capillaries leading to a simple, low-cost thin-film resistive thermocycler (tfrt). computer-based pulse width modulation control yields heating rates of 6-7 k/s and cooling rates of 5 k/s. the ...200919159110
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