Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| Dynamics of mutator and antibiotic-resistant populations in a pharmacokinetic/pharmacodynamic model of Pseudomonas aeruginosa biofilm treatment. | Biofilm growth, antibiotic resistance, and mutator phenotypes are key components of chronic respiratory infections by Pseudomonas aeruginosa in cystic fibrosis patients. We examined the dynamics of mutator and antibiotic-resistant populations in P. aeruginosa flow-cell biofilms, using fluorescently tagged PAO1 and PAOMS (mutator [mutS] derivative) strains. Two-day-old biofilms were treated with ciprofloxacin (CIP) for 4 days (t4) at 2 µg/ml, which correlated with the mutant prevention concentrat ... | 2011 | 21859941 |
| individualised isotoxic accelerated radiotherapy and chemotherapy are associated with improved long-term survival of patients with stage iii nsclc: a prospective population-based study. | background: individualised, isotoxic, accelerated radiotherapy (indar) allows the delivery of high biological radiation doses, but the long-term survival associated with this approach is unknown. methods: patients with stage iii nsclc in the netherlands cancer registry/limburg from january 1, 2002 to december 31, 2008 were included. results: patients (1002) with stage iii nsclc were diagnosed, of which 938 had t4 and/or n2-n3 disease. patients treated with curative intent were staged with fdg-pe ... | 2011 | 22100659 |
| a fate model of pathogenic viruses in a composting toilet based on coliphage inactivation. | a composting toilet using sawdust as a matrix has the potential to trap pathogens that might occasionally be contained in human feces. therefore, care should be taken when handling the sawdust. it should also be noted that pathogenic viruses tend to have stronger tolerance than pathogenic bacteria. the fates of several species of coliphages, t4, lambda, qbeta and ms2, in sawdust were investigated as a viral model. the fates of coliphages were significantly different among them, and they changed ... | 2011 | 22125914 |
| Effect of ELTGOL on Mucus Clearance in Stable Patients With Chronic Bronchitis. | BACKGROUND: Slow expiration with glottis opened in lateral posture (ELTGOL) has been used in clinical practice to improve mucus clearance from peripheral airways. The purpose of this crossover study was to evaluate the effect of ELTGOL on mucus clearance of right and left lungs, especially of peripheral lung areas, in stable patients with chronic bronchitis. METHODS: Twelve 45 to 75 year-old patients (10 of whom had mild to moderate Chronic Obstructive Pulmonary Disease (COPD) according to GOLD) ... | 2011 | 22005107 |
| A meta-analysis of D1 versus D2 lymph node dissection. | BACKGROUND: Surgery is the only curative treatment for patients with gastric cancer. However, the extent of lymph node dissection is still debated. Therefore, with the publication of newer trial results, we conducted an updated meta-analysis of D1 versus D2 randomized controlled trials comparing outcomes. METHODS: Systematic searches were conducted using Medline, Embase, and the Cochrane Central Register of Contr ... | 2011 | 22138927 |
| Stage IV Colorectal Cancers: An Analysis of Factors Predicting Outcome and Survival in 728 cases. | INTRODUCTION: Stage IV colorectal cancer (CRC) is a heterogeneous disease with many treatment options. The optimum management algorithm is yet to be established. The aim of this study was to evaluate the prognostic factors of survival and to determine the operative benefit of resection of the primary tumour followed by chemotherapy. METHODS: Seven hundred twenty-eight consecutive patients who presented with stage ... | 2011 | 22009464 |
| completely laparoscopic versus open gastrectomy for early and advanced gastric cancer: a matched cohort study. | introduction: the application of laparoscopic gastric surgery has rapidly increased for the treatment of early gastric cancer. however, laparoscopic gastrectomy for advanced tumor remains controversial, particularly in terms of oncologic outcomes. this study was designed to compare 3-year survival of laparoscopic versus open curative gastrectomy in early and advanced gastric cancer. methods: this was a retrospect ... | 2011 | 22011940 |
| agreement between semi-automatic radiographic morphometry and genant semi-quantitative method in the assessment of vertebral fractures. | semi-automatic morphometry is highly reproducible and not time intensive; however, no study has evaluated agreement between semi-automated morphometric methods and the genant semi-quantitative method performed as a rule by radiologists. our study shows substantial agreement between both methods; however, semi-automatic morphometry upgrades mild deformities and overestimates the prevalence of fractures. introduction: the aim of this st ... | 2011 | 22170523 |
| earthworms repair h2o2-induced oxidative dna adducts without removing uv-induced pyrimidine dimers. | ultraviolet (uv) radiation is a natural insult to various organisms. earthworms, although possessing similar biomolecules to those in mammalian skin, do not suffer from skin cancer nor any other types of cancer as humans do. however, little is known about the molecular mechanism of the earthworm's tolerance to uv. in this study, we evaluated the genotoxicity of uv and the capacity of earthworm cell to repair uv-induced damage. the t4 uv endonuclease uv-incorporated comet assay was used to examin ... | 2011 | 22021692 |
| Sensitive and rapid screening of T4 polynucleotide kinase activity and inhibition based on coupled exonuclease reaction and graphene oxide platform. | Phosphorylation of DNA with 5'-hydroxyl termini plays a critical role in a majority of normal cellular events, including DNA recombination, DNA replication, and repair of DNA during strand interruption. Determination of nucleotide kinase activity and inhibition is under intense development due to its importance in regulating nucleic acid metabolism. Here, by using T4 polynucleotide kinase (PNK) as a model, which plays an essential role in cellular nucleic acid metabolism, particularly in the cel ... | 2011 | 22026510 |
| increased frequency of follicular helper t cells in patients with autoimmune thyroid disease. | context:follicular helper t (tfh) cells exert an important role in the autoimmune diseases.aim:our study aimed to explore the role of tfh cells in patients with autoimmune thyroid disease (aitd).design:tfh cell is a new subset regulating the antibody production of b cell. previous studies implicated cd4(+)cxcr5(+)icos(high) or cd4(+)cxcr5(+)pd-1(high) as the markers of circulating tfh cells. sixty-five patients with aitd and 30 healthy controls were enrolled in the current study. the percentages ... | 2011 | 22188745 |
| serum hormone and biochemical activity as biomarkers of mercury toxicity in the yellowfin seabream acanthopagrus latus. | this study was undertaken in two separate environmental and experimental conditions. the environmental test was carried out at creeks in the persian gulf and the experimental test was undertaken in seawater re-circulatory tanks. mercury concentrations were determined using a standard cold vapour atomic absorption method. serum enzymes were determined with diagnostics infinity reagent kit. serum glucose and total protein were measured photometrically. serum hormones were assayed using diagnostic ... | 2011 | 21911425 |
| central neuropeptide y infusion and melanocortin 4 receptor antagonism inhibit thyrotropic function by divergent pathways. | weight loss inhibits thyrotropic function and reduces metabolic rate, thereby contributing to weight regain. under negative energy balance there is an increase in the hypothalamic expression of both neuropeptide y (npy) and agouti related peptide (agrp), the endogenous antagonist of melanocortin 4 (mc4) receptors. both npy and mc4 receptor antagonism reduce thyrotropic function centrally, but it is not known whether these pathways operate by similar or distinct mechanisms. we compared the time-c ... | 2011 | 21862125 |
| Sex Differences in Spinal Osteoarthritis in Humans and Rhesus Monkeys (Macaca mulatta). | STRUCTURED ABSTRACT.: Study Design. Retrospective study of male and female spinal osteoarthritis, characterized by lateral spine thoracolumbar radiographs, in humans and nonhuman primatesObjective. To characterize differences in prevalence and vertebral distribution of spinal osteoarthritis between men and women, between male and female macaques, and between the two phylogenetically related genera.Summary of Background Data. Naturally occurring spinal osteoarthritis manifests similarly in humans ... | 2011 | 22024896 |
| Impact of low-level thyroid hormone disruption induced by propylthiouracil on brain development and function. | The critical role of thyroid hormone (TH) in brain development is well-established. Evidence shows that severe deficiencies lead to significant neurological dysfunction. Much less information is available on more modest perturbations of TH on brain function. The present study induced varying degrees of developmental hypothyroidism by administration of low doses of the TH synthesis inhibitor, propylthiouracil (PTU 0, 1, 2, and 3 ppm) to the drinking water of pregnant rats. This regimen produced d ... | 2011 | 21964421 |
| retrospective computed tomography scan analysis of percutaneously inserted pedicle screws for posterior transpedicular stabilisation of the thoracic and lumbar spine: accuracy and complication rates. | structured abstract: study design. retrospective clinical data analysis.objective. to investigate the misplacement rate and related clinical complications of percutaneous pedicle screw insertion in the thoracic and lumbar spine.summary of background data. percutaneous insertion of cannulated pedicle screws has been developed as a minimally invasive alternative to the open technique during instrumented fusion procedures of the thoraco-lumbar spine. the reported rate of screw misplacement using op ... | 2011 | 22037528 |
| current surgical treatment of non-small-cell lung cancer. | when considering surgical treatment for non-small-cell lung cancer (nsclc), a distinction is made between early-stage disease (stages ia/b and iia/b), locoregionally advanced disease (stages iiia/b) and metastatic disease (stage iv). complete surgical resection of nsclc can provide good long-term outcome. surgery is considered the treatment of choice in patients with early-stage nsclc or patients with t3n1 disease. surgery for locoregionally advanced disease remains controversial. in specific ca ... | 2011 | 21999131 |
| Docetaxel plus 5-fluorouracil and cisplatin (DCF) induction chemotherapy for locally advanced borderline-resectable T4 esophageal cancer. | This study aimed to evaluate the efficacy of docetaxel plus 5-fluorouracil and cisplatin (DCF) induction chemotherapy for locally advanced borderline-resectable T4 esophageal cancer. | 2011 | 21965775 |
| Lymph node dissection in renal cell carcinoma. | Although lymphadenectomy (lymph node dissection [LND]) is currently accepted as the most accurate and reliable staging procedure for the detection of lymph node invasion (LNI), its therapeutic benefit in renal cell carcinoma (RCC) still remains controversial. | 2011 | 21940096 |
| Subclinical hypothyroidism in pregnancy: intellectual development of offspring. | The effects of maternal subclinical hypothyroidism (M-SCH) on the neuropsychological development of the offspring are not clear. We evaluated the intellectual development of children of mothers who had M-SCH during the pregnancy for these children. | 2011 | 21943136 |
| Risk for progression to overt hypothyroidism in an elderly Japanese population with subclinical hypothyroidism. | Few population-based studies report the changes with time in thyroid function tests in patients with subclinical hypothyroidism. We compared the risk for developing overt hypothyroidism in patients with subclinical hypothyroidism and euthyroid controls from the same population of elderly Japanese. We also sought associations of selected parameters with the development of overt hypothyroidism in the subclinical hypothyroid and euthyroid groups. | 2011 | 21877935 |
| effect of selenium, zinc, and copper supplementation on blood metabolic profile in male buffalo (bubalus bubalis) calves. | twenty male buffalo calves (15 months, 200.2 ± 9.75) were divided into four groups of five animals in each and fed diets without (t1) or supplemented with 0.3 ppm selenium (se) + 40 ppm zinc (zn) (t2), 0.3 ppm se + 40 ppm zn + 10 ppm copper (cu) (t3), and 40 ppm zn + 10 ppm cu (t4) for 120 days, during which blood samples were collected on days 0, 40, 80, and 120. concentrations of glucose, total protein, albumin, globulin, urea, uric acid, and creatinine were similar in all the four groups. the ... | 2011 | 21947859 |
| The number of high-risk factors is related to outcome in stage II colonic cancer patients. | A subgroup of stage II colonic cancer patients are considered to be at high-risk for recurrent/metastatic disease based on 1) tumour obstruction/perforation 2) <10 lymph nodes 3) T4 lesions and 4) lymphangio-invasion. Their prognosis is regarded as comparable to stage III (T1-4N+M0) colonic cancer and it is therefore strongly advised to treat them with adjuvant chemotherapy. The purpose of this study was i) to determine the magnitude of prognostic significance of the conventional high-risk facto ... | 2011 | 21930361 |
| Competitive, non-competitive, and mixed format cleavable tag immunoassays. | Immunoassays are one of the most useful diagnostic techniques in disease assessment, drug metabolite analysis, and environmental applications due largely in part to the selectivity and sensitivity provided by antibody-antigen interactions. Here, a multiplexed immunoassay termed cleavable tag immunoassay (CTI) was performed in competitive, non-competitive, and mixed formats for the analysis of proteins and small molecule biomarkers of inflammation and tissue damage. Microchip capillary electropho ... | 2011 | 21970819 |
| Myxedema coma: a new look into an old crisis. | Myxedema crisis is a severe life threatening form of decompensated hypothyroidism which is associated with a high mortality rate. Infections and discontinuation of thyroid supplements are the major precipitating factors while hypothermia may not play a major role in tropical countries. Low intracellular T3 leads to cardiogenic shock, respiratory depression, hypothermia and coma. Patients are identified on the basis of a low index of suspicion with a careful history and examination focused on fea ... | 2011 | 21941682 |
| intensity-modulated radiotherapy combined with chemotherapy for the treatment of gastric cancer patients after standard d1/d2 surgery. | the purpose of the current study is to evaluate the efficacy and complications of concurrent chemoradiotherapy (ccrt) for the treatment of gastric cancer patients after d1/d2 surgery. | 2011 | 22105898 |
| a 5-year-old boy with atrophic autoimmune thyroiditis caused by thyroid-stimulation blocking antibodies. | a 5-year-old boy was presented for a growth disturbance, which was initially noted at 3 years of age. endocrinological testing identified severe hypothyroidism, defined by the following levels: tsh 990.5 microu/ml, f-t3 0.26 pg/ml, and f-t4 0.09 ng/dl. serum anti-thyroid peroxidase (tpo) antibodies were 158 iu/ml and serum thyroid-stimulation blocking antibodies (tsbab) levels were 82.1 iu/ml (normal range < 45.6). thyroid scintigraphy with 99mtc showed markedly decreased uptake, and magnetic re ... | 2011 | 21932608 |
| antimutator variants of dna polymerases. | evolution balances dna replication speed and accuracy to optimize replicative fitness and genetic stability. there is no selective pressure to improve dna replication fidelity beyond the background mutation rate from other sources, such as dna damage. however, dna polymerases remain amenable to amino acid substitutions that lower intrinsic error rates. here, we review these 'antimutagenic' changes in dna polymerases and discuss what they reveal about mechanisms of replication fidelity. pioneerin ... | 2011 | 21977975 |
| [sentinel lymph node biopsy as a new approach to colorectal cancer treatment]. | some concepts considering sentinel lymph node excision in colon and rectal carcinoma are presented in the paper. arguments pro and contra were exposed and interpret separately. the problem is still open. current knowledge indicates that lymphatic system in colon and rectum can be very different in many patients. there is no evidence that sentinel node biopsy in this group can be useful. in patients with advanced colorectal carcinoma (t3, t4 according to tnm classification) sentinel node biopsy c ... | 2011 | 22097185 |
| Management of the "violated neck" in the era of chemoradiation. | To determine if patients who have undergone an open neck biopsy (a "violated" neck) have improved disease control and survival with completion neck dissection. | 2011 | 21993776 |
| Evaluation of Thyroid Disorders During Head and Neck Radiotherapy by Using Functional Analysis and Ultrasonography. | PURPOSE: To evaluate thyroid function and vascular changes during radiotherapy for patients with head and neck cancer. METHODS AND MATERIALS: Fifty patients treated with primary or postoperative radiotherapy for various cancers in the head and neck region were prospectively evaluated. The serum samples (triiodothyronine [T3], thyroxine [T4], thyroid-stimulating hormone [TSH], free triiodothyronine [FT3], and free thyroxine [FT4]), the echo level of the thyroid gland, and color Doppler ultrasonog ... | 2011 | 22000746 |
| Prospective trial of chemotherapy-enhanced accelerated radiotherapy for larynx preservation in patients with intermediate-volume hypopharyngeal cancer. | BACKGROUND: Altered fractionation radiotherapy (RT) improves locoregional control in head and neck cancer without aggravation of late adverse events. To improve successful larynx-preservation rates in patients with resectable, intermediate-volume hypopharyngeal cancer, a prospective trial of chemotherapy-enhanced accelerated RT was conducted. METHODS: Patients with T2 to T4 hypopharyngeal cancer received 40 Gray (Gy)/4 weeks to the entire neck followed by boost RT administering 30 Gy/2 weeks (1. ... | 2011 | 22076936 |
| intensity-modulated radiotherapy for squamous cell carcinoma of the anal canal: efficacy of a low daily dose to clinically negative regions. | we aimed to assess outcomes of patients with anal cancer who underwent intensity-modulated radiotherapy (imrt) and received less than 1.80 gy/day. | 2011 | 21978568 |
| effects of the anti-thyroidal compound potassium-perchlorate on the thyroid system of the zebrafish. | the increasing pollution of aquatic habitats with anthropogenic compounds has led to various test strategies to detect hazardous chemicals. however, information on effects of pollutants in the thyroid system in fish, which is essential for growth, development and parts of reproduction, is still scarce. other vertebrate groups such as amphibians or mammals are well-studied; so the need for further knowledge especially in fish as a favored vertebrate model test organism is evident. modified early ... | 2011 | 22204988 |
| association of autonomously functioning thyroid nodules with hashimoto's thyroiditis: study on a large series of patients. | autonomously functioning thyroid nodules (aftns) associated with hashimoto's thyroiditis (ht) are rarely reported. this study evaluates the magnitude of such association, elaborating the clinical and biochemical characteristics of ht and aftn. | 2011 | 22068555 |
| Epidural anesthesia for repeat cesarean delivery in a parturient with Klippel-Feil syndrome. | A patient with Klippel-Feil syndrome, morbid obesity, and scoliosis required cesarean delivery. Her previous cesarean deliveries were performed under general anesthesia. She desired a regional technique. Following aspiration prophylaxis and placement of standard monitors, ultrasound was used to identify midline and L(2-3) interspace. Unintentional dural puncture occurred at 10 cm, with an inability to advance the catheter. On second attempt, an epidural catheter was placed easily. After negative ... | 2011 | 21897512 |
| Photocatalytic inactivation of bacteriophages by TiO2-coated glass plates under low-intensity, long-wavelength UV irradiation. | The International Organization for Standardization (ISO) was used to evaluate antibacterial activity by titanium dioxide (TiO(2)) photocatalysis since 2006. We evaluated photocatalytic inactivation of Qß and T4 bacteriophages induced by low-intensity, long-wavelength ultraviolet A (UVA; 0.1 mW cm(-2) and 0.001 mW cm(-2)) irradiation on a TiO(2)-coated glass plate using the ISO methodology. The results indicated that both bacteriophages were inactivated at 0.001 mW cm(-2) UVA. The intensity of UV ... | 2011 | 21931933 |
| Thyroid status two decades after salt iodisation: Country-wide data in school children from India. | Objective: Country-wide evaluation of thyroid disorders in school children following two decades of universal salt iodisation (USI) has not been carried out till date.The present study was planned with aim to assess thyroid status of school children two decades after launch of USI program. Design: Population survey Patients: We collected data from 25 schools in 19 cities across five different geographical zones of India. Those childrenwho were evaluated for anthropometry, goitre status by p ... | 2011 | 22142266 |
| suppression of ns3 and mp is important for the stable inheritance of rnai-mediated rice stripe virus (rsv) resistance obtained by targeting the fully complementary rsv-cp gene. | rice stripe virus (rsv) is a viral disease that seriously impacts rice production in east asia, most notably in korea, china, and japan. highly rsv-resistant transgenic japonica rice plants were generated using a dsrnai construct designed to silence the entire sequence region of the rsv-cp gene. transgenic rice plants were inoculated with a population of viruliferous insects, small brown planthoppers (sbph), and their resistance was evaluated using elisa and an infection rate assay. a correlatio ... | 2011 | 22134721 |
| Another 60 years in electron microscopy: development of phase-plate electron microscopy and biological applications. | It has been six decades since the concept of phase-plate electron microscopy was first reported by Boersch, but an experimental report on a phase plate with a theoretically rational performance has only recently been released by a group including the present author. Currently, many laboratories around the world are attempting to develop a wide range of phase plates to enhance the capabilities of transmission electron microscopy. They are reporting not only advantages of their own developments bu ... | 2011 | 21844600 |
| helicobacter pylori-negative gastric cancer in south korea: incidence and clinicopathologic characteristics. | it is difficult to determine the exact incidence rate of helicobacter pylori (h. pylori) infection-negative gastric cancer (hpin-gc) because h. pylori detection rates decrease with the progression of gastric atrophy and intestinal metaplasia. the aim of this study was to evaluate the incidence and clinicopathologic characteristics of hpin-gc in south korea. | 2011 | 21923684 |
| anaesthesia management for thyroidectomy in a non-euthyroid patient following cardiac failure. | a 24-year-old male thyrotoxic student of a tertiary institution had thyroidectomy in the presence of a persistently elevated thyroxine (t4) and tri-iodothyronine (t3) levels. he was initially managed for hypertension at a private hospital before he was referred to our hospital for expert management. he had symptoms of thyrotoxicosis three years before presentation at our hospital. physical examination revealed bilateral anterior neck masses and a diagnosis of toxic goitre was made. the serum t3 ... | 2011 | 22248956 |
| tsh neurosecretory dysfunction (tsh-nd) in down syndrome (ds): low risk of progression to hashimoto's thyroiditis. | patients with down syndrome (ds) often have elevated tsh (hypothalamic origin), which is called tsh neurosecretory dysfunction (tsh-nd). in these cases, there is slight elevation in tsh (5-15 µui/ml), with normal free t4 and negative thyroid antibodies (ab). | 2011 | 22218446 |
| [myoepithelial carcinoma of salivary glands: a clinical analysis of 13 cases]. | this study retrospectively analyzed the clinical data of 13 patients with myoepithelial carcinoma of salivary glands for improving the accuracy of diagnosis and treatment outcome. | 2011 | 22241311 |
| treatment of hypothyroidism due to iodine deficiency using daily powdered kelp in patients receiving long-term total enteral nutrition. | we investigated thyroid function and urinary iodine concentration (uic) in seven patients with severe motor intellectual disabilities. all seven received total enteral nutrition (ten) for more than three years with a daily iodine intake of less than 20 µg. they were diagnosed as hypothyroidism due to iodine deficiency (hid) because of high tsh levels (7.6-82.3 µiu/ml), lower free t4 (ft4 0.4-1.5 ng/dl), negative anti-thyroid antibodies (anti-thyroglobulin antibody, anti-thyroidal peroxidase anti ... | 2011 | 23926395 |
| nutritional and toxicological assessment of white-rot fermented animal feed. | the fungal fermented wheat straws as animal feeds have been evaluated for its toxicological and nutritional status in male rats (holtzman strain). digestibility of dry matter and other nutrients as well as fiber fractions were found significantly higher (p < 0.05) in straw fermented with either ganoderma sp. rckk02 (t3) or crinipellis sp. rck-1 (t4) than unfermented straw (t1) or straw fermented with pycnoporus cinnabarinus (t2). the aflatoxin b1, b2, g1 and g2 were either absent or present in p ... | 2011 | 23729880 |
| changes of serum trace elements, afp, cea, sf, t3, t4 and igf-ii in different periods of rat liver cancer. | based on liver cancer model built in sd rats, the contents of trace elements (cu, fe, zn, ca and mg), afp, cea, sf, th and igf-ii in serum were measured at different stages to explore the molecular changes during the rat liver cancer development. | 2011 | 23357927 |
| [viability and efects of the probiotic lactobacillus aracaseissp aracasei in chilean low-fat gauda cheese]. | the objective of this study is to infer the survival of the probiotic lactobacillus paracasei ssp paracasei added during the processing of low-fat gouda cheese, during the maturation (21 days) and the commercialization (14 days), in order to see the influence that this organism has on the quality of the product. the treatments were: ti (control): gouda with normal fat content; t2: low fat gouda cheese (qgs) t3: qgs, with additional probiotic added with the initial culture; t4: qgs, with the prob ... | 2011 | 23094525 |
| expression of p-akt and p-mtor in a large series of bronchopulmonary neuroendocrine tumors. | bronchopulmonary neuroendocrine tumors (bp-nets) are separated into four subgroups: typical carcinoid tumor (tc), atypical carcinoid tumor (ac), large-cell neuroendocrine carcinoma (lcnec) and small-cell lung carcinoma (sclc). the signaling pathway involving akt/mammalian target of rapamycin (mtor) is crucial to the regulation of cell growth, proliferation and survival, and is frequently activated in human cancers. consequently, mtor is considered an attractive target for anticancer agents. the ... | 2011 | 22977576 |
| subclinical hypothyroidism in childhood obesity and its correlation with lipoproteins. | there is an ongoing debate regarding the influence of subclinical hypothyroidism on body mass index. the objectives of the study were (i) to determine whether levels of thyroid stimulating hormone (tsh) are elevated in obese children, (ii) to compare the serum levels of triiodothyronine (t3) and thyroxine (t4) in obese with non-obese and (iii) to examine the association of subclinical hypothyroidism with lipoproteins and body mass index. | 2011 | 22783686 |
| chemoradiation in advanced head and neck cancers: a comparison of two radiosensitizers, paclitaxel and cisplatin. | to compare the locoregional control rates, survival outcome and toxicity profiles between two groups of patients of squamous cell carcinoma (scc) of head and neck (stage iii & iv) receiving concomitant chemo-radiotherapy with paclitaxel and cisplatin. a prospective study was done on 94 previously untreated patients of histopathologically proved squamous cell carcinoma of head and neck region-ajcc stage iii & iv (t3 & t4 with n0 -n3, m0) treated with concomitant chemoradiation. the patients were ... | 2011 | 22754800 |
| surgical treatment of papillary thyroid carcinoma. | papillary carcinoma accounts for 85% of differentiated thyroid cancers. we witness a yearly increased incidence and this is may be, in part, due to the increasing use of neck ultrasonography. certain histologic subtypes of papillary carcinoma have a worse prognosis related to vascular invasion, invasion into extrathyroidal tissues, extensive tumor necrosis and/or mitoses. adequate surgery is the most important treatment variable influencing prognosis, while radioactive iodine treatment, tsh supp ... | 2011 | 22746009 |
| successful bortezomib treatment in combination with dexamethasone and thalidomide for previously untreated epidural plasmacytoma. | epidural plasmacytoma is a rare clinical entity of plasma cell neoplasms. the optimal management of extra medullary plasmacytoma remains unclear, particularly for bulky masses. in this study, we report the case of a 35-year-old male who presented with the inability to walk, urinary incontinence and superficial and deep sensory disturbance. spinal magnetic resonance imaging revealed a large epidural mass compressing the spinal cord at the level of t2-t4. the patient underwent surgical t2-t4 verte ... | 2011 | 22740951 |
| copy number changes of crisp3 in oral squamous cell carcinoma. | the aim of this study was to identify tumor suppressor genes (tsgs) in oral squamous cell carcinoma (oscc) using whole-genome analysis of microarray technology and real-time quantitative polymerase chain reaction (qpcr). we applied whole-genome analysis of tsgs in the specimens from 3 patients of oscc by microarray technology. a total of 11 genes, crisp3, scgb3a1, agr2, pip, c20orf114, tff1, stath, azgp1, muc7, dmbt1 and loc389429, were found to be down-regulated, and 2, matrix metallopeptidase ... | 2011 | 22740859 |
| correlation of metabolism/hypoxia markers and fluorodeoxyglucose uptake in oral squamous cell carcinomas. | the objective of this study was to analyze the relationship between the uptake of (18)f-2-fluoro-2-deoxy-d-glucose (fdg) by positron emission tomography-computerized tomography (pet-ct) and glucose metabolism/hypoxia markers in oral squamous cell carcinoma (oscc). | 2011 | 22676927 |
| triiodothyronin, thyroxine and thyrotropin in vitiligo. | vitiligo is a common pigmentary disorder of the skin, affecting individuals globally. not only is this ailment psychologically incapacitating, it also has a high incidence of autoimmunity, signifying that its manifestations may be the portrayal of dysfunction of immune system. | 2011 | 22610860 |
| incidence of incidental carcinoma gall bladder in cases of routine cholecystectomy. | carcinoma of gall bladder is the most common malignancy of the billiary tract. most of the cases are diagnosed as an incidental case among patients undergoing cholecystectomy. | 2011 | 22610859 |
| failure patterns in patients with esophageal cancer treated with definitive chemoradiation. | local failure after definitive chemoradiation therapy for unresectable esophageal cancer remains problematic. little is known about the failure pattern based on modern-day radiation treatment volumes. we hypothesized that most local failures would be within the gross tumor volume (gtv), where the bulk of the tumor burden resides. | 2011 | 22565611 |
| how common is hypothyroidism after external radiotherapy to neck in head and neck cancer patients? | to identify the occurrence of clinical and subclinical hypothyroidism among head and neck cancer patients receiving radiation to the neck and to justify routine performing of thyroid function tests during follow-up. | 2011 | 22557780 |
| [functional assessment of the different types of anterior cruciate ligament plasty used at the xoco general hospital arthroscopy service]. | currently, anterior cruciate ligament lesions have an increased frequency; their management is predominantly surgical; there are several functional assessment systems. | 2011 | 22512111 |
| suppression of seizure by cathodal transcranial direct current stimulation in an epileptic patient - a case report -. | epilepsy is an intractable disease, though many treatment modalities have been developed. recently, noninvasive transcranial direct current stimulation (tdcs), which can change brain excitability, was introduced and has been applied for therapeutic purposes regarding epilepsy. a suppression of seizures was experienced by cathodal tdcs in a medication refractory pediatric epileptic patient. the patient was an 11-year-old female who had focal cortical dysplasia of the cerebral hemisphere. the pati ... | 2011 | 22506177 |
| craniofacial resection for sinonasal malignant tumors: statistical analysis of surgical outcome over 17 years at a single institution. | we present a retrospective analysis of surgical outcome of sinonasal malignant tumors. overall survival (os), disease-specific survival (dss), local control (lc), and disease-free survival (dfs) were calculated in 32 patients. prognostic factors for survival and functional outcomes were investigated. the median follow-up period was 70 months. at 5 years, os, dss, lc, and dfs rates were 0.722, 0.745, 0.851, and 0.707, respectively. prognostic factors for poor os were involvement of the frontal si ... | 2011 | 22470267 |
| concomitant chemoradiotherapy as a standard treatment for squamous cell carcinoma of the temporal bone. | we sought to characterize the effectiveness of concomitant chemoradiotherapy (ccrt) for patients with squamous cell carcinoma of the temporal bone. we performed a retrospective chart review of 14 patients with cancer of the temporal bone who were provided initial treatment in our hospital from december 2001 to november 2008. four patients with stage i tumors were treated by radiation therapy alone or with oral administration of s1. one patient with a stage ii tumor was treated by radiation thera ... | 2011 | 22451818 |
| single-molecule studies of viral dna packaging. | assembly of many dsdna viruses involves packaging of dna molecules into pre-assembled procapsids by portal molecular motor complexes. techniques have recently been developed using optical tweezers to directly measure the packaging of single dna molecules into single procapsids in real time and the forces generated by the molecular motor. three different viruses, phages phi29, lambda, and t4, have been studied, revealing interesting similarities and differences in packaging dynamics. single-molec ... | 2011 | 22440623 |
| the effects of short-term manipulation of thyroid hormone status coinciding with primary wool follicle development on fleece characteristics in merino sheep. | thyroidectomy surgery performed late in gestation results in perturbations in wool follicle development in foetal sheep, showing the importance of thyroid hormones for wool follicle development. the aim of this study was to determine the influence of transient manipulation of thyroid hormone status at a time corresponding with foetal primary wool follicle initiation. pregnant merino ewes (n = 12 per treatment) were treated daily between gestational days 55 and 64 with control (vehicle), exogenou ... | 2011 | 22440286 |
| shelf life study of fresh celery (apium graveolens l.) grown under different nitrogen fertilization treatments. | nitrogen fertilization is useful for obtaining higher growth and quality of productions, and the use of nitrogen fertilization is widespread. to evaluate the influence of nitrogen-rich fertilizers on quality characteristics of celery, shelf life tests of celery grown with 2 levels of nitrogen and 2 different nitrogen fertilizers were performed. the treatments of the celery samples were identified as follows: t1, mineral nitrogen (80 kg ha(-1)); t2, mineral nitrogen (120 kg ha(-1)); t3, organic n ... | 2011 | 22417367 |
| study of the effects of hydrogen cyanide exposure in cassava workers. | hydrogen cyanide is the chemical responsible for tissue hypoxia. chronic exposure to hcn may cause neurological, respiratory, cardiovascular and thyroid defects. onset of symptoms depends on dose and duration of exposure. large scale of cassava processing could be disastrous due to discharge of hydrocyanic acid into the air. cassava processing is the major industrial work in and around salem. hence the present study is taken to assess the effects of hcn exposure in cassava workers. | 2011 | 22412292 |
| [subclinical hypothyroidism and cardiovascular risk factors]. | to determine the prevalence of subclinical hypothyroidism in the general population of an urban health center and describe the clinical characteristics and cardiovascular risk factors in patients with subclinical hypothyroidism. | 2011 | 22411383 |
| extradural en-plaque spinal meningioma with intraneural invasion. | extradural spinal meningiomas are rare. our understanding of purely extradural spinal meningiomas is incomplete because most reports rarely differentiate purely extradural meningiomas from extradural meningiomas with an intradural component. occasionally, reports have described involvement of the adjacent nerve root, but there has never been a description of an extradural meningioma that actually infiltrates the nerve root. | 2011 | 22405399 |
| an atypical case of retropharyngeal abscess with long blind tract treated with ryle's tube drainage. | a 10 year-old iban girl presented with severe odynophagia for 4 days and subcutaneous emphysema. clinically, her neck was tender with crepitus. lateral neck radiograph showed multiple linear radiolucent shadows at retropharyngeal space. flexible nasopharyngolaryngoscope revealed a tunnel behind upper oesophagus with slough and there was pooling of saliva at pyriform sinus. feeding via nasogastric tube was started and empirical treatment for fungal and bacterial infection was commenced. subsequen ... | 2011 | 22390112 |
| [resistance to thyroid hormone and hashimoto's thyroiditis]. | resistance to thyroid hormone (rth) is a rare condition characterized by elevation of thyroid stimulating hormone (tsh) and thyroid hormones (th). its association with hashimoto's thyroiditis was described in 1993 and occurs in 1 of 1.3 million births. | 2011 | 22385766 |
| effect of ramadan fasting on body composition and physical performance in female athletes. | the aim of this study was to determine the effect of ramadan fasting on body composition, calorie intake and physical performance in young female athletes undertaking training sessions during ramadan. | 2011 | 22375235 |
| management of severe class ii division 1 malocclusion: a case report. | to describe the two-phase treatment of a preadolescent boy with a severe skeletal class ii division 1 malocclusion with vertical maxillary excess and spaced upper incisors. | 2011 | 22372276 |
| prevalence of subclinical hypothyroidism among patients with acute myocardial infarction. | introduction. subclinical hypothyroidism (sch) is defined as a serum thyroid-stimulating hormone (tsh) level above the upper limit of normal despite normal levels of serum free thyroxine. there is growing evidence that sch is associated with increased cardiovascular risk. we tried to investigate prevalence of sch in acute myocardial infarction patients. methods and results. we evaluate free t3, free t4, and tsh levels of 604 patients (age 58.4) retrospectively, who have been admitted to the coro ... | 2011 | 22363888 |
| [ileus caused by metastasis of cutaneous malignant melanoma: case report]. | in this case report we describe rare metastatic appearance of cutaneous malignant melanoma ( mm) in small intestine followed by clinical appearance of acute surgical abdomen. a 42-year old women operated in our hospital in april 2009. due to unusual naevus on her right arm. pathologicaly it was mm grossly 1.5 cm, microscopically breslow 11 mm, clark's level iv (t4), number of mitosis 1.4 per mm2, without ulcerations. she was sent to continue treatment at the national referal center for melanoma ... | 2011 | 22359897 |
| on-pump coronary artery bypass graft surgery: biochemical, hormonal and cellular features. | the authors sought to assess biochemical, hormonal and cellular repercussions from use of cardiopulmonary bypass (cpb) in coronary artery bypass graft (cabg) surgery. | 2011 | 22358266 |
| reversal of difluoromethylornithine effects by the administration of putrescine in rats. | to assess the reversal of di-fluoromethyl ornithine (dfmo) effects by administration of putrescine on thyroid glands in rats. | 2011 | 22355995 |
| effects of extrusion and heat treatment on the mechanical properties and biocorrosion behaviors of a mg-nd-zn-zr alloy. | mechanical properties at room temperature and biocorrosion behaviors in simulated body fluid (sbf) at 37 °c of a new type of patented mg-3nd-0.2zn-0.4zr (hereafter, denoted as jdbm) alloy prepared at different extrusion temperatures, as well as heat treatment, were studied. the mechanical properties of this magnesium alloy at room temperature were improved significantly after extrusion and heat treatment compared to an as-cast alloy. the results of mechanical properties show that the yield stren ... | 2011 | 22340687 |
| effects of preoperative ketamine on the endocrine-metabolic and inflammatory response to laparoscopic surgery. | ketamine is hypothesized to reduce perioperative endocrine-metabolic and inflammatory responses in cardiac surgery patients. this randomized, placebo-controlled, double-blind study was performed to determine whether perioperative endocrine-metabolic and inflammatory responses are attenuated by preoperative administration of ketamine to healthy females receiving elective laparoscopic surgery. | 2011 | 22340231 |
| comparison of compensatory sweating and quality of life following thoracic sympathetic block for palmar hyperhidrosis: electrocautery hook versus titanium clip. | video-assisted thoracic sympathetic block is an effective, safe, and minimally invasive method for treatment of primary hyperhidrosis. the purpose of this study was to decide which one of using electrocautery hook and titanium clip is the appropriate procedure for primary palmar hyperhidrosis by assessing the compensatory sweating (cs) and quality of life (qol) of patients after sympathetic block. | 2011 | 22340165 |
| [identification of nucleolar localization signal sequence of tumor metastasis suppressor gene-1]. | to identify the putative specific localization signal sequence of tumor metastasis suppressor gene-1 (tmsg-1) and to explore the mechanism of subcellular localization of tmsg-1 protein. | 2011 | 22336162 |
| [endoscopic surgery and endoscopy-assisted surgery for the malignant transformation of sinonasal inverted papilloma]. | to investigate malignant transformation of sinonasal inverted papilloma (sip) treated by nasal endoscopic and endoscopy-assisted surgery. | 2011 | 22336018 |
| [the clinical application of monitored anesthesia care in percutaneous dilatational tracheostomy]. | to investigate the changes in hemodynamics and depth of anesthesia under monitored anesthesia care (mac) in patients undergoing percutaneous dilatational tracheostomy (pdt). | 2011 | 22332577 |
| breast cancer in women under 40 years of age. | it is widely believed that breast cancer in young women is characterized by a relatively unfavorable prognosis and unusual pathological features. the aim of this study was to investigate clinicopathological and biological characteristics in young patients with breast cancer. | 2011 | 22331714 |
| clinicopathologic significance of gastric adenocarcinoma with neuroendocrine features. | composite neuroendocrine-exocrine carcinomas are malignancies that have two distinct components residing within the same tumor: an adenocarcinomatous portion and a neuroendocrine portion. this is rare in gastric cancers; however, poorly differentiated adenocarcinomas can sometimes reveal evidence of neuroendocrine features (nef) or be 'mixed endocrine and exocrine carcinomas'. this study aimed to review nef in gastric adenocarcinoma and to evaluate its prognostic significance. | 2011 | 22324009 |
| [clinical observation of visual quality after implantation of toric intraocular lens]. | to observe the visual quality after implantation of acrysof toric intraocular lens (iol) in cataract patients. | 2011 | 22321501 |
| spontaneous vacuolar degeneration of the thyroid follicular epithelium in cynomolgus monkeys. | vacuolar degeneration of the thyroid follicular epithelium was observed in two untreated female cynomolgus monkeys assigned to control groups. in light microscopy, large vacuoles containing a homogenous substance occupied the basal region of the epithelium, and the nuclei had shifted toward the apical region. the vacuoles showed negative reactions to pas and thyroglobulin. electron microscopic observation revealed dilatation of the rough endoplasmic reticulum corresponding to the vacuoles. the p ... | 2011 | 22319235 |
| concomitant radiotherapy and chemotherapy for high-risk nonmelanoma skin carcinomas of the head and neck. | background. to report on the use and feasibility of a multimodality approach using concomitant radiotherapy and chemotherapy in patients with high-risk nonmelanoma skin carcinoma (nmsc) of the head and neck. methods. records of patients with nmsc of the head and neck who received concomitant crt at the university of north carolina between 2001 and 2007 were reviewed. results. fifteen identified patients had at least one of the following high-risk factors: t4 disease (93%), unresectability (60%), ... | 2011 | 22312508 |
| central hypothyroidism following chemotherapy for acute lymphoblastic leukemia. | it has been suggested that chemotherapy per se might impair the hypothalamus-pituitary-thyroid axis of childhood cancer survivors. | 2011 | 22308840 |
| neurodevelopment of preterm infants born at 28 to 36 weeks of gestational age: the role of hypothyroxinemia and long-term outcome at 4 years. | hypothyroxinemia in premature neonates may affect long-term neurodevelopment. | 2011 | 22308839 |
| normal thyroid function in young adults who were born very preterm. | there is some evidence for elevated thyrotropin (tsh) levels in children born preterm, but follow-up studies into adulthood are lacking. we tested whether thyroid function in young adults born at a gestational age < 32 weeks, with either an appropriate (appropriate for gestational age, aga) or low birth weight for gestational age (small for gestational age, sga), differed from that in age-matched controls. we made our measurements when the study participants reached 21 years of age. serum concen ... | 2011 | 22308837 |
| [establishment of gynecological asthenia cold syndrome model]. | to establish the model of gynecological asthenia cold syndrome by simulating the etiology of gynecological asthenia cold syndrome depending on 'pathogenic cold impairing yang" in chinese medicine theory. | 2011 | 22303717 |
| [effect of shenfu injection on the erythrocyte immune function of patients undergoing cardiopulmonary bypass]. | to observe the effect of shenfu injection (sfi) on erythrocyte immunity function of patients undergoing cardiopulmonary bypass (cpb). | 2011 | 22303706 |
| patterns of differentiated thyroid cancer in baluchistan province of pakistan: some initial observations. | the incidence of thyroid cancer is increasing in several countries. the main objective of this retrospective study was to find and describe province-specific estimates of incidence in males and females by age groups for differentiated thyroid cancer (dtc). this study reports on 87 cases of dtc from baluchistan province of pakistan treated with post operative radioiodine at the center for nuclear medicine and radiotherapy (cenar) quetta from january 2003 to december 2009. the patient data has bee ... | 2011 | 22299551 |
| effect of anesthesia on the changes in the hormones levels during and after transvesical prostatectomy. | hypovolemia and pain are direct stimulators of hormonal response to trauma. thus, neuroendocrine, metabolic and inflammatory aspects of the injury are part of an overall "stress response". in particular, it manifests in patients undergoing surgical intervention. these reactions can occur with trauma, burns, severe infections and physical exertion. metabolic and neuroendocrine response to surgical intervention depends on several factors, such as severity and duration of the surgical trauma, patie ... | 2011 | 22299297 |
| nestin expression associates with poor prognosis and triple negative phenotype in locally advanced (t4) breast cancer. | nestin, an intermediate filament protein, has traditionally been noted for its importance as a neural stem cell marker. however, in recent years, expression of nestin has shown to be associated with general proliferation of progenitor cell populations within neoplasms. there is no reported study addressing nestin expression in t4 breast cancer patients. thus, the aim of the present study was to investigate, through immunohistochemistry, the expression and distribution of nestin in t4 breast canc ... | 2011 | 22297445 |
| [clinical observation of injection of dexmedetomidine in anaesthesia for esophageal cancer operation]. | to investigate the effects of administration of dexmedetomidine in anaesthesia for esophageal cancer operation. | 2011 | 22295535 |
| the content of cadmium, cobalt and nickel in laryngeal carcinoma. | the aim of the study was to determine the content of cadmium (cd), cobalt (co) and nickel (ni) in the samples from laryngeal carcinoma in comparison with the level of these elements in the samples of healthy mucous membrane from the same larynx. | 2011 | 22295038 |
| clinical and pathological response rates of docetaxel-based neoadjuvant chemotherapy in locally advanced breast cancer and comparison with anthracycline-based chemotherapies: eight-year experience from single centre. | the administration of neoadjuvant chemotherapy (nact) prior to local therapy is advantageous for women with locally advanced breast cancer (labc), since it can render inoperable tumors resectable and can increase rates of breast conservative surgeries. | 2011 | 22293253 |
| [comparison of the maternal and neonatal effects of combined spinal-epidural block and spinal block for cesarean section]. | combined spinal-epidural block (cseb) has gained increasing interest as it combines the reliability of a spinal block (sb) and the flexibility of an epidural block in cesarean section. we investigated the maternal and fetal effect of cseb against sb in cesarean operation. | 2011 | 22290681 |