Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| metabolic disorders prevalence in sudden deafness. | the aim of the present study was to establish the frequency of metabolic disorders among patients with sudden deafness and to compare this frequency with data from population surveys. | 2010 | 21243289 |
| age-dependent variation in hormonal concentration and biochemical constituents in blood plasma of indian native fowl. | this experiment was to investigate the age-related changes in hormonal concentration and biochemical constituents of blood plasma in indian native desi fowl. one hundred and sixty two (54 from each breed, i.e., kadaknath (kn), aseel peela (ap), and white leghorn (wlh)) day-old female chicks were randomly divided into nine groups each of 18 chicks (3 groups × 3 replicates). wlh was taken in this study to compare the characteristics of indian native desi fowl. the highest level of estrogen hormone ... | 2010 | 21234314 |
| [the sentinel lymph node mapping in colon cancer]. | malignant tumors of the colon can metastases along the lymphatic system in a sequential way, which means that there will be a first node to be involved and then from this disease will pass to another node and so gradually. the sentinel lymph node is the first lymph node or group of nodes reached by metastasizing cancer cells from a tumor. | 2010 | 21232204 |
| comparative analysis of the revised directive 2010/63/eu for the protection of laboratory animals with its predecessor 86/609/eec - a t4 report. | on 8th september 2010 the long process of revising the eu directive for the protection of laboratory animals was concluded. here a comparative evaluation of the new and old directive is provided. while its ultimate goal is to replace the use of animals, the new directive acknowledges that animals, including nonhuman primates, are still needed for scientific purposes today. importantly, animals have an intrinsic value, which must be respected. there are some major advances for animal welfare, man ... | 2010 | 21240470 |
| [clinical application of "funnel technique" in planting thoracic pedicle screws]. | to evaluate the safety and accuracy of "funnel technique" in planting thoracic pedicle screws. | 2010 | 21265197 |
| sensitivity to low-dose/low-let ionizing radiation in mammalian cells harboring mutations in succinate dehydrogenase subunit c is governed by mitochondria-derived reactive oxygen species. | it has been hypothesized that ionizing radiation-induced disruptions in mitochondrial o₂ metabolism lead to persistent heritable increases in steady-state levels of intracellular superoxide (o₂(•u+2212)) and hydrogen peroxide (h₂o₂) that contribute to the biological effects of radiation. hamster fibroblasts (b9 cells) expressing a mutation in the gene coding for the mitochondrial electron transport chain protein succinate dehydrogenase subunit c (sdhc) demonstrate increases in steady-state level ... | 2010 | 21268708 |
| effect of hypo-and euthyroid status on serum cystatin c levels. | objective: the aim of this study was to investigate the effect of hypo- and euthyroid status on serum cystatin c (cysc) levels in children and to explore whether cysc can be used as a marker of the thyroid status.methods: twenty five patients with hypothyroidism (10m, 15f; mean age:8.7±4.9 years) and 21 healhty age-matched controls (9m, 12f; mean age: 9.7±5.0 years) were included in this study. serum thyrotropin (tsh), free thyroxine (ft4), serum cysc and creatinine levels were studied in patien ... | 2010 | 21274315 |
| hypothyroidism due to hepatic hemangioendothelioma: a case report. | although hemangioendothelioma (hhe) is a commonly encountered hepatic tumor during infancy, hhe-related hypothyroidism is rare. we present a patient who developed hhe-related hypothyroidism during the neonatal period and showed marked improvement in hypothyroidism by regression of hhe. a 28-day-old boy with tsh level of 77 miu/ml on neonatal screening and diagnosed as congenital hypothyroidism was started on l-thyroxine (l-t4) (11 μg/kg/day) therapy on the 21(th) day of life. on physical examina ... | 2010 | 21274327 |
| [pleural metastases from bronchial carcinoma: is a cure possible?]. | the 2009 tnm classification of lung cancer reclassified patients with pleural invasion from stage iiib (t4) to stage iv (m+). however, the 2009 tnm separates patients with pleural metastases (m1a) from patients with others visceral metastases (m1b), the patients with stage m1a having the better prognosis. | 2010 | 21277479 |
| prevalence of hyperthyroidism after exposure during childhood or adolescence to radioiodines from the chornobyl nuclear accident: dose–response results from the ukrainian-american cohort study. | abstract relatively few data are available on the prevalence of hyperthyroidism (tsh concentrations of <0.3 miu/liter, with normal or elevated concentrations of free t4) in individuals exposed to radioiodines at low levels. the accident at the chornobyl (chernobyl) nuclear plant in ukraine on april 26, 1986 exposed large numbers of residents to radioactive fallout, principally to iodine-131 (<sup>131</sup>i) (mean and median doses  =  0.6 gy and 0.2 gy). we ... | 2010 | 20929343 |
| the measurement, definition, aetiology and clinical consequences of neonatal transient hypothyroxinaemia. | this review focuses on neonatal transient hypothyroxinaemia, a condition characterized by temporary postnatal reductions in concentrations of total t4 or free t4, with normal or low concentrations of thyroid stimulating hormone (tsh). there is neither an agreed quantitative definition, nor an agreed mode of measurement for the condition. transient hypothyroxinaemia is not routinely monitored yet it is thought to affect about 50% of preterm infants; it was thought to be without long-term sequelae ... | 2010 | 20930033 |
| the role of facial palsy in staging squamous cell carcinoma of the temporal bone and external auditory canal: a comparative survival analysis. | the role for facial palsy in the pittsburgh staging system for squamous cell carcinoma (scc) of the external auditory canal (eac) is unclear. the objective of this study was to conduct a systematic review of published studies to determine the impact of facial palsy on survival outcomes. | 2010 | 20930655 |
| d2 thr92ala and pparγ2 pro12ala polymorphisms interact in the modulation of insulin resistance in type 2 diabetic patients. | type 2 deiodinase (d2) converts t4 into its active metabolite t3, an essential step in thyroid metabolism. a thr92ala polymorphism in the gene encoding d2 has been inconsistently associated with insulin resistance (ir). recently, it was reported that the d2 thr92ala (rs225014) and the peroxisome proliferator-activated receptor (ppar) γ2 pro12ala (rs1801282) polymorphisms interact in the modulation of metabolic syndrome in nondiabetic subjects. here, we investigated the effect of both polymorphis ... | 2010 | 20930717 |
| [involvement of wnt/beta-catenin signaling in tripchlorolide protecting against oligomeric beta-amyloid-(1-42)-induced neuronal apoptosis]. | this study is to explore whether the wnt/beta-catenin signaling pathway is involved in the process of tripchlorolide (t4) protecting against oligomeric abeta(1-42)-induced neuronal apoptosis. primary cultured cortical neurons were used for the experiments on day 6 or 7. the oligomeric abeta(1-42) (5 micromol x l(-1) for 24 h) was applied to induce neuronal apoptosis. prior to treatment with abeta(1-42) for 24 h, the cultured neurons were pre-incubated with t4 (2.5, 10, and 40 nmol x l(-1)), wnt3 ... | 2010 | 20931782 |
| antibacterial activity of the essential oil of satureja wiedemanniana against bacillus species isolated from chicken meat. | the antimicrobial activity of the essential oil (eo) of satureja wiedemanniana against bacillus spp. isolated from chicken meat was investigated. thirty-seven bacillus strains were isolated from 15 chicken meat samples and examined for proteolytic and lipolytic activities by agar well diffusion assay. of 37 bacillus isolated from raw chicken samples, which based on a clear zone diameter of ≥ 6 mm in agar well diffusion assays for proteolytic activity, 19 bacillus strains were selected for this s ... | 2010 | 20932089 |
| online adaptive radiotherapy for muscle-invasive bladder cancer: results of a pilot study. | purpose: to determine the advantages and disadvantages of daily online adaptive image-guided radiotherapy (rt) compared with conventional rt for muscle-invasive bladder cancer. methods and materials: twenty-seven patients with t2-t4 transitional cell carcinoma of the bladder were treated with daily online adaptive image-guided rt using cone-beam computed tomography (cbct). from day 1 daily soft tissue-based isocenter positioning was performed using cbct images acquired before treatment. using a ... | 2010 | 20932678 |
| morphofunctional modifications in gill mitochondria-rich cells of mozambique tilapia transferred from freshwater to 70% seawater, detected by dual observations of whole-mount immunocytochemistry and scanning electron microscopy. | acute responses of gill mitochondria-rich (mr) cells to direct transfer from freshwater to 70% seawater were examined in a euryhaline teleost mozambique tilapia (oreochromis mossambicus). scanning electron microscopic (sem) observations revealed that apical openings of mr cells were morphologically classified into an apical pit, a convex apical surface, a concave apical surface, and a transitory apical surface. meanwhile, in whole-mount immunocytochemistry with anti-na+/k+-atpase (nka), t4 antib ... | 2010 | 20932930 |
| association of osteopontin and tnf-alpha levels with insulin resistance in obese patients with obstructive sleep apnea syndrome. | objective: the aims of this study were to compare the tnf-alpha and osteopontin levels, to identify the relationship between insulin resistance and osteopontin levels in obese patients with and without obstructive sleep apnea syndrome (osas). method: the study population included 62 obese patients (35 males, 27 females) with osas and was compared with 26 obese patients (16 males, 10 females) without osas as a control group. polysomnographic evaluation, spirometric tests and arterial blood gas sa ... | 2010 | 20935448 |
| the role of thyroid dysfunction in the critically ill: a review of the literature. | during critical illness, patients with no known history of thyroid disorders may experience multiple alterations in their serum thyroid hormone levels. such alterations have been termed sick euthyroid syndrome or, more recently, non-thyroidal illness syndrome (ntis). the laboratory parameters of ntis usually include low serum levels of triiodothyronine (t3), normal or low serum levels of thyroxine (t4) and normal or low serum levels of thyroid-stimulating hormone (tsh). the magnitude of the alte ... | 2010 | 20935602 |
| the binding of synthetic triiodo l-thyronine analogs to human transthyretin: molecular basis of cooperative and non-cooperative ligand recognition. | transthyretin (ttr) is a tetrameric β-sheet-rich transporter protein directly involved in human amyloid diseases. several classes of small molecules can bind to ttr delaying its amyloid fibril formation, thus being promising drug candidates to treat ttr amyloidoses. in the present study, we characterized the interactions of the synthetic triiodo l-thyronine analogs and thyroid hormone nuclear receptor trβ-selective agonists gc-1 and gc-24 with the wild type and v30m variant of human transthyreti ... | 2010 | 20937391 |
| the reliability and validity of three non-radiological measures of thoracic kyphosis and their relations to the standing radiological cobb angle. | hyperkyphosis is implicated in a mounting list of negative outcomes, including higher mortality. hyperkyphosis research is hindered due to difficulties inherent in its measurement. by showing that three clinical measures of kyphosis are suitable for use in large scale, longitudinal, hyperkyphosis studies, we will facilitate much needed research in this field. | 2010 | 20938766 |
| intensity-modulated radiotherapy for oropharyngeal squamous cell carcinoma. | to report the outcomes after intensity-modulated radiotherapy (imrt) for patients with oropharyngeal squamous cell carcinoma. | 2010 | 20938964 |
| a comparison between two imaging techniques for the diagnosis of subacute thyroiditis (de quervain thyroiditis): brief communication. | subacute thyroiditis (sat) or de quervain thyroiditis is a relatively frequent and self-limited condition with a triphasic clinical course. its symptoms can mimic other thyroid, upper respiratory, and ear infections. thyroid ultrasonography (tus), radioactive iodine uptake (raiu), and thyroid scintigraphy (ts) may be used for differential diagnosis. to assess and compare the diagnostic value of thyroid tus and ts in patients on the first phase of a clinically diagnosed sat. | 2010 | 20940543 |
| [influence of prolonged treatment with octreotide on gh, igf i, insulin, acth, cortisol, t3, t4 and tsh secretion in a case of congenital chylothorax]. | congenital chylothorax is a rare condition characterized by the accumulation of lymph fluid in the pleural space that causes respiratory and circulatory dysfunctions, immune deficiencies, hypoalbuminemia, electrolyte imbalance and alterations of the coagulation. mortality rates are elevated and can rise to 50%. therapy consists in conservative treatment based on thoracic drainage combined with total parenteral nutrition or use of low-fat high-protein diet supplemented with medium chain triglycer ... | 2010 | 20940674 |
| anatomical landmarks and skin markers are not reliable for accurate labeling of thoracic vertebrae on mri. | numbering of the thoracic spine on mri can be tedious if c2 and l5–s1 are not included and may lead to errors in lesion level. | 2010 | 20942735 |
| phase ii study of neoadjuvant gemcitabine, pegylated liposomal doxorubicin, and docetaxel in locally advanced breast cancer. | this was a phase ii study to assess the activity of a novel neoadjuvant regimen in locally-advanced breast cancer. | 2010 | 20944176 |
| [nazi action t4 euthanasia programme: historical research, individual life stories and the culture of remembrance]. | the psychiatric patients killed under the disguise of euthanasia during world war ii belong to the group of victims which are often forgotten in public remembrance. for german and austrian psychiatry it is important to include them into the memory of the discipline as well as into european remembrance of the victims of nazi annihilation policy. the patient files of the victims enable us to reconstruct the criterion of economic usefulness for deciding about life or death. but above all the files ... | 2010 | 20859734 |
| variable suppression of serum thyroxine in female mice of different inbred strains by triiodothyronine administered in drinking water. | recombinant-inbred mouse strains differ in their susceptibility to graves'-like hyperthyroidism induced by immunization with adenovirus expressing the human thyrotropin (tsh) receptor. because one genetic component contributing to this susceptibility is altered thyroid sensitivity to tsh receptor agonist stimulation, we wished to quantify thyroid responsiveness to tsh. for such studies, it is necessary to suppress endogenous tsh by administering l-3,5,3′-triiodothyronine (l-t3), with the subsequ ... | 2010 | 20860425 |
| quantification of cyclobutane pyrimidine dimers induced by uvb radiation in conidia of the fungi aspergillus fumigatus, aspergillus nidulans, metarhizium acridum and metarhizium robertsii. | conidia are responsible for reproduction, dispersal, environmental persistence and host infection of many fungal species. one of the main environmental factors that can kill and/or damage conidia is solar uv radiation. cyclobutane pyrimidine dimers (cpd) are the major dna photoproducts induced by uvb. we examined the conidial germination kinetics and the occurrence of cpd in dna of conidia exposed to different doses of uvb radiation. conidia of aspergillus fumigatus, aspergillus nidulans and met ... | 2010 | 20860693 |
| high-temperature optical spectral weight and fermi-liquid renormalization in bi-based cuprate superconductors. | the optical conductivity σ(ω) and the spectral weight w(t) of two superconducting cuprates at optimum doping, bi2sr2-xlaxcuo6 and bi2sr2cacu2o8, have been first measured up to 500 k. above 300 k, w(t) deviates from the usual t2 behavior in both compounds, even though σ(ω→0) remains larger than the ioffe-regel limit. the deviation is surprisingly well described by the t4 term of the sommerfeld expansion, but its coefficients are enhanced by strong correlation, as shown by the good agreement with ... | 2010 | 20868070 |
| structures at risk from pedicle screws in the proximal thoracic spine: computed tomography evaluation. | pedicle screw placement in the proximal thoracic spine may result in unwanted bicortical breach. an understanding of the potential structures at risk is paramount to safe screw placement. | 2010 | 20869005 |
| the role of choline positron emission tomography/computed tomography in the management of patients with prostate-specific antigen progression after radical treatment of prostate cancer. | choline positron emission tomography (pet)/computed tomography (ct) is a currently used diagnostic tool in restaging prostate cancer (pca) patients with increasing prostate-specific antigen (psa) after either radical prostatectomy (rp) or external-beam radiation therapy (ebrt). however, no final recommendations have been made on the use of this modality for patient management. | 2010 | 20869161 |
| biochemical recurrence following robot-assisted radical prostatectomy: analysis of 1384 patients with a median 5-year follow-up. | there is a paucity of data on long-term oncologic outcomes for patients undergoing robot-assisted radical prostatectomy (rarp) for prostate cancer (pca). | 2010 | 20869162 |
| effects of nonylphenol on early embryonic development, pigmentation and 3,5,3'-triiodothyronine-induced metamorphosis in bombina orientalis (amphibia: anura). | nonylphenol (np) is an estrogenic endocrine disruptor in many aquatic species. in an effort to highlight the developmental toxicity of np in amphibians, we examined the effects of np on the embryonic survival, tadpole growth, melanophore development and metamorphosis of a native korean amphibian species, bombina orientalis (anura). when treated to fertilized eggs, 1 μm np significantly decreased embryonic survival at 48 h post fertilization (p.f.), suggesting that 1 μm np can exert systemic toxi ... | 2010 | 20870264 |
| a longitudinal study of the effects of a hope intervention on levels of hope and psychological distress in a community-based sample of oncology patients. | purpose of research: to determine the effect of the hope intervention (hope-in) on levels of hope and psychological distress immediately (t2), 3 (t3), and 12 (t4) months following the intervention; determine the effects of the hope-in on changes in patients' level of hope after controlling for baseline levels of psychological distress; and evaluate patients' level of satisfaction with the hope-in. methods and sample: this single group, longitudinal study recruited a community-based sample which ... | 2010 | 20870459 |
| tumor budding as a strong prognostic indicator in invasive ampullary adenocarcinomas. | prognostication of invasive ampullary adenocarcinomas (aacs) and their stratification into appropriate management categories have been highly challenging owing to a lack of well-established predictive parameters. in colorectal cancers, recent studies have shown that tumor budding confers a worse prognosis and correlates significantly with nodal metastasis and recurrence; however, this has not been evaluated in aac.to investigate the prevalence, significance, and clinical correlations of tumor bu ... | 2010 | 20871215 |
| the impact of preoperative chemoradiotherapy on advanced low rectal cancer. | preoperative chemoradiotherapy (ccrt) followed by radical resection is an option for advanced low rectal cancer. this study was aimed to clarify the impact of ccrt on patients' outcome. | 2010 | 20872811 |
| is surgical resection justified for stage iv colorectal cancer patients having bilobar hepatic metastases?--an analysis of survival of 77 patients undergoing hepatectomy. | surgical indication for stage iv colorectal cancer patients with bilobar hepatic metastases may be controversial. | 2010 | 20872814 |
| prognostic value of the sixth edition of the uicc's tnm classification and stage grouping for oral cancer. | carcinoma of the oral cavity is classified according to the tnm staging system of the uicc. the staging system is under continuous revision. the aim of our study was to assess the prognostic value of the uicc sixth edition for oral cancer, which was established in 2003. | 2010 | 20872947 |
| treatment of paediatric hyperthyroidism but not hypothyroidism has a significant effect on weight. | thyroid hormones are involved in metabolic regulation, but the degree to which they affect body weight and body mass index (bmi) in children is unclear. we examined the effect of hypo- and hyperthyroidism on weight and bmi at the time of diagnosis and after appropriate treatment. | 2010 | 20874768 |
| symptoms experienced by cancer patients during the first year from diagnosis: patient and informal caregiver ratings and agreement. | the aim of this study was to explore the symptom experience of patients with cancer, identify changes in symptoms over time, and explore the congruence of symptom reports between patients and their informal caregivers. | 2010 | 20875175 |
| vinclozolin: a feasibility and sensitivity study of the ilsi-hesi f1-extended one-generation rat reproduction protocol. | feasibility of the ilsi-hesi (acsa) extended one-generation protocol was tested with vinclozolin (dietary 0, 4, 20, 100mg/kg/day). parental wistar rats (n=25/sex/dose) were dosed pre-mating (males 4, females 2 weeks) through f1 offspring weaning (postnatal day pnd21); f1 dosing continued through pnd70. at pnd21, 3 subsets (each 1 pup/sex/litter) were selected for neurotoxicology (functional observational battery, motor activity, neuropathology), clinical pathology (hematology, clinical chemistry ... | 2010 | 20875480 |
| prognostic value of phosphorylated stat3 in advanced rectal cancer: a study from 104 french patients included in the eortc 22921 trial. | signal transducer and activator of transcription 3 (stat3) has been implicated as an oncogene in several neoplastic diseases. however, the biological effects of stat3 have not been extensively studied in rectal carcinogenesis. | 2010 | 20876317 |
| inhibition of cxcr1 and cxcr2 chemokine receptors attenuates acute inflammation, preserves gray matter and diminishes autonomic dysreflexia after spinal cord injury. | female wistar rats (225 g) underwent spinal cord injury (sci) at the t4 segment and were assigned to one of the three groups treated with: (1) saline; (2) 7.5 mg kg(-1) reparixin; or (3) 15 mg kg(-1) reparixin. reparixin is a small molecule, allosteric noncompetitive inhibitor of cxcr1 and cxcr2 chemokine receptors involved in inflammation. | 2010 | 20877331 |
| biweekly docetaxel, cisplatin, and 5-fluorouracil (dcf) chemotherapy for advanced esophageal squamous cell carcinoma: a phase i dose-escalation study. | the optimal chemotherapeutic protocol for the treatment of esophageal cancer has not yet been established. a dose-escalation study of docetaxel combined with cisplatin and 5-fluorouracil (5-fu) was performed to determine the optimal dose in patients with advanced esophageal squamous cell carcinoma. | 2010 | 20878160 |
| ten years single institutional experience of treatment for advanced laryngeal cancer in kyoto university. | it is important to suppress lymph node recurrence and distant metastasis to achieve better survival of advanced laryngeal cancer, especially supraglottic cancer. | 2010 | 20879822 |
| thyroxine induced stress and its possible prevention by catechin. | free radicals are all known to damage cell components. the present study was designed to evaluate the free radical generation in the testis and liver and also to determine the testicular and hepatic antioxidant enzyme activities with and without catechin administration in thyroxine induced male sprague-dawley rats. the experimental animals were divided into four groups, six on each division. l-thyroxine (t4) (0.3 mg/kg body weight) was administered to experimental groups for 15 days. another gro ... | 2010 | 20882757 |
| immediate single tooth replacement with subepithelial connective tissue graft using platform switching implants: a case series. | abstract this case series evaluated the facial gingival stability following single immediate tooth replacement in conjunction with subepithelial connective tissue graft (sctg). implant success rate and peri-implant tissue response were also reported. ten patients (6 males, 4 females), with a mean age of 52.1 (range = 22.7 to 67.1) years, underwent immediate implant placement and provisionalization with sctg and were evaluated clinically and radiographically at pre-surgery (t0), immediately after ... | 2010 | 20883114 |
| the effects of t4 and a3/r phage preparations on whole-blood monocyte and neutrophil respiratory burst. | bacteriophages (viruses of bacteria) are currently considered a promising means of treating antibiotic-resistant infections. the main objective of this study was to evaluate the intensity of the whole-blood monocyte and neutrophil respiratory burst induced by purified preparations and lysates of the bacteriophages t4 and a3/r. while a3/r phage preparations did not induce a significant respiratory burst, t4 phage preparations increased the production of reactive oxygen species in a dose-dependent ... | 2010 | 20883168 |
| remission of hashimoto's thyroiditis in a twelve-year-old girl with thyroid changes documented by ultrasonography. | although it is known that hashimoto's thyroiditis in children and adolescents can go into long-term remission, and that treatment with thyroxine (t4) may not be necessary, it is difficult to quantify changes in the degree of autoimmune destruction of the thyroid. here we report a patient in whom there was a relationship between functional and anatomical changes as assessed by hormone measurements and ultrasonography. | 2010 | 20883175 |
| growth factor receptors gene expression and akt phosphorylation in benign human thyroid nodules are unaffected by chronic thyrotropin suppression. | levothyroxine (l-t4)-based suppression of thyrotropin (tsh) secretion is widely used to prevent the growth of benign thyroid nodules, although the effectiveness of this approach has been demonstrated only in a subset of patients. in this study, we analyzed the in vivo effects of l-t4-mediated tsh suppression on elements of insulin/igf-1-dependent growth-regulating pathways in tissues from patients with benign thyroid nodules. nodular and non-nodular tissue specimens were collected from 63 patien ... | 2010 | 20886414 |
| distance mapping in proteins using fluorescence spectroscopy: the tryptophan-induced quenching (triq) method. | studying the interplay between protein structure and function remains a daunting task. especially lacking are methods for measuring structural changes in real time. here we report our most recent improvements to a method that can be used to address such challenges. this method, which we now call tryptophan-induced quenching (triq), provides a straightforward, sensitive, and inexpensive way to address questions of conformational dynamics and short-range protein interactions. importantly, triq onl ... | 2010 | 20886836 |
| a role for accessory genes ri.-1 and ri.1 in the regulation of lysis inhibition by bacteriophage t4. | lysis inhibition (lin) is a known feature of the t-even family of bacteriophages. despite its historical role in the development of modern molecular genetics, many aspects of this phenomenon remain mostly unexplained. the key element of lin is an interaction between two phage-encoded proteins, the t holin and the ri antiholin. this interaction is stabilized by riii. in this report, we demonstrate the results of genetic experiments which suggest a synergistic action of two accessory proteins of b ... | 2010 | 20945083 |
| diffusion properties of bacteriophages through agarose gel membrane. | a simple two-chamber diffusion method was developed to study the diffusion properties of bacteriophages (phages). the apparent diffusion coefficients (d(app)) of myoviridae phage t4 and filamentous phage fnel were investigated, and the diffusion of the phages was found to be much slower than the diffusion of three antibiotics, ciprofloxacin, penicillin g, and tetracycline. d(app) of t4 and fnel in water through filter paper were calculated to be 2.8 x 10⁻¹¹ m²/s and 6.8 x 10⁻¹² m²/s, respectivel ... | 2010 | 20945479 |
| [efficacy of concomitant therapy with s-1, cdgp, and radiation for laryngeal cancer]. | several clinical trials examining treatment strategies for advanced laryngeal cancer have demonstrated that concurrent chemoradiotherapy is the most effective treatment for improving the patient response to radiotherapy and laryngeal preservation. we evaluated a new regimen of s-1/cdgp(nedaplatin) with radiotherapy (rt), and established that it represented an effective new treatment option that allowed for the preservation of the larynx. | 2010 | 20948253 |
| [a long-term survivor treated with s-1 and gemcitabine for recurrence following an operation for advanced gall bladder cancer]. | the patient was a 75-year-old woman who had undergone an operation for t4, n0: stage iv a gall bladder cancer in may of 2003. uft was given as adjuvant chemotherapy. then s-1 and gemcitabine (gem) were given because of the recurrence of peritoneal dissemination in june 2006. though a partial response was maintained, it was judged as progressive disease in july 2007. the peritoneal tumor was solitary, and an operation was performed. s-1 and gem were given again in january 2008 because of multiple ... | 2010 | 20948268 |
| high rates of regional failure in squamous cell carcinoma of the hard palate and maxillary alveolus. | background.: the purpose of this study was to determine the incidence of neck metastasis in hard palate and maxillary alveolus squamous cell carcinoma (scc) and to identify factors predictive of regional failure. methods.: in 139 patients treated for scc of the hard palate and maxillary alveolus (from 1985-2006), the incidence rates of regional metastasis at presentation and at recurrence were calculated. factors predictive of regional recurrence-free survival were identified on cox multivariabl ... | 2010 | 20949448 |
| auditory processing during sleep in preterm infants: an event related potential study. | auditory processing during sleep was investigated in premature infants by auditory event related potentials (aerps). twenty-six premature infants (mean ga 30 week- range 25-35) admitted to a neonatal intensive care unit were studied, prior to discharge, in active and quiet sleep at a mean post-conceptional age of 35 weeks. infant state was determined by behavioral observation according to standard criteria. an auditory odd-ball paradigm was used with frequently occurring 'standard' tones at 1000 ... | 2010 | 20950966 |
| on the mutagenicity of homologous recombination and double-strand break repair in bacteriophage. | the double-strand break (dsb) repair via homologous recombination is generally construed as a high-fidelity process. however, some molecular genetic observations show that the recombination and the recombinational dsb repair may be mutagenic and even highly mutagenic. here we developed an effective and precise method for studying the fidelity of dsb repair in vivo by combining dsbs produced site-specifically by the segc endonuclease with the famous advantages of the recombination analysis of bac ... | 2010 | 20951652 |
| developmental triclosan exposure decreases maternal and neonatal thyroxine in rats. | disruption of maternal thyroid hormones during fetal developmental may result in irreversible neurological consequences in offspring. the present study tested the hypothesis that perinatal triclosan exposure of dams decreases thyroxine in dams and offspring prior to weaning. pregnant long-evans rats received triclosan by oral gavage (0-300 mg/kg/d) in corn oil from gestational day (gd)6 through postnatal day (pnd)21. serum was obtained from pups on pnd4, 14, and 21, and from dams on pnd22. serum ... | 2010 | 20954233 |
| effect of temperature changes on the occurrence of congenital hypothyroidism. | to investigate an association between seasonal changes in temperature and the prevalence of congenital hypothyroidism (ch) in the southwest of iran. | 2010 | 20956721 |
| [laryngeal function as node metastasis predictor in patients with cancer of the larynx]. | although the possibility of developing cervical node metastases (cnm) in patients with squamous cell carcinoma of the larynx (sccl) depends on the site of tumor origin, other factors may be associated, even in glottic tumors. the objective of this study was to determine factors associated with cnm. | 2010 | 20957813 |
| spinal cord stimulation causes potentiation of right vagus nerve effects on atrial chronotropic function and repolarization in canines. | experimental evidence suggests that spinal cord stimulation (scs) can cause augmentation of parasympathetic influences on the heart via enhanced vagus nerve (vgn) activity. herein, we investigated whether this might lead to enhanced inducibility of vagally mediated atrial tachyarrhythmias (at) and whether such actions depend on intact autonomic neural connections with central neurons. | 2010 | 20958828 |
| neonatal thyroid status in an area of iodine sufficiency. | iodine deficiency constitutes a public health problem in many countries worldwide. fetal neurodevelopment is affected by maternal iodine intake. the aim of present study was to assess urinary iodine excretion (uie) in the 3 trimesters of pregnancy and evaluate its association with newborn thyroid function in tehran, an area of iodine sufficiency. | 2010 | 20959719 |
| [total thyroxine (t4), free thyroxine (ft4)]. | 2010 | 20960783 | |
| harmonization of free thyroid hormone tests: a mission impossible? | the aim of in vitro testing of thyroid function is to accurately reflect the in vivo activity of key analytes, such as thyroid stimulating hormone (tsh), triiodothyronine (t3) and thyroxine (t4). for these key laboratory parameters, it is highly desirable that assay results are interpretable in relation to consensus reference intervals, which should not vary depending on the choice of method used for measurement. the ifcc working group for standardization of thyroid function tests has recently p ... | 2010 | 20961186 |
| adoption of preoperative radiation therapy for rectal cancer from 2000 to 2006: a surveillance, epidemiology, and end results patterns-of-care study. | purpose: the german rectal study determined that preoperative radiation therapy (rt) as a component of combined-modality therapy decreased local tumor recurrence, increased sphincter preservation, and decreased treatment toxicity compared with postoperative rt for rectal cancer. we evaluated the use of preoperative rt after the presentation of the landmark german rectal study results and examined the impact of tumor and sociodemographic factors on receiving preoperative rt. methods and materials ... | 2010 | 20961695 |
| the influence of different student's t mosaic distributions on the extinction factor in mosaic crystals. | during the preparation of versatile tables for the secondary extinction factor y(μ) of cylindrical and spherical mosaic crystals expressed as functions of the bragg angle θ, absorption coefficient times radius μρ and reduced radius τ(0) = σ(0)ρ [σ(0) = (2π)(1/2)q/η], or of θ, τ(0) and ξ(0) = μ/σ(0), five kinds of student's tn probability functions t1, t2, t3, t4, t∞ for describing the mosaic distribution of crystals have been tested. t1 is lorentzian (l) and t∞ is close to gaussian (g). the infl ... | 2010 | 20962374 |
| erythrocyte zinc concentration as an indicator to distinguish painless thyroiditis-associated transient hypothyroidism from permanent hypothyroidism. | red blood cell (rbc) zinc (zn) concentration reflects a patient's mean thyroid hormone level over the preceding several months. the aim of this study was to examine whether rbc zn level can be used as an indicator to distinguish painless thyroiditis-associated transient hypothyroidism (th) from permanent hypothyroidism (ph). rbc zn level was measured in 30 untreated ph patients with hashimoto's thyroiditis and 7 untreated th patients with painless thyroiditis in whom preceding transient thyrotox ... | 2010 | 20962436 |
| large fetal goiter due to placental passage of maternal antithyroperoxidase antibodies. | we report a case of fetal goiter in a pregnant woman with graves-basedow disease. it was diagnosed in the third trimester by a routine ultrasound, and the cordocentesis verified increased levels of thyroxine (t4) and increased autoantibodies (antithyroperoxidase antibodies) that were also increased in maternal blood. fetal goiter got smaller on the follow-up scans, and the newborn presented hypothyroidism. current notions on the diagnosis and management of fetal goiter are briefly discussed. | 2010 | 20962514 |
| analysis of risk factors influencing the development of severe dizziness in patients with vestibular schwannomas in the immediate postoperative phase. | dizziness, a common postoperative symptom in patients with vestibular schwannomas (vss) has a negative effect on the course of recovery, particularly in patients with severe symptoms. reports on incidence and possible risk factors contributing to these symptoms are inconsistent and sometimes even contradictory. in order to establish a profile of patients at risk of severe symptoms in the immediate postoperative phase we retrospectively analyzed data of patients with unilateral vss focusing on th ... | 2010 | 20965648 |
| β-sitosteryl (6'-o-linoleoyl)-glucoside of soybean (glycine max l.) crude extract inhibits y-family dna polymerases. | in the screening of selective dna polymerase (pol) inhibitors, we isolated an acylated steryl glycoside, β-sitosteryl (6'-o-linoleoyl)-glucoside (compound 1), from the waste extract of soybean (glycine max l.) oil. this compound exhibited a marked ability to inhibit the activities of eukaryotic y-family pols (pols η, ι and κ), which are repair-related pols. among mammalian y-family pols, the activity of mouse pol κ was most strongly inhibited by compound 1, with an ic(50) value of 10.2 µm. on th ... | 2010 | 20972363 |
| effects of sex steroid hormones, thyroid hormone levels, and insulin regulation on thyrotoxic periodic paralysis in chinese men. | our study is to determine the expression of thyroid hormone, sex hormone, insulin, and c-peptide in chinese male patients with thyrotoxic periodic paralysis (tpp). this study covered 102 patients with hyperthyroidism from xijing hospital. according to whether occurrence of tpp or not, patients were divided into two groups (those that were hyperthyroid with and without tpp) that were, matched with age, blood pressure, urea, and creatinine. we found the body mass index (bmi) in patients with tpp w ... | 2010 | 20972724 |
| morphine versus oxycodone in pancreatic cancer pain: a randomized controlled study. | according to experimental findings, oxycodone (ox) could have some advantages over morphine (mo) in clinical models of visceral pain. it was hypothesized that ox could have some advantages over mo in terms of efficacy and dose escalation in pancreatic cancer pain. | 2010 | 20973155 |
| primary surgery for oropharyngeal cancer. | the development of new techniques for transoral resection has led to a renewed interest in primary surgical treatment of oropharyngeal squamous cell cancer (scca). we reviewed our experience with primary surgery for oropharyngeal scca to identify factors associated with survival. | 2010 | 20974333 |
| relationship between thyroid hormone levels and regional cerebral blood flow in alzheimer disease. | subclinical thyroid disease and even variations in thyroid function within the normal range is associated with cognitive function and a risk of alzheimer disease (ad). several studies reported the effect of thyroid hormones on cerebral blood flow. the aim of this study was to objectively evaluate regional cerebral blood flow (rcbf) in association with thyroid hormone levels within the normal range in patients with ad. serum thyroid-stimulating hormone (tsh), free t3, and free t4 levels were meas ... | 2010 | 20975518 |
| the effect of injection speed on the spinal block characteristics of hyperbaric bupivacaine 0.5% in the elderly. | the purpose of this prospective, randomized, double-blind study was to compare anesthetic characteristics after two speeds of intrathecal injection of hyperbaric bupivacaine in elderly patients. | 2010 | 20976505 |
| the foxo3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration. | the active thyroid hormone 3,5,3' triiodothyronine (t3) is a major regulator of skeletal muscle function. the deiodinase family of enzymes controls the tissue-specific activation and inactivation of the prohormone thyroxine (t4). here we show that type 2 deiodinase (d2) is essential for normal mouse myogenesis and muscle regeneration. indeed, d2-mediated increases in t3 were essential for the enhanced transcription of myogenic differentiation 1 (myod) and for execution of the myogenic program. c ... | 2010 | 20978344 |
| hypothyroidism of gene-targeted mice lacking kcnq1. | thyroid hormones t3/t4 participate in the fine tuning of development and performance. the formation of thyroid hormones requires the accumulation of i(-) by the electrogenic na(+)/i(-) symporter, which depends on the electrochemical gradient across the cell membrane and thus on k(+) channel activity. the present paper explored whether kcnq1, a widely expressed voltage-gated k(+) channel, participates in the regulation of thyroid function. to this end, kcnq1 expression was determined by rt-pcr, c ... | 2010 | 20978783 |
| evaluation and clinical application of changes in thyroid hormone and tsh levels in critically ill full-term newborns. | the term "euthyroid sick syndrome" (ess) has been used to describe a pattern of thyroid hormone changes during the course of critical illness in adult patients without thyroid disease, often associated with reduced thyroid hormone secretion. objective: to describe the thyroid hormone profile in full-term newborns critically ill compared with thyroid hormone profile of healthy infants, and determine if alterations could be related to the severity of the disease and outcome. | 2010 | 20979446 |
| [effects of parecoxib sodium preemptive analgesia on perioperative cytokine responses and stress responses in patients undergoing ophthalmology surgery]. | to investigate the effects of parecoxib sodium preemptive analgesia on perioperative cytokine responses and stress responses and postoperative analgesia in patients undergoing ophthalmology surgery. | 2010 | 20979906 |
| mandible preserving pull-through oropharyngectomy for advanced oropharyngeal cancer: a pilot study. | through our experiences in the parapharyngeal space (pps) surgery, we have learned that it is possible to gain wide exposure of the pps near to the skull base with a transcervical approach alone. thus, we presumed that if this type of transcervical approach would be combined with a transoral approach, a less invasive oropharyngectomy without mandibulotomy and lip-splitting might be feasible for the resection of advanced oropharyngeal cancer, sparing the morbidities associated with conventional m ... | 2010 | 20980111 |
| escherichia coli rnla and rnlb compose a novel toxin-antitoxin system. | rnase ls was originally identified as a potential antagonist of bacteriophage t4 infection. when t4 dmd is defective, rnase ls activity rapidly increases after t4 infection and cleaves t4 mrnas to antagonize t4 reproduction. here we show that rnla, a structural gene of rnase ls, encodes a novel toxin, and that rnlb (formally yfjo), located immediately downstream of rnla, encodes an antitoxin against rnla. ectopic expression of rnla caused inhibition of cell growth and rapid degradation of mrnas ... | 2010 | 20980243 |
| transcription of the t4 late genes. | this article reviews the current state of understanding of the regulated transcription of the bacteriophage t4 late genes, with a focus on the underlying biochemical mechanisms, which turn out to be unique to the t4-related family of phages or significantly different from other bacterial systems. the activator of t4 late transcription is the gene 45 protein (gp45), the sliding clamp of the t4 replisome. gp45 becomes topologically linked to dna through the action of its clamp-loader, but it is no ... | 2010 | 21029432 |
| transcriptional control in the prereplicative phase of t4 development. | control of transcription is crucial for correct gene expression and orderly development. for many years, bacteriophage t4 has provided a simple model system to investigate mechanisms that regulate this process. development of t4 requires the transcription of early, middle and late rnas. because t4 does not encode its own rna polymerase, it must redirect the polymerase of its host, e. coli, to the correct class of genes at the correct time. t4 accomplishes this through the action of phage-encoded ... | 2010 | 21029433 |
| mobile dna elements in t4 and related phages. | mobile genetic elements are common inhabitants of virtually every genome where they can exert profound influences on genome structure and function in addition to promoting their own spread within and between genomes. phage t4 and related phage have long served as a model system for understanding the molecular mechanisms by which a certain class of mobile dna, homing endonucleases, promote their spread. homing endonucleases are site-specific dna endonucleases that initiate mobility by introducing ... | 2010 | 21029434 |
| t4 genes in the marine ecosystem: studies of the t4-like cyanophages and their role in marine ecology. | from genomic sequencing it has become apparent that the marine cyanomyoviruses capable of infecting strains of unicellular cyanobacteria assigned to the genera synechococcus and prochlorococcus are not only morphologically similar to t4, but are also genetically related, typically sharing some 40-48 genes. the large majority of these common genes are the same in all marine cyanomyoviruses so far characterized. given the fundamental physiological differences between marine unicellular cyanobacter ... | 2010 | 21029435 |
| genomes of the t4-related bacteriophages as windows on microbial genome evolution. | abstract: the t4-related bacteriophages are a group of bacterial viruses that share morphological similarities and genetic homologies with the well-studied escherichia coli phage t4, but that diverge from t4 and each other by a number of genetically determined characteristics including the bacterial hosts they infect, the sizes of their linear double-stranded (ds) dna genomes and the predicted compositions of their proteomes. the genomes of about 40 of these phages have been sequenced and annota ... | 2010 | 21029436 |
| bacteriophage t4 and its relatives. | 2010 | 21029437 | |
| [prognostic value of estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 in node positive breast cancer patients treated by mastectomy]. | to evaluate the prognostic value of estrogen receptor (er), progesterone receptor (pr) and human epidermal growth factor receptor-2 (her-2) in node-positive breast cancer patients treated by mastectomy. | 2010 | 21029696 |
| rosettaepr: an integrated tool for protein structure determination from sparse epr data. | site-directed spin labeling electron paramagnetic resonance (sdsl-epr) is often used for the structural characterization of proteins that elude other techniques, such as x-ray crystallography and nuclear magnetic resonance (nmr). however, high-resolution structures are difficult to obtain due to uncertainty in the spin label location and sparseness of experimental data. here, we introduce rosettaepr, which has been designed to improve de novo high-resolution protein structure prediction using sp ... | 2010 | 21029778 |
| postoperative paralysis following posterior decompression with instrumented fusion for thoracic myelopathy caused by ossification of the posterior longitudinal ligament. | a 60-year-old man presented with thoracic myelopathy due to ossification of the posterior longitudinal ligament (opll). his spinal cord was severely impinged anteriorly by a beak-type opll and posteriorly by ossification of the ligamentum flavum at t4/5. he underwent surgical posterior decompression with instrumented fusion (pdf). immediately after surgery, he developed a brown-séquard-type paralysis, which spontaneously resolved without requiring the addition of opll extirpation. this example h ... | 2010 | 21030260 |
| risk factors associated with the severity of thyroid-associated orbitopathy in korean patients. | the purpose of this study is to identify risk factors for severe thyroid-associated orbitopathy (tao) and compressive optic neuropathy in korean patients. | 2010 | 21052505 |
| the thr92ala 5' type 2 deiodinase gene polymorphism is associated with a delayed triiodothyronine secretion in response to the thyrotropin-releasing hormone-stimulation test: a pharmacogenomic study. | the common thr92ala d2 polymorphism has been associated with changes in pituitary-thyroid axis homeostasis, but published results are conflicting. to investigate the effects of the thr92ala polymorphism on intrathyroidal thyroxine (t4) to triiodothyronine (t3) conversion, we designed prospective pharmacogenomic intervention aimed to detect differences in t3 levels after thyrotropin (tsh)-releasing hormone (trh)-mediated tsh stimulation of the thyroid gland. | 2010 | 21054208 |
| development of a clinical prediction rule for identifying women with tension-type headache who are likely to achieve short-term success with joint mobilization and muscle trigger point therapy. | to identify prognostic factors from the history and physical examination in women with tension-type headache (tth) who are likely to experience self-perceived clinical improvement following a multimodal physical therapy session including joint mobilization and muscle trigger point (trp) therapies. | 2010 | 21054361 |
| thyroxine for transient hypothyroxinemia and cerebral palsy in extremely preterm infants. | background: the relationship of thyroxine supplementation for transient hypothyroxinemia of prematurity to the incidence of cerebral palsy (cp) in infants less than 28 weeks of gestation is unclear. methods: incidence of cp at a corrected age of 18 months was compared between infants born in a 3-year period in which routine measurement of blood free t4 (ft4) was not performed (first period, n = 54), and those born in a later 3-year period in which ft4 was measured (second period, n = 60; mainly ... | 2010 | 21054676 |
| extended staging of oesophageal cancer using fdg-pet - a critical appraisal. | background and aim: oesophageal cancer (oc) is a highly aggressive tumour with unfavorable prognosis due to early stages metastases. treatment and survival rates are highly correlated with tumour wall invasion, lymphatic involvement and metastatic spread. thus, an accurate staging at initial diagnosis is fundamental for optimal management. in the present review article the potential role of the fdg-pet in the staging of oc is discussed. methods: a systematic review of all papers published in pub ... | 2010 | 21055894 |
| correlation of high 18f-fdg uptake to clinical, pathological and biological prognostic factors in breast cancer. | the aim of this study was to determine the impact of the main clinicopathological and biological prognostic factors of breast cancer on (18)f-fluorodeoxyglucose (fdg) uptake. only women with tumours larger than 20 mm (t2-t4) were included in order to minimize bias of partial volume effect. | 2010 | 21057787 |
| [effects of electroacupuncture anesthesia of different frequencies on stress reaction in thyroid surgery]. | to probe into the optimal frequency of electroacupuncture for the access to the best anesthesia. | 2010 | 21058485 |
| anoxybacillus mongoliensis sp. nov., a novel thermophilic proteinase producing bacterium isolated from alkaline hot spring, central mongolia. | a gram reaction positive, spore-forming, facultative anaerobic bacterium belonging to the phylum firmicutes, was isolated from alkaline hot (80 degrees c, ph 9.8 spring tsenher, central mongolia. the cells were rod shaped, feebly motile, peritrichously flagellated. strain t4 was moderately thermophilic with optimum growth at 60 degrees c. maximum temperature for growth was between 70 and 75 degrees c; minimum temperature for growth was between 35 and 30 degrees c. alkalitolerant, optimum ph for ... | 2010 | 21058505 |