Publications

basal serum gastrin concentrations before and after eradication of helicobacter pylori infection measured by sequence specific radioimmunoassays.	helicobacter pylori infection of the antral mucosa is responsible for an increase in basal and stimulated serum gastrin. in the present study we have investigated whether gastritis induced by h. pylori is responsible for abnormalities in the processing of gastrin in dyspeptic patients.	1994	7532445
helicobacter pullorum sp. nov.-genotype and phenotype of a new species isolated from poultry and from human patients with gastroenteritis.	campylobacter-like organisms were isolated from the liver, duodenum and caecum of broiler and layer chickens, and from humans with gastroenteritis. they formed a unique dna homology group and a polyphasic taxonomic analysis was made of 16 strains. analysis of the nucleotide sequence of the 16s rrna gene from seven of the strains identified them as belonging to a single species, within the genus helicobacter. this conclusion was supported by the studies of relative dna homology and of total prote ...	1994	7533595
[what new is there in drug therapy? in the years 1992-1994. 2].		1994	7533922
[characterization of clonal b-cell populations in gastric malt lymphomas and chronic gastritis by means of the polymerase chain reaction].	amplification of the cdr3-region of the immunoglobulin (ig) heavy chain gene rearrangement by means of the pcr yielded clonal products in the tumor dna of 12 high or low grade gastric b-cell lymphomas of malt-type. in four cases, additional clonal bands were found in different areas of tumor free mucosa diagnosed as chronic gastritis associated with helicobacter pylori (hp). most of these small clonal populations were found to share identical dna sequences in their clone specific cdr3-regions wi ...	1994	7534001
genetic organization and enzymatic activity of a superoxide dismutase from the microaerophilic human pathogen, helicobacter pylori.	helicobacter pylori (hp) is a microaerobic human pathogen that has been implicated as a factor in the development of chronic type-b gastritis, gastric ulcers and gastric carcinoma. the enzyme superoxide dismutase (sod), a major defense mechanism against oxidative damage, catalyzes the breakdown of superoxide radicals to hydrogen peroxide and dioxygen. a search for sod genes in hp, employing pcr, revealed that this bacterium contained at least one sod gene. we cloned and sequenced a sod from this ...	1994	7515365
the significance of lymphoid follicles in the interpretation of gastric biopsy specimens.	lymphoid follicles are a common feature of helicobacter pylori-associated gastritis. recently, by using gastric mapping, we demonstrated lymphoid follicles in all of 62 patients with h pylori infection. this study was designed to address (1) the prevalence of lymphoid follicles in routine gastric biopsy specimens, (2) their correlation with chronic active gastritis, and (3) their predictive value with respect to h pylori infection. slides from 174 patients whose gastric biopsy findings carried a ...	1994	7517659
helicobacter pylori potentiates histamine release from rat serosal mast cells induced by bile acids.	in the present study we have experimentally addressed the effects of helicobacter pylori on the bile acid capability of histamine release. bile acids alone were confirmed to be able to induce in vitro histamine release from rat serosal and mucosal mast cells. on the contrary, no significant histamine release was obtained when incubating any helicobacter pylori preparations alone with mast cells. however, histamine release induced by bile acids was significantly enhanced, without any significant ...	1994	7517817
helicobacter pylori activates gastric mucosal mast cells.		1994	7517819
importance of the fiberoptic endoscope cleaning procedure for detection of helicobacter pylori in gastric biopsy specimens by pcr.	a 16s ribosomal dna-based pcr appeared to be a sensitive test for the detection of infection by helicobacter pylori in 31 patients when compared with culturing and histological and serological techniques. for five patients, pcr was the only test with a positive result. h. pylori dna was also found in gastrointestinal equipment even after standard intensive combined manual and machine cleaning. we therefore conclude that a reliable validation of pcr for the detection of h. pylori in gastric biops ...	1994	7517952
an intervening sequence (ivs) in the 16s rrna gene of the eubacterium helicobacter canis.	pcr amplicons enlarged by approximately 250bp were generated from the 16s rrna (rrs) genes of certain strains of the recently described helicobacter species, h. canis. the dna sequence of the rrs gene of one such strain was determined, and it was shown that an intervening sequence (ivs) of 235bp followed nucleotide 199 in the rrs sequence. in four other h. canis strains, identical or similar ivss were found, always at the same location in the rrs gene. the secondary structures of the rna transcr ...	1994	7518076
use of pcr with feces for detection of helicobacter pylori infections in patients.	pcr was performed for the detection of helicobacter pylori in feces from 24 patients with proven infections. several precautions were taken to overcome possible inhibition of pcr with feces. in the first 12 patients, feces were examined shortly after endoscopy. in another group of 12 patients, who were treated during 2 weeks with omeprazole (40 mg each day) to increase gastric ph, feces were examined as well. h. pylori target dna could not be detected in the stools of any of the 24 infected pati ...	1994	7519630
[clinical diagnosis of helicobacter pylori infection in adults].		1994	7519881
[clinical diagnosis of helicobacter pylori infection in the child].		1994	7519882
[from campylobacter to helicobacter].		1994	7519883
[ulcer. new approach to the problem].	the paper deals with the issues of ulcerogenesis, including the value of helicobacter pylori (hp) as one of the etiological and pathogenetic factors of ulcer diseases. the data available in the literature and the author's own findings have allowed the author to study the spread of hp infection. there is a higher incidence of ulcer disease among endoscopists than that in therapeutists and inhabitants in moscow. light and electron microscopies have demonstrated abnormal changes in the gastric muco ...	1994	7519920
evolutionary relationships among eubacterial groups as inferred from groel (chaperonin) sequence comparisons.	the essential groel proteins represent a subset of molecular chaperones ubiquitously distributed among species of the eubacterial lineage, as well as in eukaryote organelles. we employed these highly conserved proteins to infer eubacterial phylogenies. groel from the species analyzed clustered in distinct groups in evolutionary trees drawn by either the distance or the parsimony method, which were in general agreement with those found by 16s rrna comparisons (i.e., proteobacteria, chlamydiae, ba ...	1994	7520741
phylogeny of helicobacter isolates from bird and swine feces and description of helicobacter pametensis sp. nov.	previously, nine fecal isolates from wild birds and a domestic swine were identified as helicobacters by phenotypic characterization and reaction with a helicobacter genus-specific dna probe. these isolates fell into three biotypes by analysis of phenotypic traits. to further characterize these isolates, full 16s rrna sequences were determined for strains representing each biotype, and sequence comparison indicated that the strains represented three novel, phylogenetically defined helicobacter s ...	1994	7520743
binding of vitronectin and plasminogen to helicobacter pylori.	we have studied how some extracellular matrix proteins, fibronectin, fibrinogen, collagen type i and type iv, plasminogen and vitronectin bind to helicobacter pylori. radiolabelled vitronectin and plasminogen bound to the haemagglutinating h. pylori strain 17874 at a high level (53% and 32%, respectively), type iv collagen showed an intermediate level of binding (16%), while binding by 125i-labelled fibrinogen, fibronectin and collagen type i remained at a low level (5-7%). both 125i-vitronectin ...	1994	7522734
interaction of cells of helicobacter pylori with human polymorphonuclear leucocytes: possible role of haemagglutinins.	the interaction of fluorescein isothiocyanate (fitc)-labelled cells of helicobacter pylori with human polymorphonuclear leucocytes (pmns) was studied. two strains with surface haemagglutinins expressing different receptor specificity were used in order to decide if cell surface haemagglutinins of h. pylori may play a role in lectin-mediated binding to/uptake by phagocytes: (1) strain 17874 (nctc 11637) which expresses sialic acid-specific haemagglutinin; and (2) strain 17875 (nctc 11638) which e ...	1994	7522735
characterization and presumptive identification of helicobacter pylori isolates from rhesus monkeys.	we characterized 38 helicobacter isolates, including 22 from gastric biopsy samples obtained from 14 rhesus monkeys and single isolates from 16 monkeys in a different colony. biochemical profiles of these isolates were nearly identical to that of helicobacter pylori atcc 43504. restriction fragment length polymorphism (rflp) analysis indicated that each infected monkey harbored one to four strains. the 17 rflp types found among these 22 isolates differed from all seven rflps found among the othe ...	1994	7523441
coccoid forms of helicobacter pylori in the human stomach.	helicobacter pylori (hp) may transform from helical bacillary forms to coccoid forms after several days' in vitro incubation. the authors examined 111 consecutive gastrectomy specimens for the presence of coccoid forms of h pylori. tissues from 64 stomachs (57.7%) showed colonization by h pylori, including 49 cases (76.6%) of adenocarcinoma, 14 cases (21.9%) of benign peptic ulcer, and 1 case (1.6%) of malignant lymphoma. of these, coccoid forms of h pylori were identified in 53 cases (82.8%). i ...	1994	7524304
omeprazole. an update of its pharmacology and therapeutic use in acid-related disorders.	omeprazole, a gastric acid pump inhibitor, dose-dependently controls gastric acid secretion: the drug has greater antisecretory activity than histamine h2-receptor antagonists. omeprazole 20 to 40 mg/day is more effective than histamine h2-receptor antagonists in the short term treatment of duodenal ulcer, gastric ulcer and reflux oesophagitis. available data suggest that omeprazole 10 to 40 mg/day is also more effective than ranitidine in the maintenance therapy of duodenal ulcer and reflux oes ...	1994	7525198
enhanced gastric nitric oxide synthase activity in duodenal ulcer patients.	nitric oxide, the product of nitric oxide synthase in inflammatory cells, may have a role in tissue injury through its oxidative metabolism. nitric oxide may have a role in the pathogenesis of duodenal ulcer and may be one of the mechanisms responsible for the association between gastric infection with helicobacter pylori and peptic disease. in this study, calcium independent nitric oxide synthase activity was detected in human gastric mucosa suggesting expression of the inducible isoform. in 17 ...	1994	7525417
in situ hybridisation for the identification of helicobacter pylori in paraffin wax embedded tissue.	a method for identifying helicobacter pylori using a non-isotopic in situ hybridisation technique is described. a probe generated by polymerase chain reaction (pcr) with primers directed against parts of the helicobacter pylori 16srrna sequence was used. paraffin wax embedded gastric biopsy specimens from patients with and without gastritis were hybridised with the probe, and the method was shown to be sensitive and specific for h pylori.	1994	7525660
serum antibody response to the superficial and released components of helicobacter pylori.	superficial and released components were extracted from six selected helicobacter pylori strains. the protein and antigenic profiles of these extracts were representative of the profiles found most frequently among the clinical strains and included major peptidic fractions at 19, 23.5, 57, 68, 76, 118, and 132 kda and major antigens at 68, 57, and 23.5 kda. immuno-cross-reactions were seen with a hyperimmune rabbit serum to campylobacter fetus but not with sera to campylobacter jejuni or salmone ...	1994	7496968
correlation between serological and mucosal inflammatory responses to helicobacter pylori.	in 82 patients who underwent gastroduodenoscopy, acute and chronic gastric mucosal inflammation was scored for severity, and systemic humoral immune responses to helicobacter pylori antigens were assessed by enzyme-linked immunosorbent assays. on the basis of culture, gastric histology, and serologic evaluation, 33 patients were classified as h. pylori infected and 36 were classified as uninfected. thirteen patients had negative cultures and stains but were seropositive and were analyzed separat ...	1994	7496970
inflammation, acid and ulcers.	chronic active type b gastritis is invariably the result of helicobacter pylori infection and is an important factor in duodenal ulcer disease. the actions of mediators produced (a protein factor, a lipid soluble "pore-forming factor" and urease) or induced (immune/inflammatory cell mediators) by this bacterium on the control of gastric acid secretion are currently being investigated. these studies are reviewed in light of our current knowledge of the physiological control of gastric acid secret ...	1994	7502522
therapeutic applications of vagotomy.	the treatment of the peptic ulcer disease involves several options. the present discussion deals with the long-term management with emphasis on the application of vagotomy. eradication of helicobacter pylori is the treatment of choice in ordinary peptic ulcer patients. exceptions are non-steroidal, anti-inflammatory drug-induced ulcers and the zollinger-ellison syndrome. failures to eradicate h. pylori in old or unfit duodenal ulcer patients and most gastric ulcer patients will lead to intermitt ...	1994	7502524
gastric acid secretion: activation and inhibition.	peripheral regulation of gastric acid secretion is initiated by the release of gastrin from the g cell. gastrin then stimulates the cholecystokinin-b receptor on the enterochromaffin-like cell beginning a calcium signaling cascade. an exocytotic release of histamine follows with concomitant activation of a c1- current. the released histamine begins the h2-receptor mediated sequence of events in the parietal cell, which results in activation of the gastric h+/k+ - atpase. this enzyme is the final ...	1994	7502535
morphological aspects of the cytotoxic action of helicobacter pylori.	to morphologically investigate the cytotoxic action of helicobacter pylori on gastric mucosal cells.	1994	7537615
detection of infectious disease agents in tissue by immunocytochemistry.	1. immunocytochemical procedures have played an increasingly larger role in the identification of infectious disease agents in tissue sections owing to the increased availability and specificity of antibody reagents, the great sensitivity of the methods, and the relative facility with which the studies are performed. 2. immunocytochemical methods can be applied to routine formalin-fixed tissue for the detection of infectious agents such as viruses, bacteria, fungi, and protozoa among other micro ...	1994	7550001
[cause-targeted treatment of ulcer disease].		1994	7555798
helicobacter pylori in barrett's esophagus and in normal or inflamed esophageal mucosa: a retrospective study.	to investigate on the presence and significance of helicobacter pylori (hp) in barrett's mucosa, esophageal biopsy specimens from 34 patients with columnar-lined epithelium were retrospectively examined. the incidence of colonization was compared with that observed in a control group of 76 subjects with normal esophageal mucosa or moderate esophagitis. three of the 34 barrett's specimens were hp-positive and only 1 of these showed evidence of inflamed mucosa (p = ns). we do not find in this stud ...	1994	7480972
another one bites the dust: an infectious origin for peptic ulcers.		1994	9384861
response: psychosomatic medicine rides again.		1994	9384862
formulary management of antiulcer drugs: clinical considerations.	peptic ulcer disease (pud) is thought to result from an imbalance between aggressive (excessive) {especially gastric acid and pepsin} and protective (diminished) factors (gastric mucus and bicarbonate, prostaglandins and others) in the stomach. recent attention has focused on the role of helicobacter pylori as a cause of chronic active gastritis and a pathogenic factor in pud. antiulcer medications with proven efficacy in the treatment of acute pud include histamine 2 (h 2)-receptor antagonist ...	1994	10146896
ranitidine: a pharmacoeconomic evaluation of its use in acid-related disorders.	ranitidine is a histamine h 2-receptor antagonist which, on the basis of its well established tolerability and efficacy profile, has been widely prescribed for the treatment of ulcer disease and mild to moderate reflux oesophagitis. however, the advent of more powerful gastric acid inhibitors (e.g. acid pump inhibitors) and the realisation of the role of helicobactor pylori infection in duodenal ulcer disease could have considerable clinical and economic implications for the use of ranitidine ( ...	1994	10147354
helicobacter pylori-induced diarrhea ileogastrostomy.	a retrospective study of all ileogastrostomy procedures (n = 26) performed in 1993 by one surgeon (igmc) was carried out to investigate the hypothesis that helicobacter pylori may be implicated in certain severe cases of postoperation nausea and diarrhea. ten of 26 persons (38.5%) displayed nausea and notable diarrhea (greater than or equal to ten bowel movements per day), seven of which warranted upper gi investigation. one hundred per cent (seven of seven) of these persons were found to posses ...	1994	10742790
helicobacter pylori-associated gastritis and the ascorbic acid concentration in gastric juice.	patients infected with helicobacter pylori have abnormally low ascorbic acid concentration in gastric juice. low vitamin c intake and helicobacter pylori infection have been related to an increased risk of gastric carcinoma. this report examines the association between ascorbic acid and helicobacter pylori in patients referred for upper gastrointestinal endoscopy. elevated gastric ph and the damage to the gastric surface epithelium were inversely associated with the ascorbic acid concentration i ...	1994	11304911
helicobacter pylori comb. nov. exhibits facultative acidophilism and obligate microaerophilism.	modified brucella broth medium was used to study the growth of helicobacter pylori at varied phs and partial pressures of oxygen and to determine the effect of urea on culture ph. our findings suggested that the phs of the media remained stable with or without urea and that h. pylori showed facultative acidophilism and obligate microaerophilism.	1994	16349304
laparoscopic management of complications of peptic ulcer disease.	laparoscopic treatment of intractable duodenal ulcers is intended for the treatment of patients who do not heal after a trial of intensive regimen of medication such as h2 blockers and/or therapy aimed at eradication of helicobacter pylori. patients in a category who are helicobacter-negative can be offered a laparoscopic treatment of their ulcer by vagotomy. patients who have early relapses on stopping medical treatment are also candidates for vagotomy. complications of the disease, such as ble ...	1995	21400421
[helicobacter pylori infection: the efficacy of a short course of azithromycin and fleroxacin treatment.]	the aim of this open pilot study was to assess the efficacy of a short course of fleroxacin and azithromycin in the treatment of helicobacter pylori infection. seventeen patients were included. all had h. pylori infection confirmed by urease test and culture. eight patients had non-ulcer dyspepsia, 8 had duodenal ulcer and 1 had gastric ulcer. the patients were given omeprazole 40 mg on days 1-14, fleroxacin 400 mg on days 7-14 and azithromycin 500 mg on days 7 and 8. side effects were assessed ...	1995	20065488
[helicobacter pylori infection: the efficacy of bismuth-tetracyclin-metronidazole triple therapy in patients with duodenal ulcer.]	the aim of the study was to assess the efficacy of two bismuth-tetracyclin-metronidazole "triple therapy" regimes for helicobacter pylori and their effect of eradication of the bacteria on duodenal ulcer disease. eighty-two patients (52 males and 30 females, mean age 49 years) with a history of recurrent duodenal ulcer and h. pylori postitive gastritis were included in the study. treatment i, 35 patients, received colloid bismuth subcitrate (de-nol(r)) 120 mg q.i.d, tetracyclin 500 mg q.i.d. and ...	1995	20065489
varioliform gastritis - an endoscopic presentation form of helicobacter pylori.		1995	17588999
helicobacter pylori-associated chronic antral gastritis in kuwait - a histopathological study.	in order to study the causal relationship between helicobacter pylori (hp) and various inflammatory reactions in gastric antral mucosa, we have reviewed 268 endoscopic gastric biopsies in the department of pathology of mubarak al-kabeer teaching hospital in kuwait. of the 219 hp-positive biopsies, 95.4% showed chronic gastritis (cg), 59.8% active chronic gastritis (acg) and 78.5% lymphoid hyperplasia (lh). the prevalence of lh, cg or acg, either alone or in combination, increased with increasing ...	1995	17589012
synthesis, characterization and molecular structures of some bismuth(iii) complexes with thiosemicarbazones and dithiocarbazonic acid methylester derivatives with activity against helicobacter pylori.	the reactions of bismuth(iii) nitrate pentahydrate and bismuth(iii) chloride with heterocyclic thiosemicarbazones and derivatives of dithiocarbazonic acid methylester were used to synthesize the respective bismuth(iii) complexes, which could be divided into five groups d-h because of their stoichiometrical properties and their molecular structures. the molecular structure and the near coordination sphere of the bismuth(iii) central atom of four representative compounds were determined by single- ...	1995	18472778
h. pylori infection and gi disease: what critical care physicians need to know. who should be tested for h. pylori? when is treatment needed?	helicobacter (campylobacter) pylori infection has emerged as a major cause of gastritis, peptic ulcers, and gastric malignancies. not all patients with h. pylori infection require treatment; however, for those with ulcer disease (particularly those with bleeding), antibiotic therapy can be curative. to confirm infection (or its eradication), use the rapid urease assay, serologic examination or, when available, the urea breath test. treatment options include triple therapy (with bismuth subsalicy ...	1995	10150401
the cost effectiveness of helicobacter pylori eradication versus maintenance and episodic treatment in duodenal ulcer patients in sweden.	this study compares the cost effectiveness of helicobacter pylori eradication and conventional treatment in duodenal ulcer patients treated by a general practitioner. using a markov chain approach, swedish cost data and a study period of 5 years, we conclude that h. pylori eradication with omeprazole and appropriate antibiotics is a cost-effective alternative compared with both maintenance and episodic treatment. of the patients entering the eradication strategy, most are cured and will have no ...	1995	10160075
[evaluation of treatment effectiveness for helicobacter pylori infections in children].	an assessment was performed of the effectiveness of treatment of helicobacter pylori infection and coexisting diseases in children with two and three drugs. a high percent of bacterial eradication and cure of the coexistent conditions were achieved particularly in the group of children treated with three drugs.	1995	9638197
a comparative study between rapid urease (modified), clo test, culture and histopathological examination for helicobacter pylori in patients with acid peptic diseases.	a modified rapid urease test developed by us was evaluated as a screening test for helicobacter pylori (h. pylori) during and endoscopy survey on patients with acid peptic diseases (apd) and non ulcer dyspepsia (nud). this was compared with commercially available clo (campylobacter like organism) test, culture and histopathological examination. the modified rapid urease test gave a sensitivity of 89.83% and a specificity of 100%, when compared to 95% sensitivity and specificity for commercially ...	1995	9726142
[helicobacter pylori and upper digestive disease at the main hospital of dakar. study apropos of 105 consecutive endoscopies].	gastro-duodenal ulcer is a very frequent disease in senegal and helicobacter pylori (hp) being an ubiquitarian germ infects people living in developing countries in an over-early way and this most frequently. we have realized a prospective study dealing with 105 adult patients sent to hospital principal's endoscopy center. we were searching for hps into three different methods which are as follows: using ordinary slats, clo-test, histological process. the results have confirmed the existence of ...	1995	9827080
cat owners' risk of acquiring a helicobacter pylori infection.	in order to obtain information as to whether or not domestic cats are a significant reservoir for human helicobacter pylori infection, h. pylori antibodies were determined in 59 members of cat protection clubs and in an age- and sex-matched control group. using four different assay systems, the prevalence rates of h. pylori antibodies in the cat owner group compared to the control group were 29% and 34%, respectively (pyloriset dry), 27%/42% (pyloriset eia-g), 14%/29% (pyloriset eia-a), and 37%/ ...	1995	9810653
peptic ulcer disease in adolescents.	this article discusses the pathophysiology, diagnosis, and treatment of peptic ulcer disease in adolescents, focusing on the recently recognized pathogen, helicobacter pylori, as an etiologic agent in this disorder.	1995	10358321
occurrence and significance of helicobacter pylori infection after gastric surgery.	occurrence and significance of helicobacter pylori (hp) infection in patients having undergone partial and total gastric resection was studied. forty-nine patients after gastric resection with billroth i and ii operation (28 patients due to ulcer and 21 patients due to gastric cancer), and 8 patients with total gastrectomy due to gastric cancer were selected. in addition, 40 patients with active peptic ulcer disease, 32 patients suffering from gastric cancer, and 28 patients with non-ulcer dyspe ...	1995	9262715
expression of cytokine mrna in gastric mucosa with helicobacter pylori infection.	we have studied the cytokine production patterns in gastric mucosal biopsy specimens with and without the helicobacter pylori infection, using a reverse transcription-polymerase chain reaction (rt-pcr) method capable of detecting low levels of specific mrna.	1995	9053967
[prevalence of helicobacter pylori in tunisia in asymptomatic controls, non-ulcer dyspepsia and duodenal ulcer. a prospective study of 183 cases].		1995	9506161
analysis of antral biopsy specimens for evidence of acquired mucosa-associated lymphoid tissue in hiv1-seropositive and hiv1-negative patients.	there is conflicting evidence concerning the prevalence of helicobacter pylori gastritis in hiv1-infected patients. furthermore, a possible influence of immunodeficiency on the acquisition of mucosa-associated lymphoid tissue (malt) in the antral mucosa remains to be elucidated.	1995	7481524
cluster analysis of helicobacter pylori genomic dna fingerprints suggests gastroduodenal disease-specific associations.	helicobacter pylori infection is now accepted as the most common cause of chronic active gastritis and peptic ulcer disease. the etiologies of many infectious diseases have been attributed to specific or clonal strains of bacterial pathogens. polymerase chain reaction (pcr) amplification of dna between repetitive dna sequences, rep elements (rep-pcr), has been utilized to generate dna fingerprints to examine similarity among strains within a bacterial species.	1995	7481525
is helicobacter pylori infection a real risk factor for gastric carcinoma?	that helicobacter pylori has a role in the pathogenesis of gastric carcinoma is widely accepted, although not all doubts are definitively clarified. the purpose of this work was to detect the differences in presence and mean titer of anti-h. pylori antibodies between groups with gastric (n = 65), colonic (n = 70), and lung (n = 43) carcinoma.	1995	7481526
gastric output of iga in man: relation to migrating motility complexes and sham feeding.	the immunologic reactivity of the gastric mucosa is poorly understood. the origin and dynamics of immunoglobulin a (iga) occurring in the gastric lumen were investigated in healthy, helicobacter pylori-negative volunteers.	1995	7481528
dyspeptic symptoms and gastric emptying of solids in patients with functional dyspepsia. role of helicobacter pylori infection.	our aim was to investigate the relation between dyspeptic symptoms, gastric emptying of digestible and indigestible solids, and helicobacter pylori infection in patients with functional dyspepsia.	1995	7481541
helicobacter pylori seropositivity among swedish adults with and without abdominal symptoms. a population-based epidemiologic study.	the role of helicobacter pylori in functional dyspepsia is unclear. the aim of this population-based study was to determine whether the prevalence of h. pylori infection is higher among people with dyspepsia or irritable bowel syndrome (ibs) than among symptomless persons after control for age, sex, and socioeconomic status.	1995	7481542
serum values of pepsinogens and antibodies to helicobacter pylori in relation to a history of peptic ulcer disease and nsaid use.	the present study was undertaken to investigate whether patients with a history of peptic ulcer disease (pud) have serological features indicative of the presence of more severe gastritis, compared to patients without a history of pud. in addition we investigated whether current chronic use of non steroidal anti-inflammatory drugs (nsaids) was associated with serological features indicative of a chemical (type c) gastritis. in total 850 consecutive outclinic patients were interviewed by a standa ...	1995	7481582
helicobacter pylori positivity in asymptomatic children of different ethnic groups living in the same country.		1995	7482096
helicobacter pylori-associated gastritis: does it play a role in functional dyspepsia?	the goal of this study is to averiguate whether helicobacter pylori (hp)-associated gastritis is involved in the etiology of functional dyspepsia (fd) or, at least in a subset of these patients.	1995	7483732
[helicobacter pylori, nonsteroidal anti-inflammatory agents and gastroduodenal changes].	the author discusses the possible interactions between non-steroidal anti-inflammatory drugs (nsaids) and helicobacter pylori (hp) which may play an important role in the unleashing of gastroduodenal lesions. to our knowledge, aines have no influence on the prevalence of infection by hp and the latter does not seem to influence the development and intensity of the lesions caused by nsaids.	1995	7484272
helicobacter pylori and gastrointestinal disease.	helicobacter pylori infection is quite common. in the united states, prevalence varies considerably with race, nationality, socio-economic status and location of residence. in western countries, the prevalence of the infection has shown a steady increase with increasing age. h. pylori has been shown to cause chronic gastritis. most patients infected with h. pylori are asymptomatic and require no therapy. the precise role of the infection in the pathogenesis of peptic ulcer disease is unknown. ho ...	1995	7484682
confirmation of successful therapy of helicobacter pylori infection: number and site of biopsies or a rapid urease test.	although a number of tests have been described to detect the presence of helicobacter pylori in biopsy specimens, studies of positive and negative value have largely been performed on untreated patients; testing the reliability of posttherapy has not been done.	1995	7485000
evaluation of a new urease reagent strip for detection of helicobacter pylori in gastric biopsy specimens.	determine sensitivity and specificity of a new urease reagent strip (urs) test for detection of helicobacter pylori in gastric biopsy specimens.	1995	7485001
prevalence of helicobacter pylori infection in patients with large gastric folds: evaluation and follow-up with endoscopic ultrasound before and after antimicrobial therapy.	large gastric folds may result from infectious, inflammatory, neoplastic, vascular, and infiltrative disorders involving a part or the entire gastric wall. helicobacter pylori infection of the gastric mucosa is associated with an active gastritis characterized by infiltration of the mucosa and submucosa with neutrophils, eosinophils, macrophages, and lymphocytes. the purposes of the study were: 1) to study patients with large gastric folds noted on computed tomography, upper gastrointestinal ser ...	1995	7485002
re: [13c]urea breath test.		1995	7485036
helicobacter pylori: the first description.		1995	7485037
partial characterization and effect of omeprazole on atpase activity in helicobacter pylori by using permeabilized cells.	atpase activity in permeabilized cells of helicobacter pylori as well as those of helicobacter felis and campylobacter jejuni was analyzed. the atpase activities in these cells were most susceptible to sodium azide, fluoroaluminate, and dicyclohexylcarbodiimide, which are typical inhibitors of f atpases. optimal values for maximal activity were found to be at approximately ph 6.4, 6.0, and 6.0 for c. jejuni, h. pylori, and h. felis, respectively. the substituted benzimidazole compounds omeprazol ...	1995	7486907
bactericidal and morphological effects of amoxicillin on helicobacter pylori.	the growth kinetics of helicobacter pylori after it has been exposed to amoxicillin have been investigated in conjunction with studies of cell morphology. a potent bactericidal effect was observed at concentrations 10-fold higher than the mic, but this was accompanied by an increase in the residual numbers of coccoid forms observed. in the presence of 10 micrograms of amoxicillin per ml, these forms could be detected as rapidly as 6 h after exposure to the antibiotic. although the clinical relev ...	1995	7486933
nonulcer dyspepsia and helicobacter pylori: causal or coincidental?		1995	7487249
cyclodextrins for growth of helicobacter pylori and production of vacuolating cytotoxin.	growth of helicobacter pylori in liquid culture requires the addition of media supplements that often interfere with subsequent purification of bacterial antigens. in order to determine whether cyclodextrins can substitute for conventional h. pylori growth supplements, we cultured h. pylori in the presence of five commercially available cyclodextrins. the effect of these compounds on the production of the vacuolating cytotoxin antigen was evaluated. several cyclodextrins supported flourishing gr ...	1995	7487335
prospective study of helicobacter pylori infection in primary gastric lymphoma.		1995	7489168
[helicobacter pylori infections: familial clustering and transmission].	the importance of helicobacter pylori for the development of gastritis and gastro-duodenal ulceration is generally accepted. the objective of the presented work was to find out whether its transmission is involved in families of children examined on account of upper dyspeptic syndrome. aggregation and transmission of helicobacter pylori infection were not described so far in the czech republic.	1995	7489580
genetic organization of a small cryptic plasmid of helicobacter pylori.	a 2.9-kb cryptic plasmid of helicobacter pylori (hp), phel1, was isolated and the complete nucleotide (nt) sequence was determined. an open reading frame (orf1) was identified encoding a putative polypeptide of 63,709 da, the existence and correct size of which was confirmed by t7 promoter expression analysis. the orf1 sequence showed strong amino-acid sequence identity to a recently identified putative orf1 protein of a cryptic hp plasmid, phpm180, and significant homologies to putative rep pro ...	1995	7489910
lymphocytic gastritis and helicobacter pylori infection in gastric lymphoma.	lymphocytic gastritis and primary gastric lymphoma are rare conditions with unknown aetiology. it has recently been suggested that helicobacter pylori has a role in the pathogenesis of both of them. the occurrence of lymphocytic gastritis and h pylori was studied in a series of patients with primary gastric lymphoma. the cases of primary gastric lymphomas (n = 35) diagnosed in years 1970-1993 were identified. the specimens of 22 cases contained gastric mucosa sufficiently so that the number of i ...	1995	7489930
omeprazole enhances efficacy of triple therapy in eradicating helicobacter pylori.	triple therapy has been recommended as the most effective treatment for helicobacter pylori eradication. despite achieving a comparatively high eradication result, however, around 10% of patients still fail to be cured. omeprazole can enhance efficacy of single and double antibiotic protocols and is particularly effective when combined with clarithromycin and a nitroimidazole. this study examined the effect of combining triple therapy with omeprazole. a prospective, randomised, unblinded, single ...	1995	7489931
eradication of helicobacter pylori restores the inhibitory effect of cholecystokinin on postprandial gastrin release in duodenal ulcer patients.	helicobacter pylori infection may be associated with duodenal ulcer (du) and accompanied by enhanced gastrin release but the mechanism of this h pylori related hypergastrinaemia in du patients is unclear. cholecystokinin (cck) has been implicated in the feedback control of gastrin release and gastric acid secretion in healthy subjects. this study therefore investigated if cck participates in the impairment of postprandial gastrin release and gastric secretion in six du patients. tests were under ...	1995	7489932
gastric mucus viscosity and helicobacter pylori.		1995	7489954
eradication rate of helicobacter pylori.		1995	7489956
eradication rate of helicobcter pylori.		1995	7489957
organic and psychosocial risk factors for duodenal ulcer.	duodenal ulcer (du) is a common medical disorder which frequently becomes chronic. the factors involved in the aetiology of du are poorly understood. evidence for the contribution of psychosocial factors to the onset of du is reviewed in the context of evidence of organic factors, genetic and environmental, with special reference to new evidence of infectious agents in the aetiology of du. recent progress in understanding of biological forces of duodenal ulcer disease has lead to a substantially ...	1995	7490691
laboratory-acquired helicobacter pylori infection.		1995	7491010
nodular gastritis associated with helicobacter helmannii infection.		1995	7491030
[helicobacter pylori status--how, when and in whom?].		1995	7491724
influence of blood group and secretor status on carbohydrate structures in human gastric mucins: implications for peptic ulcer.	1. the content and distribution of carbohydrate was examined in mucus glycopolypeptides from human antral mucosae. 2. the mean amount of carbohydrate per 1000 amino acid residues was found to be similar in glycopolypeptides with a, b or h activity. it was slightly, though significantly, less in glycopolypeptides lacking these determinants, because carbohydrate chains were of a shorter average length than in the a-, b- or h-active preparations. this difference was reflected in the sizes of oligos ...	1995	7493441
gastric cancer among the japanese in hawaii.	the incidence rate of gastric cancer among men of japanese ancestry living in hawaii is about one-third as high as that of their counterparts living in japan. because of this difference, a prospective study was conducted to identify factors related to the development of gastric cancer in hawaii. eight thousand and six (8,006) men born from 1900-1919 were examined from 1965 to 1968 and followed for over 25 years. during this time, 250 incident cases of gastric cancer were identified. the study ha ...	1995	7493909
characterization of feline helicobacter pylori strains and associated gastritis in a colony of domestic cats.	twenty-four young adult domestic cats from a commercial vendor were found to be infected with helicobacter pylori. histopathologic analyses, selected electron microscopy, and urease mapping were performed on mucosal samples collected from the cardias and fundi, bodies, and antra of these cats' stomachs. h. pylori organisms were abundant in all areas of the stomach on the basis of histologic evaluation and urease mapping. h. pylori infection was associated with a moderate to severe lymphofollicul ...	1995	7494015
characterization of chromosomal dna profiles from helicobacter pylori strains isolated from sequential gastric biopsy specimens.	the restriction endonuclease profiles of dnas from helicobacter pylori strains isolated from 20 patients in two or more consecutive biopsy specimens over a period of up to 2 years were analyzed by pulsed-field gel electrophoresis with noti and nrui. h. pylori strains possess a high degree of genomic diversity which was not observed to occur in vivo, and attempts to observe it in vitro were not successful.	1995	7494058
helicobacter pylori and radical therapy for peptic ulcer.		1995	7494763
evaluation of the "one-minute" test for detecting helicobacter (campylobacter) pylori infection.	the "one-minute" urease test to detect helicobacter (campylobacter) pylori infection was evaluated using histology and culture as the "gold standard". the test was performed in a blinded manner and compared with the conventional christensen's urease test. helicobacter pylori was detected in 88 of 100 consecutive patients attending the gastrointestinal clinic for upper endoscopy. although the "one-minute" urease test was more sensitive [86% (76/88)] than the conventional christensen's urease test ...	1995	7495205
influence of helicobacter pylori colonization on histological grading of chronic gastritis in korean patients with peptic ulcer.	we conducted an analysis of correlation between histological grading of chronic gastritis and the presence of h. pylori infection to investigate if h. pylori influences histological severity of chronic gastritis in korean patients with peptic ulcers.	1995	7495770
the role of helicobacter pylori in gastritis and its progression to peptic ulcer disease.	helicobacter pylori infection is now recognized as the major cause of chronic gastritis throughout the world. a fraction of infected persons develop peptic ulcer disease or gastric cancer, accounting for its clinical significance. the pathophysiology of this infection can be better understood by considering five central concepts--heterogeneity of strains, persistence of infection, immunological down-regulation, physiological consequences and variability in outcome. microbial, host and environmen ...	1995	7495938
unanswered questions about helicobacter pylori.	there is general agreement that helicobacter pylori eradication is indicated in all infected patients with duodenal ulcer disease and is probably indicated in all infected patients with gastric ulcer disease. however, translation of treatment recommendations into practice leads to some difficult clinical decisions. three of the more perplexing questions are whether or not all patients with dyspepsia and h. pylori should be treated, whether or not a definitive diagnosis of ulcer should be establi ...	1995	7495940
no helicobacter pylori, no helicobacter pylori-associated peptic ulcer disease.	virtually all duodenal ulcers (dus) and the vast majority of gastric ulcers (gus) are the consequence of helicobacter pylori-associated inflammation. in dus, the inflammation is maximal in the antrum and is associated with gastric metaplasia in the bulb. gastrin homeostasis is disturbed by h. pylori gastritis and there is robust acid secretion. successful eradication of the infection cures the ulcer diathesis. amalgamated figures for ulcer relapse per year in h. pylori-positive dus are > 60% com ...	1995	7495941
the role of acid in upper gastrointestinal haemorrhage due to ulcer and stress-related mucosal damage.	a peptic ulcer is a lesion in which acid and pepsin are essential components of pathogenesis. regardless of the type of patient or the setting in which the ulcer presents, the basic pathogenetic scheme is the same. the primary event is disruption of mucosal integrity. in the presence of acid and pepsin, such disruption of integrity leads to an ulcer. while rarely sufficient by itself to cause ulceration, the presence of acid is a necessary cofactor. the causes of disruption of mucosal integrity ...	1995	7495942