Publications

[capacities of diagnostic volumetric multislice spiral computed tomography in the diagnosis of gastric cancer].	in the period 2009 to 2010, diagnostic multislice spiral computed tomography (msct) was carried out in 49 patients with gastric cancer. the efficiency of dynamic msct in detecting a tumor and determining its locoregional extent was evaluated. the results of dynamic msct were compared with those of postoperative histological examination. the possibility of detecting gastric cancer by dynamic msct was ascertained to depend on the depth of tumor invasion and to average 29, 71, 72, and 77% for t1, t ...	2011	22288146
severe rhabdomyolysis and acute renal failure in an adolescent with hypothyroidism.	hypothyroidism has been reported rarely as the cause of rhabdomyolysis in adults and children. we present here a non-compliant adolescent with a diagnosis of hypothyroidism who developed rhabdomyolysis and acute renal failure with no additional predisposing factor. a 13-year-old girl with a previous history of hypothyroidism due to thyroid hypoplasia presented with generalized myalgia, malaise, vomiting, and oliguria lasting for three days. neurological examination revealed bilateral marked weak ...	2011	22272466
double-probe signal enhancing strategy for toxin aptasensing based on rolling circle amplification.	on the basis of aptamer-based rolling circle amplification (rca) and magnetic beads (mbs), a highly sensitive electrochemical method was developed for the determination of ochratoxin a (ota). initially, an amino-modified capture dna was immobilized onto mbs for the following hybridization with an ota aptamer and a phosphate labeled padlock dna. in the presence of ota, the aptamer would dissociate from the bioconjugate, and the padlock dna would subsequently hybridize with the capture dna to form ...	2011	22270050
segmental lesions in pityriasis rosea: a rare presentation.	a 34-year-old nonpregnant woman noted a mildly pruritic skin lesion on her right breast for 1 week following an episode of coryza, malaise, and low-grade fever of 3 days' duration. the latter symptoms subsided without any treatment. ketoconazole cream prescribed by her family physician did not resolve the breast eruption after 1 week, so was stopped. a week later, multiple skin lesions erupted suddenly on her right chest wall starting near the herald patch in midaxillary line and spread distally ...	2011	22256628
effects of fermented mushroom (flammulina velutipes) by-product diets on growth performance and carcass traits in growing-fattening berkshire pigs.	this study was conducted to investigate effects of fermented mushroom (flammulina velutipes) by-product diets on the growth performance and carcass traits in growing-fattening berkshire pigs. the fermented diets mainly contained 40.0% mushroom by-product, 20.0% formula feed, 26.0% rice bran and supplemental 0.1% probiotics. the mixed ingredients were fermented for 5days at room temperature. berkshire pigs (n=225) were divided into five groups and three replications. the basal diets (c) were subs ...	2011	22250740
[spectroscopic characteristics of dissolved organic matter in water from typical area of taihu lake].	fluorescence spectroscopy, uv spectroscopy, and multiple uv parameters were applied to determine and analyze the dissolved organic matter (dom) in water of taihu lake, in order to find out the sources and influencing factors of dom in water from typical areas of taihu lake. the results showed that the components of dom in water from different lake areas displayed some regional characteristics. the contents of macro-molecules matters with complex structures and humic substances in water from samp ...	2011	22242509
[clinical analysis of cervical lymph node metastasis of hypopharyngeal carcinoma].	to investigate the pattern of cervical lymph node metastasis in hypopharyngeal carcinoma.	2011	22242474
long-term survival after lung-sparing total pleurectomy for locally advanced (international mesothelioma interest group stage t3-t4) non-sarcomatoid malignant pleural mesothelioma.	there is a body of opinion that advocates extrapleural pneumonectomy (epp) as the only radical treatment option for locally advanced (t3/t4) malignant pleural mesothelioma (mpm). we tested the hypothesis that lung-sparing total pleurectomy (lstp) can be as effective as epp in locally advanced mpm with reduced risk.	2011	22219469
significance of a new fluorodeoxyglucose-positive lesion on restaging positron emission tomography/computed tomography after induction therapy for non-small-cell lung cancer.	restaging of patients with locally advanced non-small-cell lung cancer (nsclc) is of paramount importance, since only patients with down-staging after induction therapy will benefit from surgery. in this study, we assessed the aetiology of new (18)fluoro-2-deoxy-d-glucose (fdg)-positive focal abnormalities on restaging positron emission tomography/computed tomography (pet/ct) in patients with a good response after induction chemotherapy in the primary tumour and lymph nodes.	2011	22219415
the role of adjuvant in mediating antigen structure and stability.	the purpose of this study was to probe the fate of a model antigen, a cysteine-free mutant of bacteriophage t4 lysozyme, to the level of fine structural detail, as a consequence of its interaction with an aluminum (al)-containing adjuvant. fluorescence spectroscopy and differential scanning calorimetry were used to compare the thermal stability of the protein in solution versus adsorbed onto an al-containing adjuvant. differences in accessible hydrophobic surface areas were investigated using an ...	2011	22213631
effect of excess levels of lysine and leucine in wheat-based, amino acid-fortified diets on the mrna expression of two selected cationic amino acid transporters in pigs.	an experiment was conducted to evaluate the effect of excess levels of leu and lys on the expression of b(0,+) and cat-1 mrna in jejunum, liver and the muscles longissimus dorsi (ldm) and semitendinosus (stm). twenty pigs with an average initial bw of 16.4 ± 1.7 kg were used in a randomized complete block. dietary treatments (t) were as follows: t1, basal diet; t2, basal plus 3.5 g l-lys/kg diet; t3, basal plus 1.5 g l-leu/kg diet; t4, basal plus 3.5 g l-lys plus 1.5 g l-leu/kg diet. diets in t1 ...	2011	22211733
the correlation between type of anesthesia and the hormones levels during and after transvesical prostatectomy.	surgical intervention and anesthesia procedure lead to a series of hormonal changes in the organism, which is mainly attributed to catecholamine response to stress. surgical intervention is resulting in significant changes in neuroendocrine regulation, metabolism and physiological functions, as part of the overall response to stress. research aim: the aim of this study was to determine and evaluate the levels of hormones in patients undergoing transvesical prostatectomy under general or local an ...	2011	23408784
management of the stiff shoulder. a prospective multicenter comparative study of the six main techniques in use: 235 cases.	stiffness in the shoulder is a frequent symptom associated with a number of clinical entities whose management remains inadequately defined.	2011	22036993
comparison of short-term outcomes and perioperative systemic immunity of laparoscopy-assisted and open radical gastrectomy for gastric cancer.	to compare the perioperative systemic immunity of laparoscopy-assisted and open radical gastrectomy for gastric cancer.	2011	23672753
potentially pathogenic free-living amoebae (fla) isolated in spanish wastewater treatment plants.	this work studies the characterization of pathogenic free-living amoebae (fla) from sewage effluents. some of them, such as acanthamoeba, naegleria, hartmannella, sappinia, balamuthia and paravahlkampfia have been reported as a cause of diseases in humans. therefore, the study of their habitats and their pathogenicity has become necessary. the population of potentially pathogenic fla was analysed in five spanish wastewater treatment plants. five of the seven fla isolated were identified as genus ...	2011	23761343
congenital hypothyroidism with severe hypoganglionosis of the colon in a 10 years old girl, a case report.	we present a case report of congenital hypothyroidism in a ten year old ethiopian child, who presented after chronic constipation and abdominal distension since early infancy. she had been diagnosed to have sever hypoganglionosis of the colon at age of eight years, based on histopathological examination. she has short stature, and associated history of delayed dental eruption and shedding. barium enema study and radiography of extremity showed evidences of hypothyroidism. laboratory evaluation a ...	2011	23409402
[ear carcinomas in department of otolaryngology of the medical university of warsaw in years 2004-2008].	ear carcinoma constitutes 0.5% of all cancers of the head and neck hardly, however with poor prognosis. in the study we use university of pittsburgh staging system. this study is retrospective analysis of the surgical treatment outcomes of the patients with external and middle ear carcinomas in the ent department at the medical university of warsaw in years from 2004 to 2008. histopatologicallly, there were:18 squamous cell carcinoma, 17 basal cell carcinoma, 2 neuroendocrine carcinoma, basal ce ...	2011	22000249
efficacy of soy protein isolate as a fat replacer on physico-chemical and sensory characteristics of low-fat paneer.	the nutritional and textural properties of low fat paneer using soy protein isolate (spi) as fat replacer was investigated. the physico-chemical and sensory characteristics of 4 types of paneer made of low-fat milk (3% milk fat (mf) and 10% solids-not-fat (snf)) and spi of 0 (t1), 0.1 (t2), 0.2 (t3) and 0.3% spi (t4) were compared with high fat paneer (tc) made of high fat milk (6% mf and 9% snf). cacl2 (0.2%, w/v) was used as coagulant at 75 ± 1°c. increased level of spi in paneer increased yie ...	2011	23572778
the first phage electron micrographs.	the first phage electron micrographs were published in 1940 in germany and proved the particulate nature of bacteriophages. phages and infected bacteria were first examined raw and unstained. us american scientists introduced shadowing and freeze-drying. phages appeared to be tailed and morphologically heterogeneous. phage types identified by early electron microscopy include enterobacteriophages t4, t1, t7, t5, 7-11, vii and pseudomonas phage pb1. this paper retraces the development of early vi ...	2011	23050215
cmos conductometric system for growth monitoring and sensing of bacteria.	we present the design and implementation of a prototype complementary metal-oxide semiconductor (cmos) conductometric integrated circuit (ic) for colony growth monitoring and specific sensing of escherichia coli (e. coli) bacteria. the detection of e. coli is done by employing t4 bacteriophages as receptor organisms. the conductometric system operates by measuring the resistance of the test sample between the electrodes of a two-electrode electrochemical system (reference electrode and working e ...	2011	23851473
a molecular dynamics study of the interprotein interactions in collagen fibrils.	molecular dynamics simulations of collagen are used to investigate at the atomistic level the nature of the interprotein interactions that are present within a collagen fibril, and which are responsible for the fibril's thermodynamic stability. simulations both of a collagen fibril and of a fully solvated tropcollagen are compared in order to study the interactions that arise between the proteins upon the process of fibrillogenesis. the interactions studied include direct interprotein hydrogen b ...	2011	23526918
chronic peripheral administration of serotonin inhibits thyroid function in the rat.	we studied the effect of chronic intraperitoneal (ip) administration of serotonin (5-ht) and thyroid function. we injected daily intraperitoneally for 10 days different doses of 5-ht, and measured plasma thyroid hormones and tsh levels. there was a decrease in the plasma levels of t3 and t4 with medium doses of 5-ht (0.2 and 0.4 mg/kg bw for t3, and 0.2 for t4). no effects were evidenced on the plasma levels of tsh. in normal environmental conditions, the site action of 5-ht outside the blood-br ...	2011	23738246
diagnostic accuracy of fine needle aspiration cytology in thyroid swellings.	proper management of the disease depends upon accurate diagnosis. fine needle aspiration cytology has become the investigation of choice because of its high accuracy, simplicity, minimal-invasiveness, quick result and reliability.	2011	22929705
a phase ii study of docetaxel, cisplatin and 5- fluorouracil (tpf) in patients with locally advanced head and neck carcinomas.	the combination of cisplatin and 5-fluorouracil (pf) is currently considered a standard and effective regimen for the treatment of advanced head and neck carcinomas. the aim of this study was to evaluate the efficacy and safety of docetaxel, cisplatin and 5-fluorouracil (tpf) in patients with unresectable head and neck carcinomas.	2011	22737461
[the place of hartmann's resections for some advanced distal rectal cancers].	adrc involves the adjacent structures and systems in the minor pelvis and the achievement of the importent for the prognosis ro resection is technically challenging. the main problem is to obtain the circumferential clearance and it could require a hysterectomy, vaginal, ureteral, bladder resection or exsenteration. the restoration of the urinary tract integrity is obligatory, but the complications are common if the gut passage is restored too. an additional indication for a two-stage operation ...	2011	23844461
retrospective analysis of survival of patients with squamous cell carcinoma of the maxilla after primary resection and elective bilateral neck dissection: an institutional experience.	a retrospective analysis of the 5-year survival rates of patients who underwent treatment for oral squamous cell carcinoma (oscc) of the maxillary region was performed to analyse the prognostic factors for patient's survival.	2011	23483114
a case of resistance to thyroid hormone with chronic thyroiditis: discovery of a novel mutation (i54v).	resistance to thyroid hormone (rth) is a rare disorder characterized by variable tissue hyporesponsiveness to thyroid hormone, usually caused by mutations in the thyroid hormone receptor beta (trβ). it has been reported that the serum of patients with rth is free of auto-antibodies against thyroglobulin (tg) and thyroid peroxidase (tpo), except in rare cases where coincidental autoimmune thyroiditis is also present. we describe a 13-year-old girl with chronic thyroiditis and rth. this patient ha ...	2011	22937287
[the state of thyroid system in patients with non-traumatic supratentorial hematomas].	concentrations of thyroid hormones (thyrotrophic - ttg, t3, t4) were measured with radioimmunological assay in the blood serum of 69 operated patients with supratentorial stroke interbrain hematomas. hematomas were removed using a puncture/ aspiration method with local fibrinolysis. the lethality was 19%. it has been shown that medial hematomas lead to the decrease in ttg secretion while lateral and lobar ones inhibit t4 and t3 synthesis. replacement therapy with thyroid hormones is needed to im ...	2011	22792746
spontaneous spinal epidural haematoma due to arteriovenous malformation in a child.	spontaneous spinal epidural haematoma (sseh) is a rare clinical entity, especially in infants, in whom only a few cases have been reported. in a paediatric emergency setting, sseh should be considered as part of the differential diagnosis for acute extremity weakness and paraesthesia. epidural vascular malformations are often suspected in these cases but have rarely been demonstrated. the authors report herein a case of sseh in a 9-year-old boy arising from an epidural vascular malformation. he ...	2011	22696725
paraneoplastic subacute sensory neuronopathy in association with adenocarcinoma of the prostate.	paraneoplastic syndromes arise infrequently in prostate cancer and paraneoplastic subacute sensory neuronopathy has not previously been reported in association with prostate cancer. when paraneoplastic syndromes occur, it is usually in the setting of small-cell carcinoma of the prostate or advanced, hormone-resistant disease. here the authors report a 64- year-old man who developed a progressive, severe, sensory neuronopathy in the setting of a recently diagnosed stage t4 hormone-responsive pros ...	2011	22689835
"transferred to another institution": clinical histories of psychiatric patients murdered in the nazi "euthanasia" killing program.	this study aims to examine the practice of medical reporting in a totalitarian environment including systematic killing of people with mental illness in nazi germany. the historical analysis is based on patient documents and administrative files at today's district hospital, gunzburg, as well as on patient documents of inventory r 179 of the branch office of the federal archives (bundesarchiv) in berlin/lichterfelde. the paper describes four patient histories and attempts to reconstruct some asp ...	2011	22572090
primary sjögren's syndrome or multiple sclerosis? our experience concerning the dilemma of clinically isolated syndrome.	the authors present the case of a 50 years old woman who during 3 years had a transient right limbs palsy, and numerous episodes of unilateral/bilateral optic neuropathy. the csf and mri examinations did not sustain the diagnosis of multiple sclerosis (ms). after 2 years from the onset, she presented bilateral trigeminal neuropathy, and after 9 months the anti-ss-a and anti ss-b antibodies were positive. the sialography and the minor salivary ducts biopsy (in the absence of xerostomia and xeroph ...	2011	22568276
immediate intraocular pressure rise after intravitreal injection of ranibizumab and two doses of triamcinolone acetonide.	to evaluate prospectively immediate intraocular pressure (iop) changes after the intravitreal injection of ranibizumab, 2 and 4mg triamcinolone acetonide.	2011	22553690
successful treatment of t4 renal cell carcinoma after a neoadjuvant targeted therapy using sunitinib: report of a case.	since the introduction of targeted therapy, treatment of metastatic renal cell carcinoma (rcc) has undergone dramatic changes. responses to targeted therapy within the primary tumor and metastatic lesions are novel findings not seen with immunotherapeutic-based strategies. we report here a case of t4 rcc in which cytoreductive nephrectomy became possible after a neoadjuvant targeted therapy using sunitinib. our experience with the present case suggests that targeted therapy in the neoadjuvant se ...	2011	22531125
aggressive hemangioma of the thoracic spine.	vertebral hemangiomas are common lesions and usually considered benign. a rare subset of them, however, are characterized by extra-osseous extension, bone expansion, disturbance of blood flow, and occasionally compression fractures and thereby referred to as aggressive hemangiomas. we present a case of a 67-year-old woman with progressive paraplegia and an infiltrative mass of t4 vertebra causing mass effect on the spinal cord. multiple conventional imaging modalities were utilized to suggest th ...	2011	22470764
combined transoral and suprahyoid approach for oropharyngeal cancers: an alternative to mandibulotomy.	surgical treatment of oropharyngeal tumours usually requires mandibular osteotomy. using this technique allows a better exposure and an easier excision, but this approach often generates complications. since 1995, we used a less aggressive surgical technique, with a suprahyoid pharyngotomy when the oral approach was not sufficient, thus sparing the mandible.	2011	22416489
protection of penaeus monodon from infection of white spot syndrome virus by dna construct expressing long hairpin-rna against icp11 gene.	a plasmid construct (picp11-lh) was designed to constitutively express long-hairpin rna (lhrna) against icp11 gene, which is reportedly the most highly expressed gene of white spot syndrome virus (wssv) and likely to have an important role in viral pathogenesis. the construct was used singly and in combination with other similar constructs designed against vp28 and vp19. a total of 6 treatments, t1 (picp11-lh; 35 μg), t2 (pvp28-lh; 35 μg), t3 (pvp28-lh and pvp19-lh; 17.5 μg each), t4 (pvp28-lh a ...	2011	23637487
high throughput fabrication of disposable nanofluidic lab-on-chip devices for single molecule studies.	an easy method is introduced allowing fast polydimethylsiloxane (pdms) replication of nanofluidic lab-on-chip devices using accurately fabricated molds featuring cross-sections down to 60 nm. a high quality master is obtained through proton beam writing and uv lithography. this master can be used more than 200 times to replicate nanofluidic devices capable of handling single dna molecules. this method allows to fabricate nanofluidic devices through simple pdms casting. the extensions of yoyo-1 s ...	2012	23898358
spinal anaesthesia for caesarean section: plain vs hyperbaric bupivacaine.	to compare the clinical characteristics of sensory and motor block as well as haemodynamic stability using plain and hyperbaric bupivacaine in spinal anaesthesia for caesarean section.	2012	23862255
the effect of n-3 long chain fatty acids supplementation on plasma peroxisome proliferator activated receptor gamma and thyroid hormones in obesity.	peroxisome proliferator-activated receptor gamma (ppar γ) is a transcription factor, which is abundantly expressed in adipose tissue and has a direct link to adiposity. it seems that long-chain polyunsaturated fatty acids (lc-pufas) can regulate ppar γ expression. the purpose of this study was to investigate the effects of n-3lc pufa supplementation on plasma levels of ppar γ and thyroid hormones in obesity.	2012	23825994
strengthening socio-emotional competencies in a school setting: data from the pyramid project.	development of socio-emotional competencies is key to children's successful social interaction at home and at school.	2012	23822531
[amyloid polyneuropathies--biochemical and genetic aspects].	familial amyloid polyneuropathies (fap) are among the most frequent hereditary amyloidoses. these are serious, most often fatal diseases with autosomal dominant inheritance. fap can be caused by mutations in four genes, namely those encoding transthyretin, al-apoliprotein, gelsolin, and beta-2 microglobulin. transthyretin is a tetramer composed of four identical subunits linked by non covalent bonds and bearing binding sites for thyroxine (t4) and retinol-binding protein (rbp). more than 120 tra ...	2012	23815016
effects of natural bioactive products on the growth and ginsenoside contents of panax ginseng cultured in an aeroponic system.	this study was conducted to evaluate the effects of natural bioactive products such as manda enzyme (t1), yangmyeongwon (t2), effective microorganisms (t3), and kelpak (t4) on the growth and ginsenoside contents of panax ginseng cultured in an aeroponic system using a two-layer vertical type of nutrient bath under natural light conditions. the growth of ginseng plants showed specific characteristics according to the positions in which they were cultured due to the difference of light transmittan ...	2012	23717147
the effect of red ginseng extract on inflammatory cytokines after chemotherapy in children.	ginseng has been used as an herbal medicine, widely used in asian countries, for long time. recently, beneficial effects for immune functions of korean red ginseng (krg) have been reported in adults. this study was performed to investigate the effects of ginseng on immune functions in children after cessation of chemotherapy or stem cell transplantation for advanced cancer. thirty patients, who were diagnosed and treated for leukemia and solid cancer at the department of pediatrics and adolescen ...	2012	23717140
congenital hypothyroidism screening program in turkey: a local evaluation.	it was aimed to evaluate the national congenital hypothyroidism program in terms of thyroid-stimulating hormone (tsh) cut-off level, frequency of cases that required treatment and the stages before treatment in the kocaeli district area. this research was performed with the contribution of kocaeli university medical faculty, pediatric endocrinology department, and the kocaeli local health district. 25,188 babies born in 2009 were evaluated. the previous laboratory data including heel prick sampl ...	2012	23692784
[frequency of subclinical thyroid problems among women during the first trimester of pregnancy].	thyroid hormones play an important role in fetal neural and cognitive development. therefore thyroid abnormalities should be detected and treated early during pregnancy.	2012	23677185
evaluation of the seventh edition of the american joint committee on cancer tumour-node-metastasis (tnm) staging system for patients undergoing curative resection of hepatocellular carcinoma: implications for the development of a refined staging system.	this study aimed to evaluate the seventh edition of the american joint committee on cancer (ajcc) tumour-node-metastasis (tnm) staging system and to compare its efficacy with those of the fifth and sixth editions of the ajcc staging system and the tnm staging system defined by the liver cancer study group of japan.	2012	23659567
early adiposity rebound and obesity in children with congenital hypothyroidism.	earlier adiposity rebound (ar) is correlated with obesity. our goal is to examine rates of obesity and ar in congenital hypothyroidism (cht) and analyze the risk factors of obesity.	2012	23590955
dyslipidemia in subclinical hypothyroidism and the effect of thyroxine on lipid profile.	subclinical hypothyroidism (sh) has a prevalence between 4% and 10.5% in various studies. the burden of sh in india is expected to increase with increasing iodine sufficiency. studies have shown conflicting results concerning not only the degree of lipid changes in sh but also the effect of thyroxine substitution therapy. indian studies on dyslipidemia in sh and the effect of thyroxine on lipid profile are currently lacking.	2012	23565423
a case of simultaneous occurrence of graves' disease and hashimoto's thyroiditis.	simultaneous occurrence of hashimoto's thyroiditis (ht), and graves' disease (gd) is rare.	2012	23565420
cretinism revisited.	cretinism is a condition of severely stunted physical and mental growth due to untreated congenital hypothyroidism. it has been largely eliminated in the developed world, though we still continue to see cases in india.	2012	23565419
empty sella syndrome - beyond being an incidental finding.	empty sella is characterized by the herniation of the subarachnoid space within the sella, which is often associated with some degree of flattening of the pituitary gland. this study was undertaken to evaluate the clinical and hormonal profile in patients with empty sella.	2012	23565413
plurihormone secreting pituitary macroadenoma masquerading as thyrotoxicosis: clinical presentation and diagnostic challenges.	thyroid stimulating hormone (tsh) secreting adenomas are the rarest type of pituitary adenomas (1:1000000 in the population; 0.2- 2.8% of adenomas). plurihormonal thyrotropic adenomas are even rarer usually having cosecretion of growth hormone (gh) and prolactin. we report perhaps for the first time, tsh, gh, adrenocorticotrophic hormone (acth) and gonadotropins secreting pituitary macroadenoma diagnosed in a 40 year lady presenting with features of thyrotoxicosis for 5 months, amenorrhea for 3 ...	2012	23565411
thyroid disorders in pregnancy.	thyroid disorders are common in pregnancy and the most common disorder is subclinical hypothyroidism. due to the complex hormonal changes during pregnancy, it is important to remember that thyroxine requirements are higher in pregnancy. according to recent american thyroid association (ata) guidelines, the recommended reference ranges for tsh are 0.1 to 2.5 miu/l in the first trimester, 0.2 to 3.0 miu/l in the second trimester, and 0.3 to 3.0 miu/l in the third trimester. maternal hypothyroidism ...	2012	23565370
hemolysis in extracorporeal circulation: relationship between time and procedures.	extracorporeal circulation (ec) is very important in cardiac surgery but causes significant damage to the blood, including hemolysis.	2012	23515726
laparoscopic excision of local recurrence of renal cell carcinoma.	to report a single center's experience with laparoscopic excision of local recurrence of renal cell carcinoma.	2012	23484571
[effects of electro-acupuncture combined general anesthesia on myocardial injury of high blood sugar patients with coronary heart disease in the perioperative phase].	to investigate the effects of electro-acupuncture (ea) combined general anesthesia on myocardial injury of high blood sugar patients with coronary heart disease (chd) in the perioperative phase.	2012	23469596
colorimetric assay for t4 polynucleotide kinase activity based on the horseradish peroxidase-mimicking dnazyme combined with λ exonuclease cleavage.	t4 polynucleotide kinase (pnk) plays a critical role in various cellular events. here, we describe a novel colorimetric strategy for estimating the activity of pnk and screening its inhibitors taking advantage of the efficient cleavage of λ exonuclease and the horseradish peroxidase-mimicking dnazyme (hrpzyme) signal amplification. a label-free hairpin dna with the sequence of hrpzyme was utilized in the assay. the 5'-hydroxyl terminal of the hairpin dna was firstly phosphorylated in the presenc ...	2012	23427805
traditional chinese medicine etiology and pathogenesis of acquired immune deficiency syndrome in simian immunodeficiency virus-infected chinese rhesus macaques.	to investigate the traditional chinese medicine (tcm) etiology and pathogenesis of acquired immune deficiency syndrome (aids) by 18-month observation of chinese rhesus macaques infected with simian immunodeficiency virus (siv) mac239.	2012	23427397
higher dose of methimazole causes frequent adverse effects in the management of graves' disease in children and adolescents.	methimazole (mmi) is used as a first-line antithyroid drug in children and adolescents with graves' disease (gd). the aim of this study was to evaluate the correlation between the initial dose of mmi and the clinical course of gd after treatment.	2012	23426814
tsh suppression after intravenous glucocorticosteroid administration in preterm infants.	reports have described that, in adults, steroids suppress thyroid-stimulating hormone (tsh) and triiodothyronine (t3) and might suppress thyroxine (t4). no data have been reported for thyroid hormone changes before or after administration of glucocorticoid in preterm infants.	2012	23426812
in congenital hypothyroidism, an initial l-thyroxine dose of 10-12 μg/kg/day is sufficient and sometimes excessive based on thyroid tests 1 month later.	current guidelines recommend an initial l-thyroxine (l-t4) dose of 10-15 μg/kg/day for the treatment of congenital hypothyroidism (ch). we analyzed our data for the treatment outcome at 1 month after we noted a frequent overtreatment even at the lower end of this dose range.	2012	23426811
surgical treatment of lumbar vertebral collapse in a patient with parkinson's disease: a case report.	parkinson's disease (pd) frequently develops postural abnormalities including extreme neck flexion and trunk flexion. patients with pd sometimes have osteopenia and vertebral deformity due to the destruction of fragile bone can be also associated with the spinal deformity. surgical treatment for these patients is very difficult. we encountered a patient with pd presenting severe trunk sagittal and frontal deformity. the patient had cauda equina syndrome due to progressive vertebral collapse of t ...	2012	23412270
effects of treatment with l-thyroxin on glucose regulation in patients with subclinical hypothyroidism.	we examined effects of treatment with 1-thyroxin on glucose regulation in patients with subclinical hypothyroidism.	2012	23409511
the role of selenium in cadmium toxicity: interactions with essential and toxic elements.	1. the study was part of a project designed to investigate if organic selenium (se) can ameliorate the toxic effects of cadmium (cd). the main objective of the present study was to investigate, in the chicken, the interactions between se, cd and the following elements: sb, ca, cr, co, cu, fe, pb, mg, mn, mo, ni, v and zn. 2. a total of 300 1-d-old chickens (broilers) were randomly distributed among 4 dietary treatments with 5 replicate pens per treatment. in t1, chickens were fed on a diet with ...	2012	23398427
epidemiology and clinical characteristics of larynx and hypopharynx carcinoma: a comparative study in the hainaut and review of the literature.	the epidemiology and clinical picture of laryngeal and hypopharyngeal carcinomas have changed significantly in the past 50 years. the aim of this study was to analyze selected epidemiological and clinical characteristics of laryngeal and hypopharyngeal carcinoma.	2012	23397823
new modalities to treat laryngeal cancer.	early laryngeal cancer comprises t1 and t2 stages of the disease. open functional operations achieve local control of the disease in 90-95% of t1 patients and in 70-90% of t2 patients. primary rt achieves local control in 85-94% of t1 tumors and in 70-80% of patients with t2 tumors. introduction of endoscopic laser surgery resulted in further popularization of preservation laryngeal surgery, whereby equally successful treatment results are achieved with minimal invasiveness. quality of voice is ...	2012	23397746
[t∧g: an elementary integrated prognostic system for renal carcinoma n0 m0].	introduction: 25-30% of patients with renal cell carcinoma (rcc) develop metastatic progression during follow up. for this reason many prognostic systems have been developed to try to predict the possibility of recurrence. unfortunately these systems are often complex in daily use. patient and methods: 1089 were selected from a total of 1985 patients undergoing surgery for renal cell cancer. we have excluded patients with a benign diagnosis, lymph node or distant metastases at diagnosis, with no ...	2012	23371278
the effect of protease and xylanase enzymes on growth performance and nutrient digestibility in finisher pigs.	two 2 × 2 factorial experiments were conducted to investigate the interaction between xylanase (0 vs. 200 mg/kg) and protease (0 vs. 200 mg/kg) enzyme supplementation on growth performance (exp. 1) and coefficient of ileal and total tract apparent digestibility in grower-finisher pigs (exp. 2). one hundred and twenty-eight individual fed pigs (bw = 34.2 kg; n = 32) were assigned to 1 of 4 dietary treatments: basal diet (t1), t1 + xylanase enzyme (t2), t1 + protease enzyme (t3), or t1 + xylanase ...	2012	23365384
the long-term regulation of food intake and body weight depends on the availability of thyroid hormones in the brain.	we evaluated the contribution of the thyroid hormones to the long-term maintenance of feeding behavior and body weight, while distinguishing their direct central effects from those resulting from the metabolic rate in the peripheral tissues.	2012	23391881
association between bipolar affective disorder and thyroid dysfunction.	bipolar affective disorder may be associated with alterations in thyroid function. a comprehensive thyroid assessment is important for assessing clinical and sub-clinical imbalances linked to a variety of mood disorders like bipolar affective disorder.	2012	23380316
assessment of left ventricular diastolic dysfunction in sub-clinical hypothyroidism.	adverse cardiovascular effect of hypothyroidism has been identified in many studies. early identification of patients with sub-clinical hypothyroidism may lead to early treatment and thereby favourable effect on cardiovascular morbidity and mortality.	2012	23378686
the effect of vitamin a supplementation on thyroid function in premenopausal women.	vitamin a and its retinoid derivates play an important role in regulation of normal growth and development. vitamin a has been shown to regulate thyroid hormone metabolism and inhibit thyroid-stimulating hormone (tsh) secretion via down regulation of tsh-β gene expression; however, the effect of vitamin a on thyroid function in obese individuals who are at higher risk of subclinical hypothyroidism is still unclear. in the present study we investigate the impact of vitamin a supplementation on th ...	2012	23378454
[study on mechanism of traditional chinese medicines reducing phlegm and resolving masses in treatment of goiter].	to discuss the mechanism of traditional chinese medicines reducing phlegm and resolving masses in treatment of iodine deficiency-induced goiter by observing the expression of growth factors and the balance-regulating mechanism of proliferation and apoptosis.	2012	23373220
advantages of voice reproduction and the development of a biomimetic self-regulating double-clack valve for a prosthesis of the larynx--a feasibility study.	the human larynx is a versatile organ. main functions are phonation, protection and regulation of the air ways. patients suffer severely from the diagnosis of a laryngeal carcinoma of the stages t3 and t4. in most cases this diagnosis will lead to a total laryngectomy, which is usually dissatisfying in the sense of postoperative rehabilitation. the postoperative consequences include the loss of the native voice, the loss of regular air ways via mouth and nose, sense of smell, and the inability t ...	2012	23366020
[a case of acute exacerbation of interstitial pneumonia after appendectomy managed with spinal anesthesia].	an 88-year-old woman was admitted with acute appendicitis. she had been treated with prednisolone and home oxygen therapy for interstitial pneumonia. her respiratory state on admission was grade 2 of hugh-jones' classification, and plasma kl-6 and sp-d levels were high. seven days after the admission, appendectomy was performed under spinal anesthesia. spinal anesthesia was initiated by injecting 0.5% hyperbaric bupivacaine 2.0ml into l3-4 interspace, and achieved block level was up to t4. durin ...	2012	23362773
[hypothyroidism incidence after multimodal treatment for laryngeal cancer].	hypothyroidism following total laryngectomy or radiotherapy treatment for laryngeal cancer is not a rare event, especially in advanced stages. there are no reports on the incidence of hypothyroidism in patients who received chemotherapy and radiotherapy. the objective of this study is to determine the incidence of thyroid dysfunction in a group of patients with laryngeal cancer who underwent surgery as sole treatment, total laryngectomy or radiotherapy alone, and patients with combined treatment ...	2012	23351449
[indication of chemoradiotherapy in patients with unresectable t4 breast tumors].		2012	23350460
association of inflammation with atrial fibrillation in hyperthyroidism.	the aim of this study was to evaluate the relationship between inflammation and development of atrial fibrillation (af) in patients with hyperthyroidism.	2012	23341838
unusual presentations of a girl with down syndrome: van wyk-grumbach syndrome.	van wyk-grumbach syndrome is a rare disease characterized by precocious puberty associated with prolonged hypothyroidism and multicystic enlarged ovaries. a 9-year-old girl with down syndrome visited our hospital for early menarche. at birth, she showed subclinical hypothyroidism [11.8 μg/dl of thyroxine (t4) and 6.05 μiu/ml of thyroid stimulating hormone (tsh)], but she had not been followed up in our clinic. on physical examination, pubertal tanner stage was breast ii and pubic hair i. laborat ...	2012	23329774
comparison of the anesthetic effects of intrathecal levobupivacaine + fentanyl and bupivacaine + fentanyl during caesarean section.	regional anesthesia techniques are increasingly preferred for caesarean section. the aim of the present study was to compare the anesthetic effects of levobupivacaine + fentanyl and bupivacaine + fentanyl on the mother and newborn during elective caesarean section under spinal anesthesia.	2012	23327030
analysis of reference interval and age-related changes in serum biochemistry and hematology in the specific pathogen free miniature pig.	we analyzed 72 items related to serum biochemistry and hematology in 85 specific pathogen-free (spf) seoul national university (snu) miniature pigs aged 1- to 36-months which originated from a minnesota miniature pig. almost all examined items were similar between male and female pigs. however, some items such as cr level, b/c ratio, c.r.f, ldh, lap and t4 were significantly different between male and female pigs (p<0.05). thirty four examined items showed age-related changes, and the significan ...	2012	23326285
isolation and genotyping of acanthamoeba strains from environmental sources in ahvaz city, khuzestan province, southern iran.	acanthamoeba spp. are free-living amoebae commonly found in the environmental sources such as water, soil, and air. this ubiquitous amoeba is the causative agent of amoebic keratitis (ak). the objective of the present study was to investigate the presence of acanthamoeba spp. in water and soil sources in ahvaz city, khuzestan province, southern iran.	2012	23323088
changes of subtests of wechsler memory scale and cognitive function in subjects with subclinical hypothyroidism following treatment with levothyroxine.	subclinical hypothyroidism has been reported to be associated with disturbed cognitive function. in this study, changes of subtests of the wechsler memory scale and memory quotient were investigated in subjects with subclinical hypothyroidism following treatment with levothyroxine. the aim of the study was a randomized double blind placebo-controlled clinical trial.	2012	23319987
[prevalence of thyroid abnormalities among psoriatic patients].	psoriasis is a chronic papulosquamous cutaneous disease. the etiology is unknown. several biochemical and immunological processes, which appear in patients with genetic predisposition, lead to enhanced proliferation of epidermal cells, and inflammation of the dermis. thyroid gland hormones cause an increase of epidermal growth factor level, which has an important role in keratinocyte proliferation, which may be involved in psoriasis disease.	2012	23316662
[pharyngocutaneous fistula following total laryngectomy].	pharyngocutaneous fistula (pcf) is the most common complication after total laryngectomy.	2012	23306575
radioiodine thyroid remnant ablation after recombinant human thyrotropin or thyroid hormone withdrawal in patients with high-risk differentiated thyroid cancer.	to supplement limited relevant literature, we retrospectively compared ablation and disease outcomes in high-risk differentiated thyroid carcinoma (dtc) patients undergoing radioiodine thyroid remnant ablation aided by recombinant human thyrotropin (rhtsh) versus thyroid hormone withdrawal/withholding (thw). our cohort was 45 consecutive antithyroglobulin antibody- (tgab-) negative, t3-t4/n0-n1-nx/m0 adults ablated with high activities at three referral centers. ablation success comprised negati ...	2012	23304637
identifying patients who may be candidates for a clinical trial of salvage accelerated partial breast irradiation after previous whole breast irradiation.	background and objectives. accelerated partial breast irradiation (apbi) has been proposed as an alternative to salvage mastectomy for patients with ipsilateral breast tumor recurrence (ibtr) after prior breast conservation. we studied factors that are associated with a more favorable local recurrence profile that could make certain patients eligible for apbi. methods. between 1980 and 2005, 157 stage 0-ii breast cancer patients had an ibtr treated by mastectomy. clinical and pathological featur ...	2012	23304530
headache as the sole symptom of nasopharyngeal carcinoma and its clinical implications.	this study aimed to investigate the clinical features of npc presenting with headache as the primary or sole symptom.	2012	23304077
[salvage central neck dissection for papillary thyroid cancer].	to evaluate the salvage central neck dissection (cnd) for papillary thyroid cancer in the patients with suspicious residual positive lymph nodes in the central compartment.	2012	23302163
improved sensitivity for long-distance measurements in biomolecules: five-pulse double electron-electron resonance.	we describe significantly improved long-distance measurements in biomolecules by use of the new multipulse double electron-electron spin resonance (deer) illustrated with the example of a five-pulse deer sequence. in this sequence, an extra pulse at the pump frequency is used compared with standard four-pulse deer. the position of the extra pulse is fixed relative to the three pulses of the detection sequence. this significantly reduces the effect of nuclear spin-diffusion on the electron-spin p ...	2012	23301118
[iodine and thyroid gland with or without nuclear catastrophe].	iodine, as a trace element, is a necessary and limiting substrate for thyroid gland hormone synthesis. it is an essential element that enables the thyroid gland to produce thyroid hormones thyroxine (t4) and triiodothyronine (t3). synthesis of thyroid hormones and iodine metabolism. three iodine molecules are added to make triiodothyronine, and four for thyroxine - the two key hormones produced by the thyroid gland. iodine deficiency the proper daily amount of iodine is required for optimal thyr ...	2012	23297615
[analysis of mosaic expression of the nptii gene in transgenic tobacco plant lines contrasting in mosaicism].	differences in the frequency of occurrence of plants with the mosaic phenotype between the nu5 and nu6 lines of transgenic tobacco (nicotiana tabacum) plants remained irrespective of the allelic state of the nptii marker gene. transition of the nptii gene from the hemizygous state (t3) to the homozygous state (t4) was accompanied by an increase in the frequency of mosaics in both lines. transition from the homozygous state (t4) into the hemizygous state (f1) resulted in a further increase in the ...	2012	23297483
congenital hypothyroidism: a review of the risk factors.	this study was aimed to evaluate the situation of congenital hypothyroidism (ch) in guilan using the screening program and determine the correlation of ch with birth weight, gestational age and seasonality. during 2006 to 2010, in guilan province, neonatal screening for ch by measurement of serum tsh level was performed in 3-5 days after birth. all neonates with tsh level ≥ 5mu/l were referred to endocrinologists and serum tsh, t3 and t4 were measured. based on public health data and profiles, t ...	2012	23292624
distribution of contrast medium epidurally injected at thoracic and lumbar vertebral segments.	the epidural distribution of iohexol (0.2 ml/kg) administered at thoracic vertebrae (thoracic group) and lumbar vertebrae (lumbar group) was compared by computed tomographic (ct) epidurography in dogs. the total spread of iohexol was similar between the 2 groups upon reaching a similar cranial level. the maximal ct values were higher at the c7/t1 and t4/t5 levels in thoracic group, but they were higher at the t13/l1 and l4/l5 levels in lumbar group (p<0.05). this result suggests that the distrib ...	2012	23292108
detection of t4 polynucleotide kinase activity with immobilization of tio2 nanotubes and amplification of au nanoparticles.	determination of nucleotide kinase activity is valuable due to its importance in regulating nucleic acid metabolism. herein, we describe a strategy for simply and accurately determining nucleotide kinase activity by tio2 nanotubes mediated signal transition and au nanoparticles amplification. in this method, dna containing 5'-hydroxyl group is self-assembled onto a gold electrode and used as a substrate for t4 polynucleotide kinase (pnk). by the specific immobilization affinity of tio2 nanotubes ...	2012	23291616
[subcarinal lymph node metastasis and strategy of lymphadenectomy in thoracic esophageal carcinoma].	to assess the metastatic frequency of subcarinal lymph nodes of thoracic esophageal carcinoma and its influencing factors, in order to determine the adequate range of lymph node dissection during esophagectomy.	2012	23291134
association between osteopontin and egfr expression with clinicopathological parameters in hepatocellular carcinoma.	osteopontin (opn) and epidermal growth factor receptor (egfr) are important factors associated with tumor progression, invasion and metastasis in humans. the aim of this study was to assess the correlation of opn and egfr expression with hepatocellular carcinoma (hcc) progression. expression of opn and egfr was assessed by immunohistochemistry in 100 hcc specimens. immunostaining scores (0 to 400) were calculated from the percentage of cells (0 to 100) at each immunostaining intensity and the im ...	2012	23286449
[immunological characteristics in subjects with heart connective tissue dysplasia depending on thyroid hormone levels and vegetative dysfunction].	patients with heart connective tissue dysplasia (hctd) are known to be subject to infectious and inflammatory diseases due to peculiarities of their immune system. we studied 181 patients with hctd depending on thyroid hormone levels and vegetative dysfunction. hctd was shown to be associated with a significant decrease of igm levels and increase of circulating immune complexes. the igg level in patients with mitral valve prolapse (mvp), anomalous chord localization, and combination of mpv and t ...	2012	23285764
[the influence of subclinical thyroid dysfunction on cardiac hemodynamic and electrophysiological parameters in patients with coronary heart disease and paroxysmal atrial fibrillation].	the study included 58 patients with chd and paroxysmal atrial fibrillation divided into 2 groups depending on thyroid hormone and thyrotropin levels. group 1 was comprised of 24 patients with subclinical hypothyroidism, group 2 of 18 ones with subclinical hyperthyroidism. control group consisted of l6 patients with chd, paroxysmal atrial fibrillation and normal thvroid function. it was shown that patients with chd, paroxysmal atrial fibrillation and subclinical thyrotoxicosis had t3 and t4 level ...	2012	23285759