Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| septicemia and meningitis in children splenectomized for hodgkin's disease. | retrospective evaluation of the occurrence of septicemia and meningitis in 200 children who had staging laparotomy iwth splenectomy for hodgkin's disease revealed 20 episodes occurring in 18 children. symptoms were usually fulminant; only 10 of these patients survived their episode. infections occurred eight days to three years after splenectomy. adolescents, as well as younger children, were affected; half were older than 10 years of age. leukopenia was not a major factor in onset or survival s ... | 1976 | 958275 |
| cephazolin treatment of pneumonia in the elderly. | cephazolin, a semi-synthetic cephalosporin for parenteral use, was evaluated in 39 elderly hospital patients. thirty-three of these patients were seriously ill at the start of treatment, suffering from pulmonary infections. in the other six patients, the drug was used post-operatively as a prophylactic, and it was effective in all cases in preventing any subsequent infection. cephazolin was very effective in the treatment of 27 of the severely ill patients; the primary pathogen was eradicated an ... | 1976 | 973593 |
| laboratory evaluation of 3-(5-tetrazolyl) penam, a new semisynthetic beta-lactam antibacterial agent with extended broad-spectrum activity. | in the new agent 3-(5-tetrazolyl)penam, hereafter referred to as cp-35,587, the carboxyl function at c3 in the penicillin nucleus has been replaced with the 5-tetrazolyl moiety. marked changes in spectrum and resistance to gram-negative beta-lactamases, particularly with regard to klebsiella pneumoniae isolates, were conferred by this modification. the anti-klebsiella activity clearly distinguishes the antibacterial spectrum of cp-35,587 from any known broad-spectrum penicillin. compared to oral ... | 1976 | 984745 |
| residual effects of septic arthritis in infancy and childhood. | septic arthritis affects weight-bearing joints in three fourths of cases. when the disease occurs in infancy, joint dysfunction may not be apparent until many months later. we located 49 children who had had 50 episodes of septic arthritis from 1 1/2 to 12 years earlier (mean, 4.3 years). thirteen patients (27%) had sequelae, and in eight (16%), there was impairment of ambulation. residual damage was more common with hip and ankle involvement than with knee joint disease. sequelae were equally c ... | 1976 | 988890 |
| pneumonia in a city hospital. | of 222 patients with pneumonia in st vincent's hospital, sydney, in 1972, more were affected by bronchopneumonia (53%) than lobar pneumonia (46%). two-thirds of the patients were males and 86% were aged 40 years or more. only 59% had any bacteriological studies performed. it was unusual to isolate pathogens from persons who had received antibiotics before cultures were taken, but of cultures taken from persons not receiving antibiotics, 65% yielded pneumococci. infections due to staphylococcus a ... | 1976 | 1004342 |
| cefamandole: in vitro and clinical pharmacokinetics. | cefamandole has a broader spectrum and greater potency than the other cephalosporins. it includes haemophilus influenzae, most strains of enterobacter, and many strains of indole-positive proteus and bacteroides, with a lower minimal inhibitory concentration for escherichia coli, klebsiella, etc. concentrations of drug in the serum after the parenteral injection of cefamandole exceed manyfold the minimal inhibitory concentrations of over 82% of the bacteria studied. approximately 65 to 85% is ex ... | 1976 | 1008540 |
| [renal tubules in experimental malacoplakia: phagocytic activity of proximal tubular epithelium (author's transl)]. | 1976 | 1022096 | |
| [meningitis and labyrinthitis in childhood]. | the haemophilus influenzae meningitis is the most common cause of deafness following meningitis. five of 22 children (23%) had this complication in spite of antibiotic treatment (ampicillin). the question must be raised whether a different antibiotic treatment could avoid the inner-ear problems occurring in haemophilus influenzae meningitis. early decompression of the internal auditory canal has reversed deafness in one of four children. | 1976 | 1034264 |
| [distribution of chromosome breakage point induced by arabinosylcytosine on in-vitro human lymphocytes]. | the cytogenetic effects of arabinosyl cytosine on human leukocytes in vitro has been studied using continuous and discontinuous treatments. optimum activity occurs at the end of the s period. interchromosomal distribution of breaks is non-random. the hypothesis of a very late replication for some chromatid segments is discussed. the relations between banding and the position of breaks are discussed. | 1976 | 1084119 |
| movement of histones in chromatin induced by shearing. | methylation of accessible dna within chromatin by restriction modification methylases from haemophilus influenzae was used to detect movement of histones along the dna strand during chromatin manipulation. methylation at different stages of chromatin preparation was followed by titration of the nucleoprotein with ploy(d-lysine), digestion of chromosomal proteins with pronase and analysis of the dna-poly(d-lysine) complex in steep cesium chloride gradients. comparison of the specific radioactivit ... | 1976 | 1084277 |
| bacteriology and pharmacokinetics of the new amidino penicillin-mecillinam. | 1976 | 1084337 | |
| similarity in properties and mapping of three rec mutants of haemophilus influenzae. | three rec- mutants of haemophilus influenzae have been studied with respect to their transformability, ultraviolet and mitomycin c sensitivities, spontaneous and ultraviolet-induced deoxyribonucleic acid breakdown, inducibility of lysogens, and the linkage of the three mutations to a streptomycin resistance marker. the data indicate that the three mutations cause the same phenotypic changes, and that they are all on the same gene. transformability of the mutants is different when two different m ... | 1976 | 1084339 |
| ultrastructural characterization of capsulated haemophilus influenzae type b and two spontaneous nontypable mutants. | capsulated haemophilus influenzae type b and two spontaneous mutants (classes i and ii variants) were characterized by transmission and scanning electron microscopy. when cells were treated with type b-specific antiserum prior to manipulations for electron microscopy, sectioned capsulated cells had electron-dense, fibrous capsular antigen-antibody complexes around them. in negatively stained preparations, the complexes appeared as electron-transparent zones surrounding cells. in contrast, only r ... | 1976 | 1084340 |
| synthesis of envelope polypeptides by haemophilus influenzae during development of competence for genetic transformation. | six polypeptides with apparent molecular weights of 95,000, 90,000, 80,000, 67,000, 64,000, and 43,000 were found to be characteristic of the cell envelopes of competent haemophilus influenzae, and were synthesized entirely during the period of competence development. two polypeptides with apparent molecular weights of 58,500 and 40,500 were synthesized during growth as well as during competence development, but were only associated with the envelope fraction of cells that had developed competen ... | 1976 | 1084341 |
| [nasopharyngeal culture results in children with acute otitis media]. | nasopharyngeal cultures in 463 children, suffering from otitis media were examined in 1968-1970. in 45% of cases h. influenzae, d. pneumoniae, s. aureus and beta hemolytic streptococci were found. these are thought to be the causative organisms for acute otitis media, however their dominance may vary. in our findings h. influenzae came first. 102 of 463 children, that is, 21.9% showed this organism. d. pneumoniae was second with 10.7%, which is generally considered as the primary cause of bacter ... | 1976 | 1084456 |
| resistance to co-trimoxazole. | 1976 | 1084551 | |
| the genetic map of bacteriophage phix174 constructed with restriction enzyme fragments. | 1976 | 1084616 | |
| reisolation and characterization of haemophilus influenzae-murium. | twenty-three haemophilus influenzae-murium strains were isolated from the nasopharynx of healthy cflp white mice. microbiological characterization of the cultures confirmed the taxonomic position of the organisms which had become problematic due to the loss of the original isolates. the type strain proposed, eo1, is available from the hungarian national collection of medical bacteria, national institute of public health, budapest as 95001. | 1976 | 1084675 |
| characterization of an ampicillin-resistant haemophilus influenzae type b. | a 28-year-old female in denver was found in early 1974 to have frontal sinusitis, osteomyelitis, and bacteremia due to haemophilus influenzae, type b. the minimal inhibitory concentration of ampicillin for this organism was 100 mug/ml and the minimal bactericidal concentration was >100 mug/ml. it was inhibited by chloramphenicol at 0.4 mug/ml. further studies demonstrated that ampicillin and methicillin were synergistic against this organism. it was shown to produce a diffusible beta-lactamase. ... | 1976 | 1084727 |
| reversions of two proline-requiring auxotrophs of haemophilus influenzae by n-methyl-n'-nitro-n-nitrosoguanidine and hydrazine. | new mutation detection systems are described for haemophilus influenzae. they involve two independently isolated proline auxotrophs which appear to be mutants at different sites in a proline locus (prob) that is very closely linked to a locus (thd) for thymidine requirement. one of the mutants, prob1, appears to revert to prototrophy only by mutations at the locus. the other, prob2, reverts both by mutation at the locus and by unlinked suppressors. the latter account for about 90% of the reversi ... | 1976 | 1084955 |
| fixation and loss of hydrazine-induced premutational damage in haemophilus influenzae. | premutational damage induced in haemophilus influenzae by hydrazine appears to be fixed as final mutation only at replication as judged by the transformation assay. fixation at replication is independent of the rec1 gene, unlike the case with nitrosocarbaryl. prior to replication premutational damage induced by hydrazine disappears by an unknown process that is not dependent on the presence of a pyrimidine dimer excision system nor on the rec1 gene. hydrazine does not produce detectable single-s ... | 1976 | 1084956 |
| letter: surveillance of haemophilus influenzae resistance. | 1976 | 1084959 | |
| biological properties of a haemophilus influenzae restriction enzyme, hind i. | a type i restriction enzyme from haemophilus influenzae, hind i, which requires adenosine 5' -triphosphate and 5-adenosyl methionine, was studied for its activity on transfecting and transforming deoxyribonculeic acid (dna). the enzyme reduced the size of unmodified bacteriophage s2 dna from 37 x 10(6) daltons to approximately 10 x 10(6) daltons, but did not affect modified s2 dna. unmodified transforming dna was attacked in vitro by hind i; however, relatively low levels of inactivation were ob ... | 1976 | 1085299 |
| a specific endonuclease from haemophilus haemolyticus. | 1976 | 1085372 | |
| degradation of dna in haemophilus influenzae cells after x-ray irradiation. ii. comparison with theoretical models. | 1976 | 1085388 | |
| bacteriophage n3 of haemophilus influenzae. i. independence of vegetative recombination among haemophilus influenzae bacteriophage on the host cell. | vegtative recombination of temperature-sensitive mutants of haemophilus influezae bacteriophage n3 was measured in wild-type h. influenzae strain rd9 and in recombination-defective mutants of the rd strain. recombinants are formed with low but equal frequency in wild-type cells and recombination-defective mutants of the rd strain. it is concluded that this phage can carry information in its own genome for vegetative recombination. lysogenization readily takes place in both strains. | 1976 | 1085411 |
| evaluation of a rapid beta-lactamase test for detecting ampicillin-resistant strains of hemophilus influenzae type b. | chloramphenicol is presently the drug of choice in the initial treatment of serious infections due to hemophilus influenzae type b. rapid detection of ampicillin resistance in clinical isolates would facilitate early discontinuation of chloramphenicol therapy in patients infected with ampicillin-sensitive bacteria. a total of 160 strains of h. influenzae type b were tested with a one-hour acidimetric microassay for beta-lactamase activity. all ampicillin-resistant strains rapidly hydrolysed the ... | 1976 | 1085435 |
| epidemiologic characteristics of infections caused by ampicillin-resistant hemophilus influenzae. | hrom february 1974 through may 1975, 58 isolates of ampicillin-resistant hemophilus influenzae from patients were submitted to the center for disease control from 23 states and the district of columbia. the epidemiologic characteristics of these widely scattered cases were strikingly similar to those of cases previously reported from individual communities or institutions. because of the nationwide distribution of resistant isolates and the adverse consequences of ineffective therapy, the use of ... | 1976 | 1085436 |
| ampicllin sensitivity and biotypes of recent danish isolates of haemophilus influenzae. | among 148 strains of haemophilus influenzae isolated in 1975 from different localities in denmark, none was found to be resistant to ampicillin. a majority of the strains belonged to biotypes i, ii and iii and the presence of a partial correlation between biotype and origin was confirmed. | 1976 | 1085556 |
| adult hemophilus influenzae pericarditis. | 1976 | 1085707 | |
| identification and quantitation of capsular antigen in capsulated and noncapsulated strains of haemophilus influenzae type b by crossed-immunoelectrophoresis. | sonicated preparations of capsulated haemophilus influenzae type b, two of its spontaneous mutants, one containing patches of capsules (class i variant) and the other noncapsulated (class ii variant), and a noncapsulated strain of h. influenzae type d were analyzed by crossed-immunoelectrophoresis using unadsorbed antiserum to capsulated h. influenzae type b. twenty common antigens were present in all four cultures. two type b-specific antigens were also identified in the three h. influenzae typ ... | 1976 | 1085750 |
| mechanism of dna degradation by the atp-dependent dnase from hemophilus influenzae rd. | the rate of production of acid-soluble material during degradation of duplex dna by hemophilus influenzae atp-dependent dnase (hind exonuclease v) has been shown to be directly dependent upon the mg2+ concentration in the reaction mixture. at high concentrations of mg2+ (5 to 20 mm), dna degradation to acid-soluble products is rapid and the rate of atp hydrolysis is slightly depressed. at low concentrations of mg2+ (0.1 to 0.5 mm), the enzyme rapidly hydrolyzes atp and converts up to 35% of line ... | 1976 | 1085772 |
| hemophilus influenzae, type b, antibody frequencies determined with bactericidal and radioimmunoassay tests. | bactericidal and radioimmunoassay (ria) antibodies to hemophilus influenzae, type b, were measured in the sera of 85 children aged 18 through 71 months. bactericidal antibodies were present in only 21% of those over 60 months; ria levels rose linearly with increasing age (p less than 0.005). bactericidal antibodies were present in nine of 29 sera with ria levels greater than or equal to 0.7 mug/ml and in only four of 56 sera with ria levels less than 0.7 mug/ml (p less than 0.01). the discrepanc ... | 1976 | 1085776 |
| the paradox of hemophilus infuenzae type b bacteremia in the presence of serum bactericidal activity. | we investigated the role of serum bactericidal activity in hemophiplus influenzae type b infections in infants with meningitis and in a rat model. in infected infants, 13/22 admission sera had bactericidal activity against the infecting strain, and bacteremia was as frequent in those with bactericidal activity (54%) as those without (56%). the coexistence of bactericidal activity and bacteremia was reproduced and studied in experimentally infected weanling rats. serum from such rats kills in vit ... | 1976 | 1085778 |
| mutation induction by mnng in a bacteriophage of haemophilus influenzae. | three temperature-sensitive mutants of the haemophilus influenzae phage hp1c1 were tested for reversion to wild type (ts leads to ts+). treatment with n-methyl-n'-nitro-n-nitrosoguanidine (mnng) produced revertants at levels up to 0.1% of the total progeny phage from treated lysogens. cells treated with mnng after infection with whole ts phage produced progeny phage with similar reversion frequencies, but when the uninfected cells or the phage were treated alone no reversion was induced. fixatio ... | 1976 | 1085914 |
| epiglottitis: incidence of extraepiglottic infection: report of 72 cases and review of the literature. | a review of 72 cases of epiglottitis seen at the children's hospital of denver was undertaken to determine the incidence of extraepiglottic and septic foci in this disease. a parallel review of the literature was also undertaken. the clinical, bacteriologic, laboratory, and radiologic findings of this patient population are described. a 25% incidence of both pneumonia and cervical lymphadenitis was found to be associated with this illness. exudative tonsillitis and otitis media were the only oth ... | 1976 | 1085924 |
| cleavage map of bacteriophage phix174 rf dna by restriction enzymes. | phix rf dna was cleaved by restriction enzymes from haemophilus influenzae rf (hinf i) and haemophilus haemolyticus (hha. i). twenty one fragments of approximately 25 to 730 base pairs were produced by hinf i and seventeen fragments of approximately 40 to 1560 base pairs by hha i. the order of these fragments has been established by digestion on haemophilus awgyptius (hae iii) and arthrobacter luteus (alu i) endonuclease fragments of phix rf with hinf i and hha1. by this method of reciprocal dig ... | 1976 | 1085927 |
| hearing loss as a sequel to chloramphenicol and ampicillin treatment of haemophilus influenzae meningitis. | 20 patients with haemophilus influenzae meningitis who had been treated with chloramphenicol over the period 1959-1970 and 23 patients who had been treated with ampicillin over the period 1968-1974 were re-examined by hearing tests in 1975. in all the cases the two agents had been given initially by the parenteral route, chloramphenicol in doses varying between 50 and 150 (averaging 101) mg/kg/day and ampicillin in doses varying between 125 and 350 (averaging 229) mg/kg/day. five of the 20 patie ... | 1976 | 1085985 |
| haemophilus influenzae as an agent of urinary tract infectio.?w0c. | 1976 | 1086036 | |
| [new endonuclease hind-glu from haemophilus influenzae rd 123]. | 1976 | 1086198 | |
| effect of adenosine 5'-triphosphate-dependent deoxyribonuclease deficiency on properties and transformation of haemophilus influenzae strains. | a transformation-deficient strain of haemophilus influenzae, lacking adenosine 5'-triphosphate-dependent deoxyribonuclease activity, was isolated by selection for sensitivity to mitomycin. the mutant, designated jk57, possibily showed a moderate sensitivity to ultraviolet (uv) irradiation and treatment with methyl methane sulfonate. contrary to the wild type, the mutant degraded chromosomal deoxyribonucleic acid (dna) to some extent. however, after uv irradiation to the mutant degraded considera ... | 1976 | 1086303 |
| meningitis due to haemophilus influenzae type e. | haemophilus influenzae type e was isolated from the cerebrospinal fluid and blood of an 8-month-old child with meningitis. | 1976 | 1086307 |
| letter: no mouse model for h. influenzae infection. | 1976 | 1086309 | |
| incidence of ampicillin-resistant hemophilus influenzae in otitis media. | ampicillin resistance in hemophilus influenzae type b causing serious infections is appreciated, but little is known about ampicillin resistance in nonencapsulated strains causing otitis media. the ampicillin sensitivity of 984 middle-ear isolates of h. influenzae from children in huntsville, ala. obtained from 1970-1976, was examined: nine ampr isolates were found: one in 1973, two in 1974, three in 1975, and three in the first five months of 1976. seven strains were nonencapsulated; two were t ... | 1976 | 1086351 |
| h. influenzae buccal cellulitis and otitis media. | 1976 | 1086353 | |
| formation of the parental replicative form of bacteriophage phix174. | 1976 | 1086367 | |
| use of a restriction endonuclease in analyzing the genomes from two different strains of vaccinia virus. | a restriction endonuclease from haemophilus influenzae (hind iii) specifically cleaved vaccinia dna into 14 fragments. the molecular weights of these fragments were determined by gel electrophoresis and ranged from 0.5 x 10(6) to 30 x 10(6). hind iii digestion of the dna from the wr and cv-1 strains of vaccinia revealed a small molecular difference in one of the resulting fragments. the average molecular weight of the entire vaccinia genome was calculated to be 125 x 10(6). | 1976 | 1086369 |
| [haemophilus influenzae infections in patients with chronic bronchitis in the light of serum immunoelectrophoresis and bacteriological sputum examination]. | 1976 | 1086466 | |
| haemophilus from the lower respiratory tract of patients with cystic fibrosis. | fifty-six non-haemolytic haemophilus strains were isolated during current bacteriological examinations from material from the lower respiratory tract of 39 patients with cystic fibrosis during a 6-month period. except for six strains which belonged to haemophilus parainfluenzae, all strains were identified as haemophilus influenzae. biotype i of h. influenzae was the predominating taxon (38%) and was especially related to patients with recurrent or prolonged colonization. only two strains were c ... | 1976 | 1086508 |
| immunodeficiency syndromes with otorhinolaryngological manifestations. | among patients with recurrent, protracted or chronic infections of the respiratory tract involving the middle ear, 18 were found to have immunodeficiencies. in 10 of the patients, deficiency of immunoglobulins belonging to the igg, iga and igm classes was found. seven patients had an isolated iga deficiency. one patient had a combined immunodeficiency with defects of the t-cell system and the b-cell system. one patient had an isolated t-cell deficiency. | 1976 | 1086576 |
| haemophilus influenzae cellulitis. | 1976 | 1086593 | |
| cellulitis due to haemophilus influenzae type b. antigenemia and antibody responses. | the techniques of serum countercurrent immunoelectrophoresis, hemagglutinating (ha), and bactericidal (bc) antibody determinations were applied to seven patients with haemophilus influenzae type b cellulitis. capsular antigen was detected (greater than or equal to 10 ng/ml) in two patients at the time of admission and was found in two additional patients two days following hospitalization. antibody responses in the patients with cellulitis were deficient, similar to those in children under 2 yea ... | 1976 | 1086594 |
| need for "counter-detailing" antibiotics. | selected antibiotic advertisements in medical journals are discussed to illustrate the misleading information that is often disseminated to physicians by the pharmaceutical industry. laboratory and clinical data are presented to question the validity of selected advertisements which (1) encourage the use of keflex for severe respiratory infections in children, (2) recommend the use of keflex for the treatment of bacterial bronchitis, (3) suggest that high tissue penetration is a unique property ... | 1976 | 1086598 |
| susceptibility of haemophilus influenzae type b to cefatrizine, ampicillin, and chloramphenicol. | the susceptibility of 269 isolates of haemophilus influenzae type b to cefatrizine (bl-s640), ampicillin, and chloramphenicol was evaluated by disk diffusion susceptibility tests, using a modified bauer-kirby method. broth dilution susceptibility tests were performed on 88 of these isolates, including all isolates resistant by disk to cefatrizine or ampicillin. six of the isolates were resistant by disk to cefatrizine (zone size, <16 mm), four were resistant to ampicillin (zone size, <19 mm), an ... | 1976 | 1086634 |
| new method for detecting in vitro inactivation of penicillins by haemophilus influenzae and staphlycoccus aureus. | a new technique for detecting penicillinase production in haemophilus influenzae and staphylococcus aureus was compared with the capillary procedure for detecting beta-lactamase and the bauer-kirby disk susceptibility procedure. isolates were classified similarly by all three procedures. | 1976 | 1086635 |
| hemophilus influenzae empyema--two cases. | 1976 | 1086756 | |
| ampicillin and an ester in experimental hemophilus influenzae meningitis. | a new methoxymethyl ester of hetacillin is highly lipid-soluble, a property which was expected to enhance its penetration into the central nervous system (cns). we compared the penetration of the ester and ampicillin into the cerebrospinal fluid (csf) of normal rabbits and those with experimental hemophilus influenzae meningitis. in normal rabbits treated by constant intravenous infusion, mean per cent penetration (see article) of the ester was four times as great as that of ampicillin (6.6 +/- ... | 1976 | 1086758 |
| the use of antibiotics actinomycin d and distamycin a for mapping of phage lambda hindiii fragments. | 1976 | 1086799 | |
| experimental endogenous endophthalmitis caused by haemophilus influenzae type b. | experimental endogenous endophthalmitis was produced in infant rats by either intranasal or intraperitoneal inoculation with haemophilus influenzae type b and 5 days of age. the ocular disease occurred in about 50% of bacteremic animals who survived to age 12 days and probably represents metastatic bacterial infection secondary to hematogenous seeding. the lesion was a highly destructive suppurative endophthalmitis that ultimately progressed to panophthalmitis and was followed by organization of ... | 1976 | 1086831 |
| participation of complement in the nonimmune host defense against experimental haemophilus influenzae type b septicemia and meningitis. | this study was undertaken to determine whether the terminal complement components (c3-9) are involved in the nonimmune host defense against haemophilus influenzae type b septicemia and meningitis. using cobra venom factor, infant rats were depleted of c3 and c5. after intranasal challenge with h. influenzae type b, the complement-depleted rats developed a greater incidence and magnitude of bacteremia and a higher mortality rate. in contrast to the effects on bacteremia, complement depletion did ... | 1976 | 1086832 |
| factors affecting pharyngeal haemophilus influenzae type b colonization rates in children. | over 1,300 children were studied in an analysis of factors that might affect pharyngeal colonization with haemophilus influenzae type b. our semiquantitative methods for the culture of h. influenzae type b, consisting of inoculation of 0.001 ml of throat swab fluid on antiserum agar plates and division of the results into three grades of intensity, showed agreement as to intensity of colonization in over 80% of repeat throat cultures. our data also suggest that throat swabs are more efficient th ... | 1976 | 1086855 |
| serologic responses of children with meningitis due to haemophilus influenzae type b. | the immunologic responses of 100 children hospitalized with meningitis due to haemophilus influenzae type b were measured by the bactericidal antibody assay (baa) and radioimmunoassay (ria) for detection of antibody. short-term (14-17 days after onset of illness) responses were detected by ria alone in 20 children, by baa alone in six, and by both tests in 23. the more sensitive ria detected 20 children who would have been labeled "immunologically unresponsive" had only baa been used. the magnit ... | 1976 | 1086875 |
| amikacin in the treatment of gram-negative bronchopulmonary infections. | six patients with acute gram-negative bronchopulmonary infection were treated with amikacin (15 mg/kg per day) administered intramuscularly in two equal doses at 12-hr intervals for 10-13 days. two patients had underlying nonspecific pulmonary disease, two had advanced bronchocarcinoma, and two had extensive bronchiectasis (due to chronic aspergillosis in one patient). the pathogens were pseudomonas aeruginosa in three patients, and haemophilus influenzae, klebsiella ozaenae, and enterobacter cl ... | 1976 | 1086876 |
| resistance of h. influenzae to ampicillin. | 1976 | 1086894 | |
| acute otitis media caused by ampicillin-resistant haemophilus influenzae type b. | 1976 | 1086911 | |
| meningitis and ampicillin-resistant haemophilus influenzae. | 1976 | 1086954 | |
| bacterial infections and venereal diseases. | 1976 | 1086998 | |
| hemophilus influenzae type b sepsis in infant and mother. | 1976 | 1087002 | |
| serological studies in acute maxillary sinusitis. | a comparison was performed between bacteriological and serological findings in 97 patients suffering from acute maxillary sinusitis. a significant titre change (larger than or equal to 2 titre steps) of complement-fixing antibodies to h. influenzae was demonstrated in 15 patients. h. influenzae was demonstrated in aspirated sinus secretions from 7 of these 15 patients. further, titre changes to neisseria catarrhalis were demonstrated in 25 patients. no significant titre changes in anti-streptoly ... | 1976 | 1087097 |
| tone audiometry control of children treated for meningitis with large intravenous doses of ampicillin. | thirty-seven children treated for bacterial meningitis with ampicillin in high doses were followed up with audiometric control. defects were recorded in 6 cases. two of these were ascribed to chronic otosalpingitis. in 4 patients with sensorineural hearing loss, 3 were unilateral, and in only one case was the damage bilateral. even here there was a previous history of hearing loss. a suggested ototoxicity of ampicillin could not be confirmed. | 1976 | 1087098 |
| the taxonomy of haemophili isolated from conjunctivae. | the paper provides a description of 112 haemophilus strains isolated from cases of conjunctivitis in egypt, tunisia, denmark, and the u.s.a., and aims at a clarification of the taxonomy of haemophili implicated in conjunctivitis. although the study confirms the diversity of haemophili which can be isolated from inflamed conjunctivae, the vast majority of strains could be assigned to either biotype ii or iii of h. influenzae. thirteen strains possessed all the characteristics of the koch-weeks ba ... | 1976 | 1087099 |
| haemophilus influenzae meningitis: an evolving therapeutic regimen. | ampicillin sodium has been the drug of choice in the treatment of haemophilus influenzae meningitis. the development of ampicillin-resistant strains forces the clinician to focus on alternative therapies. we describe two patients in whom neutropenia was noted secondary to chloramphenicol administration, and streptomycin sulfate and sulfonamides were employed. an historical perspective summarizing the evolution of available therapeutic regimens is presented. | 1976 | 1087110 |
| acute epiglottiditis in an adult. | 1976 | 1087174 | |
| thymus dependence of rabies vaccine. | immune responses to rabies vaccine were compared with those to known thymus-dependent and thymus-independent antigens, in nude mice and their normal litter mates. no antibody response to, or protection against, challenge was observed in nude mice inoculated with either 1 or 2 doses of rabies vaccine. a single dose of the same vaccine induced a substantial antibody response and protected normal mice. these data indicate that the antigens in rabies vaccine that induce neutralizing antibody and pro ... | 1976 | 1087335 |
| nucleosides. 1. 9-(3'-alkyl-3'-deoxy-beta-d-ribofuranosyl)adenines as lipophilic analogues of cordycepin. synthesis and preliminary biological studies. | a series of lipophilic 9-(3'-alkyl-3'-deoxy-beta-d-ribofuranosyl)adenines of increasing chain length was synthesized from the corresponding branched sugars via titanium chloride catalyzed ribosylation of chloromercuri-6-benzamidopurine. enhanced growth inhibitory activity was observed against (ccrf-cem human lymphoblastic leukemia cells in culture as the length of the alkyl side chain in the sugar and the resultant lipophilic character of the nucleoside were increased. experiments involving inco ... | 1976 | 1087343 |
| cytotoxicity responses to melanoma cells by human lymphoid cell subpopulations. | lymphoid cell subpopulations from normal donors and patients with malignant melanoma were assessed for cytotoxicity. unfractionated mononuclear cells and t-cells from melanoma patients gave cell-mediated cytotoxic (cmc) responses to melanoma target cells but not to human fibroblasts. these specific cmc responses to melanoma cells were partially inhibited by autologous serum. non-t-cells and nonrosetting cells from melanoma patients were not directly cytolytic for melanoma target cells; however t ... | 1976 | 1087348 |
| ampicillin-resistant strains of haemophilus influenzae type b in north carolina. | 1976 | 1087376 | |
| nystagmic modulation of neuronal activity in rabbit cerebellar flocculus. | 1. the responses of neuronal elements in the flocculus of the awake, restrained rabbit were recorded during horizontal vestibular nystagmus in the dark. 2. purkinje cells showed both vestibular (types i and ii) and eye movement modulation of simple spike activity. type i purkinje cells most commonly were inhibited in association with the ipsilaterally directed fast phase of nystagmus and excited during contralaterally directed fast phases. type ii purkinje cells had a similar modulation but in t ... | 1976 | 1087403 |
| iodination as a probe for small regions of disrupted secondary structure in double-stranded dnas. | conditions were established where the thallium-catalyzed iodination of random coil dna proceeded 100-200 times faster than for native dna. this reaction was explored as a probe for localized regions of disrupted base pairs in duplex dna. a heteroduplex was constructed between dna fragments produced by hind ii + iii cleavage of phi80 plac dna and phi80 plac dna containing the ll deletion (73 nucleotides in length). this heteroduplex incorporated twelve times as much iodine as the parent homoduple ... | 1976 | 1087408 |
| [long-term cardiac arrest by cardioplegic coronary perfusion (author's transl)]. | the mg++ aspartate-procaine-cardioplegia has been proven in animal experiments as well as from 1970 til 1975 in more than 1000 open-heart-procedures by a myocardial temperature of 32 degrees c and aortic crossclamping time up to 40 minutes superior to all other known procedures of cardiac preservations. to guarantee a safe myocardial protection of the arrested heart for a remarkable longer period of total ischemia, we further developed the cardioplegic technique in the animal lab, and use it now ... | 1976 | 1087482 |
| energy metabolism of some representatives of the haemophilus group. | the purpose of this investigation was to characterize the carbohydrate catabolism and the constellation of the respiratory chain components of haemophilus influenzae ramc 18 bensted, h. parainfluenzae 1 fleming, h. parainfluenzae 429 pittman and h. aegyptius 180a pittman. these strains represent several physiological types with respect to respiratory quinones and glucose catabolism. on addition of glucose or lactate to the complex growth medium a remarkable increase in cell mass was observed. de ... | 1976 | 1087860 |
| [letter: hearing disorders after ampicillin treatment of haemophilus influenzae meningitis]. | 1976 | 1246715 | |
| renaturation of bacteriophage lambda dna. determination of the optimal renaturation conditions using a single-strand-specific dnase and alkaline-sucrose-gradient assay system. | reannealed hybrid molecules of wild-type bacteriophage lambda dna were prepared in aqueous solutions of formamide at a variety of nacl concentrations at both room temperature ( 22 degrees c) and 37 degrees c. treatment of the hybrid dna molecules with the single-strand-specific nuclease s1 from aspergillus oryzae followed by alkaline sucrose gradient sedimentation was used to monitor the extent and fidelity of hybridization. the optimal renaturation conditions at room temperature were found to b ... | 1976 | 1248479 |
| changes in vascular permeability associated with acetic acid-induced gastrin ulcer in rats. | gastric ulcer was induced in rats by application of acetic acid to the anterior wall of the stomach. leakage of circulating albumin into the gastric wall was estimated by intravenous injection of radioactive albumin and determination of the radioactivity in different samples of the stomach wall. the protein leakage was found to be markedly increased in the anterior wall of the stomach, the increase being most pronounced close to the ulcer. the leakage remained fairly constant during the first 10 ... | 1976 | 1248499 |
| [environment or health. balance of nature and man]. | 1976 | 1251498 | |
| [editorial: helsinki declaration.ii]. | 1976 | 1251534 | |
| editorial: red cell ageing and death. | to obtain red cell populations of increasing mean age erythropoiesis was arrested through continuous actinomycin treatment or maintained transfusion polycythemia in mice and rats respectively. the parameters studied included cell indices, enzyme activities and rheological characteristics. further, the life-span of aged cells was compared to normal, and the sequestration site was determined. mice erythrocytes, like those of rats, exerienced a continuous decrease in mcv1, an early rise in mchc, a ... | 1976 | 1251580 |
| chromosome studies on 944 black newborn infants. | 1976 | 1255805 | |
| comparative study of the in vitro antibacterial activity of cefoxitin, cefuroxine, and cephaloridine. | the in vitro antibacterial effects of cefoxitin, a semisynthetic cephamycin, cefuroxime, a new cephalosporin antibiotic, and cephaloridine were compared. with gram-positive bacteria, marked differences were found only in the effects against streptococcus faecalis, where cephaloridine and cefuroxime were superior to cefoxitin. with gram-negative aerobic bacteria, cefoxitin, which is known to be more resistant to beta-lactamases from gram-negative bacteria than any cephalosporin, was found to be m ... | 1976 | 1259406 |
| cefuroxime, a new cephalosporin antibiotic: activity in vitro. | cefuroxime is a new broad-spectrum cephalosporin antibiotic with increased stability to beta-lactamases. this stability, although no absolute in all cases, has the effect of widening the antibacterial spectrum of the compound so that many organisms resistant to the established cephalosporins are susceptible to cefuroxime. it is active against gram-positive organisms, including penicillinase-producing staphylococci, but it is less active against methicillin-resistant strains. in addition to its h ... | 1976 | 1259407 |
| the detection of antibodies in human and animal filariases by counterimmunoelectrophoresis with dirofilaria immitis antigens. | counterimmunoelectrophoresis revealed the presence of precipitin antibody in all of 6 dogs and the 1 cat infected with dirofilaria immitis and in the serum of 17 of 24 individuals living in a setting of hyperendemic subperiodic bancroftian filariasis. antigens used in the test were prepared from microfilariae and adult male d. immitis. some humans and animals had antibodies to both antigens while others had antibodies against microfilariae or adult worms only. the presence of soluble circulating ... | 1976 | 1262695 |
| attenuated, streptomycin-dependent salmonella typhi oral vaccine: potential deleterious effects of lyophilization. | four studies were done with streptomycin-dependent salmonella typhi as an oral, attenuated vaccine. studies 1 and 3 employed freshly harvested vaccine, whereas studies 2 and 4 involved lyophilized vaccine. five to eight doses (3 x 10(10)-10(11) organisms/dose) were given; oral streptomycin (1.0 g) was administered concomitantly in studies 2 and 3, with only two of the doses of vaccine in study 1, and was not given in study 4. no adverse reactions were encountered in 179 vaccinated men, and 94% o ... | 1976 | 1262709 |
| the in vitro spectrum of the cephalosporins. | the cephalosporins may currently be classified according to their relative susceptibility to beta-lactamases. cefoxitin, cefamandole, cefatrizine, and cephanone are relatively resistant to the gram-negative beta-lactamases, whereas cephalothin, cefamandole, and cefoxitin are resistant to staphylococcal beta-lactamase. although the inhibitory activity of cephalothin is representative of that of cephaloridine, cephalexin, cefazolin, cephapirin, cephacetrile, and cephradine, there are significant d ... | 1976 | 1263595 |
| kennel cough: vaccination against bordetella bronchiseptica infection. | 1976 | 1266000 | |
| role of infection in chronic bronchitis. | twenty-five patients with chronic bronchitis were studied intensively from 1968 to 1972. viral, bacteriologic, mycologic, and mycoplasmal studies, both serologic and cultural, were carried out in an attempt to determine the role these agents play in exacerbations. all of the usual viral agents associated with exacerbations and 2 members of the coronavirus group, 229e and oc43, were detected. one third (33.6 per cent) of the 116 exacerbations observed could be related to viral infection or mycopl ... | 1976 | 1267252 |
| antibacterial activity of cefuroxime, a new cephalosporin antibiotic, compared with that of cephaloridine, cephalothin, and cefamandole. | the in vitro activity of cefuroxime, a new cephalosporin derivative, was compared with that of cephaloridine, cephalothin, and cefamandole against strains of gram-positive and gram-negative bacteria recently isolated from clinical sources. cefuroxime showed very similar activity to cefamandole against staphylococcus aureus, haemophilus influenzae, and most members of the enterobacteriaceae. it was more active than cefamandole against gonococci, pneumococci, and most streptococci. increasing the ... | 1976 | 1267441 |
| acute orbital cellulitis. | a review of 104 patients with acute orbital cellulitis during the past decade showed that the frequency of hospital admissions for this disease has increased recently. roentgenograms showed paranasal sinus in 77 of 91 patients. haemophilus influenzae and diplococcus pneumoniae were recovered from the blood of 20 and 6 patients, respectively. four children had concomitant h influenzae meningitis. bacteremia was demonstrated in 29% and more common in those with extensive orbital involvement, those ... | 1976 | 1267655 |
| [letter: effect of temperature on the structural state of lipids in mitochondrial membranes]. | 1976 | 1268293 | |
| concentration--time relationship for various regimens of inhalation of organic compounds. | an attempt was made to establish a concentration--time relationship for continuous and interrupted inhalation of a number of nonelectrolytes to establish norms for the permissible content of harmful substances in atmospheric air. the tests showed that the indicated relationship can be expressed in the form of a straight line on a logarithmic grid by using either acute toxicity parameters or the onset of physiological and biochemical shifts. this makes it possible to predict the chronic effect th ... | 1976 | 1269502 |
| studies on the central vasomotor reflexes in cats after intraventricular administration of whole venom of dendroaspis jamesoni. | 1976 | 1273859 |