Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| trimerization of murine tnf ligand family member light increases the cytotoxic activity against the fm3a mammary carcinoma cell line. | light is a member of the tumor necrosis factor ligand superfamily, which plays important roles in inflammatory and immune responses. light forms a membrane-anchored homotrimeric complex on the cell surface and is often processed as a soluble protein. recombinant soluble human light produced by mammalian cells or escherichia coli is functional at nanomolar concentrations. however, there is little information about the biological activity of mouse light (mlight) because of the difficulty in produc ... | 2011 | 21400099 |
| resection and free tissue reconstruction of locally advanced oral cancer: avoidance of lip split. | the purpose of this study is to report the outcomes of patients with locally advanced (t3-t4) oral cancers undergoing surgical resection and free tissue reconstruction without the lower lip-split procedure. in this retrospective chart review, we analyzed 86 consecutive patients presenting between july 2000 and december 2009 at our university-based, tertiary care medical center. the oral site distribution was: 73 (86%) oral cavity, 10 (12%) oropharynx, and 3 (2%) combined. the average specimen vo ... | 2011 | 21400582 |
| liposomes containing glucosyl ceramide specifically bind t4 bacteriophage: a self-assembling nanocarrier formulation. | a unique formulation is described comprising liposomes containing glucosyl ceramide (glucer) in the lipid bilayer to which bacteriophage t4 was attached. binding of the phage t4 did not occur to glycolipids, such as galactosyl ceramide, containing an aldose in which the c-2 or c-4 conformations were not identical to glucose. these results strongly support previous proposals that glucose is a major receptor moiety for t4 binding to escherichia coli. by using the binding of t4 to liposomal glucer, ... | 2011 | 21401373 |
| effect of thyroid hormone replacement therapy on ovarian volume and androgen hormones in patients with untreated primary hypothyroidism. | primary hypothyroidism may be associated with ovarian enlargement and/ or cyst formation. we evaluated the effect of thyroid hormone replacement therapy on hormonal changes, ovarian volume and sonographic appearance. | 2011 | 21403408 |
| anal canal carcinoma treatment results: the experience of a single institution. | prior to the mid-1980s, the treatment of choice for anal cancer was abdominoperineal resection. currently, combined chemoradiation is the standard of care. or objective was to analyze results of treatment for anal canal carcinoma treated with combined chemoradiation. | 2011 | 21403412 |
| cotrel-dubousset instrumentation in neuromuscular scoliosis. | the study design is retrospective. the aim is to describe our experience about the treatment of patients with neuromuscular scoliosis (nms) using cotrel-dubousset instrumentation. neuromuscular scoliosis are difficult deformities to treat. a careful assessment and an understanding of the primary disease and its prognosis are essential for planning treatment which is aimed at maximizing function. these patients may have pelvic obliquity, dislocation of the hip, limited balance or ability to sit, ... | 2011 | 21404030 |
| revealing time bunching effect in single-molecule enzyme conformational dynamics. | in this perspective, we focus our discussion on how the single-molecule spectroscopy and statistical analysis are able to reveal enzyme hidden properties, taking the study of t4 lysozyme as an example. protein conformational fluctuations and dynamics play a crucial role in biomolecular functions, such as in enzymatic reactions. single-molecule spectroscopy is a powerful approach to analyze protein conformational dynamics under physiological conditions, providing dynamic perspectives on a molecul ... | 2011 | 21409227 |
| h2o2 scavenging inhibits g1/s transition by increasing nuclear levels of p27kip1. | the aim of the present study was to evaluate cell cycle regulation by scavenging h(2)o(2) in tumor cells. a significant arrest in the g1 phase of the cell cycle was demonstrated in ch72-t4 carcinoma cells exposed to catalase, associated with a decrease in cyclin d1 and an increase in the cdk inhibitory protein p27(kip1). moreover, we found a differential intracellular distribution of p27(kip1), which remained in the nucleus after catalase treatment. in vivo experiments showed an increase in nucl ... | 2011 | 21411221 |
| longitudinal evaluation of a smoking prevention program for adolescents. | to evaluate a smoking prevention program for adolescents. | 2011 | 21412573 |
| exploring the free-energy landscapes of biological systems with steered molecular dynamics. | we perform steered molecular dynamics (smd) simulations and use the brownian dynamics fluctuation-dissipation-theorem (bd-fdt) to accurately compute the free-energy profiles for several biophysical processes of fundamental importance: hydration of methane and cations, binding of benzene to t4-lysozyme l99a mutant, and permeation of water through aquaglyceroporin. for each system, the center-of-mass of the small molecule (methane, ion, benzene, and water, respectively) is steered (pulled) at a gi ... | 2011 | 21359274 |
| morphometric measurements of cadaveric thoracic spine in indian population and its clinical applications. | analysis of morphometric data obtained from direct measurements of 100 cadaveric thoracic spines in indian population. | 2011 | 21386943 |
| how long can patients with renal cell carcinoma wait for surgery without compromising pathological outcomes? | introduction:: surgical wait times have been shown to be of significance in other malignancies, but limited studies exist in renal cell cancer (rcc). we analyzed surgical waiting time for rcc patients to see if there was an adverse impact on pathological characteristics. methods:: our centre triages rcc patients on the basis of perceived tumour risk. the waiting time for surgery is adjusted stage for stage: clinical t1 at 90 days, t2 at 40 days, t3 and t4 at 30 days. we retrospectively reviewed ... | 2011 | 21388587 |
| role of gonadal and adrenal steroids and thyroid hormones in the regulation of molting in domestic goose. | plasma levels of testosterone (t), 17-+¦-estradiol (e2), progesterone (p4), dehydroepiandrosterone (dhea), corticosterone (b), thyroxine (t4) and triiodothyronine (t3) were monitored during postnuptial and the prenuptial molt in domestic goose (anser anser domesticus) in both sexes. 1. at the beginning of postnuptial molt (when the old, worn dawny-, and cover feathers' loss starts) in ganders, the levels of t, e2, p4 decrease while dhea and b significantly increase. the elevated levels of t4 and ... | 2011 | 21388915 |
| sudden proximal spinal dislocation with complete spinal cord injury one week after spinal fusion in a child with prader-willi syndrome: a case report. | abstract: study design. case report.objective. to describe a sudden spinal cord injury in a girl with prader-willi syndrome (pws) one week after posterior t2-l3 fusion.summary of background data. pws is a genetic disorder characterized by several features including growth deficiency, hypotonia, obesity, and spinal deformities. in pws patients the prevalence of scoliosis and of kyphosis is reported to be 15-86% and 8-40%, respectively. operative treatment carries specific and serious risks in the ... | 2011 | 21394070 |
| t2-t4 sympathectomy versus t3-t4 sympathicotomy for palmar and axillary hyperhidrosis. | to evaluate and compare the immediate and long-term outcomes of videothoracoscopic t2-t4 sympathectomy and t3-t4 sympathicotomy for the treatment of palmar and axillary hyperhidrosis. | 2011 | 21243401 |
| the prevalence of vertebral fractures and health-related quality of life in postmenopausal women. | vertebral fractures are the hallmark of osteoporosis, responsible for increased back pain, impairment of mobility and functional limitations. these factors have an impact on patients' health-related quality of life (qol). the aim of this study was to evaluate the prevalence of vertebral fractures in moroccan postmenopausal women and to assess their qol, using an arabic validated version of qualeffo. the study recruited 347 postmenopausal women in obvious good health. we excluded women who had us ... | 2011 | 21243498 |
| relevance of autoimmune thyroiditis in children and adolescents with vitiligo. | vitiligo is the most common pigmentation-related disorder worldwide. an autoimmune etiology is widely considered, and genetic factors may play an important role in its pathogenesis. the purpose of this study was to assess the incidence of thyroid dysfunctions and autoimmune thyroiditis in children with vitiligo and to identify related factors. | 2011 | 21244381 |
| foxp3 and survival in urinary bladder cancer. | objective: • to investigate the possible impact of foxp3 expression in t-cells, as well as in tumour cells, on long-term survival in patients with urinary bladder cancer (ubc) invading muscle. patients and methods: • in a retrospective study, tumour specimens from 37 patients cystectomized for t1-t4 ubc during 1999-2002 at the karolinska university hospital were examined by immunohistochemistry for tumour expression and/or infiltration of immune cells expressing foxp3 as well as cd3. • the resul ... | 2011 | 21244603 |
| is neoadjuvant chemotherapy prior to radio-chemotherapy beneficial in t4 anal carcinoma? | this study retrospectively describes the outcome of a series of 38 patients (pts) with t4 anal carcinoma exclusively treated by radio and chemotherapy. | 2011 | 21240983 |
| induction chemotherapy for advanced squamous cell carcinoma of the paranasal sinuses. | to review the oncologic outcomes in patients with advanced (stage iii-iv) squamous cell carcinoma of the paranasal sinuses treated with induction chemotherapy prior to definitive local therapy. | 2011 | 21242552 |
| objective evaluation of patients with palmar hyperhidrosis submitted to two levels of sympathectomy: t3 and t4. | this study compares the results obtained of video-assisted sympathectomy performed on two distinct ganglion levels (third vs. fourth thoracic ganglion) in the treatment of palmar hyperhidrosis (ph), through a blind randomized clinical trial. all participants were randomized into two groups of 20 patients (g3 and g4) and underwent the operation, and were followed for 12 months. we used an objective method for measuring sweat, checking the transepidermal water loss (tewl), and evaluated the qualit ... | 2011 | 21233258 |
| endorectal ultrasound in rectal carcinoma--do the literature results really correspond to the realities of routine clinical care? | this multicenter, prospective, country-wide quality-assurance study at more than 300 hospitals in germany was designed to characterize and analyze the diagnostic accuracy of rectal endoscopic ultrasound (eus) in the routine clinical staging of rectal carcinoma (depth of tumor infiltration). | 2011 | 21234855 |
| thyroid status of space shuttle crewmembers: effects of iodine removal. | iodine is often used for water purification and has been used throughout the u.s. space program. because of concern about potential effects on crewmembers' thyroid function, in 1997 a system was implemented on board the space shuttles to remove iodine from water before it was consumed. we report here thyroid hormone data from crews flying before and after this system was implemented. | 2011 | 21235106 |
| plasma acetate, gluconate and interleukin-6 profiles during and after cardiopulmonary bypass: a comparison of plasma-lyte 148 with a bicarbonate-balanced solution. | as even small concentrations of acetate in the plasma result in pro-inflammatory and cardiotoxic effects, it has been removed from renal replacement fluids. however, plasma-lyte 148 (plasma-lyte), an electrolyte replacement solution containing acetate plus gluconate is a common circuit prime for cardio-pulmonary bypass (cpb). no published data exist on the peak plasma acetate and gluconate concentrations resulting from the use of plasma-lyte 148 during cpb. | 2011 | 21235742 |
| immediate effects of the audible pop from a thoracic spine thrust manipulation on the autonomic nervous system and pain: a secondary analysis of a randomized clinical trial. | this study investigated the immediate effects of audible joint sounds following a supine t3-t4 spinal thrust manipulation on the autonomic nervous system activity using a fully automated pupillometry system in patients with chronic neck pain. an additional aim was to determine if audible sounds as perceived by the therapist were associated with the reduction of pain following manipulation. | 2011 | 21237406 |
| endonuclease vii is a key component of the mismatch repair mechanism in bacteriophage t4. | in previous papers we described an extra recombination mechanism in t4 phage, which contributed to general recombination only when particular mutations were used as geneticmarkers (high recombination or hr markers), whereas it was practically inactive towards other riib mutations (low recombination or lr markers). this marker-dependent recombination pathway was identified as a repair of mismatches in recombination heteroduplexes. we suggested that the first step in this pathway, recognition and ... | 2011 | 21237725 |
| analysis of preexistent vertebral rotation in the normal infantile, juvenile, and adolescent spine. | vertebral rotation was systematically analyzed in the normal, nonscoliotic thoracic spine of children aged 0 to 16 years. subgroups were created to match the infantile, juvenile, and adolescent age groups according to the criteria of the scoliosis research society. | 2011 | 21240053 |
| do igf-i concentrations better reflect growth hormone (gh) action in children with short stature than the results of gh stimulating tests? evidence from the simultaneous assessment of thyroid function. | 2011 | 21232100 | |
| does a subcentimeter distal resection margin adversely influence oncologic outcomes in patients with rectal cancer undergoing restorative proctectomy? | a 1-cm distal clearance margin is recommended for mid/low rectal cancers. | 2011 | 21228662 |
| [thoracic spine pseudarthrosis treated by transpleural corporectomy and bone morphogenic protein]. | traumatic thoracic spine instability is a rare but difficult-to-treat entity, particularly above t5 where pedicle screwing is widely regarded as an unsatisfactory option and anterior surgery is considered difficult because of the anatomic relationship with the shoulder and large vessels. | 2011 | 21247607 |
| hypothyroxinemia and pregnancy. | to evaluate the peer-reviewed literature on iodine deficiency and hypothyroxinemia in pregnancy. | 2011 | 21247845 |
| a brief review of voice restoration following total laryngectomy. | despite advances in conservative laryngeal surgery and radiotherapy, total laryngectomy still remains the procedure of choice for advanced-stage (uicc t3 and t4) laryngeal carcinoma, around the world. the functional rehabilitation of the laryngectomized patients has been a concern of head and neck surgeons and speech therapists. significant developments in speech rehabilitation over the past three decades have led to substantial improvements in the quality of life of these patients. the tracheoe ... | 2011 | 21248437 |
| bioenergetic impact of tissue-specific regulation of iodothyronine deiodinases during nutritional imbalance. | the regulation of energy homeostasis by thyroid hormones is unquestionable, and iodothyronine deiodinases are enzymes involved in the metabolic activation or inactivation of these hormones at the cellular level. t3 is produced through the outer ring deiodination of the prohormone t4, which is catalyzed by types 1 and 2 iodothyronine deiodinases, d1 and d2. conversely, type 3 iodothyronine deiodinase (d3) catalyzes the inner ring deiodination, leading to the inactivation of t4 into reverse triiod ... | 2011 | 21249435 |
| the effects of creep and recovery on the in vitro biomechanical characteristics of human multi-level thoracolumbar spinal segments. | several physiological and pathological conditions in daily life cause sustained static bending or torsion loads on the spine resulting in creep of spinal segments. the objective of this study was to determine the effects of creep and recovery on the range of motion, neutral zone, and neutral zone stiffness of thoracolumbar multi-level spinal segments in flexion, extension, lateral bending and axial rotation. | 2011 | 21251737 |
| lithium in drinking water and thyroid function. | background: high concentrations of lithium in drinking water were previously discovered in the argentinean andes mountains. lithium is used worldwide for treatment of bipolar disorder and treatment-resistant depression. one known side effect is altered thyroid function.objectives: we assessed associations between exposure to lithium from drinking water and other environmental sources and thyroid function.methods: women (n = 202) were recruited in four andean villages in northern argentina. lithi ... | 2011 | 21252007 |
| is a right pedicle screw always away from the aorta in scoliosis? | : study design: retrospective analysisobjective: we evaluated the aorta safety in placement of a right pedicle screw in scoliotic patients.summary of background data: past reports emphasized the aorta risk in placing pedicle screws on the concave left side in right thoracic scoliosis. however, risk on the right side has drawn limited interest.methods: thirty-four scoliotic patients with an average age of 18.0 years were evaluated. the cobb angle averaged 59.0°±14.0°. from computed tomographic da ... | 2011 | 21252823 |
| bones and crohn's: no benefit of adding sodium fluoride or ibandronate to calcium and vitamin d. | to compare the effect of calcium and cholecalciferol alone and along with additional sodium fluoride or ibandronate on bone mineral density (bmd) and fractures in patients with crohn's disease (cd). | 2011 | 21253392 |
| commentary on 't4 colorectal cancer: is laparoscopic resection contraindicated?' by bretagnol et al. | 2011 | 21255218 | |
| redox-responsive zinc finger fidelity switch in homing endonuclease and intron promiscuity in oxidative stress. | it is well understood how mobile introns home to allelic sites, but how they are stimulated to transpose to ectopic locations on an evolutionary timescale is unclear. here we show that a group i intron can move to degenerate sites under oxidizing conditions. the phage t4 td intron endonuclease, i-tevi, is responsible for this infidelity. we demonstrate that i-tevi, which promotes mobility and is subject to autorepression and translational control, is also regulated posttranslationally by a redox ... | 2011 | 21256016 |
| aortic endostent followed by extended pneumonectomy for t4 lung cancer. | pulmonary and aortic en bloc resection may be performed with cardiopulmonary bypass support, but is associated with high surgical morbidity and mortality. a 59-year-old man with left lower lobe cancer invading the aorta was considered to be unsuitable for such an extended operation because of previous myocardial infarction, coronary bypass grafts, and subsequent multiple coronary artery stenting. pneumonectomy with en bloc resection of aortic adventitia and media was accomplished after thoracic ... | 2011 | 21256322 |
| comparison of progressive cephalometric changes and postsurgical stability of skeletal class iii correction with and without presurgical orthodontic treatment. | this study compares 1) progressive dental and skeletal changes, 2) postsurgical stability, and 3) treatment efficacy of patients with skeletal class iii correction with and without presurgical orthodontic treatment. | 2011 | 21256648 |
| duplication of calsequestrin genes in teleosts: molecular characterization in the senegalese sole (solea senegalensis). | calsequestrin is a moderate-affinity, high-capacity ca(2+) binding protein in the sarcoplasmic reticulum of skeletal and cardiac muscle that seems to act as an intralumenal ca(2+) buffer. two different isoforms have been described in mammals, the skeletal and cardiac isoforms, encoded by casq1 and casq2 genes, respectively. in this study, we present molecular phylogenetic evidence of a gene duplication event of both calsequestrin genes in teleosts, referred to as casq1a/casq1b and casq2a/casq2b. ... | 2011 | 21256971 |
| mutational analysis of residues in the helical region of the class iia bacteriocin pediocin pa-1. | a 15-mer fragment that is derived from the helical region in the c-terminal half of pediocin pa-1 inhibited the activity of pediocin pa-1. of 13 other pediocin-like (hybrid) bacteriocins, only the hybrid bacteriocin sak/ped was markedly inhibited by the 15-mer fragment. sak/ped was the only one of these bacteriocins that had a sequence (in the c-terminal helix-containing half) identical to that of the 15-mer fragment, indicating that the fragment inhibits pediocin-like bacteriocins in a sequence ... | 2011 | 21257813 |
| a research framework for reducing preventable patient harm. | programs to reduce central line-associated bloodstream infections (clabsis) have improved the safety of hospitalized patients. efforts are underway to disseminate these successes broadly to reduce other types of hospital-acquired infectious and noninfectious preventable harms. unfortunately, the ability to broadly measure and prevent other types of preventable harms, especially infectious harms, needs enhancement. moreover, an overarching research framework for creating and integrating evidence ... | 2011 | 21258104 |
| hedgehog-mediated regulation of thyroid hormone action through iodothyronine deiodinases. | introduction: the three iodothyronine deiodinases catalyze the metabolic pathway that removes one iodine residue from the t4 molecule, thus producing either the active t3 or the inactive metabolite rt3. hence, deiodination is a potent mechanism by which to modulate thyroid hormone (th) action at cellular level, thereby allowing cells to customize their own t3 availability, both spatially and temporally, irrespective of th serum concentrations. sonic hedgehog (hh) regulates patterning and growth ... | 2011 | 21261564 |
| distinct genetic signatures for variability in total and free serum thyroxine levels in four sets of recombinant inbred mice. | c3h/he and balb/c mice have elevated serum thyroxine levels associated with low deiodinase type-1 activity whereas c57bl/6 (b6) mice have low thyroxine levels and elevated deiodinase type-1 activity. high-resolution genetic maps are available for four sets of recombinant inbred (ri) mice derived from b6 parents bred to c3h/he, balb/c, dba/2, or a strains. total and free t4 (t-t4 and f-t4) levels in females from these ri sets (bxh, cxb, bxd, and axbxa) were analyzed to test two hypotheses: first, ... | 2011 | 21209025 |
| archaeal 3'-phosphate rna splicing ligase characterization identifies the missing component in trna maturation. | intron removal from trna precursors involves cleavage by a trna splicing endonuclease to yield trna 3'-halves beginning with a 5'-hydroxyl, and 5'-halves ending in a 2',3'-cyclic phosphate. a trna ligase then incorporates this phosphate into the internucleotide bond that joins the two halves. although this 3'-p rna splicing ligase activity was detected almost three decades ago in extracts from animal and later archaeal cells, the protein responsible was not yet identified. here we report the pur ... | 2011 | 21209330 |
| quantitative methods for measuring dna flexibility in vitro and in vivo. | the double-helical dna biopolymer is particularly resistant to bending and twisting deformations. this property has important implications for dna folding in vitro and for the packaging and function of dna in living cells. among the outstanding questions in the field of dna biophysics are the underlying origin of dna stiffness and the mechanisms by which dna stiffness is overcome within cells. exploring these questions requires experimental methods to quantitatively measure dna bending and twist ... | 2011 | 21195233 |
| serum triiodothyronine level as an indicator of inflammation in patients undergoing dialysis. | introduction. it has been shown that inflammation affects thyroid function. in patients with end-stage renal disease, low plasma triiodothyronine (t3) may be an unsuspected expression of the inflammatory state of these patients. this study evaluated the correlation between t3 and high-sensitivity c-reactive protein (hscrp) levels in patients on peritoneal dialysis (pd) and hemodialysis. materials and methods. this is a cross-sectional study aiming at the correlation between t3 and hscrp levels a ... | 2011 | 21189433 |
| predicting thyroxine requirements following total thyroidectomy. | optimal thyroxine replacement following total thyroidectomy is critical to avoid symptoms of hypothyroidism. the aim of this study was to determine the best formula to determine the initiated replacement dose of levothyroxine immediately following total thyroidectomy. | 2011 | 21198738 |
| developmental trajectories of marijuana use from adolescence to adulthood: personal predictors. | to investigate the relationship between early adolescent personal characteristics and the developmental trajectories of marijuana use extending from early adolescence to adulthood. | 2011 | 21199981 |
| thymidylate synthase genotype-directed neoadjuvant chemoradiation for patients with rectal adenocarcinoma. | downstaging (ds) of rectal cancers is achieved in approximately 45% of patients with neoadjuvant fluorouracil (fu) -based chemoradiotherapy (crt). polymorphisms in the thymidylate synthase gene (tyms) had previously defined two risk groups associated with disparate tumor ds rates (60% v 22%). we conducted a prospective single-institution phase ii study using tyms genotyping to direct neoadjuvant crt for patients with rectal cancer. | 2011 | 21205745 |
| high-pressure epr reveals conformational equilibria and volumetric properties of spin-labeled proteins. | identifying equilibrium conformational exchange and characterizing conformational substates is essential for elucidating mechanisms of function in proteins. site-directed spin labeling has previously been employed to detect conformational changes triggered by some event, but verifying conformational exchange at equilibrium is more challenging. conformational exchange (microsecond-millisecond) is slow on the epr time scale, and this proves to be an advantage in directly revealing the presence of ... | 2011 | 21205903 |
| dual modification of a triple-stranded β-helix nanotube with ru and re metal complexes to promote photocatalytic reduction of co2. | we have constructed a robust β-helical nanotube from the component proteins of bacteriophage t4 and modified this nanotube with ru(ii)(bpy)(3) and re(i)(bpy)(co)(3)cl complexes. the photocatalytic system arranged on the tube catalyzes the reduction of co(2) with higher reactivity than that of the mixture of the monomeric forms. | 2011 | 21206940 |
| reversion-reporter transgenes to analyze all six base-substitution pathways in arabidopsis. | to expand the repertoire of arabidopsis (arabidopsis thaliana) mutation-reporter transgenes, we constructed six mutant alleles in the same codon of the β-glucuronidase-encoding gus transgene. each allele reverts to gus+ only via a particular one of the six transition/transversion pathways. acv5 epitope tags, fused carboxyl terminal to the inactive gus- proteins, enabled semiquantitative immunoassays in plant protein extracts. spontaneous g:c→t:a transversions, previously not measured using repor ... | 2011 | 21212302 |
| direct construction of an open-sandwich enzyme immunoassay for one-step noncompetitive detection of thyroid hormone t4. | to establish a sensitive noncompetitive immunoassay for thyroxine (t4), we attempted to isolate anti-t4 antibodies from a phage display library based on a phagemid pdong1 ( dong et al. anal. biochem.2009, 36, 386 ), which was designed to enable open-sandwich enzyme-linked immunosorbent assay (os-elisa) after selection on immobilized antigen. after the fab-displaying phage library made from the splenocytes of t4-klh immunized mice was subjected to biopanning on t4-bsa, two t4-specific clones were ... | 2011 | 21214207 |
| location of si vacancies and [ti(osi)4] and [ti(osi)3oh] sites in the mfi framework: a large cluster and full ab initio study. | titanium silicalite-1 (ts-1) is an important catalyst for selective oxidation reactions. however, the nature and structure of the active sites and the mechanistic details of the catalytic reactions over ts-1 have not been well-understood, leaving a continuous debate on the genesis of active sites on the ts-1 surface in the literature. in this work, the location of si vacancies and [ti(osi)(4)] and [ti(osi)(3)oh] sites in the mfi (framework type code of zsm-5 (zeolite socony mobile-five)) framewo ... | 2011 | 21214280 |
| target localization and toxicity in dose-escalated prostate radiotherapy with image-guided approach using daily planar kilovoltage imaging. | dose escalation with intensity-modulated radiation therapy (imrt) for carcinoma of the prostate has augmented the need for accurate prostate localization prior to dose delivery. daily planar kilovoltage (kv) imaging is a low-dose image-guidance technique that is prevalent among radiation oncologists. however, clinical outcomes evaluating the benefit of daily kv imaging are lacking. the purpose of this study was to report our clinical experience, including prostate motion and gastrointestinal (gi ... | 2011 | 21214286 |
| l-thyroxine treatment in primary hypothyroidism does not increase the content of free triiodothyronine in cerebrospinal fluid: a pilot study. | the association between cerebrospinal fluid (csf) and serum concentration of thyroid hormones and pituitary thyrotropin stimulating hormone (tsh) was studied in nine hypothyroid patients (ht) before and in seven after l-thyroxine treatment. with l-thyroxine, median free t4 increased 4-fold in serum (3.5 pmol/l vs 17.5 pmol/l) and 3-fold in csf, (3.9 pmol/l vs 11.5 pmol/l). correspondingly, total t3 in serum increased two-fold (0.9 nmol/l vs 2.2 nmol/l). unexpectedly, free t3 concentration in csf ... | 2011 | 21214501 |
| the epiphyseal ring: a long forgotten anatomical structure with significant physiological function. | a descriptive study of the epiphyseal ring's structural design along the thoracolumbar spine. | 2011 | 21224766 |
| 3-t mri with phased-array surface coil in the local staging of rectal cancer. | this study sought to evaluate the diagnostic accuracy of surface-coil 3t magnetic resonance (mr) imaging in the preoperative study of patients with rectal cancer. | 2011 | 21225363 |
| the relationship between thyroid function and bone mineral density in euthyroid healthy subjects in taiwan. | it has been reported that low normal circulating thyrotropin (tsh) levels correlate with lower bone mineral density (bmd) in the korean postmenopausal female. the goal of this study is to evaluate this relationship in different sex and age groups in a chinese population. | 2011 | 21226562 |
| thyroid hormones modulate gaba(a) receptor-mediated currents in hippocampal neurons. | thyroid hormones (ths) play a crucial role in the maturation and functioning of mammalian central nervous system. thyroxine (t4) and 3, 3', 5-l-triiodothyronine (t3) are well known for their genomic effects, but recently attention has been focused on their non genomic actions as modulators of neuronal activity. in the present study we report that t4 and t3 reduce, in a non competitive manner, gaba-evoked currents in rat hippocampal cultures with ic₅₀s of 13±4μm and 12±3μm, respectively. the geno ... | 2011 | 21215272 |
| variation in mutation rates caused by rb69pol fidelity mutants can be rationalized on the basis of their kinetic behavior and crystal structures. | we have previously observed that stepwise replacement of amino acid residues in the nascent base-pair binding pocket of rb69 dna polymerase (rb69pol) with ala or gly expanded the space in this pocket, resulting in a progressive increase in misincorporation. however, in vivo results with similar rb69pol nascent base-pair binding pocket mutants showed that mutation rates, as determined by the t4 phage ri forward assay and rii reversion assay, were significantly lower for the rb69pol s565g/y567a do ... | 2011 | 21216248 |
| induction of reversible meiosis arrest of bovine oocytes using a two-step procedure under defined and nondefined conditions. | the objective was to study the effect of a defined culture system, on nuclear and cytoplasmic maturation of bovine oocytes, using the two-step procedure of ivm to detect possible inhibition and subsequent resumption of meiosis arrest. in the first step, called the prematuration period (pmp), cocs were cultured in t1-non-defined medium (ndm), or t2-defined medium (dm), both for 24 h. in step 2, called the resumption period (rp), cocs were cultured in: ndm (t1); dm + ndm (t3); or dm+dm (t4) for 24 ... | 2011 | 21220166 |
| incidental papillary thyroid carcinoma in a patient presenting with graves' hyperthyroidism and concomitant obstructive sequestered intrathoracic multinodular goiter. | a previously healthy 27-year-old woman presented with a thyroid goiter, symptoms of thyrotoxicosis, and mild respiratory obstruction. the serum thyroid stimulating hormone (tsh) was suppressed, serum t4 was elevated, and 24-hour radioiodine uptake was elevated at 59%. thyroid scintigraphy showed intense uptake in an enlarged gland, with a cold nodule on the right, and a large isolated mass in the mediastinum, with very mild uptake. total thyroidectomy and excision of the mediastinal mass reveale ... | 2011 | 21220984 |
| aggressive surgical approach for patients with t4 gastric carcinoma: promise or myth? | surgical outcomes of multiorgan resection (mor) for t4 gastric carcinoma reported in the literature are widely variable. we herein report a large surgical series of t4 gastric carcinoma. | 2011 | 21222167 |
| nerve-evoked constriction of rat tail veins is potentiated and venous diameter is reduced after chronic spinal cord transection. | despite reduced sympathetic activity below the level of a spinal cord injury (sci), venoconstriction during autonomic dysreflexia increases venous return to the heart. here, contractions of isometrically mounted tail veins from rats with spinal transection at t4 performed 8 - 10 weeks earlier are compared with those from sham-operated rats. after sci, lumen diameter was reduced by ∼30% and the contractions evoked by electrical stimulation of the perivascular axons were larger than control. this ... | 2011 | 21222499 |
| laparoscopic vs open resection for patients with rectal cancer: comparison of perioperative outcomes and long-term survival. | the aim of the study is to assess the safety and oncologic feasibility of laparoscopic-assisted resection for rectal cancer vs open rectal resection as a phase ii pilot study for a planned randomized control trial. | 2011 | 21160307 |
| accuracy of free-hand pedicle screws in the thoracic and lumbar spine: analysis of 6816 consecutive screws. | pedicle screws are used to stabilize all 3 columns of the spine, but can be technically demanding to place. although intraoperative fluoroscopy and stereotactic-guided techniques slightly increase placement accuracy, they are also associated with increased radiation exposure to patient and surgeon as well as increased operative time. | 2011 | 21150762 |
| a comparison of different initialization protocols to obtain statistically independent molecular dynamics simulations. | we study how the results of molecular dynamics (md) simulations are affected by various choices during the setup, e.g., the starting velocities, the solvation, the location of protons, the conformation of his, asn, and gln residues, the protonation and titration of his residues, and the treatment of alternative conformations. we estimate the binding affinity of ligands to four proteins calculated with the mm/gbsa method (molecular mechanics combined with a generalized born and surface area solva ... | 2011 | 21132839 |
| husbands' and wives' alcohol use disorders and marital interactions as longitudinal predictors of marital adjustment. | in this longitudinal study, the relationships among wives' and husbands' lifetime alcoholism status, marital behaviors, and marital adjustment were tested. participants were 105 couples from the michigan longitudinal study (mls), an ongoing multimethod investigation of substance use in a community-based sample of alcoholics, nonalcoholics, and their families. at baseline (t1), husbands and wives completed a series of diagnostic measures, and lifetime diagnosis of alcohol use disorder (aud, as de ... | 2011 | 21133510 |
| long-term aspirin use and the risk of total, high-grade, regionally advanced and lethal prostate cancer in a prospective cohort of health professionals, 1988-2006. | experimental studies suggest a role for aspirin in the chemoprevention of prostate cancer and epidemiological evidence supports a modest inverse association between regular aspirin use and prostate cancer risk, especially for advanced disease. in a prospective cohort study of 51,529 health professionals aged 40-75 years at baseline, we evaluated long-term aspirin use and the incidence of total, high-grade (gleason 8-10, n = 488), regionally advanced (t3b-t4 or n1, n = 228) and lethal prostate ca ... | 2011 | 21128233 |
| effect of low levels of aflatoxin b₁ on performance, biochemical parameters, and aflatoxin b₁ in broiler liver tissues in the presence of monensin and sodium bentonite. | aflatoxins (af) are a major problem in broiler production and are significant economic and public health burdens worldwide. a commercial sodium bentonite (na-b) adsorbent was used to prevent the effect of af [50 µg of aflatoxin b₁ (afb₁)/kg of feed] in broiler productivity, biochemical parameters, macroscopic and microscopic liver changes, and afb₁ liver residues. the influence of na-b (0.3%) and monensin (mon, 100 mg/kg), alone or in combination, was investigated in depth. the dietary treatment ... | 2011 | 21177443 |
| perfluorooctane sulfonic acid exposure increases cadmium toxicity in early life stage of zebrafish, danio rerio. | exposure to perfluorooctane sulfonic acid (pfos) is known to induce thyroid-related adverse effects in aquatic organisms. because an antioxidant defense mechanism is one of the key functions of the thyroid gland, we examined whether preexposure to pfos could disrupt thyroid function and enhance cadmium (cd)-induced oxidative stress in fish. zebrafish embryos were exposed to control or 0.5 mg/l pfos for 7 d after fertilization and subsequently exposed to 0.038 mg/l of cd(2+) or a mixture of the p ... | 2011 | 21184528 |
| the burden of prevalent vertebral fractures is negatively associated with functional outcome in women with hip fracture. | the aim of this study was to investigate the association between the burden of prevalent vertebral fractures and functional outcome in women with hip fracture. | 2011 | 21169744 |
| effect of intravenous lidocaine associated with amitriptyline on pain relief and plasma serotonin, norepinephrine, and dopamine concentrations in fibromyalgia. | the objective of this study was to evaluate the effect of intravenous lidocaine combined with amitriptyline on pain relief and plasma serotonin, norepinephrine, and dopamine levels. | 2011 | 21178598 |
| association of paraoxonase 1 (pon1) polymorphisms with osteoporotic fracture risk in postmenopausal korean women. | there is increasing evidence of a biochemical link between lipid oxidation and bone metabolism. paraoxonase 1 (pon1) prevents the oxidation of low-density lipoprotein (ldl) and metabolizes biologically active phospholipids in oxidized ldls. here, we performed association analyses of genetic variation in pon1 to ascertain its contribution to osteoporotic fractures (ofs) and bone mineral density (bmd). we directly sequenced the pon1 gene in 24 korean individuals and identified 26 sequence variants ... | 2011 | 21187701 |
| single-stranded dna binding proteins unwind the newly synthesized double-stranded dna of model miniforks. | single-stranded dna binding (ssb) proteins are essential proteins of dna metabolism. we characterized the binding of the bacteriophage t4 ssb, escherichia coli ssb, human replication protein a (hrpa), and human hssb1 proteins onto model miniforks and double-stranded-single-stranded (ds-ss) junctions exposing 3' or 5' ssdna overhangs. t4 ssb proteins, e. coli ssb proteins, and hrpa have a different binding preference for the ss tail exposed on model miniforks and ds-ss junctions. the t4 ssb prote ... | 2011 | 21189045 |
| neurologic improvement after thoracic, thoracolumbar, and lumbar spinal cord (conus medullaris) injuries. | retrospective. | 2011 | 21192220 |
| spontaneous intracranial hypotension: efficacy of radiologic targeting vs blind blood patch. | the aim of this study was to evaluate the efficacies and compare the outcomes of targeted and blind epidural blood patch (ebp) treatments of spontaneous intracranial hypotension (sih). | 2011 | 21444899 |
| evaluation of the effect of l-thyroxin therapy on cardiac functions by using novel tissue doppler-derived indices in patients with subclinical hypothyroidism. | subclinical hypothyroidism (sh) is characterized by normal serum free t4 (ft4), free t3 (ft3) levels and increased serum thyroid stimulating hormone (tsh) levels.the aim of this study was to assess the validity of tissue doppler imaging (tdi) in evaluating cardiac effects of sh and to demonstrate the improving effects of l-thyroxin(l-t4) on tdi parameters. | 2011 | 21446380 |
| a pilot feasibility study of tnferade™ biologic with capecitabine and radiation therapy followed by surgical resection for the treatment of rectal cancer. | objective: the purpose of this pilot study was to evaluate the feasibility and tolerability of weekly intratumoral tnferade™ injections combined with concurrent capecitabine and radiotherapy in the treatment of patients with locally advanced rectal cancer. methods: patients with t3, t4, or n+ rectal cancer received radiotherapy to a total dose of 50.4-54 gy in combination with capecitabine 937.5 mg/m(2) p.o. b.i.d. tnferade™ at a dose of 4 × 10(10) particle units was injected into the rectal tum ... | 2011 | 21447969 |
| evaluation of thyroid functions with respect to iodine status and trh test in chronic autoimmune thyroiditis. | objective: chronic autoimmune thyroiditis (cat) is the most common form of thyroiditis in childhood and a frequent cause of acquired hypothyroidism. the objective of this study was to evaluate the thyroid status of childrenand adolescents with cat with respect to iodine status and diagnostic values of thyrotropin-releasing hormone (trh) test. methods: seventy-one children (mean age: 11.6 years) were studied in a retrospective analysis. free thyroxine (t4), thyrotropin (tsh), tsh response to trh ... | 2011 | 21448329 |
| thyroid hypoplasia as a cause of congenital hypothyroidism in monozygotic twins concordant for rubinstein-taybi syndrome. | rubinstein-taybi syndrome (rsts), a genetic disorder characterized by growth retardation, mental deficiency, dysmorphic face, broad thumbs and large toes, generally affects monozygotic twins concordantly. thyroid hypoplasia (th) is a common cause of congenital hypothyroidism (ch) and often accompanies dysmorphic syndromes. a pair of female twins were admitted to our neonatology unit 16 hours after delivery. they were born at 35 weeks of gestation. both twins had an unusual dysmorphic facial appe ... | 2011 | 21448332 |
| prognostic factors of t4 gastric cancer patients undergoing potentially curative resection. | to investigate the prognostic factors of t4 gastric cancer patients without distant metastasis who could undergo potentially curative resection. | 2011 | 21448423 |
| maternal flaxseed diet during lactation programs thyroid hormones metabolism and action in the male adult offspring in rats. | flaxseed has several benefits for health such as improvement in lipid profile; and since thyroid hormones increases cholesterol biliary excretion, we decide to evaluate the programming effect of maternal flaxseed diet during lactation upon thyroid hormone metabolism and action in the adult offspring in rats. at birth, lactating rats were divided into: flaxseed dams (f) - diet with 25% of flaxseed - and controls dams (c). f and c pups received normal diet after weaning and male offspring were sac ... | 2011 | 21448850 |
| chemotherapy/chemoradiation in anal cancer: a systematic review. | results from recent phase iii trials in anal cancer failed to show any benefit for neoadjuvant chemotherapy (nact) with cisplatin, or cisplatin-based consolidation chemotherapy compared to chemoradiation alone for loco-regional control, disease-free survival (dfs) and overall survival (os). | 2011 | 21450408 |
| detection of single-base mutation in rna using t4 rna ligase-based nick-joining or dnazyme-based nick-generation. | a single nucleotide polymorphism (snp) is a common genetic variation when a single nucleotide differs between members of a species or paired chromosome. due to its association with disease susceptibility and drug resistance, snp detection is of great value in studying the variation in drug responses. here we present two quantitative snp detection methods for a single-base mismatch in rna, based on nick-joining and nick-generating activities of t4 rna ligase and dnazyme, respectively. t4 rna liga ... | 2011 | 21453671 |
| qsar classification models for the prediction of endocrine disrupting activity of brominated flame retardants. | the identification of potential endocrine disrupting (ed) chemicals is an important task for the scientific community due to their diffusion in the environment; the production and use of such compounds will be strictly regulated through the authorization process of the reach regulation. to overcome the problem of insufficient experimental data, the quantitative structure-activity relationship (qsar) approach is applied to predict the ed activity of new chemicals. in the present study qsar classi ... | 2011 | 21454014 |
| dynamics of the t4 bacteriophage dna packasome motor: endonuclease vii resolvase release of arrested y-dna substrates. | conserved bacteriophage atp-based dna translocation motors consist of a multimeric packaging terminase docked onto a unique procapsid vertex containing a portal ring. dna is translocated into the empty procapsid through the portal ring channel to high density. in vivo the t4 phage packaging motor deals with y- or x-structures in the replicative concatemer substrate by employing a portal-bound holliday junction resolvase that trims and releases these dna roadblocks to packaging. here using dye-la ... | 2011 | 21454482 |
| postvoid residuals remain unchanged in patients with postoperative thoracic epidural analgesia after thoracotomy. | we found in previous studies that thoracic epidural analgesia (tea) after open renal surgery via lumbotomy significantly impaired bladder function with decreased detrusor contractility and increased postvoid residuals under urodynamic assessment. here we evaluated the effect of tea on bladder emptying in patients undergoing thoracotomy. | 2011 | 21455089 |
| outlasting corticomotor excitability changes induced by 25 hz whole-hand mechanical stimulation. | the objective was to investigate if whole-hand mechanical stimulation (mstim) in the tapping-flutter frequency range induces outlasting post-stimulus changes in the hand region of the primary motor cortex. mstim was delivered to 12 healthy subjects for 20 min using a therapeutic stimulation device (swisswing bmr 2000). frequencies of 10 and 25 hz were tested in separate sessions, and for control additionally the foot sole was stimulated at 25 hz. motor evoked potentials (meps) after single (recr ... | 2011 | 21455615 |
| implicit motor learning promotes neural efficiency during laparoscopy. | an understanding of differences in expert and novice neural behavior can inform surgical skills training. outside the surgical domain, electroencephalographic (eeg) coherence analyses have shown that during motor performance, experts display less coactivation between the verbal-analytic and motor planning regions than their less skilled counterparts. reduced involvement of verbal-analytic processes suggests greater neural efficiency. the authors tested the utility of an implicit motor learning i ... | 2011 | 21455805 |
| identification of differentially expressed thyroid hormone responsive genes from the brain of the mexican axolotl (ambystoma mexicanum). | the mexican axolotl (ambystoma mexicanum) presents an excellent model to investigate mechanisms of brain development that are conserved among vertebrates. in particular, metamorphic changes of the brain can be induced in free-living aquatic juveniles and adults by simply adding thyroid hormone (t4) to rearing water. whole brains were sampled from juvenile a. mexicanum that were exposed to 0, 8, and 18days of 50nm t4, and these were used to isolate rna and make normalized cdna libraries for 454 d ... | 2011 | 21457787 |
| characterization and comparison of the full 3' and 5' untranslated genomic regions of diverse isolates of infectious salmon anaemia virus by using a rapid and universal method. | the 3' and 5' untranslated regions (utrs) of the gene segments of orthomyxoviruses interact closely with the polymerase complex and are important for viral replication and transcription regulation. despite this, the 3' and 5' rna utrs of the infectious salmon anaemia virus (isav) genome have only been partially characterized and little is known about the level of conservation between different virus subtypes. this report details for the first time, the adaptation of a rapid method for the simult ... | 2011 | 21458495 |
| a rexinoid antagonist increases the hypothalamic-pituitary-thyroid set point in mice and thyrotrope cells. | retinoid x receptor (rxr) signaling influences thyrotrope function. synthetic rxr agonists, rexinoids, can cause central hypothyroidism. to test the hypothesis that endogenous rexinoids contribute to the tsh 'set point', tat1 mouse thyrotrope cells were treated with a rexinoid antagonist, lg101208. increasing concentrations of lg101208 significantly increased tshß mrna levels, indicating that the rexinoid antagonist may interfere with rxr-signaling by an endogenous rexinoid in thyrotropes. when ... | 2011 | 21458528 |
| [thyroid hormone resistance syndromes]. | thyroid hormone resistance syndromes are a group of genetic conditions characterized by decreased tissue sensitivity to thyroid hormones. three syndromes, in which resistance to hormone action is respectively due to mutations in the gene encoding for thyroid hormone receptor trß, impaired t4 and t3 transport, and impaired conversion of t4 to t3 mediated by deiodinases. an updated review of each of these forms of resistance is provided, and their pathogenetic mechanisms and clinical approaches ar ... | 2011 | 21459689 |
| phospholipase activities in clinical and environmental isolates of acanthamoeba. | the pathogenesis and pathophysiology of acanthamoeba infections remain incompletely understood. phospholipases are known to cleave phospholipids, suggesting their possible involvement in the host cell plasma membrane disruption leading to host cell penetration and lysis. the aims of the present study were to determine phospholipase activities in acanthamoeba and to determine their roles in the pathogenesis of acanthamoeba. using an encephalitis isolate (t1 genotype), a keratitis isolate (t4 geno ... | 2011 | 21461262 |
| fish thyroidal and stress responses in contamination monitoring--an integrated biomarker approach. | xenobiotics may affect fish endocrine system, making endocrine responses relevant in pollution monitoring. five critical sites in ria de aveiro (portugal), having different contamination profiles, were assessed in comparison to a reference site (torreira), focusing on liza aurata stress (plasma cortisol, glucose and lactate) and thyroidal (plasma thyroid stimulating hormone-tsh, thyroxine-t4 and triiodothyronine-t3) responses. l. aurata at vagos (pahs contaminated) and laranjo (mercury contamina ... | 2011 | 21463897 |