Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| Swallowing function after transoral laser microsurgery (TLM) ± adjuvant therapy for advanced-stage oropharyngeal cancer. | To perform a longitudinal description of swallowing function following transoral laser microsurgery (TLM) ± adjuvant therapy for advanced-stage oropharyngeal cancer (OPC) and identify prognostic factors associated with swallowing performance. | 2011 | 21882203 |
| Multi-Institutional Analysis of Robotic Radical Cystectomy for Bladder Cancer: Perioperative Outcomes and Complications in 227 Patients. | Abstract Purpose: Recently, some surgeons have begun to describe single-institution case series with less invasive surgical approaches to bladder cancer such as laparoscopic or robotic-assisted techniques. We report on a multi-institutional, multi-surgeon experience with robotic radical cystectomy with regard to operative and pathologic outcomes and complications to evaluate the feasibility and reproducibility of this technique in a large cohort of patients. Subjects and Methods: Two hundred ... | 2011 | 22142028 |
| Structure-function analysis of HsiF, a gp25-like component of the type VI secretion system, in Pseudomonas aeruginosa. | Bacterial pathogens use a range of protein secretion systems to colonize their host. One recent addition to this arsenal is the type VI secretion system (T6SS), which is found in many Gram-negative bacteria. The T6SS involves 12-15 components, including a ClpV-like AAA(+) ATPase. Moreover, the VgrG and Hcp components have been proposed to form a puncturing device, based on structural similarity to the tail spike components gp5/gp27 and the tail tube component gp19 of the T4 bacteriophage, respec ... | 2011 | 21873404 |
| Gastrectomy as a secondary surgery for stage IV gastric cancer patients who underwent S-1-based chemotherapy: a multi-institute retrospective study. | BACKGROUND: Current advances in chemotherapy provide opportunities for stage IV gastric cancer patients with distant metastasis to undergo potentially curable resection. There are, however, few data on gastrectomy as a secondary surgery aimed at rendering such patients cancer-free. METHODS: We investigated stage IV gastric cancer patients who underwent surgery with curative intent after S-1-based chemotherapy bet ... | 2011 | 22033890 |
| multiple synchronous primary tumours in a single lobe. | we present the case of a 70-year-old man with three synchronous histologically different primary tumours in the same lobe. he initially presented with an intermittent productive cough, dyspnoea and non-specific abdominal pains. radiological investigation revealed three areas of high-intensity fludeoxyglucose uptake of varying size within the right upper lobe. he underwent thoracoscopic right upper lobectomy. histological analysis confirmed the three lesions to be undifferentiated squamous cell c ... | 2011 | 22159234 |
| Sequential evaluations of trace elements in patients receiving parenteral nutrition. | To evaluate alterations of serum trace element (TE) levels in critically ill patients receiving parenteral nutrition (PN) including the recommended doses of TEs. | 2011 | 21940305 |
| vash is a transcriptional regulator of the type vi secretion system functional in endemic and pandemic vibrio cholerae. | the gram-negative bacterium vibrio cholerae is the etiological agent of cholera, a disease characterized by the release of high volumes of watery diarrhea. many medically important proteobacteria, including v. cholerae, carry one or multiple copies of the gene cluster that encodes the bacterial type vi secretion system (t6ss) to confer virulence or interspecies competitiveness. structural similarity and sequence homology between components of the t6ss and the cell-puncturing device of t4 bacteri ... | 2011 | 21949076 |
| Effectiveness and pitfalls of elective neck dissection in N0 laryngeal cancer. | The aim of the study was to evaluate the efficacy and potential pitfalls of selective neck dissection of levels II-IV in controlling occult neck disease in clinically negative neck (cN0) of patients with laryngeal squamous cell carcinoma. Charts of 96 consecutive cN0 laryngeal cancer patients undergoing 122 neck dissections at the University of Florence from January 2000 to December 2004 were reviewed. N0 neck was defined with contrast enhanced computed tomography scan. Occult neck disease rate ... | 2011 | 22058599 |
| Neoadjuvant Chemotherapy in 29 Patients with Locally Advanced Follicular or Hürthle Cell Thyroid Carcinoma: A Phase 2 Study. | Background: It is believed that chemotherapy (ChT) is ineffective in follicular thyroid carcinoma (FTC) and Hürthle cell thyroid carcinoma (HCTC). The aim of our retrospective study was to find out whether neodjuvant ChT before thyroid surgery had any effect on the size of primary tumor in patients with FTC or HCTC. Methods: The study included 29 patients (20 women, 9 men; mean age: 60.8 years) with FTC or HCTC who had T3 or T4 tumor and were treated with neoadjuvant ChT from 1979 to 2004. A m ... | 2011 | 22175241 |
| Geofold: Topology-based protein unfolding pathways capture the effects of engineered disulfides on kinetic stability. | Protein unfolding is modeled as an ensemble of pathways, where each step in each pathway is the addition of one topologically possible conformational degree of freedom. Starting with a known protein structure, GeoFold hierarchically partitions (cuts) the native structure into substructures using revolute joints and translations. The energy of each cut and its activation barrier are calculated using buried solvent accessible surface area, side chain entropy, hydrogen bonding, buried cavities, and ... | 2011 | 22189917 |
| Thrombin generation in severe sepsis. | INTRODUCTION: Hemostasis and inflammation are two tightly interrelated systems in the host's response to infection. Thrombin generation in sepsis plays a crucial role in enhancing and modulation of inflammation. The present study aimed to investigate the course of thrombin generation in patients with severe sepsis, and its correlation with outcome. MATERIALS AND METHODS: Thrombin generation was measured in platelet-poor plasma from 32 healthy controls and 75 patients with severe sepsis using the ... | 2011 | 21872299 |
| Viral Infections in Septic Shock (VISS-Trial)-Crosslinks Between Inflammation and Immunosuppression. | BACKGROUND: Recent investigations provided evidence that herpes simplex virus (HSV-1) and cytomegalovirus (CMV) are reactivated in critically ill individuals. However, at this time, it remains unclear whether these viral infections are of real pathogenetic relevance or represent innocent bystanders. MATERIALS AND METHODS: In total, 60 patients with septic shock were enrolled. Blood samples and tracheal secretion were collected at the time of sepsis diagnosis (T0) as well as 7 d (T1), 14 d (T2), ... | 2011 | 22172138 |
| The incidence of thyroid function abnormalities and natural course of subclinical thyroid disorders, Tehran, I. R. Iran. | Back ground: Despite the high prevalence of thyroid dysfunction, the epidemiology and natural course of these disorders have not yet been identified. Aim: the present survey was conducted to determine the incidence of thyroid dysfunction and natural course of subclinical thyroid disorders in an urban community of Tehran, I. R. Iran. Subjects & Methods: Serum TSH and thyroperoxidase antibody (TPOAb) were measured at baseline and after 6.7 years from a sample of 1999 randomly selected subjects ... | 2011 | 21971483 |
| spinal intradural, extramedullary anaplastic ependymoma with an extradural component: case report and review of the literature. | there have been 18 reported cases of primary spinal intradural, extramedullary ependymomas reported in the literature. one of the 18 cases had an extradural component and was benign. our case is the second spinal intradural, extramedullary ependymoma with an extradural component and the first with its initial presentation as an anaplastic ependymoma. | 2011 | 21918734 |
| treatment with levothyroxine in pregnant rats with subclinical hypothyroidism improves cell migration in the developing brain of the progeny. | aim: this study aims to investigate whether maternal subclinical hypothyroidism (sch) influences the developing brain, and the effect of treatment with levothyroxine in early maternal sch on the progeny's developing brain. material and methods: 75 thyroidectomized female wistar rats were divided randomly into groups of hypothyroidism (ch), sch, sch treated with levothyroxine from embryonic day 10 (e10), e13 and e17 till post-natal day 21. there were 15 sham operated controls. results: pups from ... | 2011 | 22024639 |
| decreased levels of alternative co-stimulatory receptors ox40 and 4-1bb characterise t cells from head and neck cancer patients. | background and aim: head and neck cancers (hnc) are aggressive tumours. tumour-specific t cells are frequently identified in patients with cancer, although they fail to control tumour progression. a family of proteins called co-stimulatory receptors regulate the function of t cells and may account for t cell dysfunction in cancer. our aim was to characterise co-stimulatory receptors on t cells in hnc patients to identify novel targets for immunotherapy. methods: peripheral blood mononuclear cell ... | 2011 | 22204816 |
| expression analysis elucidates the roles of maml1 and twist1 in esophageal squamous cell carcinoma aggressiveness and metastasis. | background: epithelial-mesenchymal transition has recently attracted great attention in studying the malignant progression of cells through a converging pathway of oncogenesis and metastasis. twist1 and mastermind-like 1 (maml1) are major regulators of emt through different pathways. the aim of this study was to investigate the clinicopathological relevance of the expression of maml-1 and twist1 genes in esophageal squamous cell carcinoma (escc). ... | 2011 | 22006371 |
| thyroid autoimmunity in children with coeliac disease: a prospective survey. | thyroid autoimmunity (ta) is often associated with coeliac disease (cd). | 2011 | 21862521 |
| Quality of life and patient satisfaction after video-assisted thoracic sympathicolysis for essential hyperhidrosis: a follow-up of 138 patients. | Abstract Objectives: Essential hyperhidrosis (EH) is defined as excessive functioning of the sudomotor sweat system. Definitive treatment of choice is video-assisted thoracoscopic sympathetic interruption. Success rates are high, but compensatory hyperhidrosis (CH) remains a troublesome side effect. The aim of this study was to document patient satisfaction and side effects at least 6 months after thoracoscopic sympathicolysis. Methods: Between 2001 and 2005, 246 patients underwent bilateral ... | 2011 | 22011277 |
| Predictors of survival and recurrence after temporal bone resection for cancer. | BACKGROUND: The purpose of this study was to identify factors predictive of outcome in patients undergoing temporal bone resection (TBR) for head and neck cancer. METHODS: This was a retrospective study of 72 patients undergoing TBR. Factors associated with survival and recurrence were identified on multivariable regression. RESULTS: Most tumors were epithelial (81%), commonly (69%) involving critical structures. Cervical metastases were uncommon (6%). Squamous cell carcinoma (SCC) of the extern ... | 2011 | 21953902 |
| Guideline for prophylactic feeding tube insertion in patients undergoing resection of head and neck cancers. | BACKGROUND: Supplementary nutrition is an important aspect of the multidisciplinary management of head and neck cancer patients. In our unit, method of feeding is based on an arbitrary predicted duration of overall treatment (<30 days indicates NG feeding, >30 days prophylactic PEG tube insertion is appropriate). This paper provides a guideline to assist in choosing the feeding method early on to avoid the need for later PEG insertion in those who were initially fed orally or via NG tube. PATIEN ... | 2011 | 22137826 |
| The Prevalence of Undetected Vertebral Fracture in Patients with Back Pain by Dual-Energy X-ray Absorptiometry (DXA) of the Lateral Thoracic and Lumbar Spine. | This is a prospective study. | 2011 | 21892385 |
| effect of different propranolol doses on skeletal structural and mechanic efficiency in an animal model of growth retardation. | objective: to assess in a growth retardation (gr) model the impact of different propranolol (p) doses on anthropomorphometric and biomechanical variables of the appendicular skeleton. materials and methods: twenty-one day-old male wistar rats were divided into the following groups: control (c), c+p3.5 (cp3.5); c+p7 (cp7); c+p10.5 (cp10.5); c+p14 (cp14); ed, ed+p3.5 (edp3.5); ed+p7 (edp7); ed+p10.5 (edp10.5), and ed+p14 (edp14). control animals with/without p were fed a rodent diet ad libitum. gr ... | 2011 | 22094148 |
| biochemical characterization of a structure-specific resolving enzyme from sulfolobus islandicus rod-shaped virus 2. | sulfolobus islandicus rod shaped virus 2 (sirv2) infects the archaeon sulfolobus islandicus at extreme temperature (70°c-80°c) and acidity (ph 3). sirv2 encodes a holliday junction resolving enzyme (sirv2 hjr) that has been proposed as a key enzyme in sirv2 genome replication. the molecular mechanism for sirv2 hjr four-way junction cleavage bias, minimal requirements for four-way junction cleavage, and substrate specificity were determined. sirv2 hjr cleaves four-way dna junctions with a prefere ... | 2011 | 21858199 |
| Preoperative Radiation Therapy for Upper Rectal CancerT3,T4/Nx: Selectivity Essential. | This review explores the current available literature regarding the role of neoadjuvant therapy for upper locally advanced rectal cancers (=10cm-15cm). Although there is a paucity of data evaluating the outcomes of preoperative chemoradiation for upper rectal cancers the authors suggest that T3N0 tumors will not likely benefit from radiation and that treatment of T4N0 should be individualized. | 2011 | 22154165 |
| upregulation of β2-microglobulin expression in progressive human oral squamous cell carcinoma. | the aim of the present study was to investigate β2-microglobulin (β2-m) expression in normal oral mucosa and progressive oral squamous cell carcinoma (oscc) and to assess the clinical significance of β2-microglobulin expression. the study included 10 cases of normal oral mucosa epithelium specimens, 55 cases of primary oscc specimens, and 25 cases of oscc metastasis specimens. immunohistochemistry was used to determine β2-m expression, ... | 2011 | 22211248 |
| patients with adolescent idiopathic scoliosis of lenke type-1 curve exhibit specific pedicle width pattern. | study aim was to find out if patients with lenke type 1 curve exhibit smaller pedicles and specific pedicle width pattern compared with individuals with no scoliosis. | 2011 | 22045200 |
| timing of plasmid cytokine (il-2/ig) administration affects hiv-1 vaccine immunogenicity in hiv-seronegative subjects. | to investigate the potential immunostimulatory effect of interleukin (il) 2 as a human immunodeficiency virus type 1 (hiv-1) vaccine adjuvant, we conducted a study of a plasmid coding for a fusion protein of il-2 and immunoglobulin (il-2/ig). | 2011 | 21940420 |
| A fatal case of Pneumocystis jirovecii pneumonia in a breast cancer patient receiving weekly paclitaxel and trastuzumab. | Pneumocystis jirovecii (formerly carinii) pneumonia (PJP) is an opportunistic infection well-recognized in patients with profound T cell immunodeficiency. It is much less common in patients with solid tumors unless they have other major predisposing factors such as prolonged treatment with corticosteroids or T4 lymphocyte counts of less than 200 cells/mm(3). We present a previously unreported case of fatal PJP in a breast cancer patient with bone metastases who was receiving a first-line treatme ... | 2011 | 21911478 |
| clinicopathological and prognostic role of cyclin d1 in esophageal squamous cell carcinoma: a meta-analysis. | cyclin d1 is one of the most commonly over-expressed oncogenes; however, its role in esophageal squamous cell carcinoma (escc) remains controversial. we conducted a meta-analysis of 20 studies, comprising 2,041 patients to clarify this issue. in all studies, paraffin-embedded surgical specimens were collected and the status of cyclin d1 was determined by immunohistochemistry (ihc). the combined odds ratios (ors) for cyclin d1 expression were 0.74 (95% confidence interval [ci]: 0.58-0.93) for wel ... | 2011 | 22098104 |
| identification of chromosomal breakpoints of cancer-specific translocations by rolling circle amplification and long-distance inverse pcr. | we describe the use of rolling circle amplification and long-distance inverse polymerase chain reaction (ld-pcr) to identify chromosomal breakpoints and fusion genes in cancer cells carrying acquired translocations. this approach produced enough template for 100 inverse pcr reaction from as little as 20 ng of patient dna, consequently enabling the use of up to 500 times less patient dna compared to standard inverse pcr. the method is based on identifying restriction sites in a putative breakpoin ... | 2011 | 21962896 |
| the efficacy and safety of neoadjuvant chemotherapy +/- letrozole in postmenopausal women with locally advanced breast cancer: a randomized phase iii clinical trial. | this two-arm randomized clinical study aimed to evaluate the efficacy and safety of neoadjuvant concurrent chemotherapy and letrozole in postmenopausal women with locally advanced breast carcinoma. one hundred and one postmenopausal women aged 50-83 years with pathologically proven locally advanced (clinical stage t3, t4 and/or n2, n3) breast cancer were randomly assigned to receive neoadjuvant chemotherapy alone (control arm, n = 51) or neoadjuvant chemotherapy concurrent with letrozole 2.5 mg ... | 2011 | 22002564 |
| Prognostic value of preoperative radiological staging assessed by computed tomography in patients with nonmetastatic colon cancer. | Purpose: This study evaluated the prognostic value of preoperative locoregional staging in patients with colon cancer and who underwent curative resection. METHODS: A total of 536 consecutive patients who underwent curative resection for colon cancer from February 1999 to November 2007 were prospectively enrolled. The clinicopathological variables, including the radiological staging using computed tomography, were analyzed for the prognostic significance. RESULTS: The 5-year overall survival r ... | 2011 | 21948813 |
| grb7 is required for triple-negative breast cancer cell invasion and survival. | triple-negative breast cancer (tnbc) is a heterogeneous disease that is usually associated with poor prognosis, and frequently associated with the basal-like breast cancer gene expression profile. there are no targeted therapeutic modalities for this disease, and no useful biomarkers. high grb7 rna expression levels are associated with an elevated risk of recurrence in patients with operable tnbc treated with standard adjuvant anthracycline and taxane therapy. to determine whether grb7 is involv ... | 2011 | 22005836 |
| positive lymphoscintigraphy (ils) and negative computed tomography for metastatic penile cancer. | penile carcinoma usually occurs in older than 40 years men with an incidence in western communities of 0.5 to 1.6 per 100,000 men per year while in developing countries the rate is much higher in men. extensive lymph node dissection of lymphatic inguinal metastases evident by inguinal lymphoscintigraphy (ils) induces improved overall survival. a 75 years old male with penile squamous cell carcinoma stage pt2n0m0 of less than 2cm diameter, with tumor invasion of the penis corpora underwent parti ... | 2011 | 22087456 |
| a randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-fluorouracil versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (jcog9907). | background: patients with esophageal carcinoma receiving postoperative chemotherapy showed superior disease-free survival than those receiving surgery alone in a japan clinical oncology group trial (jcog9204). the purpose of this study was to evaluate optimal perioperative timing-that is, before or after surgery-for providing chemotherapy in patients with locally advanced esophageal squamous cell carcinoma. methods: eligible patients with clinical stage ii or iii, excluding t4, squamous cell car ... | 2011 | 21879261 |
| propylthiouracil-induced interstitial pneumonia in a caucasian women with amiodarone induced thyrotoxicosis. | background. propylthiouracil (ptu) therapy is associated with a variety of adverse reactions, among the most rare being interstitial pneumonia. to date, this has been reported in four asian patients with autoimmune hyperthyroidism. here we describe a caucasian woman who developed a bronchiolitis obliterans organizing pneumonia (boop)-like interstitial pneumonia after ptu administration for amiodarone-induced thyrotoxicosis. patient findings. the patient was a 68 year old women who had been tre ... | 2011 | 22150593 |
| in vitro and in vivo antiparasitic activity of azadirachtin against argulus spp. in carassius auratus (linn. 1758). | argulus is one of the most common and predominant ectoparasites which cause serious parasitic disease and is a potent carrier of viruses and bacteria in the ornamental fish industry. in recent years, organic (herbs)-based medicines are widely used to cure the disease, and neem (sarbaroganibarini) medicine is very popular and effective throughout the world. the present study was conducted to find the effects of azadirachtin against argulus spp. on carassius auratus under in vitro and in vivo cond ... | 2011 | 22042504 |
| laparoscopic radical prostatectomy: oncological and functional outcomes of 559 cases in siriraj hospital, thailand. | to evaluate the results of oncological and functional outcomes of laparoscopic radical prostatectomy (lrp) during the first five years experience in siriraj hospital. | 2011 | 21863675 |
| free thyroxine, free triiodothyronine and thyroid-stimulating hormone before and after hemodialysis in saudi patients with end-stage renal disease: is there any difference? | patients on regular hemodialysis (hd) suffer from a chronic illness that is believed not to involve the thyroid gland. however, they may have low levels of serum thyroxine (t4) and tri-iodothyronine (t3). it was found earlier that serum total t3 and free t4 concentrations were significantly higher immediately after a hd session than before. in this single-center prospective study, we evaluated the difference between free t3 (ft3), free t4 (ft4) and thyroid-stimulating hormone (tsh) levels before ... | 2011 | 21912019 |
| locally advanced prostate cancer: a population-based study of treatment patterns. | study type - therapy (practice patterns) level of evidence 2b what's known on the subject? and what does the study add? the treatment of locally advanced prostate cancer varies widely even though there is level one evidence supporting the use of multimodality therapy as compared with monotherapy. this study defines treatment patterns of locally advanced prostate cancer within the united states and identifies predicators of who receives multimodality therapy rather than monotherapy. objective: • ... | 2011 | 22085255 |
| acanthamoeba belonging to t3, t4, and t11: genotypes isolated from air-conditioning units in santiago, chile. | free-living amoebae (fla) of the genus acanthamoeba are widely distributed in the environment, in the air, soil, and water, and have also been isolated from air-conditioning units. the objective of this work was to investigate the presence of this genus of fla in the air-conditioning equipment at the institute of public health of chile in santiago, chile. water and air samples were collected from air-conditioning systems and were checked for the presence of acanthamoeba spp. positive samples wer ... | 2011 | 22092528 |
| [treatment strategy for stage ii/iii( non-t4)advanced esophageal cancer in high-risk patients]. | we evaluated treatment strategies for stage ii/iii( non-t4) advanced esophageal cancer in high-risk( hr) patients and analyzed the relationship between e-pass scoring system( e-pass) and hr patients retrospectively. the subjects were 85 patients who received the treatment for stage ii/iii( non-t4) advanced esophageal cancer between 2006 and 2010 in our institute. the patients were divided into the hr and non high-risk( nhr) group. in this study, hr patients were defined as satisfying at least on ... | 2011 | 22202389 |
| a single-step competitive binding assay for mapping of single dna molecules. | optical mapping of genomic dna is of relevance for a plethora of applications such as scaffolding for sequencing and detection of structural variations as well as identification of pathogens like bacteria and viruses. for future clinical applications it is desirable to have a fast and robust mapping method based on as few steps as possible. we here demonstrate a single-step method to obtain a dna barcode that is directly visualized using nanofluidic devices and fluorescence microscopy. using a m ... | 2011 | 22166208 |
| total laryngectomy for laryngeal cancer in a nigerian tertiary health center: prognosis and outcome. | advanced laryngeal cancers presenting with upper airway obstruction are a common scenario in sub-saharan africa, requiring operative intervention as a priority. | 2011 | 22022650 |
| age, place of living and education influences the pregnancy universal thyroid function screening program attendance - questionnaire study. | the aim of this study was to assess attendance at the universal screening programme for thyroid function in pregnancy and attempt to evaluate the influence of age, number of past pregnancies, level of education, and place of residence on the attendance. the study was performed by means of a questionnaire. | 2011 | 22069102 |
| snd2, a nac transcription factor gene, regulates genes involved in secondary cell wall development in arabidopsis fibres and increases fibre cell area in eucalyptus. | abstract: background: nac domain transcription factors initiate secondary cell wall biosynthesis in arabidopsis fibres and vessels by activating numerous transcriptional regulators and biosynthetic genes. nac family member snd2 is an indirect target of a principal regulator of fibre secondary cell wall formation, snd1. a previous study showed that overexpression of snd2 produced a fibre cell-specific increase in secondary cell wall thickness in arabidopsis stems, and that the protein was able t ... | 2011 | 22133261 |
| spinal pilocytic astrocytoma in an elderly patient. | objective: astrocytomas are the most common intramedullary spinal cord tumor (imsct) in pediatric and adolescent patients and the incidence decreases with age. there are very few cases of spinal pilocytic astrocytomas (who grade 1) reported after the fourth decade. we report the oldest known case of a pathologically confirmed spinal pilocytic astrocytoma. methods: a 78-year-old female presented with 12 months of bilateral lower extremity numbness. magnetic resonance imaging (mri) revealed cord e ... | 2011 | 22120566 |
| genotyping of acanthamoeba isolated from water in recreational areas of tehran, iran. | a comprehensive survey assessing the presence of acanthamoeba was conducted on 50 samples from water sources in parks and public squares from 22 municipal districts of tehran, iran. the prevalence and genotypes of acanthamoeba were determined by pcr and the pcr fragments of ribosomal rna genes sequenced. sixteen (32%) samples were positive for acanthamoeba spp. sequence analysis revealed that the positive isolates belonged to the t4 and t5 genotypes. fourteen isolates (87.5%) were t4, and two (1 ... | 2011 | 21976207 |
| Plasmatic vasopressin in patients undergoing conventional infra-renal abdominal aorta aneurysm repair. | To evaluate plasmatic arginine vasopressin (AVP) levels in patients undergoing scheduled conventional abdominal aortic aneurysm (AAA) repair. | 2011 | 22086577 |
| Restriction enzyme-free construction of random gene mutagenesis libraries in Escherichia coli. | Directed evolution relies on both random and site-directed mutagenesis of individual genes and regulatory elements to create variants with altered activity profiles for engineering applications. Central to these experiments is the construction of large libraries of related variants. However, a number of technical hurdles continue to limit routine construction of random mutagenesis libraries in Escherichia coli, in particular, inefficiencies during digestion and ligation steps. Here, we report a ... | 2011 | 22155067 |
| adenine recognition is a key checkpoint in the energy release mechanism of phage t4 dna packaging motor. | atp is the source of energy for numerous biochemical reactions in all organisms. tailed bacteriophages use atp to drive powerful packaging machines that translocate viral dna into a procapsid and compact it to near-crystalline density. here we report that a complex network of interactions dictates adenine recognition and atp hydrolysis in the pentameric phage t4 large "terminase" (gp17) motor. the network includes residues that form hydrogen bonds at the edges of the adenine ring (q138 and q143) ... | 2011 | 22100308 |
| significant association between thyroid hormones and erythrocyte indices in euthyroid subjects. | objective hypothyroidism and hyperthyroidism are each associated with anaemia, but relationships between thyroid function and erythrocyte indices in euthyroid subjects have not been examined. the aim of this study was to examine these relationships in a community-based cohort. design, subjects and measurements linear regression models with free t4, free t3 and tsh as predictors of erythrocyte indices and serum iron parameters were fitted to data from a cohort of 1179 participants in the 1994 b ... | 2011 | 21913954 |
| Are thyroid hormone concentrations at birth associated with subsequent autism diagnosis? | Thyroid hormones substantially influence central nervous system development during gestation. We hypothesized that perturbations of early thyroid profiles may contribute to the development of autism spectrum disorders (ASD). Thyroid pathways could provide a mechanism by which environmental factors that affect the thyroid system may impact autism occurrence or phenotypic expression. We investigated whether thyroxine (T4) levels at birth are associated with subsequent ASD, using two existing Calif ... | 2011 | 21882364 |
| [Thyreopathy in primary care]. | Thyroid gland disorders, as the core of all endocrinopathies, affect 5-7% of the population of the Czech Republic, with women being affected 6-8 times more often than men. Clinically, thyreopathies are divided into hormonal production disorders and morphology disorders. Thyroid hormones fT3, fT4 and TSH serum levels determine the diagnosis of a thyroid gland disorder. Primary hypothyreosis is characterized by reduced fT4 and increased TSH. Low T3 syndrome is a protective reaction of the organism ... | 2011 | 21957775 |
| [Patient-controlled epidural analgesia combined with patient-controlled intravenous analgesia for postoperative analgesia after miles' operation for rectal cancer]. | A 69-year-old woman (156 cm, 53 kg) underwent a Miles' operation, total hysterectomy, resection of vagina, and thigh flap to vulva for rectal cancer. Before general anesthesia, an epidural catheter was inserted at T11-12 interspace, and 1.5% mepivacaine 7ml was administered. Sensory block level spread from T4 to L1. Anesthesia was induced with propofol and maintained with sevoflurane in air oxygen mixture. Operation was performed uneventfully. After the operation, postoperative analgesia was ach ... | 2011 | 21861422 |
| [Rectal cancer: The radiation basis of radiotherapy, target volume]. | Since the implementation of preoperative chemoradiotherapy and mesorectal excision, the 5-year rates of locoregional failures in T3-T4 N0-N1 M0 rectal cancer fell from 25-30% thirty years ago to 5-8% nowadays. A critical analysis of the locoregional failures sites and mechanisms, as well as the identification of nodal extension, helps the radiation oncologist to optimize the radiotherapy target definition. The upper limit of the clinical target volume is usually set at the top of the third sacra ... | 2011 | 21890393 |
| modulation of the processive abasic site lyase activity of a pyrimidine dimer glycosylase. | the repair of cis-syn cyclobutane pyrimidine dimers (cpds) can be initiated via the base excision repair (ber) pathway, utilizing pyrimidine dimer-specific dna glycosylase/lyase enzymes (pdgs). however, prior to incision at lesion sites, these enzymes bind to non-damaged dnas through charge-charge interactions. following initial binding to dna containing multiple lesions, the enzyme incises at most of these sites prior to dissociation. if a subset of these lesions are in close proximity, cluster ... | 2011 | 21889915 |
| two pathways for rnase e action in escherichia coli in vivo and bypass of its essentiality in mutants defective for rho-dependent transcription termination. | the endonuclease rnase e of escherichia coli is essential for viability, but deletion of its c-terminal half (cth) is not lethal. rnase e preferentially acts on 5'-monophosphorylated rna whose generation from primary transcripts is catalysed by rpph, but δrpph strains are viable. here we show that the rnase e-δcth δrpph combination is lethal, and that the lethality is suppressed by rho or nusg mutations impairing rho-dependent transcription termination. lethality was correlated with defects in b ... | 2011 | 22026368 |
| quality of life in breast cancer survivors: 2 years post self-management intervention. | introduction: today, cancer survivors have an added new role to self manage living with the medical, emotional and role tasks that can affect their quality of life (qol). the purpose of the study was to evaluate the qol of women two years after participating in a self-management intervention program. method: the clinical trial was conducted at university malaya medical centre between 2006 and 2008. the experimental group underwent a 4-week self management program, and the control group underwent ... | 2011 | 22126488 |
| medical image analysis: computer-aided diagnosis of gastric cancer invasion on endoscopic images. | background: the aim of this study was to investigate the efficacy of diagnosing depth of wall invasion of gastric cancer on endoscopic images using computer-aided pattern recognition. methods: the back propagation algorithm was used for computer training. data of 344 patients who underwent gastrectomy or endoscopic tumor resection between 2001 and 2010 and their 902 endoscopic images were collected. the images we ... | 2011 | 22083334 |
| regulation of adiponectin gene expression in adipose tissue by thyroid hormones. | available experimental data suggest that adiponectin and thyroid hormones have biological interaction in vivo. however, the effects of thyroid hormones on adipose adiponectin gene expression in thyroid dysfunction are unclear. we induced hyper- (hyper) and hypothyroidism (hypo) by daily administration of a 12 mg/l of levothyroxine and 250 mg/l of methimazole in drinking water of rats, respectively, for 42 days. the white adipose tissues and serum sample were taken on days 15, 28, 42 and also 2 w ... | 2011 | 22127636 |
| [pharmacological effects of oleum cinnamomi and water extract of cortex cinnamomi in rats with yang-deficiency cold syndrome and the mathematical analysis]. | to compare the effects of oleum cinnamomi and water extract of cortex cinnamomi in rats with yang-deficiency cold syndrome based on mathematical analysis. | 2011 | 21906523 |
| positive correlation between type 1 and 2 iodothyronine deiodinases activities in human goiters. | type 1 (d1) and 2 (d2) iodothyronine deiodinases are selenocysteine-containing enzymes that catalyze the deiodination of t4 to t3 in the thyroid and in peripheral tissues. despite their importance to the plasma t3 pool in human beings, there are few studies about their behavior in human thyroids. in order to better understand iodothyronine deiodinase regulation in the thyroid gland, we studied thyroid tissue samples from follicular adenoma (ad, n = 5), toxic diffuse goiter (tdg, n = 6), nontoxic ... | 2011 | 22207295 |
| differentiated thyroid carcinomas in childhood: clinicopathologic results of 26 patients. | epithelial solid tumors which are rare in childhood are responsible for about 9% of all childhood cancers. however, differentiated thyroid carcinomas (dtcs) are the most common of the endocrine neoplasia (0.5%-3%) in all childhood malignancies. pediatric thyroid cancers have some clinicopathological differences from adult thyroid cancers. this analysis investigates the clinical behavior and pathological characteristics of childhood thyroid cancers, with treatment options and outcomes. a total of ... | 2011 | 22145466 |
| subclinical hypothyroidism and cardiovascular risk: recommendations for treatment. | the definition of subclinical hypothyroidism (sch) is solely biochemical: a serum free t4 level within the reference range in the presence of an elevated serum thyroid-stimulating hormone (tsh) level. while overt hypothyroidism is associated with an increased cardiovascular disease risk, sch, the mildest form of hypothyroidism, may also be associated with an increased cardiovascular disease risk, but to a lesser degree. recent evidence points to a significant trend toward an increase in cardiova ... | 2011 | 21983317 |
| membrane and nuclear permeabilization by polymeric pdna vehicles: efficient method for gene delivery or mechanism of cytotoxicity? | the aim of this study is to compare the cytotoxicity mechanisms of linear pei to two analogous polymers synthesized by our group: a hydroxyl-containing poly(l-tartaramidoamine) (t4) and a version containing an alkyl chain spacer poly(adipamidopentaethylenetetramine) (a4) by studying the cellular responses to polymer transfection. we have also synthesized analogues of t4 with different molecular weights (degrees of polymerization of 6, 12, and 43) to examine the role of molecular weight on the c ... | 2011 | 22175236 |
| effects of adjuvant treatment on cognitive function in women with early breast cancer. | purpose: whether adjuvant therapy impairs cognitive function in women with breast cancer (bc) is unclear. we determined the effects of adjuvant therapy on cognitive function in women with early bc. methods: we consecutively and prospectively enrolled women aged 40-69 years who had a positive radiographic finding from the mammography screening program at stockholm south general hospital. all women completed the headminder web-based neuropsychological battery cognitive stability index (csi) for re ... | 2011 | 21908235 |
| analysis of the seventh edition of american joint committee on colon cancer staging. | purpose: the seventh edition of the american joint committee on cancer (ajcc) staging system has new substages for colon cancer. we used survival data from a single medical center to analyze this new ajcc edition. methods: the colon cancer database of taipei veterans general hospital provided 1,865 patient records covering from 1999 to 2005. survival rates were evaluated using the kaplan-meier method. ... | 2011 | 22146786 |
| factors influencing the outcomes of primary surgery with postoperative radiotherapy for pn2 oropharyneal squamous cell carcinoma. | the purpose of this study was to examine treatment outcomes and define factors that influence survival in patients with pn2 oropharyngeal carcinoma. fifty-five patients underwent primary surgery with postoperative radiotherapy between 1994 and 2009. primary tumor sites were 36 tonsil, 13 base of tongue, 3 soft palate, and three posterior pharyngeal wall. there were 15, 26, 5, and 9 patients with stage t1 to t4 cancers, respectively. the n stage were 5 n2a, 37 n2b, and 13 n2c. the 5-year disease- ... | 2011 | 21924946 |
| estimation of stature from the foot and its segments in a sub-adult female population of north india. | abstract: | 2011 | 22104433 |
| serum tsh level in healthy koreans and the association of tsh with serum lipid concentration and metabolic syndrome. | the proper treatment of subclinical hypothyroidism and the normal range of serum thyroid stimulating hormone (tsh) concentration are intensely debated. however, few reports have investigated tsh concentrations in asian ethnic groups. therefore, the present study was designed to define the tsh reference range in a korean population and to investigate the metabolic significance of tsh concentration. | 2011 | 22205844 |
| diagnostic and prognostic significance of prostate specific antigen and serum interleukin 18 and 10 in patients with locally advanced prostate cancer: a prospective study. | background: prostate cancer is one of the most common cancers afflicting men today. prostate biopsy, an invasive procedure is generally used for diagnoses but attempts are being made to find accurate and precise non- invasive biomarkers. diagnostic accuracy of prostate specific antigen (psa) has been well documented. serum interleukin-18 (il-18) and interleukin-10 (il-10) have shown their diagnostic ability in other cancers but not investigated well in prostate cancer. this study, thus determine ... | 2011 | 22126577 |
| adaptive radiotherapy for head-and-neck cancer: initial clinical outcomes from a prospective trial. | purpose: to present pilot toxicity and survival outcomes for a prospective trial investigating adaptive radiotherapy (art) for oropharyngeal squamous cell carcinoma. methods and materials: a total of 24 patients were enrolled in an institutional review board-approved clinical trial; data for 22 of these patients were analyzed. daily ct-guided setup and deformable image registration permitted serial mapping of clinical target volumes and avoidance structures for art planning. primary site was bas ... | 2011 | 22138459 |
| effects of butachlor on reproduction and hormone levels in adult zebrafish (danio rerio). | butachlor, a chloracetamide herbicide, is widely used in china. in the present study, paired adult male and female zebrafish (danio rerio) were exposed to various concentrations of butachlor (0, 25, 50 and 100μg/l) for 30 days, and the effects on reproduction and endocrine disruption were evaluated using fecundity, condition factor (cf), gonadosomatic index (gsi), liver somatic index (lsi), plasma vitellogenin (vtg), sex steroids and thyroid hormone levels as endpoints. our results showed that t ... | 2011 | 21920721 |
| clinical pathology of greyhounds and other sighthounds. | owing to the development of greyhounds as racing sighthounds, these dogs have acquired unique physiologic adaptations that distinguish them from other breeds. reference intervals for many analytes in retired racing greyhounds (rrgs) differ from those of other breeds; most of the hematologic differences have also been described in other sighthounds. in this review, we provide a survey of the literature on clinical pathology of greyhounds and other sighthounds and results of laboratory testing, in ... | 2011 | 22092909 |
| the c-terminal domain of the adenomatous polyposis coli (apc) protein is involved in thyroid morphogenesis and function. | adenomatous polyposis coli (apc) is a multifunctional protein as well as a tumor suppressor. to determine the functions of the c-terminal domain of apc, we have investigated apc ( 1638t/1638t ) mice, which express a truncated apc that lacks the c-terminal domain. apc ( 1638t/1638t ) mice are tumor free and exhibit growth retardation. in the present ... | 2011 | 22179183 |
| the outcome of laparoscopic colorectal resection in t4 cancer. | aim:ôçé laparoscopic surgery for locally advanced tumours with extramural involvement is still controversial. it is believed that laparoscopic excision of t4 cancers is technically difficult and may result in prolonged operative time, increased conversion rate, added post-operative morbidity, and suboptimal oncological clearance. method:ôçé our unit has been practising laparoscopic colorectal surgery since 1992, and all data are entered into a database prospectively. since 1999 we have routinely ... | 2011 | 21689365 |
| thyroid function during critical illness. | the metabolic support of the critically ill patient is a relatively new target of active research and little is as yet known about the effects of critical illness on metabolism. the nonthyroidal illness syndrome, also known as the low t3 syndrome or euthyroid sick syndrome, describes a condition characterized by abnormal thyroid function tests encountered in patients with acute or chronic systemic illnesses. the laboratory parameters of this syndrome include low serum levels of triiodothyronine ... | 2011 | 21724536 |
| evaluation of effect of isoflavone on thyroid economy & autoimmunity in oophorectomised women: a randomised, double-blind, placebo-controlled trial. | the potential of soy isoflavones to interfere with thyroid function has been reported. however, there are limited data regarding their effect on thyroid function and autoimmunity in surgical menopausal women. the present study aimed to evaluate the effect of isoflavones on thyroid function and autoimmunity, menopausal symptoms, serum follicle stimulating hormone (fsh) and estradiol levels in oophorectomised women. | 2011 | 21727662 |
| predictive factors for pulmonary metastases after curative resection of rectal cancer without preoperative chemoradiotherapy. | the aim of this study was to clarify the actuarial incidence of pulmonary metastases and risk factors for pulmonary metastases after curative resection of rectal cancer without preoperative chemoradiotherapy. | 2011 | 21730788 |
| Disaster metrics: quantitative benchmarking of hospital surge capacity in trauma-related multiple casualty events. | Objectives:-á Hospital surge capacity in multiple casualty events (MCE) is the core of hospital medical response, and an integral part of the total medical capacity of the community affected. To date, however, there has been no consensus regarding the definition or quantification of hospital surge capacity. The first objective of this study was to quantitatively benchmark the various components of hospital surge capacity pertaining to the care of critically and moderately injured patients in tra ... | 2011 | 21685307 |
| Extent of lung resection in non-small lung cancer with interlobar lymph node involvement. | Optimal resection type for non-small cell lung cancer (NSCLC) with interlobar lymph node involvement (ILNI) has seldom been reported. To completely resect a NSCLC with ILNI, some surgeons believe that a pneumonectomy is needed. | 2011 | 21697782 |
| Insights into molecular properties of the human monocarboxylate transporter 8 by combining functional with structural information. | The monocarboxylate transporter 8 (MCT8) is a member of the major facilitator superfamily (MFS) and transports specificly iodothyronines. MCT8 mutations are the underlying cause of a syndrome of severe X-linked psychomotor retardation known as the Allan-Herndon-Dudley syndrome. This syndrome is characterized by abnormally high T3, low/normal T4 serum levels and slightly elevated serum TSH. To date, more than 25 pathogenic mutations in hMCT8 are known and they are valuable indicators of important ... | 2011 | 21835051 |
| Circumferential Resection Margin Involvement after Laparoscopic Abdominoperineal Resection for Rectal Cancer. | Aim:ÔÇé This study aimed to evaluate circumferential resection margin (CRM) involvement in patients with rectal adenocarcinoma after laparoscopic abdominoperineal resection (APR). Method:ÔÇé Prospectively collected data were analyzed on consecutive patients who underwent laparoscopic APR for histologically-proven rectal cancer following neoadjuvant chemotherapy from 1998 to 2006. Patients with no sphincter involvement were not included and underwent intersphincteric resection with coloanal anast ... | 2011 | 21689315 |
| the pharmacists' role in improving guideline compliance for thyroid function testing in patients with heart failure. | this single-center retrospective pilot program's objective was to utilize outpatient pharmacists to improve laboratory test adherence in chronic heart failure (chf) patients overdue for thyroid function testing, thereby demonstrating the value of the outpatient pharmacist and justifying possible clinical role expansion. thyroid disorders may contribute to chf development, progression, and exacerbation. testing is the standard of care in chf patients per american heart association's 2009 guidelin ... | 2011 | 21844214 |
| The evaluation of SOX9 expression and its relationship with carcinoembryonic antigen-related cell adhesion molecule 1 in gastric neoplastic and nonneoplastic lesions. | The aims of this study were to investigate the expression of SOX9 (sex determining region Y [SRY]-related high-mobility group box 9) and carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in benign, premalignant, and malignant gastric lesions and to explore the association between SOX9 and CEACAM1 in gastric carcinogenesis. SOX9 and CEACAM1 expression was detected in normal gastric mucosa, hyperplastic polyp, intestinal metaplasia, gastric intraepithelial neoplasia, and adenocar ... | 2011 | 22209504 |
| Solution structure of a minor and transiently formed state of a T4 lysozyme mutant. | Proteins are inherently plastic molecules, whose function often critically depends on excursions between different molecular conformations (conformers). However, a rigorous understanding of the relation between a protein's structure, dynamics and function remains elusive. This is because many of the conformers on its energy landscape are only transiently formed and marginally populated (less than a few per cent of the total number of molecules), so that they cannot be individually characterized ... | 2011 | 21857680 |
| oral maxillary squamous carcinoma: an indication for neck dissection in the clinically negative neck. | this multicenter study was undertaken to characterize the metastatic behavior of oral maxillary squamous carcinoma and to determine the role of selective neck dissection. | 2011 | 21990223 |
| impact of subclinical hypothyroidism treatment in systolic and diastolic cardiac function. | to evaluate the effects of levothyroxine (l-t4) replacement in echocardiographic parameters of middle-aged women with subclinical hypothyroidism (sh). | 2011 | 22147094 |
| Plasma progesterone, metabolic hormones and beta-hydroxybutyrate in Holstein-Friesian cows after superovulation. | Metabolic hormones [insulin, leptin, insulin-like growth factor-I (IGF-I), thyroxine (T4) and triiodothyronine (T3)], progesterone (P4) and beta-hydroxybutyrate (BHB) serum concentrations were evaluated and their effect on the superovulation results of donor cows was investigated in a semi-arid environment. Body weight, body condition score (BCS) and lactation stage were also included in the analysis. Twenty-three Holstein-Friesian cows were superovulated with 600 IU FSHp following the routine p ... | 2011 | 22079709 |
| thoracic paravertebral block for video-assisted thoracoscopic surgery: single injection versus multiple injections. | thoracic paravertebral blocks (pvbs) have been shown to be effective for analgesia after video-assisted thoracoscopic surgery (vats) with single- and multiple-injection techniques. the efficacy of single-injection pvb was compared with multiple-injection pvb on postoperative analgesia in vats was studied. | 2011 | 22055006 |
| effects of sitting up for five minutes versus immediately lying down after spinal anesthesia for cesarean delivery on fluid and ephedrine requirement; a randomized trial. | patient position after spinal anesthesia has had variable effects on blood pressure and ephedrine requirements. the aim of this study was to determine the effects that sitting the patient up for five minutes after spinal anesthesia would have on intraoperative fluid and ephedrine requirements. | 2011 | 21971743 |
| treatment of chronic chest wall pain in a patient with loeys-dietz syndrome using spinal cord stimulation. | spinal cord stimulation (scs) has been used with increased frequency for the treatment of intractable pain including chronic chest pain. | 2011 | 21992158 |
| concomitant boost radiotherapy and multidrug chemotherapy in the neoadjuvant treatment of locally advanced rectal cancer: results of a phase ii study. | an intensified multidrug chemotherapy regimen (raltitrexed plus oxaliplatin, tom-ox) plus concomitant boost radiotherapy, in the neoadjuvant treatment of locally advanced rectal cancer patients, was shown feasible in our previous study. the aim of this study was to evaluate the efficacy in terms of pathologic complete response to pre-operative therapy. | 2011 | 21851185 |
| Prevalence of acanthamoeba from tap water in rio grande do Sul, Brazil. | A total of 136 samples of tap water were collected from state and municipal schools between March and November 2009. The samples were filtered through cellulose nitrate membranes that were seeded at non-nutrient agar 1.5% containing an overlayer of Escherichia coli suspension. Thirty-one (22.79%) tap water samples investigated were found positive for free-living amoebae (FLA). From these, 13 presented as FLA that seems to belong to the genus Acanthamoeba. All samples of FLA were cloned and ident ... | 2011 | 21882008 |
| Pilot study: individualized training for caregivers of hospitalized older veterans. | : The hospital-to-home transition represents a vulnerable time for older veterans who are more medically and socioeconomically challenged than the general population of older adults. | 2011 | 22067595 |
| Evaluation of hybrid treatments to produce high quality reuse water. | Four tertiary hybrid treatments to produce high quality reused water, fulfilling Brazilian drinking water regulations, from a slaughterhouse's secondary treated effluent were evaluated. The pilot plant with a capacity of 500 L h(-1) was set up and consisted of these stages: pre-filtration system (cartridge filter 50 micron, activated carbon filter, cartridge filter 10 micron), oxidation (H2O2) or second filtration (ceramic filter, UF) followed by UV radiation (90 L h(-1)). The best combination w ... | 2011 | 21902048 |
| phase ii trial of preoperative chemotherapy with docetaxel, cisplatin and s-1 for t4 locally advanced gastric cancer. | the standard treatment for t4 locally advanced gastric cancer is gastrectomy with d2 lymph node dissection followed by adjuvant chemotherapy with s-1 for 12 months; however, prognostic outcome in stage iiib has been insufficient. it is expected that survival is improved by preoperative treatment with a triplet regimen of docetaxel, cisplatin and s-1 (divided dcs therapy). a multicenter phase ii study has been conducted to evaluate the safety and efficacy of two courses of preoperative chemothera ... | 2011 | 22167664 |
| Prediction of long-term disability in multiple sclerosis. | Background: Little is known about the predictive value of neurophysiological measures for the long-term course of multiple sclerosis (MS). Objective: To prospectively investigate whether combined visual (VEP) and motor evoked potentials (MEP) allow prediction of disability over 14 years. Methods: A total of 30 patients with relapsing-remitting and secondary progressive MS were prospectively investigated with VEPs, MEPs and the Expanded Disability Status Scale (EDSS) at entry (T0) and after 6, 12 ... | 2011 | 21868486 |