Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| phase ii trial of preoperative chemotherapy with docetaxel, cisplatin and s-1 for t4 locally advanced gastric cancer. | the standard treatment for t4 locally advanced gastric cancer is gastrectomy with d2 lymph node dissection followed by adjuvant chemotherapy with s-1 for 12 months; however, prognostic outcome in stage iiib has been insufficient. it is expected that survival is improved by preoperative treatment with a triplet regimen of docetaxel, cisplatin and s-1 (divided dcs therapy). a multicenter phase ii study has been conducted to evaluate the safety and efficacy of two courses of preoperative chemothera ... | 2011 | 22167664 |
| Prediction of long-term disability in multiple sclerosis. | Background: Little is known about the predictive value of neurophysiological measures for the long-term course of multiple sclerosis (MS). Objective: To prospectively investigate whether combined visual (VEP) and motor evoked potentials (MEP) allow prediction of disability over 14 years. Methods: A total of 30 patients with relapsing-remitting and secondary progressive MS were prospectively investigated with VEPs, MEPs and the Expanded Disability Status Scale (EDSS) at entry (T0) and after 6, 12 ... | 2011 | 21868486 |
| EFFECT OF GLUCOCORTICOID ADMINISTRATION ON ADRENAL GLAND SIZE AND SONOGRAPHIC APPEARANCE IN BEAGLE DOGS. | Our aim was to evaluate the influence of glucocorticoids on the adrenal gland using ultrasonography. Eleven healthy beagles were used in a prospective placebo-controlled study. All dogs received hydrocortisone at 10 mg/kg twice a day per os for 4 months or a gelatin capsule twice a day per os as a placebo. Clinical and endocrinologic examination of the dogs and ultrasonographic evaluation of adrenal echogenicity, shape, and measurement of the length and height of the cranial and caudal pole were ... | 2011 | 22092685 |
| Sensillum-specific, topographic projection patterns of olfactory receptor neurons in the antennal lobe of the cockroach Periplaneta americana. | In vertebrates and many invertebrates, olfactory signals detected by peripheral olfactory receptor neurons (ORNs) are conveyed to a primary olfactory center with glomerular organization in which odor specific activity patterns are generated. In the cockroach, Periplaneta americana, ORNs in antennal olfactory sensilla project to 205 unambiguously identifiable antennal lobe (AL) glomeruli that are classified into 10 glomerular clusters (T1-T10 glomeruli) innervated by distinct sensory tracts. In t ... | 2011 | 22121009 |
| critical behavior of megabase-size dna toward the transition into a compact state. | we studied the changes in the higher-order structure of a megabase-size dna (s120-1 dna) under different spermidine (spd) concentrations through single-molecule observations using fluorescence microscopy (fm) and atomic force microscopy (afm). we examined the difference between the folding transitions in s120-1 dna and sub-megabase-size dna, t4 dna (166 kbp). from fm observations, it is found that s120-1 dna exhibits intra-chain segregation as the intermediate state of transition, in contrast to ... | 2011 | 22168726 |
| t⁴ workshop report. nanotoxicology: "the end of the beginning" - signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials. | in october 2010, a group of experts met as part of the transatlantic think tank for toxicology (t4) to exchange ideas about the current status and future of safety testing of nanomaterials. at present, there is no widely accepted path forward to assure appropriate and effective hazard identification for engineered nanomaterials. the group discussed needs for characterization of nanomaterials and identified testing protocols that incorporate the use of innovative alternative whole models such as ... | 2011 | 21993959 |
| probing the substrate specificity of the bacterial pnkp/hen1 rna repair system using synthetic rnas. | ribotoxins cleave essential rnas involved in protein synthesis as a strategy for cell killing. rna repair systems exist in nature to counteract the lethal actions of ribotoxins, as first demonstrated by the rna repair system from bacteriophage t4 25 yr ago. recently, we found that two bacterial proteins, named pnkp and hen1, form a stable complex and are able to repair ribotoxin-cleaved trnas in vitro. however, unlike the well-studied t4 rna repair system, the natural rna substrates of the bacte ... | 2011 | 22190744 |
| changes of thyroid hormone levels and related gene expression in zebrafish on early life stage exposure to triadimefon. | in this study, zebrafish was exposed to triadimefon. thyroid hormones levels and the expression of related genes in the hypothalamic-pituitary-thyroid (hpt) axis, including thyroid-stimulating hormone (tsh-beta), deiodinases (dio1 and dio2) and the thyroid hormone receptor (thraa and thrb) were evaluated. after triadimefon exposure, increased t4 can be explained by increased thyroid-stimulating hormone (tsh-beta). the conversion of t4 to t3 (deiodinase type i-dio1) was decreased, which reduced t ... | 2011 | 22004968 |
| Proximal and distal rectal cancers differ in curative resectability and local recurrence. | To evaluate patients with proximal rectal cancer (PRC) (> 6 cm up to 12 cm) and distal rectal cancer (DRC) (0 to 6 cm from the anal verge). | 2011 | 22007278 |
| our experience in the treatment advanced neoplasms of floor of the mouth. | aim: the aim of this study was to evaluate results of our surgical treatment of advanced neoplasms of the floor of the mouth, treated from 2005-2011 in department of otolaryngology and department of plastic surgery medical university of gdańsk material: we analyzed group of 12 patients (aged 36 to 70 years, mean 55) treated by primary surgical excision of neoplasms of the floor of the mouth (with tracheotomy and mandibulotomy) and selective or radical neck dissection (uni- or bilateral) in combi ... | 2011 | 22078284 |
| prognostic factors (including hpv status) for irradiation of locally advanced squamous cell carcinoma of the head and neck (scchn). | the prognosis of patients with locally advanced squamous cell carcinoma of the head and neck (scchn) is generally poor. however, prognostic factors can help optimize the care for the individual patient. this study investigated potential prognostic factors, including hpv status, for locoregional control (lrc), metastases-free survival (mfs), and survival (os). | 2011 | 21932027 |
| Schistosoma japonicum: treatment of different developmental stages in mice with long-acting praziquantel implants. | This paper reports the effective treatment of Schistosoma japonicum in a mouse model with long-acting praziquantel (PZQ)-loaded poly(e-caprolactone) implants. The implants yielded stable, high plasma PZQ concentrations ranging 100-1600 ng/mL during the 40-day investigation period. For assessment of efficacy, the implants were implanted into mice immediately after infection and at 1, 2, 3 and 4 weeks after infection to treat the schistosomes at different developmental stages. All the mice were sa ... | 2011 | 21856298 |
| Preterm birth and Assisted Reproductive Technology/ART: Maternal emotional wellbeing and quality of mother-newborn interaction during the first three months of life. | OBJECTIVE: Assisted Reproductive Technology (ART) and premature birth are stressful and difficult experiences for women. No research to date has examined the impact of ART on mother-child relationship in instances of preterm delivery. This study explored the psychological status of preterm infants' ART-mothers and the quality of mother-infant dyadic interaction, up to child age of three months (Corrected Age = CA). METHOD: Forty-one ART-dyads and 53 Spontaneous Pregnancy (SP) dyads were enrolled ... | 2011 | 22055247 |
| predictive value of baseline neutrophil/lymphocyte ratio for t4 disease in wall-penetrating gastric cancer. | multimodality therapy has been used in the management of gastric cancer associated with locoregional spread. however, the accurate clinical staging still remains to be established. the neutrophil/lymphocyte ratio (nlr) in the peripheral blood is reported to be an easily assessable prognostic factor in cancer patients. we evaluated the predictive significance of the nlr and other serological parameters in patients with wall-penetrating gastric cancer. | 2011 | 21913135 |
| the outcome of laparoscopic colorectal resection in t4 cancer. | aim:ôçé laparoscopic surgery for locally advanced tumours with extramural involvement is still controversial. it is believed that laparoscopic excision of t4 cancers is technically difficult and may result in prolonged operative time, increased conversion rate, added post-operative morbidity, and suboptimal oncological clearance. method:ôçé our unit has been practising laparoscopic colorectal surgery since 1992, and all data are entered into a database prospectively. since 1999 we have routinely ... | 2011 | 21689365 |
| thyroid function during critical illness. | the metabolic support of the critically ill patient is a relatively new target of active research and little is as yet known about the effects of critical illness on metabolism. the nonthyroidal illness syndrome, also known as the low t3 syndrome or euthyroid sick syndrome, describes a condition characterized by abnormal thyroid function tests encountered in patients with acute or chronic systemic illnesses. the laboratory parameters of this syndrome include low serum levels of triiodothyronine ... | 2011 | 21724536 |
| evaluation of effect of isoflavone on thyroid economy & autoimmunity in oophorectomised women: a randomised, double-blind, placebo-controlled trial. | the potential of soy isoflavones to interfere with thyroid function has been reported. however, there are limited data regarding their effect on thyroid function and autoimmunity in surgical menopausal women. the present study aimed to evaluate the effect of isoflavones on thyroid function and autoimmunity, menopausal symptoms, serum follicle stimulating hormone (fsh) and estradiol levels in oophorectomised women. | 2011 | 21727662 |
| predictive factors for pulmonary metastases after curative resection of rectal cancer without preoperative chemoradiotherapy. | the aim of this study was to clarify the actuarial incidence of pulmonary metastases and risk factors for pulmonary metastases after curative resection of rectal cancer without preoperative chemoradiotherapy. | 2011 | 21730788 |
| Disaster metrics: quantitative benchmarking of hospital surge capacity in trauma-related multiple casualty events. | Objectives:-á Hospital surge capacity in multiple casualty events (MCE) is the core of hospital medical response, and an integral part of the total medical capacity of the community affected. To date, however, there has been no consensus regarding the definition or quantification of hospital surge capacity. The first objective of this study was to quantitatively benchmark the various components of hospital surge capacity pertaining to the care of critically and moderately injured patients in tra ... | 2011 | 21685307 |
| Extent of lung resection in non-small lung cancer with interlobar lymph node involvement. | Optimal resection type for non-small cell lung cancer (NSCLC) with interlobar lymph node involvement (ILNI) has seldom been reported. To completely resect a NSCLC with ILNI, some surgeons believe that a pneumonectomy is needed. | 2011 | 21697782 |
| Insights into molecular properties of the human monocarboxylate transporter 8 by combining functional with structural information. | The monocarboxylate transporter 8 (MCT8) is a member of the major facilitator superfamily (MFS) and transports specificly iodothyronines. MCT8 mutations are the underlying cause of a syndrome of severe X-linked psychomotor retardation known as the Allan-Herndon-Dudley syndrome. This syndrome is characterized by abnormally high T3, low/normal T4 serum levels and slightly elevated serum TSH. To date, more than 25 pathogenic mutations in hMCT8 are known and they are valuable indicators of important ... | 2011 | 21835051 |
| Circumferential Resection Margin Involvement after Laparoscopic Abdominoperineal Resection for Rectal Cancer. | Aim:ÔÇé This study aimed to evaluate circumferential resection margin (CRM) involvement in patients with rectal adenocarcinoma after laparoscopic abdominoperineal resection (APR). Method:ÔÇé Prospectively collected data were analyzed on consecutive patients who underwent laparoscopic APR for histologically-proven rectal cancer following neoadjuvant chemotherapy from 1998 to 2006. Patients with no sphincter involvement were not included and underwent intersphincteric resection with coloanal anast ... | 2011 | 21689315 |
| the pharmacists' role in improving guideline compliance for thyroid function testing in patients with heart failure. | this single-center retrospective pilot program's objective was to utilize outpatient pharmacists to improve laboratory test adherence in chronic heart failure (chf) patients overdue for thyroid function testing, thereby demonstrating the value of the outpatient pharmacist and justifying possible clinical role expansion. thyroid disorders may contribute to chf development, progression, and exacerbation. testing is the standard of care in chf patients per american heart association's 2009 guidelin ... | 2011 | 21844214 |
| staged approach prevents spinal cord injury in hybrid surgical-endovascular thoracoabdominal aortic aneurysm repair: an experimental model. | in a porcine model, we investigated the impact of sudden stent graft occlusion of thoracic intercostal arteries after open lumbar segmental artery (sa) ligation. | 2011 | 21718839 |
| sustained control of graves' hyperthyroidism during long-term low-dose antithyroid drug therapy of patients with severe graves' orbitopathy. | background: patients with severe graves' orbitopathy often have hyperthyroidism that is difficult to treat and a high proportion of patients experience relapse of hyperthyroidism after a course of antithyroid drug (atd) therapy of fixed duration. the aim of the study was to evaluate the feasibility of prolonged low-dose atd therapy for attaining stable euthyroidism in patients with severe graves' orbitopathy and hyperthyroidism. methods: we performed retrospective analyses of data collected duri ... | 2011 | 21834677 |
| accelerated radiotherapy and concomitant high dose chemotherapy in non resectable stage iv locally advanced hnscc: results of a gortec randomized trial. | the objective was to evaluate the efficacy of a strong increase of the dose-intensity of concomitant radio-chemotherapy (rt-ct) in patients with far advanced non metastatic hnscc. | 2011 | 21831465 |
| neoadjuvant gemcitabine and cisplatin chemotherapy for locally advanced urothelial cancer of the bladder. | background: the purpose of this study was to investigate the effect of neoadjuvant chemotherapy with gemcitabine and cisplatin (gc) on pathologic down-staging of patients with locally advanced urothelial cancer (uc) of the bladder. methods: this was a retrospective cohort study of patients treated with radical cystectomy (rc) for clinical stage ct2-t4, n any, m0 bladder uc at strong memorial hospital from 1999 to 2009. the primary exposure variable was use of neoadjuvant chemotherapy (gc vs none ... | 2011 | 21720989 |
| apical-node metastasis in sigmoid colon or rectal cancer: is it a factor that indicates a poor prognosis after high ligation? | purpose: the prognostic significance of apical-node metastasis around the inferior mesenteric artery (ima) remains unclear. we investigated the oncological relevance of apical-node metastasis detected after high ligation of the ima in stage iii sigmoid colon or rectal cancer. methods: between may 2003 and december 2007, 229 consecutive patients with stage iii sigmoid colon or rectal cancer, who had undergone curative resection with high ligation, were analyzed. cox proportional regression model ... | 2011 | 21739197 |
| disseminated tumor cells predict survival after neoadjuvant therapy in primary breast cancer. | background: tumor cells that disseminate to the bone marrow (disseminated tumor cells [dtcs]) have been identified in 30% of patients with stage i through ii breast cancer (bc) and predict outcome. neoadjuvant chemotherapy (nact) is effective in reducing the size of primary tumors or eradicating lymph node metastases before surgery, but little is known regarding the presence or significance of dtcs after nact. methods: the authors evaluated dtcs in 95 patients with clinical stage i through iii b ... | 2011 | 21717428 |
| responses of growing japanese quails that received selenium from selenium enriched kale sprout (brassica oleracea var. alboglabra l.). | the objectives of this study were to determine the effect of selenium (se) from se-enriched kale sprout (brassica oleracea var. alboglabra l.) on the performance and se concentrations in tissues of growing japanese quails. two hundred quails were divided into five treatments. each treatment consisted of four replicates and each replicate contained ten quails in a completely randomize design. the experiment was conducted for 5-áweeks. the treatments were t1, control diet; t2, control diet plus 0. ... | 2011 | 21681467 |
| impact of severity, duration, and etiology of hyperthyroidism on bone turnover markers and bone mineral density in men. | abstract: background: hyperthyroidism is accompanied by osteoporosis with higher incidence of fracture rates. the present work aimed to study bone status in hyperthyroidism and to elucidate the impact of severity, duration, and etiology of hyperthyroidism on biochemical markers of bone turnover and bone mineral density (bmd). methods: fifty-two male patients with hyperthyroidism, 31 with graves' disease (gd) and 21 with toxic multinodular goiter (tng), with an age ranging from 23 to 65 years wer ... | 2011 | 21819612 |
| thyroid hormone transport in developing brain. | to discuss the recent advances on thyroid hormone transport in the brain. a special attention is paid to the x-linked thyroid hormone cell transport (thct) defect (also known as the allan-herndon-dudley syndrome), caused by mutations of the specific thyroid hormone transporter mct8 gene. | 2011 | 21825978 |
| lateral spine radiographs before androgen deprivation treatment detect a high incidence of undiagnosed vertebral fragility fractures in men with advanced prostate cancer. | baseline bone mineral density scanning in patients about to commence long-term androgen deprivation therapy for advanced/metastatic prostate cancer is reported to show a high incidence of osteoporosis and osteopenia. we investigated the incidence of existing spinal osteoporotic fractures in this population as this is known to be a risk factor for the development of treatment induced fractures. | 2011 | 21705031 |
| tranilast prevents the progression of chronic cyclosporine nephrotoxicity through regulation of transforming growth factor +¦/smad pathways. | our aim was to investigate the role of tranilast in transforming growth factor (tgf) +¦/smad pathways using a rat model of chronic cyclosporine (csa) nephrotoxicity. | 2011 | 21693312 |
| the follow up of radioiodine treated hyperthyroid patients: should thyroid function be monitored more frequently? | background: there is a lack of data regarding the timing and particularly the severity of hypothyroidism post radioiodine (ri). aim: to investigate the timing and severity of hypothyroidism in ri treated hyperthyroid patients. methods: retrospective examination of the records of 183 ri treated hyperthyroid patients (79 patients autoimmune hyperthyroidism, 46 toxic mng and 58 hyperthyroidism of indeterminate aetiology). results: 159 patients requiring a single dose of ri (435 mbq), 107 (67%) deve ... | 2011 | 21720207 |
| metastatic potential in renal cell carcinomas ôëñ7cm: swedish kidney cancer quality register data. | background: renal cell carcinoma (rcc) represents 2-3% of all malignancies and accounts for approximately 90% of all kidney malignancies. an increasing proportion of rccs are discovered incidentally, and the average tumor diameter at diagnosis has decreased over the last few decades. small rccs have often been regarded by many as relatively harmless. objective: the objective was to evaluate the incidence of local t-category distribution and lymph node and distant metastases in relation to tumor ... | 2011 | 21741160 |
| levothyroxine monotherapy cannot guarantee euthyroidism in all athyreotic patients. | levothyroxine monotherapy is the treatment of choice for hypothyroid patients because peripheral t4 to t3 conversion is believed to account for the overall tissue requirement for thyroid hormones. however, there are indirect evidences that this may not be the case in all patients. | 2011 | 21829633 |
| type 2 deiodinase at the crossroads of thyroid hormone action. | thyroid hormone action can be customized on a cell-specific fashion through the controlled action of the deiodinase group of enzymes, which are homodimeric thioredoxin fold containing selenoproteins. whereas the type ii deiodinase (d2) initiates thyroid hormone signaling by activating the pro-hormone thyroxine (t4) to the biologically active t3 molecule, the type iii deiodinase (d3) terminates thyroid hormone action by catalyzing the inactivation of both t4 and t3 molecules. deiodinases play a r ... | 2011 | 21679772 |
| [vertical trapezius myocutaneous flap for repairing soft tissue defect after head and neck tumor resection]. | to introduce the experience of the clinical application of vertical trapezius myocutaneous flap in repairing soft tissue defects after head and neck tumor resection. | 2011 | 21675112 |
| [therapy of thoracolumbar vertebra tumor by total spondylectomy and spine reconstruction through posterior approach]. | to explore the surgical procedure and effectiveness of total spondylectomy and spine reconstruction through posterior approach to treat thoracolumbar vertebra tumor. | 2011 | 21675110 |
| differential bacteriophage mortality on exposure to copper. | many studies report that copper can be used to control microbial growth, including that of viruses. we determined the rates of copper-mediated inactivation for a wide range of bacteriophages. we used two methods to test the effect of copper on bacteriophage survival. one method involved placing small volumes of bacteriophage lysate on copper and stainless steel coupons. following exposure, metal coupons were rinsed with lysogeny broth and the resulting fluid was serially diluted and plated on ag ... | 2011 | 21841029 |
| combination of differentiation and t stage can predict unresponsiveness to neoadjuvant therapy for rectal cancer. | aimôçé the study aimed to identify the factors predictive for extreme unresponsiveness to neoadjuvant therapy for rectal cancer. methodôçé ninety-six patients with rectal cancer received neoadjuvant therapy before surgery (41 radiotherapy; 55 chemoradiotherapy). tumour response, down staging, pathological complete response (pcr) and disease-free survival were evaluated. resultsôçé tumour response, down-staging and pcr occurred in 70 (72.9%), 47 (49.0%) and 14 (14.6%) patients. univariate analyse ... | 2011 | 21689282 |
| the effect of trauma on stress reactivity in aggressive youth. | to address gaps in the literature related to the contribution of childhood trauma on aggression we evaluated salivary cortisol and heart rate changes to psychological challenge in aggressive children with various degrees of trauma. we hypothesized that traumatized and aggressive youths will exhibit higher responsiveness to an active challenge (violent film-vf) than aggressive youth with no trauma but will not differ when viewing a non-violent film (nvf). a total of 25 children (aged 9-12; m=15, ... | 2011 | 21684014 |
| seom clinical guidelines for the treatment of invasive bladder cancer. | the purpose of this article is to provide updated recommendations for the diagnosis and treatment of muscle- invasive and metastatic bladder cancer. the diagnosis of muscle-invasive bladder cancer is made by transurethral resection and following histopathologic evaluation. invasive bladder cancer should be staged according to the uicc system. patients with confirmed muscle-invasive bladder cancer should be staged by computed tomography scans of the chest, abdomen and pelvis. radical cystectomy i ... | 2011 | 21821489 |
| morphologic evaluation of the thoracic vertebrae for safe free-hand pedicle screw placement in adolescent idiopathic scoliosis: a ct-based anatomical study. | objective: to evaluate the morphologic characteristics of the thoracic pedicle with regard to safe free-hand thoracic pedicle screw placement, based on multi-planar reconstruction ct images. methods: thirty adolescent idiopathic scoliosis (ais) patients who had undergone posterior corrective surgery for major thoracic curve were included in this study. reconstructed ct axial images at each thoracic vertebra were used to measure: (1) the shortest distance from an entry point to the ventral cortex ... | 2011 | 21739245 |
| zoster myelitis in sickle cell anemia. | a 17-year-old female patient, known case of sickle cell anemia was admitted to our hospital with 10 days history of fever, vomiting, and epigastric pain. on examination, her temperature was 38-¦c. there was a vesicular type of rash below the nipple and over the left chest involving the back. she was diagnosed as herpes zoster and was started on acyclovir with good hydration and analgesia. three days later, she developed weakness and decreased sensation of the right leg. on the fifth day, examina ... | 2011 | 21677622 |
| [clinical significance of radical cystectomy with extended lymphadenectomy]. | to evaluate the prognosis of patients treated with radical cystectomy and extended lymphadenectomy for invasive bladder cancer and to describe the association of the primary bladder tumor grade, stage, lymph node status and lymph node density with clinical outcomes. | 2011 | 21844970 |
| thyroid hormone regulation by stress and behavioral differences in adult male rats. | thyroid hormones are essential regulators of growth, development and normal bodily function and their release is coordinated by the hypothalamic-pituitary-thyroid (hpt) axis. while the hpt axis has been established as an acutely stress-responsive neuroendocrine system, relatively little is known about the mechanisms of its stress regulation. the present study examined acute stress-induced changes in peripheral hormone levels [triiodothyronine (t3); thyroxine (t4), thyroid-stimulating hormone (ts ... | 2011 | 21689656 |
| mental adjustment to cancer and its relation to anxiety, depression, hrql and survival in patients with laryngeal cancer - a longitudinal study. | using a longitudinal design, aim of this study was to investigate the relation between mental adjustment to cancer and anxiety, depression, health-related quality of life (hrql) and survival in patients treated for laryngeal cancer. | 2011 | 21718478 |
| overexpression of sirt1 in mouse forebrain impairs lipid/glucose metabolism and motor function. | sirt1 plays crucial roles in glucose and lipid metabolism, and has various functions in different tissues including brain. the brain-specific sirt1 knockout mice display defects in somatotropic signaling, memory and synaptic plasticity. and the female mice without sirt1 in pomc neuron are more sensitive to diet-induced obesity. here we created transgenic mice overexpressing sirt1 in striatum and hippocampus under the control of camkii+¦ promoter. these mice, especially females, exhibited increas ... | 2011 | 21738790 |
| Phenothiourea sensitizes zebrafish cranial neural crest and extraocular muscle development to changes in retinoic acid and IGF signaling. | 1-Phenyl 2-thiourea (PTU) is a tyrosinase inhibitor commonly used to block pigmentation and aid visualization of zebrafish development. At the standard concentration of 0.003% (200 µM), PTU inhibits melanogenesis and reportedly has minimal other effects on zebrafish embryogenesis. We found that 0.003% PTU altered retinoic acid and insulin-like growth factor (IGF) regulation of neural crest and mesodermal components of craniofacial development. Reduction of retinoic acid synthesis by the pan-alde ... | 2011 | 21886774 |
| Soft tissue stability in segmental distraction of the anterior mandibular alveolar process. A 2-year follow-up. | This study evaluated soft tissue changes in adult patients treated with distraction osteogenesis (DOG) of the anterior mandibular alveolar process and related it to different parameters. 33 patients (27 females; 6 males) were analysed retrospectively before surgery at T1 (17.0 days), after surgery at T2 (mean 6.5 days), at T3 (mean 24.4 days), and at T4 (mean 2.0 years). Lateral cephalograms were traced by hand, digitized, superimposed, and evaluated. Statistical analysis was carried out using K ... | 2011 | 22204924 |
| A transgenic approach to identify thyroxine transporter-expressing structures in brain development. | Transporters are essential in thyroid hormone metabolism. Thyroxine (T4) is transported by solute carrier organic anion transporter 1c1 (SLCO1C1, OATP14) into the adult brain, where T4 is converted to 3,5,3'-triiodothyronine (T3). In adults, SLCO1C1 expression is found in two brain barrier structures: the blood-brain barrier (BBB) and choroid plexus. However, little is known about how T4 is transported in the developing brain, when the BBB is not yet completely formed. We employed bacterial arti ... | 2011 | 21910767 |
| microbial removal from the separated liquid fraction of anaerobically digested pig manure in meso-scale integrated constructed wetlands. | the aim was to investigate microbial removal from the liquid fraction of anaerobically digested pig manure in meso-scale integrated constructed wetlands (icw's) over a 13 month period. four treatments were investigated: t1 (standard), t2 (effluent recycling), t3 (high nutrient loading), and t4 (high flow rate). mean counts of yeasts and moulds and spore-forming bacteria were higher in t3 and t4 than in t1 and t2 (p<0.05). flow through the cells reduced mean counts of coliform, yeasts and moulds ... | 2011 | 21852121 |
| [type 1 diabetes impairs compensatory response after myocardial infarction; role of tissue hypothyroidism and effects of thyroid hormone administration]. | type 1 diabetes (tod) increases the risk of coronary artery disease and myocardial infarction and is characterized by baseline cardiac dysfunction. we investigated the influence of tod in post-infarct remodeling (rem) and the role of thyroid hormone (th) signaling in this response. acute myocardial infarction (ami) was induced in rats with type i diabetes (tod) and in non diabetic rats (ntod-ami), sham-operated rats serving as controls (sham). ami resulted in tissue hypothyroidism due to signifi ... | 2011 | 22039709 |
| metabolic pathways of tetraidothyronine and triidothyronine production by thyroid gland: a review of articles. | tetraidothyronine (t4) and triiodothyronine (t3) are the two vital hormones in human metabolism produced by thyroid gland. the major pathways in thyroid hormone biosynthesis begin with iodine metabolism which occurs in three sequential steps: active iodide transport into thyroid followed by iodide oxidation and subsequent iodination of tyrosyl residues of thyroglobulin (tg) to produce idotyrosines monoidotyrosine (mit) and diiodothyrosine (dit) on tg. oxidized iodine and tyrosyle residues which ... | 2011 | 21913492 |
| quantitative electroencephalography in schizophrenia and depression. | standard (qualitative) electroencephalography (eeg) is routinely used in the diagnostic evaluation of psychiatric patients. quantitative eeg (qeeg) findings differ between patients with schizophrenia, patients with depression, but results are not consistent. the aim of our study was to determine the differences in qeeg parameters between patients with schizophrenia, patients with depression, and healthy subjects. | 2011 | 22075736 |
| resolution of spam following cordectomy: implications for understanding pathophysiology. | study design:case report.objective:to describe the clinical benefit of a spinal cordectomy with the aim of limiting neurological deterioration related to the development of a subacute posttraumatic ascending myelopathy (spam) supporting previously described mechanism for spam formation.setting:national spinal injuries centre, stoke mandeville hospital, uk.method and results:a 38-year old patient presented 6 months after spinal cord injury substantial neurological deterioration expanding from the ... | 2011 | 22158252 |
| serum insulin-like growth factors and mortality in localised and advanced clinically detected prostate cancer. | many studies have reported associations of insulin-like growth factors (igfs) and igf-binding proteins (igfbps) with prostate cancer development, but none have investigated their association with fatal progression of prostate cancer. | 2011 | 22183619 |
| significance of mrna and protein expression of mac30 in progression of colorectal cancer. | background: meningioma-associated protein (mac30), first described to be overexpressed in meningiomas, exhibits altered expression in certain human tumors. the aim of our study was to investigate the expression of mac30 mrna and its correlation with clinicopathological variables in human colorectal cancer (crc). methods: mac30 mrna expression was first examined in 55 crcs, along with the samples from the matched distant normal and adjacent noncancerous tissue by rt-pcr, further verified in 18 cr ... | 2011 | 22024687 |
| Understanding narrative effects: the impact of breast cancer survivor stories on message processing, attitudes, and beliefs among African American women. | Examine the longitudinal effects of personal narratives about mammography and breast cancer compared with a traditional informational approach. | 2011 | 21895370 |
| Adverse Features on Rectal MRI Identify a High-risk Group that May Benefit from More Intensive Preoperative Staging and Treatment. | BACKGROUND: Magnetic resonance imaging (MRI) is highly accurate in local staging of rectal cancer. It can identify features known to be associated with increased risk of metastatic disease. We evaluated the incidence of synchronous metastatic disease on fludeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) and contrast-enhanced multiple-row detector computed tomography (ceMDCT) in MRI-stratified high- and low-risk rectal cancers. The aim was to determine the incidence of ... | 2011 | 21913017 |
| Sacropelvic Fixation With Iliosacral Screws: Applications and Results in Adult Spinal Deformities. | STUDY DESIGN:: Retrospective radiographic and clinical review. OBJECTIVE:: To determine the feasibility of iliosacral screw fixation in adult spinal deformations. SUMMARY OF BACKGROUND DATA:: Pelvic fixation is one of the most challenging instrumentation problems. The poor bone quality frequently found within the sacrum and the large lumbosacral loads with cantilever pullout forces across this region explain its frequent failure. METHODS:: Fourteen adult patients undergoing pelvic fixation using ... | 2011 | 22134734 |
| bilateral leg symptoms - the t10 syndrome? | prior studies have investigated the role of the sympathetic nervous system and the thoracic spine related to the upper extremities (known as the t4 syndrome). however, there is only little known about the role of the thoracic spine related to the lower extremities. in this case report, a patient with a heavy, tired feeling in both legs and hypomobile thoracic segments was treated with passive mobilisations of the thoracic spine. | 2011 | 21943505 |
| endothelial dysfunction and subclinical hypothyroidism : a brief review. | subclinical hypothyroidism (sh) is characterized by normal serum free t4 (ft4) and free t3 (ft3) levels and increased serum thyroid-stimulating hormone (tsh) levels. the relationship between sh and cardiovascular diseases has been one of the most popular topics recently. there is still some controversy concerning the cardiovascular impact of sh and management protocols. the vast majority of the studies so far published suggests that sh accelerates endothelial dysfunction through traditional effe ... | 2011 | 22186427 |
| outcome of opioid switching 4 weeks after discharge from a palliative care unit. | despite the favorable effects reported with opioid switching performed in a specialized unit in the short term, data on long-term basis are poor, particularly after discharging patients home or in other settings. research design and methods: the aim of this prospective study was to evaluate the long-term outcome of patients who were switched in an acute palliative care unit at a high volume of opioid switching. a consecutive sample of patients who underwent opioid substitution during admission i ... | 2011 | 22029619 |
| [advances of development of phage display systems]. | the phage display technology (pdt) was unique in genetic engineering and recombinant expression. the phage display systems (pds) were platforms (kits) composed of genetic modified phages, helper phages, and host bacteria. this review concisely summarized the development of four types of pds, based on m13, λ, t4, and t7 phages, in terms of phage molecular genetics and genetic (gene or genome) engineering. we addressed on the key components and their genetic (genomic) engineering for modifications ... | 2011 | 21993286 |
| Time course responses of serum GH, insulin, IGF-1, IGFBP1, and IGFBP3 concentrations after heavy resistance exercise in trained and untrained men. | To investigate the effect of heavy resistance exercise on IGF-1 system, 19 healthy trained men and 15 healthy untrained men volunteered to participate in this study. The subjects were randomly divided into experimental and control groups. Subjects of experimental groups were forced to perform a heavy resistance exercise with the intensity of 70-80% of 1RM in selected movements. The blood samples were taken from all subjects four times; before (T1), immediately after (T2), 5 (T3), and 8 (T4) hour ... | 2011 | 21983797 |
| Malignant melanoma in the elderly: different regional disease and poorer prognosis. | Purpose: Age is a poor prognostic factor in melanoma patients. Elderly melanoma patients have a different presentation and clinical course than younger patients. We evaluated the impact of age =70 years (yrs) on the diagnosis and natural history of melanoma.Methods: Retrospective review of 610 patients with malignant melanoma entered into a prospective sentinel lymph node (SLN) database, treated from June 1997 to June 2010. Disease characteristics and clinical outcomes were compared between pati ... | 2011 | 22084644 |
| Prognostic significance of breast cancer subtype and p53 overexpression in patients with locally advanced or high-risk breast cancer treated using upfront modified radical mastectomy with or without post-mastectomy radiation therapy. | BACKGROUND: Although post-mastectomy radiation therapy (PMRT) has shown benefits, its effects in patient subpopulations remain uncertain. Therefore, we assessed whether breast cancer subtype and p53 overexpression were associated with outcome after modified radical mastectomy (MRM), with or without PMRT. METHODS: We retrospectively analyzed the records of patients who underwent MRM, with or without PMRT, between January 1991 and December 2008. Patients were considered eligible if they had T3 or ... | 2011 | 21898181 |
| [A retrospective study about 11 cases of Esthesioneuroblastomas treated in Hospital Santa Creu i Sant Pau between 2000 and 2008 and literature review]. | INTRODUCTION. Esthesioneuroblastoma (ENB) is a very uncommon malignant tumor with a neuroectodermal origin that usually involves the anterior cranial fossa and nasal cavity. OBJECTIVES. To review our experience in the management of ENB and assess the validity of the histopathological diagnosis, modality of treatment and prognostic factors of the disease comparing our findings with the literature. METHODS. A retrospective study of 11 cases with the diagnosis of esthesioneuroblastoma treated in ou ... | 2011 | 22031159 |
| [A case of residual metastatic lymph node lesion following definitive chemoradiotherapy for t4 esophageal cancer, successfully treated by outpatient clinic-based sequential chemotherapy with docetaxel followed by s-1]. | Patients with T4 esophageal cancer generally have poor prognosis. Of these patients, prognosis of non-responder to chemoradiothrapy( CRT) is extremely poor. We report a case of residual lymph node metastasis following definitive CRT, which showed a good response to outpatient clinic-based chemotherapy consisting of docetaxel (DOC) followed by S-1 in a patient with T4 esophageal cancer. The patient was a 65-year-old man with the diagnosis of squamous cell carcinoma of the middle thoracic esophagu ... | 2011 | 22202394 |
| Retrospective evaluation of the use of amiodarone in dogs with arrhythmias (from 2003 to 2010). | Objectives: To evaluate the efficacy of amiodarone in dogs with refractory supraventricular and ventricular arrhythmias and to document the side effects in treated dogs. Methods: Records of 28 dogs were retrospectively searched to document indication for amiodarone administration, heart rate, alkaline phosphatase, alanine aminotransferase, thyroxine (T4) and thyroid stimulating hormone values before and after starting treatment and during follow-up periods. Results: Sixteen dogs with supraventri ... | 2011 | 22098072 |
| A rigid disulfide-linked nitroxide side chain simplifies the quantitative analysis of PRE data. | The measurement of (1)H transverse paramagnetic relaxation enhancement (PRE) has been used in biomolecular systems to determine long-range distance restraints and to visualize sparsely-populated transient states. The intrinsic flexibility of most nitroxide and metal-chelating paramagnetic spin-labels, however, complicates the quantitative interpretation of PREs due to delocalization of the paramagnetic center. Here, we present a novel, disulfide-linked nitroxide spin label, R1p, as an alternativ ... | 2011 | 21947919 |
| [Role of vascular endothelial active facters in gas exchange impairment induced by tourniquet and the effect of shenmai injection]. | To investigate the effect of Shenmai injection on vascular endothelial active facters nitric oxide (NO) and endothelin-1 (ET-1), and pulmonary gas exchange induced by tourniquet deflation in patients undergoing lower extremity surgery. | 2011 | 22066459 |
| Reversal of profound rocuronium or vecuronium-induced neuromuscular block with sugammadex in isoflurane-anaesthetised dogs. | This study evaluated the use of sugammadex for reversal of profound neuromuscular blockade induced with rocuronium or vecuronium in dogs. Anaesthesia was induced and maintained with isoflurane in oxygen in eight dogs on two occasions. Neuromuscular blockade was monitored using peroneal nerve stimulation and acceleromyography. Rocuronium 0.6mg/kg or vecuronium 0.1mg/kg was administered intravenously (IV), followed 5min later by sugammadex 8mg/kg IV. Lag and onset time of rocuronium and vecuronium ... | 2011 | 22030475 |
| Status of level IIb lymph nodes of the neck in squamous cell carcinoma of the oral tongue in patients who underwent modified radical neck dissection and lymph node sentinel biopsy. | Status of lymph nodes of level IIb was examined to identify the incidence of nodal metastasis and the lymphatic drainage in squamous cell carcinoma of the oral tongue in patients undergoing modified radical neck dissection (MRND) and sentinel node biopsy (SNB). Overall, 72 patients were divided into two groups; 38 patients (Group A) of any T and N+ or T3-T4- N0 stage underwent MRND. The surgical specimens were sent to the Pathology Department, divided into specific levels (I, IIa, IIb, III, IV, ... | 2011 | 22058590 |
| Subclinical hypothyroidism and its association with cardiovascular risk factors. | Subclinical hypothyroidism (SH) represents the mildest form of thyroid hormone deficiency and may be associated with adverse consequences [Subclinical hypothyroidism was defined as a TSH level > 4.0 mIU/L and a normal free thyroxine level 0.6-1.8 ng/dL]. The identification of patients with subclinical hypothyroidism having an increased cardiovascular risk (CVR) is important. The aim of the study was to evaluate atherosclerotic risk factors in patients with subclinical hypothyroidism. | 2011 | 22029187 |
| Statistical mechanics and molecular dynamics in evaluating thermodynamic properties of biomolecular recognition. | Molecular recognition plays a central role in biochemical processes. Although well studied, understanding the mechanisms of recognition is inherently difficult due to the range of potential interactions, the molecular rearrangement associated with binding, and the time and length scales involved. Computational methods have the potential for not only complementing experiments that have been performed, but also in guiding future ones through their predictive abilities. In this review, we discuss h ... | 2011 | 22082669 |
| characteristics of anemia in subclinical and overt hypothyroid patients. | thyroid hormones stimulate directly or indirectly growth of erythroid colonies through erythropoietin. anemia is often the first sign of hypothyroidism. hypothyroidism can cause a wide variety of anemic disorders. numerous mechanisms are involved in the pathogenesis of these anemias that can be microcytic, macrocytic and normocytic. we designed this study to investigate the anemia frequency and if present, etiology of anemia in hypothyroid patients. 100 patients with overt hypothyroid, 100 ... | 2011 | 22200582 |
| [The clinical effect of combination therapy for oral cancer with s-1, superselective intra-arterial chemotherapy, and radiation therapy]. | Combination therapy with S-1, superselective intra-arterial infusion of CBDCA and radiation therapy has been used to treat patients with oral cancer since 2005. In this study, the histopathological effects and toxicities following concurrent chemoradiotherapy were examined. The subjects consisted of 15 patients(10 men and 5 women)who were treated with S-1(60-80mg/day, 4 weeks), superselective intra-arterial infusion of CBDCA(300mg/body)and radiation therapy(total dose 30-36 Gy)in our department ... | 2011 | 22189221 |
| Alleviation of adverse effects of drought stress on growth and some potential physiological attributes in maize (Zea mays L.) by seed electromagnetic treatment. | Effects of varying preseed magnetic treatments on growth, chlorophyll pigments, photosynthesis, water relation attributes, fluorescence and levels of osmoprotectants in maize plants were tested under normal and drought stress conditions. Seeds of two maize cultivars were treated with different (T0 [0 mT], T1 [100 mT for 5 min], T2 [100 mT for 10 min], T3 [150 mT for 5 min] and T4 [150 mT for 10 min]) electromagnetic treatments. Drought stress considerably suppressed growth, chlorophyll a and b p ... | 2011 | 21883242 |
| focus on extralevator perineal dissection in supine position for low rectal cancer has led to better quality of surgery and oncologic outcome. | background: after abdominoperineal excision (ape), the presence of tumor cells in the circumferential resection margin (r1) and iatrogenic tumor perforations are still frequent and result in an increased rate of local recurrences. in this study, a standardized supine ape with an increased focus on the perineal dissection (sppd) is compared to the customary supine ape. methods: from 2000 to 2010, a total of 246 patients underwent ape for rectal cancer (sppd and customary supine ape). all patients ... | 2011 | 21861224 |
| mathematical evaluation of the amino acid and polyphenol content and antioxidant activities of fruits from different apricot cultivars. | functional foods are of interest because of their significant effects on human health, which can be connected with the presence of some biologically important compounds. in this study, we carried out complex analysis of 239 apricot cultivars (prunus armeniaca l.) cultivated in lednice (climatic area t4), south moravia, czech republic. almost all previously published studies have focused only on analysis of certain parameters. however, we focused on detection both primary and secondary metabolite ... | 2011 | 21886093 |
| Clinical and Pathologic Characteristics of Biopsy-Proven Iris Melanoma: A Multicenter International Study. | OBJECTIVE: To collaborate with multiple centers to identify representative epidemiological, clinical, and pathologic characteristics of melanoma of the iris. This international, multicenter, Internet-assisted study in ophthalmic oncology demonstrates the collaboration among eye cancer specialists to stage and describe the clinical and pathologic characteristics of biopsy-proven melanoma of the iris. METHODS: A computer program was created to allow for Internet-assisted multicenter, privacy-prote ... | 2011 | 21911649 |
| kinetic characterization of single strand break ligation in duplex dna by t4 dna ligase. | t4 dna ligase catalyzes phosphodiester bond formation between juxtaposed 5'-phosphate and 3'-hydroxyl termini in duplex dna in three steps: 1) enzyme-adenylylate formation by reaction with atp; 2) adenylyl transfer to a 5'-phosphorylated polynucleotide to generate adenylylated dna; and 3) phosphodiester bond formation with release of amp. this investigation used synthetic, nicked dna substrates possessing either a 5'-phosphate or a 5'-adenylyl phosphate. steady state experiments with a nicked su ... | 2011 | 22027837 |
| recommendations and expert opinion on the treatment of locally advanced rectal cancer in spain. | in spain 22,000 new cases of colorectal cancer are diagnosed each year, with 13,075 deaths resulting from this disease. around 70% of colorectal cancers are localised in the colon and 30% in the rectum. a group of spanish experts established recommendations on what would be the best strategy in the treatment of locally advanced rectal cancer (larc). adequate assessment of local tumour extension, including high-resolution magnetic resonance imaging and endorectal ultrasound, is essential for succ ... | 2011 | 22126729 |
| relationship of obesity, androgen receptor genotypes and biochemical failure after radical prostatectomy. | background: obesity and androgen metabolism have been implicated in the progression of prostate cancer. obesity has been associated with increased risk for advanced disease and biochemical failure after treatment. this association may be the result of changes in androgen metabolism that occur with obesity and are mediated by the androgen receptor (ar). methods: to evaluate the effects of obesity and ar polymorphisms on biochemical failure, we conducted a study of 536 caucasian prostate cancer ca ... | 2011 | 22025404 |
| improved binding free energy predictions from single-reference thermodynamic integration augmented with hamiltonian replica exchange. | reliable predictions of relative binding free energies are essential in drug discovery, where chemists modify promising compounds with the aim of increasing binding affinity. conventional thermodynamic integration (ti) approaches can estimate corresponding changes in binding free energies, but suffer from inadequate sampling due to ruggedness of the molecular energy surfaces. here, we present an improved ti strategy for computing relative binding free energies of congeneric ligands. this strateg ... | 2011 | 22046108 |
| [clinical study of safflower injection in treating and preventing the vascular crisis after free flap transplantation]. | to observe the clinical efficacy of safflower injection (al) in treating and preventing the vascular crisis after free flap transplantation. | 2011 | 22097197 |
| the expression of the hypoxia markers ca9 and cxcr4 is correlated with survival in patients with neuroendocrine tumours of the ileum. | background/aim: the hypoxia-inducible factor pathway regulates the expression of a diverse group of molecules such as ca9 and cxcr4. our aim was to investigate the expression of these markers in a series of patients with an ileal neuroendocrine tumour (iet) at various stages of tumorigenesis. methods: the immunohistochemical expression of ca9 and cxcr4 was examined in 51 patients with a resected iet. a 'hypoxic score' was calculated, integrating the expression of both ca9 and cxcr4 (hypoxic scor ... | 2011 | 22133596 |
| how type of parturition and health status influence hormonal and metabolic profiles in newborn foals. | thyroid hormones, insulin growth factor i (igf-i) and non-esterified fatty acids (nefa) represent important hormonal and metabolic factors associated with perinatal growth and maturation. their action could be influenced by the type of parturition and the health status of the foal and therefore the aim of this work is to evaluate their plasma concentrations in newborn foals during the first 2 wks of life. three groups of subjects were enrolled: 15 healthy foals born by spontaneous parturition, 2 ... | 2011 | 22153270 |
| [the expressions of alpha-enolase in the nasopharyngeal cancer tissue]. | to study the meaning of expressions of eno1 in the nasopharyngeal cancer tissue. | 2011 | 21950004 |
| real-time detection of hepatic micrometastases from pancreatic cancer by intraoperative fluorescence imaging: preliminary results of a prospective study. | background: recently, a highly sensitive fluorescent imaging technique was developed for the real-time identification of hepatic tumors. the authors applied this procedure for the intraoperative detection of radiographically occult hepatic micrometastases from pancreatic cancer. methods: forty-nine consecutive patients with pancreatic cancer who underwent surgical intervention were examined. preoperative clinical images had not revealed any hepatic metastases. on the day before surgery, indocyan ... | 2011 | 21990070 |
| metabonomic phenotyping reveals an embryotoxicity of deca-brominated diphenyl ether in mice. | recent studies have demonstrated that polybrominated diphenyl ethers (pbdes), a group of industrial chemicals, could disrupt thyroid hormone homeostasis and exhibit neurotoxicity, reproductive toxicity, and embryotoxicity. however, clear evidence of embryotoxicity and neurotoxicity of many of these congeners, such as deca-bde, one of the least bioactive congeners of pbdes, is still lacking. in the present study, we investigated deca-bde embryotoxicity by quantitative analysis of two essential th ... | 2011 | 21995789 |
| indications for staging laparoscopy in clinical t4m0 gastric cancer. | this study was undertaken to determine the efficacy of the clinical indications for performing staging laparoscopy for locally advanced gastric cancer to detect peritoneal metastasis or positive cytology findings. | 2011 | 21953130 |
| clinical evaluation of leukocyte filtration as an alternative anti-inflammatory strategy to aprotinin in high-risk patients undergoing coronary revascularization. | purpose: the use of aprotinin in cardiac surgery is associated with overriding safety concerns. therefore, there is increased research on alternatives. this study investigated the relative benefits of strategic leukofiltration on polymer-coated extracorporeal circuits (ecc), aprotinin, and combined therapy in high-risk patients. methods: eight hundred and seventy-five patients (euroscore 6+) undergoing coronary r ... | 2011 | 22068670 |
| previously unknown thyroid dysfunction in patients with acute ischemic stroke. | bengtsson d, brudin l, wanby p, carlsson m. previously unknown thyroid dysfunction in patients with acute ischemic stroke. acta neurol scand: doi: 10.1111/j.1600-0404.2011.01604.x. © 2011 john wiley & sons a/s. objectives - opinions differ regarding the clinical significance of subclinical thyroid disorders. the aim of the present study was to evaluate the prevalence and influence of previously unknown overt or subclinical thyroid dysfunction in patients with acute ischemic stroke and to look f ... | 2011 | 22034899 |
| sex steroid priming for induction of puberty in thalassemia patients with pulsatile reversible hypogonadotrophic hypogonadism. | growth and pubertal disturbances are the most common causes of morbidity, affecting 60-80% β-thalassemia major (β-tm) patients worldwide, due mainly to hypogonadotrophic hypogonadism (hh). we undertook a 6-year prospective study of 55 indian β-tm children with stunted growth and absent or arrested puberty, aged 15-18 years with pulsatile hh, to evaluate the role of low dose sex steroid priming (6-12 months) for physiological induction of puberty. eighty percent responded favorably with increase ... | 2011 | 22074126 |
| highly efficient dna compaction mediated by an in vivo antitumor-active tetrazolato-bridged dinuclear platinum(ii) complex. | we investigated the effects of antitumor-active tetrazolato-bridged dinuclear platinum(ii) complexes [{cis-pt(nh(3))(2)}(2)(μ-oh)(μ-tetrazolato-n(1),n(2))](2+) (1) and [{cis-pt(nh(3))(2)}(2)(μ-oh)(μ-tetrazolato-n(2),n(3))](2+) (2) on the higher-order structure of a large dna molecule (t4 phage dna, 166 kbp) in aqueous solution through single-molecule observation by fluorescence microscopy. complexes 1 and 2 cause irreversible compaction of dna through an intermediate state in which coil and comp ... | 2011 | 22004345 |