Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| microcalorimetry: a novel method for detection of microbial contamination in platelet products. | measuring heat from replicating microorganisms in culture may be a rapid, accurate, and simple screening method for platelets (plts). microcalorimetry for detection of microorganisms in in vitro contaminated plt products was evaluated. | 2007 | 17725729 |
| combination of a new radiofrequency device and blue light for the treatment of acne vulgaris. | acne vulgaris is the most common skin disease treated by physicians. current topical and oral treatments may have short- and long-term negative consequences. since radiofrequency (rf) energy has been shown to reduce sebum production and 410-nm blue light has been shown to kill propionibacterium acnes (p. acnes) cells, these modalities in combination should be a highly effective treatment of acne vulgaris with little or no downtime or risk. this case report describes the efficacy and safety of rf ... | 2007 | 17763617 |
| microbial contamination of bm products before and after processing: a report of incidence and immediate adverse events in 257 grafts. | the incidence and potential clinical consequences of bacterial contamination of autologous and allogeneic bm products remains open to question. we report our experience of bacterial contamination of bm grafts and adverse events that occurred after transplantation. | 2007 | 17786612 |
| the impact and importance of resistance. | bacterial resistance to antibiotics began to emerge soon after their introduction. beginning in the 1970s, propionibacterium acnes also began to show decreased sensitivity to the antibiotics typically used in acne management. clinically, this trend has translated to decreased efficacy and even nonresponse to therapy. a variety of recommendations regarding optimum use of antibiotics in acne management have been developed to preserve the utility of these drugs. most important is the use of combina ... | 2007 | 17824580 |
| community-based trial results of combination clindamycin 1%--benzoyl peroxide 5% topical gel plus tretinoin microsphere gel 0.04% or 0.1% or adapalene gel 0.1% in the treatment of moderate to severe acne. | acne is characterized by different types of lesions at different stages of development. therefore, combination therapy may offer numerous advantages, including enhanced efficacy and better tolerability. the addition of benzoyl peroxide (bpo) to all long-term antibiotic treatment is widely advocated to help suppress the emergence of antibiotic-resistant bacteria. topical retinoids are recommended as early initiation treatment of most patients with acne because they target most mechanisms of acne ... | 2007 | 17824581 |
| inhibitors of dipeptidyl peptidase iv and aminopeptidase n target major pathogenetic steps in acne initiation. | acne is a chronic disease hallmarked by sebaceous hyperplasia, follicular hyperkeratosis, and inflammation. parallel targeting of these factors is required to treat acne effectively. inhibitors of dipeptidyl peptidase iv (dp iv) and aminopeptidase n (apn) show strong anti-inflammatory effects on immune cells and therapeutic efficacy in autoimmune disorders. our investigation focused on the expression and functional relevance of these ectopeptidases in three cell types which exhibit an altered ph ... | 2007 | 16778789 |
| biofilm formation by bacteria isolated from retrieved failed prosthetic hip implants in an in vitro model of hip arthroplasty antibiotic prophylaxis. | bacterial infection primarily with staphylococcus spp. and propionibacterium acnes remains a significant complication following total hip replacement. in this in vitro study, we investigated the efficacy of gentamicin loading of bone cement and pre- and postoperative administration of cefuroxime in the prevention of biofilm formation by clinical isolates. high and low initial inocula, representative of the number of bacteria that may be present at the operative site as a result of overt infectio ... | 2007 | 17001707 |
| transfer of bacteria between biomaterials surfaces in the operating room--an experimental study. | bacterial adhesion to and transfer between surfaces is a complicated process. with regard to the success of biomaterials implants, studies on bacterial adhesion and transfer should not be confined to biomaterials surfaces in the human body, but also encompass surfaces in the operating room, where the origin of many biomaterials related infections is found. the purpose of this study was to quantify the transfer of staphylococcus aureus, staphylococcus epidermidis, and propionibacterium acnes from ... | 2007 | 17058211 |
| isolation of aminopeptidase n genes of food associated propionibacteria and observation of their transcription in skim milk and acid whey. | in this study consensus oligonucleotides pn5/pn3 were designed by aligning the aminopeptidase n genes (pepn) of various actinobacteria and applied to the isolation of the pepn genes of dairy propionibacteria (pab) and closely related species associated with food. this allowed sequencing of a pepn gene region from propionibacterium jensenii lmg 16541. the sequence of this gene was completed by inverse pcr. consensus primer pairs nu1/d1 and nu2/d1 were derived from the alignment of the new sequenc ... | 2007 | 17013549 |
| incidence, microbiological findings, and clinical presentation of sternal wound infections after cardiac surgery with and without local gentamicin prophylaxis. | sternal wound infection (swi) is a serious complication after cardiac surgery. in a previous randomized controlled trial, the addition of local collagen-gentamicin in the sternal wound before wound closure was found to significantly reduce the incidence of postoperative wound infections compared with the routine intravenous prophylaxis of isoxazolyl-penicillin only. the aims of the present study were to analyse the microbiological findings of the swis from the previous trial as well as to correl ... | 2007 | 17211605 |
| effect of amodiaquine, a histamine n-methyltransferase inhibitor, on, propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice. | we examined whether treatment with amodiaquine, a potent inhibitor of histamine n-methyltransferase protects mice from propionibacterium acnes (p. acnes)-primed and lipopolysaccharide (lps)-induced hepatitis. the subcutaneous injection of amodiaquine (2 and 5 mg/kg) significantly increased the histamine levels in the liver in comparison to saline treated mice. pretreatment with amodiaquine also improved the survival rate of the hepatitis mice, and this improvement was partially associated with t ... | 2007 | 17222819 |
| role of bacterial and host factors in infectious endophthalmitis. | endophthalmitis is a frequent blinding complication of globe-penetrating injury and ocular surgery. the outcome of this intraocular infection depends both on the organism involved and management of the ensuing inflammation. the role of various toxins and bacterial factors in the pathogenesis of this infection is beginning to be delineated, but appears to be organism specific. because of the immune-privileged environment of the eye, principles important in the resolution of infection at extraocul ... | 2007 | 17264502 |
| type 1 cytokine/chemokine production by mouse nk cells following activation of their tlr/myd88-mediated pathways. | it is well established that il-18r- and toll-like receptor (tlr)-mediated signalings share a common signal pathway mediated by signal adaptor, myd88, and that il-18 synergizes with il-12 for ifn-gamma production by nk cells. here, we investigated whether tlr agonists can replace il-18 for production of ifn-gamma by nk cells. freshly isolated nk cells possessed functional lps receptor composed of tlr4/md2 complex and of cd14, and also expressed other various tlrs. hepatic cd3(-)dx5(+) nk cells pr ... | 2007 | 17289654 |
| screening of plant extracts for antimicrobial activity against bacteria and yeasts with dermatological relevance. | there is cumulative resistance against antibiotics of many bacteria. therefore, the development of new antiseptics and antimicrobial agents for the treatment of skin infections is of increasing interest. we have screened six plant extracts and isolated compounds for antimicrobial effects on bacteria and yeasts with dermatological relevance. the following plant extracts have been tested: gentiana lutea, harpagophytum procumbens, boswellia serrata (dry extracts), usnea barbata, rosmarinus officina ... | 2007 | 17291738 |
| progressive macular hypomelanosis: an overview. | progressive macular hypomelanosis (pmh) is a common skin disorder that is often misdiagnosed. various authors have written about similar skin disorders, referring to them by different names, but we believe that all these similar disorders are part of the same entity.pmh is characterized by ill-defined nummular, non-scaly hypopigmented spots on the trunk, often confluent in and around the midline, and rarely extending to the proximal extremities and neck/head region. there is no itch, pain, or pr ... | 2007 | 17298102 |
| resolution of inflammatory acne vulgaris may involve regulation of cd4+ t-cell responses to propionibacterium acnes. | propionibacterium acnes has been strongly implicated in inflammatory acne. however, its role in the disease is unclear. it has been hypothesized that an immune response to p. acnes and/or p. acnes heat shock proteins (hsps) may play a role in the pathogenesis of inflammatory acne. | 2007 | 17300234 |
| acute dehiscence of a valve prosthesis 5 years after implantation. | propionibacterium acnes, a common human skin organism [perry a.l., lambert p.a., under the microscope propionibacterium acnes, lett app microbiol 2006; 42:185-186], mostly considered a contaminant, has rarely been associated with cases of infectious endocarditis [vanagt w.y., daenen w.j., delhaas t., propionibacterium acnes endocarditis on an annuloplasty ring in an adolescent boy, heart 2004; 90:56]. we report on a 48-year old man with a history of mitral valve replacement who acutely developed ... | 2007 | 17320207 |
| deep infection after rotator cuff repair. | currently, there is little information available concerning the outcome of patients with infection after rotator cuff repair. the purpose of this study was to review retrospectively the incidence, clinical presentation, bacteriology, treatment, and outcomes of patients with rotator cuff repair complicated by deep infection. between 1975 and 2003, 39 cases of deep infection after rotator cuff repair were identified in 38 patients. at a final follow-up of 8.2 years (range, 30 months to 19.8 years) ... | 2007 | 17321157 |
| valuable lessons from sapho syndrome. | 2007 | 17347017 | |
| in vitro activity against anaerobes of retapamulin, a new topical antibiotic for treatment of skin infections. | retapamulin is the first agent of the pleuromutilin class formulated as a topical antibacterial for treating skin infections. the aim of this study was to determine the antimicrobial activity of retapamulin by determining the minimal inhibitory concentration (mic) values of this new drug and comparators against a wide range of anaerobic bacteria of human origin. | 2007 | 17350985 |
| expanding the microcomedone theory and acne therapeutics: propionibacterium acnes biofilm produces biological glue that holds corneocytes together to form plug. | the propionibacterium acnes biofilm has previously been shown to exist via genomic studies and to make a biological glue which allows for adherence to follicular walls. this gylcocalyx polymer secreted by p acnes also finds its way into sebum composition where it causes the adhesiveness of keratinocytes leading to comedones. an appreciation of p acnes biofilms and secretions has implications in immunogenicity of the organism, clinical course of acne, and therapy for comedonal and inflammatory ac ... | 2007 | 17870436 |
| propionibacterium acnes: an under-appreciated cause of post-neurosurgical infection. | propionibacterium acnes is increasingly recognized as a cause of post-neurosurgical infection. this review of patients with p. acnes neurosurgical infection was carried out in order to determine clinical characteristics and outcomes in relation to duration of antimicrobial treatment. | 2007 | 17875606 |
| direct visualization of propionibacterium acnes in prostate tissue by multicolor fluorescent in situ hybridization assay. | prostate tissues from patients with prostate cancer and benign prostatic hyperplasia (bph) frequently contain histological inflammation, and a proportion of these patients show evidence of propionibacterium acnes infection in the prostate gland. we developed a multicolor fluorescent in situ hybridization (fish) assay targeting p. acnes 23s rrna along with a 14-kb region of the p. acnes genome. this assay was used to analyze prostate tissues from patients with prostate cancer and bph. p. acnes in ... | 2007 | 17881550 |
| breast abscess bacteriologic features in the era of community-acquired methicillin-resistant staphylococcus aureus epidemics. | increasing rates of community-acquired methicillin-resistant staphylococcus aureus (mrsa) infections have also affected the microbial profile of breast abscesses. | 2007 | 17891866 |
| investigation of antibacterial activity of rosemary essential oil against propionibacterium acnes with atomic force microscopy. | in the present study, the antibacterial activity of rosemary (rosmarinus officinalis l. labiatae) essential oil against propionibacterium acnes (p. acnes) was observed with atomic force microscopy (afm). the mic (minimal inhibitory concentration) value of rosemary essential oil against p.acnes was 0.56 mg/ml. significant changes in morphology and size of p. acnes were observed by atomic force microscopy (afm) in response to essential oil treatment. the essential oil first attached to the surface ... | 2007 | 17893831 |
| the c/ebp beta isoform 34-kda lap is responsible for nf-il-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing. | the c/ebpb gene is translated into three different protein isoforms, two transcriptional activating proteins (38-kda full and 34-kda liver-enriched transcriptional activation protein (lap)) and one transcriptional inhibitory protein, by alternative use of different aug initiation codons within the same open reading frame. the isoform 34-kda lap is thought to be the most transcriptionally active form of c/ebpbeta in macrophages. to assess the function of the 34-kda lap in vivo, we generated knock ... | 2007 | 17911624 |
| successful vaccination against leishmania chagasi infection in balb/c mice with freeze-thawed leishmania antigen and corynebacterium parvum. | this study evaluated the potential of a leishmania antigen vaccine in protecting balb/c mice against leishmania chagasi. mice received two subcutaneous doses of l. amazonensis vaccine with corynebacterium parvum and subsequent boost was done without adjuvant. one week later, mice were challenged with l. chagasi. we observed that this vaccine caused a significant reduction in parasite load in liver and spleen and induced a high production of ifn-gamma and il-4 by spleen cells from vaccinated mice ... | 2007 | 17919443 |
| activity of the novel macrolide bal19403 against ribosomes from erythromycin-resistant propionibacterium acnes. | bal19403 is a macrolide antibiotic from a novel structural class with potent activity against propionibacteria in vitro. the antibacterial spectrum of bal19403 covers clinical isolates with mutations in the 2057 to 2059 region of 23s rrna that confer resistance to erythromycin and clindamycin. the basis of this improved activity was investigated by ribosome binding assays and by a coupled transcription and translation assay. the latter was specifically developed for the use of ribosomes from pro ... | 2007 | 17923495 |
| topical clindamycin in the management of acne vulgaris. | a small cadre of antimicrobials are commonly used and regarded as effective and safe, as systemic and topical treatments of acne vulgaris. these include oral tetracycline, doxycycline, minocycline and topical clindamycin and erythromycin. topical antimicrobials work via both antimicrobial and non-antimicrobial mechanisms: the former due to suppression of the growth of propionibacterial species (especially propionibacterium acnes and p. granulosum). clindamycin appears to be superior in efficacy ... | 2007 | 17931096 |
| wound contamination in cardiac surgery. a systematic quantitative and qualitative study of the bacterial growth in sternal wounds in cardiac surgery patients. | to investigate the degree of bacterial contamination in the sternal wound during cardiac surgery and the sternal skin flora after operation in order to increase our understanding of the pathogenesis of sternal wound infections. | 2007 | 17931237 |
| common and alternate oral antibiotic therapies for acne vulgaris: a review. | acne vulgaris is an extremely common disorder affecting many adolescents and adults throughout their lifetimes. the pathogenesis of acne is multifactorial and is thought to involve excess sebum, follicular hyperkeratinization, bacterial colonization, and inflammation. many therapeutic options exist for treating acne, including topical benzoyl peroxide, topical and oral antibiotics, topical and oral retinoids, and oral contraceptives. oral antibiotics have been a mainstay in the treatment of acne ... | 2007 | 17941358 |
| relation between mental stress-induced prefrontal cortex activity and skin conditions: a near-infrared spectroscopy study. | although psychological stress affects skin condition, the neurophysiological mechanism involved is unclear. in this study, we evaluated the relationship between skin condition and left/right asymmetry in prefrontal cortex (pfc) activity during mental stress tasks since recent studies have suggested that the right pfc dominates the regulation of the stress response system, including the hypothalamic-pituitary-adrenal (hpa) axis. using near-infrared spectroscopy, we measured hemoglobin concentrati ... | 2007 | 17950258 |
| zinc salts inhibit in vitro toll-like receptor 2 surface expression by keratinocytes. | propionibacterium acnes (p. acnes) plays an important role in the induction and maintenance of the inflammatory phase of acne. at the therapeutic level, it has been shown that zinc salts could have a beneficial effect on mild and moderate inflammatory acne lesions. however, their mechanisms of action are still only partially known. immediate early immune response is a crucial route in the development of inflammatory reaction and, specifically, activation of toll-like receptors (tlrs) leading to ... | 2007 | 17951128 |
| antibiotics for the eradication of propionibacterium acnes biofilms in surgical infection. | propionibacterium acnes is increasingly recognized as a cause of delayed infection after spinal instrumentation or shunting for hydrocephalus. biofilm development by this organism has recently been demonstrated. we therefore investigated the effect of two different courses of three antibiotics (penicillin, rifampicin and linezolid) on mature p. acnes biofilms in vitro. outcomes were eradication or regrowth after withdrawal of antibiotics, simulating successful treatment and relapse. | 2007 | 17959732 |
| in vitro activity of kaempferol isolated from the impatiens balsamina alone and in combination with erythromycin or clindamycin against propionibacterium acnes. | the in vitro antibacterial activity against antibiotic-resistant propionibacterium acnes of kaempferol isolated from the impatiens balsamina alone and in combination with erythromycin or clindamycin antibiotics was investigated. the antibiotic combination effect against antibiotic-resistant p. acnes was studied by checkerboard test. kaempferol and quercetin demonstrated antibacterial activities against p. acnes. minimum inhibitory concentrations (mics) for both compounds were < or =32 ug/ml and ... | 2007 | 17978809 |
| [co-occurence of indol-producing bacterial strains in the vagina of women infected with chlamydia trachomatis]. | the aim of this study was to determine if cervicitis, caused by chlamydia trachomatis (c. trachomatis), has an influence on the frequency of occurrence of selected aerobic and anaerobic bacterial strains, connected with etiology of aerobic vaginitis (av) and bacterial vaginosis (bv). indole-producing bacteria have received particular attention due to their possibly inductive role in chronic cervicitis caused by c. trachomatis. | 2007 | 18050609 |
| aortitis following percutaneous aortic side branch embolization prior to endovascular repair of infrarenal aortic aneurysm. | to report two cases of life-threatening aortic infection after percutaneous endovascular coil embolization prior to endovascular abdominal aortic aneurysm (aaa) repair (evar). | 2007 | 18052597 |
| infections after endovascular coil embolization. | 2007 | 18052598 | |
| critical role for cxc chemokine ligand 16 (sr-psox) in th1 response mediated by nkt cells. | the transmembrane chemokine cxcl 16 (cxcl16), which is the same molecule as the scavenger receptor that binds phosphatidylserine and oxidized lipoprotein (sr-psox), has been shown to mediate chemotaxis and adhesion of cxc chemokine receptor 6-expressing cells such as nkt and activated th1 cells. we generated sr-psox/cxcl16-deficient mice and examined the role of this chemokine in vivo. the mutant mice showed a reduced number of liver nkt cells, and decreased production of ifn-gamma and il-4 by a ... | 2007 | 18056360 |
| linoleic acid isomerase from propionibacterium acnes: purification, characterization, molecular cloning, and heterologous expression. | propionibacterium acnes strain atcc 6919 catalyzes the isomerization of the double bond at the c9 position in linoleic acid (c9,c12, 18:2) to form t10,c12 conjugated linoleic acid (cla, 18:2). cla has significant health benefits in animal and human. the linoleic acid c9 isomerase was purified to an apparent homogeneity by successive chromatography on diethylaminoethyl (deae) anion exchange, hydrophobic interaction, and chromatofocusing columns. two degenerated oligonucleotide primers were synthe ... | 2007 | 18057448 |
| sarcoidosis-like reaction related to propionibacterium acnes and immune restoration syndrome in hiv infection . | propionibacterium acnes is thought to be a potential triggering agent of sarcoidosis. we describe a woman who developed chronic meningitis with sarcoid-like multisystemic involvement under treatment for human immunodeficiency virus infection. p. acnes was isolated from cerebrospinal fluid. we assume that p. acnes might have triggered this sarcoid-like reaction with meningitis, as a consequence of an immune reconstitution. | 2007 | 18061967 |
| temporal changes in sebum excretion and propionibacterial colonization in preadolescent children with and without acne. | it is generally accepted that the onset of sebum secretion occurs before puberty in boys and girls as a result of increasing androgen output during the adrenarche. propionibacteria are part of the commensal skin flora and, in adults, are found in highest numbers in sebum-rich areas of skin such as the face and upper trunk. previous studies investigating the association between sebum output and propionibacterial population densities have been cross-sectional and have been carried out mainly in ad ... | 2007 | 17199562 |
| antibiotics concentrations in a patient with postoperative endophthalmitis. | we report a case of endophthalmitis who underwent a vitreous biopsy to assess sensitivity and to inject broad-spectrum intraocular antibiotics. minimal inhibitory concentration (mic) values of antibiotics against a coagulase-negative staphylococcus and proprionibacterium acnes were also assessed. | 2007 | 18025662 |
| anti-microbial and -inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris. | lipids are important constituents of the human epidermis. either free and organized into broad lipid bilayers in the intercorneocytes spaces, or covalently bound to the corneocyte envelope, they play a crucial role in permeability barrier function and are major contributors to cutaneous anti-microbial defense. free sphingoid bases are a recent addition to this family of active lipids, which emerged from studies of breakdown products from ceramides. phytosphingosine (ps) is a lipid occurring natu ... | 2007 | 18489348 |
| acne is not associated with yet-uncultured bacteria. | current clinical and microbiological information on acne fails to demonstrate a clear association between particular species, including propionibacterium acnes, and disease, and the disease continues to be a considerable problem. to test if acne is associated with hitherto uncultured bacteria residing in diseased skin follicles, sequencing and phylogenetic analysis of approximately 5,700 amplified and cloned 16s rrna genes were used to determine the microbial diversity in follicles from acne pat ... | 2008 | 18716234 |
| propionibacterium acnes stimulates pro-matrix metalloproteinase-2 expression through tumor necrosis factor-alpha in human dermal fibroblasts. | propionibacterium acnes (p. acnes) is a commensal microorganism found in sebum-rich skin and plays a role in acne inflammation by stimulating keratinocyte to produce a number of proinflammatory cytokines. however, the role of p. acnes in the dermis of acne lesions, where tissue remodeling after inflammation eventually takes place, is not known. in this study, we investigated whether p. acnes induces matrix metalloproteinase (mmp), a key enzyme involved in matrix remodeling in human dermal fibrob ... | 2008 | 18049448 |
| novel endo-alpha-n-acetylgalactosaminidases with broader substrate specificity. | in an effort to identify novel endo-alpha-n-acetylgalactosaminidases (endo-alpha-galnacases), four potential genes were cloned. three of the expressed proteins engef from enterococcus faecalis, engpa from propionibacterium acnes, and engcp from clostridium perfringens were purified and characterized. their substrate specificity was investigated and compared to the commercially available endo-alpha-galnacases from streptococcus pneumoniae (engsp) and alcaligenes sp. (engal). all enzymes were incu ... | 2008 | 18635885 |
| influence of 16s rdna primer sequence mismatches on the spectrum of bacterial genera detected in prostate tissue by universal eubacterial pcr. | propionibacterium sp. and staphylococcus spp. are the most frequent bacteria cultured from prostatectomy specimens but are seldom detected by universal eubacterial pcr. | 2008 | 18651564 |
| an evaluation of pcr primer sets used for detection of propionibacterium acnes in prostate tissue samples. | multiple studies have now shown that propionibacterium acnes can be cultured from post-prostatectomy derived prostate tissue samples. in contrast, both universal eubacterial 16s rdna pcr and p. acnes-specific 16s rdna pcr have failed to detect this organism at a frequency similar to that of bacterial culture. a potential explanation for this discrepancy, proposed by cohen et al., involves mismatches in 16s rdna primer sets used for bacterial detection. | 2008 | 18651578 |
| bioengineering a humanized acne microenvironment model: proteomics analysis of host responses to propionibacterium acnes infection in vivo. | acne is a human disease of the sebaceous hair follicle. unlike humans, most animals produce little or no triglycerides in hair follicles to harbor propionibacterium acnes a fact that has encumbered the development of novel treatments for acne lesions. although genetic mutant mice with acne-like skins have been used for screening anti-acne drugs, the mice generally have deficits in immune system that turns out to be inappropriate to generate antibodies for developing acne vaccines. here, we emplo ... | 2008 | 18651708 |
| biochemistry of pufa double bond isomerases producing conjugated linoleic acid. | the biotransformation of linoleic acid (la) into conjugated linoleic acid (cla) by microorganisms is a potentially useful industrial process. in most cases, however, the identities of proteins involved and the details of enzymatic activity regulation are far from clear. here we summarize available data on the reaction mechanisms of cla-producing enzymes characterized until now, from butyrivibrio fibrisolvens, lactobacillus acidophilus, ptilota filicina, and propionibacterium acnes. a general fea ... | 2008 | 18655062 |
| preoperative disinfection of the conjunctival sac with antibiotics and iodine compounds: a prospective randomized multicenter study. | to compare disinfection by povidone-iodine (pi) solution with that by polyvinyl alcohol-iodine (pai) solution in preoperative eyewash and to assess the optimal duration of the preoperative application of 0.5% levofloxacin (lvfx) ophthalmic solution. | 2008 | 18661264 |
| cbt-sl5, a bacteriocin from enterococcus faecalis, suppresses the expression of interleukin-8 induced by propionibacterium acnes in cultured human keratinocytes. | propionibacterium acnes is known to play a pivotal role in the pathogenesis of acne vulgaris. cbt-sl5 is one of the antimicrobial peptides from enterococcus faecalis sl5, and it has shown antimicrobial activity against p. acnes. the aim of this study was to investigate the anti-inflammatory effect of cbt-sl5 on the inflammation induced by p. acnes in cultured human keratinocyes. cultured human keratinocytes derived from neonatal foreskin were treated with heatkilled p. acnes to induce inflammati ... | 2008 | 18667861 |
| bacteriologic profile of the conjunctiva in the patients with dry eye. | to assess the conjunctival bacterial profiles in dry eye and their fluoroquinolone susceptibility patterns. | 2008 | 18672220 |
| monitoring the physiologic stress response: a novel biophysical approach for the rapid detection of bacteria in platelet concentrate. | currently approved culture-based methods for the bacterial testing of platelet concentrates (pcs) require an extended period of time to obtain results. a new approach based on the monitoring of the bacterial response to physiologic stress is presented. because the stress response is independent of the growth rate, decisive results can be obtained in near real time. | 2008 | 18673343 |
| value of anaerobic culture in bacterial surveillance program for platelet concentrates. | short-term aerobic bacterial culture (stabc) has been used routinely in hong kong since 1998 to reduce bacterial contamination in platelet concentrates (pcs) with good results. with more countries implementing routine aerobic and anaerobic cultures of pcs, a prospective study was conducted to determine the value of anaerobic culture to stabc. | 2008 | 18694462 |
| inducible siphoviruses in superficial and deep tissue isolates of propionibacterium acnes. | propionibacterium acnes is a commensal of human skin but is also known to be involved in certain diseases, such as acne vulgaris and infections of orthopaedic implants. treatment of these conditions is complicated by increased resistance to antibiotics and/or biofilm formation of p. acnes bacteria. p. acnes can be infected by bacteriophages, but until recently little has been known about these viruses. the aim of this study was to identify and characterize inducible phages from p. acnes on a gen ... | 2008 | 18702830 |
| antibacterial and anti-inflammatory effects of jeju medicinal plants against acne-inducing bacteria. | propionibacterium acnes and staphylococcus epidermidis are pus-forming bacteria that trigger inflammation in acne. the present study was conducted to evaluate the antimicrobial activities of jeju medicinal plants against these etiologic agents of acne vulgaris. ethanol extracts of jeju plants were tested for antimicrobial activities by disc diffusion and broth dilution methods. the results from the disc diffusion assays revealed that four medicinal plants, mollugo pentaphylla, angelica anomala, ... | 2008 | 18497484 |
| the significance of t cells, b cells, antibodies and macrophages against encephalomyocarditis (emc)-d virus-induced diabetes in mice. | in order to clarify the significance of protective mechanisms against encephalomyocarditis (emc) virus-induced diabetes in mice, we studied the relative importance of t cells, b cells, antibodies and macrophages in the prevention of virus-induced diabetes. neither t cell-deficient athymic nude mice nor b cell-deficient micromt/micromt mice showed an enhanced clinical course of emc-d virus-induced diabetes, indicating that neither t cells nor b cells played a major role in the protection against ... | 2008 | 18500429 |
| ribosomal rna-based analysis of the bacterial flora from the conjunctivae of cattle with bovine keratoconjunctivitis (bkc). | bovine keratoconjunctivitis (bkc), colloquially referred to as 'pinkeye', is a disease affecting cattle worldwide; it costs cattle producers millions of dollars in economic loss annually. while moraxella spp. are the primary etiologic agent of pinkeye, surveys of flora from the conjunctivae of livestock from around the world have indicated that a variety of bacterial commensals occupy this niche. we used molecular biology-based methods to determine the composition of bacterial flora in the conju ... | 2008 | 18513895 |
| in vitro evaluation of the effect of nicotine, cotinine, and caffeine on oral microorganisms. | the aim of this in vitro study was to evaluate the effects of nicotine, cotinine, and caffeine on the viability of some oral bacterial species. it also evaluated the ability of these bacteria to metabolize those substances. single-species biofilms of streptococcus gordonii, porphyromonas gingivalis, or fusobacterium nucleatum and dual-species biofilms of s. gordonii -- f. nucleatum and f. nucleatum -- p. gingivalis were grown on hydroxyapatite discs. seven species were studied as planktonic cell ... | 2008 | 18535638 |
| characterization of the immune response in the synovitis, acne, pustulosis, hyperostosis, osteitis (sapho) syndrome. | the aetiology of sapho (synovitis, acne, palmoplantar pustulosis, hyperostosis, osteitis) syndrome seems to involve genetic, infectious and immunological components. we examined innate and adaptive immune responses in sapho syndrome, as compared with psa and ra. we also studied the effect of etanercept on immunological parameters. | 2008 | 18559374 |
| benzoyl peroxide microsphere cream as monotherapy and combination treatment of acne. | this office-based case series describes the use of a new formulation of benzoyl peroxide (bpo) delivered via a porous microsphere cream vehicle in patients with mild to moderate acne vulgaris. while bpo has been used for many years as antimicrobial in the treatment of acne, in recent years its use has been increasingly encouraged as part of a strategy designed to reduce propionibacterium acnes (p acnes) resistance to antibiotics. historically, a major drawback to bpo treatment has been irritatio ... | 2008 | 18561594 |
| all-trans retinoic acid shifts propionibacterium acnes-induced matrix degradation expression profile toward matrix preservation in human monocytes. | propionibacterium acnes is a critical component in the pathogenesis of acne vulgaris, stimulating the production of various inflammatory mediators, such as cytokines and chemokines, important in the local inflammatory response found in acne. this study explored the role of p. acnes and its ability to induce matrix metalloproteinases (mmps) in primary human monocytes and how this induction is regulated by retinoids. mmp-1- and mmp-9-expressing cells were present in perifollicular and dermal infla ... | 2008 | 18563181 |
| role of infectious agents in systemic rheumatic diseases. | the relationship between infection and autoimmunity has been increasingly defined over the last twenty years or so. it is now quite clear that, in genetically susceptible individuals, environmental factors (mainly infections) play a critical role in the pathogenesis of autoimmune diseases. it is believed that infections contribute to the maturation of the immune system from the innate to adoptive phases, and that bacterial and viral infections are arthritogenic stimulants leading to various rheu ... | 2008 | 18570751 |
| effects of er:yag laser irradiation on biofilm-forming bacteria associated with endodontic pathogens in vitro. | with the development of dental laser delivery systems that can enter into the root canals, it is possible to use er:yag lasers to remove the residual biofilm associated with infected root canals. we examined their effects against biofilms made of actinomyces naeslundii, enterococcus faecalis, lactobacillus casei, propionibacterium acnes, fusobacterium nucleatum, porphyromonas gingivalis, or prevotella nigrescens in vitro. after er:yag laser irradiation with energy densities ranging between 0.38- ... | 2008 | 18570988 |
| topical taurine bromamine, a new candidate in the treatment of moderate inflammatory acne vulgaris: a pilot study. | taurine bromamine (taubr), the product of taurine and hypobromous acid (hobr), exerts anti-inflammatory and antibacterial properties. recently we have shown that propionibacterium acnes, a potential pathogenic agent of acne, is extremely sensitive to taubr. as topical antibiotics are associated with the emergence of resistant bacteria, taubr seems to be a good candidate for topical therapy for acne vulgaris. in our double blind investigation, the efficacy and safety of 3.5 mm taubr cream was eva ... | 2008 | 18573718 |
| azithromycin pulses in the treatment of inflammatory and pustular acne: efficacy, tolerability and safety. | azithromycin is an azalide analogous to erythromycin; it has an anti-inflammatory action that prevents the growth of propionibacterium acnes, a major microorganism involved in the pathogenesis of inflammatory acne. | 2008 | 18608737 |
| primary intraocular lymphoma: another great masquerader. | to describe diverse and atypical presentations of the most common masquerader in neoplastic masquerade syndromes. | 2008 | 18609476 |
| similar to acne vulgaris, bacteria may produce the biological glue that causes plugging of the meibomian gland leading to chalazions. | 2008 | 18412605 | |
| infection associated with hematoma formation after shoulder arthroplasty. | hematoma formation requiring operative treatment after shoulder arthroplasty may be associated with higher patient morbidity. we therefore determined whether there was an association of hematoma formation requiring operative treatment with deep infection after shoulder arthroplasty. between 1978 and 2006, we performed 4147 shoulder arthroplasties in 3643 patients. of these, 12 shoulders (0.3%) underwent reoperation for hematoma formation. the mean time interval from arthroplasty to surgery for t ... | 2008 | 18421541 |
| [is acne caused by colonization with the "wrong" strain of propionibacterium acnes? a review of the role of propionibacterium acnes in acne]. | acne is still a major problem, and treatment options are far from ideal. a number of studies suggest that the species propionibacterium acnes plays an important role in the pathogenesis, and new data point towards molecular mechanisms by which the organism is able to trigger the host inflammatory response. the current knowledge on p. acnes in relation to acne is reviewed. | 2008 | 18433578 |
| a microbiological profile of symptomatic teeth with primary endodontic infections. | the aim of this study was to evaluate the composition of the microbiota of primary endodontic infections associated with symptomatic teeth. samples were collected by means of a #15 h-type file and 2 sterile paper points from 60 symptomatic (n = 30) or asymptomatic (n = 30) single-rooted teeth with necrotic pulp. the presence of 40 bacterial species was determined by the checkerboard dna-dna hybridization method. the species found in higher counts (x10(5)) in symptomatic cases were fusobacterium ... | 2008 | 18436031 |
| cerebrospinal fluid shunt infections in children over a 13-year period: anaerobic cultures and comparison of clinical signs of infection with propionibacterium acnes and with other bacteria. | shunt infections represent a major problem with risk for sequelae and even death. the aim in this retrospective study was to analyze the incidence, origin, and clinical presentation of shunt infections, with special reference to the results of cultures for anaerobic organisms performed in addition to the usual tests, to prolonged incubation times, and to infections caused by propionibacterium acnes. | 2008 | 18447670 |
| gefitinib-associated propionibacterium acnes pleural empyema. | 2008 | 18449014 | |
| minocycline for the treatment of sarcoidosis: is the mechanism of action immunomodulating or antimicrobial effect? | a 47-year-old female was diagnosed to have pulmonary, ocular, and nodular-type muscular sarcoidosis. seven years later, nodules developed in all limb muscles. she received minocycline 200 mg daily, which resulted in an obvious reduction of the muscular sarcoidosis with a significant decrease in the serum angiotensin-converting enzyme level. nine months later, the minocycline was discontinued, thus resulting in a rapid recurrence of the disease. the immediate readministration of minocycline again ... | 2008 | 18458989 |
| propionibacterium acnes postoperative shoulder arthritis: an emerging clinical entity. | the purpose of this study, which involved 276 patients, was to report the importance of propionibacterium acnes in shoulder infections. the proportion of patients with shoulder infection who had infection due to p. acnes was significantly greater than the proportion of patients with lower limb infection who had infection due to p. acnes (9 of 16 patients vs. 1 of 233 patients; p < .001). this bacterium requires a prolonged incubation period and should not be considered to be a contaminant. | 2008 | 18462110 |
| antibodies elicited by inactivated propionibacterium acnes-based vaccines exert protective immunity and attenuate the il-8 production in human sebocytes: relevance to therapy for acne vulgaris. | propionibacterium acnes is a key pathogen involved in the progression of inflammation in acne vulgaris. we examined whether vaccination against p. acnes suppressed p. acnes-induced skin inflammation. inactivation of p. acnes with heat was employed to create a p. acnes-based vaccine. intranasal immunization in mice with this inactivated vaccine provoked specific antibodies against p. acnes. most notably, immunization with inactivated vaccines generated in vivo protective immunity against p. acnes ... | 2008 | 18463682 |
| labdane-type diterpenes active against acne from pine cones (pinus densiflora). | bioassay-guided extraction and fractionation of the aqueous methanolic extract of the cones of pinus densiflora (pinaceae) afforded one new labdane-type diterpene aldehyde, 15-nor-14-oxolabda-8(17),12 e-diene-18-oic acid, along with eight known diterpenes. their structures were elucidated using spectroscopic methods as well as by comparison with previously reported data. the isolates showed antibacterial (propionibacterium acnes) and antifungal activities. | 2008 | 18484541 |
| characteristics and treatment outcome of cerebrospinal fluid shunt-associated infections in adults: a retrospective analysis over an 11-year period. | data on infections associated with cerebrospinal fluid (csf) shunts among adults are limited. therefore, we performed a retrospective study of shunt-associated infections in adults. | 2008 | 18484878 |
| [acne. current pathophysiologic considerations]. | seborrhea, follicular hyperkeratosis, propionibacteria, and inflammatory reactions are the most important factors leading to acne. the combination of increased sebum producation and follicular hyperkeratosis facilitates an increased growth of propionibacterium acnes. its metabolic products lead to follicular inflammation and, in extreme cases, even to perifollicular abscesses. sebum production is influenced by androgens, so that abnormalities in androgen levels can produce seborrhea and acne. fo ... | 2008 | 18488182 |
| inflammation and prostate cancer: a focus on infections. | despite accumulating evidence that inflammation may affect the development of prostate cancer, responsible causes of intraprostatic inflammation remain elusive. this review presents epidemiologic literature on infections, particularly sexually transmitted and other ascending urogenital infections, as possible causes of intraprostatic inflammation and/or prostate cancer. study results are interpreted in light of the inflammatory and carcinogenic potential of each infectious agent, as well as the ... | 2008 | 18765120 |
| biofilms in skin infections: propionibacterium acnes and acne vulgaris. | it is generally accepted that many human infections are biofilm-related and that sessile (biofilm-grown) cells are highly resistant against antimicrobial agents. propionibacterium acnes plays a role in the pathogenesis of acne vulgaris, a common disorder of the pilosebaceous follicles and it has been suggested that p. acnes cells residing within the follicles grow as a biofilm. although p. acnes biofilms have not been observed directly in the pilosebaceous unit, the observation that p. acnes rea ... | 2008 | 18782032 |
| vaccine therapy for p. acnes-associated diseases. | recent studies have afforded abundant evidences showing that propionibacterium acnes (p. acnes) is involved not only in acne vulgaris, but also in many diseases, including endocarditis, endophthalmitis, osteomyelitis, joint, nervous system, cranial neurosurgery infections, and implanted biomaterial contamination. in spite of a range of p. acnes pathogenicity, its vaccine therapies have been studied much less intensively than antibiotic therapies which have been mainstay of treatment for p. acnes ... | 2008 | 18782033 |
| acne vaccines: therapeutic option for the treatment of acne vulgaris? | acne, one of the most common skin diseases, is caused by multiple factors, including propionibacterium acnes. studies suggest that responses to p. acnes by host immunity play important roles in its pathogenesis. identifying immune modulators that attenuate inflammatory responses against p. acnes and the inhibition of bacterial growth may lead to novel avenues of immunologic intervention. | 2008 | 18787542 |
| an assessment of the efficacy of blue light phototherapy in the treatment of acne vulgaris. | acne vulgaris is a common skin condition that affects 8 out of 10 people. it varies from mild to severe, and different treatments target various aspects of the disease. propionibacterium acnes, one of the culprits involved in the pathogenesis of acne vulgaris, is the main target of all major medical treatments used. studies conducted in recent years have shown favorable effects within the visible light spectrum for the treatment of acne vulgaris. | 2008 | 18789052 |
| bone marrow-derived immune cells mediate sensitization to liver injury in a myeloid differentiation factor 88-dependent fashion. | toll-like receptors (tlrs) expressed on both immune cells and hepatocytes recognize microbial danger signals and regulate immune responses. previous studies showed that tlr9 and tlr2 mediate propionibacterium acnes-induced sensitization to lipopolysaccharide-triggered acute liver injury in mice. ligand-specific activation of tlr2 and tlr9 are dependent on the common tlr adaptor, myeloid differentiation factor 88 (myd88). here, we dissected the role of myd88 in parenchymal and bone marrow (bm)-de ... | 2008 | 18798338 |
| air-borne microbial contamination of surfaces in a uk dental clinic. | little is known about the number, type, or antibiotic resistance profiles, of air-borne microbes present in hospital settings yet such information is important in designing effective measures to reduce cross-infection. in this study settle plates were used to identify and quantify the air-borne microbes present in a dental clinic. all isolates were identified to species level using partial 16s ribosomal rna gene sequencing and their susceptibility to ampicillin, chloramphenicol, erythromycin, ge ... | 2008 | 18802318 |
| non-invasive diagnostic evaluation of phototherapeutic effects of red light phototherapy of acne vulgaris. | during the past few years, various phototherapeutic protocols with full-spectrum visible light or selected wavebands have been investigated in the treatment of acne vulgaris with variable results. | 2008 | 18811865 |
| a case of polymicrobial keratitis violating an intact lens capsule. | to report a case of polymicrobial keratitis resistant to topical and intraocular antibiotics with recurrence after penetrating keratoplasty. | 2008 | 18812771 |
| selection of serotype-specific vaccine candidate genes in actinobacillus pleuropneumoniae and heterologous immunization with propionibacterium acnes. | actinobacillus pleuropneumoniae (a. pleuropneumoniae) is a highly contagious lethal causative agent of swine pleuropneumoniae. vaccines for this disease are usually serotype specific. in order to identify immunogenic genes specific to serotypes, two differentially expressed gene cdna libraries of a. pleuropneumoniae ccvc259 (serotype 1) and ccvc263 (serotype 5) had been constructed by using a cdna representational difference analysis (cdna-rda). from the libraries, six potential vaccine candidat ... | 2008 | 18835316 |
| biological activities of korean citrus obovoides and citrus natsudaidai essential oils against acne-inducing bacteria. | this study was designed to analyze the chemical composition of citrus obovoides (geumgamja) and citrus natsudaidai (cheonyahagyul) oils and to test their biological activities. these citrus essential oils were obtained by steam distillation of fruits collected from jeju island, korea, and were analyzed using gas chromatograph (gc)-flame ionization detectors (fid) and gc-ms. limonene and gamma-terpinene were the major components of the two citrus species. to evaluate in vitro anti-acne activity, ... | 2008 | 18838824 |
| [postoperative intra-abdominal abscess with bacteremia due to propionibacterium acnes]. | 2008 | 18842245 | |
| [propionibacterium acnes endocarditis on an aortic prosthesis in a patient carrying a pacemaker]. | 2008 | 18842370 | |
| assessment of the bacterial diversity of human colostrum and screening of staphylococcal and enterococcal populations for potential virulence factors. | in contrast to breast milk, little is known about the bacterial composition of human colostrum. the objective of this work was to analyze the bacterial diversity of colostrum obtained from healthy women and to characterize the dominant bacterial species for the presence of possible virulence factors. samples of colostrum obtained from 36 healthy women were inoculated into different culture media. several isolates from each medium were selected and identified. staphylococcal and enterococcal isol ... | 2008 | 18845249 |
| antibiotic use in acne vulgaris and rosacea: clinical considerations and resistance issues of significance to dermatologists. | antibiotics are commonly prescribed in dermatology practice for a variety of disorders, including acne vulgaris and rosacea. importantly, they often are used long-term for these inflammatory dermatoses. changes in bacterial ecology related to antibiotic prescribing have led to the decreased sensitivity of some bacterial organisms, such as propionibacterium acnes, to antibiotics commonly prescribed by dermatologists. the potential clinical outcomes of altered bacterial sensitivities may vary amon ... | 2008 | 18924545 |
| generation of human monoclonal antibodies against propionibacterium acnes by applying the phage display method to human peripheral blood mononuclear cells immunized in vitro. | propionibacterium acnes is a gram-positive, non-spore-forming, rod-shaped bacterium that is often detected in normal human skin flora. p. acnes has been associated with many diseases. in this study, we attempted to generate anti-p. acnes human monoclonal antibodies. a phage antibody library was first generated from human peripheral blood mononuclear cells immunized in vitro with p. acnes using the phage display method, and p. acnes-specific phage antibodies were obtained using solid phase pannin ... | 2008 | 19003162 |
| modulation of the type i hypersensitivity late phase reaction to ova by propionibacterium acnes-soluble polysaccharide. | late phase reaction (lpr) of immediate hypersensitivity is a th2 response characterized by eosinophil recruitment and related to allergic asthma pathogenesis. several strategies were developed trying to control the tissue damage observed in this reaction. recently, we verified that killed propionibacterium acnes (p. acnes), a gram-positive bacillus, immunomodulated lpr in a murine model, potentiating or suppressing it depending on the treatment protocol used. however, the bacterium compounds res ... | 2008 | 19014971 |
| bacterial contamination of surgeons gloves during shunt insertion: a pilot study. | bacterial infection is a major cause of shunt dysfunction. it is well-known that the majority of pathogenic micro-organisms are low-virulent bacteria normally found on intact skin. probably shunts become contaminated during surgery either by contact to the patient skin, or contact from contaminated gloves or instruments. this study was performed to find out to what extent gloves become contaminated during shunt surgery. gloves used during shunt implantation were examined in 10 operations. shunt ... | 2008 | 19016119 |
| antimicrobial activity of iodoquinol 1%-hydrocortisone acetate 2% gel against ciclopirox and clotrimazole. | commercially available topical formulations consisting of iodoquinol 1%-hydrocortisone acetate 2%, ciclopirox 0.77%, and clotrimazole 1%-betamethasone dipropionate 0.5% were assessed for their antimicrobial activity against cultures of micrococcus luteus, propionibacterium acnes, methicillin-resistant staphylococcus aureus (mrsa), pseudomonas aeruginosa, corynebacterium aquaticum, trichophyton mentagrophytes, malassezia furfur, microsporum canis, candida albicans, trichophyton rubrum, or epiderm ... | 2008 | 19055171 |