Publications

[evaluation of the usefulness of routine serologic tests in the diagnosis of human brucellosis in the current epidemiologic situation].		1986	3575762
angiostrongylus cantonensis infection in ampullarius canaliculatus (lamarck) in kyushu, japan.	ampullarius canaliculatus is a large fresh-water snail of which the original habitat is said to be argentina. recently, the snail which grew wild has propagated in various parts of japan, and is causing damage to aquatic plants by feeding on them. the present study was performed to find out whether the snail can be a suitable intermediate host for angiostrongylus cantonensis. natural infection with a. cantonensis was confirmed in the snails collected from 5 different places in 4 hamlets in okina ...	1986	3576290
disk diffusion susceptibility of branhamella catarrhalis and relationship of beta-lactam zone size to beta-lactamase production.	we tested 231 isolates of branhamella catarrhalis for beta-lactamase production and drug susceptibility by the national committee for clinical laboratory standards disk diffusion method. the nitrocephin disk (cefinase) identified beta-lactamase in 98% of the enzyme-producing strains, and a zone diameter of inhibition of less than or equal to 29 mm for penicillin correctly predicted the presence of beta-lactamase in 99% of the isolates. no resistance to erythromycin, tetracycline, trimethoprim-su ...	1986	3492178
respiratory failure and lethal hypotension due to blue-ringed octopus and tetrodotoxin envenomation observed and counteracted in animal models.	the effects of crude blue-ringed octopus venom gland extract and tetrodotoxin (ttx) on anaesthetised rats and rabbits were studied. paralysis of the respiratory musculature causing anoxia and cyanosis was overcome with positive, artificial respiration. the second lethal mechanism of the toxins: rapid and severe hypotension, had to be counteracted peripherally, since neural transmission had been drastically reduced by the toxins. noradrenaline, d-amphetamine, phenylephrine and methoxamine, agonis ...	1986	3573123
prevalence of intestinal parasitic infections in riyadh district, saudi arabia.	a total of 23,516 stool specimens collected from patients attending three medical centres in riyadh, saudi arabia, were examined for intestinal parasites. of these 5737 (24.4%) were positive. entamoeba histolytica (8.8%) and giardia lamblia (6.3%) were the commonest parasites found, and in the age group of one to 15 years. giardia was found in 14.8% of males and 11.9% of females. other intestinal parasites present included ascaris lumbricoides, trichuris trichiura, schistosoma mansoni, hymeolepi ...	1986	3675035
glial differentiation in dissociated cell cultures of neonatal rat brain: noncoordinate and density-dependent regulation of oligodendroglial enzymes.	the mixed glial system of primary cultures of cells dissociated from neonatal rat brain was utilized to study glial differentiation. the investigation was addressed specifically to the possibility of noncoordinate regulation of two manifestations of oligodendroglial differentiation, i.e., activities of glycerol-3-phosphate dehydrogenase (gpdh) and of 2',3'-cyclic nucleotide 3'-phosphohydrolase (cnp), as well as the effects of initial cell density on the time of onset and the intensity of express ...	1986	2870195
transglutaminase and neuronal differentiation.	during mouse brain maturation cellular transglutaminase specific activity increases 2.5 fold from day 3 to adulthood. a more pronounced increase is seen during morphological differentiation of mouse neuroblastoma cells, where serum withdrawal induces neurite outgrowth concomitant with a 10 fold increase in transglutaminase specific activity. in contrast, non-dividing neuroblastoma cells lacking neurites show only a 1.5 fold increase in enzyme specific activity. transglutaminase activity does not ...	1986	2870428
transglutaminase and neuronal differentiation.	during mouse brain maturation cellular transglutaminase specific activity increases 2.5 fold from day 3 to adulthood. a more pronounced increase is seen during morphological differentiation of mouse neuroblastoma cells, where serum withdrawal induces neurite outgrowth concomitant with a 10 fold increase in transglutaminase specific activity. in contrast, non-dividing neuroblastoma cells lacking neurites show only a 1.5 fold increase in enzyme specific activity. transglutaminase activity does not ...	1986	2870428
integrating treatments in schizophrenia.	schizophrenia is a common and severe illness found throughout the world. onset is usually in adolescence and young adulthood, and many individuals have illness-related impairments for life. schizophrenia assaults the very essence of what is distinctly human. the personality is devastated, subjective experience and thought distorted, and the psychological building blocks of everyday life torn asunder. this article discusses diagnostic and conceptual considerations, pharmacotherapy, and interperso ...	1986	2870478
influence of dietary lipids on the effect of chlorpromazine on membrane properties of rabbit red cells.	the effect of diets containing different types of common natural oils on physical properties of red cells was investigated by using rabbits. the rabbits were fed for 18 months on a standard diet in which 8% of its energy content was provided by safflower oil and 32% energy by either more safflower oil or fish oil, linseed oil, olive oil or palm oil. erythrocyte deformability was significantly decreased by the fish oil diet compared with each of the other diets. osmotic fragility was significantl ...	1986	2870499
platelet aggregation caused by carybdea rastonii toxins (crtx-i, ii and iii) obtained from a jellyfish, carybdea rastonii.	the pharmacological mechanisms of platelet aggregation induced by highly toxic proteins (crtx-i, crtx-ii, and crtx-iii) obtained from tentacles of a jellyfish, carybdea rastonii, were investigated. when the partially purified toxin (pcrtx) and crtxs were added to the citrated platelet-rich plasma (prp), aggregation was produced in a concentration-dependent manner. the activity of crtxs was approximately 100 times more potent than pcrtx. the crtxs-induced aggregation was little affected by indome ...	1986	2870502
blood-finding strategy of a capillary-feeding sandfly, lutzomyia longipalpis.	salivary gland homogenates of adult female lutzomyia longipalpis inhibited platelet aggregation induced by adp and collagen. apyrase (atp diphosphohydrolase) activity was prominent, requiring ca2+ but not mg2+ and a ph optimum of 8.0. human as well as rabbit hosts developed a well delimited erythema, evident 2-3 min after initial probing and lasting for as long as 2 days. erythema, not accompanied by itching or swelling, developed in previously exposed hosts as well as in those not previously ex ...	1986	2870860
blood-finding strategy of a capillary-feeding sandfly, lutzomyia longipalpis.	salivary gland homogenates of adult female lutzomyia longipalpis inhibited platelet aggregation induced by adp and collagen. apyrase (atp diphosphohydrolase) activity was prominent, requiring ca2+ but not mg2+ and a ph optimum of 8.0. human as well as rabbit hosts developed a well delimited erythema, evident 2-3 min after initial probing and lasting for as long as 2 days. erythema, not accompanied by itching or swelling, developed in previously exposed hosts as well as in those not previously ex ...	1986	2870860
pharmacokinetics of t-2 toxin and its metabolite ht-2 toxin, after intravenous administration in dogs.	the pharmacokinetics of t-2 toxin and ht-2 toxin were investigated comparatively in five dogs, after iv administration of the toxins (0.4 mg/kg). t-2 toxin was very rapidly and almost completely biotransformed to ht-2 toxin (fm = 83.6 +/- 3.9%). the following mean pharmacokinetic parameters were determined in this study for t-2 toxin and ht-2 toxin, respectively: half-life 5.3 +/- 2.1 and 19.6 +/- 4.7 min, clearance 0.107 +/- 0.056 and 0.167 +/- 0.074 liters/min/kg, and volume of distribution 0. ...	1986	2870902
pharmacokinetics of t-2 toxin and its metabolite ht-2 toxin, after intravenous administration in dogs.	the pharmacokinetics of t-2 toxin and ht-2 toxin were investigated comparatively in five dogs, after iv administration of the toxins (0.4 mg/kg). t-2 toxin was very rapidly and almost completely biotransformed to ht-2 toxin (fm = 83.6 +/- 3.9%). the following mean pharmacokinetic parameters were determined in this study for t-2 toxin and ht-2 toxin, respectively: half-life 5.3 +/- 2.1 and 19.6 +/- 4.7 min, clearance 0.107 +/- 0.056 and 0.167 +/- 0.074 liters/min/kg, and volume of distribution 0. ...	1986	2870902
two bradykinin binding sites with picomolar affinities.	bradykinin (bk) and related peptides exert a wide range of effects on several organ systems. we have attempted to sort out these effects by studying the binding interaction of [3h]bk at the membrane level with in vitro receptor binding techniques. high specific activity [3h]bk and an enzyme inhibitor "cocktail" has enabled us to label two bk binding sites with different affinity and peptide specificity in several guinea-pig tissues. in the guinea-pig ileum the high-affinity site has an equilibri ...	1986	2871174
potent antagonism of escherichia coli, bacteroides ovatus, fusobacterium varium, and enterococcus faecalis, alone or in combination, for enteropathogens in anaerobic continuous flow cultures.	interactions between representative strains of four predominant resident bacteria of the human colon, escherichia coli, enterococcus faecalis, bacteroides ovatus, and fusobacterium varium, and strains of seven enteropathogens, yersinia enterocolitica, shigella flexneri, salmonella typhimurium, vibrio parahaemolyticus, v. cholerae serogroup non o1, staphylococcus aureus, and clostridium perfringens, were examined in studies with an anaerobic continuous flow culture system and medium resembling th ...	1986	2875188
the neurobiologic consequences of down syndrome.	trisomy of the whole or distal part of human chromosome 21 (hsa 21) (ts21) results in down syndrome (ds), which is characterized in part by mental retardation and associated neurological abnormalities. structural abnormalities observed frequently include reduced brain weight, decreased number and depth of sulci in the cerebral cortices, neuronal heterotopias, and reduced numbers of specific populations of neurons, such as granule cells, in the cerebral cortices. abnormalities in the structure of ...	1986	2875770
the fine structure of atypical ciliated cells in the human gastric epithelium.	gastric mucosa obtained from the body and pyloric portions of the human stomach were observed by light and transmission electron microscopy. ciliated cells were found in two of 18 subjects examined, one patient with gastric ulcer and the other one with gastric adenocarcinoma. the ciliated cells were found in epithelia at sites away from the main lesions. the tissues containing ciliated cells showed intestinal metaplasia combined with mild chronic gastritis in both cases. the epithelial layer fac ...	1986	2876543
evidence for a migratory capability of rat kupffer cells to portal tracts and hepatic lymph nodes.	the present study concerns the migratory ability of kupffer cells in the rat. phagocytic cells were labeled with colloidal carbon or gold, these markers being administered intravenously either into a tail vein, which resulted in generalized reticuloendothelial uptake, or in low dose into the portal vein, which produced uptake by kupffer cells alone. cells containing marker were observed in the portal tracts and in hepatic lymph nodes from 1 to 3 days after injection into the portal vein. the dir ...	1986	2876547
6,7-dichloro-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline . a structurally novel beta-adrenergic receptor blocking agent.	replacement of the catecholic hydroxyl groups of the beta-adrenergic receptor agonist 6,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline (trimetoquinol) with chloro substituents results in a compound with marked beta-adrenoceptor antagonist properties. this, therefore, parallels the similar transformation of the beta-adrenoreceptor agonist isoproterenol into the antagonist dichloroisoproterenol. in a test for inhibition of isoproterenol-induced enhancement of the rate of con ...	1986	2878080
phenotypic modification of human glioma and non-small cell lung carcinoma by glucocorticoids and other agents.	glucocorticoids are cytostatic for human glioma grown at a high cell density in cell culture. the effect is not cytotoxic, appears to involve a modification of the cell surface, and has been detected with methyl prednisolone, dexamethasone, and beta-methasone. glucocorticoids were also found to reduce malignancy-associated properties (plasminogen activator and endothelial mitogenesis) and enhance differentiation (glutamyl synthetase activity and high affinity gaba uptake). cytostasis was also se ...	1986	2879508
genetic analysis of the plasmid region controlling virulence in yersinia enterocolitica 0:9 by mini-mu insertions and lac gene fusions.	enteropathogenic strains of yersinia enterocolitica harbor a virulence plasmid (pyve plasmid) of 70 kilobases (kb) which specifies, at 37 degrees c, a calcium requirement for growth, autoagglutinability, resistance to the bactericidal activity of human serum, and the expression of outer membrane proteins (omp). some mutations suppress the calcium requirement for growth while others make the bacteria unable to grow at 37 degrees c, even in the presence of calcium. to analyse the genes involved in ...	1986	2854600
anti-surface antibodies to entamoeba histolytica and their role in complement lysis.		1986	2884957
differences in adhesiveness among type 1 fimbriate strains of enterobacteriaceae revealed by an in vitro hep2 cell adhesion model.	ten type 1 fimbriate strains of enterobacteriaceae were examined in an in vitro adhesion assay with hep2 epithelial cells. the range of hep2 cell adhesiveness, which was characteristic for each strain, was affected by motility, type 1 fimbriation and production of mannose sensitive haemagglutinin. nevertheless, not all type 1 fimbriate strains adhered well in this model. the findings are discussed with regard to the possibility that different type 1 fimbriate enterobacteria, though all are manno ...	1986	2881915
anti-hla-b27 antibodies in sera from patients with gram-negative bacterial infections.	several forms of seronegative polyarthritis are strongly associated with hla-b27, and a number of microorganisms have been implicated in the etiology of these diseases. to explain the association between hla-b27 and arthritis initiated by infection with these organisms, it has been proposed that there is immunologic cross-reactivity between the b27 molecule and 1 or more microbial antigens, and that this cross-reactivity leads to tolerance to such infection and/or to the production of anti-hla-b ...	1986	2421739
[effect of levamisole immunocorrective therapy on the dynamics of infectious o-antigenemia and the clinical manifestations in dysentery patients].	the immunocorrecting agent levamisole decreases the duration of infectious o-antigenemia, determined in the o-aggregate hemagglutination test and in the enzyme immunoassay, essentially accelerates the progress of convalescence and considerably decreases the possibility of the prolonged relapsing course of the disease in comparison with common methods of treatment.	1986	2422855
the response of the lung to foreign compounds that produce free radicals.		1986	2423026
the interaction of myelin basic protein with tubulin and the inhibition of tubulin carboxypeptidase activity.	tubulin carboxypeptidase was found to be inhibited by myelin basic protein in a concentration dependent manner. the inhibition was produced by the interaction between myelin basic protein with the substrate. as a consequence of this interaction, turbid insoluble aggregates were formed at either 5 degrees or 37 degrees c. the turbidity increased by increasing the myelin basic protein concentration and it reached a plateau at a molar ratio of myelin basic protein to tubulin dimer of about 6. at pl ...	1986	2423083
mechanism of rna redistribution of the 17,000g postmitochondrial supernatant after incubation at 37 degrees c and its impact on other related biochemical investigations.	evidence for stripping of ribosomes from rer in the 17,000g pms of the liver of the cancer patient was obtained in the 1.35 m region which is the region between the ser and rer. rna/protein ratios for the ser, 1.35 m region, and rer of 0.001, 0.083, and 0.235, respectively, for this liver are consistent with the degranulation of rer compared with rna/protein ratios for ser and rer from normal livers of 0.025 +/- 0.003, and 0.35 + 0.030, respectively. a rna/protein ratio of 0.235 was obtained for ...	1986	2423101
monoclonal antibodies specific for shigella flexneri lipopolysaccharides: clones binding to type i and type iii:6,7,8 antigens, group 6 antigen, and a core epitope.	monoclonal antibodies against the shigella flexneri lipopolysaccharide (lps) were generated in two fusions by using the myeloma cell line sp2/0 as a fusion partner with spleen cells from balb/c mice immunized with s. flexneri serotypes 1b and 3a bacteria. the antibodies were characterized by immunoblotting, enzyme-linked immunosorbent assay (elisa), hemagglutination, and coagglutination. four different types of monoclonal antibodies were isolated: antibodies specific for the core antigen of the ...	1986	2424839
shigella flexneri o-antigen epitopes: chemical and immunochemical analyses reveal that epitopes of type iii and group 6 antigens are identical.	in the present investigation we studied the nature of a shigella flexneri o antigen, the type iii antigen. no structural entity has yet been attributed to this antigen. phenol-water-extracted lipopolysaccharides (lpss) from all s. flexneri serotypes possessing either group 6 antigen or both type iii antigen and group 6 antigen were subjected to de-o-acetylation by weak alkali treatment. two-dimensional nuclear magnetic resonance spectra of serotype 3a native lps and de-o-acetylated lps were comp ...	1986	2424840
[nbt-test stimulation of neutrophilic granulocytes by bacterial preparations in healthy persons].		1986	2425131
changes in tonicity of perfusion medium cause prolonged opening of calcium channels of the rat chromaffin cells to evoke explosive secretion of catecholamines.	secretion of catecholamines (ca) from the isolated rat adrenal gland during and after perfusion with hypertonic krebs bicarbonate solution was studied. perfusion with hypertonic solution made by adding either 156 mm sodium chloride, choline chloride, arginine hydrochloride, sodium thiocyanate, or 312 mm sucrose had no effect on the spontaneous secretion of ca. the secretion evoked by splanchnic nerve stimulation (10 hz for 30 sec) and nicotine (2 micrograms) remained unaffected during perfusion ...	1986	2427669
human p85 glycoprotein bears three distinct epitopes defined by several monoclonal antibodies.	a glycoprotein of apparent mol. wt 85,000 isolated from human cells of b lineage by affinity to 50b4-igg immunoadsorbent was shown previously to express two spatially distinct epitopes identified with monoclonal antibodies 50b4 and 50e6 [letarte et al. (1985) molec. immun. 22, 113-124]. it is now demonstrated that the p85 glycoprotein is homologous to the f10-44-2 antigen, defined initially as a t-lymphocyte-granulocyte-brain antigen [dalchau et al. (1980) eur. j. immun. 10, 745-749], the a1g3 h ...	1986	2427941
hla-b27m1m2 and high immune responsiveness to shigella flexneri in post-dysenteric arthritis.	the heterogeneous hla-b27 antigen is closely associated with post-infectious or reactive arthritis (rea) and is comprised of two serologically defined variants: b27m1+m2+ and b27m1+m2-. an outbreak of dysentery (n = 120) caused by a shigella flexneri 2a strain, which possessed cell envelope antigens with epitopes resembling b27m2, resulted in five b27m1+m2+ patients with rea. the remaining seven b27m1+m2+, one b27m1+m2- and all but three b27-negative patients remained free of joint symptoms; the ...	1986	2428743
colonization, virulence, and mucosal interaction of an enteropathogenic escherichia coli (strain rdec-1) expressing shigella somatic antigen in the rabbit intestine.	the group factor 3,4 somatic antigen was transferred by recombination from a donor strain of shigella flexneri type 2a to the escherichia coli o15 rabbit pathogen strain rdec-1. a hybrid clone (7482-1-1) that expressed only the s. flexneri 3,4 somatic antigen and a second clone (7482-1-7) from the same mating mixture that expressed only the o15 somatic antigen were compared for virulence in rabbits. the 7482-1-1 strain produced diarrhea in 10% of rabbits versus 84% for the 7482-1-7 strain (p les ...	1986	2430026
induction in rats of lysine imbalance by dietary homoarginine.	the use of dietary homoarginine (ha) to produce a lysine imbalance was examined in young rats. ha, a basic amino acid analogue, was shown earlier to compete with lysine for transport across the blood-brain barrier. feeding a diet limiting in lysine and containing ha reduced food intake and growth; increasing dietary lysine content lessened these effects. a 3-fold increase in dietary lysine caused 10, 4, 20 and 50-fold increases in lysine concentrations in plasma, brain, liver and muscle, respect ...	1986	2430077
an activated harvey ras oncogene produces benign tumours on mouse epidermal tissue.	studies of the mutagenic action required for specific chemicals to produce benign or malignant tumours suggest that in mouse skin at least two genetic events occur before carcinoma formation. the isolation of an activated form of the c-rash gene from skin papillomas has provided evidence that this gene may be a target for the first mutation, which could constitute the initiating mutation in skin carcinogenesis. in vitro studies indicate that the v-rash gene of harvey murine sarcoma virus (ha-msv ...	1986	2430189
[synthesis of a repeating unit and the dimer of the repeating unit of the major chain of shigella flexneri o-antigen polysaccharide].	methyl glycoside of the tetrasaccharide glcnac(beta 1-2)rha(alpha 1-2)rha(alpha 1-3)rha, which represents a repeating unit of the basic chain of shigella flexneri o-antigenic polysaccharides, was synthesized using acylated monosaccharide synthons. a dimer of the repeating unit, octasaccharide [glcnac(beta 1-2)rha(alpha 1-2) rha(alpha 1-3)rha(alpha 1-3)]2-ome was obtained by trclo4-catalyzed condensation of two tetrasaccharide blocks.	1986	2430581
lack of correlation between hla-b27 like antigenic epitopes on shigella flexneri and the occurrence of reactive arthritis.		1986	2430745
[intergeneric antigenic relation of hafnia and shigella (s. flexneri and s. boydii) bacteria].	the o-antigenic relationships between hafnia and shigellae (s. flexneri and s. boydii) have been studied. for the first time the presence of antigenic relationship between hafnia o19, o4, o9, o33, o5, o16, o12, o7, o29, o28, o10, o32, o24, o25, o18, o1, o13, o3, o22, o30, o37, o14, o11, o25, o23, o21, o28, o16, o24, o8, o26, o27 and s. flexneri la, lb, 2a, 2b, 4a, 4b, 6, 5a, 5b, as well as between hafnia o10, o21, o35, o36, o9, o28, o8, o30 and s. boydii 1, 3, 6, 14, 2, 5, 2, 12 have been reveal ...	1986	2431565
in situ hybridization methods for the detection of somatostatin mrna in tissue sections using antisense rna probes.	in situ hybridization studies with [32p] and [3h] labelled antisense rna probes were undertaken to determine optimal methods of tissue fixation, tissue sectioning, and conditions of hybridization, and to compare the relative merits of the two different radioactive labels. the distribution of somatostatin mrna in neurons of rat brain using a labelled antisense somatostatin rna probe was employed as a model for these studies. the highest degree of sensitivity for in situ hybridization was obtained ...	1986	2435682
ostertagia ostertagi: excretory secretory chemotactic substance from infective larvae as cause of eosinophil locomotion.	the infective (third stage) larva of ostertagia ostertagi produced an excretory secretory substance that is chemotactic for bovine eosinophils. the eosinophil chemotactic substance was present in supernatants of larval cultures within 6 hr of incubation in eagle's minimum essential medium containing 25 mm n-2-hydroxyethylpiperazine-n'-2-ethanesulfonic acid. the substance responsible for eosinophil chemotaxis has activity in small amounts, a molecular weight (mw) greater than 2000, and is heat la ...	1986	3943588
ostertagia ostertagi: excretory secretory chemotactic substance from infective larvae as cause of eosinophil locomotion.	the infective (third stage) larva of ostertagia ostertagi produced an excretory secretory substance that is chemotactic for bovine eosinophils. the eosinophil chemotactic substance was present in supernatants of larval cultures within 6 hr of incubation in eagle's minimum essential medium containing 25 mm n-2-hydroxyethylpiperazine-n'-2-ethanesulfonic acid. the substance responsible for eosinophil chemotaxis has activity in small amounts, a molecular weight (mw) greater than 2000, and is heat la ...	1986	3943588
trichinella spiralis: newborn larval migration route in rats reexamined.	the route by which trichinella spiralis newborn larvae migrate from the small intestine to striated muscle was studied in inbred ao and random-bred sprague-dawley rats. newborn larvae were quantitatively recovered from the thoracic duct lymph, peritoneal cavity, and hepatic portal vein blood during the course of a primary infection with 4000 muscle larvae. the total recovery of newborn larvae assessed in this manner was compared with the number of muscle larvae in control rats receiving the same ...	1986	3943594
on dying more than one death.	death (with a capital d) can best be understood as a series of distinct but related deaths. for example, a pregnant woman was found to be brain-dead but her vital functions were artificially sustained for nine weeks until her fetus could be delivered, after which the machines were removed and she died a second, conceptually distinct death. this procedure is probably justifiable, but any legislation or policy regarding such cases should be flexible and should require consent.	1986	3957650
[secondary cutaneous mycoses caused by alternaria species].	analysis of 2 of our own cases of cutaneous alternariosis (ca) and 31 reported cases showed this mycosis to be nosologically heterogeneous. ca may present as an endogenous, multilocular form or as an exogenous, usually localized form. in the endogenous form of ca (11 cases), infection most probably occurs via the lung by inhalation. the highly dermatotropic organisms spread hematogenically to the skin where they cause the typical verruciform or granulomatous lesions. in the exogenous form (8 cas ...	1986	3957668
retinal constraints on orientation specificity in cat visual cortex.	most retinal ganglion cells (levick and thibos, 1982) and cortical cells (leventhal, 1983; leventhal et al., 1984) subserving peripheral vision respond best to stimuli that are oriented radially, i.e., like the spokes of a wheel with the area centralis at the hub. we have extended this work by comparing directly the distributions of orientations represented in topographically corresponding regions of retina and visual cortex. both central and peripheral regions were studied. the relations betwee ...	1986	3958796
[the systematic evaluation of medical procedures. apropos of the effectiveness of parallel medicine].		1986	3961360
response of dog tracheal stretch receptors to high frequency oscillations.	in eight dogs, anaesthetized and spontaneously breathing, we recorded from thin vagal filaments action potentials from eight slowly adapting receptors of the extrathoracic trachea. the extrathoracic trachea was cut longitudinally and the cut-ends of the cartilage corresponding to the site of the receptor in the trachealis muscle were stretched sinusoidally at frequencies from 0.5 to 39.5 hz. the number of spikes per cycle decreased with increasing frequency. at the highest frequency (40 hz), str ...	1986	3697539
spinal cord serotonin release and raised blood pressure after brainstem kainic acid injection.	the recently developed technique of in vivo dialysis has permitted us to make direct measurements of serotonin release in a specific region of the spinal cord and to relate this to changes in blood pressure elicited by chemical stimulation of the brainstem. in the present experiments we have shown that chemical stimulation of bulbospinal neurons in the region of the b3 cell group in the ventromedial medulla, causes an increase in the release of serotonin in the thoracic spinal cord and that this ...	1986	3697690
evidence for the presence of a novel biosynthetic pathway for norspermidine in vibrio.	enzymatic studies of the cell extracts of vibrio alginolyticus and v. parahaemolyticus provided evidence that there exists a novel biosynthetic pathway for norspermidine (nh2(ch2)3nh(ch2)3nh2), a major polyamine species. in this pathway, the schiff base formed between aspartic beta-semialdehyde and 1,3-diaminopropane is first reduced by a nadph-dependent enzyme to yield "carboxynorspermidine" (nh2(ch2)3nh(ch2)2ch(nh2)cooh), which is in turn decarboxylated by a pyridoxal phosphate dependent enzym ...	1986	3697846
rate of incorporation of [3h]thymidine in various tissues of the mouse. a basis for the evaluation of genotoxic effects of chemicals.	[3h]thymidine has been extensively used as a selective precursor to dna in studies on the kinetics of cell proliferation. we have become interested in measuring early inhibition of the dna synthesis in various organs of intact animals for detecting genotoxic properties of chemicals. such experiments should, for convenience and to achieve a large capacity, be performed in the simplest way possible. the present paper deals with some practical aspects on the use of [3h]thymidine in vivo. [6-3h]thym ...	1986	3698076
[cytogenetic activity of metabolites of pesticides representing different classes of chemical compounds].	the cytogenetic activity of some substances formed in agricultural plants during metabolism of pesticides of four classes of chemical compounds was studied in the culture of human peripheric blood lymphocytes. metabolites were shown either to have mutagenic properties similar to those of the initial compounds (ziramtetramethylthiourea, both being mutagens; captan-phthalimide, both possessing no cytogenetic activity) or to be considerably transformed in comparison with them as a result of deactiv ...	1986	3705167
somatotopic organization of motoneurons innervating the pronators, carpal and digital flexors and forepaw muscles in the dog: a retrograde horseradish peroxidase study.	central distribution of motor neurons innervating the individual forearm and forepaw muscle through the median and ulnar nerves was studied in the dog using the retrograde horseradish peroxidase (hrp) method. all hrp-labeled cells were seen ipsilaterally in restricted parts within the dorsolateral (dl) and retrodorsolateral nucleus (rdl) of the ventral horn at levels from the cranial tip of c7 to the cranial third of t2. the results showed that motoneurons situated more cranially supply the more ...	1986	3708348
increased collateralization of the cerebellothalamic pathway following neonatal hemicerebellectomy.	the postlesional reorganization of the cerebellothalamic cells was here studied using a multiple retrograde tracing technique. to this purpose, the cerebellothalamic cell population was investigated in 3 groups of adult rats: (a) cases hemicerebellectomized at birth; (b) cases hemicerebellectomized in adulthood; and (c) control unlesioned ones. in all of the groups the fluorescent tracers diamidino yellow and fast blue were injected bilaterally in the thalamus and the retrograde labeling obtaine ...	1986	3708349
the effect of amiodarone on thyroxine kinetics.	amiodarone was given by daily intraperitoneal injection (10 mg/kg body weight) to a group of 11 new zealand white rabbits. over 6 weeks there were significant increases (p less than 0.01) in plasma total t4 concentration (43 +/- 8 to 60 +/- 13 nmol/l; mean +/- 1 sd) and rt3 concentration (0.12 +/- 0.06 to 0.31 +/- 0.16 nmol/l) and a significant fall in total plasma t3 (2.3 +/- 0.3 to 1.7 +/- 0.2 nmol/l). the plasma clearance of t4 in rabbits treated with amiodarone for 6 weeks was significantly ...	1986	3708866
monoclonal antibodies to human eosinophil plasma membrane antigens enhance the secretion of eosinophil cationic protein.	this study was done to examine the nature of the membrane constituents involved in the secretion of eosinophil cationic protein (ecp) from human blood eosinophils. three mouse monoclonal antibodies were used, which showed greater binding to membrane antigens on activated, and light density eosinophils from patients with an eosinophilia, than on nonactivated or normal density eosinophils. all three antibodies (eon4, eon5 & eon6) stimulated normal density human eosinophils to secrete ecp, either a ...	1986	3708911
[effect of aevite and riboflavin on the electrolyte balance in the wall of the hepatic blood vessels in experimental toxic hepatitis].	the effects of aevite and riboflavin on electrolyte balance in the vessel wall were studied in toxic hepatitis in the cat. significant changes in the contents of na+, k+, ca2+ and mg2+ ions in the hepatic blood vessels were found in all periods of observation. the treatment of toxic hepatitis with aevite and riboflavin results in normalization of electrolyte balance of the vessel wall.	1986	3709781
[hemodynamic correlates of immobilization stress in the rat].	changes of the systemic and regional hemodynamics were studied in alert wistar rats during their immobilization. cardiac output and regional blood flows were measured with microsphere technique. the stress evoked 12% blood pressure increase, 30% cardiac output increase and 10% total peripheral vascular resistance decrease. blood flow was increased in skeletal muscles, in the heart and adrenal glands, whereas in the kidney and small intestine blood flow decreased.	1986	3709865
low-level lead exposure affects latent learning in the rat.	neonatal rats were administered intragastrically either lead acetate (50 mg pb/kg-bw) or an equal molar solution of sodium acetate at days 6, 9, 12, 15, and 18 postpartum. at 33 days of age, each animal began a training sequence to develop maze running skills. animals within each treatment group, i.e., lead exposed (pb), control vehicle (cv), and control nonhandled (cnh) were assigned randomly to either latent learning or open-field testing groups. the former individually explored a symmetrical ...	1986	3713959
reversible electroencephalogram changes associated with administration of baclofen in a quadriplegic patient: case report.	we present the case of a spastic quadriplegic who developed mental symptoms which resolved when his baclofen was discontinued. of interest was the presence of eeg abnormalities similar to those described in cats receiving this drug. these abnormalities, previously unreported in humans, resolved upon discontinuing baclofen therapy.	1986	3714292
leptospira hardjo agalactia in sheep.		1986	3716127
multifocal eosinophilic granuloma. response of a patient to etoposide.	a 60-year-old man with a history of diabetes insipidus presented with a left groin mass, leg edema, and retroperitoneal adenopathy. biopsy results of the involved lymph nodes were typical of eosinophilic granuloma. the patient was treated with etoposide and prednisone and had a complete regression of his lymphadenopathy and edema. this response suggests that etoposide may be a useful agent in the management of histiocytosis x.	1986	3719552
tumor metastasis-associated heparanase (heparan sulfate endoglycosidase) activity in human melanoma cells.	we discovered previously a tumor metastasis-associated heparan sulfate (hs)-degrading endoglycosidase in mouse melanoma cells that is a unique endo-beta-glucuronidase (heparanase) capable of specifically cleaving hs at intrachain sites (nakajima et al., j. biol. chem., 259 (1984) 2283. using unmodified- and chemically modified-hs and heparin substrates we demonstrate that human hs939 and mouse b16 melanoma cells possess a hs-degrading endoglycosidase of similar specificity. melanoma heparanase s ...	1986	3719568
detection of extravasation of antineoplastic drugs by microwave radiometry.	microwave radiometry may be used as a non-invasive technique for subcutaneous thermal sensing. this technique was capable of demonstrating extravasation of small volumes of fluids, including the antineoplastic agent adriamycin, when these fluids were administered at room temperature in dogs. the rate of temperature drop upon extravasation was proportional to the flow rate. it is feasible that microwave radiometry may be useful as an alarm system to reduce serious complications which often accomp ...	1986	3719569
serum immune response to shigella protein antigens in rhesus monkeys and humans infected with shigella spp.	the serum antibody response to proteins encoded by the virulence-associated plasmid of shigella flexneri was determined in monkeys challenged with virulent s. flexneri serotype 2a. with water-extractable antigen in an enzyme-linked immunosorbent assay, a significant increase in antibody titer against proteins from a plasmid-carrying, virulent strain of s. flexneri serotype 5 could be demonstrated in convalescent sera. there were minimal antibody titers against proteins from an avirulent (plasmid ...	1986	3721580
effect of thyroid hormones on plasma protein concentrations in man.	plasma concentrations of proteins secreted by the liver (prealbumin, haptoglobin, transferrin, ceruloplasmin, alpha 1-antitrypsin, antithrombin iii, and t4-binding globulin) and proteins mainly derived from endothelium [fibronectin, angiotensin-converting enzyme (ace), and factor viii-related antigen (f viii r:ag)] were measured in 27 hyperthyroid and 30 normal women. significantly increased plasma concentrations (p less than 0.01) of endothelium-associated proteins, including fibronectin, ace, ...	1986	3722331
salmonella hepatitis: detection of salmonella antigens in the liver of patients with typhoid fever.		1986	3722872
renal function in the fetal lamb: a chronic model to study physiological effects of ureteral ligation and deligation.	between 53 and 98 days of gestation 11 fetal lambs were subjected to unilateral ureteral ligation. in 8 fetuses re-exploration was performed 35 to 41 days after ligation. chronic catheterization of the obstructed kidney, bladder and fetal vascular system was used for analysis of physiological data. average creatinine clearance was 1.35 +/- 0.067 ml. per minute in the control kidney and 0.226 +/- 0.057 ml. per minute in the obstructed kidney after diversion. free water clearance, osmolar clearanc ...	1986	3723669
[clostridium difficile and its significance as an intestinal pathogenic bacterium].		1986	3725396
[associated vaccination of pigs against swine fever, erysipelas and aujeszky's disease].	tested was the simultaneous vaccination of pigs against swine fever, swine erysipelas, and aujeszky's disease. parallel to this experiment a second group of test pigs were treated with each of the three vaccines at twenty-day intervals. the effect of vaccination was assessed through clinical observations with the test groups and by challenging part of the animals with virulent strains of the swine fever and erysipelas agents. it was found that the successive application of the three vaccines at ...	1986	3727391
oxidative injury to the vascular endothelium.	in recent years, increasing clinical and experimental data have provided compelling evidence that neutrophil-derived oxygen radicals and their metabolites are important mediators of vascular endothelial injury. in this review, attention is directed toward in vitro, ex vivo, and in vivo experimental studies contributing to current understanding of mechanisms of oxyradical mediated endothelial damage. although these studies may have broad significance, they appear to have particular relevance to t ...	1986	3728559
low-molecular-weight proteinase inhibitor of human epidermis inhibiting papain and trypsin activity.	a low-molecular-weight proteinase inhibitor was isolated from human epidermal extracts by means of ultrafiltration, gel filtration and ion-exchange chromatography. on polyacrylamide gel electrophoresis (page), the isolated fraction exhibited a single band of activity at ph 9.4, and inhibitory activity against papain and trypsin was detected in this band. using sodium-dodecyl-sulphate page, the molecular mass of the inhibitor was estimated to be 2,200 daltons.	1986	3729540
[induction of cytochrome p-450 and b5 in hepatocyte subpopulations with phenobarbital].	hepatocytes isolated from intact and phenobarbital-treated rats were separated by ficoll discontinuous density gradient into five subpopulations. about 85% of the total cell number sedimented within the range of 1.044 to 1.126 g x cm-3. in intact rats, heavy hepatocytes contained about twice as much cytochrome p-450 and about 3 times as much cytochrome b5 as light cell population. phenobarbital induced cytochrome p-450 in all subpopulations, with a more pronounced increase observed in light hepa ...	1986	3730555
[induction of cytochrome p-450 and b5 in hepatocyte subpopulations with phenobarbital].	hepatocytes isolated from intact and phenobarbital-treated rats were separated by ficoll discontinuous density gradient into five subpopulations. about 85% of the total cell number sedimented within the range of 1.044 to 1.126 g x cm-3. in intact rats, heavy hepatocytes contained about twice as much cytochrome p-450 and about 3 times as much cytochrome b5 as light cell population. phenobarbital induced cytochrome p-450 in all subpopulations, with a more pronounced increase observed in light hepa ...	1986	3730555
vacant postsynaptic densities on supraoptic dendrites of adult rats diminish in number with chronic stimuli.	in earlier ultrastructural studies of the supraoptic nucleus in adult rats we noted "free" and incompletely covered postsynaptic densities (collectively referred to here as vacant postsynaptic densities) on dendritic shafts. free postsynaptic densities have been reported in other parts of the central nervous system of normal rodents. we investigated the possibility that physiological activation of the supraoptic cells, which produces changes in many aspects of their morphology, would alter the i ...	1986	3731249
structure and x-ray amino acid sequence of a bacteriochlorophyll a protein from prosthecochloris aestuarii refined at 1.9 a resolution.	the structure of the water-soluble bacteriochlorophyll a protein (bchl protein) from the green photosynthetic bacterium prosthecochloris aestuarii has been refined at 1.9 a resolution to a crystallographic residual of 18.9%. the refinement was carried out without knowledge of the amino acid sequence and has led to an "x-ray sequence". the structure consists of seven bchl molecules enclosed within a protein "bag" and the refinement supports the general conformation of the molecule described previ ...	1986	3735428
age related heterogeneity of lipopigments in human sympathetic ganglia.	the histochemical, autofluorescence and morphological characteristics of lipopigments accumulating with age in the human sympathetic neurons were studied. the spectral characteristics of the lipopigment autofluorescence change with age suggesting the accumulation of additional components in the residual bodies. this component is electron microscopically highly osmiophilic and stains also with silver staining. these changes may indicate the gradual melanization of the lipopigments due to auto-oxi ...	1986	3736128
[a method for registration of stomach movement of rabbits in chronic experiments].		1986	3738532
fragile papilloma (papillary adenoma) of the gallbladder. a cause of recurrent biliary colic.	this case study of a young man with a papillary adenoma of the gallbladder documents the potential for benign tumors of the gallbladder to present with symptoms of biliary colic. the case illustrates the mechanism by which free-floating, detached, tumor particles cause intermittent obstruction of the cystic duct, and it presents the attendant symptoms.	1986	3743976
comparison of the surface morphology of adult schistosoma japonicum (chinese, philippine and indonesian strains) by scanning electron microscopy.		1986	3744663
[euphorbia and high chapparall--hazardous pot plants in fashion].		1986	3747661
[campylobacter pyloridis--a cause of gastritis/ulcer?].		1986	3747663
pressure evaluation of the antireflux ability of the rat ureterovesical junction.	the bladder pressure necessary to cause vesicoureteral reflux (vur) was measured in 16 female rats. under general anesthesia, the ureters were exposed via an abdominal incision and a pressure catheter was placed near the ureterovesical junction. values of bladder distension and bladder pressure increase to cause vur were obtained by injecting isotonic saline in one ureter until vur in the opposite ureter was detected as a sudden pressure increase. after 5 min the same procedure was done on the c ...	1986	3750580
vitamin e deficiency in rabbits receiving a high pufa diet with and without a non-absorbable antioxidant. 1. incorporation of [1-14c]glycine into skeletal muscle proteins.	previous studies of metabolic changes in vitamin e-deficient animals were often difficult to interpret because the vitamin e-free, high pufa diets used in such studies may have contained high levels of peroxides. presumed effects of vitamin e deficiency could have been effects of peroxide consumption. addition of the non-absorbable polymeric antioxidant anoxomer to a semisynthetic vitamin e-free diet containing cod liver oil was found to suppress peroxide formation. nevertheless, this diet produ ...	1986	3751156
[reactogenic properties and immunogenicity of measles and mumps vaccines when used by different procedures].	in the controlled epidemiological trial the reactogenic and immunogenic properties of live measles vaccine (lmv) and live parotitis vaccine (lpv) were evaluated in identical groups of children immunized in accordance with different schedules: only lmv or lpv, the injection of these preparations mixed in one syringe or with the use of separate syringes, or at an interval of 3 months. the highest number of febrile reactions, rash and catarrhal symptoms was registered among children immunized with ...	1986	3751401
[reactogenic properties and immunogenicity of measles and mumps vaccines when used by different procedures].	in the controlled epidemiological trial the reactogenic and immunogenic properties of live measles vaccine (lmv) and live parotitis vaccine (lpv) were evaluated in identical groups of children immunized in accordance with different schedules: only lmv or lpv, the injection of these preparations mixed in one syringe or with the use of separate syringes, or at an interval of 3 months. the highest number of febrile reactions, rash and catarrhal symptoms was registered among children immunized with ...	1986	3751401
1,25-dihydroxyvitamin d3 treatment results in increased choline acetyltransferase activity in specific brain nuclei.	to better understand the role of 1,25-dihydroxyvitamin d3 [1,25-(oh)2d3] in brain function, the level of calcium-binding protein (cabp) and the activities of choline acetyltransferase (cat) and monoamine oxidase were measured in discrete brain nuclei of vitamin d-deficient and -replete male rats. the nuclei sampled were those in which receptors for 1,25-(oh)2d3 and/or vitamin d-dependent cabp have been localized. significant elevations in cat activity were found in the arcuatemedian eminence and ...	1986	3753932
the effect of arylazido aminopropionyl atp (anapp3) on inhibition of pelvic nerve evoked contractions of the cat urinary bladder.	previously reported work has provided evidence that arylazido aminopropionyl atp (anapp3), a p2-receptor antagonist, blocks the effects of atp and other purine analogs, in the urinary bladder of the cat. this antagonism appeared limited to those effects mediated by p2-receptors, such as contraction of the urinary bladder. however, it was noted that anapp3 did alter the effects of adenosine, mediated through p1-receptors, in some preliminary experiments. a series of experiments was undertaken to ...	1986	3753940
direct retinal pathways to the limbic thalamus of the monkey.	tritiated proline, horseradish peroxidase (hrp), and wheat germ agglutinin conjugated to hrp (wga-hrp) were used as anterograde tracers in the monkey to reveal visual pathways. after intravitreal injections, three separate, direct routes of labeled retinal axons were followed to the thalamus. these routes eventually converged to innervate the lateral dorsal and anterodorsal thalamic nuclei. thus, retinal input may reach the posterior cingulate cortex after a single synapse in lateral and anterio ...	1986	3754221
[3h]pirenzepine and (-)-[3h]quinuclidinyl benzilate binding to rat cerebral cortical and cardiac muscarinic cholinergic sites. i. characterization and regulation of agonist binding to putative muscarinic subtypes.	the binding and regulation of selected muscarinic agonists to putative subtypes in rat cerebral cortex and heart were studied. parallel inhibition studies of [3h]pirenzepine ([3h]pz) and (-)-[3h]quinuclidinylbenzilate [(-)-[3h]qnb]-labeled membranes were done with and without 30 microm guanyl-5'-yl imidodiphosphate [gpp(nh)p] at 25 degrees c in 10 mm na-k-phosphate buffer which enhances pz binding affinity and in modified krebs-phosphate buffer, which mimics physiological conditions. classical a ...	1986	3754580
ketoconazole-induced reduction in serum 1,25-dihydroxyvitamin d.	the antimycotic agent ketoconazole is known to inhibit several cytochrome p450-dependent enzymes involved in the biosynthesis of steroid hormones from cholesterol. since 1,25-dihydroxyvitamin d is also a sterol synthesized by cytochrome p450-dependent enzymes, we assessed whether ketoconazole would lower serum 1,25-dihydroxyvitamin d levels. in nine normal men, administration of ketoconazole for 1 week in doses of 300-1200 mg/day led to a dose-dependent reduction in serum 1,25-dihydroxyvitamin d ...	1986	3755445
how a child's blood pressure is related to psychological influences. some results with r. zazzo's bestiary test.	the purpose of the study was to investigate the relationships between some psychological characteristics and blood pressure. we used the bestiary test which gives an impression of the child's psychological characteristics and his way of coping with personal conflicts. the test was applied to 766 children between the ages of 4-10 years. by discriminant analysis we established relations between systolic blood pressure, and the responses to the test. by correspondence analysis we found that hyperte ...	1986	3757284
uptake of 450191-s, a 1h-1,2,4-triazolyl benzophenone derivative, in the everted sac of rat small intestine: role of intestinal aminopeptidases.	5-[(2-aminoacetamido)methyl]-1-[p-chloro-2-(o-chlorobenzoyl)phenyl ]-n,n-dimethyl-1 h-1,2,4-triazole-3-carboxamide hydrochloride dihydrate (450191-s), a sleep inducer, is a ring-opened derivative of 1,4-benzodiazepine and has been reported to be activated by intestinal aminopeptidases in a step of absorption. in this study, we investigated the role of the intestinal aminopeptidases in the uptake of 450191-s by the intestine by using various aminopeptidase inhibitors in everted sacs of rat small ...	1986	3761138
myocardial ischemia stimulates catecholamine synthesis and catabolism in the dog adrenal medulla.	the effects of regional ischemia of the myocardium upon metabolism and catabolism of catecholamines were studied in the dog adrenal medulla. regional ischemia was induced by ligating a small branch of the left anterior descending coronary artery for 1 or 24 hours. sham-operated controls were run in parallel. coronary ligation for 24 hours resulted in a decrease in the level of epinephrine and an increase in the level of dopamine in the adrenal medulla, and also resulted in an increase in the act ...	1986	3761566
the complex nature of food antigens: studies of cross-reacting crustacea allergens.		1986	3767090
[establishment of a spontaneously transformed human fetal lung cell line and its biological characteristics].	a spontaneously transformed human fetal lung cell line (hflt) was derived from a human fetal lung diploid fibroblast cell line (2bs) by continuous culture. the biological characteristics of this cell line were studied and compared with those of 2bs cells. accompanying the morphological alteration, the growth rate of the transformed cell was accelerated and the maximum cell density was increased. the anchorage-independent growth was shown by its ability to form colonies in soft agar. the collagen ...	1986	3769747
widowhood, sex, labor force participation, and the use of physician services by elderly adults.	this paper investigated the relationships of widowhood, sex, and labor force participation with the use of ambulatory physician services by elderly adults. data on 18,441 individuals aged 55 and over were taken from the 1978 health interview survey. hierarchical regression results indicated that although these three factors are related to physician utilization at the zero- and first-partial levels, only sex remained significant when their two- and three-way interactions and other variables from ...	1986	3772057