Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| synergistic mutual potentiation of antifungal activity of zuccagnia punctata cav. and larrea nitida cav. extracts in clinical isolates of candida albicans and candida glabrata. | zuccagnia punctata cav. (fabaceae) and larrea nitida cav. (zygophyllaceae) are indistinctly or jointly used in traditional medicine for the treatment of fungal-related infections. although their dichloromethane (dcm) extract have demonstrated moderate antifungal activities when tested on their own, antifungal properties of combinations of both plants have not been assessed previously. | 2015 | 26055132 |
| deletion of the dna ligase iv gene in candida glabrata significantly increases gene-targeting efficiency. | candida glabrata is reported as the second most prevalent human opportunistic fungal pathogen in the united states. over the last decades, its incidence increased, whereas that of candida albicans decreased slightly. one of the main reasons for this shift is attributed to the inherent tolerance of c. glabrata toward the commonly used azole antifungal drugs. despite a close phylogenetic distance to saccharomyces cerevisiae, homologous recombination works with poor efficiency in c. glabrata compar ... | 2015 | 26048009 |
| biosynthesis of silver nanoparticles and its antibacterial and antifungal activities towards gram-positive, gram-negative bacterial strains and different species of candida fungus. | biomimetic and economic method for the synthesis of silver nanoparticles (agnps) with controlled size has been reported in presence of shape-directing cetlytrimethylammonium bromide (ctab). biochemical reduction of ag(+) ions in micellar solution with an aqueous lemon extract produced spherical and polyhedral agnps with size ranging from 15 to 30 nm. the influence of [ctab] and [lemon extract] on the size of particles, fraction of metallic silver and their antimicrobial properties is discussed. ... | 2015 | 26017756 |
| next-generation sequencing offers new insights into the resistance of candida spp. to echinocandins and azoles. | mdr candida strains are emerging. next-generation sequencing (ngs), which enables extensive and deep genome analysis, was used to investigate echinocandin and azole resistance in clinical candida isolates. | 2015 | 26017039 |
| synergistic antifungal activity of berberine derivative b-7b and fluconazole. | our previous study demonstrated berberine (bbr) and fluconazole (flc) used concomitantly exhibited a synergism against flc-resistant candida albicans in vitro. we also suggested bbr played a major antifungal role in the synergism of flc and bbr, while flc increased intracellular bbr concentrations. our following systematic structural modification and reconstruction of bbr core identified the novel scaffold of n-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-2-(substituted phenyl)acet-amide derivatives 7a-i ... | 2015 | 25992630 |
| isavuconazole, micafungin, and 8 comparator antifungal agents' susceptibility profiles for common and uncommon opportunistic fungi collected in 2013: temporal analysis of antifungal drug resistance using clsi species-specific clinical breakpoints and proposed epidemiological cutoff values. | the in vitro activities of isavuconazole, micafungin, and 8 comparator antifungal agents were determined for 1613 clinical isolates of fungi (1320 isolates of candida spp., 155 of aspergillus spp., 103 of non-candida yeasts, and 35 non-aspergillus molds) collected during a global survey conducted in 2013. the vast majority of the isolates of the 21 different species of candida, with the exception of candida glabrata (mic90, 2 μg/ml), candida krusei (mic90, 1 μg/ml), and candida guilliermondii (m ... | 2015 | 25986029 |
| decrease in ribosomal rna in candida albicans induced by serum exposure. | candida albicans is an important polymorphic human pathogen. it can switch from a unicellular yeast form to germinating hypha, which may play a role in making it the successful pathogen it is. this hyphal transformation can be triggered by various extracellular stimuli, the most potent one being serum from any source. we have previously reported that candida albicans transiently polyadenylates portions of both the large and small subunits of ribosomal rna, shortly after serum exposure. northern ... | 2015 | 25946110 |
| development of gendine-coated cannula for continuous subcutaneous insulin infusion for extended use. | continuous subcutaneous insulin infusion (csii) using pumps is a widely used method for insulin therapy in patients with diabetes mellitus. among the major factors that usually lead to the discontinuation of csii are csii set-related issues, including infection at the infusion site. the american diabetic association currently recommends rotating sites every 2 to 3 days. this recommendation adds cost and creates inconvenience. therefore, in order to prevent infections and extend the duration betw ... | 2015 | 25941227 |
| urinary tract infections and candida albicans. | urinary tract candidiasis is known as the most frequent nosocomial fungal infection worldwide. candida albicans is the most common cause of nosocomial fungal urinary tract infections; however, a rapid change in the distribution of candida species is undergoing. simultaneously, the increase of urinary tract candidiasis has led to the appearance of antifungal resistant candida species. in this review, we have an in depth look into candida albicans uropathogenesis and distribution of the three most ... | 2015 | 25914847 |
| candida survival strategies. | only few candida species, e.g., candida albicans, candida glabrata, candida dubliniensis, and candida parapsilosis, are successful colonizers of a human host. under certain circumstances these species can cause infections ranging from superficial to life-threatening disseminated candidiasis. the success of c. albicans, the most prevalent and best studied candida species, as both commensal and human pathogen depends on its genetic, biochemical, and morphological flexibility which facilitates adap ... | 2015 | 25911234 |
| candida biomarkers in patients with candidaemia and bacteraemia. | microbiological strategies are necessary to help clinicians discontinue empirical antifungal therapy in patients with suspected invasive candidiasis. culture methods and biomarkers each show low sensitivity. we analysed the value of combining different biomarkers as a decision-making tool for discontinuing empirical antifungal treatment. | 2015 | 25900160 |
| antifungal susceptibility profiles of bloodstream yeast isolates by sensititre yeastone over nine years at a large italian teaching hospital. | sensititre yeastone (syo) is an affordable alternative to the clinical and laboratory standards institute (clsi) reference method for antifungal susceptibility testing. in this study, the mics of yeast isolates from 1,214 bloodstream infection episodes, generated by syo during hospital laboratory activity (january 2005 to december 2013), were reanalyzed using current clsi clinical breakpoints/epidemiological cutoff values to assign susceptibility (or the wild-type [wt] phenotype) to systemic ant ... | 2015 | 25896705 |
| epidemiology of oropharyngeal candidiasis in human immunodeficiency virus/acquired immune deficiency syndrome patients and cd4+ counts. | the present study was directed to evaluate the forms of oropharyngeal candidiasis (opc) and their correlation with cd4+ cell counts in human immunodeficiency virus (hiv) patients. | 2015 | 25878473 |
| neutrophil activation by candida glabrata but not candida albicans promotes fungal uptake by monocytes. | candida albicans and candida glabrata account for the majority of candidiasis cases worldwide. although both species are in the same genus, they differ in key virulence attributes. within this work, live cell imaging was used to examine the dynamics of neutrophil activation after confrontation with either c. albicans or c. glabrata. analyses revealed higher phagocytosis rates of c. albicans than c. glabrata that resulted in stronger pmn (polymorphonuclear cells) activation by c. albicans. furthe ... | 2015 | 25850517 |
| in vitro and in vivo antimicrobial evaluation of alkaloidal extracts of enantia chlorantha stem bark and their formulated ointments. | the in vitro and in vivo antimicrobial evaluation of the formulated ointment of alkaloidal extract of enantia chlorantha oliv. (annonaceae) was the concern of this study. the alkaloidal fraction of the stem bark extract was formulated into simple ointment using british pharmacopoeia formula for preparation of simple ointment. agar diffusion and agar dilution methods were used for the in vitro antimicrobial studies. ketoconazole 4000 μg/ml and tioconazole cream 1% were used as reference standards ... | 2015 | 25850210 |
| posttreatment antifungal resistance among colonizing candida isolates in candidemia patients: results from a systematic multicenter study. | the prevalence of intrinsic and acquired resistance among colonizing candida isolates from patients after candidemia was investigated systematically in a 1-year nationwide study. patients were treated at the discretion of the treating physician. oral swabs were obtained after treatment. species distributions and mic data were investigated for blood and posttreatment oral isolates from patients exposed to either azoles or echinocandins for <7 or ≥ 7 days. species identification was confirmed usin ... | 2015 | 26711776 |
| evaluation of chromogenic agar, [corrected] vitek2 yst and vitek® ms for identification of candida strains isolated from blood cultures. | the aim of this study is to compare conventional methods, chromogenic agar, [corrected] vitek2 yst card and vitek®ms system for the identification of candida strains isolated from blood cultures. fifty-four strains were identified according to conventional methods, chromogenic agar, [corrected] vitek2 yst card and vitek®ms. sequencing was used as the reference method. the 54 strains included 32 candida parapsilosis, 19 candida albicans, 1 candida glabrata and 2 candida tropicalis according to th ... | 2015 | 26700081 |
| assessment of echinocandin regimens by pharmacokinetic/pharmacodynamic analysis against candida spp. in paediatric patients. | this study aimed to investigate the cumulative fraction of response of various echinocandin (caspofungin, micafungin and anidulafungin) dosing regimens against candida spp. in paediatric patients with invasive fungal infections (ifis). monte carlo simulations were performed using previously published pharmacokinetic parameters and pharmacodynamic data to evaluate the ability of each echinocandin regimen in terms of fauc/mic (free drug area under the concentration-time curve/minimum inhibition co ... | 2015 | 26602452 |
| study of clinical spectrum and risk factors of neonatal candidemia. | candida colonization in neonates results in significant morbidity and mortality. the prevalence and clinical significance of neonatal candidemia are poorly understood. | 2015 | 26549069 |
| clinical perspectives on echinocandin resistance among candida species. | we review and offer our clinical perspectives on the emergence of echinocandin-resistant candida. | 2015 | 26524326 |
| antimicrobial potential of 27 plants consumed by chimpanzees (pan troglodytes verus blumenbach) in ivory coast. | due to their genetic proximity, chimpanzees share with human several diseases including bacterial, fungal and viral infections, such as candidiasis, acquired immune deficiency syndrome (aids), ebola virus disease. however, in its natural environment, chimpanzees are tolerant to several pathogens including simian immunodeficiency virus (siv), virus related to human immunodeficiency virus (hiv) that contribute to the emergence of opportunistic diseases such as microbial infections. | 2015 | 26498034 |
| efficient mating-type switching in candida glabrata induces cell death. | candida glabrata is an apparently asexual haploid yeast that is phylogenetically closer to saccharomyces cerevisiae than to candida albicans. its genome contains three mat-like cassettes, mat, which encodes either mata or matalpha information in different strains, and the additional loci, hml and hmr. the genome also contains an ho gene homolog, but this yeast has never been shown to switch mating-types spontaneously, as s. cerevisiae does. we have recently sequenced the genomes of the five spec ... | 2015 | 26491872 |
| inherited card9 deficiency in otherwise healthy children and adults with candida species-induced meningoencephalitis, colitis, or both. | invasive infections of the central nervous system (cns) or digestive tract caused by commensal fungi of the genus candida are rare and life-threatening. the known risk factors include acquired and inherited immunodeficiencies, with patients often displaying a history of multiple infections. cases of meningoencephalitis, colitis, or both caused by candida species remain unexplained. | 2015 | 25702837 |
| probiotic lactobacillus rhamnosus gr-1 and lactobacillus reuteri rc-14 exhibit strong antifungal effects against vulvovaginal candidiasis-causing candida glabrata isolates. | this study investigates the antagonistic effects of the probiotic strains lactobacillus rhamnosus gr-1 and lactobacillus reuteri rc-14 against vulvovaginal candidiasis (vvc)-causing candida glabrata. | 2015 | 25688886 |
| synthesis, qsar and anticandidal evaluation of 1,2,3-triazoles derived from naturally bioactive scaffolds. | in the present study, we used eight natural precursors (1a-h) with most of them having promising antimicrobial activities and synthesised their novel 1,2,3-triazole derivatives (3a-h). in the reaction sequences, the precursor compounds (1a-h) were converted to their respective alkyne (2a-h) followed by addition of benzyl azide freshly prepared by the reaction of benzyl bromide with sodium azide using [3 + 2] azide-alkyne cycloaddition strategy. structural elucidation of all the triazole derivati ... | 2015 | 25686593 |
| the effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of candida species induced biofilms. | biofilm formation is often associated with increased candida resistance toward antifungal agents. therefore, the current study aimed to assess the incidence of biofilm formation among candida isolates and to investigate the effect of high doses of fluconazole {flc}, voriconazole {voc} and amphotericin b {amb}, singly and in combination on mature biofilms. moreover, it aimed to assess the expression of selected genes (cdr1, kre1 and skn1) responsible for candida biofilm resistance. the study incl ... | 2015 | 25685044 |
| patterns of candida biofilm on intrauterine devices. | biofilms are colonies of microbial cells encased in a self-produced organic polymeric matrix and represent a common mode of microbial growth. microbes growing as biofilm are highly resistant to commonly used antimicrobial drugs. we aimed to screen and characterize biofilm formation by different isolates of candida on removed intrauterine devices (iuds), to perform experimental biofilm formation with isolated strains, and to examine biofilm by the crystal violet and xtt reduction assays and scann ... | 2015 | 25681320 |
| site-specific mesenchymal control of inflammatory pain to yeast challenge in vulvodynia-afflicted and pain-free women. | fibroblast strains were derived from 2 regions of the lower genital tract of localized provoked vulvodynia (lpv) cases and pain-free controls. sixteen strains were derived from 4 cases and 4 controls, age and race matched, after presampling mechanical pain threshold assessments. strains were challenged with 6 separate stimuli: live yeast species (candida albicans, candida glabrata, candida tropicalis, and saccharomyces cerevisiae), yeast extract (zymosan), or inactive vehicle. production of pros ... | 2015 | 25679469 |
| design of micelle nanocontainers based on pdmaema-b-pcl-b-pdmaema triblock copolymers for the encapsulation of amphotericin b. | the clinical application of amphotericin b (amb), a broad spectrum antifungal agent, is limited by its poor solubility in aqueous medium and also by its proven renal toxicity. in this work, amb was encapsulated in micelles obtained from the self-assembly of pdmaema-b-pcl-b-pdmaema triblock copolymers. the amount of encapsulated amb depended on the copolymer composition, and short blocks of polycaprolactone (pcl) and poly(2-dimethylaminoethyl methacrylate) (pdmaema) showed better performance. all ... | 2015 | 25669917 |
| current methods for identifying clinically important cryptic candida species. | in recent years, the taxonomy of the most important pathogenic candida species (candida albicans, candida parapsilosis and candida glabrata) has undergone profound changes due to the description of new closely-related species. this has resulted in the establishment of cryptic species complexes difficult to recognize in clinical diagnostic laboratories. the identification of these novel candida species seems to be clinically relevant because it is likely that they differ in virulence and drug res ... | 2015 | 25659326 |
| susceptibility characterisation of candida spp. to four essential oils. | in the present investigation, anti-candida activity of four essential oils i.e. black cumin (nigella sativa), curry leaf (murraya koienigii), ajwain (trachiyspirum ammi), and betel leaf (piper betel) were screened against four human pathogenic species of candida viz. candida albicans, candida tropicalis, candida glabrata, and candida parapsilosis. the minimum inhibitory concentration (mic) values of the oils ranged between 15.62 and 250 μl/ml while studied through tube dilution method. the oils ... | 2015 | 25657164 |
| invasive candida infections in surgical patients in intensive care units: a prospective, multicentre survey initiated by the european confederation of medical mycology (ecmm) (2006-2008). | a prospective, observational, multicentre study of invasive candidosis (ic) in surgical patients in intensive care units (icus) was conducted from 2006 to 2008 in 72 icus in 14 european countries. a total of 779 patients (62.5% males, median age 63 years) with ic were included. the median rate of candidaemia was 9 per 1000 admissions. in 10.8% the infection was already present at the time of admission to icu. candida albicans accounted for 54% of the isolates, followed by candida parapsilosis 18 ... | 2015 | 25636940 |
| analysis of the essentiality of rom2 genes in the pathogenic yeasts candida glabrata and candida albicans using temperature-sensitive mutants. | to analyse the essentiality of the rom2 genes originating from the pathogenic yeasts candida glabrata and candida albicans by using temperature-sensitive (ts) mutants. | 2015 | 25604069 |
| candida albicans opi1 regulates filamentous growth and virulence in vaginal infections, but not inositol biosynthesis. | scopi1p is a well-characterized transcriptional repressor and master regulator of inositol and phospholipid biosynthetic genes in the baker's yeast saccharomyces cerevisiae. an ortholog has been shown to perform a similar function in the pathogenic fungus candida glabrata, but with the distinction that cgopi1p is essential for growth in this organism. however, in the more distantly related yeast yarrowia lipolytica, the opi1 homolog was not found to regulate inositol biosynthesis, but alkane oxi ... | 2015 | 25602740 |
| in vitro activity of a hos2 deacetylase inhibitor, mgcd290, in combination with echinocandins against echinocandin-resistant candida species. | mgcd290, a hos2 fungal histone deacetylase inhibitor, showed modest activity when tested alone (mic range, 0.12-4 μg/ml; mic50/90, 0.5/4 μg/ml) against candida glabrata (n=15; 14 fks mutants; 5 also fluconazole resistant), candida albicans (8 fks mutants; 2 also fluconazole resistant), candida tropicalis (4 fks mutants), and candida krusei (3 fks mutants). however, mgcd290 showed synergy or partial synergy for 33.3%, 30.1%, 36.7%, and 80.0% of the isolates when tested with anidulafungin, caspofu ... | 2015 | 25600842 |
| molecular identification and antifungal susceptibility of 186 candida isolates from vulvovaginal candidiasis in southern china. | there is limited information regarding the molecular epidemiology and antifungal susceptibilities of candida isolates using the neo-sensitabs method in patients with vulvovaginal candidiasis (vvc). from august 2012 to march 2013, 301 non-pregnant patients aged 18-50 years with suspected vvc were prospectively screened at a teaching hospital in southern china. the vaginal isolates were identified by dna sequencing of internal transcribed spacer and the d1/d2 domain. antifungal susceptibility test ... | 2015 | 25596116 |
| t2 magnetic resonance assay for the rapid diagnosis of candidemia in whole blood: a clinical trial. | microbiologic cultures, the current gold standard diagnostic method for invasive candida infections, have low specificity and take up to 2-5 days to grow. we present the results of the first extensive multicenter clinical trial of a new nanodiagnostic approach, t2 magnetic resonance (t2mr), for diagnosis of candidemia. | 2015 | 25586686 |
| defining the transcriptomic landscape of candida glabrata by rna-seq. | candida glabrata is the second most common pathogenic candida species and has emerged as a leading cause of nosocomial fungal infections. its reduced susceptibility to antifungal drugs and its close relationship to saccharomyces cerevisiae make it an interesting research focus. although its genome sequence was published in 2004, little is known about its transcriptional dynamics. here, we provide a detailed rna-seq-based analysis of the transcriptomic landscape of c. glabrata in nutrient-rich me ... | 2015 | 25586221 |
| chemical composition and antimicrobial evaluation of the essential oils of bocageopsis pleiosperma maas. | essential oils from the leaves, twigs and barks of bocageopsis pleiosperma maas were obtained by using hydrodistillation and analysed by using gas chromatography coupled to mass spectrometry. several compounds (51) were detected and identified, being β-bisabolene the main component in all aerial parts of the plant, with higher concentration in the leaves (55.77%), followed by barks (38.53%) and twigs (34.37%). in order to increase the biological knowledge about the essential oil of bocageopsis s ... | 2015 | 25562370 |
| [yeast species in vulvovaginitis candidosa]. | vulvovaginal candidiasis is the most common mycosis, however, the available information about antifungal susceptibilities of these yeasts is limited. | 2015 | 25544052 |
| [onychomycosis by yeast not common in diabetics of a health center]. | mexican diabetic population frequently presents mycosis under foot hyperkeratosis; however, in another type of onychomycosis as the ones that is assumed candida albicans is the causal agent, it is unknown the frequency, the prevalence and if another candida species or other yeasts are found. | 2016 | 26482238 |
| microbiota-gut-brain axis: yeast species isolated from stool samples of children with suspected or diagnosed autism spectrum disorders and in vitro susceptibility against nystatin and fluconazole. | autism spectrum disorder (asd) is a general term for a group of complex neurodevelopmental disorders of brain development that limits a person's ability to function normally. etiology has not been clearly defined up to date. however, gut microbiota and the bidirectional communication between the gastrointestinal tract and brain, the so-called microbiota-gut-brain axis, are hypothesized, which may be involved in the etiology of several mental disorders. recent reports suggest that candida, partic ... | 2016 | 26442855 |
| [first report of invasive fungal disease by candida fabianii in a non-neonatal paediatric patient]. | invasive fungal diseases have increased in recent years. candida species are the most common aetiology. candida albicans, candida parapsilosis, candida tropicalis, candida glabrata and candida krusei are the cause of most of them. the aim of this work is to describe the first isolation of candida fabianii in the blood of a non-neonatal paediatric patient. | 2016 | 26439426 |
| detection of candida spp. in the vagina of a cohort of nulliparous pregnant women by culture and molecular methods: is there an association between maternal vaginal and infant oral colonisation? | most studies describing vaginal candida spp. in pregnancy focus on symptomatic vaginitis, rather than asymptomatic colonisation, and solely utilise microbiological culture. the extent to which asymptomatic vaginal carriage may represent a reservoir for infant oral colonisation has been highly debated. | 2016 | 26437337 |
| biofilm formation is a risk factor for mortality in patients with candida albicans bloodstream infection-scotland, 2012-2013. | bloodstream infections caused by candida species remain a significant cause of morbidity and mortality in hospitalized patients. biofilm formation by candida species is an important virulence factor for disease pathogenesis. a prospective analysis of patients with candida bloodstream infection (n = 217) in scotland (2012-2013) was performed to assess the risk factors associated with patient mortality, in particular the impact of biofilm formation. candida bloodstream isolates (n = 280) and clini ... | 2016 | 26432192 |
| typing candida species using microsatellite length polymorphism and multilocus sequence typing. | to gain more insight into the epidemiological relationships between isolates of candida spp. obtained from various origins, several molecular typing techniques have been developed. two methods have emerged in the 2000s as soon as enough knowledge of the candida spp. genomes was available to choose adequate loci and primers, namely microsatellite length polymorphism (mlp) and multilocus sequence typing (mlst). to contrast with previous pcr-based methods, specific amplifications with stringent con ... | 2016 | 26519075 |
| impact of antifungal prescription on relative distribution and susceptibility of candida spp. - trends over 10 years. | the incidence of candida spp. infections is worrisome, particularly in critically ill patients. previous reports suggested that increasing use of antifungal therapy might affect resistance profiles of invasive strains. the study objective was to describe the distribution resistance profile of candida spp. strains, and to correlate it with antifungal consumptions within one icu. | 2016 | 26518058 |
| membrane proteome-wide response to the antifungal drug clotrimazole in candida glabrata: role of the transcription factor cgpdr1 and the drug:h+ antiporters cgtpo1_1 and cgtpo1_2. | azoles are widely used antifungal drugs. this family of compounds includes triazoles, mostly used in the treatment of systemic infections, and imidazoles, such as clotrimazole, often used in the case of superficial infections. candida glabrata is the second most common cause of candidemia worldwide and presents higher levels of intrinsic azole resistance when compared with candida albicans, thus being an interesting subject for the study of azole resistance mechanisms in fungal pathogens.since r ... | 2016 | 26512119 |
| [isolated yeast species in urine samples in a spanish regional hospital]. | candiduria detection in hospitalized or immunocompromised patients is of great clinical significance. the aim of our study was to describe the isolation frequency of significant species of yeasts in urine samples processed in our hospital during the period 2010- 2013, and to analyze their susceptibility to commonly used antifungal agents. species identification was performed by seeding on a chromogenic medium, the filamentation test and automated systems (asm vitek and maldi biotyper), while sus ... | 2016 | 26507634 |
| yeasts associated with culex pipiens and culex theileri mosquito larvae and the effect of selected yeast strains on the ontogeny of culex pipiens. | the success of mosquitoes in nature has been linked to their microbiota and bacteria in particular. yet, knowledge on their symbioses with yeasts is lacking. to explore possible associations, culturable yeasts were isolated from wild larvae of culex pipiens and culex theileri. these yeasts were classified using restriction fragment length polymorphism (rflp) analyses and identified by sequencing the d1/d2 region of the 26s rrna gene. representative strains of candida, cryptococcus, galactomyces, ... | 2016 | 26573833 |
| a comparative investigation of azole susceptibility in candida isolates from vulvovaginal candidiasis and recurrent vulvovaginal candidiasis patients in ghana. | vulvovaginal candidiasis (vvc) and recurrent vulvovaginal candidiasis (rvvc) affect millions of women and are typically treated with azoles. we know little about azole susceptibility of candida species from vvc versus rvvc patients, and nothing about african isolates. we have investigated the susceptibility of candida isolates from ghana to fluconazole, itraconazole and/or voriconazole. the percentage of candida albicans isolates showing susceptibility was significantly lower in rvvc than vvc pa ... | 2016 | 27838642 |
| vulvovaginal candidiasis: epidemiology, microbiology and risk factors. | vulvovaginal candidiasis (vvc) is an infection caused by candida species that affects millions of women every year. although candida albicans is the main cause of vvc, the identification of non-candida albicans candida (ncac) species, especially candida glabrata, as the cause of this infection, appears to be increasing. the development of vvc is usually attributed to the disturbance of the balance between candida vaginal colonization and host environment by physiological or nonphysiological chan ... | 2016 | 26690853 |
| biofilm formation in candida glabrata: what have we learnt from functional genomics approaches? | biofilms are a source of therapeutic failures because of their intrinsic tolerance to antimicrobials. candida glabrata is one of the pathogenic yeasts that is responsible for life-threatening disseminated infections and able to form biofilms on medical devices such as vascular and urinary catheters. recent progresses in the functional genomics of c. glabrata have been applied to the study of biofilm formation, revealing the contribution of an array of genes to this process. in particular, the ya ... | 2016 | 26678748 |
| antifungal susceptibilities of candida species isolated from the patients with vaginal candidiasis. | there have been the current japanese data on susceptibility testing for candida isolates from vaginal candidiasis. the in vitro activities of therapeutic antifungal drugs for vulvovaginal candidiasis (vvc); miconazole (mcz), itraconazole (itcz), fluconazole (flcz), clotrimazole (ctz), oxiconazole (ocz), isoconazole (icz) and bifonazole (bfz) against vaginal isolates. fifty-four strains candida albicans and 19 strains of candida glabrata were evaluated using a broth microdilution method specified ... | 2016 | 26627336 |
| caspofungin mic distribution amongst commonly isolated candida species in a tertiary care centre - an indian experience. | emergence of candida species resistant to amphotericin b and triazole has led to use of echinocandins, mostly caspofungin in the management of invasive candidiasis. there are some published reports of caspofungin resistance in candida species yet no studies on caspofungin susceptibility pattern of candida species exist in indian setup. | 2016 | 28050365 |
| activity of the aqueous extract of schinus terebinthifolius raddi on strains of the candida genus. | objectives to evaluate the antifungal susceptibility profile of the aqueous extract of the bark of schinus terebinthifolius raddi against the strains of the genus candida. methods by using the disk diffusion method, 50 samples of the genus candida (candida albicans; candida krusei; candida glabrata; and candida tropicalis), isolated from patients receiving treatment at hospital santa casa de misericórdia de são paulo, and 1 american type culture collection (atcc) sample of each species were test ... | 2016 | 28038478 |
| candida species isolated from different body sites and their antifungal susceptibility pattern: cross-analysis of candida albicans and candida glabrata biofilms. | candida species are regular commensal in humans, but-especially in immunocompromised patients-they represent opportunistic pathogens giving rise to systemic infection. the aim of the present work was to isolate and characterize for their antifungal profile candida species from different body sites and to analyze the biofilms produced by c. albicans and c. glabrata isolates. eighty-one strains of candida species from 77 patients were identified. epidemiological study showed that the most isolated ... | 2016 | 27915303 |
| the current treatment landscape: candidiasis. | the epidemiology of candida species infection has changed over recent decades, influenced by local hospital-related factors, patient predisposing conditions and type of antifungal agents administered. a shift from candida albicans as the predominant pathogen towards an increasing prevalence of the species candida glabrata and candida parapsilosis amongst critically ill patients has been documented. changes in candida species distribution may impact treatment recommendations due to differences in ... | 2016 | 27880665 |
| miltefosine inhibits candida albicans and non-albicans candida spp. biofilms and impairs the dispersion of infectious cells. | candida spp. can adhere to and form biofilms over different surfaces, becoming less susceptible to antifungal treatment. resistance of biofilms to antifungal agents is multifactorial and the extracellular matrix (ecm) appears to play an important role. among the few available antifungals for treatment of candidaemia, only the lipid formulations of amphotericin b (amb) and the echinocandins are effective against biofilms. our group has previously demonstrated that miltefosine has an important eff ... | 2016 | 27667564 |
| anti-candida activity assessment of pelargonium graveolens oil free and nanoemulsion in biofilm formation in hospital medical supplies. | infections due to microbial biofilm formation on the surface of catheters and other medical devices are constantly reported as a major cause of morbidity and mortality in patients admitted to hospitals. furthermore, sessile cells are more resistant to phagocytosis and most antimicrobial, which complicates the treatment of such infections. researches aimed at new antimicrobial originating mainly from plants have increased in recent years and the development of new strategies for their release is ... | 2016 | 27544324 |
| ureaplasma parvum genotype, combined vaginal colonisation with candida albicans, and spontaneous preterm birth in an australian cohort of pregnant women. | detection of ureaplasma, mycoplasma and candida spp. in the vagina during pregnancy has previously been associated with preterm birth (ptb). however, the prevalence of these microorganisms and the associated obstetric risks (likely to be population-specific) have not been determined in australian women; furthermore, in the case of ureaplasma spp., very few studies have attempted characterisation at the species level and none have examined genotype/serovar status to further refine risk assessment ... | 2016 | 27756249 |
| [epidemiology, risk factors and in vitro susceptibility in candidaemia due to non-candida albicans species]. | invasive fungal infection (ifi) has increased in recent years due to there being a greater number of risk factors. ifi caused by candida is the most frequent, and although candida albicans is the most isolated species, there is currently a decrease of c. albicans and an increase of other species of the genus. | 2016 | 27746090 |
| fungal infections in patients with walled-off pancreatic necrosis. | this study aimed to evaluate the influence of fungal infection and antifungal treatment on outcome in patients with walled-off pancreatic necrosis (won). | 2016 | 27518465 |
| sequence-identification of candida species isolated from candidemia. | candida species are the most prevalent cause of invasive fungal infections such as candidemia. candidemia is a lethal fungal infection among immunocompromised patients worldwide. main pathogen is candida albicans but a global shift in epidemiology toward non-albicans species have reported. species identification is imperative for good management of candidemia as a fatal infection. the aim of the study is to identify candida spp. obtained from candidemia and determination of mortality rate among ... | 2016 | 27713871 |
| the epidemiology and outcomes of invasive candida infections among organ transplant recipients in the united states: results of the transplant-associated infection surveillance network (transnet). | invasive candidiasis (ic) is a common cause of mortality in solid organ transplant recipients (otrs), but knowledge of epidemiology in this population is limited. | 2016 | 27643395 |
| candida species diversity and antifungal susceptibility patterns in oral samples of hiv/aids patients in baja california, mexico. | candidiasis is the most common opportunistic fungal infection in hiv patients. the aims of this study were to identify the prevalence of carriers of candida, candida species diversity, and in vitro susceptibility to antifungal drugs. in 297 hiv/aids patients in baja california, mexico, candida strains were identified by molecular methods (pcr-rflp) from isolates of oral rinses of patients in tijuana, mexicali, and ensenada. 56.3% of patients were colonized or infected with candida in tijuana, th ... | 2016 | 27630251 |
| effect of mechanical toothbrushing combined with different denture cleansers in reducing the viability of a multispecies biofilm on acrylic resins. | to investigate the efficacy of immersion and brushing with different cleansing agents in reducing the viability of multispecies biofilm on acrylic resins. | 2016 | 27505992 |
| evaluation of antifungal activity of standardized extract of salvia rhytidea benth. (lamiaceae) against various candida isolates. | salvia species have long been described in traditional medicine for various indications. owing to the widespread use of this genus by ethnic populations, especially for various infections ranging from skin disease to gastrointestinal disorders, we were encouraged to determine whether salvia rhytidea could be effective against fungal infections. given the increased incidence of candidiasis in the past decade, limits on the use of antifungal drugs, emergence of azole-resistant candida species and ... | 2016 | 27499461 |
| bortezomib inhibits bacterial and fungal β-carbonic anhydrases. | inhibition of the β-carbonic anhydrases (cas, ec 4.2.1.1) from pathogenic fungi (cryptococcus neoformans, candida albicans, candida glabrata, malassezia globosa) and bacteria (three isoforms from mycobacterium tuberculosis, rv3273, rv1284 and rv3588), as well from the insect drosophila melanogaster (dmeca) and the plant flaveria bidentis (fbica1) with the boronic acid peptidomimetic proteosome inhibitor bortezomib was investigated. bortezomib was a micromolar inhibitor of all these enzymes, with ... | 2016 | 27469982 |
| antifungal potential of eugenyl acetate against clinical isolates of candida species. | the study evaluated the efficiency of eugenyl acetate (ea), a phytochemical in clove essential oil, against clinical isolates of candida albicans, candida parapsilosis, candida tropicalis, and candida glabrata. minimum inhibitory concentrations (mic) of ea against candida isolates were in the range between 0.1% and 0.4% (v/v). spot assay further confirmed the susceptibility of candida isolates to the compound upon treatment with respective 1 × mic. growth profile measured in time kill study evid ... | 2016 | 27452957 |
| antifungal susceptibilities of candida species isolated from urine culture. | candida spp. are the most common opportunistic mycosis worldwide. although candida albicans is the most common cause of urinary tract infections, the frequency of non-albicans candida species is increasing with common use of antifungal in the prophylaxis and treatment. this may lead to difficulties in treatment. antifungal tests should be applied with identification of species for effective treatment. in this study, identification of candida species isolated from urine culture and investigation ... | 2016 | 27452427 |
| isolation frequency characteristics of candida species from clinical specimens. | candida spp. is an invasive infectious fungus, a major risk factor that can increase morbidity and mortality in hospitalized patients. in this study, 2,508 candida spp. were isolated from various clinical specimens collected from university hospitals from july 2011 to october 2014. they were identified in order to determine isolation frequencies and characteristics by specimen, gender, age group, year, season, and month. the strain-specific isolation rate of candida spp. is in the order of candi ... | 2016 | 27433120 |
| in vitro antifungal activity of different components of centratherum anthelminticum and ocimum sanctum seed oils and their synergism against oral pathogenic fungi. | background. opportunistic fungal infections like candidiasis are common in the oral cavity. in recent years candida species have shown resistance against a number of synthetic drugs. this study assessed the antifungal activity of centratherum anthelminticum and ocimum sanctum seed oils against six common pathogenic candida strains. synergistic activity of the major oil components was also studied. methods. antifungal activity of centratherum anthelminticum and ocimum sanctum seed oils were teste ... | 2016 | 27429725 |
| current trends in candidemia and species distribution among adults: candida glabrata surpasses c. albicans in diabetic patients and abdominal sources. | candidemia rate and species distribution vary according to the type of patients, country of origin and antifungal prophylaxis use. to present current candidemia epidemiological trends. a retrospective examination of candidemia in adults (≥18 years-old) hospitalised from 2007 to 2015. cases were identified through the microbiology laboratory. candida species were distinguished based on colony morphology and vitek-2 ybc cards, (biomerieux, durham, nc, usa). patient characteristics, species distrib ... | 2016 | 27402377 |
| candidemia and invasive candidiasis in adults: a narrative review. | candidemia and invasive candidiasis are major causes of morbidity and mortality, and their incidence is increasing because of the growing complexity of patients. five species of candida (candida albicans, candida glabrata, candida parapsilosis, candida tropicalis and candida krusei) account for more than 90% of all diagnosed cases, but their relative frequency varies depending on the population involved, geographical region, previous anti-fungal exposure, and patient age. the best evidence regar ... | 2016 | 27394927 |
| identification of candida species and susceptibility testing with sensititre yeastone microdilution panel to 9 antifungal agents. | to determine the species incidence and susceptibility pattern to 9 antifungal agents of yeasts isolated from various clinical specimens of colonized or infected patients treated in the coronary and surgical intensive care units (icu). | 2016 | 27381534 |
| a prospective surveillance study of candidaemia: epidemiology, risk factors, antifungal treatment and outcome in hospitalized patients. | this study provide an up-to-date overview of the epidemiology and risk factors for candida bloodstream infection in scotland in 2012/2013, and the antifungal susceptibility of isolates from blood cultures from 11 national health service boards within scotland. candida isolates were identified by chromogenic agar and confirmed by maldi-tof methods. survival and associated risk factors for patients stratified as albicans and non-albicans cases were assessed. information on the spectrum of antifung ... | 2016 | 27379047 |
| epidemiologic and microbiologic evaluation of nosocomial infections associated with candida spp in children: a multicenter study from istanbul, turkey. | the purpose of this study was to establish species distribution of candida isolates from pediatric patients in istanbul, turkey, and to determine risk factors associated with nosocomial candida infections. | 2016 | 27339794 |
| antihypertensive, amlodipine besilate inhibits growth and biofilm of human fungal pathogen candida. | candida albicans and candida glabrata are two important human pathogens associated with high mortality. the anti-candida potential of an antihypertensive drug, amlodipine besilate (ab), was studied against 10 strains of candida, including 8 clinical isolates. ab is an inhibitor of voltage-gated ca(2+) channel (vgcc) of mammals. cch1 expresses in a part of ca(2+) channel of candida, which is a homologue of α subunit of mammalian vgcc. in plate assays, all strains of candida showed sensitivity to ... | 2016 | 27336942 |
| comparison of species-level identification and antifungal susceptibility results from diagnostic and reference laboratories for bloodstream candida surveillance isolates, south africa, 2009-2010. | from february 2009 through august 2010, we compared species-level identification of bloodstream candida isolates and susceptibility to fluconazole, voriconazole, and caspofungin between diagnostic and reference south african laboratories during national surveillance for candidemia. diagnostic laboratories identified isolates to genus/species level and performed antifungal susceptibility testing, as indicated. at a reference laboratory, viable candida isolates were identified to species-level usi ... | 2016 | 27335055 |
| [pulmonary fungal infection after renal transplantation: analysis of 40 cases]. | to explore the clinical characteristics, therapeutic measures and risk factors of pulmonary fungal infection in patients after renal transplantation. | 2016 | 27320896 |
| candida duobushaemulonii: an emerging rare pathogenic yeast isolated from recurrent vulvovaginal candidiasis in brazil. | the aim of this study was to identify candida species isolated from women diagnosed with recurrent vulvovaginal candidiasis (rvvc) and their partners; and to evaluate the fluconazole (flz) susceptibility of the isolates. in a period of six years, among 172 patients diagnosed with vulvovaginal candidiasis, 13 women that presented rvvc and their partners were selected for this investigation. the isolates were obtained using chromagar candida medium, the species identification was performed by phen ... | 2016 | 27304096 |
| vapour and liquid-phase artemisia annua essential oil activities against several clinical strains of candida. | candida spp. are often the cause of infection in immune-compromised individuals. they are characterized by a strong resistance to antimicrobial drugs and disinfectants. the activity of artemisia annua essential oil against candida spp. was determined by vapour contact and microdilution assay. the oil was characterized by the presence of oxygenated monoterpenes (more than 75 % of the constituents), mainly represented by the irregular monoterpene artemisia ketone (ca. 22 %), and the widespread mon ... | 2016 | 27286334 |
| antibiofilm activity of carboxymethyl chitosan on the biofilms of non-candida albicans candida species. | although most cases of candidiasis have been attributed to candida albicans, non-c. albicans candida species have been isolated in increasing numbers in patients. in this study, we determined the inhibition of carboxymethyl chitosan (cm-chitosan) on single and mixed species biofilm of non-albicans candida species, including candida tropicalis, candida parapsilosis, candida krusei and candida glabrata. biofilm by all tested species in microtiter plates were inhibited nearly 70%. cm-chitosan inhib ... | 2016 | 27261732 |
| oral yeast colonization in peritoneal dialysis and hemodialysis patients and renal transplant recipients. | we aimed to investigate the frequency of oral yeast colonization (oyc) and the risk factors for patients who received continuous ambulatory peritoneal dialysis (capd) or hemodialysis (hd) or were renal transplant recipients (rtrs). the patients admitted to the nephrology clinic at ataturk university medical school from january through april 2013 were included in the study. a questionnaire about risk factors was filled out, and swab cultures were taken from the tongue surface of each participant. ... | 2016 | 27260810 |
| antifungal imidazole-decorated cationic amphiphiles with markedly low hemolytic activity. | herein we report that an imidazole-decorated cationic amphiphile derived from the pseudo-disaccharide nebramine has potent antifungal activity against strains of candida glabrata pathogens. in combination with the natural bis-benzylisoquinoline alkaloid tetrandrine the reported antifungal cationic amphiphile demonstrated synergistic antifungal activity against candida albicans pathogens. this unique membrane disruptor caused no detectible mammalian red blood cell hemolysis at concentrations up t ... | 2016 | 27258738 |
| isolation frequency of candida present on the surfaces of mobile phones and handsx. | it is known that mobile phones may play a role in microorganism transmission. the aim of this study was to analyze the relationship between the number of candida genera/species isolated from samples collected from the surfaces of mobile phones and the hands of the staff as well as the preferred health-related behavior. | 2016 | 27246984 |
| identification and antifungal susceptibility of candida species isolated from bloodstream infections in konya, turkey. | in this study, our aim was to identify candida species isolated from bloodstream infections and to determine their susceptibilities to various antifungal agents to demonstrate the local resistance profiles and to guide empirical treatment for clinicians. | 2016 | 27245756 |
| a substituted sulfonamide and its co (ii), cu (ii), and zn (ii) complexes as potential antifungal agents. | a sulfonamide 1-tosyl-1-h-benzo(d)imidazol-2-amine (tbza) and three new complexes of co(ii), cu(ii), and zn(ii) have been synthesized. the compounds have been characterized by elemental analyses, ftir, (1)h, and (13)c-nmr spectroscopy. the structure of the tbza, and its co(ii) and cu(ii) complexes, was determined by x-ray diffraction methods. tbza and its co(ii) complex crystallize in the triclinic p-1 space group, while the cu(ii) complex crystallizes in the monoclinic p21/c space group. antifu ... | 2016 | 27232977 |
| a thioether-stabilized d-proline-l-proline-induced β-hairpin peptide of defensin segment increases its anti-candida albicans ability. | we report a β-hairpin dual stabilizing strategy: a d-proline-l-proline (d-pro-l-pro) dipeptide as the nucleating turn, and a thioether tether as a side-chain linkage at a precisely designed position to stabilize the β-hairpin. this method was used to modify the c-terminal β-hairpin moiety of the plant defensin, pv-defensin, in order to obtain a stabilized peptide with enhanced anti-candida albicans activity (mic 84-3.0 μm), high serum stability (50 % remaining after 48 h) and low hemolysis (<10 ... | 2016 | 27194395 |
| total synthesis and in vitro bioevaluation of clavaminols a, c, h & deacetyl clavaminol h as potential chemotherapeutic and antibiofilm agents. | a highly concise and expedient total synthesis of bioactive clavaminols (1-4) has been executed using commercially available achiral compound decanol. the synthetic strategy relied on trans-wittig olefination, sharpless asymmetric epoxidation, regioselective azidolysis and in situ detosylation followed by reduction as key reactions with good overall yield. based on biological evaluation studies of all the synthesized compounds, it was observed that the clavaminol a (1) exhibited good cytotoxicit ... | 2016 | 27187861 |
| clotrimazole drug resistance in candida glabrata clinical isolates correlates with increased expression of the drug:h(+) antiporters cgaqr1, cgtpo1_1, cgtpo3, and cgqdr2. | for years, antifungal drug resistance in candida species has been associated to the expression of atp-binding cassette (abc) multidrug transporters. more recently, a few drug efflux pumps from the drug:h(+) antiporter (dha) family have also been shown to play a role in this process, although to date only the candida albicans mdr1 transporter has been demonstrated to be relevant in the clinical acquisition of antifungal drug resistance. this work provides evidence to suggest the involvement of the ... | 2016 | 27148215 |
| antimycotic activity and genotoxic evaluation of citrus sinensis and citrus latifolia essential oils. | the aim of this study was to evaluate the antifungal activity of essential oils (eos) of citrus sinensis (c. sinensis) and citrus latifolia (c. latifolia) against five candida species: candida albicans, candida tropicalis, candida glabrata, candida lusitaniae and candida guilliermondii; and perform its genotoxic evaluation. the eos of c. sinensis and c. latifolia were obtained from the peel by hydro-distillation. the major components determined by gc-ms were in c. sinensis, d-limonene (96%) and ... | 2016 | 27137128 |
| photodynamic inactivation of a multispecies biofilm using curcumin and led light. | this study evaluated the potential of curcumin-mediated antimicrobial photodynamic inactivation (api) on multispecies biofilms of candida albicans, candida glabrata, and streptococcus mutans of different ages. acrylic samples (n = 480) were made with standardized rough surfaces and incubated with bacteria and yeast for 24 or 48 h. api was performed with curcumin (80, 100, 120 μm) and led light. additional acrylic samples were treated with curcumin or led light only. positive control samples rece ... | 2016 | 27126412 |
| development of candida-specific real-time pcr assays for the detection and identification of eight medically important candida species. | culture-based identification methods have been the gold standard for the diagnosis of fungal infection. currently, molecular technologies such as real-time pcr assays with short turnaround time can provide desirable alternatives for the rapid detection of candida microbes. however, most of the published pcr primer sets are not candida specific and likely to amplify dna from common environmental contaminants, such as aspergillus microbes. in this study, we designed pan-candida primer sets based o ... | 2016 | 27103821 |
| study of strains of candida spp. isolated from catheters in uhc of oran (algeria): identification and antifungal susceptibility. | the increasing incidence of candida spp., and the vital prognosis often compromise for patients with candida species make urgent the exact knowledge of their distribution worldwide and exhaust action antifungals currently used in clinical. that why we carry out an epidemiological study of candida species and testing their susceptibility against two antifungals: amphotericin b and caspofungin. | 2016 | 27103075 |
| candida glabrata survives and replicates in human osteoblasts. | candida glabrata is an opportunistic pathogen that is considered the second most common cause of candidiasis after candida albicans many characteristics of its mechanisms of pathogenicity remain unknown. recent studies have focused on determining the events that underlie interactions between c. glabrata and immune cells, but the relationship between this yeast and osteoblasts has not been studied in detail. the aim of this study was to determine the mechanisms of interaction between human osteob ... | 2016 | 27073253 |
| pharmacokinetic/pharmacodynamic adequacy of echinocandins against candida spp. in intensive care unit patients and general patient populations. | this study evaluated whether contemporary echinocandin regimens achieved pharmacokinetic/pharmacodynamic targets in icu patients and general patient populations (gpps) and assessed caspofungin (cas) regimens in hepatic impairment (hi) patients. a monte carlo simulation was performed using previously published data. recommended dosing regimens of echinocandins in icu patients, gpps and healthy volunteers were evaluated: 70mg loading dose then 50mg maintenance dose (70/50mg) for cas; 100mg q24h fo ... | 2016 | 27068676 |
| [current aspects of invasive diseases caused by candida and other yeast fungi]. | invasive candidiasis is the most common invasive fungal disease causing an unacceptably high mortality. candida albicans remains the predominant origin, but an epidemiological shift has been described in the last decades. some species of candida have emerged as an important cause of severe candidaemia and can exhibit reduced susceptibility to the current antifungal agents. candida parapsilosis has been associated with candidaemia in neonates and young adults, whereas candida glabrata, candida tr ... | 2016 | 27067876 |
| candida glabrata binding to candida albicans hyphae enables its development in oropharyngeal candidiasis. | pathogenic mechanisms of candida glabrata in oral candidiasis, especially because of its inability to form hyphae, are understudied. since both candida albicans and c. glabrata are frequently co-isolated in oropharyngeal candidiasis (opc), we examined their co-adhesion in vitro and observed adhesion of c. glabrata only to c. albicans hyphae microscopically. mice were infected sublingually with c. albicans or c. glabrata individually, or with both species concurrently, to study their ability to c ... | 2016 | 27029023 |