Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [epidemiology of infectious mononucleosis]. | 1982 | 6282012 | |
| ebv-iga and new heterophile antibody tests in diagnosis of infectious mononucleosis. | an evaluation has been made of the ebv-iga tests and the immune adherence hemagglutination assay (iaha) as compared with standard diagnostic procedures in 119 serial sera from 22 clinical and 113 sera from 42 subclinical cases of ebv infectious mononucleosis. ebv-iga antibody was demonstrable in 86.4 per cent of patients using eb3 cells as antigen and in 68.2 per cent with p3/hrik cells. for heterophile antibody the iaha test was more sensitive, gave higher titers, and was positive longer than t ... | 1982 | 6282112 |
| [the production of superoxide anion (o2-) by polymorphonuclear cells in patients with rheumatoid arthritis]. | superoxide anion production has been determined in controls and ra patients pmns stimulated with zymosan, rheumatoid synovial membrane, nodule and synovial fluid, rheumatoid factor, aggregated gamma-globulins, mycoplasma and epstein-barr virus. patients with ra showed an increased production of o2- after incubation with zymosan and rheumatoid tissue extracts or synovial fluid in comparison to normal controls. the findings indicate that rheumatoid pmns become activated by different stimuli to pro ... | 1982 | 6282291 |
| a monoclonal immunoblastic sarcoma in donor cells bearing epstein-barr virus genomes following allogeneic marrow grafting for acute lymphoblastic leukemia. | a patient undergoing marrow grafting for acute lymphoblastic leukemia from his partially hla-mismatched sister displayed a widely disseminated immunoblastic sarcoma at autopsy. the tumor was monoclonal by immunoglobulin light-chain staining. blot hybridization analysis, using a cloned highly polymorphic locus in human dna as a probe, showed the tumor to be of donor-cell origin. cytogenetic analysis also demonstrated donor-cell origin. blot hybridization analysis demonstrated epstein-barr virus ( ... | 1982 | 6282364 |
| [liver and sexual freedom (author's transl)]. | 1982 | 6282675 | |
| monoclonal antibodies to epstein-barr virus-induced, transformation-associated cell surface antigens: binding patterns and effect upon virus-specific t-cell cytotoxicity. | spleen cells from mice immunized with epstein-barr virus-transformed lymphoblastoid cells (eb-lcl) were used to generate monoclonal antibodies to cell surface antigens associated with the eb virus-transformed state. radioimmune and immunofluorescence binding assays identified two antibodies, mhm6 and ac2, which reacted consistently with all eb-lcl tested, with a subpopulation of cells in some but not all eb virus genome-positive burkitt lymphoma lines, but with none of a range of eb virus genome ... | 1982 | 6282762 |
| final case reporting from the ugandan prospective study of the relationship between ebv and burkitt's lymphoma. | a prospective epidemiological study was carried out in the west nile district of uganda from 1972 to 1979 in order to investigate the aetiological role of the epstein-barr virus (ebv) in burkitt's lymphoma (bl). by 1976, fourteen bl cases had been detected among the 42,000 children originally bled in the study area. testing of sera from bl candidates and neighbourhood controls showed that children who develop bl later have ebv/vca titres several dilutions higher than their age- and sex-matched n ... | 1982 | 6282763 |
| sera from patients with undifferentiated nasopharyngeal carcinoma contain a factor which abrogates specific epstein-barr virus antigen-induced lymphocyte response. | a unique association of epstein-barr virus (ebv) with the undifferentiated nasopharyngeal carcinoma (npc) is a well acknowledged phenomenon. we report here the detection of a factor present in the sera of npc patients which inhibits the blastogenic response of lymphocytes from ebv seropositive individuals to eb virions or soluble antigens. this lymphocyte-stimulation inhibitor (lsi) was found to be associated with the iga fraction of the serum immunoglobulins. no inhibitory activity was detected ... | 1982 | 6282765 |
| migration inhibition caused by ebv-specific 48k subcomponent of ebna and the associated 53k cellular protein. | leukocytes from ebv-seropositive but not seronegative healthy donors responded with significant migration inhibition to the 48k subcomponent of the epstein-barr virus determined nuclear antigen (ebna), known to carry the virally determined antigenic specificity. a concentration of 10 micrograms/ml was still effective while 5 micrograms/ml had no detectable effect. ebna-associated cellular 53k protein had no effect by itself, but it potentiated the effect of 48k, even if the latter was added at t ... | 1982 | 6282766 |
| alpha 2 hs glycoprotein binds to lymphocytes transformed by epstein-barr virus. | 1982 | 6279438 | |
| complement-fixing antibody to epstein-barr virus soluble antigen in populations at high and low risk for nasopharyngeal carcinoma. | greenland eskimos comprise an ethnic group with one of the highest recorded incidence rates for nasopharyngeal carcinoma in the world. sera from 625 eskimos and 73 danes (caucasians) living in greenland, as well as from 62 danes living in denmark, were tested for complement-fixing antibody to epstein-barr virus (ebv) soluble antigen and, from this study group, 129 donors were matched by age and sex for a study comparing antibody to viral capsid antigen, early antigen, and soluble antigen. both e ... | 1982 | 6279526 |
| decreased purine synthesis during amino acid starvation of human lymphoblasts. | normal human lymphoblasts starved for each of several essential, but not essential, amino acids had decreased dna and rna synthesis but no change in free intracellular purine nucleotides. the rates of purine nucleotide synthesis via the de novo and salvage pathways were measured by incorporating [14c]formate and [14c]hypoxanthine labels, respectively, into lymphoblasts starved for an amino acid or treated with a protein synthesis inhibitor. after 3 h of starvation, purine synthesis via the de no ... | 1982 | 6279630 |
| metallothionein accumulation may account for intracellular copper retention in menkes' disease. | cultured lymphoblasts derived from infants with menkes' disease exhibit the same increased avidity for copper as do fibroblasts and most extrahepatic tissues from these patients. the menkes' cells preferentially take up not only copper but also, on exposure to elevated metal concentrations, the other metallothionein-binding metals, zinc and cadmium. menkes' lymphoblasts contain larger amounts of metallothionein than normal cells following exposure to each of these metals; the amount bound to thi ... | 1982 | 6279642 |
| improved immunofluorescence antigens for detection of immunoglobulin m antibodies to epstein-barr viral capsid antigen and antibodies to epstein-barr virus nuclear antigen. | epstein-barr viral capsid antigen and nuclear antigen produced by modified procedures were evaluated for use in measuring viral capsid antigen immunoglobulin m and epstein-barr virus nuclear antigen antibody responses in sera from patients with suspected epstein-barr virus infections. viral capsid antigen production was stimulated with a phorbol ester, and the epstein-barr virus nuclear antigen cells were fixed in suspension to eliminate loss of antigen during the drying process. both preparatio ... | 1982 | 6279691 |
| detection of infectious mononucleosis heterophil antibody by a rapid, standardized enzyme-linked immunosorbent assay procedure. | a rapid, specific, sensitive, standardized, a reproducible enzyme-linked immunosorbent assay (elisa) procedure has been developed for detecting the heterophil antibody associated with infectious mononucleosis (im). the im heterophil antibody used for the solid phase was purified from bovine erythrocyte stroma. the test uses heavy-chain-specific anti-immunoglobulin m (igm) labeled with alkaline phosphatase and three 10-min incubations. the quantitative results correlated well with horse erythrocy ... | 1982 | 6279695 |
| seroepidemiology of epstein-barr virus in pregnant women. | sera from 2,000 women in the early stages of pregnancy in 1980-1981 were tested for antibodies to epstein-barr virus. of the 2,000 women, 1,386 attended an obstetrical clinic (average age, 21 years) and 614 attended a private practice (average age, 28 years). only eight (0.6%) of the women attending the obstetrical clinic were seronegative (less than or equal to 20 years, five [0.8%] of 650; 21-30 years, three [0.5%] of 648; and greater than or equal to 31 years, zero of 88), whereas 18 (2.9%) o ... | 1982 | 6279737 |
| a non-x-linked syndrome with susceptibility to severe epstein-barr virus infections. | three siblings developed severe (two) or fatal (one) infectious mononucleosis. this family differed from previously described kindreds with a susceptibility to overwhelming epstein-barr virus infections in that: (1) both males and females were affected; (2) they had a history of the recurrent bacterial infections; (3) they produced the full spectrum of antibodies to ebv in the expected range of titers; and (4) survivors recovered completely. two of these youths, but not their parents or an unaff ... | 1982 | 6279813 |
| virus induction by tumor promoters. | 1982 | 6279301 | |
| epstein-barr virus-induced b-cell lymphoma after renal transplantation: acyclovir therapy and transition from polyclonal to monoclonal b-cell proliferation. | 1982 | 6278307 | |
| epstein-barr virus-related dna-binding proteins induced by n-butyrate in p3hr-1 cells. | 1982 | 6278714 | |
| effects of 12-o-tetradecanoyl-phorbol-13-acetate on cell proliferation and epstein-barr virus dna replication. | 1982 | 6278735 | |
| immunoglobulin expression by human b lymphocytes clonally transformed by epstein barr virus. | epstein barr virus (ebv) immortalizes human b lymphocytes, resulting in long-term lymphoblastoid cell lines. to date, such cell lines have typically been derived by suspension culture of mixed mononuclear cells, infected in vivo or in vitro with ebv. we have derived 208 lymphoblastoid lines by clonal transformation of peripheral blood lymphocytes from 3 neonates, 3 normal adults, and 1 patient with systemic lupus erythematosus (sle), utilizing colony formation in agarose and then separate propag ... | 1982 | 6274955 |
| establishment of human t lymphocyte clones highly cytotoxic for an ebv-transformed b cell line in serum-free medium: isolation of clones that differ in phenotype and specificity. | 1982 | 6274958 | |
| t cell-mediated immunoregulation of epstein barr virus- (ebv) induced b lymphocyte activation in ebv-seropositive and ebv-seronegative individuals. | infection with epstein barr virus (ebv) is accompanied by seroconversion and life-long persistence of the virus in b lymphocytes. during acute ebv-induced infectious mononucleosis, suppressor t cells become activated, which may provide an additional mechanism of host defense against the causative agent. when cultures of lymphocytes from normal adults seropositive for ebv were stimulated with the b95-8 strain of ebv, purified b cells produced increasingly higher numbers of immunoglobulin- (ig) se ... | 1982 | 6274959 |
| b lymphoblast antigen (bb-1) expressed on epstein-barr virus-activated b cell blasts, b lymphoblastoid cell lines, and burkitt's lymphomas. | two new cell surface antigens expressed on b lymphoblastoid cell lines (b-lcl) were defined with cytotoxic mouse monoclonal antibodies. one marker, bb-1 (for b lymphoblast antigen-1), was detected on human and nonhuman primate b-lcl, epstein-barr virus (ebv)-activated b cell blasts, most burkitt's lymphomas, and ia+ b lymphoblast-like myelomas. polyclonal b cell activators such as pokeweed mitogen (pwm) and lipopolysaccharide (lps) also induced the expression of bb-1 on immunoglobulin (ig)-posit ... | 1982 | 6274961 |
| abnormal anti-epstein barr virus antibodies in carriers of the x-linked lymphoproliferative syndrome and in females at risk. | the asymptomatic hemizygous female carriers of the x-linked lymphoproliferative syndrome (xlp) have abnormal antibody responses to ebv. this suggests partial expression of the defect that leads to ebv-provoked life-threatening diseases in their affected sons. ebv specific antibodies were measured in 65 serum samples of 12 obligate carrier females and seven of their daughters (females at risk) during periods ranging from 1 to 5 yr. abnormal qualitative antiviral capsid antigen (vca) igg titers we ... | 1982 | 6274962 |
| persistent infection with adenovirus types 5 and 6 in lymphoid cells from humans and woolly monkeys. | chronic infection with adenovirus types 5 and 6 was established in primary mononuclear leukocytes from human umbilical cord blood and in epstein-barr virus (ebv)-transformed b lymphocytes from human umbilical cord blood and from woolly monkey blood. adenovirus could be recovered from cultures of primary leukocytes and of ebv-transformed lymphocytes for two and three months, respectively, without visible alteration of cell growth. infection in cultures of ebv-transformed lymphocytes from woolly m ... | 1982 | 6274968 |
| a quantitative ultrastructural study of peripheral blood lymphocytes containing parallel tubular arrays in epstein-barr virus and cytomegalovirus mononucleosis. | in the normal peripheral circulation there exists a subpopulation of lymphocytes that is ultrastructurally distinct. this lymphocyte is identified with the electron microscope by the presence of cytoplasmic microtubulelike inclusions called parallel tubular arrays (ptas) and contains fc-receptors for cytophilic antibody. in this study, lymphocytes containing ptas (pta-lymphocytes) were quantitated from serial peripheral blood specimens obtained from two patients with epstein-barr virus (ebv) mon ... | 1982 | 6275709 |
| ebv molecular epidemiology: lack of strain role in disease manifestation. | 1982 | 6273728 | |
| cold urticaria in infectious mononucleosis. | 1982 | 6278167 | |
| fatal lymphohistiocytic proliferation owing to epstein-barr virus. | 1982 | 6278168 | |
| human lymphoma-lymphoma hybrids and lymphoma-leukemia hybrids. i. isolation, characterization, cell surface markers, and b-cell markers. | four new somatic cell hybrids were obtained by fusion of various burkitt's lymphoma (bl)-derived cell lines that had different selective markers: raji-p3hr-1, daudi-raji, and a p3hr-1-p3hr-1 "autohybrid" derived from two p3hr-1 sublines. in addition, a hybrid was obtained between the daudi (bl) line and the human leukemia cell line k562. the hybrids were extensively characterized by means of chromosome, isozyme, and hla surface markers. the phenotypic differences between the parent cell lines al ... | 1982 | 6278187 |
| human lymphoma-lymphoma hybrids and lymphoma-leukemia hybrids. ii. epstein-barr virus induction patterns. | in addition to the spontaneous expression of markers of the early and late phases of the viral cycle [epstein-barr virus (ebv), early viral cycle antigens (ea), and viral capsid antigen (vca)] by a panel of hybrid cell lines derived by fusion of human hematopoietic cell lines, the induction of these markers by three chemical inducers [5-iodo-2'-deoxyuridine, the tumor promoter 12-o-tetradecanoylphorbol 13-acetate (tpa), and sodium butyrate] were analyzed. a variant of the prototype producer of ... | 1982 | 6278188 |
| tumor promoter 12-o-tetradecanoylphorbol 13-acetate: effect on complement and epstein-barr virus receptors in human lymphoblastoid cell lines. | the effect of the tumor promoter 12-o-tetradecanoylphorbol 13-acetate (tpa) on the c3 and epstein-barr virus (ebv) receptors in various human lymphoblastoid cells was investigated with the use of the erythrocyte-antibody-complement (eac) rosette formation method and a quantitative bioassay for ebv receptors. tpa caused a significant decrease of c3 receptors in the cultures of both raji and sb4 cells (by approximately 50% of the c3 receptors in untreated cultures at 10 ng/ml). kinetic studies rev ... | 1982 | 6278193 |
| selective inhibition of immunoregulatory cell functions by cyclosporin a. | 1982 | 6278023 | |
| generation in vitro of hla-restricted eb virus-specific cytotoxic human t cells by autologous lymphoblastoid cell lines: the role of previous eb virus infection and foetal calf serum. | 1982 | 6277802 | |
| detection of epstein-barr viral dna internal repeats in the nasopharyngeal mucosa of chinese with iga/ebv-specific antibodies. | fifty-six south chinese individuals exhibiting iga antibodies to ebv for 18 months and presenting nasopharyngeal abnormalities were biopsied. four nasopharyngeal carcinomas, two at a very early stage, were detected. in 14 further individuals, without clinical or histopathological evidence of tumor, ebv/dna internal repeats and/or ebna were detected in the biopsied mucosae. the presence of iga/ebv antibodies and/or ebv markers in the nasopharyngeal mucosa may characterize pre-cancerous conditions ... | 1982 | 6277806 |
| natural and antibody-dependent cell-mediate cytotoxicity to cultured target cells superinfected with epstein-barr virus. | the relationship between natural cell-mediated cytotoxicity (ncmc) and antibody-dependent cell-mediated cytotoxicity (adcc) was examined in an epstein-barr virus-infected target cell system. the total adcc reactivity to epstein-barr virus-infected target cells varied considerably with different effector cells, indicating contributions to specificity by the effector cells as well as by antibodies in the sera. to investigate the role of each reactant, the effector cells, sera, and target cells wer ... | 1982 | 6277480 |
| establishment and characterization of an epstein-barr virus-negative lymphoma b-cell from a patient with a diffuse large cell lymphoma. | cell line (lnpl) was established from a tumor biopsy of a nasopharyngeal "histiocytic" lymphoma composed of large noncleaved b-cells. lnpl expressed immunoglobulin m kappa surface immunoglobulin, as did the original tumor. lnpl also expressed ia antigen but lacked epstein-barr virus nuclear antigen. it exhibited a translocation between chromosomes 8 and 14 which has been described in certain other malignant lymphoproliferative disorders. an autologous t-cell line lacked the translocation between ... | 1982 | 6277483 |
| epstein-barr virus (ebv) receptor implantation onto human b lymphocytes changes immunoglobulin secretion patterns induced by ebv infection. | mosaic membrane vesicles containing both epstein-barr virus (ebv) receptors and sendai virus envelope proteins were allowed to form by the previously described membrane solubilization and co-reconstitution technique. the vesicles were allowed to fuse with the membranes of normal human b lymphocytes, whereafter the cells were infected with transforming ebv (b95-8 substrain). compared to similarly infected but otherwise unmanipulated cells, the receptor-implanted lymphocytes responded with a large ... | 1982 | 6277643 |
| human cancers and human viruses. | 1982 | 6277420 | |
| b cell, helper t cell, and suppressor t cell abnormalities contribute to disordered immunoglobulin synthesis in patients following bone marrow transplantation. | the pathogenic mechanisms responsible for the hypogammaglobulinemia that occurs in patients who have undergone bone marrow transplantation were studied using peripheral blood lymphocytes in an in vitro immunoglobulin biosynthesis assay. none of the nine marrow recipients between 2 and 15 months after transplantation produced normal amounts of igg, iga, or igm in response to pokeweed mitogen (a t cell-dependent activator). however, three of these same patients responded to epstein-barr virus (a h ... | 1982 | 6277055 |
| activation of suppressor t cells by autologous lymphoblastoid cells: a mechanism for feedback regulation of immunoglobulin synthesis. | 1982 | 6276467 | |
| virus-associated hemophagocytic syndrome or malignant histiocytosis? | 1982 | 6276521 | |
| case records of the massachusetts general hospital. weekly clinicopathological exercises. case 9-1982. atypical white cells in the blood of an elderly woman. | 1982 | 6276749 | |
| new epstein-barr virus variants from cellular subclones of p3j-hr-1 burkitt lymphoma. | 1982 | 6276755 | |
| the immunology of cancer of the head and neck with particular reference to oral cancer. | 1982 | 6276835 | |
| [reactivation of epstein-barr virus during primary cytomegalovirus infection in the healthy adult]. | 1982 | 6276860 | |
| dna and protein synthesis in normal and transformed lymphocytes exposed to abrin. | the dose dependent effects of abrin, a toxic d-galactose binding plant lectin, on 3h-tdr and 14c-leucine uptake are studied in normal and epstein barr virus (ebv) transformed lymphocyte cultures. results show that while abrin is highly toxic to both the dna and protein synthesis in ebv lymphocytes, some toxicity to the normal cells is also seen. it is postulated that lymphocyte dna synthesis is affected by ribosomal shutdown induced by the abrin. | 1982 | 6276906 |
| [studies on serum complement fixation antibodies to epstein-barr virus in tupaias]. | 1982 | 6299595 | |
| effects of deoxyadenosine on the activation of ada inhibited t & b cells. | using an in vitro model of adenosine deaminase deficiency, we have shown that the triggering of t lymphocyte proliferation by pha is inhibited by concentrations of deoxyadenosine likely to occur in the plasma of ada deficient children with severe combined immunodeficiency (ada-scid). prostaglandin e1 increases the sensitivity of t cells to this inhibition, suggesting that derangement of cyclic nucleotide metabolism underlies the profound t lymphopaenia seen in ada-scid and in patients treated wi ... | 1982 | 6299634 |
| [a modified 131 i immuno-autoradiographic method for detection of serum eb virus vca-iga antibody in nasopharyngeal carcinoma]. | 1982 | 6299669 | |
| [dietary behavior, way of life, and nasopharyngeal cancer]. | nasopharyngeal carcinoma is prevalent in southeast asia, maghreb countries and greenland/alaska. this cancer, wherever prevalent, is closely associated to the epstein-barr virus (ebv), but its geographical repartition also suggests the possibility of a cultural factor. a comparison of food habits and way of life of cantonese, maghreb populations and eskimos shows certain common points: dried fish or meat, fermented and sometimes rotten, as well as salt preserved vegetables. certain berries of eu ... | 1982 | 6299438 |
| special series: infectious diseases and the office laboratory. edited by james k. todd, m.d. a diagnostic approach to epstein-barr virus infections. | 1982 | 6298756 | |
| membrane igd expression and dynamics in clones of human b-lymphoblastoid cells. | 1982 | 6299157 | |
| effect of cyclosporin a on the production of interferon by human peripheral blood leukocytes in vitro. | cyclosporin a (csa) was assessed for its effect on the production of antiviral activity by human peripheral blood leukocytes (pbl). csa markedly reduced the production of interferon-gamma (ifn-gamma) in response to stimulation with lectin mitogens, bacterial products, alloantigens, or epstein-barr virus (ebv)-transformed lymphoblastoid cell lines (lcl). csa-mediated suppression of ifn-gamma secretion was dose-dependent and did not result from a shift of kinetics of the production of antiviral ac ... | 1982 | 6299190 |
| [detection of intracellular herpes virus antigens by immuno-enzyme procedures]. | the antigens of herpes simplex virus types 1 and 2 are detected and localized in vitro in hep-2 cells by indirect and direct immunoperoxidase. the direct procedure is applied successfully for the diagnosis of genital disease on cytosmears of cervical cells of patients with herpes simplex type 2 infection. with other procedures, as anti-complement immunoperoxidase (acip) and anti-igg immunoperoxidase (aiip) the epstein-barr nuclear antigen (ebna) was detected precisely in eb3, jijoye and raji lym ... | 1982 | 6299829 |
| [theory and practice of the serology of epstein-barr virus]. | 1982 | 6299831 | |
| organophosphorous compounds as inhibitors of ebv infection and transformation. | phosphonoformic acid trisodium salt (pf), ethyl diethyl-phosphonoformate (et-pf), phosphonoacetic acid (paa), ethyl diethyl phosphonoacetate (et paa), ethyl diethyl-2-phosphonopropionate (et-2-ppa) and ethyl diethyl-3-phosphonopropionate (et-3-ppa) were tested as inhibitors of ebv virus capsid antigen (vca) synthesis in b.95-8 cells by immunofluorescence. the most effective inhibitors were: pf, inhibition of 96.74 percent of vca synthesis at a concentration of 500 microm and paa, inhibition of 8 ... | 1982 | 6299860 |
| antibodies to common viruses in sera from patients with multiple myeloma. | the results of screening for antibodies against rubella, morbilli, mumps, herpes simplex, rota and epstein-barr virus in serum from patients with multiple myeloma are reported. antibodies against herpes simplex virus were found in all samples, present in high titres in most samples. antibody titres against the other five viruses were generally low. a possible association of common virus infections and myelomatosis is discussed. | 1982 | 6301212 |
| [infectious hepatitis. the virus, epidemiology and prevention]. | 1982 | 6301389 | |
| nasopharyngeal carcinoma in japan--clinical evaluation of ebv serology and ebv-associated nuclear antigens test. | this study was aimed at the possible clinical application of two epstein-barr virus (ebv) immunological tests to japanese nasopharyngeal carcinoma (npc). one of them was serological test to measure antibody titers to ebv-associated antigens (viral capsid antigens (vca) and virus-induced early antigens (ea)) of 42 npc sera. the other was for the detection of ebv-associated nuclear antigens (ebna) in 22 tumour cells of npc. the results showed that significant elevation of antibody titers to vca an ... | 1982 | 6301414 |
| epstein-barr virus and rheumatoid arthritis: are rheumatoid arthritis associated nuclear antigen and epstein-barr virus nuclear antigen different? | in order to investigate the relationship between antibodies to rana and other epstein-barr virus induced antigens, we have tested 50 sera from subjects without rheumatoid arthritis and with various ebv serology patterns for arana, aea, avca, aebna. patients were either suffering from burkitt's lymphoma, infectious mononucleosis, nasopharyngeal carcinoma, hodgkin's disease or immunodeficiencies, or were healthy controls. rana was detected by indirect immunofluorescence on g1 synchronized raji cel ... | 1982 | 6301567 |
| [study of the antibodies to epstein-barr virus capsid antigen in the diagnosis of infectious mononucleosis in children]. | 1982 | 6302631 | |
| epstein-barr virus-specific cytotoxic t cell responses in rheumatoid arthritis patients. | the level of epstein-barr (eb) virus-specific cytotoxic t cell responsiveness was measured in 21 patients with active, progressive rheumatoid arthritis (ra). a significant number (8 out of 20) of eb virus sero-positive patients showed a markedly impaired responsiveness when compared with a control group of healthy individuals. serological responses of the ra patients to eb virus antigens were not significantly different from the control group. the defect in eb virus-specific cellular immunity sh ... | 1982 | 6302817 |
| b-lymphocyte subpopulation which forms rosettes with mouse erythrocytes increased in rheumatoid arthritis. | we studied the peripheral blood lymphocytes of 22 patients with rheumatoid arthritis (ra) for the presence of a subpopulation of cells which form rosettes with mouse erythrocytes. in normal subjects these cells have been characterised as immature b cells which are non-responsive to pokeweed mitogen. the mean percentage of mouse rosette-forming cells (mrfc) in the rheumatoid group was 13 +/- 10(mean +/- 2 sd), a significantly higher value than the control mean of 5% +/- 4% (p less than 0.001). th ... | 1982 | 6302818 |
| [histopathologic, ultrastructural, immunologic and virologic study of gibert's pityriasis rosea]. | a complete study of pityriasis rosea (gibert) has been performed; this study includes: --a pathological and ultrastructural examination of the skin biopsies; --an immunological study: direct and indirect immunofluorescence (seric anti-cutaneous antibodies); --a virological investigation: ultrastructural examination of the specimens, inoculation of homogenized-skin specimens to 3 cellular cultures; --serological investigations for influenza a, b, parainfluenza 1, 2, 3, adenovirus, respiratory syn ... | 1982 | 6303189 |
| a new epstein-barr virus negative burkitt's lymphoma derived cell-line. i. analysis of cell surface markers and abnormal expression of hla antigens. | chev, a new epstein-barr virus negative burkitt's lymphoma derived cell line has been studied. karyotype analyses demonstrated the t (8; 14) characteristic translocation. cell surface characterisation of this line showed the presence of mu and chi immunoglobulin chains and beta 2-microglobulin and the absence of the complement receptor. we are unable to detect hla--a, b alloantigens on the cell surface which was in contrast with an apparently normal expression of these antigens in the cytoplasm. | 1982 | 6289490 |
| hla-dr typing of fetal human spleen and liver lymphoblastoid cells transformed by epstein-barr virus. | because few hla-dr-positive cells are present in the fetal spleen and liver, full hla typing cannot be performed. however, b lymphocyte precursors can be transformed with epstein-barr virus to produce lymphoblastoid cells which express hla-a, b, and dr antigens. successful transformation was achieved, usually with spleen and liver, in nine fetuses aged from 15 to 18 weeks, mostly within 7 to 14 days of initiation of the cultures. spleen-derived lymphoblasts were more suitable for typing because ... | 1982 | 6289497 |
| varied responses of human b-lymphoblastoid cell lines to infection with vesicular stomatitis virus. | 1982 | 6289524 | |
| a sensitive method for detecting cells coated with antibodies with human monoclonal rheumatoid factor produced in vitro. | a human monoclonal rheumatoid factor (rf) produced in vitro by an epstein-barr virus immortalized cell line has been used to detect and quantitate antibodies specifically bound to cells. the rf is purified from cell culture supernatant by a simple procedure and then radiolabeled. in this assay, the binding of 125i-labeled rf to cells coated with specific antibodies is determined. this rf method detects very low titers of antibodies directed against specific cellular antigens and also minorities ... | 1982 | 6294184 |
| association of epstein-barr virus with acute exudative tonsillitis. | this report is concerned with acute exudative tonsillitis as a pathologic response to the epstein-barr virus (ebv). the concept of a bacterial-viral etiology etiology for tonsillitis has been suggested, and previous studies implicate ebv as a major pathogen in exudative tonsillitis. a prospective study of 16 patients with this diagnosis was conducted. ebv serologic data plus viral and bacterial throat cultures were compiled and evaluated. ebv as a casual agent alone or concurrent with other orga ... | 1982 | 6283456 |
| immunologic studies on cancer of the upper aerodigestive tract. | two interesting findings have emerged from these studies. first, the nk susceptibility of ebv-related cell lines is dependent upon the state of the virus within the cells. ebv-positive cells were more competitive than their ebv-negative counterparts, and induction of the viral cycle in the ebv-positive cells further increased their ability to inhibit nk reactivity against k562. the implications of this finding with regard to surveillance against, and treatment of, ebv-related disease were discus ... | 1982 | 6283457 |
| early antigen titers in pediatric patients with acute cervical lymphadenitis. | eight pediatric patients with acute cervical lymphadenitis or neck mass, alone or in association with nonspecific upper respiratory complaints, were screened for the presence of a primary or reactivation epstein-barr virus infection. all were found to have elevated antibodies to the early antigen (ea) and 75% (6) of these were found to be reactivations. only one had a positive heterophile. half of the patients had elevation of the ea-specific iga, and 75% (6) had elevation of viral capsid antige ... | 1982 | 6283458 |
| induction of antibody-producing cell lines by epstein-barr virus. | this work makes a critical evaluation of ebv transformation as a tool for establishing human antibody producing lines. since steinitz et al. described the technique in 1977, at least 9 lymphoid cell lines with predetermined specificities have been reported with activity against nnp, tnp, a-cho, phosphorylcholine, human ig, rh-d antigen and tetanus toxoid. most successful attempts were based on the choice of immune donors and on the adequate selection of peripheral antigen-specific b cells with a ... | 1982 | 6283460 |
| cellular and epstein-barr virus specific dna polymerases in virus-producing burkitt's lymphoma cell lines. | we have determined the levels of cellular dna polymerases and epstein-barr virus specific dna polymerase in three burkitt's lymphoma cell lines producing varying amounts of ebv, one of which was induced by 12-0-tetra-decanoylphorbol-13-acetate (tpa). there was a proportional increase in the level of ebv-dna polymerase with an increase in the percent of virus-producing cells. however, there was a reciprocal relationship between the levels of ebv-dna polymerase and dna polymerase alpha i.e., in ce ... | 1982 | 6283481 |
| membrane antigen on epstein--barr virus-infected human b cells recognized by a monoclonal antibody. | this paper describes a monoclonal antibody (b532) that detects a membrane antigen present on greater than or equal to 95% of the b cells from lines carrying the epstein-barr virus (ebv) genome. evidence suggesting that b532 is ebv-related was originally obtained by using a cell-binding radioassay with different cell line substrates. immunofluorescence and cell-sorter analysis confirmed that the antigen was present in high density on all ebv-infected lymphoblastoid b-cell lines, but not on ebv-ne ... | 1982 | 6283539 |
| cell growth transformation by herpes simplex virus. | 1982 | 6283599 | |
| epstein-barr-virus nuclear antigen. | 1982 | 6283600 | |
| solid-phase radioimmunoassays for epstein-barr virus associated antigens. | 1982 | 6283618 | |
| the b95-8 isolate of epstein-barr virus arose from an isolate with a standard genome. | blot hybridization studies revealed that the deletion which characterizes the dna from the b95-8 strain of epstein-barr virus was not present in the virus from which the b95-8 strain was derived (883l). the deletion event must have occurred during establishment of the b95-8 cell line or very soon afterward, since the deletion was present in epstein-barr virus dna from a cell line established with b95-8 virus soon after it became available. the presence of the deletion correlates with decreased e ... | 1982 | 6294325 |
| identification and nucleotide sequences of two similar tandem direct repeats in epstein-barr virus dna. | epstein-barr virus dna is known to have partially homologous segments, designated dl and dr, near the left and right ends of the long unique region (raab-traub et al., cell 22:257-267, 1980). dl and dr are each partially composed of tandem direct repeat sequences. dl contains 11 to 14 repeats of a 124-base-pair sequence designated ir2. dr contains approximately 30 direct repeats of a 103-base-pair sequence designated ir4. the dl and dr sequences have colinear partial homology for approximately 2 ... | 1982 | 6294332 |
| non-immortalizing p3j-hr-1 epstein-barr virus: a deletion mutant of its transforming parent, jijoye. | the p3j-hr-1 strain of epstein-barr virus (ebv) fails to immortalize human lymphocytes. we wished to understand the nature of the genomic alterations which correlated with the loss of this ability. as a first step, the heterogeneity of dna molecules in the p3j-hr-1 line was eliminated by cell cloning. then a physical map was prepared of virion dna from one cell clone, designated ff452-3. by comparison with the genomes of two ebvs, b95-8 and ff41, which are competent to immortalize lymphocytes, w ... | 1982 | 6294333 |
| identification and characterization of a dnase induced by epstein-barr virus. | the diterpene ester promoter of mouse skin tumors, 12-o-tetradecanoyl-phorbol-13-acetate, induced a dnase activity in the epstein-barr virus-producer cell line p3hr-1. the elution patterns of the enzyme from deae-cellulose, phosphocellulose, and dna-cellulose columns were different from virus-associated dna polymerase activity. the partially purified activity could be neutralized to the extent of 90% by sera of patients with nasopharyngeal carcinoma. purified immunoglobulin g from sera of nasoph ... | 1982 | 6294337 |
| [infectious mononucleosis]. | 1982 | 6294511 | |
| infectious mononucleosis: observations on transmission. | epsten-barr virus oropharyngeal shedding has been demonstrated in infectious mononucleosis patients many months after acute illness and long after the disease hallmarks, atypical lymphocytes and heterophile antibody, have disappeared. extracellular virus is present more frequently in saliva than in other oropharyngeal samples. prolonged excretion of ebv in asymptomatic carriers explains the difficulty in tracing case-to-case spread and increased transmissibility in age groups in which salivary e ... | 1982 | 6295004 |
| prospects for human monoclonal antibodies: a critical perspective. | 1982 | 6295006 | |
| immortalization of human lymphocytes by epstein-barr virus. | epstein-barr virus (ebv) confers upon normal lymphocytes derived from bone marrow the ability to proliferate indefinitely in a test tube. this process, called immortalization, is crucial to the pathogenesis of ebv infections. inside the immortalized lymphocyte the ebv genome exists as a complete multicopy circular plasmid which is probably not integrated into the cell chromosome. most of the viral genetic information is not expressed. however, at least six to eight separate regions of the ebv ge ... | 1982 | 6295007 |
| the biology of circulating b lymphocytes infected with epstein-barr virus during infectious mononucleosis. | ebv-infected b cells are present in blood during acute infectious mononucleosis (im) in surprisingly large numbers. these cells share with cells transformed by ebv in vitro the capacity for unlimited proliferation, but this capacity is quite restricted in the normal host. the unusual extent of plasmacytic differentiation seen in infected cells in vivo early in im and the loss of this differentiation in the late stages of the disease suggest that these cells are subject to the same immunoregulato ... | 1982 | 6295008 |
| the functions of a university-based viral diagnostic laboratory: recent experiences at yale-new haven hospital. | 1982 | 6295010 | |
| induction and abrogation of suppressor cell function in humans: effect on b cell activation by different polyclonal activators. | in a reverse plaque forming cell (pfc) assay, the effect of concanavalin a (con-a)-induced suppressor cells on polyclonally activated b lymphocytes was studied. differentiation to pfc, as induced by pokeweed mitogen (pwm), staphylococcus aureus or epstein-barr virus (ebv) was in all cases suppressed by the addition of cona-pretreated cells. the ebv-stimulated cells showed the smallest pfc response and appeared least amenable to suppression. iga-secreting cells were less suppressible than igm- an ... | 1982 | 6295061 |
| [the epstein-barr virus and tonsilar carcinoma in clinical practice]. | 1982 | 6295630 | |
| [inhibitory effect of retinoids on epstein-barr virus induction in raji cells]. | 1982 | 6295650 | |
| [detection of early npc from vca/iga antibody positive individuals with anticomplement immunoenzymatic method]. | 1982 | 6295651 | |
| antibodies to eb virus- and cytomegalovirus-induced antigens in early rheumatoid disease. | 1982 | 6295670 | |
| interaction of epstein-barr virus with leukaemic b cells in vitro. i. abortive infection and rare cell line establishment from chronic lymphocytic leukaemic cells. | leukaemia b cell populations, each with an individual pattern of monoclonal surface immunoglobulin expression, were obtained from 23 patients with chronic lymphocytic leukaemia (cll) and, following exposure to a potent dose of epstein-barr (eb) virus in vitro, were monitored for expression of the virus associated nuclear antigen ebna, for activation of immunoglobulin synthesis and for virus-induced transformation to an established cell line. although possessing the eb virus receptor, cll cells w ... | 1982 | 6295671 |
| immunologic aspects of melanoma. | 1982 | 6295700 | |
| immunopathogenesis of rheumatoid arthritis. | three distinct groups of phenomena occur in the rheumatoid joint. the synovial lining cells proliferate and hypertrophy; the sublining or deep layer becomes infiltrated by mononuclear cells; and fluid, which is rich in polymorphonuclear cells, collects in the synovial space. as a result, there is a polymorphonuclear inflammatory reaction in the rheumatoid effusion and a chronic inflammatory reaction in the sublining layer of synovial membrane. in spite of their divergent histologic character, th ... | 1982 | 6295771 |
| antibody responses to epstein-barr virus-specific dnase in relation to the prognosis of juvenile patients with nasopharyngeal carcinoma. | we have examined serial sera from 17 juvenile patients with nasopharyngeal carcinoma (npc) for their capacity to neutralize the activity of epstein-barr virus (ebv)-specific dnase. the results revealed that npc patients who became long-term survivors (lts) without evidence of the disease either never possessed significant levels of antibodies to the enzyme or showed a gradual decline in the number of ebv dnase units neutralized from an elevated level at diagnosis to an insignificant figure sever ... | 1982 | 6295964 |
| discordant epstein-barr virus nuclear antigen (ebna) antibody patterns in nasopharyngeal carcinoma. | epstein-barr virus nuclear antigen (ebna) preparations from three sources were tested with sera from normal individuals and patients with hodgkin's disease, breast carcinoma, burkitt's lymphoma, and american and chinese nasopharyngeal carcinoma. individual sera with discordant antibody patterns were noted in all groups. sera from both npc groups gave significantly higher anti-ebna titers on cell lines converted with p3hr-1 or b95-8 virus compared with anti-ebna titers on raji cells. anti-ebna ti ... | 1982 | 6295966 |