Publications

outcomes of hepatic resection for huge hepatocellular carcinoma (=10?cm in diameter).	the object of the current study was to review the outcomes of hepatic resection for hepatocellular carcinoma (hcc)?=?10?cm.	2011	21465490
carbon ion therapy for advanced sinonasal malignancies: feasibility and acute toxicity.	to evaluate feasibility and toxicity of carbon ion therapy for treatment of sinonasal malignancies. first site of treatment failure in malignant tumours of the paranasal sinuses and nasal cavity is mostly in-field, local control hence calls for dose escalation which has so far been hampered by accompanying acute and late toxicity. raster-scanned carbon ion therapy offers the advantage of sharp dose gradients promising increased dose application without increase of side-effects.	2011	21466696
ischemic post-conditioning attenuates the intestinal injury induced by limb ischemia/reperfusion in rats.	the purpose of this study was to investigate the protective effects of ischemic post-conditioning on damage to the barrier function of the small intestine caused by limb ischemia-reperfusion injury. male wistar rats were randomly divided into 3 groups (n = 36 each): sham operated (group s), lower limb ischemia-reperfusion (group lir), and post-conditioning (group pc). each group was divided into subgroups (n = 6) according to reperfusion time: immediate (0 h; t1), 1 h (t2), 3 h (t3), 6 h (t4), 1 ...	2011	21468513
novel mutation in mct8 gene in a brazilian boy with thyroid hormone resistance and severe neurologic abnormalities.	mct8 is a cellular transporter of thyroid hormones important in their action and metabolization. we report a male patient with the novel inactivating mutation 630insg in the coding region in exon 1 of mct8. he was characterized clinically by severe neurologic impairment (initially with global hypotonia, later evolving with generalized hypertonia), normal growth during infancy, reduced weight gain, and absence of typical signs and symptoms of hypothyroidism, while the laboratory evaluation disclo ...	2011	21468521
effect of zinc and iron fortification of the feed on liver and thyroid function in rats.	changes in plasma glutamate oxaloacetate transaminase (got), glutamate pyruvate transaminase (gpt), triiodothyronine (t3), and thyroxin (t4) of male rats, following 8 weeks of administration of different concentrations of elemental iron (ei), sodium iron ethylenediaminetetraacetate (nafeedta), zinc sulfate (znso(4)), and zinc oxide (zno) in whole wheat flour were investigated. liver enzymes and thyroid hormones were determined using colorimetric methods and enzyme immune assay, respectively. ing ...	2011	21468629
sagittal balance of thoracic lordoscoliosis: anterior dual rod instrumentation versus posterior pedicle screw fixation.	posterior pedicle screw fixation is now the standard treatment for surgical correction of idiopathic scoliosis and has largely replaced anterior techniques, but there have been reports describing a lordogenic effect of segmental pedicle screw instrumentation in the thoracic spine. this clinical study compared anterior dual rod instrumentation with posterior pedicle screw fixation for idiopathic thoracic lordoscoliosis, including 42 patients (7 male, 35 female; average age 16 years, range 12-34) ...	2011	21468646
specialization versus adaptation: two strategies employed by cyanophages to enhance their translation efficiencies.	effective translation of the viral genome during the infection cycle most likely enhances its fitness. in this study, we reveal two different strategies employed by cyanophages, viruses infecting cyanobacteria, to enhance their translation efficiency. cyanophages of the t7-like podoviridae family adjust their gc content and codon usage to those of their hosts. in contrast, cyanophages of the t4-like myoviridae family maintain genomes with low gc content, thus sometimes differing from that of the ...	2011	21470965
maternal thyroid function during pregnancy and behavioral problems in the offspring: the generation r study.	maternal thyroid function during pregnancy is implicated in the neurodevelopment of the offspring, yet little is known about the effect of maternal thyroid parameters on the behavior of children. we investigated the association of maternal thyroid function during the first half of pregnancy with parent-reported problem behavior of the offspring up to age of 3 y. in the generation r study, a population-based cohort of 3736 children and their mothers, data on maternal thyroid function and child's ...	2011	21471776
colorectal cancer and 18fdg-pet/ct: what about adding the t to the n parameter in loco-regional staging?	to evaluate whether fdg-positron emission tomography (pet)/computed tomography (ct) may be an accurate technique in the assessment of the t stage in patients with colorectal cancer.	2011	21472100
dna ligases.	the dna ligase enzyme family catalyzes the formation of a phosphodiester bond between juxtaposed 5'-phosphate and 3'-hydroxyl termini in duplex dna. this activity can seal nicks in duplex dna or join double-stranded dna fragments having either blunt or cohesive ends. dna ligases are central enzymes in molecular biology, nucleic acid research, and in next-generation sequencing applications. reaction conditions and applications for t4 dna ligase, e. coli dna ligase, and thermostable dna ligases ar ...	2011	21472697
surgical outcomes and survival after extended multiorgan resection for t4 gastric cancer.	background: extended multiorgan resection (emr) for locally advanced (t4) gastric cancer remains controversial. the aim of this study was to evaluate the effectiveness of this approach with regard to morbidity, mortality, and survival. methods: between 2005 and 2009, 41 patients underwent aggressive surgery for clinical t4 gastric cancer. univariate and multivariate analyses were used to identify prognostic factors for surgical outcomes and survival in these patients. results: curative resection ...	2011	21474116
identification of interleukin 2, 6, and 8 levels around miniscrews during orthodontic tooth movement.	the aim of this study was to identify the levels of interleukin (il)-2, il-6, and il-8 around miniscrews used for anchorage during canine distalization. sixteen patients (eight males and eight females; mean age, 16.6 ± 2.4 years) who were treated with bilateral upper first premolar extractions were included in the study. thirty-two maxillary miniscrew implants were placed bilaterally in the alveolar bone between the maxillary second premolars and first molars as anchorage units for maxillary can ...	2011	21474566
[effect of adipose differentiation-related protein on the apoptosis of h9c2 cells by palmitic acid.]	aim: to construct a eukaryotic expression vector for expressing adipose differentiation-related protein(adrp) protein and obtain a stable transfected h9c2 cell line. methods: (1)the full length dna fragment of adrp gene was amplified by pcr from the myocardium of adult sd rats and was inserted into pegfp-c1 with t4 ligase. after the identification of digestion and sequencing on the recombinant pegfp-c1-adrp, the recombinant was transformed into e.coli strain dh5α.and the positive recombinant pla ...	2011	21481311
phage t4-induced dttp accretion bolsters a trnase-based host defense.	the anticodon nuclease (acnase) prrc is silenced in escherichia coli by an associated dna restriction-modification protein, activated by the phage t4-encoded anti-dna restriction factor stp and counteracted by t4's trna repair enzymes polynucleotide kinase and rna ligase 1. hence, only trna repair-deficient phages succumb to prrc's restriction. prrc's abc-atpase motor domains are implicated in driving its activation by hydrolyzing gtp and in stabilizing the activated acnase by avidly binding dtt ...	2011	21481433
effects of sulphur and thiobacillusthioparus on cow manure aerobic composting.	a simulated aerobic composting experiment was used to explore the effects of sulphur and thiobacillusthioparus during six manure composting treatments. the addition of sulphur led to a decrease of the ph level within the range 6-6.3, which was lower than the control treatment (ck). the concentration of ammonium nitrogen in t1 (0.25% sulphur), t2 (0.5% sulphur), t3 (0.25% sulphur+t. thioparus) and t4 (0.5% sulphur+t. thioparus) were much higher than the ammonium n in ck. the results indicated tha ...	2011	21482106
inhibition of tumor angiogenesis in lung cancer by t4 phage surface displaying mvegfr2 vaccine.	vascular endothelial growth factor (vegf) has been known as a potential vasculogenic and angiogenic factor and its receptor (vegfr2) is a major receptor to response to the angiogenic activity of vegf. the technique that to break the immune tolerance of "self-antigens" associated with angiogenesis is an attractive approach for cancer therapy with t4 phage display system. in this experiment, mouse vegfr2 was constructed on t4 phage nanometer-particle surface as a recombinant vaccine. t4-mvegfr2 re ...	2011	21482223
peri-implant tissue response following connective tissue and bone grafting in conjunction with immediate single-tooth replacement in the esthetic zone: a case series.	purpose: this case series evaluated the peri-implant tissue response following extraction and immediate placement and restoration of an implant in conjunction with subepithelial connective tissue grafting (sctg) and bone grafting in the esthetic zone. implant success rates and the peri-implant tissue response were also reported. methods and materials: ten patients (four men, six women) with a mean age of 48 years (range, 35 to 70) underwent extraction and immediate tooth replacement with sctg an ...	2011	21483896
[correlation between serum thyroid hormone and dopamine levels and chinese medicine syndrome types].	to analyze the correlation between changes of thyroid hormone (th), dopamine (da) and chinese medicine syndrome types by detecting contents of serum th and da in insomnia, thus to explore objective indices of chinese medicine syndrome types.	2011	21485074
evaluation of physical properties of enamel after microabrasion, polishing, and storage in artificial saliva.	this study evaluated the effect of microabrasion and polishing on the microhardness and roughness of bovine enamel, and the effect of artificial saliva on the hardness of enamel. bovine enamel blocks were used, forming the groups (n = 48): gi-37% phosphoric acid and pumice, gii--opalustre, and giii--whiteness rm. the groups were divided into different subgroups: (a) diamond paste, (b) fluoride prophylactic paste, and (c) without polishing. hardness tests were carried out at the following set tim ...	2011	21487176
no causal relationship between yersinia enterocolitica infection and autoimmune thyroid disease: evidence from a prospective study.	the objective of this study was to evaluate prospectively the relationship between yersinia enterocolitica (ye) infection and the development of overt autoimmune hypo- or hyperthyroidism (study a) and the de novo occurrence of thyroid antibodies (study b). this was a prospective cohort study of 790 euthyroid women who were first- or second-degree relatives of autoimmune thyroid disease (aitd) patients. follow-up was 5 years, with annual assessments. study a was a nested case-control study in whi ...	2011	21488870
increased expression of transcription factor tfap2α correlates with chemosensitivity in advanced bladder cancer.	abstract:	2011	21489314
revisiting low-dose total skin electron beam therapy in mycosis fungoides.	purpose: total skin electron beam therapy (tsebt) is a highly effective treatment for mycosis fungoides (mf). the standard course consists of 30 to 36 gy delivered over an 8- to 10-week period. this regimen is time intensive and associated with significant treatment-related toxicities including erythema, desquamation, anhydrosis, alopecia, and xerosis. the aim of this study was to identify a lower dose alternative while retaining a favorable efficacy profile. methods and materials: one hundred t ...	2011	21489711
s-ketamine modulates hyperalgesia in patients with chronic pancreatitis pain.	upper abdominal pain is a dominant feature of chronic pancreatitis. a key phenomenon in this context is hyperalgesia, typically associated with n-methyl-d-aspartate receptor activation. this exploratory study evaluates acute effects of s-ketamine, a noncompetitive n-methyl-d-aspartate antagonist, in modulating generalized hyperalgesia in chronic pancreatitis pain.	2011	21490522
the effect of milrinone on the intraoperative hemodynamics during off-pump coronary bypass surgery in patients with an elevated echocardiographic index of the ventricular filling pressure.	hemodynamic derangement during off-pump coronary artery bypass surgery (opcab) is mainly attributed to impaired filling and diastolic dysfunction. an elevated ratio of the mitral velocity to the early-diastolic velocity of the mitral annulus (e/e' > 15) is a relatively new indicator of diastolic function, and this was reported to be associated with impaired hemodynamics during opcab. we investigated the efficacy of milrinone on the perioperative hemodynamics and short term outcomes of patients w ...	2011	21490820
[relationship between pd-1 expression on peripheral t lymphcytes and hbeag seroconversion after entecavir treatment in chronic hepatitis b patients.]	to observe longitudinally the expression of programmed death 1(pd-1) on peripheral blood t cells in chronic hepatitis b patients underwent antiviral treatment with entecavir (etv) and to explore the relationship between pd-1 expression and hbeag seroconversion. twenty hbeag positive patients underwent antiviral treatment with etv were followed up for 51 weeks. 14 patients remained hbeag positive and 6 patients achieved hbeag seroconversion. peripheral blood was collected at six time points: t0: ...	2011	21492509
oncologic outcomes after supracricoid partial laryngectomy.	objective. to review the oncologic outcomes of a series of supracricoid partial laryngectomy. design. case series with chart review. setting. la paz university hospital, madrid, spain. patients. forty-one patients with glottic or supraglottic squamous cell carcinoma who underwent supracricoid partial laryngectomy between 1998 and 2008 at the authors' institution. main outcome measure. local control rate, specific-disease survival rate, and overall survival rate. results. all patients were male, ...	2011	21493316
salvage laryngectomy after primary radiotherapy: what are prognostic factors for the development of pharyngocutaneous fistulae?	in this evidence based case report we addressed the clinical question: which factors predict the occurrence of a pharyngocutaneous fistula after total laryngectomy in patients that already were treated with radiotherapy for a squamous cell carcinoma of the larynx? we searched for relevant synonyms for the domain, being patients earlier treated with radiotherapy for a squamous cell carcinoma of the larynx and having a recurrence for which a salvage total laryngectomy is necessary, with the outcom ...	2011	21493379
disruptive effects of persistent organohalogen contaminants on thyroid function in white whales (delphinapterus leucas) from svalbard.	we analysed levels of 56 organohalogen contaminants (ohcs) including brominated flame retardants, polychlorinated biphenyls (pcbs), and organochlorine pesticides in the blubber of white (beluga) whales (delphinapterus leucas) from svalbard, norway (n=12; 6 adults [5 males and 1 female] and 6 subadults [4 males and 2 females]) collected in 1996-2001. we also measured circulating levels of thyroid hormones (ths) and thyroid stimulating hormone (tsh) in the whales. the results confirm that ohc leve ...	2011	21497377
salivary zinc finger protein 510 peptide as a novel biomarker for detection of oral squamous cell carcinoma in early stages.	oral squamous cell carcinoma (oscc) is one of the most frequent malignancies worldwide. early diagnosis can mean adequate treatment and increase survival.	2011	21497587
the new tumor, node, and metastasis staging system.	the seventh edition of the tumor, node, and metastasis (tnm) classification is based on the proposals of the staging project of the international association for the study of lung cancer (iaslc). the analyses of the iaslc international database of 81,015 patients diagnosed with lung cancer between 1990 and 2000 were used to validate the tnm descriptors. the changes include: the subclassification of t1 and t2 tumors into t1a (≤ 2 cm) and t1b (>2 and ≤ 3 cm), and t2a (>3 and ≤ 5 cm) and t2b (>5 an ...	2011	21500123
[effectiveness of transarticular approach in treating thoracic spinal stenosis of calcified ligament].	to investigate the effectiveness of transarticular approach in treating thoracic spinal stenosis due to ossification of ligamentum flavum (olf) and ossification of posterior longitudinal ligament (opll) at the same level.	2011	21500584
thermostabilisation of an agonist-bound conformation of the human adenosine a(2a) receptor.	the adenosine a(2a) receptor (a(2a)r) is a g-protein-coupled receptor that plays a key role in transmembrane signalling mediated by the agonist adenosine. the structure of a(2a)r was determined recently in an antagonist-bound conformation, which was facilitated by the t4 lysozyme fusion in cytoplasmic loop 3 and the considerable stabilisation conferred on the receptor by the bound inverse agonist zm241385. unfortunately, the natural agonist adenosine does not sufficiently stabilise the receptor ...	2011	21501622
do children and adolescents with type 1 diabetes mellitus have a higher frequency of parietal cell antibodies than healthy controls?	parietal cell antibodies (pca) are markers of autoimmune gastritis (ag). ag can lead to hypergastrinemia and iron-deficiency anaemia (ida). compared to healthy controls, adults with type 1 diabetes mellitus (t1dm) show a higher prevalence of pca (1% vs 20%). the aim of the present study was to evaluate the frequency of pca in children and adolescents with t1dm compared to healthy controls and the clinical and biochemical markers.	2011	21502826
evaluation of the effect of l: -thyroxin therapy on endothelial functions in patients with subclinical hypothyroidism.	subclinical hypothyroidism (sh) is characterized by normal serum free t4 (ft4), free t3 (ft3) levels and increased serum thyroid-stimulating hormone (tsh) levels. endothelial dysfunction, which is an early step of atherosclerosis, has been reported in patients with subclinical hypothyroidism. the aim of this study is to evaluate endothelial functions and the effect of l: -thyroxin (l-t4) therapy on endothelial functions in sh. twenty-seven patients with sh and 22 healthy controls were evaluated ...	2011	21505892
t4-like genome organization of the escherichia coli o157:h7 lytic phage ar1.	we report the genome organization and analysis of the first completely sequenced t4-like phage ar1 of e. coli o157:h7. unlike most of the other sequenced phages of o157:h7 strain that belong to the temperate podoviridae and siphoviridae families, ar1 is a t4-like phage known to efficiently infect this pathogenic bacterial strain. the 167,435-bp ar1 genome is currently the largest among all the sequenced e. coli o157:h7 phages. it encodes a total of 281 potential orfs and ten putative trna genes. ...	2011	21507986
variation of the position of the aorta relative to a kyphotic thoracic spine: safety margin for pedicle screw placement in the adult japanese population.	abstract: study design: an analysis of computed tomography images of the spine in adult japanese patients.objective: to evaluate the variation of the position of the aorta relative to a spine with a thoracic kyphotic angle and to verify the safety margin for transpedicular screw fixation.summary of background data: recent studies have suggested that the aorta is positioned more laterally and posteriorly in patients with idiopathic scoliosis than in normal patients; however, variation of the posi ...	2011	21508888
nociceptive inputs transmission in huntington's disease: a study by laser evoked potentials.	the aim of the present study was to evaluate pain perception and evoked responses by laser stimuli (leps) in mild not demented huntington's disease (hd) patients. twenty-eight hd patients and 30 control subjects were selected. leps were obtained by four scalp electrodes, (fz, cz, referred to the nasion; t3, t4, referred to fz), stimulating the dorsum of both hands. all patients were also evaluated by somatosensory evoked potentials (seps) by median nerve stimulation. only 3 patients referred pai ...	2011	21510231
the effects of bromazepam over the temporo-parietal areas during the performance of a visuomotor task: a qeeg study.	this study investigated the effects of bromazepam on qeeg when 14 healthy subjects were asked to perform a visuomotor task (i.e., motor vehicle driving task). the subjects were exposed to two experimental conditions: the placebo (pl) and 6mg of bromazepam (br 6mg), following a randomized, double-blind design on different days. specifically, we observe absolute power extracted from qeeg data for theta band. we expected to see a decrease in absolute theta power in the temporal and parietal areas d ...	2011	21511002
mct8: from gene to disease and therapeutic approach.	thyroid hormone metabolism and action are largely intracellular processes that require transport of the hormone across the plasma membrane by different transporters. two of these, mct8 and mct10, are close members of the monocarboxylate transporter family. mct8 is expressed in a variety of tissues, including liver, kidney, thyroid and brain. the mct8 gene is located on the x chromosome, and mutations in mct8 result in severe psychomotor retardation and low serum t4 and high t3 levels in affected ...	2011	21511238
development of hepatocellular carcinomas in patients with absence of tumors on a prior ultrasound examination.	background: to evaluate hepatocellular carcinoma (hcc) that developed in patients with no evidence of a tumor during a prior ultrasound (us) performed within 1 year of the diagnosis. methods: we retrospectively analyzed data for 100 consecutive patients with liver cirrhosis who had undergone us within 1 year prior to hcc diagnosis and who showed no liver lesions on the previous us. size and t stage of hcc were assessed as well as whether patients met surgical criteria for liver transplantation a ...	2011	21514759
effect of a combined iodine and selenium supplementation on i and se status of cows and their calves.	iodine (i) and selenium (se) deficiencies are commonly reported in cattle, however, there are also studies regarding a very high iodine supply. the aim of the study was to determine the long-term effect of i and se supplementation on non-pregnant cows, pregnant cows and their calves. the hypothalamus pituitary axis was investigated (tsh, t4, t3 assays) during a trh challenge on non-pregnant cows. twenty-four cows, half of them pregnant, were assigned into 2 diet-groups, one group with a low i (0 ...	2011	21514807
[clinical analysis of malignant submandibular tumor].	the 14 cases of malignant submandibular tumor whose treatment outcome we analyzed between 1989 and 2008 included 5 of adenoid cystic carcinoma, 3 of squamous cell carcinoma, 2 each of mucoepidermoid carcinoma, and carcinoma ex pleomorphic adenoma, and 1 each of carcinosarcoma and large-cell carcinoma. one subject was diagnosed with t1, 7 with t2, 4 with t3, and 2 with t4. lymph node involvement occurred in 5, -1 with n1 and 4 with n2. none had distant metastasis on the first visit. seven were tr ...	2011	21516710
in vitro fluorescence displacement investigation of thyroxine transport disruption by bisphenol a.	bisphenol a (bpa) is a chemical with high production volume and wide applications in many industries. although bpa is known as an endocrine disruptor, its toxic mechanisms have not been fully characterized. due to its structural similarity to thyroid hormones thyroxine (t4) and triiodothyronine (t3), one possible mechanism of bpa toxicity is disruption of hormone transport by competitive binding with the transport proteins. in this study, the binding interactions of bpa, t4, and t3 with three th ...	2011	21517007
neoadjuvant chemotherapy for locally advanced breast cancer in a malaysian tertiary hospital.	introduction: neoadjuvant chemotherapy for locally advanced breast cancer is given with the aim of shrinking the disease sufficiently for surgery. however, many clinical trials investigating neoadjuvant chemotherapy regimens were conducted for operable breast cancer. methods and materials: patients with t3-4, n2 m0 breast cancer diagnosed between january 2005 and december 2008 and who received at least one cycle of neoadjuvant chemotherapy were eligible for this study. thirty-four patients were ...	2011	21517250
a case of tsh-producing adenoma treated with octreotide in combination with thiamazole for the control of tsh and thyroid hormones after trans-sphenoidal neurosurgery.	while tsh-producing adenoma (tshoma) is rare, the diagnosis is often delayed because the clinical features are heterogeneous. the patient was a 69-year-old woman who had been referred to the yachiyo medical center in august 2008, because of dyspnea, loss of appetite, weight loss of 10 kg, and diarrhea that lasted 4 years. we diagnosed this patient with pituitary tsh-producing macroadenoma. thyroid hormone concentration was increasing although the serum tsh level was within a normal range after t ...	2011	21519153
full-dose capecitabine with local radiotherapy: one of the treatment options for inoperable t4 breast cancer.	a 48-year-old woman presented with a 15-cm diameter tumor in her left breast with fixation to the chest wall and palpable axillary lymph nodes. pathology study showed pure-type mucinous carcinoma. pretreatment staging investigations showed multiple lung metastases, which resulted in the diagnosis of t4n2m1 breast cancer. four cycles of cyclophosphamide 700 mg/m(2)/epirubicin 70 mg/m(2) (ce) were performed initially, but the tumors decreased only within the treatment response criteria of stable d ...	2011	21519998
[effective reversal of muscle relaxation by rocuronium using sugammadex in a patient with myasthenia gravis undergoing laparoscopic cholecystectomy].	as myasthenia gravis affects neuromuscular transmission, these patients show various responses to neuromuscular blocking drugs. we report a successful use of the sugammadex in a myasthenic patient to reverse rocuronium-induced neuromuscular block. a 69-year-old woman was scheduled for laparoscopic cholecystectomy and total of rocuronium 20 mg was administered. after spontaneous recovery of t1, we administered sugammadex 200mg intravenously, reversing neuromuscular blockade to a train-of-four rat ...	2011	21520600
[bladder preservation using chemoradiation therapy for locally invasive bladder cancer].	we investigated the long-term results and molecular markers of outcome with selective organ preservation in invasive bladder cancer using chemoradiation therapy.	2011	21520632
diagnosis and treatment of hypothyroidism in tsh deficiency compared to primary thyroid disease: pituitary patients are at risk of under-replacement with levothyroxine.	objective achieving optimal thyroid hormone replacement is more difficult in tsh deficiency compared to primary hypothyroidism because of the inability to be guided by serum tsh levels. a combination of clinical symptoms and free thyroxine levels (ft4) are typically used to make a diagnosis and monitor replacement. we investigated the diagnosis of tsh deficiency in patients with pituitary disease and the adequacy of levothyroxine replacement compared with primary thyroid disease. design using ...	2011	21521256
association of thyroid autoimmunity with acne in adult women.	background during the last decades an increase has been observed regarding acne in adults and especially women. objective to evaluate the association between thyroid disorder and the presence of post-adolescent acne in adult women, comparing with healthy controls. methods 107 adult women with post-adolescent acne and 60 healthy controls were included. complete blood count and standard biochemical profile of c-reactive protein (crp) and levels of thyroid hormones and antibodies [triiodothyroni ...	2011	21521376
hair regrowth with topical triiodothyronine ointment in patients with alopecia areata: a double-blind, randomized pilot clinical trial of efficacy.	background thyroid hormone receptors are expressed in hair follicles and it is known that thyroid hormones can have a positive effect on hair growth, i.e. process which is disrupted in alopecia areata. objectives the aim of this study was to determine the efficacy of topical triiodothyronine in patients with patchy alopecia areata. methods ten patients with patchy alopecia areata were treated with triiodothyronine and placebo applied twice daily to either of two bilaterally symmetrical patche ...	2011	21521379
inability of rhtsh to predict the evolution from subclinical hypothyroidism to overt disease. a pilot study.	background: the use of recombinant human tsh is indicated to evaluate thyroid carcinoma patients. in recent years, some authors have reported that rhtsh could serve as a dynamic test of thyroid reserve. the aim of the present study was to determine whether or not rhtsh can predict the evolution from subclinical hypothyroidism (sh) to overt hypothyroidism. materials and methods: twenty-one women who met the diagnostic criteria of sh were enrolled. all patients received a single dose of rhtsh (0.1 ...	2011	21521938
the influence of prognostic factors and adjuvant chemoradiation on survival after pancreaticoduodenectomy for ampullary carcinoma.	introduction: the prognosis after pancreaticoduodenectomy (pd) for ampullary carcinoma (ac) is superior to that of pancreatic cancer. decisions regarding adjuvant therapy are influenced by factors such as nodal status, stage, and grade, but the influence of these individual variables on survival is unclear. methods: a prospective tumor registry database was queried to identify patients who underwent pd for ac at thomas jefferson university between jan 1997 and apr 2009. the study was conducted w ...	2011	21523621
patterns of extralaryngeal spread of laryngeal cancer: thyroid cartilage penetration occurs in a minority of patients with extralaryngeal spread of laryngeal squamous cell cancers.	background: laryngeal preservation programs for patients with advanced laryngeal squamous cell carcinomas (scc) have generally excluded patients with t4 disease. the accuracy of preoperative imaging in evaluating thyroid cartilage penetration and extralaryngeal spread (els) has previously been questioned. clinically, scc spread into noncartilaginous structures may have less of a functional impact when compared with thyroid cartilage penetration. the current study was designed to characterize and ...	2011	21523761
expression and function role of dna methyltransferase 1 in human bladder cancer.	background: the identification of potential tumor markers will help improve therapeutic planning and patient management. therefore, the aim of this study was to highlight the role of dna methyltransferase 1 (dnmt1) in bladder cancer. methods: a total of 50 samples of nonmalignant urothelium, 65 of muscle-invasive bladder cancers, 15 of distant metastasis, and 50 of nonmuscle-invasive bladder cancers were selected for immunohistochemical staining analysis. furthermore, human bladder cancer cell l ...	2011	21523767
ultrasensitive microarray detection of short rna sequences with enzymatically modified nanoparticles and surface plasmon resonance imaging measurements.	a novel multiplexed method for short rna detection that employs an enzymatic capture reaction onto dna-modified silica nanoparticles (sinps) followed by nanoparticle-enhanced surface plasmon resonance imaging (spri) is demonstrated. sinps functionalized with 5'-phosphorylated single stranded dna (ssdna) are used with t4 rna ligase to capture various short 20-24 base single-stranded rna (ssrna) oligonucleotides from a target solution. the ssrna-modified sinps are collected from the target solutio ...	2011	21524060
metabolism and gastric remnant changes after roux-en-y gastric bypass in rats.	abstract background: the roux-en-y gastric bypass (rygb) may affect metabolism, microbiology, and histology of gastric remnant. therefore, this study aimed to investigate these issues in rats. methods: twelve rats were randomly allocated to a rygb group (n = 6) and nonoperated normal rats group (n = 6). after 30 postoperative days, all rats were injected with 0.1ml of na(99m)tc(-) i.v. (radioactivity 0.66 mbq). after 30 min, liver, stomach, thyroid, heart, lung, kidney, and femur samples were ha ...	2011	21524176
sequence characteristics of t4-like bacteriophage ime08 benome termini revealed by high throughput sequencing.	abstract:	2011	21524290
massive levothyroxine ingestion in a pediatric patient: case report and discussion.	abstractwe describe the course of a toddler who ingested a massive amount of levothyroxine and review treatment options for such overdoses. a 2½-year-old boy presented shortly after an ingestion of up to 7.6 mg of levothyroxine (potentially as much as 700 μg/kg). he was initially asymptomatic, treated with oral charcoal 1 g/kg, and discharged home from the emergency department after a few hours. he returned approximately 24 hours later with a temperature of 38.5°c, heart rate of 163 beats per mi ...	2011	21524373
correlation between fas and fasl proteins expression in normal gastric mucosa and gastric cancer.	the study's objective was to assess the expressions of fas and fasl proteins in gastric cancer in correlation with chosen clinicohistological parameters. fas and fasl expression was analyzed in 68 patients with gastric cancer, using the immunohistochemical method. the expression of fas was found to be lower in gastric cancer cells than in healthy mucosa, both in the lining epithelium and in glandular tubes (28% vs. 48% and 44%; p 〈 0.001). the expression of fasl was also markedly lower in cancer ...	2011	21526501
thyroid autoimmunity role in the evolution of endemic goiter in rural area, fars, iran.	who reports indicate no iodine insufficiency in iran, however, goiter is still endemic in fars province. this study evaluates the role of thyroid autoimmunity in the evolution of endemic goiter.	2011	21529102
treatment of a malignant peripheral nerve sheath tumor and its complications through a multidisciplinary approach.	the authors report the case of a 14-year-old girl with a residual malignant peripheral nerve sheath tumor after thoracotomy, chemotherapy, and radiation therapy. the residual tumor, which involved the intercostal muscles, aorta, and neural foramina of t4-10, was completely resected through a costotransversectomy and multiple hemilaminotomies with the patient in the prone position and was stabilized using a t1-12 pedicle screw fusion. postoperatively, the patient developed several infections requ ...	2011	21529197
titanium plates and dualmesh: a modern combination for reconstructing very large chest wall defects.	the reconstruction of large full-thickness chest wall defects after resection of t3/t4 non-small cell lung carcinomas or primary chest wall tumors presents a technical challenge for thoracic surgeons and plays a central role in determining postoperative morbidity. the objective is to evaluate our results in chest wall reconstruction using a combination of expanded polytetrafluoroethylene (eptfe) mesh and titanium plates.	2011	21531380
effects of hyperthyroidism, hypothyroidism and thyroid autoimmunity on female sexual function.	introduction: thyroid hormones affect male and female sexual functions, but data in hypo- and hyperthyroid women are scanty. aim: to investigate sexual function in hypo- and hyperthyroid women before and immediately after restoration of euthyroidism and in women with euthyroid hashimoto's thyroiditis (ht). patients and controls: fifty-six women with thyroid diseases (age 19-50 years; 22 with hyperthyroidism, 17 with hypothyroidism and 17 with euthyroid ht) and 30 age-matched healthy women. main ...	2011	21532331
a preliminary report on the effects of the level of spinal cord injury on the association between central adiposity and metabolic profile.	to determine the effects of the level of injury on visceral adipose tissue (vat), subcutaneous adipose tissue (sat), and the vat:sat ratio in individuals with tetraplegia (t-spinal cord injury [sci]) and paraplegia (p-sci) and the relationships among central adiposity and glucose and lipid profile.	2011	21570032
anal canal cancer: management of inguinal nodes and benefit of prophylactic inguinal irradiation (cors-03 study).	purpose: to evaluate the benefit of prophylactic inguinal irradiation (pii) in anal canal squamous cell carcinoma (ascc). methods and materials: this retrospective study analyzed the outcome of 208 patients presenting with ascc treated between 2000 and 2004 in four cancer centers of the south of france. results: the population study included 35 t1, 86 t2, 59 t3, 20 t4, and 8 t stage unknown patients. twenty-seven patients presented with macroscopic inguinal node involvement. of the 181 patients ...	2011	21570207
moyamoya disease presenting as thalamic hemorrhage in a patient with neuromyelitis optica and sjögren's syndrome.	a 52-year-old woman was admitted to the hospital with right thalamic hemorrhage. a carotid angiogram revealed occlusion of the terminal portions of the bilateral internal carotid arteries with basal moyamoya vessels, which was diagnosed as moyamoya disease (mmd). at 31 years of age, she was diagnosed with multiple sclerosis because of optic neuritis and myelitis. paraplegia appeared 14 days after admission. t2-weighted thoracic magnetic resonance imaging revealed a high intensity lesion extendin ...	2011	21571549
the bacteriophage t4 rapid-lysis genes and their mutational proclivities.	like most phages with double-stranded dna, phage t4 exits the infected host cell by a lytic process requiring, at a minimum, an endolysin and a holin. unlike most phages, t4 can sense superinfection (which signals the depletion of uninfected host cells) and responds by delaying lysis and achieving an order-of-magnitude increase in burst size using a mechanism called lysis inhibition (lin). t4 r mutants that are unable to conduct lin produce distinctly large, sharp-edged plaques. the discovery of ...	2011	21571993
survival benefit of bursectomy in patients with resectable gastric cancer: interim analysis results of a randomized controlled trial.	background: bursectomy is regarded as a standard surgical procedure during gastrectomy for serosa-positive gastric cancer in japan. there is little evidence, however, that bursectomy has clinical benefit. we conducted a randomized controlled trial to demonstrate non-inferiority of treatment with the omission of bursectomy. methods: between july 2002 and january 2007, 210 patients with ct2-t3 gastric adenocarcinoma were intraoperatively randomized to radical gastrectomy and d2 lymphadenectomy wit ...	2011	21573917
impact of endothelial activation on infective and inflammatory complications after cardiac surgery in type ii diabetes mellitus.	purpose: altered endothelial response has been described in diabetics after cardiac surgery. infections and inflammatory organ damage often complicate the postoperative course. we evaluated endothelial/cytokine response (ecr) after cardiac surgery and its role on infective/inflammatory complications of type ii diabetic patients. ?methods: perioperative ecr of 60 diabetic patients (group a) undergoing cardiopulmonary bypass was compared to that of 60 non-diabetics (group b). hemodynamics, endothe ...	2011	21574159
[analysis of the therapeutic efficacy for 60 cases of t4 squamous cell carcinoma of the pyriform sinus].	to evaluate the treatment results of t4 squamous cell carcinoma of the pyriform sinus.	2011	21575488
[surgery for t4 hypopharyngeal cancer and reconstruction after hypopharyngo-oesphagectomy.]	objective: to explore the surgical treatment of hypopharyngeal and cervical esophageal cancers and the ways of reconstruction after hypopharyngo-oesphagectomy, and to evaluate their efficacy. methods: twenty five patients with cancer of the laryngopharynx and cervical esophagus treated in our department between 1995 and 2007 were included in this study. their clinical data were restrspectively analyzed. among them, 17 cases had the tumor originated from the pyriform sinus, 3 of the posterior pha ...	2011	21575524
[effect of the populations of alabama argillacea (hübner) (lepidoptera: noctuidae) on cotton crop at two sowing distances.]	the objective of this research was to evaluate the incidence of damage by the leafworm alabama argillacea (hübner) on yields of cotton grown under rows spaced 0.38 m and 0.76 m at the irrigation area of santiago del estero, argentina. the period evaluated was extended from first flower to first open boll. treatments were t1 - without control of larvae, t2 - with control of larvae, t3 - control since first flower to the end of effective blooming, and t4 - with larval control since the end of effe ...	2011	21584408
splenic artery invasion in pancreatic adenocarcinoma of the body and tail: a novel prognostic parameter for patient selection.	background: the value of splenic vessels invasion (which identified t3 tumors) in prognosis after resection for pancreatic ductal adenocarcinoma (pda) of the body and tail has not been extensively investigated. the goal of this study was to evaluate prognostic factors in pda of the body/tail, emphasizing the role of splenic vessels infiltration. methods: between 1990 and 2008, 87 patients who underwent distal pancreatectomy (dp) for histologically proven pda of the body and tail were analyzed. c ...	2011	21584836
detection of bladder cancer using novel dna methylation biomarkers in urine sediments.	background: bladder cancer remains a lethal malignancy that can be cured if detected early. dna hypermethylation is a common epigenetic abnormality in cancer that may serve as a marker of disease activity.methods: we selected 10 novel candidate genes from the most frequently hypermethylated genes detected by dna microarray and bisulfite pyrosequencing of bladder cancers and applied them to detect bladder cancer in urine sediments. we analyzed dna methylation in the candidate genes by quantitativ ...	2011	21586619
peripheral nerve stimulation of the thoracic paravertebral plexus for chronic neuropathic pain.	persistent post surgical pain is reported in 70% of patients following thoracotomy and mastectomy. this pain is often neuropathic in nature and occasionally it is refractory to traditional medical and interventional management. neurostimulation of peripheral nerves can be a highly effective clinical modality for the management of neuropathic pain. the placement of a percutaneously sited electrode in the thoracic paravertebral plexus offers a new and novel mode of managing refractory thoracic neu ...	2011	21587333
thyroid hormone-induced haemoglobin changes and antioxidant enzymes response in erythrocytes.	thyroid hormones modulate haemoglobin and reactive oxygen species (ros) production, leading to antioxidant changes. this study evaluated the antioxidant response to ros in erythrocytes in hypothyroid and hyperthyroid rats. wistar rats were divided into four groups: control; hyperthyroid (t(4) -12 mg l(-1) in drinking water); sham operated (simulation of thyroidectomy); and hypothyroid (thyroidectomized). four weeks after, blood was collected and haemoglobin and t(4) levels, lipid peroxidation (l ...	2011	21590696
exaggeration is harder than understatement, but practice makes perfect!	previous research on the fakeability of the implicit association test (iat) yielded inconsistent results. the present study simultaneously analyses several relevant factors: faking direction, type of instructions, and practice. furthermore, it takes baseline individual differences into account. after a baseline assessment in a self-esteem iat without faking instructions (t0), participants in the faking conditions then (t1) faked high or low scores without being provided with recommended strategi ...	2011	21592941
long-term outcome of idiopathic hypertrophic thoracic pachymeningitis.	idiopathic hypertrophic spinal pachymeningitis (ihsp) is a comparatively rare disease characterized by hypertrophic inflammation of the dura mater and clinical symptoms that progress from local pain to myelopathy. we report a case of ihsp followed up for 20 years in a 46-year-old man. expansive laminoplasty was performed in 1991, and this case has been previously reported by a co-author. after 17 years, the patient's gait disturbance returned. physical examination and imaging confirmed ihsp that ...	2011	21594749
phase selection and site-selective distribution by tin and sulfur in supertetrahedral zinc gallium selenides.	doping is among the most important methods to tune the properties of semiconductors. for dense phase semiconductors, the distribution of dopant atoms in crystal lattices is often random. however, when the size of semiconductors becomes increasingly smaller and reaches the extreme situation as is the case in chalcogenide supertetrahedral clusters, different chemically distinct sites (e.g., corner, edge, face, and core) occur, which can dramatically affect the doping chemistry at different sites a ...	2011	21595469
[effect of the levels of vascular endothelial growth factor-a and c on the prognosis of patients with larynx carcinoma.]	objectives: in this study, we determined the prognostic importance of vascular endothelial growth factor (vegf)-a and c values and their relationship with tumor stages and neck lymp node involvement and also, the relationship between microvessel density and tumor stage in the pathologic specimens. patients and methods: thirty-three male patients (mean age 57.8±7.2 years; range 49 to 69 years) who underwent surgical treatment for laryngeal squamous cell carcinoma and a control group of 13 healthy ...	2011	21595615
midkine expression in oral squamous cell carcinoma and leukoplakia.	j oral pathol med (2011) background: midkine (mk), a 13-kda heparin-binding growth factor, is overexpressed in various human cancers. however, its role in the development and progression of oral cavity squamous cell carcinoma (ocscc) is still unclear. thus, the aim of this study was to evaluate the expression of mk in samples of ocscc, leukoplakia, and healthy oral mucosa (control). methods: surgically excised specimens from patients with primary ocscc (n = 28) were immunostained for mk, ki-67 ...	2011	21595751
hypothyroidism caused by phenobarbital affects patterns of estrous cyclicity in rats.	we found that repeated treatment with phenobarbital (pb), a thyroid modulator, resulted in a persistent estrous stage in the present study. although the effects of pb in blocking the surge release of luteinizing hormone (lh), inducing anovulation and prolonging the diestrous period has been well established, there is still no research describing the appearance of persistent estrous states in normal cycling rats dosed with pb. to further study this phenomenon, female rats exhibiting regular estro ...	2011	21595753
acute and chronic hypothyroidism are associated with similar left ventricular diastolic dysfunction relative to the euthyroid state: results of doppler echocardiographic comparisons.	background: how the duration of hypothyroidism affects left ventricular diastolic function is not well-characterized. aim: we sought to compare left ventricular diastolic function in acutely vs. chronically hypothyroid patients vs. euthyroid controls, and within individuals while on vs. off t4. subjects and methods: we prospectively performed such comparisons measuring pulsed-wave and color m-mode doppler echocardiographic variables: early or late mitral peak velocities (e wave or a wave, respec ...	2011	21597313
presynaptic filament dynamics in homologous recombination and dna repair.	homologous recombination (hr) is an essential genome stability mechanism used for high-fidelity repair of dna double-strand breaks and for the recovery of stalled or collapsed dna replication forks. the crucial homology search and dna strand exchange steps of hr are catalyzed by presynaptic filaments-helical filaments of a recombinase enzyme bound to single-stranded dna (ssdna). presynaptic filaments are fundamentally dynamic structures, the assembly, catalytic turnover, and disassembly of which ...	2011	21599536
[effect of remifentanil or esmolol on stress response during electric shock therapy in psychiatric patients].	to observe the effects of remifentanil or esmolol on the stress responses during electric shock therapy in psychiatric patients.	2011	21600104
[effect of pediatric tci system for propofol plus remifentanil in pediatric short-duration surgery with laryngeal mask airway anesthesia].	to study the effect of a pediatric tci patent system for propofol plus remifentanil in pediatric short-duration surgery with laryngeal mask airway (lma) anesthesia.	2011	21600128
survival of prototype strains of somatic coliphage families in environmental waters and when exposed to uv low-pressure monochromatic radiation or heat.	the potential use of specific somatic coliphage taxonomic groups as viral indicators based on their persistence and prevalence in water was investigated. representative type strains of the 4 major somatic coliphage taxonomic groups were seeded into reagent water and an ambient surface water source of drinking water and the survival of the added phages was measured over 90 days at temperatures of 23-25 and 4 °c. microviridae (type strain phix174), siphoviridae (type strain lambda), and myoviridae ...	2011	21600626
effect of age on transitional cell carcinoma of the upper urinary tract: presentation, treatment, and outcomes.	objectives: to determine the effect of age on the disease characteristics, treatment administered, and disease-specific survival (dss) for patients with upper tract urothelial carcinoma. the effect of advancing age on the disease extent and survival has not been well delineated in patients with upper tract urothelial carcinoma. methods: using the surveillance, epidemiology, and end results database from the national cancer institute, we identified patients diagnosed with utuc from 1984 to 2004. ...	2011	21601253
enzymatic assembly of overlapping dna fragments.	three methods for assembling multiple, overlapping dna molecules are described. each method shares the same basic approach: (i) an exonuclease removes nucleotides from the ends of double-stranded (ds) dna molecules, exposing complementary single-stranded (ss) dna overhangs that are specifically annealed; (ii) the ssdna gaps of the joined molecules are filled in by dna polymerase, and the nicks are covalently sealed by dna ligase. the first method employs the 3'-exonuclease activity of t4 dna pol ...	2011	21601685
does the nerve of kuntz exist?	a best evidence topic was written according to a structured protocol. the question addressed was, in what proportion of patients is the nerve of kuntz identifiable? a total of 55 papers were found using the reported search, of which six represented the best evidence to answer the clinical question. the authors, date, journal, study type, population, main outcome measures and results are tabulated. the nerve of kuntz was originally described in 1927 as being a connection from the second intercost ...	2011	21602419
[construction of replication-deficient recombinant adenovirus vector with htfpi-2 gene by admax system and expression in u937 monocytes in vitro].	we tried to construct and identify the recombinant replication-deficient adenovirus vector coding for human tissue factor pathway inhibitor 2 (htfpi-2) gene by admax system in hek293 cells. firstly, we obtained htfpi-2 gene from the recombinant plasmid pires2-egfp-tfpi-2 by pcr using primers with restriction endonuclease site of ecori or saci. after digesting the htfpi-2 gene and plasmid pdc316-ires-egfp shuttle vector, we ligated them with t4 ligase and formed the recombinant shuttle vector pdc ...	2011	21604496
a freshwater cyanophage whose genome indicates close relationships to photosynthetic marine cyanomyophages.	bacteriophage s-crm01 has been isolated from a freshwater strain of synechococcus and shown to be present in the upper klamath river valley in northern california and oregon. the genome of this lytic t4-like phage has a 178 563 bp circular genetic map with 297 predicted protein-coding genes and 33 trna genes that represent all 20-amino-acid specificities. analyses based on gene sequence and gene content indicate a close phylogenetic relationship to the 'photosynthetic' marine cyanomyophages infe ...	2011	21605306
cell-free synthesis of a functional g protein-coupled receptor complexed with nanometer scale bilayer discs.	abstract: background: g protein coupled receptors (gpcrs) represent the largest family of membrane proteins in the human genome and the richest source of targets for the pharmaceutical industry. a major limitation to characterizing gpcrs has been the difficulty in developing high-level heterologous expression systems that are cost effective. reasons for these difficulties include inefficient transport and insertion in the plasma membrane and cytotoxicity. additionally, gpcr purification requires ...	2011	21605442
graves' disease: diagnostic and therapeutic challenges (multimedia activity).	graves' disease is the most common cause of hyperthyroidism in the united states. graves' disease occurs more often in women with a female:male ratio of 5:1 and a population prevalence of 1% to 2%. a genetic determinant to the susceptibility to graves' disease is suspected because of familial clustering of the disease, a high sibling recurrence risk, the familial occurrence of thyroid autoantibodies, and the 30% concordance in disease status between identical twins. graves' disease is an autoimm ...	2011	21605717
surgery of pancreatic cancer in the new millennium: better prediction of outcome.	background:: surgery is the only therapy with potentially curative intention in pancreatic cancer. this analysis aimed to determine prognostic parameters in a patient cohort with resected pancreatic adenocarcinoma with a special focus on the revised r1-definition. methods:: between october 2001 and august 2009, data from 1071 consecutively resected patients with pancreatic adenocarcinoma were prospectively collected in an electronical database. parameters tested for survival prediction in univar ...	2011	21606835
factors influencing bone loss in paraplegia.	background and aim: significant bone loss develops in the first months and continues years after spinal cord injury. a cross - sectional comparative study was performed to evaluate factors influencing bone loss in spinal cord injured men with paraplegia.patients and methods: we studied 31 paraplegic men in chronic stage (>1.5 years) in comparison with 30 able-bodied men of similar age, height, and weight. the paraplegic men were allocated into 2 subgroups based on the neurological level of injur ...	2011	21607037
the role of tumor size and patient's age as prognostic factors in laryngeal cancer.	background and aim: the loco-regional recurrence of laryngeal carcinoma in patients who underwent total laryngectomy is related to numerous factors. aim of the present study was to investigate the role of patient's age and tumor size in the recurrence rate of patients. additional aim of the current study was to investigate the possible associations between the size of the tumor and other characteristics.patients and methods: in 1st department of otorhinolaryngology of ahepa university hospital, ...	2011	21607041
spect/ct imaging in children with papillary thyroid carcinoma.	background: spect/ct improves localization of single photon-emitting radiopharmaceuticals. objective: to determine the utility of spect/ct in children with papillary thyroid carcinoma. materials and methods: 20 spect/ct and planar studies were reviewed in 13 children with papillary thyroid carcinoma after total thyroidectomy. seven studies used i-123 and 13 used i-131, after elevating tsh by t4 deprivation or intramuscular thyrotropin alfa. eight children had one study and five children had two ...	2011	21607603
[effects of different film mulch and ridge-furrow cropping patterns on yield formation and water translocation of rainfed potato].	this paper studied the effects of different film mulch and ridge-furrow cropping patterns on the yield formation and water translocation of rainfed potato in the semi-arid area of west loess plateau. comparing with those under traditional harrowed bedding without film mulch (t1), the potato yield under harrowed bedding with film mulching (t2), completely mulched alternating narrow and wide ridges with furrow planting (t3), completely mulched alternating narrow and wide ridges with ridge planting ...	2011	21608252