Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| involvement of pgc-1, nrf-1, and nrf-2 in metabolic response by rat liver to hormonal and environmental signals. | we studied liver oxidative capacity and o2 consumption in hypothyroid rats treated for 10 days with t4, or t3, or treated for 10 days with t3 and exposed to cold for the last 2 days. the metabolic response of homogenates and mitochondria indicated that all treatments increased the synthesis of respiratory chain components, whereas only the cold-induced mitochondrial proliferation. determination of mrna and protein expression of transcription factor activators, such as nrf-1 and nrf-2, and coacti ... | 2009 | 19433258 |
| carbohydrate analysis of acanthamoeba castellanii. | we analyzed biochemically acanthamoeba castellanii trophozoites, intact cysts and cyst walls belonging to the t4 genotype using gas chromatography combined with mass spectrometry. cyst walls were prepared by removing intracellular material from cysts by pre-treating them with sodium dodecyl sulphate (sds) containing dithiothreitol, and then subjecting these to a series of sequential enzymatic digestions using amyloglucosidase, papain, dnase, rnase and proteinase k. the resulting "cyst wall" mate ... | 2009 | 19389397 |
| caspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: implications for the pathogenesis of alzheimer disease. | in alzheimer disease (ad) mitochondrial abnormalities occur early in the pathogenic process and likely play a significant role in disease progression. tau is a microtubule-associated protein that is abnormally processed in ad, and a connection between tau pathology and mitochondrial impairment has been proposed. however, few studies have examined the relationship between pathological forms of tau and mitochondrial dysfunction. we recently demonstrated that inducible expression of tau truncated a ... | 2009 | 19389700 |
| phenotypic and functional characterization of human mammary stem/progenitor cells in long term culture. | cancer stem cells exhibit close resemblance to normal stem cells in phenotype as well as function. hence, studying normal stem cell behavior is important in understanding cancer pathogenesis. it has recently been shown that human breast stem cells can be enriched in suspension cultures as mammospheres. however, little is known about the behavior of these cells in long-term cultures. since extensive self-renewal potential is the hallmark of stem cells, we undertook a detailed phenotypic and funct ... | 2009 | 19390630 |
| compensatory sweating after thoracoscopic sympathectomy: characteristics, prevalence and influence on patient satisfaction. | this prospective study aimed at investigating predictive factors for compensatory sweating after thoracoscopic sympathectomy. | 2009 | 19390718 |
| selenium and thyroid hormone axis in critical ill states: an overview of conflicting view points. | in critical ill states the plasma selenium levels are low and inversely correlated with the severity and outcome of the disease. the plasma selenium levels indicate the amount of circulating selenoproteins and selenoenzymes. these are important for the maintenance of the redox system, modulating the immune system and also for thyroid hormone metabolism. not only all three deiodinases (d1-3) are selenoenzymes, but within the thyroid gland there are several other selenoenzymes, which are important ... | 2009 | 19398053 |
| surgical management of superficial siderosis. | superficial siderosis is a rare condition resulting from the presence of chronic bleeding into the subarachnoid space usually causing gait instability and deafness. the surgical management of superficial siderosis depends on localizing the source of hemorrhage. | 2009 | 19398385 |
| pleural malignant mesothelioma causing cord infiltration through the nerve root. case report. | a 61-year-old man presented with a rare pleural malignant mesothelioma of the spine manifesting as progressive weakness of the bilateral lower extremities, numbness in the body and both legs, and dysfunction of the bladder and bowel. he had previous occupational exposure to asbestos while working at a car repair shop and had undergone right panpleuropneumonectomy under a diagnosis of sarcomatous type mesothelioma in the right pleural space. magnetic resonance imaging of the spine with gadolinium ... | 2009 | 19398862 |
| quantitative thyroid scintigraphy in greyhounds suspected of primary hypothyroidism. | the existence of hypothyroidism in greyhounds remains controversial and its investigation is complicated by the low circulating thyroid hormone concentrations typically found in healthy dogs of this breed. quantitative measurement of thyroidal technetium-99m pertechnetate ((99m)tco4-) uptake is known to be useful in assessing thyroid function in other breeds. the aim of this study was to evaluate thyroid scintigraphy as a method of assessing thyroid function in greyhounds suspected of primary hy ... | 2009 | 19400473 |
| the prevalence of thyroid dysfunction in an iodine-sufficient area in iran. | the prevalence of hypothyroidism in iran is unknown. the aims of the present study were to estimate the prevalence of overt and subclinical hypothyroidism among the adult population of isfahan, a large metropolitan city in iran, 15 years after universal salt iodization. | 2009 | 19400604 |
| comparison of the effect of propofol and n-acetyl cysteine in preventing ischaemia-reperfusion injury. | the aim of this study was to compare the effects of propofol and n-acetyl cysteine (nac) on tourniquet-induced ischaemia-reperfusion injury by determining malonyldialdehyde, ischaemia-modified albumin, lactate, blood gas and haemodynamic levels in arthroscopic knee surgery. | 2009 | 19401659 |
| effects of selenomethionine supplementation on selenium status and thyroid hormone concentrations in healthy adults. | selenium, a potential cancer prevention agent currently being tested against prostate cancer in the selenium and vitamin e cancer prevention trial (select), plays an integral role in thyroid metabolism. the effects of long-term selenium supplementation on thyroid hormone concentrations are unknown. | 2009 | 19403637 |
| resistance of acanthamoeba cysts to disinfection in multiple contact lens solutions. | acanthamoebae are free-living amoebae found in the environment, including soil, freshwater, brackish water, seawater, hot tubs, and jacuzzis. acanthamoeba species can cause keratitis, a painful vision-threatening infection of the cornea, and fatal granulomatous encephalitis in humans. more than 20 species of acanthamoeba belonging to morphological groups i, ii, and iii distributed in 15 genotypes have been described. among these, acanthamoeba castellanii, a. polyphaga, and a. hatchetti are frequ ... | 2009 | 19403771 |
| acute chest pain in a top soccer player due to thoracic disc herniation. | case report. | 2009 | 19404165 |
| management of squamous cell carcinoma of the base of tongue with chemoradiation and brachytherapy. | treatment of base of tongue (bot) squamous cell carcinoma (scc) has traditionally been associated with poor prognosis and significant morbidity. we report a program consisting of concurrent chemoradiation followed by brachytherapy for these patients. | 2009 | 19405086 |
| adjustment of n stages of gastric cancer by the ratio between the metastatic and examined lymph nodes. | the present study attempted to determine whether n stage could be adjusted for the differences in survival rates based on the ratio between the examined and metastatic lymph nodes (ln ratio). | 2009 | 19434459 |
| [expression of galectin 3 and sambucus nigra agglutinin and their clinicopathological significance in benign and malignant lesions of stomach]. | to study the expressive levels of galectin-3(gal-3) and sambucus nigra agglutinin(sna) and their clinicopathological significance in the benign and malignant lesions of stomach. | 2009 | 19434543 |
| photo-assisted gene delivery using light-responsive catanionic vesicles. | photoresponsive catanionic vesicles have been developed as a novel gene delivery vector combining enhanced cellular uptake with phototriggered release of vesicle payload following entry into cells. vesicles with diameters ranging from 50 to 200 nm [measured using cryo-transmission electron microscopy (tem) and light-scattering techniques] form spontaneously, following mixing of positively charged azobenzene-containing surfactant and negatively charged alkyl surfactant species. fluorescent probe ... | 2009 | 19435291 |
| what is the role for surgery in patients with stage iii non-small cell lung cancer? | locally advanced non-small cell lung cancer (nsclc) represents a therapeutic challenge. although combined modality has become the standard treatment in stage iii nsclc, the role of surgery in it remains controversial. this review will address recent evidence on the potential role of surgery in either superior sulcus tumors, t4n0-1 tumors with central extension multifocal tumors with nodule(s) in the same lobe, or stage iii disease with mediastinal lymph node involvement. | 2009 | 19465855 |
| plant growth-promoting rhizobacteria allow reduced application rates of chemical fertilizers. | the search for microorganisms that improve soil fertility and enhance plant nutrition has continued to attract attention due to the increasing cost of fertilizers and some of their negative environmental impacts. the objectives of this greenhouse study with tomato were to determine (1) if reduced rates of inorganic fertilizer coupled with microbial inoculants will produce plant growth, yield, and nutrient uptake levels equivalent to those with full rates of the fertilizer and (2) the minimum lev ... | 2009 | 19466478 |
| association between tumor necrosis factor alpha 308g/a polymorphism and increased proinflammatory cytokine release after cardiac surgery with cardiopulmonary bypass in the korean population. | the g-308a polymorphism of the tumor necrosis factor alpha (tnf-alpha) gene has been suggested to be linked to high tnf promoter activity in in vitro studies. however, there have been some controversies in in vivo studies. this study investigated whether a allele at tnf-308 site is associated with (1) the changes in plasma cytokine levels during and after cardiopulmonary bypass (cpb) and (2) an increased incidence of pulmonary morbidity after cpb. | 2009 | 19467887 |
| sentinel node biopsy for the individualization of surgical strategy for cure of early-stage colon cancer. | the requirement for nodal analysis currently confounds the oncological propriety of focused purely endoscopic resection for early-stage colon cancer and complicates the evolution of innovative alternatives such as natural orifice transluminal endoscopic surgery (notes) and its hybrids. adjunctive sentinel node biopsy (snb) deserves consideration as a means of addressing this shortfall. | 2009 | 19472012 |
| systolic pulmonary artery pressure and echocardiographic measurements in patients with euthyroid hashimoto's thyroiditis. | the aim of this study was to investigate systolic pulmonary artery pressure (spap) and echocardiographic findings in patients with euthyroid hashimoto's thyroiditis (ht). | 2009 | 19474524 |
| metastasis to the sigmoid or sigmoid mesenteric lymph nodes from rectal cancer. | we analyzed metastases to the sigmoid and sigmoid mesenteric lymph nodes from rectal cancer. | 2009 | 19474698 |
| evaluation of new thiadiazoles and benzothiazoles as potential radioprotectors: free radical scavenging activity in vitro and theoretical studies (qsar, dft). | thiol and aminothiol compounds are among the most efficient chemical radioprotectors. to increase their efficiency, we synthesized two new classes of thiol and aminothiol compounds derived from benzothiazole (t1, t2, am1, am2) and thiadiazole (t3, t4, am3) structures. we examined them for their ability to scavenge free radicals (dpph*, abts(*+), *oh). thiol derivatives with a thiadiazole structure are the most active compounds scavenging dpph* and abts(*+) free radicals, with an ic(50) of 0.053+ ... | 2009 | 19439222 |
| enantioselective determination of thyroxine enantiomers by ligand-exchange ce with uv absorbance and icp-ms detection. | a simple ce method has been developed for the separation and determination of thyroxine (t4) enantiomers in pharmaceutical formulations. the method was based on ligand-exchange mechanism using a cu(ii)/l-proline complex as chiral selector. the effects of different parameters affecting separation such as chiral selector concentration, organic additive, buffer ph and temperature were investigated. a baseline separation of the two enantiomers was obtained at a cu(ii)/l-proline ratio of 1:8 in a bor ... | 2009 | 19441034 |
| cyp1a2*1c, cyp2e1*5b, and gstm1 polymorphisms are predictors of risk and poor outcome in head and neck squamous cell carcinoma patients. | head and neck squamous cell carcinoma (hnscc) is associated with environmental factors, especially tobacco and alcohol consumption. most of the carcinogens present in tobacco smoke are converted into dna-reactive metabolites by cytochrome p450 (cyps) enzymes and detoxification of these substances is performed by glutathione s-transferases (gsts). it has been suggested that genetic alterations, such as polymorphisms, play an important role in tumorigenesis and hnscc progression. the aim of this s ... | 2009 | 19442564 |
| clinical and pathological response to primary chemotherapy in patients with locally advanced breast cancer grouped according to hormonal receptors, her2 status, grading and ki-67 proliferation index. | biological markers that reliably predict clinical and pathological response to primary systemic therapy may have considerable clinical potential; this study evaluated response compared to expression of er, pgr and her2, grading and ki-67 proliferation index before and after neoadjuvant chemotherapy in patients with locally advanced breast cancer (labc). | 2009 | 19443376 |
| structural basis for the nuclease activity of a bacteriophage large terminase. | the dna-packaging motor in tailed bacteriophages requires nuclease activity to ensure that the genome is packaged correctly. this nuclease activity is tightly regulated as the enzyme is inactive for the duration of dna translocation. here, we report the x-ray structure of the large terminase nuclease domain from bacteriophage spp1. similarity with the rnase h family endonucleases allowed interactions with the dna to be predicted. a structure-based alignment with the distantly related t4 gp17 ter ... | 2009 | 19444313 |
| the effect of treatment on survival in patients with advanced laryngeal carcinoma. | over the last 2 decades, survival from laryngeal cancer has decreased. we sought to identify factors associated with decreased survival in laryngeal cancer. | 2009 | 19444887 |
| [ct evaluation of locoregional spread of carcinoma of the gallbladder]. | this study aims to assess the diagnostic capability of ct to preoperatively detect evidence of locoregional spread of gallbladder cancer. | 2009 | 19446691 |
| preparation of long sticky ends for universal ligation-independent cloning: sequential t4 dna polymerase treatments. | ligation-independent cloning (lic) is a useful method for efficient directional cloning of a pcr product. lic requires a specially designed vector containing a long stretch of sequence that is missing any one of the four nucleotides. when the linearized vector is treated with t4 dna polymerase, in the presence of the absent base, long single-stranded overhangs are generated that are suitable for cloning. in this study, long and efficient sticky ends for lic were produced by sequential t4 dna pol ... | 2009 | 19447347 |
| accuracy of sentinel node biopsy in breast cancer patients with a high prevalence of axillary metastases. | sentinel lymph node biopsy (slnb) has become a standard diagnostic tool for axillary staging of breast cancer and has many advantages in comparison with axillary dissection. the goal of our study was to determine accuracy and predictive value of slnb for assessing the axillary lymph nodes involvement in breast cancer. | 2009 | 19447739 |
| thyroid function in the critically ill newborn and child. | here we review typical thyroid function alterations observed in the critically ill pediatric patient. | 2009 | 19448543 |
| turner's syndrome and subclinical autoimmune thyroid disease: a two-year follow-up study. | although autoimmune thyroid disease (aitd) is frequent in turner's syndrome (ts), followup studies are scant, and there are none regarding subclinical thyroiditis. we investigated thyroid function and morphology in 17 patients with ts (mean age 14.6 years) with transient and asymptomatic variations of tsh and/or thyroid hormones. our 2-year follow-up included measurements of tsh, free t4, t3 and tpo and tg antibodies, ultrasound (us) (first and last evaluations) and scintigraphy (first evaluatio ... | 2009 | 19449668 |
| treatment results and late complications of 556 patients with locally advanced nasopharyngeal carcinoma treated with radiotherapy alone. | the aim of this study was to investigate the outcome in 556 patients with locally advanced nasopharyngeal carcinomas treated by radiation therapy alone. we observed 556 patients with stage t3-4 and n0-3 carcinoma who were treated by conventional radiotherapy alone between january and december 1999. the total dose delivered to the nasopharynx was 66-80 gy over 6.5-8 weeks and to the neck lymph nodes 60-70 gy over 6-7 weeks. the 5-year actuarial overall survival rate (os) reached 66.41%. the os wa ... | 2009 | 19451314 |
| effect of treadmill training on autonomic dysreflexia in spinal cord--injured rats. | weight-supported treadmill training is an emerging rehabilitation method used to improve locomotor ability in patients with spinal cord injury (sci). however, little research has been undertaken to test the effect of such training on other consequences of sci, such as neuropathic pain and autonomic dysfunction. | 2009 | 19451618 |
| squamous cell carcinoma of the urinary bladder: a clinicopathologic and immunohistochemical study of 16 cases. | squamous cell carcinoma is an uncommon histologic type in the urinary bladder. we searched our surgical pathology files and identified 16 cases of squamous cell carcinoma of the urinary bladder. the mean age of patients was 65.4 years (range, 41-77 years). all patients received transurethral resection of the bladder, which demonstrated pure squamous cell carcinomas. seven patients had clinical evidence of tumor spreading out of the bladder (t4) and did not undergo radical cystectomy. the other 9 ... | 2009 | 19454359 |
| safety and efficacy of sugammadex for the reversal of rocuronium-induced neuromuscular blockade in cardiac patients undergoing noncardiac surgery. | the present randomized, safety-assessor blinded, placebo-controlled trial was designed to assess safety and efficacy of sugammadex, a novel selective relaxant-binding agent, in patients with underlying cardiovascular disease undergoing noncardiac surgery. | 2009 | 19455040 |
| assessment of urinary iodine excretion among normal kuwaiti adults. | this study was performed to investigate the status of iodine intake among the kuwaiti population and its effect on thyroid function. the study group was comprised of 139 females and 86 males with a mean age of 33 and 35 years, respectively. urinary iodine excretion (uie) and serum free t4 (ft4), thyrotropin hormone (tsh), antiperoxidase antibodies (anti- tpoab), and antithyroglobulin antibodies (anti-tgab) were determined. median uie was 148 μg/l (within the recommended level by the world health ... | 2009 | 19455284 |
| thyroid status can influence brain mast cell population. | neuroanatomical mapping as well as the influence of thyroid status on brain mast cell distribution and detectable mast cell number in adult rana esculenta is studied. treatment with tizoxin (t4) does not modify number or activational state of brain mast cells, whereas administration of the antithyroid agent 6-n-propyl-2-thiouracil induces a significant increase (up to 40%) in the mast cell number within the telencephalon and diencephalon. hypophysectomy induces a significant decrease (up to 65%) ... | 2009 | 19456362 |
| anti-thyroid hormone activity of bisphenol a, tetrabromobisphenol a and tetrachlorobisphenol a in an improved reporter gene assay. | previously, we transiently transfected gal4-fused thyroid hormone receptor (tr) expressing vector and the gal4 response reporter structure puas-tk-luc into hepg2 cell, developed a tr beta-1 mediated reporter gene assay to screen for compounds that acted on the tr signaling pathway. in this study, we improved the test efficiency by changing the transfected cell line into cv-1 cell. triiodothyronine (t3) and thyroxine (t4) induced higher luciferase expression, with the median effective concentrati ... | 2009 | 19457453 |
| glycogenic induction of thyroid hormone conversion and leptin system activation in the liver of postpartum dairy cows. | in the regulation of energy metabolism, the liver plays an important role in the reinforcement of energy production. in periparturient cows the energy homeostasis turns into a negative energy balance that may shift the physiological regulation of energy balance towards pathological processes. propylene glycol (pg), as a complementary source of energy used in the nutrition of dairy cows, alters systemic thyroid hormone economy; however, the exact mechanism through which highly glycogenic feed sup ... | 2009 | 19457782 |
| [rapid site-directed mutagenesis on full-length plasmid dna by using designed restriction enzyme assisted mutagenesis]. | to use the designed restriction enzyme assisted mutagenesis technique to perform rapid site-directed mutagenesis on double-stranded plasmid dna. the target amino acid sequence was reversely translated into dna sequences with degenerate codons, resulting in large amount of silently mutated sequences containing various restriction endonucleases (res). certain mutated sequence with an appropriate re was selected as the target dna sequence for designing mutation primers. the full-length plasmid dna ... | 2009 | 19459340 |
| changes in the content of major proteins and selected hormones in the blood serum of piglets during the early postnatal period. | the aim of the study was to determine the changes in the content of major proteins, glucose and selected hormones in the blood of piglets during the first 7 days of neonatal life. the study involved an entire litter of eight newborn piglets of f1 hybrids (polish white large x polish landrace) delivered from one sow in the second gestation. in blood samples collected directly after parturition (before colostrum intake), in the 12th, 24th and 48th hour and in 7th day of life, the content of total ... | 2009 | 19459467 |
| [immunodiagnostic value and immune protection of the recombinant ts21 antigen of trichinella spiralis]. | to study the immunodiagnostic value and immune protection of the recombinant ts21 protein of trichinella spiralis. | 2009 | 19459493 |
| neuroendocrine function following traumatic brain injury and subsequent intensive care treatment: a prospective longitudinal evaluation. | neuroendocrine dysfunction following traumatic brain injury (tbi) has been described extensively. however, few studies are longitudinal and most lack subtle radiological, clinical, and repetitive endocrine assessment in the acute phase. accordingly, we prospectively assessed neuroendocrine function in 71 patients after tbi. injury was documented by a computed tomography (ct). during the first week, critical clinical data (glasgow coma score, apache score), treatment variables such as duration of ... | 2009 | 19459759 |
| [an operative case of ulcerative colitis associated with hyperthyroidism]. | we encountered a rare operative case of hyperthyroidism followed by ulcerative colitis (uc). a 26-year-old mam was referred to our department to undergo an operation. we suspected the possible complication of adrenal insufficiency, since he suffered from severe weight loss, a high fever and palpitation on admission. we diagnosed hyperthyroidism, however, based on the presence of high serum free t3 and t4 levels and a decreased tsh level. after improving the symptoms and the thyroid function by a ... | 2009 | 19498314 |
| visfatin plasma concentrations in patients with hyperthyroidism and hypothyroidism before and after control of thyroid function. | alterations in thyroid function are associated with changes in body weight, metabolism, and low-grade inflammation. in several studies, plasma levels of visfatin were found to be associated with body mass index, diabetes, and metabolic syndrome. in our study we aimed to evaluate visfatin levels according to thyroid dysfunction. the study cohort comprised 56 hashimoto thyroiditis patients with hypothyroidism (43.94+/-14.27 yr), 56 graves patients with hyperthyroidism (45.87+/-13.28 yr), and 56 eu ... | 2009 | 19498324 |
| renal cell carcinoma. 2002 tnm classification is still adequate? | the tnm classification should be a tool that allows the physician to make therapeutic decisions and gain even a prognostic scheme. currently, the 2002 tnm classification for kidney cancer doesn't have these features. really it doesn't make a distinction when performed a conservative therapy in the early stages: literature and the clinical experience suggest that the criteria for a partial resection of the kidney is the location of the tumour, rather than its size; for this reason, the division p ... | 2009 | 19499760 |
| controlling the morphology in dna condensation and precipitation. | this work addresses the influence of solution inhomogeneity on conformation, aggregation, and coil/globule and bundle/single chain coexistence of t4 dna molecules. the inhomogeneity is induced by mixing two solutions containing, respectively, protamine and dna, with different relative concentrations, but aiming at producing the same final concentrations. the study was conducted by means of fluorescence microscopy (fm), complemented with scanning electron microscopy (sem). it is shown that the de ... | 2009 | 19499951 |
| outbreak of betanodavirus infection in tilapia, oreochromis niloticus (l.), in fresh water. | a betanodavirus associated with a massive mortality was isolated from larvae of tilapia, oreochromis niloticus, maintained in fresh water at 30 degrees c. histopathology revealed vacuolation of the nervous system, suggesting an infection by a betanodavirus. the virus was identified by indirect fluorescent antibody test in the ssn1 cell line and further characterized by sequencing of a pcr product. sequencing of the t4 region of the coat protein gene indicated a phylogenetic clustering of this is ... | 2009 | 19500206 |
| tsh-lowering effect of metformin in type 2 diabetic patients: differences between euthyroid, untreated hypothyroid, and euthyroid on l-t4 therapy patients. | to assess the interplay between metformin treatment and thyroid function in type 2 diabetic patients. | 2009 | 19502536 |
| construction of an energy transfer system in the bio-nanocup space by heteromeric assembly of gp27 and gp5 proteins isolated from bacteriophage t4. | protein assemblies, such as viruses and ferritins, have been employed as useful molecular templates for the accumulation of organic and inorganic compounds to construct bio-nanomaterials. while several methods for conjugation of heterofunctional molecules with protein assemblies have been reported, it remains difficult to control their fixation sites in the assemblies. in this article, we demonstrate the three-dimensional arrangement of different types of fluorescent probes using the heteromeric ... | 2009 | 19503942 |
| micropapillary component in colorectal carcinoma is associated with lymph node metastasis in t1 and t2 stages and decreased survival time in tnm stages i and ii. | colorectal carcinoma with a micropapillary component (mp) is an exceptionally aggressive variant, but has never been investigated in terms of survival analysis. thirty colorectal carcinomas with a mp were identified from a series of 221 colorectal carcinomas. carcinomas with and without a mp were compared in terms of histologic and immunohistochemical markers. colorectal carcinoma with a mp seemed to have a lower differentiation status, increased tumor budding, more frequent lymphovascular and p ... | 2009 | 19471152 |
| immunoprotective analysis of vhhp2, a vibrio harveyi vaccine candidate. | vhhp2 is an outer membrane protein identified in a pathogenic vibrio harveyi strain, t4, isolated from diseased fish. when used as a subunit vaccine, purified recombinant vhhp2 affords high level of protection upon japanese flounder against v. harveyi challenge. vaccination with vhhp2 induced the expression of a number of immune-related genes, especially those encoding immunoglobulin m (igm) and major histocompatibility complex (mhc) iialpha. a vhhp2 surface display system, in the form of the fi ... | 2009 | 19428886 |
| hsp90b1, a thyroid hormone-responsive heat shock protein gene involved in photoperiodic signaling. | in order to further advance the understanding of genes involved in avian photoperiodic signaling, a chicken hypothalamic cdna microarray was made to identify changes in gene expression in the whole hypothalamus of juvenile male domestic chickens after 4 days' photostimulation. the most robust change was a depression in heat shock protein 90b1 (hsp90b1) expression. this observation was confirmed using quantitative pcr, and it was subsequently demonstrated that the depression in hsp90b1 expression ... | 2009 | 19429192 |
| spinal anesthesia with isobaric tetracaine in patients with previous lumbar spinal surgery. | previous lumbar spinal surgery (plss) is not currently considered as a contraindication for regional anesthesia. however, there are still problems that make spinal anesthesia more difficult with a possibility of worsening the patient's back pain. spinal anesthesia using combined spinal-epidural anesthesia (csea) in elderly patients with or without plss was investigated and the anesthetic characteristics, success rates, and possible complications were evaluated. | 2009 | 19430559 |
| thyroxine alone or thyroxine plus triiodothyronine replacement therapy for hypothyroidism. | standard therapy for patients with hypothyroidism is replacement with synthetic thyroxine (t4). however, thyroxine plus triiodothyronine (t3) replacement therapy resulted in marked improvements in several items of the profile of mood states and in a few indices of psychometric function and quality of life. the adequacy of thyroxine alone versus thyroxine plus triiodothyronine to treat hypothyroidism has yielded conflicting results. therefore, we conducted a systematic review of all included publ ... | 2009 | 19491714 |
| probing protein folding using site-specifically encoded unnatural amino acids as fret donors with tryptophan. | the experimental study of protein folding is enhanced by the use of nonintrusive probes that are sensitive to local conformational changes in the protein structure. here, we report the selection of an aminoacyl-trna synthetase/trna pair for the cotranslational, site-specific incorporation of two unnatural amino acids that can function as fluorescence resonance energy transfer (fret) donors with trp to probe the disruption of the hydrophobic core upon protein unfolding. l-4-cyanophenylalanine (pc ... | 2009 | 19492814 |
| three-dimensional reconstruction of biological macromolecular complexes from in-lens scanning electron micrographs. | two helical samples: f-actin and the bacteriophage t4 tail sheath were reconstructed in three dimensions from contrast enhanced (rotational shadowing and negatively stained) in-lens cryo-field emission scanning electron micrographs, using the iterative real-space helical reconstruction method. the f-actin--and bacteriophage t4 reconstructions compare favourably to an atomic model refined against fibre diffraction data and a cryo-electron microscopy reconstruction, respectively. these results sho ... | 2009 | 19493107 |
| relationship between the expression of toll-like receptor 2 and 4 in mononuclear cells and postoperative acute lung injury in orthotopic liver transplantation. | the aim of this study was to investigate the potential relationship between the dynamic expression of toll-like receptor 2 and 4 (tlr2/4) in peripheral blood mononuclear cells as well as changes in serum concentration of inflammatory factors and acute lung injury (ali) in patients after orthotopic liver transplantation (olt). | 2009 | 19493410 |
| obesity and thyrotropinemia. | to study the relation between body mass index (bmi) and tsh in euthyroid and subclinical hypothyroid obese children and compared serum tsh level among obese and overweight children. | 2009 | 19475347 |
| simultaneous determination of anti-diabetes/anti-obesity drugs by lc/pda, and targeted analysis of sibutramine analog in dietary supplements by lc/ms/ms. | the safety of dietary supplements is questionable as there have been occasional reports of products contaminated with illegal adulterants. the present study was carried out to develop trustworthy methodologies to screen for six anti-diabetic drugs (phenformin, rosiglitazone, glipizide, glimepiride, glybenclamide and gliclazide) and six anti-obesity drugs (ephedrine, fenfluramine, t3, t4, fluoxetine and sibutramine) in dietary supplements. a simultaneous determination method of the 12 drugs by li ... | 2009 | 19475544 |
| appropriate selection of patients for combined organ resection in cases of gastric carcinoma invading adjacent organs. | proper patient selection for multi-organ resection in t4 gastric carcinoma remains controversial. our aim was to investigate which patients might benefit from multi-organ resection. | 2009 | 19475581 |
| association of kyphosis and spinal skeletal abnormalities with intrathoracic stomach: a link toward understanding its pathogenesis. | modern-day concepts about the pathogenesis of an intrathoracic stomach include crural diaphragm muscular deterioration, loss of phrenoesophageal ligament integrity, and presence of abdominothoracic pressure gradients. the role of spinal abnormalities has received little attention. based on clinical observation, we hypothesized that kyphosis and other spinal diseases are components of the pathophysiology of an intrathoracic stomach. | 2009 | 19476791 |
| adjuvant chemoradiation therapy for pancreatic adenocarcinoma: who really benefits? | the role of adjuvant chemoradiation therapy (crt) in pancreatic cancer remains controversial. the primary aim of this study was to determine if crt improved survival in patients with resected pancreatic cancer in a large, multiinstitutional cohort of patients. | 2009 | 19476845 |
| epidural spinal cord compression with neurologic deficit associated with intrapedicular application of hemostatic gelatin matrix during pedicle screw insertion. | case report. | 2009 | 19478651 |
| the relationship between smoking machine derived tar yields and biomarkers of exposure in adult cigarette smokers in the us. | comprehensive data on human exposure to smoke constituents from different machine-measured tar yield cigarettes is limited. methods: this study used a stratified, cross-sectional, multi-center design to estimate biomarkers of exposure (boe) from nicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (nnk), pyrene, co, acrolein, and 1,3-butadiene and their relationship to tar yield categories of cigarette in adult smokers in the u.s. 3625 adults smokers were enrolled into four tar categories < ... | 2009 | 19481578 |
| angiofollicular lymph node hyperplasia resembling a spinal nerve sheath tumor: a rare case of castleman's disease. | angiofollicular lymph node hyperplasia (castleman's disease) is a lymphoproliferative disorder of unknown etiology. although uncommon, the localized form of this disease can manifest in the central nervous system, typically as a meningeal-based intracranial lesion. castleman's disease involving the spine is exceedingly rare. this represents only the second reported case of a patient with castleman's disease whose presentation mimicked that of a spinal nerve sheath tumor. | 2009 | 19482516 |
| recombinant human granulocyte-macrophage colony-stimulating factor (gm-csf, sargramostim) administered for 3 years as adjuvant therapy of stages ii(t4), iii, and iv melanoma. | a hypothesis generating study was conducted to evaluate the safety and efficacy of prolonged (3 y) administration of granulocyte-macrophage colony-stimulating factor (gm-csf, sargramostim) as surgical adjuvant therapy in patients with melanoma at high risk of recurrence. ninety-eight evaluable patients with stages ii(t4), iii, or iv melanoma were given prolonged treatment with gm-csf after surgical resection of disease. the gm-csf was administered subcutaneously in 28-day cycles, such that a dos ... | 2009 | 19483646 |
| report of an hiv and hhv-8 negative case of primary effusion lymphoma with idiopathic t4 lymphocytopenia. | although primary effusion lymphoma (pel) is usually associated with human herpes virus-8/kaposi sarcoma herpes virus (hhv-8/kshv) and human immunodeficiency virus (hiv), there are several reports of hhv-8/kshv and hiv negative cases, mainly in the setting of immunodeficiency. here, we report the second case of pel associated with idiopathic t4 lymphocytopenia (icl), which was hhv-8/kshv negative, hiv negative and epstein-barr virus positive, while no other causative agents for immunodeficiency w ... | 2009 | 19484335 |
| thyroid function and autoantibody status among women who spontaneously deliver under 35 weeks of gestation. | recent studies report an association between maternal thyroid auto-antibodies and preterm birth. none have made the important distinction between spontaneous and iatrogenic preterm birth. we investigated the association between spontaneous preterm birth before 35-week gestation and both thyroid function and auto-antibody status. | 2009 | 19486018 |
| a 7-year experience with low blood tsh cutoff levels for neonatal screening reveals an unsuspected frequency of congenital hypothyroidism (ch). | the guidelines of the national academy of clinical biochemistry advocated the use of low bloodspot tsh (b-tsh) threshold for newborn screening of congenital hypothyroidism (ch). the impact generated by the application of this indication is largely unknown. | 2009 | 19486019 |
| demographical aspects of schmorl nodes: a skeletal study. | a descriptive study of the association between schmorl nodes (sns) and gender, ethnic origin, and age in a normal skeletal population. | 2009 | 19531985 |
| expression of hepatocyte growth factor and basic fibroblast growth factor as prognostic indicators in gastric cancer. | we have investigated the correlations among hepatocyte growth factor (hgf) mrna expression, basic fibroblast growth factor (bfgf) mrna expression, tumor microvessel density (mvd), and clinical pathological features of gastric cancer in chinese patients. in situ hybridization was used to detect the expression of hgf and bfgf mrnas, and immunohistochemistry was used to detect cd34 in 105 gastric cancer tissues and in 20 normal control tissues. the rate of hgf mrna expression in normal gastric tiss ... | 2009 | 19533745 |
| three new types of interpenetrating sphere packings. | three new types of homogeneous interpenetrating sphere packings are described. in the general position of space group ccce, two sphere packings of type 3/10/o1 can be combined to form interpenetrating sphere packings of type o[3/10/o1]2. the other two types of interpenetrating sphere packings show symmetry fddd: two packings of type 3/10/t4 are intertwined in o[3/10/t4]2 and three packings of type 3/4/t1 in o[3/4/t1]3. | 2009 | 19535855 |
| competitive inhibition of thyroidal uptake of dietary iodide by perchlorate does not describe perturbations in rat serum total t4 and tsh. | perchlorate (clo4(-)) is an environmental contaminant known to disrupt the thyroid axis of many terrestrial and aquatic species. clo4(-) competitively inhibits iodide uptake into the thyroid at the sodium/iodide symporter and disrupts hypothalamic-pituitary-thyroid (hpt) axis homeostasis in rodents. | 2009 | 19479014 |
| comparative genomics of marine cyanomyoviruses reveals the widespread occurrence of synechococcus host genes localized to a hyperplastic region: implications for mechanisms of cyanophage evolution. | the vast majority of cyanophages isolated to date are cyanomyoviruses, a group related to bacteriophage t4. comparative genome analysis of five cyanomyoviruses, including a newly sequenced cyanophage s-rsm4, revealed a 'core genome' of 64 genes, the majority of which are also found in other t4-like phages. subsequent comparative genomic hybridization analysis using a pilot microarray showed that a number of 'host' genes are widespread in cyanomyovirus isolates. furthermore, a hyperplastic region ... | 2009 | 19508343 |
| evaluation of thoracic pedicle screw placement in adolescent idiopathic scoliosis. | pedicle screw fixation is a challenging procedure in thoracic spine, as inadvertently misplaced screws have high risk of complications. the accuracy of pedicle screws is typically defined as the screws axis being fully contained within the cortices of the pedicle. one hundred and eighty-five thoracic pedicle screws in 19 patients that were drawn from a total of 1.797 screws in 148 scoliosis patients being suspicious of medial and lateral malpositioning were investigated, retrospectively. screw c ... | 2009 | 19526376 |
| [impact of shengmal injection on changes of immunological function in patients after cardiopulmonary bypass]. | to study the impact and mechanism of shengmai injection (smi) on the immunological function changes after cardiopulmonary bypass. | 2009 | 19526756 |
| cdna display: a novel screening method for functional disulfide-rich peptides by solid-phase synthesis and stabilization of mrna-protein fusions. | we report a robust display technology for the screening of disulfide-rich peptides, based on cdna-protein fusions, by developing a novel and versatile puromycin-linker dna. this linker comprises four major portions: a 'ligation site' for t4 rna ligase, a 'biotin site' for solid-phase handling, a 'reverse transcription primer site' for the efficient and rapid conversion from an unstable mrna-protein fusion (mrna display) to a stable mrna/cdna-protein fusion (cdna display) whose cdna is covalently ... | 2009 | 19528071 |
| antitumor effect of combined treatment of mice with cytostatic agents and bacteriophage t4. | the past few years have shown significant resurgent interest in the old concept of bacteriophage therapy. some research groups continue to develop whole bacteriophage preparations as alternatives to antibiotic antibacterial treatment. however, improvements in the methods of purification of phage preparations open new opportunities in the successful treatment of antibiotic-resistant bacterial infections. an open question remains on whether bacteriophage preparations (bp) can be safely applied in ... | 2009 | 19528503 |
| responses of hematological parameters and aerobic performance of elite men and women swimmers during a 14-week training program. | the main purpose of the present investigation was to verify the responses of hematological parameters in men and women competitive swimmers during a 14-week training program. twenty-three olympic and international athletes were evaluated 4 times during the experiment: at the beginning of the endurance training phase (t1), at the end of the endurance training phase (t2), at the end of the quality phases (t3), and at the end of the taper period (t4). on the first day at 8:00 am, each swimmer had a ... | 2009 | 19528852 |
| effects of thyroxine replacement on serum creatinine and cystatin c in patients with primary and central hypothyroidism. | serum cystatin c (cysc) is a marker for kidney function, possibly superior to serum creatinine (cr). cr is increased and cysc decreased in primary hypothyroidism; these changes are reversed upon thyroxine (t4) replacement therapy. this (pilot) study was performed to see whether these opposing changes of cysc and cr could be confirmed in patients with central hypothyroidism. | 2009 | 19529992 |
| value of multidetector-row computed tomography in the preoperative t and n staging of gastric carcinoma: a large-scale chinese study. | to investigate the value of multidetector-row computed tomography (mdct) in the preoperative t and n staging of gastric carcinoma and to further investigate the clinicopathological factors affecting the diagnostic accuracy. | 2009 | 19530124 |
| polychlorinated biphenyls affect thyroid function and induce autoimmunity in sprague-dawley rats. | polychlorinated biphenyls (pcbs) have been reported to cause a variety of toxic effects. in order to assess the thyroid function after exposure to pcbs and investigate whether pcbs induce autoimmune process in the thyroid gland, we determined the levels of serum thyroid hormones (ft3, ft4, and t4), thyroid-stimulating hormone (tsh), and thyroid peroxidase antibody (tpoab) in sprague-dawley rats treated with a commercial mixture of pcbs, aroclor 1,254 (pcbs group), or the antithyroid drug, propyl ... | 2009 | 19530273 |
| [the role of thyroid hypofunction in development of metabolic syndrome]. | to study the role of hypothyroidism and concomitant obesity in the development of metabolic syndrome (ms). | 2009 | 19514426 |
| dorsal spinal cord stimulation obtunds the capacity of intrathoracic extracardiac neurons to transduce myocardial ischemia. | populations of intrathoracic extracardiac neurons transduce myocardial ischemia, thereby contributing to sympathetic control of regional cardiac indices during such pathology. our objective was to determine whether electrical neuromodulation using spinal cord stimulation (scs) modulates such local reflex control. in 10 anesthetized canines, middle cervical ganglion neurons were identified that transduce the ventricular milieu. their capacity to transduce a global (rapid ventricular pacing) vs. r ... | 2009 | 19515981 |
| nonadditivity in the recognition of single-stranded dna by the schizosaccharomyces pombe protection of telomeres 1 dna-binding domain, pot1-dbd. | the schizosaccharomyces pombe protection of telomeres 1 (sppot1) protein recognizes the 3' single-stranded ends of telomeres and provides essential protective and regulatory functions. the ssdna-binding activity of sppot1 is conferred by its ssdna-binding domain, pot1-dbd (residues 1-389), which can be further separated into two distinct domains, pot1pn (residues 1-187) and pot1pc (residues 188-389). here we show that pot1pc, like pot1pn, can function independently of pot1-dbd and binds specific ... | 2009 | 19518131 |
| the structure of gene product 6 of bacteriophage t4, the hinge-pin of the baseplate. | the baseplate of bacteriophage t4 is a multicomponent protein complex, which controls phage attachment to the host. it assembles from six wedges and a central hub. during infection the baseplate undergoes a large conformational change from a dome-shaped to a flat, star-shaped structure. we report the crystal structure of the c-terminal half of gene product (gp) 6 and investigate its motion with respect to the other proteins during the baseplate rearrangement. six gp6 dimers interdigitate, formin ... | 2009 | 19523898 |
| [locally advanced (neglected) breast cancer: the reality? relevance of two cases and reflection how to optimise the multidisciplinary approach]. | the standard treatment for breast cancer patients with untreated locally advanced breast cancer is neo-adjuvant chemotherapy or hormonal treatment. in some cases, this treatment is followed by surgery and/or radiotherapy when the multidisciplinary approach is present. in some cases of patients presenting metastatic diseases, the radiotherapy is forgotten or proposed late when the local disease is extremely advanced with symptoms and decreased quality of life. two cases of extremely advanced non ... | 2009 | 19524471 |
| thyroid hormones and personality traits in attempted suicide. | the research on thyroid hormones and personality traits is quite sparse and mainly focused on male forensic psychiatric populations in which the relationship between thyroid hormones and psychopathy and aggression-related personality traits has been reported. the suicidal temperament hypothesis suggests that certain personality traits such as aggression, anxiety proneness, impulsivity, and low socialization may render an individual vulnerable to the risk of suicide. the aim of this study was to ... | 2009 | 19525070 |
| preoperative radiochemotherapy in the treatment of advanced oral cancer: outcome of 276 patients. | the aim of this study was to review survival and locoregional control in patients with advanced oral and oropharyngeal squamous cell carcinoma treated by multimodal therapy with preoperative radiochemotherapy and radical surgery. | 2009 | 19525119 |
| chemoselection as a strategy for organ preservation in patients with t4 laryngeal squamous cell carcinoma with cartilage invasion. | high rates of overall survival (os) and laryngeal preservation were achieved in two sequential phase ii clinical trials in patients with stage iii/iv laryngeal squamous cell carcinoma (scc). patients were treated with chemoradiation after a >50% primary tumor response to one cycle of neoadjuvant chemotherapy (ic). we analyzed outcomes for t4 patients with cartilage invasion from both studies. | 2009 | 19504552 |
| synthesis of semitelechelic maleimide poly(pega) for protein conjugation by raft polymerization. | maleimide end functionalized polymers for site-selective conjugation to free cysteines of proteins were synthesized using reversible addition-fragmentation chain transfer (raft) polymerization. a furan-protected maleimide chain transfer agent (cta) was employed in the raft polymerization of poly(ethylene glycol) methyl ether acrylate (pega). gel permeation chromatography (gpc) with laser light scattering detection indicated that 20,000 and 39,000 da polypega had been made with polydispersity ind ... | 2009 | 19505142 |
| thyroid hormone levels associated with active and passive cigarette smoking. | active and passive cigarette smoking are a risk factor among women of reproductive age-leading to reproductive health morbidity, including fetal and infant death and developmental problems with the newborn. however, the underlying physiological mechanisms for these ill-effects are not fully understood. smoke exposure may affect various metabolic and biological processes, including hormone biosynthesis and secretion, interfere with thyroid hormone release, binding, transport, storage, and clearan ... | 2009 | 19505184 |
| molecular components underlying nongenomic thyroid hormone signaling in embryonic zebrafish neurons. | neurodevelopment requires thyroid hormone, yet the mechanisms and targets of thyroid hormone action during embryonic stages remain ill-defined. we previously showed that the thyroid hormone thyroxine (t4) rapidly increases voltage-gated sodium current in zebrafish rohon-beard cells (rbs), a primary sensory neuron subtype present during embryonic development. here, we determined essential components of the rapid t4 signaling pathway by identifying the involved intracellular messengers, the target ... | 2009 | 19505305 |
| genotyping of trim5 locus in northern pig-tailed macaques (macaca leonina), a primate species susceptible to human immunodeficiency virus type 1 infection. | the pig-tailed macaques are the only old world monkeys known to be susceptible to human immunodeficiency virus type 1 (hiv-1) infection. we have previously reported that the trim5-cyclophilin a (trimcyp) fusion in pig-tailed macaques (macaca nemestrina) is dysfunctional in restricting hiv-1, which may explain why pig-tailed macaques are susceptible to hiv-1 infection. similar results have also been reported by other groups. however, according to the current primate taxonomy, the previously repor ... | 2009 | 19505341 |
| longitudinal evaluation of patients with a homozygous r450h mutation of the tsh receptor gene. | the r450h mutation of the tsh receptor (tshr) gene has been frequently observed in japanese patients with resistance to tsh. the purpose of this study was to clarify the phenotype of patients with a homozygous r450h mutation of the tshr gene; the mutant receptor has previously demonstrated moderately impaired function in vitro. | 2009 | 19506388 |