Publications

adjuvant therapy for elderly patients with resected gastric adenocarcinoma: population-based practices and treatment effectiveness.	background: a study was undertaken to determine the survival benefit of postoperative chemoradiation therapy for elderly patients with resected gastric adenocarcinoma. methods: the authors identified 1023 individuals aged 65 years and older (median = 76) who underwent gastrectomy for nonmetastatic stage ib-iv gastric adenocarcinoma diagnosed between 2000 and 2002 in the linked surveillance, epidemiology, and end results-medicare database. they examined factors associated with receiving postopera ...	2011	21692071
lysis from without.	in this commentary i consider use of the term "lysis from without" (lo) along with the phenomenon's biological relevance. lo originally described an early bacterial lysis induced by high-multiplicity virion adsorption and that occurs without phage production (here indicated as lo(v)). notably, this is more than just high phage multiplicities of adsorption leading to bacterial killing. the action on bacteria of exogenously supplied phage lysin, too, has been described as a form of lo (here, lo(l) ...	2011	21687534
accuracy of radiological staging in identifying high-risk colon cancer patients suitable for neoadjuvant chemotherapy: a multicentre experience.	aim:ôçé a pilot study was undertaken to determine the accuracy of ct staging in identifying patients with high risk colon cancers who would be considered a candidates for a neoadjuvant therapy trial (foxtrot) and those at low risk (t1/t2) who would be excluded.. method:ôçé participating radiologists from 19 centres attended workshops for standardisation of image interpretation according to previously defined prognostic criteria: good prognosis tumoursd including, t1/t2, intermediate prognosis, t ...	2011	21689323
leptin stimulates hepatic activation of thyroid hormones and promotes early posthatch growth in the chicken.	hepatic iodothyronine deiodinases (ds) are involved in the conversion of thyroid hormones (ths) which interacts with growth hormone (gh) to regulate posthatch growth in the chicken. previous studies suggest that leptin-like immunoreactive substance deposited in the egg may serve as a maternal signal to program posthatch growth. to test the hypothesis that maternal leptin may affect early posthatch growth through modifying hepatic activation of ths, we injected 5.0++g of recombinant murine leptin ...	2011	21679771
the prognostic importance of midline involvement in oral tongue cancer.	objectives: to examine the importance of midline involvement and other clinicopathologic factors in predicting the rate of contralateral lymph node metastasis and survival in oral tongue squamous cell carcinoma. methods: we used surveillance, epidemiology, and end results data to identify a cohort of 5430 patients with laterally rising tumors. clinicopathologic factors examined as potentially predictive of contralateral lymph node metastasis included extension to midline, t classification, anato ...	2011	21701377
[laryngeal cancer treatment outcomes in our department].	laryngeal cancer is one of the most common types of head and neck cancer. numerous studies have reported treatment outcomes, and therapeutic approaches and results are generally well established. however, the widespread use of concurrent chemoradiation therapy(ccrt)has led to differences among hospitals in laryngeal preservation rates in patients with t2 and t3 tumors. ccrt is the mainstay of treatment for laryngeal cancer in our department, given our goals of achieving organ and functional pres ...	2011	21829068
the role of radiotherapy for t4 non-melanoma skin carcinoma.	introduction: to review outcomes of patients treated with radiotherapy (rt) for t4 non-melanoma skin cancer (nmsc). methods: a retrospective chart review was performed of 21 patients who received rt for t4 nmsc from 2004 to 2010. outcomes of treatment efficacy, rt technique and patient morbidity were analysed. twelve patients (57.1%) were treated definitively without prior treatment, five (23.8%) were recurrent lesions and four (19.1%) were treated postoperatively. ten patients (47.6%) had evide ...	2011	21843177
radiolocalization of sentinel lymph nodes in clinically n0 laryngeal and hypopharyngeal cancers.	we sought to analyze the characteristics of radioactive lymph nodes with metastatic disease and to explore methods for the localization of sentinel lymph nodes (slns) with radionuclide in clinically n0 laryngeal and hypopharyngeal cancer.	2011	21675592
expression, characterization, and antimicrobial ability of t4 lysozyme from methylotrophic yeast hansenula polymorpha a16.	lysozyme is an enzyme that is essential for protection against bacterial infections. in this study, a t4 lysozyme gene was cloned into the yeast expression vector ppic9k under the control of the pichia pastoris glyceraldehyde-3-phosphate dehydrogenase promoter (pgap). a hansenula polymorpha-derived ribosomal dna (rdna)-targeting element was inserted into the expression vector and was critical for stable dna integration into the h. polymorpha chromosome. recombinant t4 lysozyme was successfully e ...	2011	21706412
variations of brain activities of acupuncture to te5 of left hand in normal subjects.	this paper presents the evident effects of acupoint stimulation, using eeg (electroencephalogram) measurements. with acupuncture stimulation and the eeg measurement on the same meridian, eeg is able to accurately detect the effects of acupunctural point stimulation on brain waves. in this study, 24 subjects without heart or neural diseases were randomly separated into two groups of 12, named test and control groups. similar procedures are performed; the subjects lay on a bed with eyes closed for ...	2011	21721148
effect of prepartum supplementation of selenium and vitamin e on serum se, igg concentrations and colostrum of heifers and on hematology, passive immunity and se status of their offspring.	forty heifers at the late stage of gestation were randomly assigned into five groups. heifers were balanced for age, weight, and time of calving in each group. four and 2-áweeks before expected time of calving, the heifers were injected with 0-áml (c), 10-áml (t1), 20-áml (t2), 30-áml (t3), and 40-áml (t4) se and ve supplements, respectively. each milliliter of the supplement contained of 0.5-ámg se as sodium selenite and 50-áiu of dl-alpha-tocopheryl acetate. blood samples were collected from t ...	2011	21833648
effects of intravesical onabotulinumtoxina on bladder dysfunction and autonomic dysreflexia after spinal cord injury: role of nerve growth factor.	study type - aetiology (case control) level of evidenceôçâ3c what's known on the subject? and what does the study add? neurogenic detrusor overactivity (ndo) and autonomic dysreflexia (ad) are common outcomes following spinal cord injury (sci). in this study, we showed that onabotulinumtoxina controlled ndo and ad in rats with t4-sci, and also provided a mechanism for the control of as. objective: ôçóôçé to assess the significance of onabotulinumtoxina (onabota) intravesical administration in bl ...	2011	21733076
relative hypoadiponectinemia, insulin resistance, and increased visceral fat in euthyroid prepubertal girls with low-normal serum free thyroxine.	a lower activity of the thyroid axis within the clinical reference range is related to a dysmetabolic phenotype in adult populations. we posited that such an association is already present as early as in prepubertal childhood. serum thyroid stimulating hormone (tsh) and free t4, body fat (bioelectric impedance), insulin resistance (homeostasis model assessment of insulin resistance (homa(ir))), total and high molecular weight (hmw)-adiponectin and serum lipids were assessed in 234 euthyroid prep ...	2011	21738234
genome of low-temperature t4-related bacteriophage vb_ecom-vr7.	the complete genome sequence of the t4-related low-temperature escherichia coli bacteriophage vb_ecom-vr7 was determined. the genome sequence is 169,285┬ábp long, with a g+c content of 40.3%. overall, 95% of the phage genome is coding. it encodes 293 putative protein-encoding open reading frames (orfs) and trna(met). more than half (59%) of the genomic dna lacks significant homology with the dna of t4, but once translated, 72% of the vb_ecom-vr7 genome (211 orfs) encodes protein homologues of t4 ...	2011	21830070
the increased incidence of congenital hypothyroidism: fact or fancy?	objective: the incidence of congenital hypothyroidism (ch) detected by newborn screening in the us has increased significantly since the early 1990s. we defined the characteristics associated with the increased incidence. patients: a cohort of children with ch born during an earlier period of low incidence (1991-94) was compared with a cohort born during a later period when the incidence of ch had doubled (2001-04). measurements: screening was performed with t4 as the primary marker and tsh o ...	2011	21623857
neonatal hypothyroidism caused by maternal nicotine exposure is reversed by higher t3 transfer by milk after nicotine withdraw.	maternal nicotine exposure leads to neonatal hypothyroidism that can be returned to euthyroidism after nicotine withdrawal. here, we examined the transfer of iodine through milk, deiodinase activities (d1 and d2), and serum t3, t4 and tsh in rat offspring after maternal exposure to nicotine. one day after birth, a minipump was implanted to dams releasing nicotine (nic), 6mg/kg/day for 13days or vehicle saline. animals were killed at the day 15 and 21 of lactation. at day 15, nic-treated dams sho ...	2011	21624425
upregulation of mrna myocardium calcium handling in rats submitted to exercise and food restriction.	background: chronic exercise and food restriction (fr) have directionally opposite changes in transcription of molecular structures of calcium handling and thyroid hormone (th) status. objective: evaluate the association of chronic exercise and fr on serum thyroid hormones and gene transcription of molecular structures of intracellular calcium transients and thyroid receptors in myocardium of rats. methods: male wistar kyoto rats, divided into two groups: control (c, n = 7), fr (r50, n = 7), chr ...	2011	21625820
the hox gene network in hepatocellular carcinoma.	liver organogenesis and cancerogenesis share common mechanisms. hox genes control normal development, primary cellular processes and are characterized by a unique genomic network organization. less is known about the involvement of hox genes with liver cancerogenesis. the comparison of the hox gene network expression between nontumorous livers and hepatocellular carcinomas (hccs) highlights significant differences in the locus a hox genes, located on chromosome 7, with a consistent overexpressio ...	2011	21626505
purification of phage display-modified bacteriophage t4 by affinity chromatography.	abstract: background: affinity chromatography is one of the most efficient protein purification strategies. this technique comprises a one-step procedure with a purification level in the order of several thousand-fold, adaptable for various proteins, differentiated in their size, shape, charge, and other properties. the aim of this work was to verify the possibility of applying affinity chromatography in bacteriophage purification, with the perspective of therapeutic purposes. t4 is a large, ico ...	2011	21627821
beta blockers and breast cancer mortality: a population-based study.	purpose preclinical studies have demonstrated that antagonism of β(2)-adrenergic signaling inhibits several pathways necessary for breast tumor progression and metastasis. a series of population-based observational studies were conducted to examine associations between beta blocker use and breast tumor characteristics at diagnosis or breast cancer-specific mortality. patients and methods linked national cancer registry and prescription dispensing data were used to identify women with a diagnosis ...	2011	21632503
structure of the three n-terminal immunoglobulin domains of the highly immunogenic outer capsid protein from a t4-like bacteriophage.	the head of bacteriophage t4 is decorated with 155 copies of the highly antigenic outer capsid protein or hoc. one hoc molecule binds near the center of each hexameric capsomer. hoc is dispensable for capsid assembly and has been used to display pathogenic antigens on the t4 surface. here we report the crystal structure of a protein containing the first three of four domains of hoc from the bacteriophage rb49, a close relative of t4. the structure shows an approximately linear arrangement of the ...	2011	21632759
levothyroxine absorption in morbidly obese patients before and after roux-en-y gastric bypass (rygb) surgery.	background: roux-en-y gastric bypass (rygb) modifies the anatomical structure of the upper intestine tract, reduces gastric acid secretion, and may impair lt4 absorption. the aim of this study was to evaluate the lt4 absorption in morbidly obese patients before and after rygb. methods: thirty morbidly obese patients were divided in two groups: the ns group included 15 patients before rygb surgery (bmi = 43.1 ± 4 kg/m(2)), and the s group included 15 patients after surgery (bmi = 37.3 ± 4 kg/m(2) ...	2011	21633823
sentinel node biopsy should be offered in thin melanoma with mitotic rate greater than one.	background the american joint committee on cancer recently added mitotic rate (mr) to their seventh edition staging system for melanomas, which went into effect on january 1, 2010. mr has replaced the clark level of invasion for t1 melanomas. dermatologists and dermatopathologists should be aware of these new guidelines. objective to clarify how mr may be used to determine the prognosis of thin melanomas and to identify patients with thin melanomas who would be candidates for a sentinel lymph no ...	2011	21635622
alternative promoter usage and differential expression of multiple transcripts of mouse prkar1a gene.	prkar1a gene encodes regulatory type 1 alpha subunit (riα) of camp-dependent protein kinase (pka) in mouse. the role of this gene has been implicated in carney complex and many cancer types that suggest its involvement in physiological processes like cell cycle regulation, growth and/or proliferation. we have identified and sequenced partial cdna clones encoding four alternatively spliced transcripts of mouse prkar1a gene. these transcripts have alternate 5' utr structure which results from spli ...	2011	21638026
increased thyroidal t4 to t3 conversion in autonomously functioning thyroid adenoma: from euthyroidism to thyrotoxicosis.	aim: the aim was to investigate whether the intrathyroid conversion of t4 to t3 in autonomously functioning thyroid adenoma (afta) tissue could influence serum t3 levels and suppression of tsh, especially in patients with borderline thyroid function. patients and methods: in ten patients with afta, thyroidal conversion of t4 to t3 was investigated in nodular and paranodular, tsh-suppressed tissue. all patients had normal serum t4 and suppressed tsh. serum t3 was normal in six, and borderline or ...	2011	21640977
effects of maternal subclinical hypothyroidism on obstetrical outcomes during early pregnancy.	background maternal hypothyroidism (oh and sch) during early pregnancy is suspected to associate with adverse obstetrical outcomes. aim the aim of the present study was to investigate whether maternal subclinical hypothyroidism during the early stage of pregnancy increase obstetrical complications and whether treatment results in an improvement in these outcomes. subjects and methods a total of 756 women in the first trimester (≤12 weeks) of pregnancy were enrolled through ten hospitals in sheny ...	2011	21642766
long-term response in advanced bladder cancer involving the use of temsirolimus and vinflunine after platin resistance.	relapse after initial first-line chemotherapy shows a poor prognosis in metastatic urothelial cancer. currently, several chemotherapeutic agents and targeted drugs are under evaluation for platin-resistant advanced urothelial carcinoma. vinflunine has been approved for second-line treatment in this indication. we present a patient with initial t4 advanced and subsequently metastasized bladder cancer, who has shown prolonged survival of 44 months after radical cystectomy. during her clinical cour ...	2011	21642839
interleukin-1{beta} (il-1{beta}) promotes susceptibility of toll-like receptor 5 (tlr5) deficient mice to colitis.	background the extent to which numerous strains of genetically engineered mice, including mice lacking toll-like receptor 5 (t5ko), display colitis is environment dependent. gut microbiota underlie much of the variation in phenotype. accordingly, embryonic rederivation of t5ko mice ameliorated their spontaneous colitis despite only partially correcting elevated proinflammatory gene expression. it was postulated that endogenous anti-inflammatory pathways mediated the absence of overt inflammation ...	2011	21646247
coordination of dna replication and recombination activities in the maintenance of genome stability.	across the evolutionary spectrum, living organisms depend on high-fidelity dna replication and recombination mechanisms to maintain genome stability and thus to avoid mutation and disease. the repair of severe lesions in the dna such as double-strand breaks or stalled replication forks requires the coordinated activities of both the homologous recombination and dna replication machineries. growing evidence indicates that so-called "accessory proteins" in both systems are essential for the effect ...	2011	21647941
[the effect of sevoflurane inhalation anesthesia only and propofol total intravenous anesthesia on perioperative cytokine balance in lung cancer patients].	to investigate the effects of sevoflurane inhalation anesthesia only and propofol total intravenous anesthesia on perioperative cytokine balance in lung cancer patients.	2011	21651869
could thyroid dysfunction influence outcome in sunitinib-treated metastatic renal cell carcinoma?	background: sunitinib is a standard of care for metastatic renal cell carcinoma (mrcc). hypothyroidism is frequently observed under sunitinib therapy. this study was conducted to prospectively determine the correlation between thyroid function and progression-free survival (pfs) in this population. patients and methods: one hundred and eleven mrcc patients treated with sunitinib were evaluated for serum thyroid-stimulating hormone (tsh) and t4 levels before treatment and every 6 weeks during tre ...	2011	21653681
in ovo thyroxine exposure alters later uvs cone loss in juvenile rainbow trout.	thyroid hormones (ths) play a vital role in vertebrate neural development, and, together with the beta isoform of the thyroid hormone receptor (trβ), the development and differentiation of cone photoreceptors in the vertebrate retina. rainbow trout undergo a natural process of cone cell degeneration during development and this change in photoreceptor distribution is regulated by thyroxine (t4; a thyroid hormone). in an effort to further understand the role of t4 in photoreceptor ontogeny and lat ...	2011	21653819
minimum 5-year radiographic results of long scoliosis fusion in juvenile spinal muscular atrophy patients: major curve progression after instrumented fusion.	previous studies reported on spinal muscular atrophy (sma) scoliosis surgery outcomes without focus on major curve progression (mcp). the purpose of this study was to assess minimum 5-year radiographic outcomes, mcp, and factors for mcp after spinal surgery in juvenile sma patients with open triradiate cartilage at the time of surgery.	2011	21654453
effect of magnesium infusion on thoracic epidural analgesia.	patients of lung volume reduction surgery (lvrs) having an asa status iii or more are likely to be further downgraded by surgery to critical levels of pulmonary function.	2011	21655018
quick and clean cloning: a ligation-independent cloning strategy for selective cloning of specific pcr products from non-specific mixes.	we have developed an efficient strategy for cloning of pcr products that contain an unknown region flanked by a known sequence. as with ligation-independent cloning, the strategy is based on homology between sequences present in both the vector and the insert. however, in contrast to ligation-independent cloning, the cloning vector has homology with only one of the two primers used for amplification of the insert. the other side of the linearized cloning vector has homology with a sequence prese ...	2011	21655102
late onset pott's paraplegia in patients with upper thoracic sharp kyphosis.	purpose: the purpose of this study was to determine the clinical results of patients with late onset upper thoracic sharp pott's kyphosis and to predict the prognosis for pott's paraplegics. method: the study included five patients who developed late onset upper thoracic (t1-t4) sharp pott's kyphosis /kyphoscoliosis within a period from 19 to 37 years after the active disease was healed. the kyphosis angle of the patients ranged from 95° to 105°. among them, three patients suffered onset of para ...	2011	21656306
[hypothyroidism].	hypothyroidism is one of the most frequent endocrine disorders affecting 4.6% of the adult population. 90% of the cases represent subclinical hypothyroidism, defined by increased serum tsh but normal free thyroxine (ft4) values. general screening for hypothyroidism is not recommended because of lack of benefits for the patients. search for hypothyroidism should therefore focus on patients with symptoms and signs and/or those presenting risk factors for development of hypothyroidism (e.g., autoim ...	2011	21656490
detection of 5-hydroxymethylcytosine in dna by transferring a keto-glucose by using t4 phage β-glucosyltransferase.		2011	21656634
multivisceral resection for primary locally advanced rectal carcinoma.	pelvic multivisceral resection offers the possibility of cure in patients with locally advanced rectal cancer. this study assessed the clinical outcome and determinants of survival and local recurrence in patients undergoing multivisceral resection for clinical t4 primary rectal cancer.	2011	21656723
suppression of autophagy and activation of glycogen synthase kinase 3beta facilitate the aggregate formation of tau.	neurofibrillary tangle (nft) is a characteristic hallmark of alzheimer's disease. gsk3╬▓ has been reported to play a major role in the nft formation of tau. dysfunction of autophagy might facilitate the aggregate formation of tau. the present study examined the role of gsk3╬▓-mediated phosphorylation of tau species on their autophagic degradation. we transfected wild type tau (t4), caspase-3-cleaved tau at asp421 (t4c3), or pseudophosphorylated tau at ser396/ser404 (t4-2ec) in the presence of ac ...	2011	21660151
preoperative serum carbohydrate antigen 242 is a useful predictive and prognostic marker in colorectal cancer.	tumor markers (tm) play an important role in the management of colorectal cancer (crc). this study evaluates the predictive and prognostic value of preoperative serum carbohydrate antigen 242 (ca242) in crc.	2011	21661399
long-term survivors of esophageal carcinoma with distant lymph node metastasis.	clinical extra-regional lymph node metastasis, m1 lymph node metastasis (m1 lym), has been recognized as a far advanced condition in esophageal cancer. however, some patients with m1 lym survive long-term. the purpose of this study was to identify the clinicopathological features of those patients with m1 lym achieving long-term survival.	2011	21661407
mortality among men with locally advanced prostate cancer managed with noncurative intent: a nationwide study in pcbase sweden.	there are limited prognostic data for locally advanced prostate cancer pca to guide in the choice of treatment.	2011	21664039
pre-operative bevacizumab, capecitabine, oxaliplatin and radiation among patients with locally advanced or low rectal cancer: a phase ii trial.	background: to evaluate the safety and efficacy of pre-operative chemoradiation, using capecitabine, oxaliplatin and bevacizumab with standard doses of radiation, in patients with high-risk rectal cancer. methods: patients with locally advanced or low rectal cancer were treated with capecitabine 825mg/m(2) twice daily on days 1-14 and 22-35, oxaliplatin 50mg/m(2) on days 1, 8, 22 and 29, bevacizumab 5mg/kg on days 14, 1, 15 and 29, and radiation 50.4gy in 28 fractions including boost. total meso ...	2011	21664123
heterologous expression and purification of membrane-bound pyrophosphatases.	membrane-bound pyrophosphatases (m-ppases) are enzymes that couple the hydrolysis of inorganic pyrophosphate to pumping of protons or sodium ions. in plants and bacteria they are important for relieving stress caused by low energy levels during anoxia, drought, nutrient deficiency, cold and low light intensity. while they are completely absent in mammalians, they are key players in the survival of disease-causing protozoans making these proteins attractive pharmacological targets. in this work, ...	2011	21664973
efficacy of fluoro-2-deoxy-d-glucose positron emission tomography to evaluate responses to concurrent chemoradiotherapy for head and neck squamous cell carcinoma.	this study evaluates the utility of fluorodeoxyglucose-positron emission tomography (fdg-pet) in patients with head and neck squamous cell carcinoma (hnscc) who received concurrent chemoradiotherapy (ccrt).	2011	21665394
acute loading and aging effects on myostatin pathway biomarkers in human skeletal muscle after three sequential bouts of resistance exercise.	to determine the influence of age and resistance exercise on myostatin pathway-related genes, younger (n = 10; 28 -¦ 5 years) and older (n = 10; 68 -¦ 6 years) men underwent four testing conditions (t1-t4). a baseline (t1) muscle sample was obtained, whereas the second and third biopsies were obtained 48 hours following the first and second training sessions (t2, t3), and a final biopsy was taken 24 hours following t3. the training sessions consisted of 3 sets of 10 repetitions (80% of one repet ...	2011	21665986
phosphatase-like activity, dna binding, dna hydrolysis, anticancer and lactate dehydrogenase inhibition activity promoting by a new bis-phenanthroline dicopper(ii) complex.	a new bis-phenanthroline dicopper(ii) complex has been synthesized and characterized by elemental analysis and spectroscopic methods. the molecular structure of the dinuclear cu(ii) complex [cu(2)(╬╝-ch(3)coo)(╬╝-h(2)o)(╬╝-oh)(phen)(2)](2+) (phen = 1,10-phenanthroline) (1) was determined by single crystal x-ray diffraction technique. the coordination environment around each cu(ii) ion in complex 1 can be described as slightly distorted square pyramidal geometry. the distance between the cucu cen ...	2011	21666926
cationic phenylene ethynylene polymers and oligomers exhibit efficient antiviral activity.	the antiviral activities of poly(phenylene ethynylene) (ppe)-based cationic conjugated polyelectrolytes (cpe) and oligo-phenylene ethynylenes (ope) were investigated using two model viruses, the t4 and ms2 bacteriophages. under uv/visible light irradiation, significant antiviral activity was observed for all of the cpes and opes; without irradiation, most of these compounds exhibited high inactivation activity against the ms2 phage and moderate inactivation ability against the t4 phage. transmis ...	2011	21667949
idiopathic primary ovarian insufficiency: a study of serial hormonal profiles to assess ovarian follicular activity.	ovarian follicular activity in serial hormone profiles has been reported in up to 86% of patients with primary ovarian insufficiency (poi). in most of these studies, patients had a short duration of amenorrhea or irregular menstrual cycles which could influence the occurrence of spontaneous follicular activity. the aim was to study the incidence of follicular activity in serial hormonal profiles of women with spontaneous poi and amenorrhea of 1 year duration.	2011	21669968
the ability of phased-array mri in preoperative staging of primary rectal cancer: correlation with histopathological results.	purpose: this study evaluated the accuracy of phased-array mri for preoperative local tumor staging in primary rectal cancer and emphasized the importance of the preoperative differentiation of t2 tumors from t3 tumors so the appropriate treatment can be applied. materials and methods: twenty-four patients with primary rectal cancer were examined preoperatively using 1.5-t magnetic resonance imaging with a phased-array coil. multiplanar t2-weighted images were obtained. rectum anatomy, depth of ...	2011	21671218
vertebral morphometry by x-ray absorptiometry: which reference data for vertebral heights?	the recent improvement in the resolution of dual-energy x-ray absorptiometry (dxa) images enables most vertebral levels to be seen adequately and thus dxa may be a worthwhile alternative to radiologic morphometry for the identification of vertebral fractures (vf). in this multicenter study, we have derived reference data for vertebral heights and their ratios in italian women using morphometric x-ray absorptiometry (mxa).	2011	21672644
[combined transplantation of a free skin island flap supplied by a septo-cutaneous perforator of the posterior tibial artery and the underlying fibula for the full reconstruction of the mandible and the mouth floor].	microsurgical transplantation of the osteo-cutaneous fibula as a free flap to reconstruct the defect following radical resection of a mouth floor's tumor is a well-known and often applied procedure. anatomy of the vessels supplying this flap is recognized but it may have some rare and unexpected variations. in this case report we discuss the reconstruction of the middle and lateral parts of the mandible which was resected due to a t4 gingival tumor. interestingly, the aforementioned segment of t ...	2011	21672684
vertebral body stapling as an alternative in the treatment of idiopathic scoliosis.	unilateral vertebral body stapling as a fusionless alternative to control curvature progression in patients with idiopathic scoliosis (is).	2011	21674182
survival and quality of life following cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis of colonic origin.	background: peritoneal carcinomatosis of colonic origin (pcc) is a life-threatening diagnosis. cytoreductive surgery (cs) with hyperthermic intraperitoneal chemotherapy (hipec) offers patients the prospect of long-term survival with alleviation of symptoms. methods: patients underwent hipec for pcc and completed questionnaires preoperatively (t1) and after surgery at 3 (t2), 6 (t3), and 12 (t4) months. questionnaires included the functional assessment of cancer therapy-colon (fact-c), brief pain ...	2011	21674272
nick sealing by t4 dna ligase on a modified dna template: tethering a functional molecule on d-threoninol.	efficient dna nick sealing catalyzed by t4 dna ligase was carried out on a modified dna template in which an intercalator such as azobenzene had been introduced. the intercalator was attached to a d-threoninol linker inserted into the dna backbone. although the structure of the template at the point of ligation was completely different from that of native dna, two odns could be connected with yields higher than 90 % in most cases. a systematic study of sequence dependence demonstrated that the l ...	2011	21815224
intuitive visualization and quantification of intraventricular convection in acute ischemic left ventricular failure during early diastole using color doppler-based echocardiographic vector flow mapping.	the aim of this study was to make an intuitive visualization of intraventricular convection (ic) and quantification of intraventricular convection velocity (icv) in acute ischemic left ventricular (lv) failure of open-chest canines during early diastole contrast to the baseline conditions using color doppler-based echocardiographic vector flow mapping (vfm). the animal care committee approved this prospective study. in 6 anesthetized open-chest beagle models, the emergence time and the emergence ...	2011	21814809
spinal intramedullary cysticercosis: a case report and literature review.	neurocysticercosis, involvement of the central nervous system by taenia solium, is one of the most common parasitic diseases of the cns. however, spinal involvement by neurocysticercosis is uncommon. here, we reported a 40-year-old woman with intramedullary cysticercosis in the thoracic spinal cord. mri revealed two well-defined round intramedullary lesions at t4 and t5 vertebral levels, which were homogeneously hypointense on t1wi and hyperintense on t2wi with peripheral edema. since the patien ...	2011	21814474
developmental treatment with bisphenol a or ethinyl estradiol causes few alterations on early preweaning measures.	since bisphenol a (bpa) exposure is nearly ubiquitous, increased knowledge of its potential effects on development will enable better risk assessment and regulatory guidance. here, sprague-dawley rats were reared in low exogenous estrogen environments. after breeding at adulthood, dams were gavaged on gestational days (gds) 6-21 with vehicle (veh), 2.5 or 25.0 μg/kg/day bpa, or 5.0 or 10.0 μg/kg/day ethinyl estradiol (ee(2)). offspring were orally treated on pnds 1-21 with the same dose the dam ...	2011	21813462
[intervention of astragalus injection on the kidney injury after cardiopulmonary bypass of infants with congenital heart disease].	to study the intervention of astragalus injection in the kidney injury of infants with congenital heart disease after cardiopulmonary bypass, thus providing a new method for protection of the kidney injury in them.	2011	21812263
challenges in the management of stage ii colon cancer.	approximately one third of patients diagnosed with early-stage colon cancer will present with lymph node involvement (stage iii) and about one quarter with transmural bowel wall invasion but negative lymph nodes (stage ii). adjuvant chemotherapy targets micrometastatic disease to improve disease-free (dfs) and overall survival (os). while beneficial for stage iii patients, the role of adjuvant chemotherapy is unestablished in stage ii disease. this likely relates to the improved outcome of these ...	2011	21810510
[effects of lys-glu-asp-gly and ala-glu-asp-glypeptides on hormonal activity and thyroid morphology in hypophysectomized mature and old birds].	the aim of the paper was to investigate effects of lys-glu-asp-gly and ala-glu-asp-gly peptides which were designed and synthesized on the basis of amino acid study of the hypophyseal anterior and posterior lobe peptides on the thyroid morphology and hormonal activity in mature chicken and old birds. hypophysectomy was established to produce atrophic changes in the thyroid gland and development of secondary hypothyrosis. administration of lys-glu-asp-gly and ala-glu-asp-gly tetrapeptides signifi ...	2011	21809626
transform and relax sampling for highly anisotropic systems: application to protein domain motion and folding.	transform and relax sampling (trs) is proposed as a conformational sampling method to enhance "soft" fluctuation in highly anisotropic systems using molecular dynamics simulation. this method consists of three stages; transform, relax, and sampling. in the transform stage, molecular dynamics simulation is performed with randomly assigned force bias to enhance the fluctuations along relatively soft collective movements, as expected from the linear response theory. after relaxing the heated system ...	2011	21806159
trans-placental transfer of thirteen perfluorinated compounds and relations with fetal thyroid hormones.	while the results of animal studies have shown that perfluorinated compounds (pfcs) can modulate concentrations of thyroid hormones in blood, limited information is available on relationships between concentrations of pfcs in human blood serum and fetal thyroid hormones. the relationship between concentrations of pfcs in blood and fetal thyroid hormone concentrations or birth weight, and ratios of major pfcs between maternal and fetal serum were determined. concentrations of pfcs were measured i ...	2011	21805959
intracellular detection of cytosine incorporation in genomic dna by using 5-ethynyl-2'-deoxycytidine.	5-ethynyl-2'-deoxycytidine triphosphate (edctp) was synthesized as a probe to be used in conjunction with fluorescent labeling to facilitate the analysis of the in vivo dynamics of dna-centered processes (dna replication, repair and cytosine demethylation). kinetic analysis showed that edctp is accepted as a substrate by klenow exo(-) and dna polymerase ß. incorporation of 5-ethynyl-2'-deoxycytidine (edc) into dna by these enzymes is, at most, modestly less efficient than native dc. edc-containi ...	2011	21805552
comparison of two ventilation modes in post-cardiac surgical patients.	the cardiopulmonary bypass (cpb)-associated atelectasis accounted for most of the marked post-cpb increase in shunt and hypoxemia. we hypothesized that pressure-regulated volume-control (prvc) modes having a distinct theoretical advantage over pressure-controlled ventilation (pcv) by providing the target tidal volume at the minimum available pressure may prove advantageous while ventilating these atelactic lungs.	2011	21804799
thyroid function in children with nephrotic syndrome.	this study was done to find out the thyroid function of nephrotic children during nephrosis and to compare any significant changes of thyroid function status during nephrosis and remission. this is an observational study with prospective follow up of study subjects. it was carried out over a period of one year from july'2006 to june'2007 in the department of paediatric nephrology, national institute of kidney diseases & urology (nikdu), dhaka, bangladesh. a total of 85 nephrotic children with in ...	2011	21804503
dissociated time course of recovery between genders after resistance exercise.	flores, df, gentil, p, brown, le, pinto, rs, carregaro, rl, and bottaro, m. dissociated time course of recovery between genders after resistance exercise. j strength cond res 25(x): 000-000, 2011-comparisons between men and women of time course responses of strength, delayed-onset muscle soreness (doms), and muscle swelling after a resistance training session are still controversial. therefore, this study examined gender differences in strength loss, muscle thickness (mt), and doms between young ...	2011	21804429
manserin as a novel histochemical neuroendocrine marker in prostate cancer.	objectives: to investigate the presence of manserin in human prostate cancers and to correlate manserin expression with pathologic outcomes and progression-free survival. methods: eighty-seven patients with recent prostate cancer were classified into 4 groups based on gleason score, and manserin immunohistochemistry was correlated with gleason sum grade. to investigate the validity of manserin as a prognostic factor, the cox proportional hazards regression model was performed on 48 patients in o ...	2011	21803620
cephalometric evaluation in different phases of jasper jumper therapy.	the aim of this study was to evaluate the dentoskeletal and soft-tissue effects of class ii malocclusion treatment with the jasper jumper followed by class ii elastics at the different stages of therapy.	2011	21803237
leptin-programmed rats respond to cold exposure changing hypothalamic leptin receptor and thyroid function differently from cold-exposed controls.	we showed that neonatal leptin treatment programmes for hyperleptinemia and central leptin resistance both at 30days-old and adulthood, while programmes for lower serum t3 at 30days-old, but higher thyroid hormones (th) at adulthood. as in these animals, acute cold at 30days-old normalized leptinemia and restored the expression of hypothalamic leptin receptor (obr), here we evaluate the effect of cold exposure on the thyroid function and obr in adult rats programmed by neonatal hyperleptinemia. ...	2011	21803077
eus and magnetic resonance imaging in the staging of rectal cancer: a prospective and comparative study.	accurate locoregional staging is crucial in rectal cancer for deciding patient management because the administration of neoadjuvant therapy depends on it. eus and magnetic resonance imaging (mri) are used indistinctly in the pretherapeutic workup of rectal cancer.	2011	21802588
boty-like retrotransposons in the filamentous fungus botrytis cinerea contain the additional antisense gene brtn.	long-terminal repeat (ltr) retrotransposons typically contain gag, pol, or gag-pol, and in some case env genes. in this work, we used data mining of the botrytis cinerea genomic sequence and a molecular approach to identify boty-like ltr retrotransposons in b. cinerea containing an antisense gene (brtn) between pol and the 3'-ltr. reverse transcriptase pcr (rt-pcr) revealed that some brtn-like genes could be expressed, at least in b. cinerea t4. we conducted blast comparisons and conserved-domai ...	2011	21802103
zebrafish eleutheroembryos provide a suitable vertebrate model for screening chemicals that impair thyroid hormone synthesis.	thyroxine-immunofluorescence quantitative disruption test (tiqdt) was designed to provide a simple, rapid, alternative bioassay for assessing the potential of chemical pollutants and drugs to disrupt thyroid gland function. this study demonstrated that zebrafish eleutheroembryos provided a suitable vertebrate model, not only for screening the potential thyroid disrupting effect of molecules, but also for estimating the potential hazards associated with exposure to chemicals directly impairing th ...	2011	21800831
molecular detection and comparison of acanthamoeba genotypes in different functions of watersheds in taiwan.	the protistan genus acanthamoeba is a free-living amoeba existing in various environments. within this protistan genus, there are some species recognized as potential human pathogens, which may cause granulomatous amoebic encephalitis, acanthamoeba keratitis and chronic granulomatous lesions of the skin. in this study, 211 water samples were collected from two watersheds in southern taiwan. we detected acanthamoeba based on the pcr amplification with a genus-specific primer pair and investigatio ...	2011	21800062
thyroid gland invasion in laryngopharyngeal squamous cell carcinoma: prevalence, endoscopic and ct predictors.	objectives: the authors studied the prevalence of histological thyroid gland invasion in laryngopharyngeal cancer and the preoperative endoscopic and ct signs predictive of this invasion. patients and methods: retrospective study of patients with laryngopharyngeal squamous cell carcinoma (t3 and t4) treated by total laryngectomy or total laryngopharyngectomy associated with concomitant total thyroidectomy or ipsilateral lobectomy and isthmectomy. results: eighty-seven patients were included. ele ...	2011	21798840
metastatic prostate cancer in ossification of the ligamentum flavum-a case report.	background context: no previous reports have described a metastatic tumor located in the ossification of the ligamentum flavum (olf). purpose: to report an extremely rare case of metastatic tumor located in the olf. study design: case report. methods: we report a case of a 54-year-old man who sustained paraparesis attributable to spinal cord compression because of olf in the thoracic spine. results: the olf at t3/t4 and t5/t6, together with the laminae of t3-t6, was resected. histologically, the ...	2011	21798814
application of endoscopic sonography in preoperative staging of rectal cancer: six-year experience.	objectives- the aim of this study was to evaluate our experience with the application of endoscopic sonography in preoperative staging of rectal cancer. methods- between april 2004 and may 2010, 192 patients with rectal cancer first underwent endoscopic sonography and then underwent surgery at our hospital. none of the patients in this study received neoadjuvant therapy. the endoscopic sonographic staging results were compared with those of postoperative pathologic staging. results- the accuracy ...	2011	21795480
screw motion regulates multiple functions of t4 phage protein gp5 during cell puncturing.	bacteriophage t4 penetrates the outer membrane of escherichia coli using a multifunctional device composed of a gene product 5 (gp5) protein trimer. we report that gp5 sequentially exerts distinct functions along the course of penetration stages induced by screw motion. a triple-stranded ß-helix of gp5 act as a cell-puncturing drill bit to make a hole on the membrane and then send the lipids upwards efficiently by strong charge interactions. the gp5 lysozyme domains, which degrade the peptidogly ...	2011	21793574
relevance of both individual risk factors and occupational exposure in cancer survival studies: the example of intestinal type sinonasal adenocarcinoma.	objectives/hypothesis: wood dust is a well-established risk factor for intestinal type sinonasal adenocarcinoma. the 5-year overall survival has varied from 20% to 80% according t1-t4 stages; 5-year survival according to histologic subtype has varied from 20% to 50%. to date, no study has evaluated whether environmental, occupational, and personal risk factors have any impact on both overall and cancer-specific survival. we aimed to determine whether exposure to carcinogenic risk factors besides ...	2011	21792978
t3+ and t4 rectal cancer patients seem to benefit from the addition of oxaliplatin to the neoadjuvant chemoradiation regimen.	background: to achieve t-downstaging and better resectability in locally advanced rectal cancer, neoadjuvant radiochemotherapy (rct) has become the current standard of treatment. a variety of schemes have been used. this study investigates which scheme had the best effect on these parameters. methods: our institution is a referral center for locally advanced rectal cancer. different neoadjuvant radiochemotherapy regimens were administered: long course radiotherapy (rth), 5-fu and leucovorin (5fu ...	2011	21792506
thyroxine and free thyroxine levels in workers occupationally exposed to inorganic lead.	the effects of lead exposure on thyroid function are unclear.	2011	21792313
adjuvant chemoradiotherapy for locoregionally advanced and high-risk salivary gland malignancies.	abstract: background: to report the outcomes of patients with locoregionally advanced and high- risk salivary gland malignancies treated with surgery followed by adjuvant chemoradiotherapy. methods: from 09/1991 - 06/2007, 24 high-risk salivary gland cancer patients were treated with surgery, followed by adjuvant chemoradiotherapy for high-risk pathologic features including, perineural involvement, nodal involvement, positive margins, or t3/t4 tumors. chemoradiotherapy was delivered for 4-6 alte ...	2011	21791072
effects of dehydroepiandrosterone supplementation during stressful military training: a randomized, controlled, double-blind field study.	dehydroepiandrosterone (dhea) and dhea sulfate (dheas) are anabolic prehormones involved in the synthesis of testosterone. both have been shown to exert neuroprotective effects during stress. in this randomized, controlled, double-blind field study, we examined the effects of a 12-day dhea regimen on stress indices in military men undergoing survival training. forty-eight men were randomized to either a dhea treatment group or placebo control group. the treatment group received 50 mg of oral dhe ...	2011	21790446
catecholamine secreting paraganglioma of the thoracic spinal column: report of an unusual case and review of the literature.	background and importance:: paragangliomas are rare tumors of neuroendocrine origin that arise from paraganglionic tissue of the extrachromaffin cell system. these lesions may be seen at various sites along the neuroaxis. primary thoracic paragangliomas have rarely been in the literature, with secretory thoracic lesions being exceedingly rare as only three previous cases have been cited. clinical presentation:: a 49 year old female presented with episodes of hypertension, palpitations, and diaph ...	2011	21788916
adjuvant chemotherapy for stage ii colon cancer with poor prognostic features.	purpose adjuvant chemotherapy is typically considered for patients with stage ii colon cancer characterized by poor prognostic features, including obstruction, perforation, emergent admission, t4 stage, resection of fewer than 12 lymph nodes, and poor histology. despite frequent use, the survival advantage conferred on patients with stage ii disease by chemotherapy is yet unproven. we sought to determine the overall survival benefit of chemotherapy among patients with stage ii colon cancer havin ...	2011	21788561
feed intake and utilization in sheep fed graded levels of dried moringa (moringa stenopetala) leaf as a supplement to rhodes grass hay.	the effects of feeding graded levels of dried moringa (moringa stenopetala) leaf on intake, body weight gain (bwg), digestibility and nitrogen utilization were studied using male sheep (bw of 13.8?±?0.12 kg). six sheep were randomly allocated to each of the four treatment diets: rhodes grass (chloris gayana) hay offered ad libitum (t1), hay?+?150 g moringa leaf (t2), hay?+?300 g moringa leaf (t3), hay?+?450 g moringa leaf (t4) were offered daily. a 7-day digestibility trial and an 84-day growth ...	2011	21786162
multivisceral resection for gastric cancer: a systematic review.	background: the overall prognosis and survival of patients with advanced gastric cancer is generally poor. one of the most powerful predictors of outcomes in gastric cancer surgery is an r0 resection. however, the extent of the required surgical resection and the additional benefit of multivisceral resection (mvr) are controversial. methods: electronic literature searches were conducted using medline, embase, and the cochrane central register of controlled trials from january 1, 1998 to december ...	2011	21785926
tumor budding and dedifferentiation in gallbladder carcinoma: potential for the prognostic factors in t2 lesions.	dedifferentiation (dd) is often encountered in gallbladder carcinoma (gbc) and poor prognosis with budding (bd) has been reported for other malignancies. however, the features of dd and bd in gbc remain unclear. the purpose of this study was to clarify the features and prognostic potential of dd and bd in gbc. a total of 80 patients with gbc (excluding intramucosal cancer) were enrolled. dd was histopathologically evaluated as tumors in which the grade of the invasive front is higher than the gr ...	2011	21785869
in vitro ultramorphological assessment of apoptosis on cemss induced by linoleic acid-rich fraction from typhonium flagelliforme tuber.	the plant typhonium flagelliforme, commonly known as "rodent tuber" in malaysia, is often used as a health supplement and traditional remedy for alternative cancer therapies, including leukemia. this study aimed to evaluate in vitro anti-leukemic activity of dichloromethane extract/fraction number 7 (dcm/f7) from t. flagelliforme tuber on human t4 lymphoblastoid (cemss) cell line. the dcm extract of tuber has been fractionated by column chromatography. the obtained fractions were evaluated for i ...	2011	21785623
do inertial sensors represent a viable method to reliably measure cervical spine range of motion?	a rise in neck pain cases has initiated an exponential interest in the assessment and treatment of cervical spine range of motion (crom). experimental limitations, however, have been reported as therapists strive to collect continuous, dynamic data to aid prognosis. this technical report seeks to explore the viability of using inertial sensors to reliably assess crom. in recognition of the need for secure skin-sensor attachment, four combinations of sensor pairings were established and investiga ...	2011	21784696
cd11d integrin blockade reduces the systemic inflammatory response syndrome after spinal cord injury.	traumatic injury to the spinal cord triggers a systemic inflammatory response syndrome (sirs), in which inflammatory cells from the circulation invade organs such as the liver, lung and kidney, leading to damage of these organs. our previous study (gris, et al, exp. neurol, 2008) demonstrated that spinal cord injury (sci) activates circulating neutrophils that then invade the lung and kidney from 2 to 24h after injury, increasing myeloperoxidase activity, cyclooxygenase-2 and matrix metalloprote ...	2011	21784069
intensity-modulated radiotherapy (imrt)/tomotherapy following neoadjuvant chemotherapy in stage iib-iva/b undifferentiated nasopharyngeal carcinomas (ucnt): a mono-institutional experience.	to evaluate the outcome of undifferentiated nasopharyngeal carcinomas (ucnt) treated with intensity-modulated radiation therapy with simultaneous integrated boost (sib), following induction chemotherapy. between january 2006 and june 2009, 52 patients with stage ii b-iva/b ucnt were treated either with linac-imrt or tomotherapy. all patients were scheduled to receive three cycles of cisplatin based neoadjuvant chemotherapy. with a median follow-up of 38.5months (range 12.3-64.1), 3year overall s ...	2011	21783403
radical prostatectomy for high-risk prostate cancer defined by preoperative criteria: oncologic follow-up in national multicenter study in 813 patients and assessment of easy-to-use prognostic substratification.	objectives: to estimate the effect of predictive factors for oncologic outcomes after radical prostatectomy (rp) for high-risk prostate cancer (pca). methods: a total of 813 patients underwent rp for high-risk pca in a national retrospective multi-institutional study. high-risk pca was defined as follows: prostate-specific antigen (psa) level >20 ng/ml, gleason score 8-10, and/or clinical stage t2c-t4 disease. the preoperative criteria of high-risk pca were studied in a logistic regression model ...	2011	21783233
a phase ii study of neoadjuvant chemoradiotherapy with oxaliplatin and capecitabine for rectal cancer.	purpose: this study evaluated the efficacy and safety of neoadjuvant chemoradiotherapy with the xelox regimen in rectal cancer patients. patients and methods: twenty-five patients with histopathologically confirmed and locally advanced rectal cancer (t3/t4 or n+) were enrolled in the study. radiotherapy of 5000cgy was delivered in 25 fractions of 200cgy five times per week for a total of 5weeks. during the first, second, fourth and fifth weeks of radiotherapy, the patients also received the foll ...	2011	21782322
[application of free anterolateral thigh flap in head and neck surgery].	to evaluate the results of reconstruction by free anterolateral thigh flaps (alt) after operation of head and neck tumors.	2011	21781558
the association between thyroid hormones and arterial stiffness in peritoneal dialysis patients.	background/aims: the association between thyroid hormones and arterial stiffness is unclear. in this study, we investigated, for the first time in a large cohort of euthyroid peritoneal dialysis patients, the relationship between thyroid hormone levels and arterial stiffness. methods: fifty-seven patients were enrolled. serum tsh, free t3 and free t4 levels were measured by chemiluminescence immunoassay method. pulse wave analysis [augmentation index (aix) and subendocardial viability ratio (sev ...	2011	21779917
erlotinib and chemoradiation in patients with surgically resected locally advanced squamous cell carcinoma of the head and neck: a gicor phase i trial.	background: standard treatment of advanced squamous cell carcinoma of the head and neck (scchn) is concurrent chemoradiation. erlotinib is an oral tyrosine kinase inhibitor of epidermal growth factor receptor, which has shown activity in scchn. phase i study aims to determine the maximum tolerated dose and dose-limiting toxicity (dlt) of adding erlotinib to chemoradiation therapy in patients with surgically resected locally advanced scchn. patients and methods: inclusion criteria-scchn patients ...	2011	21778302
correlation of metabolism/hypoxia markers and fluorodeoxyglucose uptake in oral squamous cell carcinomas.	objective: the objective of this study was to analyze the relationship between the uptake of (18)f-2-fluoro-2-deoxy-d-glucose (fdg) by positron emission tomography-computerized tomography (pet-ct) and glucose metabolism/hypoxia markers in oral squamous cell carcinoma (oscc). study design: thirty-six patients with oscc (tongue [n = 23], buccal mucosa [n = 7], and floor of the mouth [n = 6]) were assessed and underwent incisional biopsy and subsequently received fdg-pet-ct. expressions of hypoxia- ...	2011	21778086
impact of cytoreductive nephrectomy on eligibility for systemic treatment and effects on survival: are surgical complications or disease related factors responsible?	objectives: to understand the impact of cytoreductive nephrectomy on the ability to receive systemic therapy in patients with metastatic renal cell carcinoma. causes of delayed eligibility and effect on overall survival (os) were investigated. methods: patients with metastatic renal cell carcinoma who underwent cytoreductive nephrectomy between 2002 and 2010 were identified. those ineligible to receive systemic therapy >2 months after surgery were considered delayed. reasons for delay and effect ...	2011	21777963