Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| daily variation in concentration of plasma corticosteroid in hypophysectomized rats. | a daily variation in the concentration of plasma corticosteroid hormone is present in hypophysectomized rats implanted with pellets of adrenocorticotropic hormone (acth) and thyroxine. although acth is necessary to maintain a functional adrenal, and thyroxine is required to permit the expression of the plasma corticosteroid rhythm, a normal daily variation in plasma corticosteroid concentration does not appear to depend on the periodic release of pituitary hormones. | 1976 | 179796 |
| nitrogenase of azotobacter chroococcum. kinetics of the reduction of oxidized iron-protein by sodium dithionite. | the kinetics of the reduction of oxidized fe-protein of nitrogenase from azotobacter chroococcum by sodium dithionite were studied by stopped-flow and rapid-freezing e.p.r. (electron-paramagnetic-resonance) spectroscopy. the appearance of the gav. = 1.94 e.p.r. signal (0.24 electron integrated intensity/mol) was associated with a one-electron reduction by so2--with k greater than 10(8)m-1-s-1 at 23 degrees c. a value of k = 1.75s-1 was obtained for the rate of dissociation of s2o42- into 2so2-- ... | 1976 | 180978 |
| properties and regulation of liver phosphorylase phosphatase. | 1976 | 184701 | |
| urea, a specific inhibitor of catabolite sensitive operons. | 1976 | 184780 | |
| sv40 and adenovirus early functions involved in dna replication and transformation. | 1976 | 184845 | |
| the secretion of lysosomal enzymes. | the studies reviewed in this chapter provide further evidence that the secretion of lysosomal enzymes and other hydrolases is a constitutive function of certain cells whereas in other cells is an inducible process probably contributing to the pathology of a variety of diseases. little is known of the mechanisms mediating the secretion of lysosomal enzymes. we have summarized evidence suggesting a role of microfilaments and microtubules in controlling enzyme release, but further studies of the bi ... | 1976 | 185100 |
| [mouse cytomegalovirus infection under cytosine arabinoside treatment]. | the antiviral activity of cytosine arabinoside (ara-c) against the mouse cytomegalovirus was investigated in animal experiments using various dosages. the substance did not exhibit any virostatic effect, but on the contrary fostered the viral infection. the virus concentration in the liver after administration of five dosages of 30 mg/kg of cytosine arabinoside was 35 times higher than that in untreated animals, and after five dosages of 45 mg/kg was 70 times higher. in addition the mortality ra ... | 1976 | 185154 |
| on the utilization of l-glutamine by glutamate dehydrogenase. | 1976 | 180990 | |
| isolation of mitochondria from ejaculated ram spermatozoa. | 1976 | 185406 | |
| anatomy of herpes simplex virus dna. vi. defective dna originates from the s component. | we previously reported that serial propagation of the justin strain of herpes simplex virus 1 [hsv-1 (justin)] results in the generation of defective dna molecules consisting of tandem repetitions of sequences of limited complexity. in the present study, hsv-1 dna was cleaved with the restriction endonucleases bglii and ecori. the fragments were electrophoretically separated on agarose gels, transferred to nitrocellulose strips, and then hybridized with 32p-labeled hsv-1 (justin) defective dna. ... | 1976 | 185428 |
| in vivo activation by polymyxin b of phospholipase from pseudomonas aeruginosa and escherichia coli. | 1976 | 181357 | |
| disruption of the fucose pathway as a consequence of genetic adaptation to propanediol as a carbon source in escherichia coli. | in escherichia coli, l-fucose is dissimilated via an inducible pathway mediated by l-fucose permease, l-fucose isomerase, l-fucose kinase, and l-fuculose 1-phosphate aldolase. the last enzyme cleaves the six-carbon substrate into dihydroxyacetone phosphate and l-lactaldehyde. aerobically, lactaldehyde is oxidized to l-lactate by a nicotinamide adenine dinucleotide (nad)-linked dehydrogenase. anaerobically, lactaldehyde is reduced by an nadh-coupled reductase to l-1,2-propanediol, which is lost ... | 1976 | 181364 |
| thyroid peroxidase, thyroglobulin, camp and dna in human thyroid. | tissues from normal thyroid, euthyroid multinodular goiter, toxic goiter, hashimoto's thyroiditis, thyroid adenoma, and carcinoma were examined for their content of deoxyribonucleic acid (dna), thyroid peroxidase activity (tpa), thyroglobulin (tg), and adenosine 3',5'-cyclic monophosphate (camp). compared with normal thyroids dna was increased in the neoplastic tissues and decreased in euthyroid multinodular goiter. quantitative changes of thyroglobulin were observed, especially in the thyroid t ... | 1976 | 181398 |
| growth on d-arabitol of a mutant strain of escherichia coli k12 using a novel dehydrogenase and enzymes related to l-1,2-propanediol and d-xylose metabolism. | escherichia coli k12 cannot grow on d-arabitol, l-arabitol, ribitol or xylitol (reiner, 1975). using a mutant of e. coli k12 (strain 3; sridhara et al., 1969) that can grow on l-1,2-propanediol, a second-stage mutant was isolated which can utilize d-arabitol as sole source of carbon and energy for growth. d-arabitol is probably transported into the bacteria by the same system as that used for the transport of l-1,2-propanediol. the second-stage mutant constitutively synthesizes a new dehydrogena ... | 1976 | 181526 |
| assessment of effect of starvation, glucose, fatty acids and hormones on alpha-decarboxylation of leucine in skeletal muscle of rat. | the present investigations of rates of oxidation of [u-14c] or [1-14c]leucine by homogenates of gastrocnemius muscle of fed and starved rats have indicated that 14co2 production is mainly the result of alpha-decarboxylation of leucine in this tissue. this incomplete oxidation was not the result of imparied tricarboxylic acid cycle since the oxidation of palmitate proceeded to completion within the experimental conditions. in the subsequent studies, the effect of altered nutrition and metabolic f ... | 1976 | 181544 |
| comparative membrane microviscosity of fish and mammalian rhabdoviruses studied by fluorescence depolarization. | the microviscosity of the hydrophobic region of the membrane of infectious hematopoietic necrosis virus was determined using fluorescence depolarization analysis of the probe 1,6-diphenyl-1,3,5-hexatriene and was found to be much lower at 37 c than that of another rhabdovirus, vesicular stomatitis virus. however, the microviscosity of this fish virus at 18 c, the temperature at which it was grown, corresponded to the microviscosity of vesicular stomatitis virus at 37 c. data obtained with the fi ... | 1976 | 181597 |
| unified mass-action theory for virus neutralization and radioimmunology. | all ideas implicit in the papers since 1953 involved in applying mass-action thermodynamics to antibody-antigen reactions are unified by the use of: (a) the intermediary concept of extent of reaction; (b) the concept of intrinsic association constant; (c) a statistical analysis for probable complexes; and (d) identification of the complex or complexes that contribute to the bioassay. several general theoretical examples are given that show the limitations of linear interpretations of equilibrium ... | 1976 | 185688 |
| [experimental aortic stenosis, its subsequent correction and the activity of oxidative enzymes in the myocardium]. | the activity of the respiratory enzymes of myocardial mitochondria--succinatedehydrogenase and cytochromixidase--was studied in experimentally induced aortic stenosis and after its elimination in 98 mongrel dogs. the observation period of stenosis was 1, 15, 30 and 60 days, and after its elimination--1, 7, 15 and 30 days. the activity of the enzymes in question was found to grow after the production of aortic stenosis. the highest level of their enzymatic activity was observed on the 15th day af ... | 1976 | 181629 |
| the fifth a.j. kluyver memorial lecture delivered before the netherlands society for microbiology on october 9th, 1975, at the delft university of technology, delft. the physiology of hydrogen bacteria. | 1976 | 185955 | |
| interaction of digitoxigenin with lecithin membranes. | the binding of digitoxigenin to lecithin model membranes was investigated by application of electron spin- and nuclear magnetic resonance methods. a digitoxigenin spin-label derivative was found to bind specifically to the pseudohexagonal rigid lattice of lecithin membranes. the binding is accomplished by some of the structural features which are required for the biological activity of cardiac glycosides. digitoxigenin has a procooperative effect on dipalmitoyl-lecithin membranes. the induction ... | 1976 | 181688 |
| a protein-binding assay for direct determination of adenosine 3',5'-monophosphate in amniotic fluid, cerebrospinal fluid, plasma, and urine. | an adenosine 3',5'-monophosphate (cyclic amp)-binding protein was isolated from bovine skeletal muscle. this preparation showed maximum binding capacity for cyclic amp at the physiological ph of amniotic fluid, cerebrospinal fluid, and plasma and had a high association constant of 1.4x10(9) 1/mol. this preparation of binding protein, together with albumin and edta in the assay buffer, gave a sensitive and specific competitive protein-binding assay that permitted direct determination of cyclic am ... | 1976 | 181838 |
| [application of scanning electron microscopy in the evaluation of iron content of human synovial membrane]. | 1976 | 181851 | |
| [aujezky's disease in the field and vaccination against the disease (author's transl)]. | a rather extensive outbreak of aujeszky's disease in the area served by the above veterinarians is reported. of 252 pig-breeding farms, eighty-two were contaminated. the other herds (170) were partly (81) vaccinated against the disease with the bartha strain. unlike de non-vaccinated group, the immunized herds showed few of any losses. in view of this fact it is concluded that aujeszky's disease vaccination is a useful procedure (even in a contaminated environment). | 1976 | 181864 |
| experimental study of dibutyryl cyclic amp: its antishock effects observed in traumatic shock rats. | antishock effect of n6, o2-dibutyryl cyclic amp (dbcamp) was investigated in rats subjected to noble-collip drum trauma and compared with effects of hydrocortisone and trasylol. results obtained are as follows. 1)hydrocortisone and trasylol administered 1 hr before initiating drumming improved the survival rate from traumatic shock with concomitant reducton of levels of acid phosphatase and beta-glucuronidase in circulating blood. dbcamp administered i.p. immediately after trauma also improved t ... | 1976 | 181867 |
| interaction of paraquat with the pulmonary microsomal fatty acid desaturase system. | 1976 | 181870 | |
| [spectrum analysis in the study of intracellular regulation of the metabolism of substances and engery]. | 1976 | 181881 | |
| [new structural components detected in b. pertussis of different serotypes]. | the authors present electron microscopic data on the study of morphological peculiarities of the strains belonging to various serological types. all the strains studied had a structure characteristic of gram-negative bacteria. two types intracellular membranes and intracytoplasmic crystal-like structures were revealed in a number of strains (no. 222, no. gz353, no. 475), irrespective of the serological types. dynamics of formation of the crystal-like structures in the bacterial cell was describe ... | 1976 | 181929 |
| aflatoxins. | 1976 | 186390 | |
| action of metabolic inhibitors on axenically grown entamoeba histolytica. | 1976 | 186406 | |
| [stick-plaque test--an economic method of quantitative determination of viruses]. | an economic method for quantitative assay of viruses is presented. in this "canule stick-plaque test" (german abbreviation spt) samples of viruses, geometrically diluted and taken up by a canule, are inoculated by sticking into monolayer cell cultures overlayed with agar medium. a plaquelike cpe detectable by neutral red staining develops in the area of the inoculation. the frequency of this cpe formation depends on the concentration of viruses in the inoculated dilution. this dose-response allo ... | 1976 | 186533 |
| the effect of cyclic amp on catabolite repression of isocitrate lyase in nocardia salmonicolor (ncib9701). | 1976 | 186557 | |
| meningitis due to combined infections. association of haemophilus influenzae type b and clostridium perfringens. | haemophilus influenzae type b and clostridium perfringens were recovered simultaneously from the cerebrospinal fluid of a patient with purulent meningitis. no antecedent history of head trauma was present to explain the coexistence of the anaerobe with haemophilus organisms. a review of the literature on mixed meningitis indicates that no previous cases of anaerobes have been reported in uncomplicated meningitis due to multiple organisms. in addition, the recovery of clostridia is extremely unus ... | 1976 | 181982 |
| arthrobacter luteus restriction endonuclease recognition sequence and its cleavage map of sv40 dna. | the nucleotide sequence at the cleavage site of the restriction endonuclease isolated from arthrobacter luteus (alu) has been determined. the endonuclease cleaves at the center of a palindromic tetranucleotide sequence to give even-ended duplex dna fragments phosphorylated at the 5'-end. the endonuclease cleaves sv40 form i dna into 32 fragments. the order and sizes of these fragments have been determined to provide an alu cleavage map of the sv40 genome. | 1976 | 182213 |
| [effect of aldosterone and acth administration on fluctuation of 5-ht content of the brain and pentobarbital anesthesia in adrenalectomized rats]. | the present study was undertaken to determine whether or not adrenalectomy influences anesthesia and increase in brain 5-ht induced by pentobarbital and if such is the case, whether or not aldosterone or acth inhibit the effect of adrenalectomy. male wistar rats were adrenalectomized or sham-operated and injected with aldosterone (20mug5hg i.p.), acth (5.0 mg/kg i.p.) or the vehicle (1.0 ml/kg i.p.) everyday for 1 week after a postoperative interval of 3 days. these rats ware given a normal diet ... | 1976 | 182623 |
| a sensitive and reproducible assay for the quantitation of erythrophagocytosis and its correlation with reduction in tritiated thymidine uptake in a tumor target cell system modified by immunoenhancing or immunosuppressive agents. | a new and sensitive assay procedure for studying erythrophagocytosis is described. the assay technique permits quantitation of the in vivo and in vitro effects of chemicals, hormones, and cell, or microbrial products, on the level of phagocytic activation of glass-adherent cells. the effect of intraperitoneal injection of bcg, zymosan, vitamin a, b. pertussis, cortisone, estrone, and thioglycollate on phagocytic activation of peritoneal exudate cells harvested from two days up to 28 days followi ... | 1976 | 182642 |
| rna synthesis in cells infected with herpes simple virus. xiii. differences in the methylation patterns of viral rna during the reproductive cycle. | herpex simplex virus 1 (hsv-1) rna labeled with with [methyl-3h] methionine at various times during the infectious cycle and purified by hybridization to viral dna was analyzed for the presence of methylated nucleotides. the data indicate the following. (i) rna labeled from 0 to 14 h postinfection and accumulating in the cytoplasm contained internal base-methylated nucleotides and terminal oligonucleotides consistent with the structure 7mg(5')ppp-(5')xmpympnp. similar methylated nucleotides and ... | 1976 | 186635 |
| comparative studies on mitochondrial coupling factor b and fb. | 1976 | 183765 | |
| morphological evidence for the translocation of lysosomal organelles from cytotoxic macrophages into the cytoplasm of tumor target cells. | in this study we have recorded in detail the morphological sequence of interactions between activated macrophages and tumor target cells in vitro. the study is unique because it involves the combination of several microscopic techniques that are used sequentially to study a single cell-to-cell interaction. many such cellular interactions were examined first by time lapse cinematography; then the effector cell was identified by specific immunofluorescence, and the areas of interaction were proces ... | 1976 | 187323 |
| lysine-sensitive aspartokinase of escherichia coli k12. synergy and autosynergy in an allosteric v system. | the interactions of the lysine-sensitive aspartokinase of e. coli k12 with lysine and leucine, as evidenced in the inhibition and binding curves, are well explained by the equations of an allosteric v model. mathematical treatments of such a model lead to new linearized plots. these representations are applied to our experimental results and allow the direct determination of some parameters of the model (equilibrium constant l' and leucine dissociation constants). the other parameters are obtain ... | 1976 | 183809 |
| medulloblastomas and other neural tumours in mice treated neonatally with n-ethyl-n-nitrosourea. | newborn mice of four inbred strains were injected with a single dose of n-ethyl-n-nitrosourea. the wide range of tumours induced included a small number in the central and peripheral nervous systems. the 4 brain tumours all arose in the cerebellum. three in one strain were medulloblastomas showing continuity with the internal granular layer. all three tumours showed diffuse infiltration through the molecular layer and continuity with densely-packed islets of cells that marginated immediately ben ... | 1976 | 184641 |
| key enzymes of imp metabolism: transformation and proliferation-linked alterations in gene expression. | 1976 | 184699 | |
| restriction enzymes do not play a significant role in haemophilus homospecific or heterospecific transformation. | competent haemophilus influenzae rd recipients, either as phage hp1 restricting (r+) or nonrestricting (r-) nonlysogens or defective lysogens, were exposed to deoxyribonucleic acids from various wild-type phage hp1 lysogenic h. influenzae serotype strains (non-encapsulated derivatives of serotypes a,b, c, d, and e), to dna from lysogenic haemophilus parahaemolyticus, and to dna from modified and nonmodified phage hp1. transformation of antibiotic resistance markers and of prophage markers in hom ... | 1976 | 185196 |
| enumeration of antigen reactive t cells against sheep erythrocytes by the virus plaque assay. | 1976 | 185443 | |
| [comparative characteristics of the lipoproteins of the human vascular wall and blood plasma]. | electrophoresis in the polyacrylamide gel and ultracentrifugation with a multistage density gradient demonstrated virtually the whole of the blood plasma lipoproteids spectrum to be contained in the human aortal wall. an immunological identity of the whole beta- and alpha-lipoproteids and also of their individual apoproteins in the aortal wall and blood plasma was ascertained. moreover, the ratio of etherified cholesterol/total cholesterol in the vascular and plasmatic lipoproteids proved to be ... | 1976 | 185447 |
| demonstration of the production of human thyroid-stimulating immunoglobulins (htsi) by graves' lymphocytes cultured in vitro with phytohaemagglutinin (pha). | the lymphocytes from patients with graves' disease or from healthy subjects have been cultured in vitro either alone or with phytohemagglutinin (pha). after six days the culture supernatants have been assayed for their human thyroid-stimulating activity by measuring increases in adenosine 3',5' monophosphate (cyclic amp) in human thyroid slices with which the supernatants have been incubated. significant levels of human thyroid stimulator activity were found in the culture in which graves' lymph ... | 1976 | 185485 |
| interrelationships between the central nervous system and patterns of adrenocorticotropic secretion following acute exposure to severe environmental conditions. | 1976 | 187557 | |
| susceptibility of chickens to avian encephalomyelitis virus. iv. behavior of the virus in laying hens. | some laying hens 6 months of age were inoculated subcutaneously or orally with a chick embryo--adapted strain of avian encephalomyelitis virus and examined for propagation of the virus in the body. when inoculated subcutaneously, the virus appeared in liver, spleen, ovarian follicle, and muscle at the site of inoculation 1 day, in kidney and lumbar part of the spinal cord 3 days, in the pancreas 5 days, in heart, duodenum, and cervical part of the spinal cord 7 days, and in the brain 11 days aft ... | 1976 | 185529 |
| physiology and pathophysiology of glucagon. | 1976 | 185634 | |
| immunologic identification of epstein-barr virus early antigen in a p3hr-1 cell extract. | we extracted the epstein-barr soluble antigen (ebsa) from the p3hr-1 human lymphoid cell line, which carries the epstein-barr virus (ebv), after p3hr-1 cells were activated with 5-iodo-2'-deoxyuridine. ebsa was identified as the early antigen (ea) complex by immunodiffusion and blocking immunofluorescence tests with high-titered human antiserum to ea. the identity of the ea complex was confirmed with antiserum to ea prepared in rabbits and adsorbed to assure its immunologic specificity. the ea w ... | 1976 | 187767 |
| systemic stress in the production of cardiac thrombosis in hypercholesterolaemic rats. | an experimental study to elucidate the effects of feeding a high fat diet, hypercholesterolaemia and superadded acute and chronic stress on the production of cardiac thrombosis was carried out in rats. the high fat diet contained 25 percent butter rat providing 45 percent calories from fat which produced significant increase of serum cholesterol and other lipids. acute stress was induced by two injections of adrenaline on a single day which caused a marked transient alteration of haemodynamics. ... | 1976 | 185673 |
| azathioprine: effects on neuromuscular transmission. | the neuromuscular effects of azathioprine were examined in the in-vivo cat soleus muscle preparation. in concentrations ranging from 10 to 1,000 mug/kg, administered intra-arterially, the agent caused motor axons to fire repetitively and produced a dose-related increase in the force of contraction. the drug reversed neuromuscular blockage produced by d-tubocurarine and potentiated the neuromuscular blockade produced by succinylcholine. the effects of theophylline, a phosphodiesterase inhibitor, ... | 1976 | 185925 |
| [respiratory pathology caused by mycoplasma pneumonia and its involvement in an adult pneumology hospital service]. | 1976 | 188160 | |
| [synthesis of virus-specific rna under conditions of homologous and heterologous interference by newcastle disease virus]. | homologous and heterologous interference by newcastle disease virus (ndv) was manifested in a marked inhibition of virus-specific rna synthesis of both the interacting viruses. inactivation of the interfering ndv by irradiation reduced its capacity to inhibit the synthesis of virus-specific rna of the homologous virus, leaving its effect on the synthesis of rna of the heterologous virus unchanged. in contrast, treatment of cell cultures with heparin leading to reduced interferon production elimi ... | 1976 | 188251 |
| glk: a locus controlling galactokinase activity in the mouse. | inbred strains of mice exhibited significant variation in whole blood galactokinase (galk) activity. activities tend to cluster into two classes, one class having approximately twice the activity of the other. hybrids (f1) between "high" and "low" strains have activity intermediate between the parental activities. two sets of recombinant inbred (ri) lines were developed by brother-sister mating, beginning with f2 generations of crosses between different pairs of high and low galk activity strain ... | 1976 | 186024 |
| ovarian adenosine 3':5'-cyclic monophosphate-dependent protein kinase(s). regulation by choriogonadotropin and lutropin in rat ovarian cells. | choriogonadotropin and lutropin have been found to activate cyclic amp-dependent protein kinase in ovarian cells isolated by collagenase dispersion from immature rats. the stimulatory effect of gonadotropins was dependent on both hormone concentration and incubation time. choriogonadotropin at 1 mug/ml fully stimulated the protein kinase activity within 5 min of incubation, and this effect was specific for choriogonadotropin and lutropin-like activity. in addition, protein kinase activity has be ... | 1976 | 186032 |
| activities and some properties of adenylate cyclase and phosphodiesterase in muscle, liver and nervous tissues from vertebrates and invertebrates in relation to the control of the concentration of adenosine 3':5'-cyclic monophosphate. | 1. the basal and fluoride-stimulated activities of adenylate cyclase, and the maximal activities of 3':5'-cyclic amp phosphodiesterase and 3':5'-cyclic gmp phosphodiesterase, together with the km values for their respective substrates, were measured in muscle, liver and nervous tissues from a large range of animals to provide information on the mechanism of control of cyclic amp concentrations in these tissues. high activities of adenylate cyclase and cyclic amp diesterase are found in nervous t ... | 1976 | 186042 |
| isoprenaline stimulation of cyclic amp production by isolated cells from adult rat myocardium. | 1976 | 186060 | |
| occurrence of bovine papular stomatitis. | 1976 | 189223 | |
| naturally-occurring neonatal canine herpesvirus infection. | the detailed clinical and epidemiological history and the pathology of neonatal canine herpesvirus (chv) disease in a naturally infected litter of pups is reported. herpesvirus was isolated from the brain, lung, liver, spleen, kidney and intestine of one of the affected litter which died on day 10 after whelping. the isolation of virus correlated with the distinctive gross and histological changes in these organs. herpesvirus was isolated also from the anterior vagina of the bitch 18 days after ... | 1976 | 189479 |
| detection of adenovirus antigens in sendai virus-induced multinucleate cells by fluorescent antibody technic. | 1976 | 190337 | |
| enhancement of polysome formation and protein synthesis in sendai virus-infected cells. | a considerable stimulation of total protein synthesis in sendai virus-infected chicken fibroblasts occurred 18 h after infection. the stimulation of synthesis was shown to be due mainly to the synthesis of virus-specific proteins; the synthesis of host proteins was either unchanged or slightly enhanced. the level of functional polyribosomes in virus-infected cells was also increased as compared to that in mock-infected control while the number of free 80s ribosomes was proportionally decreased. | 1976 | 180240 |
| characterization of two particle types of calf rotavirus. | two distinct types of rotavirus particle were isolated in caesium chloride density gradients. the higher density particle banded at 1-38 g/ml and measured 55 +/- 0-4 nm in diameter while the less dense particle banded at 1-36 g/ml, measured 66 +/- 0-4 nm in diameter and appeared to possess an extra outer capsid layer. some forms intermediate between the two types were seen. since the two particles had a similar but not identical morphology and polypeptide composition, they were considered to be ... | 1976 | 180243 |
| decrease of homovanillic, dihydroxyphenylacetic acid and cyclic-adenosine-3',5'-monophosphate content in the rat caudate nucleus induced by the acute administration of an aminoacid mixture lacking tyrosine and phenylalanine. | 1976 | 180254 | |
| antibodies to epstein-barr virus in neurological diseases. | an association of evidence of epstein-barr virus (ebv) infection in 3 different cases of neurological disease not related to infectious monomucleosis is reported. a rise in antibody titres to ebv-viral capsid antigen (vca) and early antigen (ea) in the serum and csf was demonstrated in a patient with acute encephalitis and in a patient with a psychotic-like organic brain syndrome. both patients demonstrated albuminocytological dissociation in the cerebrospinal fluid. igm antibodies specific to e ... | 1976 | 180262 |
| proposed structure for brain adenylate cyclase purified using blue dextran-sepharose chromatography. | 1976 | 180424 | |
| relationship between receptor and mammary tumour virus production after stimulation by glucocorticoid. | a short exposure of primary cultures of mouse mammary tumour cells to glucocorticoids results in at least a three-fold stimulation of mammary tumour virus (mtv) production. specific interaction of glucocorticoids with the cytoplasmic and nuclear receptors can also be demonstrated. the biological potency of various steroids to stimulate mtv is related directly to the retention of the steroid-receptor complex in the nuclei. progesterone has a high affinity for the cytoplasmic receptor, is not reta ... | 1976 | 180430 |
| influence of bcg vaccination on the primary and transplantable hamster tumors induced by sv40 and on the specific sv40 virus-induced antitumor immunity. | the main purpose of the study was the estimation of the effect of bcg vaccination and bcg in the combination with the specific immunization with sv40 on the incidence of primary and growth of transplantable sv40-induced tumors in syrian hamsters. different bcg vaccine preparations containing 60--100 millions of viable mycobacteries per 1 mg were used. it has been demonstrated that one and two intradermal injections of bcg (0.25 mg per animal) during the latent period in syrian hamsters inoculate ... | 1976 | 180441 |
| congenital cytomegalovirus infection. | 1976 | 180500 | |
| phosphatidylglycerol biosynthesis in bacillus licheniformis resolution of membrane-bound enzymes by affinity chromatography on cytidinediphospho-sn-1,2-diacylglycerol sepharose. | cytidinediphospho-sn-1,2-diaclglycerol (cdp-diglyceride) has been covalently linked to sephrose 4b via adipic acid dihydrazide spacer arm forming an effective affinity chromatography column. this liponucleo-tide ligand and sn-glycero-3-phosphate are subtracts for the formation of 3-sn-phoshatidyl-1'-sn-glycero-3'-phosphate (pgp) catalyzed in both eukaryotic and prokaryotic organisms by sn-glycero-3-phosphate: cmp phosphatidlytranferase (pgp synthetase). using this cdp-diglyceride sephrose aff ... | 1976 | 175832 |
| direct radioimmunoassay for serum estriol during pregnancy. | i describe an assay for serum estriol during pregnancy, which does not require prior extraction or chromatography of the serum. fifty microliters of 20-fold diluted serum can be assayed to detect as little as 20 pg of estriol. for a 20 mug/liter serum estriol concentration the cv was 16%; for 100 mug/liter concentration it was 5%. there was no significant interference by serum "binding" proteins. the assay measures unconjugated estriol, estriol conjugated with either sulfate or glucuronide at th ... | 1976 | 175980 |
| changes in the immunoelectrophoretic characteristics of serum alpha-i-lipoprotein induced by various dyes. | the effect of 8 dyes on the electrophoretic mobility of normal human serum alpha-1 lipoprotein has been examined. the two characteristics of increase in anodal mobility, and conformational changes of the immunoelectrophoretic precipitin arc suggesting polymorphism, were found to vary independently among the dyes tested. the results suggest that dye induced electrophoretic mobility alteration may represent a useful tool for examination of heterogeneity of alpha-1 lipoprotein. | 1976 | 175982 |
| adenyl cyclase system and cerebral energy state. | the energy charge potential of the cerebral adenylate system, the cerebral lactate: pyruvate system, and the cerebral glycogen level were used to characterize the cerebral energy state of the brain. cerebral adenyl cyclase activity and cyclic amp concentrations were investigated to evaluate their possible influence on the regulatory processes in brain metabolism. these biochemical parameters were evaluated on the cortical motor area of the brain of the beagle dog in hypovolaemic hypotension duri ... | 1976 | 176328 |
| genetic analysis of mammary tumor induction and expression of mammary tumor virus antigen in hormone-treated ovariectomized gr mice. | early stages of mammary tumors (emt) were induced with a combined treatment of progesterone (p) and estrone (e) in ovariectomized adult grs/a (gr) mice, a strain of european origin and with a high incidence of mammary cancer. the mammary tumors were comparable to the pregnancy-dependent tumors of breeding females of this strain. the hormone treatment did not lead to emt in a variety of other strains and only occasionally in the riii an c3h strains. treatment with p or e alone di not lead to emt ... | 1976 | 176379 |
| chemical modification of simian virus 40 dna by reaction with a water-soluble carbodiimide. | superhelical simian virus 40 (sv40) dna i can be modified with n-cyclohexyl-n'-beta-(4 methylmorpholinium)ethylcarbodiimide (cmc). the reaction produces an increase in the sedimentation velocity of dna i from 21 to 22.5s and a decrease in its buoyant density in cscl from 1.694 to 1.688. a comparable shift in buoyant density is observed in a saturated ethidium bromide-cesium chloride gradient where form ii, which has been exposed to cmc, shows no shift. the cscl-buoyant density data allows us to ... | 1976 | 176461 |
| iodination of dna. studies of the reaction and iodination of papovavirus dna. | iodination of dna by the reaction originally described by s. l. commerford ((1971), biochemistry 10, 1993) is extremely sensitive to the secondary structure of the dna. cytidines in denatured simian virus 40 (sv40) dna react at a slightly slower rate than free cytidine monophosphate; hydrogen-bonded cytidines in sv40 form i dna are iodinated considerably more slowly; elimination of the negative supercoils in form i dna by conversion to form ii or form iii reduces reactivity even further. the res ... | 1976 | 175828 |
| radioimmunoassay of 17beta-hydroxy-5alpha-androstan-3-one, 4-androstene-3,17-dione, dehydroepiandrosterone, 17-hydroxyprogesterone and progesterone and its application to the human male plasma. | 1976 | 178963 | |
| neural properties of cultured human endocrine tumor cells of proposed neural crest origin. | cells from human endocrine tumors of proposed neural crest origin--five pheochromocytomas, two medullary carcinomas of the thyroid, and two bronchial carcinoids--were grown in monolayer culture. cells from all nine tumors, including epithelial forms of medullary carcinoma of the thyroid and bronchial carcinoid cells, and epithelial and neuron-like pheochromocytoma cells demonstrated all-or-nothing, short-duration action potentials. | 1976 | 179139 |
| critical density for relaying in dictyostelium discoideum and its relation to phosphodiesterase secretion into the extracellular medium. | the critical cell density for relaying in d. discoideum, n*, has been measured as a function of cell density, n, and time after harvesting, t. it has logarithmic dependence on n for 2.5 x 10(4)/cm2 less than n less than 7.5 x 10(5)/cm2 and saturates for n more than 1.0 x 10(6)/cm2. n* is an increasing function of time after harvesting. the phosphodiesterase (pde) secretion rate on which n* depends is a constant. expressions were derived which relate n* to pde secretion and diffusion. they have b ... | 1976 | 175073 |
| chemotherapeutic effects of some alkylating derivatives of nitrosourea on the development of tumors transplacentally induced in rats by enu. | the application of bcnu, ccnu and meccnu has been shown to greatly reduce the number of tumors induced in rats by transplacentally administered enu and to inhibit the full development of tumor proliferation. moreover, no neurinomas appeared after treatment with ccnu. the application of gcnu proved to be much less effective. our statistics in the form of tables showing these findings are included and discussed. | 1976 | 175631 |
| [the differentiation of h. influenzae and. h. parainfluenzae (author's transl)]. | 1976 | 179719 | |
| [dynamics of sleep and the waking state after labyrinthine deafferentation]. | the author carried out studies on awake state and sleep (slow and paradoxal) after lybyrinth deafferentation. the states were evaluated by behavior, eeg, myogram and eye movements. the labyrinth defferentation was performed in combination (chemical and mechanical). bilateral labyrinth deafferentation reduced the duration of the awake state from 30% to 17%, p less than 0.001. the slow sleep was increased at the same time but there was no statistical significance. the parodoxal sleep was due both ... | 1976 | 179775 |
| immunopathogenicity and oncogenicity of murine leukemia viruses. ii. infection of mice and rats with scripps leukemia virus. | the pathologic consequences of infection of newborn mice and rats with mulv (scripps leukemia virus--slv) were observed. serum mulv p30 concentrations of most strains were elevated 20 to 100 times that of controls while mulv gp70 levels were elevated only 1.1 to 14.8 times, probably reflecting in part the higher concentrations of gp70 in control sera but also indicating the lack of parallelism in regulation of synthesis of these two viral antigens. infected mice of most strains developed immunol ... | 1976 | 175661 |
| brown adipose tissue mitochondria: recoupling caused by substrate level phosphorylation and extramitochondrial adenosine phosphates. | 1. uncoupled oxidative phosphorylation in isolated guinea pig brown-adipose-tissue mitochondria is reflected by a low phosphorylation state of adenosine phosphates in the mitochondrial matrix and in the extramitochondrial space during oxidation of succinate or glycerol 1-phosphate in the presence of serum albumin and 100 mum adp. recoupling of respiration and phosphorylation in the mitochondria is indicatdd by a dramatic increase in the phosphorylation state of adenine nucleotides in both compar ... | 1976 | 174912 |
| croton oil- and benzo(a)pyrene-induced changes in cyclic adenosine 3':5'-monophosphate and cyclic guanosine 3':5'-monophosphate phosphodiesterase activities in mouse epidermis. | the topical application of croton oil, benzo(a)pyrene, acetic acid, and 12-o-tetradecanoyl-phorbol-13-acetate to mouse skin caused an increase in the activity of epidermal low-affinity cyclic adenosine 3':5'-monophosphate (cyclic amp) phosphodiesterase. the increase was most pronounced with croton oil, began between 4 and 6 hr after application of this material, and was maintained for at least 48 hr. the activity of cyclic guanosine 3':5'-monophosphate phosphodiesterase was also increased by tre ... | 1976 | 174815 |
| comparison of guinea pig cytomegalovirus and guinea pig herpes-like virus: pathogenesis and persistence in experimentally infected animals. | the pathogenesis of guinea pig cytomegalovirus (gpcmv) and guinea pig herpes-like virus (gphlv) in guinea pigs was compared. animals were inoculated with the two viruses by different routes and sacrificed after varying periods of time. gpcmv was consistently isolated from salivary gland 2 weeks postinoculation and thereafter following intraperitoneal or subcutaneous incoulaton. virus was less frequently found in other tissues including blood, spleen, and kidney. intranuclear inclusions were seen ... | 1976 | 178599 |
| investigations on isolated islets of langerhans in vitro. xiii. experiments concerning the preparation conditions with collagenase. | during the digestion of pancreatic pieces with collagenase for prepartion of isolated islets the enzymes in incubation medium (collangenolytic and/or proteolytic) can alter the secretion behavior of a- and b-cells. insulin release after such an enzymatic attack is characterized by an enhanced basal secretion and a diminished and delayed glucose response. overdigestion results in a decreased glucagon secretion in response to arginine, a diminished insulin content, and a decreased thiol-protein-di ... | 1976 | 178501 |
| studies on the stimulation of camp metabolism in human lymphocytes by latex polymers. | 1976 | 178514 | |
| distribution of phosphatidylinositol biosynthetic activities among cell fractions from rat liver. | 1976 | 178302 | |
| synchronous digestion of sv40 dna by exonuclease iii. | we have established an optimal condition for the synchronous digestion of sv40 dna with escherichia coli exonuclease iii. electron microscopy and polyacrylamide gel electrophoresis were used to obtain accurate measurements on the lengths of dna before and after exonuclease iii digestion. based on this finding, a new method for determining the sequence of long duplex dna can be realized. it involves (a) the synchronous digestion of the dna from the 3' ends with exonuclease iii, followed by (b) re ... | 1976 | 174717 |
| [case of rhinopneumonia in horses in kirghizia]. | 1976 | 178089 | |
| the unique identity of rat hepatoma phenylalanine hydroxylase. | 1976 | 174569 | |
| effect of hormones on cyclic amp levels in cultured human cells. | 1976 | 177016 | |
| effect of infection with enveloped viruses on nucleotide metabolism. | 1976 | 176807 | |
| proposed structure of two defective viral dna oligomers produced in 3t3 cells transformed by the ts-a mutant of polyoma virus. | the various oligomeric viral dna species produced at 32 c by two related syblines of ts-a-transformed mouse 3t3 cells were characterized. results from the analysis of the cleavage products observed after digestion with restriction endonucleases from haemophilus parainfluenzae, escherichia coli ri, and haemophilus suis are consistent with the assumption that in both sublines, the major oligomeric component is a dimer from which a segment of different length is deleted. the major oligomeric (27s) ... | 1976 | 176437 |
| airborne transmission of polyoma virus. | polyoma virus (pv) infection was transmitted through the air of an animal laboratory. mice free of detectable antibodies to pv were exposed for 1 month to the airborne environment of laboratories housing naturally infected mice. the seroconversion rate was 75% (24/32), as measured by hemagglutination inhibition. control mice, housed in the sterile atmosphere of a mass air flow cabinet (mafc) in the same laboratory, had a seroconversion rate of 15.8% (3/19). airborne transmission occurred bia pv ... | 1976 | 176376 |
| comparative studies on plasma low density lipoproteins from pig and man. | 1976 | 175991 | |
| the influence of anerobiosis and nitrogen dioxide on the human erythrocyte. | 1976 | 176025 | |
| cyclic amp and cyclic gmp in rats paw edema by prostaglandins. | 1976 | 176058 | |
| editorial: herpesvirus and cancer of uterine cervix. | frequent coitus with several partners or at a very young age carries the greatest risk of cancer of the uterine cervix. lowest risk is among celibate women and those who live in communities where marriage is stable and where premarital and extramarital coitus is infrequent. all evidence points to the venereal hypothesis of cervical cancer. herpes simplex virus type 2 (hsv-2) has been implicated. immunological defenses, oxygen tension, ph, and hormonal changes in the cervical tissues may also ... | 1976 | 175880 |
| [pathogenic and therapeutic concepts in viral hepatitis]. | 1976 | 175890 |