Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| genomic diversity of human papillomavirus-16, 18, 31, and 35 isolates in a mexican population and relationship to european, african, and native american variants. | cervical cancer, mainly caused by infection with human papillomaviruses (hpvs), is a major public health problem in mexico. during a study of the prevalence of hpv types in northeastern mexico, we identified, as expected from worldwide comparisons, hpv-16, 18, 31, and 35 as highly prevalent. it is well known that the genomes of hpv types differ geographically because of evolution linked to ethnic groups separated in prehistoric times. as hpv intra-type variation results in pathogenic differences ... | 2004 | 14980491 |
| prognostic significance of lymph node variables and human papillomavirus dna in invasive vulvar carcinoma. | the present study investigates the influence of lymph node pathological features and hpv dna status on the prognosis of vulvar invasive tumors. | 2004 | 14984953 |
| a phase ii trial of interleukin-12 in patients with advanced cervical cancer: clinical and immunologic correlates. eastern cooperative oncology group study e1e96. | the ability to mount lymphoproliferative responses to peptides derived from the human papillomavirus (hpv) e6 and e7 oncoproteins has been associated with regression of dysplastic lesions of the uterine cervix and loss of associated hpv infection. interleukin-12 (il-12) is a potent immunopotentiator of t-cell function, and has been shown in phase i clinical trials to be tolerable. | 2004 | 14984966 |
| antiretroviral therapy and the clinical evolution of human papillomavirus-associated genital lesions in hiv-positive women. | the effect of antiretroviral therapy on the natural history of human papillomavirus (hpv)-associated genital lesions was evaluated in 201 human immunodeficiency virus (hiv)-infected women who were followed-up for 1-6 years. gynecologic examinations were performed every 6-12 months. hpv sequences in cervico-vaginal cells, analyzed by polymerase chain reaction and typed by restriction fragment-length polymorphism analysis, were repeatedly detected in 126 women; 29 had transient hpv infection. geni ... | 2004 | 14986260 |
| cisplatin restores p53 function and enhances the radiosensitivity in hpv16 e6 containing siha cells. | most hpv-positive cervical cancer cells possess wild type p53 gene, but its normal p53 functions are disrupted by expression of hpvs e6. treatment with 0-20 microm cisplatin for 24 h in hpv16 e6 containing siha cells suppressed e6 mrna, reduced e6 protein, and restored p53 expression in dose-dependent manners. dual-parameter flow cytometric analysis indicated that sub-g(1) apoptotic cells, but not necrotic cells were the major species for cisplatin-induced cytotoxicity in siha cells. after 0-10 ... | 2004 | 14991767 |
| human papillomavirus genotyping by the dna chip in the cervical neoplasia. | human papillomavirus (hpv) is implicated as an etiologic agent in neoplasitc lesions of the cervix. in this study, we used an hpv dna chip to detect the type-specific sequence of hpv from cervical swabs in women with biopsy- proven neoplastic lesions of the cervix. four hundred seventy-one patients were involved and classified into four groups based on the cytopathologic diagnosis: group i (normal, n = 290), group ii (low-grade squamous intraepithelial lesions (sil), n = 68), group iii (high-gra ... | 2004 | 15000752 |
| cancer of the anal canal. | anal cancer is an uncommon tumour that represents 4% of all cancers of the lower gastrointestinal tract. its pathogenesis and treatment have undergone substantial reassessment over the past two decades, and this is likely to continue. anal cancer can be cured by synchronous chemoradiotherapy, a treatment that both enables anal continence to be retained and reserves abdominoperineal resection of the rectum and anal canal (with formation of a permanent colostomy) for recurrent or residual disease ... | 2004 | 15003197 |
| human papillomavirus-32-positive extragenital bowenoid papulosis (bp) in a hiv patient with typical genital bp localization. | bowenoid papulosis (bp) is characterized by multiple maculopapular lesions of the genitalia; extragenital localization is rarely found. human papillomavirus (hpv) type 16 has been found in most cases of bp, but the other hpv genotypes associated with bp had been poorly characterized. | 2004 | 15389001 |
| adjunctive treatment with interferon alpha-2b may decrease the risk of papilloma-associated conjunctival intraepithelial neoplasm recurrence. | to report a case of bilateral papilloma virus-positive conjunctival intraepithelial neoplasm and the treatment results of using adjunctive interferon alpha-2b. | 2004 | 15448502 |
| human papillomavirus and cervical cytology in adolescents. | human papillomavirus (hpv) infection is highly prevalent in adolescent girls and young women and may be associated with substantial morbidity and mortality. hpv infection may lead to condylomata (genital warts), cervical intraepithelial neoplasia (cin), and cervical cancer. recent research focused on the virology, natural history, and sequelae of hpv infection has led to evidence-based revisions of the system for classification of cervical cytology results, recommendations for cytologic screenin ... | 2004 | 15449847 |
| lactoferrin inhibits human papillomavirus binding and uptake in vitro. | lactoferrin (lf), a member of the transferrin family, is a bi-globular protein secreted in milk, saliva, tears, seminal fluid, endocervix and vaginal secretions. lf is an important player in the defence against pathogenic microorganisms and has also been shown to have activity against several viruses including herpesvirus, adenovirus, rotavirus and poliovirus. the antiviral activity of lf is directed against the early steps of viral infection and the lf antiviral effect against herpesvirus is me ... | 2004 | 15451180 |
| identification of an hnrnp a1-dependent splicing silencer in the human papillomavirus type 16 l1 coding region that prevents premature expression of the late l1 gene. | we have previously identified cis-acting rna sequences in the human papillomavirus type 16 (hpv-16) l1 coding region which inhibit expression of l1 from eukaryotic expression plasmids. here we have determined the function of one of these rna elements, and we provide evidence that this rna element is a splicing silencer which suppresses the use of the 3' splice site located immediately upstream of the l1 aug. we also show that this splice site is inefficiently utilized as a result of a suboptimal ... | 2004 | 15452209 |
| molecular analysis of the effect of topical imiquimod treatment of hpv 2/27/57-induced common warts. | imiquimod is effective in the treatment of genital warts and clinical studies suggest activity against common warts as well. we have analyzed the effect of topical imiquimod on gene expression and virus load in human papilloma virus (hpv) 2/27/57-induced common warts. mrna was extracted from keratinocyte culture, from normal skin, from three untreated common warts and from three common warts treated topically with 5% imiquimod cream twice daily. differential gene expression was demonstrated by r ... | 2004 | 15452412 |
| immunocytochemical staining of p16ink4a protein from conventional pap test and its association with human papillomavirus infection. | the p16ink4a protein is immunocytochemically detected in liquid-based (lb) specimens as a diagnostic marker of cervical dysplasia and neoplasia. its up-regulation is promoted by high-risk human papillomavirus (hr-hpv) infection. we aimed to detect p16ink4a on conventional papanicolaou (pap) test (cpt) slides and to determine the relationship between its overexpression and hr-hpv infection. cpt and lb pap test (lbpt) slides (165 samples of each) were examined by immunocytochemical staining for p1 ... | 2004 | 15452898 |
| [occurrence of human papillomavirus is a positive factor in tonsillar cancer. reduced risk of recurrence and longer survival]. | the purpose of this article is to review the current knowledge on the status and significance of human papillomavirus (hpv) in tonsillar cancer. current data demonstrate that approximately half of all tonsillar cancer is hpv positive. moreover, patients with hpv positive cancer have a less risk of relapse and have a longer survival compared to patients with hpv negative tonsillar cancer. the longer survival is not dependent on that hpv positive tonsillar cancer is more sensitive to radiation the ... | 2004 | 15457821 |
| human keratin 14 driven hpv 16 e6/e7 transgenic mice exhibit hyperkeratinosis. | human papillomavirus type 16 (hpv16) has been known as a major causative factor for the development of uterine cervical carcinomas. to investigate the in vivo activity of hpv16 expressed in squamous epithelia, transgenic mice harboring hpv16 e6/e7 with human keratin 14 (hk14) promoter were generated. grossly, hk14 driven hpv16 e6/e7 transgenic mice exhibited multiple phenotypes, including wrinkled skin that was apparent prior to the appearance of hair in neonates, thickened ears, and loss of hai ... | 2004 | 15474555 |
| urethral condyloma acuminata following urethral instrumentation in an elderly man. | a 70-year-old man had undergone urethral dilatation with bougie for 8 months following transurethral resection of the prostate and complained papillary masses at the urethral meatus. physical and endoscopic examination revealed multiple tumors from the urethral meatus to the bulbous urethra. these tumors were resected transurethrally and 5-fu cream was instilled into urethra. microscopic examination revealed urethral condyloma acuminata. human papillomavirus types 6/11 were detected in the condy ... | 2004 | 15479306 |
| [detection of chlamydia trachomatis in cervical smear samples with determined hpv]. | chlamydia trachomatis (ct) causes infertility, ectopyc pregnancy, pelvic inflammatory disease (pid) and conjunctivitis. human papilloma virus (hpv) is a virus with broad spectrum effects. this particularly refers to hpv of high oncogenic potential (hpv - hr) because of its participation in cervical oncogenesis. the authors wanted to determine correlation between cervical hpv infection and detection of ct taken from female patient's smear of different levels of cervical intraepithelial neoplasm ( ... | 2004 | 15484852 |
| equine papillomavirus type 1: complete nucleotide sequence and characterization of recombinant virus-like particles composed of the ecpv-1 l1 major capsid protein. | equus caballus papillomavirus type 1 (ecpv-1) was isolated from a cutaneous papilloma, the most common neoplasm in horses. the complete ecpv-1 nucleotide sequence and genomic organization were determined. phylogenetic analysis showed that ecpv-1 is a close-to-root papillomavirus, with only distant relationships to the fibropapillomaviruses and the benign cutaneous papillomaviruses. to produce ecpv-1 virus-like particles (vlps), the ecpv-1 l1 major capsid protein was expressed in insect cells usi ... | 2004 | 15485669 |
| development and characterization of a rabbit corneal endothelial cell line. | to develop a rabbit corneal endothelial cell line by transducing human papilloma virus (hpv) type 16 e6 and e7 oncogenes, and to characterize the inherent biological properties of the established cell line. | 2004 | 15486767 |
| topical 5-aminolaevulinic acid-photodynamic therapy for the treatment of urethral condylomata acuminata. | electrocoagulation and laser evaporation for urethral condylomata acuminata have high recurrence rates and can be associated with urethral malformations. | 2004 | 15491431 |
| persistent hpv infection in postmenopausal age women. | persistence of human papillomavirus (hpv) is associated with an increased risk of developing cervical sil and cancer in young women. because this association in older, postmenopausal age women has received little attention, we evaluated persistence of hpv among women in this age group. | 2004 | 15491557 |
| treatment of undifferentiated vulvar intraepithelial neoplasia with 5% imiquimod cream: a prospective study of 12 cases. | to assess the efficacy of 5% imiquimod cream on undifferentiated vulvar intraepithelial neoplasia (vin), a disease caused by high-risk human papillomavirus. | 2004 | 15492184 |
| factors associated with hpv persistence after treatment for high-grade cervical intra-epithelial neoplasia with large loop excision of the transformation zone (lletz). | human papillomavirus (hpv) persistence after high-grade cervical intra-epithelial neoplasia (cin) removal may be associated with residual lesions or risk of disease recurrence. knowledge regarding the factors associated with hpv persistence following cin treatment is still limited. the main purpose of this longitudinal study was to assess the association between characteristics of the patients and their cervical lesions with high-risk hpv-type persistence, detected by commercially available hybr ... | 2004 | 15494268 |
| managing the sexually transmitted disease pandemic: a time for reevaluation. | the serious implications of the sexually transmitted disease (std) pandemic that currently challenges educators, medical practitioners and governments suggest that prevention strategies, which primarily focus on barrier protection and the management of infection, must be reevaluated and that initiatives focusing on primary prevention of behaviors predisposing individuals to std risk must be adopted. human immunodeficiency virus/acquired immunodeficiency syndrome, human papillomavirus, genital he ... | 2004 | 15507928 |
| reproductive tract infections in rural women from the highlands, jungle, and coastal regions of peru. | to define the prevalences and manifestations of reproductive tract infections (rtis) in rural peruvian women. | 2004 | 15508193 |
| regression of low-grade squamous intra-epithelial lesions in young women. | the aim of this study was to assess the probability of low-grade squamous intra-epithelial lesion (lsil) regression in young women, and to examine the factors associated with this regression. | 2004 | 15530628 |
| phase 1 study of hpv16-specific immunotherapy with e6e7 fusion protein and iscomatrix adjuvant in women with cervical intraepithelial neoplasia. | persistent infection of cervical epithelium with "high risk" human papillomavirus (hpv) results in cervical intraepithelial neoplasia (cin) from which squamous cancer of the cervix can arise. a study was undertaken to evaluate the safety and immunogenicity of an hpv16 immunotherapeutic consisting of a mixture of hpv16 e6e7 fusion protein and iscomatrix adjuvant (hpv16 immunotherapeutic) for patients with cin. | 2004 | 15531034 |
| p53 codon 72 polymorphic variants, loss of allele-specific transcription, and human papilloma virus 16 and/or 18 e6 messenger rna expression in squamous cell carcinomas of the head and neck. | a polymorphism at codon 72 of the human tumor suppressor p53 determines translation into either arginine or proline. yet, the impact of this amino acid variability on the risk to develop malignant tumors, particularly carcinomas associated with human papilloma virus (hpv) infections, remains unresolved because of contradictory results. to address a potential correlation between the different genotypes and the manifestation of squamous cell carcinomas of the head and neck (scchn), we determined t ... | 2004 | 15533911 |
| evaluation of log-rank tests for infrequent observations from a multi-state process, with application to hpv vaccine efficacy. | genital infection by human papillomavirus (hpv) is a common sexually transmitted disease, with over 25 per cent prevalence among young women in the us. infections are usually without symptoms and transient (or reversible), but a small proportion of infections persist and are believed to be responsible for nearly all cervical cancers and precursor lesions such as cervical intraepithelial neoplasia (cin). therefore, successful vaccines against persistent hpv infections could have a great impact in ... | 2004 | 15534891 |
| detection of high-risk hpv dna in semen and its association with the quality of semen. | the effects of seminal high-risk human papillomavirus (hpv) dna were assessed on the quality of semen. semen samples of 65 men participating in the ongoing finnish hpv family study were collected. semen analyses were done by the guidelines of the nordic association for andrology. hpv dna was detected by nested polymerase chain reaction and confirmed by southern blot hybridization for high-risk types. altogether, 10/65 men (15.4%) had high-risk hpv dna positive semen sample. seminal high-risk hpv ... | 2004 | 15537460 |
| bowenoid papulosis at the site of prior herpes progenitalis. | a 35-year-old dentist came to the authors' attention for papular and vegetating lesions that had appeared on his penile shaft over the last 2 months. the lesions differed in their features: pink and vegetating on the left side, brown and papular on the right side (figure 1). the obvious clinical diagnoses of genital warts on the left and bowenoid papulosis on the right were confirmed by punch biopsies, which showed epithelial hyperplasia with diffuse cell vacuolization (koilocytes)in the left bi ... | 2004 | 15538089 |
| elevated amount of human papillomavirus 31 dna in a squamous cell carcinoma developed from bowenoid papulosis. | a 50-year-old woman presented with asymptomatic, multiple black macules on the genitalia for 6 months. she presented multiple, round to irregularly shaped, black macules on her labia major and perineum. a keratotic reddish nodule was found on one of the macules. the results of laboratory investigations showed pancytopenia and a decreased cd4/cd8 ratio. a lymphocyte stimulation test showed a decreased response. the histological examination of a biopsy specimen led us to the diagnosis of bowenoid ... | 2004 | 15539898 |
| apoptosis-related proteins and cervical intraepithelial neoplasia in human immunodeficiency virus-seropositive women. | to evaluate the expression of bcl-2, p-53, ki-67, and apoptosis as evidenced by nuclear dna fragmentation in cervical biopsies obtained from human immunodeficiency virus (hiv)-seropositive and hiv-seronegative women with a history of intravenous drug abuse. | 2004 | 15581953 |
| efficacy of a bivalent l1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial. | vaccination against the most common oncogenic human papillomavirus (hpv) types, hpv-16 and hpv-18, could prevent development of up to 70% of cervical cancers worldwide. we did a randomised, double-blind, controlled trial to assess the efficacy, safety, and immunogenicity of a bivalent hpv-16/18 l1 virus-like particle vaccine for the prevention of incident and persistent infection with these two virus types, associated cervical cytological abnormalities, and precancerous lesions. | 2004 | 15541448 |
| plasmid encoding papillomavirus type 16 (hpv16) dna constructed with codon optimization improved the immunogenicity against hpv infection. | human papillomavirus type 16 (hpv16) infections can cause neoplasia, which is thought to be closely associated with the development of cervical cancers. in the study, we attempted to construct a dna plasmid encoding a hpv16 capsid protein (l1) and a hpv16 oncoprotein (e7), which was capable of preventing hpv16 infection and eliminating hpv16-infected cells. a plasmid, l1e7hpsca1, encoding the l1 and e7 genes with the codon usage optimized for mammalian cell expression, was constructed. mutations ... | 2004 | 15542183 |
| [descriptive study of hpv prevalence in a private consultation]. | human papillomavirus (hpv) infection is the main aethiological factor in the development of squamous cervical neoplasia. nowadays molecular hybridization is the most adequated method to detect hpv. study is based on the hpv assay by means of mixed hybridization and capture of specific sequences of viral dna. detection of hpv by hybridization and capture is a very useful technique in patients with non-definitive cytologies of viral action, but that display high clinical suspect for such a infecti ... | 2004 | 15587292 |
| [cervical cancer. current view of its epidemiology and risk factors]. | an epidemiologic analysis and a global evaluation of risk factors related to the etiopathogenesis of cervical cancer are reported here. cervical cancer is the second cause of female malignancies worldwide and represents a health problem in some countries of africa and latin america like haiti, zimbabwe, bolivia and ecuador, with incidence rates from 44.2 to 93.9 per 100,000. highest death rates are reported in haiti, nicaragua, ecuador and mexico (53.5 to 17.1 per 100,000, respectively). althoug ... | 2004 | 15587822 |
| evidence for practice: oral contraception and risk of cervical cancer. | the issue of continued oral contraceptive use among women with abnormal pap smears may be controversial due to reported evidence of an increased risk of cervical cancer among long term oral contraceptive users. this article reviews the evidence concerning oral contraception and cervical cancer risk. the role of human papilloma virus (hpv) and proposed mechanisms for the development of cervical cancer are explained. evidence from world health organization (who) studies and additional research evi ... | 2004 | 15543923 |
| hybrid capture 2 viral load and the 2-year cumulative risk of cervical intraepithelial neoplasia grade 3 or cancer. | the purpose of this study was to determine the clinical value of a semiquantitative measure of human papillomavirus viral load by the hybrid capture 2 assay for stratification of the risk of histologic cervical intraepithelial neoplasia grade 3 or carcinoma. | 2004 | 15547529 |
| evaluating human papillomavirus vaccination programs. | human papillomavirus (hpv) has been implicated as the primary etiologic agent of cervical cancer. potential vaccines against high-risk hpv types are in clinical trials. we evaluated vaccination programs with a vaccine against hpv-16 and hpv-18. we developed disease transmission models that estimated hpv prevalence and infection rates for the population overall, by age group, by level of sexual activity within each age group, and by sex. data were based on clinical trials and published and unpubl ... | 2004 | 15550200 |
| incidence, duration, and determinants of cervical human papillomavirus infection in a cohort of colombian women with normal cytological results. | data on the incidence and determinants of human papillomavirus (hpv) infection in women >30 years old are scarce. to address this, a cohort of 1610 women--15-85 years old, hpv negative, and with normal cytological results at baseline--was monitored every 6 months for an average of 4.1 years. information on risk factors and cervical samples for cytological testing and detection and typing of hpv dna were obtained at each visit. the incidence of high-risk types was higher than that of low-risk typ ... | 2004 | 15551205 |
| incidence, pathophysiology and treatment of cervical cancer. | cervical cancer is the third most common cancer affecting women. while not in itself a sexually transmitted disease, cervical cancer is linked to the presence of the human papilloma virus, which is sexually transmitted. survival rates are significantly higher where diagnosis is early, and a national screening programme has reduced mortality in the uk. however, uptake is low in some groups and nurses have a role in increasing uptake. | 2004 | 15552491 |
| correlation of immunochemical detection of hpv l1 capsid protein in pap smears with regression of high-risk hpv positive mild/moderate dysplasia. | to immunostain pap smears of high-risk (hr) hpv dna-positive early squamous lesions for detecting hpv l1 protein. | 2004 | 15560527 |
| [correlation between dna load of human papillomavirus and recurrence of condyloma acuminata]. | to determine the correlation between dna load of human papillomavirus (hpv) and recurrence of condyloma acuminata (ca). | 2004 | 15562772 |
| [correlation between p53 codon 72 polymorphism and tumorigenesis of cervical cancer]. | the p53 codon 72 polymorphism affects human papillomavirus (hpv) e6-mediated degradation of p53. this study was to investigate distribution of p53 polymorphism in guangdong women, and relationship between p53 polymorphism and tumorigenesis of cervical cancer. | 2004 | 15566643 |
| therapy of cutaneous human papillomavirus infections. | human papillomaviruses (hpv) are double-stranded dna viruses, which result in a variety of clinical manifestations according to type. the most common cutaneous lesions include warts located on the skin and genitalia. because there is currently no cure for hpv infection, treatment focuses on the alleviation of signs and symptoms. unfortunately, therapy has not been proved to affect transmissibility. traditional treatment modalities have focused on the destruction of infected tissue through a vari ... | 2004 | 15571494 |
| functional genetic screen for genes involved in senescence: role of tid1, a homologue of the drosophila tumor suppressor l(2)tid, in senescence and cell survival. | we performed a genetic suppressor element screen to identify genes whose inhibition bypasses cellular senescence. a normalized library of fragmented cdnas was used to select for elements that promote immortalization of rat embryo fibroblasts. fragments isolated by the screen include those with homology to genes that function in intracellular signaling, cellular adhesion and contact, protein degradation, and apoptosis. they include mouse tid1, a homologue of the drosophila tumor suppressor gene l ... | 2004 | 15572682 |
| inhibited interpersonal coping style predicts poorer adherence to scheduled clinic visits in human immunodeficiency virus infected women at risk for cervical cancer. | one of the most common gynecologic conditions among hiv+ women is cervical dysplasia, the precancerous phase of cervical cancer. therefore, adherence to gynecology visits may be among the most important health care practices for hiv+ women. however, no research has evaluated the psychosocial factors associated with health care practices among hiv+ women at risk for cervical cancer. | 2004 | 15576258 |
| disseminated human papillomavirus type 11 infection in a patient with pemphigus vulgaris: confirmed by dna analysis. | depending on the type of epithelium infected, human papillomaviruses (hpvs) are often subclassified as "cutaneous" or "mucosal" types of hpv. hpv type 11 is a mucosal type of virus and infects the genital tract or larynx. disseminated hpv-11 infection involving multiple body sites in cases of pemphigus vulgaris (pv) has not been reported. we report here an unusual case of severe pemphigus vulgaris associated with disseminated hpv-11 infection on the arms, hands, axillae, chest, abdomen, and both ... | 2004 | 15577767 |
| treatment of bowenoid and basaloid vulvar intraepithelial neoplasia 2/3 with imiquimod 5% cream. | to evaluate the effectiveness and safety of imiquimod 5% for the treatment of bowenoid and basaloid vulvar intraepithelial neoplasia (vin) and to evaluate recurrences following treatment. | 2004 | 15603097 |
| [effect of anti-hpv16 e6-ribozyme on cell proliferation and invasiveness of cervical carcinoma cell line caski]. | to investigate the effects of anti-hpv16-ribozyme on the cell proliferation and invasiveness of cultured cervical cancer cell line caski. | 2004 | 15604060 |
| [genital condylomatosis and pregnancy associated with chorioamnionitis and premature delivery]. | genital condylomas are produced by the human papilloma virus. on many occasions they are associated with other genital infections (fungi, trichomonas and vaginosis). pregnancy favours the appearance of condylomas in the anogenital region. on the occasion of a case of genital condylomatosis associated with chorioamnionitis that resulted in a premature delivery, we carry out a review the literature. | 2004 | 15644890 |
| reflections on cervical cancer. | the incidence of invasive cervical cancer and consequently mortality decreased due to adequate screening programmes in canada from 1969 to 2003. systematic cervical screening programmes similar to those in europe should be implemented throughout canada. the new techniques, including a liquid-based cytology, associated or not with identifying human papilloma virus (hpv), allow the best results in prevention and early diagnosis of cervical cancer and high-grade squamous intraepithelial lesions (hs ... | 2004 | 15597840 |
| low-dose topical delivery of all-trans retinoic acid for cervical intraepithelial neoplasia ii and iii. | the objective of this study was to determine an effective dose for all-trans retinoic acid (atra) delivered with a cervical cap and sponge for 4 days to women with cervical intraepithelial neoplasia (cin) ii/iii. | 2004 | 15598773 |
| distribution and prevalence of human papillomavirus genotypes in routine pap smear of 2,470 korean women determined by dna chip. | we examined human papillomavirus (hpv) genotype distribution and prevalence from routine pap smear cases in korean women using dna chip. patients and | 2004 | 15598774 |
| a case of bowenoid papulosis of the penis successfully treated with topical imiquimod cream 5%. | bowenoid papulosis is a pre-malignant condition affecting the ano-genital area. pathogenesis may be associated with high-risk human papillomavirus genotypes, and sexual transmission is the most likely mode of acquisition. risk of progression to invasive disease is low. treatment usually involves locally destructive or ablative therapies. we report well-tolerated, successful clearance of bowenoid papulosis of the penis in a 25-year-old male, using topical aldara (imiquimod) cream 5%, once every o ... | 2004 | 15601490 |
| [effects of imiquimod on latent human papillomavirus anal infection in hiv-infected patients]. | high risk human papillomaviruses (hpv) have emerged as risk factors for anal carcinoma particularly in hiv-infected patients who demonstrate a high rate of anal hpv infection. considering the relationship between the presence of anal infection and the development of neoplastic lesions, we wished to assess the capacity of imiquimod to eradicate latent hpv infection in hiv-infected patients. | 2004 | 15602380 |
| operative treatment of cervical premalignant lesions and the presence of high-risk human papilloma virus as etiologic agent. | the conization as an excisional method is used as an operative treatment of high-risk premalignant cervical lesions. early detection and removal may stop the developing process that leads to invasive carcinoma. the study presents a group of 100 women, operated with "cold knife" conization during the year 2002 at the 1st operative oncologic department of the gynecology and obstetrician clinic - medical faculty, skopje. the operative material showed cin 2 in 2 and cin 3 in 31 women. in 7 of them, ... | 2004 | 15658576 |
| testing positive for human papillomavirus in routine cervical screening: examination of psychosocial impact. | to examine the psychosocial impact of testing positive for high risk human papillomavirus (hpv) among women attending primary cervical screening. | 2004 | 15663132 |
| matrix metalloproteinase-2, squamous cell carcinoma antigen, and tissue polypeptide-specific antigen expression in egyptian patients with cervical carcinoma: relationship with prognosis. | matrix metalloproteinases (mmps), a family of proteolytic enzymes produced by both stromal and tumor cells, appear to have a key role in the events leading to local invasion and metastasis by malignant neoplasms. in the present study, we evaluated the role of mmp-2, squamous cell carcinoma antigen (scca), and tissue polypeptide - specific antigen (tps) in cervical neoplasia. using western blotting and enzyme immunoassay (eia), we analyzed 50 patients with cervical carcinoma (cc) and 25 normal co ... | 2004 | 15665394 |
| [papilloma virus infection in pretumor and tumor masses of the larynx]. | there has been recent evidence suggesting that papilloma virus infection is of no small importance in the pathogenesis of tumors of the head and neck. this study has involved a screening of the mucosa having laryngeal pretumors and tumors for papilloma virus infection by polymerase chain reaction and immunohistochemistry. specimens were studied in 130 patients. all the patients with laryngeal papillomatosis were found to have human papilloma virus (hpv) types 6 and 11. hpv-18 was detected in 6 ( ... | 2004 | 15678687 |
| genomic and proteomic expression patterns in hpv-16 e6 gene transfected stable human carcinoma cell lines. | cdna microarray and proteomics studies were performed to analyze the genomic and proteomic expression patterns in hpv-16 e6 gene transfected stable human carcinoma cell lines. among 1024 known genes and ests tested by cdna microarray, we found 50 upregulated and 35 downregulated genes in rc10.1 hpv-16 e6 transfected human colon adenocarcinoma cells compared to rko cells, and 27 upregulated and 43 downregulated genes in a549e6 hpv-16 e6 transfected human lung adenocarcinoma cells compared to a549 ... | 2004 | 15684709 |
| risk factors for cervical cancer development: what do women think? | the current cervical cancer prevention strategy is exclusively directed towards screening, without taking into account any relationship with sexual risk factors. the introduction of human papillomavirus (hpv) detection into the screening procedure implicates that we should give attention to this relationship. the aim of this study was to investigate what knowledge women have of the relation between hpv and cervical cancer. | 2004 | 16335302 |
| characterization of dna vaccines encoding the domains of calreticulin for their ability to elicit tumor-specific immunity and antiangiogenesis. | antigen-specific cancer immunotherapy and antiangiogenesis are feasible strategies for cancer therapy because they can potentially treat systemic tumors at multiple sites in the body while discriminating between neoplastic and non-neoplastic cells. we have previously developed a dna vaccine encoding calreticulin (crt) linked to human papillomavirus-16 e7 and have found that this vaccine generates strong e7-specific antitumor immunity and antiangiogenic effects in vaccinated mice. in this study, ... | 2004 | 15893626 |
| [a case of dandy-walker malformation futus and 18-trisomy]. | 2004 | 16136993 | |
| [association between high-risk human papillomavirus dna load and cervical intraepithelial lesion]. | to determine the association between viral load of high risk type human papillomavirus (hr-hpv) and stage of cervical intraepithelial neoplasia (cin) lesion. | 2004 | 15769315 |
| changing patterns of sexually transmitted infections in india. | sexually transmitted infections (stis) are more dynamic than other diseases prevailing in the community. their epidemiological profile varies from country to country and from one region to another within a country, depending upon ethnographic, demographic, socioeconomic and health factors. the clinical pattern is also a result of the interaction among pathogens, the behaviours that transmit them and the effectiveness of preventive and control interventions. we reviewed the changing patterns of d ... | 2004 | 15736552 |
| optimal cutoff of the hybrid capture ii human papillomavirus test for self-collected vaginal, vulvar, and urine specimens in a colposcopy referral population. | to estimate the optimal relative light unit ratio, as a measure of viral load, of the hybrid capture ii human papillomavirus (hpv) test in self-collected specimens for detecting cervical intraepithelial neoplasia (cin). | 2004 | 15874834 |
| performance of direct visual inspection of the cervix with acetic acid and magnification in a previously screened population. | to assess the screening performance of direct visual inspection with acetic acid and x2 magnification (viam) in a previously screened population, as performed by experienced gynecologic nurses with minimal training in viam. | 2004 | 15874851 |
| beyond human papillomavirus: the cervix, exogenous secondary factors, and the development of cervical precancer and cancer. | human papillomavirus (hpv) is the necessary but probably not sufficient cause of cervical precancer and cancer. secondary exogenous and endogenous factors, hpv cofactors, may contribute to the probability of a cancer-associated (oncogenic) hpv infection progressing to cervical precancer and cancer. for these cofactors to influence the natural history of hpv infection, they must act on cervical tissue to promote viral persistence, progression to precancer or cancer given viral persistence, or bot ... | 2004 | 15874868 |
| false-negative hybrid capture ii results related to altered adhesion molecule distribution in women with atypical squamous cells pap smear results and tissue-based human papillomavirus-positive high-grade cervical intraepithelial neoplasia. | we investigated the detection of high-risk human papillomavirus dna with the hybrid capture ii test (hcii; digene corporation, beltsville, md) and the presence and pattern of distribution of adhesion molecules in biopsy-proven high-grade neoplastic lesions containing high-risk hpv-dna from women with asc cytology results. | 2004 | 15874874 |
| a tailored multi-media campaign to promote the human papillomavirus cohort study to young women. | human papillomavirus (hpv), a sexually transmitted disease, is now recognized as the major cause of cervical cancer. the cancer research center of hawaii developed a low-cost and culturally sensitive multimedia campaign to recruit oahu women to their hpv cohort study, specifically targeting women 18 to 35 years of age. | 2004 | 15916999 |
| management of pre-invasive cervical cancer in low-resource setting. | cervical cancer is one of the health burdens in many developing countries. the advanced knowledge in the past decade reassured the important role of human papillomavirus as the necessary cause of cervical cancer and makes a clear understanding of its natural history. cervical cancer has a long period of pre-invasive stage, and only a small proportion of cervical intraepithelial neoplasia (cin) that can progress to be an invasive lesion. appropriate management of cin can prevent invasive cervical ... | 2004 | 21213526 |
| cost-effectiveness of cervical cancer screening strategies. | despite its low incidence in the developed world, cervical cancer is the second most common cancer among women worldwide and the third most common cause of cancer-related deaths. screening saves lives. when diagnosed and treated in the preinvasive stage, 5-year survival probabilities approach 100%. this review addresses the cost-effectiveness of the various screening strategies commonly used worldwide. the starting age of screening, interval between screens and age of women at cessation of scree ... | 2004 | 19807311 |
| proteome analysis of differential protein expression in cervical cancer cells after paclitaxel treatment. | it is well known that infection with hpv (human papillomavirus) is the main cause of cervical cancer and certain types of hpv are recognized as carcinogens. at present, there is little information regarding the antineoplastic mechanism of paclitaxel against cervical carcinoma cells. we thus tried to analyze differential protein expression and antineoplastic mechanism-related proteins after paclitaxel treatment on cervical cancer cells by using a proteomic analysis and to investigate the mechanis ... | 2004 | 20368835 |
| hpv16 semiquantitative viral load and serologic biomarkers in oral and oropharyngeal squamous cell carcinomas. | a considerable subset of oropharyngeal squamous cell carcinomas (sccs) are positive for human papillomavirus (hpv); however, delineating etiologically-associated hpv infections from sccs with concurrent hpv infection unrelated to tumorigenesis is challenging. viral load assessment in biopsy specimens may help facilitate such differentiation. hpv16 viral load and serologic markers were assessed among oral and oropharyngeal cases from a multinational study conducted by the international agency for ... | 2005 | 15688391 |
| [hpv and cancer]. | human papillomavirus (hpv) has been largely demonstrated involved in the pathogenesis of several intraepithelial lesions and cancers. the role of hpv in the carcinogenesis of intraepithelial and invasive anogenital lesions is currently well established, characterized by integrated dna hpv inside the lesions. hpv genotypes are classified according to their risk of oncogenesis and hpv16 remains the most common and higher oncogenic types. hiv-infected patients have a higher rate of hpv infection wi ... | 2005 | 15689325 |
| human papillomavirus infection in egyptian esophageal carcinoma: correlation with p53, p21, mdm2, c-erbb2 and impact on survival. | the etiological role of human papillomavirus (hpv) in esophageal carcinoma (ec) in relation to p53, mdm2, p21(waf), c-erbb2 and the overall survival (os) rate was investigated. tumor and normal tissues from 50 ec were evaluated by polymerase chain reaction and innolipa for hpv. single strand conformation polymorphism/sequencing were used to detect p53 gene mutations. immunohistochemistry was performed to determine p53, mdm2, p21(waf)and c-erbb2 expression. human papillomavirus was detected in 54 ... | 2005 | 15693850 |
| response to "primary cervical cancer screening by self-sampling of human papillomavirus dna in internal medicine outpatient clinics", by dannecker et al. (ann oncol 2004; 15: 863-869) and "histopathological validation of the sentinel node concept in cervical cancer", by barranger et al. (ann oncol 2004; 15: 870-874): dna microarrays will be instrumental in the future diagnosis of cervical dysplasia and neoplasia. | 2005 | 15695502 | |
| caspase-3-dependent apoptosis in cardiac myxoma: not associated with human papillomavirus or epstein-barr virus. | cardiac myxoma is the most common tumor of the heart, has a variable clinical presentation and immunohistochemical profile. viral infections, such as herpes simplex virus, human papillomavirus (hpv), and epstein-barr virus (ebv), may play an important role in the causes of cardiac myxoma. this investigation will demonstrate caspase-3-dependent apoptosis in cardiac myxoma without hpv or ebv infection. this study included 15 patients with cardiac myxoma, who were treated with surgical excision of ... | 2005 | 15696123 |
| re: munoz et al., "against which human papillomavirus types shall we vaccinate and screen? the international perspective." int j cancer 2004;111:278-85. | 2005 | 15704103 | |
| heterologous papillomavirus virus-like particles and human papillomavirus virus-like particle immune complexes activate human langerhans cells. | chimeric human papillomavirus virus-like particles (hpv cvlp) are currently being explored as a therapeutic vaccination strategy against cervical cancer. hpv cvlp are being explored as a result of their interaction with and activation of dendritic cells, a potent antigen-presenting cell. however langerhans cells, another type of antigen-presenting cell, can interact with hpv cvlp especially during mucosal routes of vaccine administration. langerhans cells are not activated by hpv cvlp, utilize a ... | 2005 | 15705478 |
| detection and genotyping of human papillomavirus in cervical samples from italian patients. | human papillomaviruses (hpvs) are etiological agents of cervical cancer. in order to assess the epidemiological incidence and frequency of different hpv types, we applied a polymerase chain reaction (pcr)-direct sequencing approach based on the use of my09/my11 primers as compared to hybrid capture assay. cervical samples were taken from 1,500 women, both with normal and abnormal cytological smears, and we found an incidence of 6.6% of hpv infection in brescia. overall, 97 samples tested hpv-pos ... | 2005 | 15714493 |
| human papilloma virus in oral squamous cell carcinoma in a mexican population. | to determine the human papilloma virus (hpv) infection in oral cancer and its association with smoking and drinking habits. | 2005 | 15716837 |
| targeted therapy for targeted patients: trastuzumab in adjuvant treatment of non-small-cell lung cancer. | 2005 | 15718338 | |
| cd4+ t cell immunity against the human papillomavirus-18 e6 transforming protein in healthy donors: identification of promiscuous naturally processed epitopes. | infection by 'high-risk' human papillomaviruses (hpv) is associated with the development of neoplastic lesions. hpv-18 is responsible for a very aggressive form of cancer and poor survival. as for other hpv types, immune surveillance has probably a role in the control of the infection. however, very little is known on hpv-18 immunogenicity. cd4(+) t cells from 16 healthy donors were tested ex vivo for reactivity to synthetic peptides corresponding to 3 sequences on the hpv-18 e6 transforming pro ... | 2005 | 15719368 |
| plasmacytoid dendritic cells are present in cervical carcinoma and become activated by human papillomavirus type 16 virus-like particles. | plasmacytoid dendritic cells (pdc) play an important role in the innate immune response to viral infections through the secretion of high levels of ifnalpha. we investigated whether pdc play a role in human papillomavirus (hpv) associated cervical carcinoma. | 2005 | 15721448 |
| papillomavirus infection in rural women in southern india. | to investigate the prevalence of, and the risk factors for, cervical infection with 44 types of human papillomavirus (hpv) in a rural area in the dindigul district, tamil nadu, india, we interviewed and obtained cervical cell samples from 1891 married women aged 16-59 years. hpv prevalence was 16.9% overall and 14.0% among women without cervical abnormalities, or 17.7 and 15.2%, respectively, age-standardised to the world standard population. in all, 21.9% of infections involved more than one hp ... | 2005 | 15668709 |
| association of cottontail rabbit papillomavirus e6 oncoproteins with the hdlg/sap97 tumor suppressor. | papillomaviruses are small dna viruses that infect epithelial tissues and cause warts. human papillomavirus (hpv) infection is the primary risk factor for the development of cervical cancer. the e6 and e7 oncogenes are the only genes consistently expressed in hpv-positive cervical cancer cells. cottontail rabbit papillomavirus (crpv) induces papillomas and carcinomas on cottontail and domestic rabbits and provides an excellent animal model of hpv infection and vaccine development. crpv encodes t ... | 2005 | 15669058 |
| human papillomavirus (hpv) genotyping by hpv dna chip in cervical cancer and precancerous lesions. | the human papillomavirus (hpv) is a well-known cause of cervical cancer. hpv tests are used as an adjunct test to decrease the false-negative rate of cytological screening. however, attempts are being made to replace the cytological screening with hpv tests. therefore, this study was performed to examine the possibility of using hpv tests as screening test. | 2005 | 15670301 |
| cellular process classification of human papillomavirus-16-positive siha cervical carcinoma cell using gene ontology. | this study utilized mrna differential display and the gene ontology (go) analysis to characterize the multiple interactions of a number of genes involved in human papillomavirus (hpv)-16-induced cervical carcinogenesis. we used hpv-16-positive cervical cancer cell line (siha) and normal human keratinocyte cell line (hacat) as a control. each gene has several biological functions in the go, and hence, we chosen the several functions for each gene. and then, the specific functions were correlated ... | 2005 | 15670303 |
| polymorphism in the e6 gene of human papillomavirus type 16 in the cervical tissues of korean women. | the aim of this study was to identify sequence variants in the hpv 16 e6 gene in korean women and to examine the possible association between these sequence variants and cervical cancer development. we examined the hpv 16 dna of 215 patients with no cervical disease (ncd) (n = 105) or with cervical neoplasia (n = 110) [cervical intraepithelial neoplasia (cin), n = 61; invasive cervical carcinoma (icc), n = 49] using the nested polymerase chain reaction (pcr) and pcr-directed sequencing methods. ... | 2005 | 15670304 |
| results of a phase ii double-blinded randomized clinical trial of difluoromethylornithine for cervical intraepithelial neoplasia grades 2 to 3. | our purpose was to conduct a double-blinded randomized trial of difluoromethylornithine (dfmo) at 0.125, 0.5 gm/m2, versus placebo in the treatment of cervical intraepithelial neoplasia (cin) grades 2 to 3. a promising phase i study has shown histopathologic responses at these dose levels. | 2005 | 15671570 |
| genetic abnormalities and hpv status in cervical and vulvar squamous cell carcinomas. | cervical and vulvar cancers are diseases of the female lower genital tract, and high-risk human papillomavirus (hpv) infection is the most important risk factor for the development of both cancers. however, it is clear that additional genetic events are necessary for tumor progression, particularly in hpv-negative cases. we detected the presence of high-risk hpv16 and hpv18 genomes by gene-specific polymerase chain reaction and searched for common genetic imbalances by comparative genomic hybrid ... | 2005 | 15676146 |
| modification of professional antigen-presenting cells with small interfering rna in vivo to enhance cancer vaccine potency. | rna interference using small interfering rna (sirna) is an effective means of silencing gene expression in cells. intradermal administration of nucleic acids via gene gun represents an efficient method for delivering nucleic acids to professional antigen-presenting cells in vivo. in this study, we show that the coadministration of dna vaccines encoding human papillomavirus type 16 e7 with sirna targeting key proapoptotic proteins bak and bax prolongs the lives of antigen-expressing dendritic cel ... | 2005 | 15665308 |
| immune responses to human papillomavirus in genital tract of women with cervical cancer. | to address a question whether immune responses to hpv infection play a role in control of cervical cancer, we analyzed systemic and mucosal immune responses to hpv in women who underwent radical hysterectomy for cervical cancer (hcc) or loop conization due to cervical dysplasia (loop), or had hysterectomy for other reasons (hnn). | 2005 | 15661235 |
| association of viral factors with non-familial breast cancer in taiwan by comparison with non-cancerous, fibroadenoma, and thyroid tumor tissues. | to study the etiologic factors of non-familial breast cancer, the polymerase chain reaction (pcr) and southern hybridization were used to detect six viruses including human papillomavirus (hpv), cytomegalovirus (cmv), epstein-barr virus (ebv), herpes simplex virus (hsv)-1, hsv-2, and human herpesvirus (hhv)-8 dna in 69 patients with breast cancer and 60 specimens from non-cancerous or other individuals with thyroid tumors or fibroadenoma (non-breast cancer controls). two specimens from patients ... | 2005 | 15602723 |
| polymorphism of human papillomavirus type 31 isolates infecting the genital tract of hiv-seropositive and hiv-seronegative women at risk for hiv infection. | the genomic polymorphism of high-risk human papillomavirus (hpv) for types other than 16 has not been extensively described. we describe here the genomic polymorphism of high-risk hpv type 31 in 79 women (62 hiv-seropositive, 17 hiv-seronegative) by pcr-sequencing of the long control region (lcr), e6 and e7. lcr polymorphism was generated by 25 (6.4%) single-nucleotide variations over 391 bases. each variant compared to the prototype contained from 2 to 13 variations (mean of 9.4 +/- 3.3, median ... | 2005 | 15602735 |
| impact of transforming viruses on cellular mutagenesis, genome stability, and cellular transformation. | it is estimated that 15% of all cancers are etiologically linked to viral infection. specific cancers including adult t-cell leukemia, hepatocellular carcinoma, and uterine cervical cancer are associated with infection by human t-cell leukemia virus type i, hepatitis b virus, and high-risk human papilloma virus, respectively. in these cancers, genomic instability, a hallmark of multistep cancers, has been explicitly linked to the expression of oncoproteins encoded by these viruses. this review d ... | 2005 | 15645440 |