Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| herpesvirus carriage in saliva and posttreatment apical periodontitis: searching for association. | objective: herpesvirus infection can cause immunosuppression and then act as a modifier of apical periodontitis, influencing the disease severity and response to treatment. the purpose of this study was to investigate if herpesvirus infection, as inferred by salivary carriage, may influence the endodontic treatment outcome. study design: the study population included 72 patients who had root canals treated more than 1 year previously because of necrotic pulps and apical periodontitis. at the fol ... | 2011 | 21831677 |
| 'spontaneous molecular reactivation' of herpes simplex virus type 1 in the brain as a pathogenic mechanism of alzheimer's disease. | 2011 | 21700397 | |
| Analysis of Rab GTPase-activating proteins indicates that Rab1a/b and Rab43 are important for herpes simplex virus 1 secondary envelopment. | Assembly of herpes simplex virus 1 (HSV-1) occurs in the cytoplasm, where the capsid and tegument bud into host cell membranes. It is at this point that the viral glycoproteins are incorporated into the virion, as they are located at the assembly site. We investigated the role of the Rab GTPases in coordinating the assembly process by overexpressing 37 human Rab GTPase-activating proteins (GAPs) and assessing infectious titers. Rab GTPases are key cellular regulators of membrane trafficking even ... | 2011 | 21680502 |
| human hepatocyte growth factor promotes functional recovery in primates after spinal cord injury. | many therapeutic interventions for spinal cord injury (sci) using neurotrophic factors have focused on reducing the area damaged by secondary, post-injury degeneration, to promote functional recovery. hepatocyte growth factor (hgf), which is a potent mitogen for mature hepatocytes and a mediator of the inflammatory responses to tissue injury, was recently highlighted as a potent neurotrophic factor in the central nervous system. we previously reported that introducing exogenous hgf into the inju ... | 2011 | 22140459 |
| clinical characteristics of patients with epstein barr virus in cerebrospinal fluid. | the role of epstein-barr (ebv) virus in central nervous system (cns) infections is not fully resolved. it is clearly associated with lymphoproliferative disease of immunosuppressed persons, and may cause encephalitis. | 2011 | 22018204 |
| Effect of ultrasound on herpes simplex virus infection in cell culture. | Ultrasound has been shown to increase the efficiency of gene expression from retroviruses, adenoviruses and adeno-associated viruses. The effect of ultrasound to stimulate cell membrane permeabilization on infection with an oncolytic herpes simplex virus type 1 (HSV-1) was examined. | 2011 | 21939524 |
| genetic factors influence serological measures of common infections. | antibodies against infectious pathogens provide information on past or present exposure to infectious agents. while host genetic factors are known to affect the immune response, the influence of genetic factors on antibody levels to common infectious agents is largely unknown. here we test whether antibody levels for 13 common infections are significantly heritable. | 2011 | 21996708 |
| ocular herpes simplex virus: how are latency, reactivation, recurrent disease and therapy interrelated? | most humans are infected with herpes simplex virus (hsv) type 1 in early childhood and remain latently infected throughout life. while most individuals have mild or no symptoms, some will develop destructive hsv keratitis. ocular infection with hsv-1 and its associated sequelae account for the majority of corneal blindness in industrialized nations. neuronal latency in the peripheral ganglia is established when transcription of the viral genome is repressed (silenced) except for the latency-asso ... | 2011 | 21861620 |
| functional genomics reveals an essential and specific role for stat1 in protection of the central nervous system following herpes simplex virus corneal infection. | innate immune deficiencies result in a spectrum of severe clinical outcomes following infection. in particular, there is a strong association between loss of the signal transducer and activator of transcription (stat) pathway, breach of the blood-brain barrier (bbb), and virus-induced neuropathology. the gene signatures that characterize resistance, disease, and mortality in the virus-infected nervous system have not been defined. herpes simplex virus type 1 (hsv-1) is commonly associated with e ... | 2011 | 21994441 |
| An important role for syndecan-1 in herpes simplex virus type-1 induced cell-to-cell fusion and virus spread. | Herpes simplex virus type-1 (HSV-1) is a common human pathogen that relies heavily on cell-to-cell spread for establishing a lifelong latent infection. Molecular aspects of HSV-1 entry into host cells have been well studied; however, the molecular details of the spread of the virus from cell-to-cell remain poorly understood. In the past, the role of heparan sulfate proteoglycans (HSPG) during HSV-1 infection has focused solely on the role of HS chains as an attachment receptor for the virus, whi ... | 2011 | 21957484 |
| Herpetic blepharitis and inhaled budesonide. | 2011 | 22136691 | |
| c21orf91 genotypes correlate with herpes simplex labialis (cold sore) frequency: description of a cold sore susceptibility gene. | herpes simplex virus type 1 (hsv-1) infects >70% of the united states population. we identified a 3-megabase region on human chromosome 21 containing 6 candidate genes associated with herpes simplex labialis (hsl, "cold sores"). | 2011 | 22039568 |
| serum antibodies to toxoplasma gondii and herpesvidae family viruses in individuals with schizophrenia and bipolar disorder: a case-control study. | recent etiological studies for schizophrenia and bipolar disorder have focused on the protozoan toxoplasma gondii and herpesvirdae family viruses. | 2011 | 21991754 |
| real-time pcr detection of human herpesvirus 1-5 in patients lacking clinical signs of a viral cns infection. | infections of the central nervous system (cns) with herpes- or enterovirus can be self-limiting and benign, but occasionally result in severe and fatal disease. the polymerase chain reaction (pcr) has revolutionized the diagnostics of viral pathogens, and by multiple displacement amplification (mda) prior to real-time pcr the sensitivity might be further enhanced. the aim of this study was to investigate if herpes- or enterovirus can be detected in cerebrospinal fluid (csf) from patients without ... | 2011 | 21849074 |
| genetic editing of herpes simplex 1 and epstein barr herpesvirus genomes by human apobec-3 cytidine deaminases in culture and in vivo. | human apobec3 cytidine deaminases target and edit single stranded dna, which can be of viral, mitochondrial or nuclear origin. retroviral genomes such as human immunodeficiency virus (hiv) genomes deficient in the vif gene and hepatitis b virus are particularly vulnerable. the genomes of dna viruses such as human papillomaviruses can be edited in vivo and in transfection experiments. accordingly herpesviruses should be no exception. this is indeed the case for herpes simplex virus type 1 (hsv-1) ... | 2011 | 21632763 |
| herpes simplex virus 1 glycoprotein b and us3 collaborate to inhibit cd1d antigen presentation and nkt cell function. | herpes simplex viruses (hsvs) are prevalent human pathogens that establish latency in human neuronal cells and efficiently evade the immune system. it has been a major medical challenge to eradicate them and, despite intensive efforts, an effective vaccine is not available. we previously showed that upon infection of antigen-presenting cells, hsv type 1 (hsv-1) rapidly and efficiently downregulates the major histocompatibility complex class i-like antigen-presenting molecule, cd1d, and potently ... | 2011 | 21653669 |
| a novel fusogenic herpes simplex virus for oncolytic virotherapy of squamous cell carcinoma. | r849 is a neurovirulent ╬│ôéü34.5 gene-deficient form of herpes simplex virus type 1 (hsv-1) and has lacz genes at the deleted sites of the ╬│ôéü34.5 gene. hf is a spontaneously occurring, fusogenic hsv-1 strain. the purpose of this work was to generate a virus that has the syncytial character of hf, while preserving the ╬│ôéü34.5 gene inactivation profile of r849 virus. | 2011 | 21663640 |
| tyrosine-based 1-(s)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((s)-hpmpc and (s)-hpmpa) prodrugs: synthesis, stability, antiviral activity, and in vivo transport studies. | eight novel single amino acid (6-11) and dipeptide (12, 13) tyrosine p-o esters of cyclic cidofovir ((s)-chpmpc , 4) and its cyclic adenine analogue ((s)-chpmpa, 3) were synthesized and evaluated as prodrugs. in vitro ic(50) values for the prodrugs (<0.1-50 μm) vs vaccinia, cowpox, human cytomegalovirus, and herpes simplex type 1 virus were compared to those for the parent drugs ((s)-hpmpc, 2; (s)-hpmpa, 1; ic(50) 0.3-35 μm); there was no cytoxicity with kb or hff cells at ≤100 μm. the prodrugs ... | 2011 | 21812420 |
| expression of hsv-1 encoded mirnas in human trigeminal ganglia and their relation to local t-cell infiltrates. | herpes simplex type-1 (hsv-1) is a neurotropic virus which establishes lifelong latency in human trigeminal ganglia (tg). currently, two non-exclusive control mechanisms of hsv-1 latency are discussed: anti-viral cd8(+) t cells and viral micro rnas (mirna) encoded by the latency associated transcript (lat). here we investigate to what extent these mechanisms may contribute to the maintenance of hsv-1 latency. in the current study we show, that only a small proportion of lat(+) neurons is surroun ... | 2011 | 21795359 |
| herpes simplex virus type 1 penetrates the basement membrane in human nasal respiratory mucosa. | herpes simplex virus infections are highly prevalent in humans. however, the current therapeutics suffer important drawbacks such as limited results in neonates, increasing occurrence of resistance and impeded treatment of stromal infections. remarkably, interactions of herpesviruses with human mucosa, the locus of infection, remain poorly understood and the underlying mechanisms in stromal infection remain controversial. | 2011 | 21789229 |
| Activation of Autophagy by a-herpesviruses in myeloid cells is mediated by cytoplasmic viral DNA through a mechanism dependent on stimulator of IFN genes. | Autophagy has been established as a player in host defense against viruses. The mechanisms by which the host induces autophagy during infection are diverse. In the case of HSV type 1 (HSV-1), dsRNA-dependent protein kinase is essential for induction of autophagy in fibroblasts through phosphorylation of eukaryotic initiation factor 2a (eIF2a). HSV-1 counteracts autophagy via ICP34.5, which dephosphorylates eIF2a and inhibits Beclin 1. Investigation of autophagy during HSV-1 infection has largely ... | 2011 | 21998456 |
| aerobic fitness is associated with lower proportions of senescent blood t-cells in man. | senescent t-cells accumulate with age, lowering the naïve t-cell repertoire and increasing host infection risk. as this response is likely to be influenced by certain lifestyle factors, we examined the association between aerobic fitness (vo(2max)) and the age-related accumulation of senescent t-cells. blood lymphocytes from 102 healthy males (18-61yr) were analyzed for klrg1, cd57, cd28, cd45ra, cd45ro surface expression on cd4+ and cd8+ t-cells by 4-color flow cytometry. advancing age (yr) was ... | 2011 | 21784146 |
| divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism. | viruses rely on the metabolic network of the host cell to provide energy and macromolecular precursors to fuel viral replication. here we used mass spectrometry to examine the impact of two related herpesviruses, human cytomegalovirus (hcmv) and herpes simplex virus type-1 (hsv-1), on the metabolism of fibroblast and epithelial host cells. each virus triggered strong metabolic changes that were conserved across different host cell types. the metabolic effects of the two viruses were, however, la ... | 2011 | 21779165 |
| nuclear envelope breakdown can substitute for primary envelopment-mediated nuclear egress of herpesviruses. | herpesvirus nucleocapsids assemble in the nucleus but mature to infectious virions in the cytoplasm. to gain access to this cellular compartment, nucleocapsids are translocated to the cytoplasm by primary envelopment at the inner nuclear membrane and subsequent fusion of the primary envelope with the outer nuclear membrane. the conserved viral pul34 and pul31 proteins play a crucial role in this process. in their absence, viral replication is strongly impaired but not totally abolished. we used ... | 2011 | 21680518 |
| the histone acetyltransferase clock is an essential component of the herpes simplex virus 1 transcriptome that includes tfiid, icp4, icp27, and icp22. | studies published elsewhere have shown that the herpes simplex virus regulatory protein icp0 interacts with bmal1, a partner and regulator of circadian histone acetyltransferase clock, that both proteins localize at nd10 bodies and are stabilized by viral proteins, that enzymatically active clock partially complements +öicp0 mutants, and that silencing of clock suppresses the expression of viral genes. here we report that clock is a component of the transcriptional complex that includes tfiid, i ... | 2011 | 21734043 |
| antiviral activities of sulfated polysaccharides isolated from sphaerococcus coronopifolius (rhodophytha, gigartinales) and boergeseniella thuyoides (rhodophyta, ceramiales). | water-soluble sulfated polysaccharides isolated from two red algae sphaerococcus coronopifolius (gigartinales, sphaerococcaceae) and boergeseniella thuyoides (ceramiales, rhodomelaceae) collected on the coast of morocco inhibited in vitro replication of the human immunodeficiency virus (hiv) at 12.5 ++g/ml. in addition, polysaccharides were capable of inhibiting the in vitro replication of herpes simplex virus type 1 (hsv-1) on vero cells values of ec(50) of 4.1 and 17.2 ++g/ml, respectively. th ... | 2011 | 21822410 |
| [in vitro study on the anti-hsv-1 and hbv activities of extracts from the fruit of eucalyptus maidenii]. | to investigate the antiviral activities of three kinds of extracts from the fruit of eucalyptus maidenii against herpes simplex virus typel and hepatitis b virus. | 2011 | 21823484 |
| antitumor effect of orlistat, a fatty acid synthase inhibitor, is via activation of caspase-3 on human colorectal carcinoma-bearing animal. | we established a ht-29/tk-luc human colorectal carcinoma-bearing animal model for the study of the inhibition effect and mechanism of orlistat, a fatty acid synthase (fasn) inhibitor. the results showed that orlistat caused cell cycle arrest at g1 phase, and triggered apoptosis through caspase-3 activation. the tumor inhibition effect of orlistat may also due to the inhibition of fatty acid synthesis without altering fasn activity. the tumor size of orlistat-treated mice in vivo was significantl ... | 2011 | 21723078 |
| conversion of trichosanthin-induced cd95 (fas) type i into type ii apoptotic signaling during herpes simplex virus infection. | trichosanthin (tcs) is a type i ribosome-inactivating protein with wide spectrum of pharmacological activities. it inhibits human immunodeficiency virus type 1 (hiv-1) and herpes simplex virus type 1 (hsv-1) replication but the mechanism is not clear. from a previous study, tcs was found to be more cytotoxic to hiv-1 infected cells than uninfected cells. similar finding was confirmed with hsv-1 in the present study. tcs induced cell death in hep-2 cells and the ec(50) was 24.64++g/ml. when the s ... | 2011 | 21723610 |
| novel 1,2,4-triazole and purine acyclic cyclopropane nucleoside analogues: synthesis, antiviral and cytostatic activity evaluations. | several published studies indicate that the acyclic guanine nucleoside analogues possessing bis(1,2-hydroxymethyl) substituted cyclopropane rings mimicking the sugar moiety are potent inhibitors of replication of several herpes viruses. | 2011 | 21730369 |
| restrictions that control herpes simplex virus type 1 infection in mouse brain ex-vivo. | elucidating the cellular and molecular factors governing hsv-1 neurotropism is a prerequisite for understanding hsv-1 encephalitis and for targeting hsv-1-derived vectors for gene transfer to the brain. earlier we have described an ex-vivo system of mouse brain slices and demonstrated a selective and unique infection pattern, mostly around the ventricles. here we examined tissue factors controlling hsv-1 infection of brain slices. we demonstrated that heparan sulphate, while an important factor, ... | 2011 | 21697348 |
| prurigo pigmentosa: a clinicopathological study and analysis of associated factors. | prurigo pigmentosa (pp), a rare inflammatory disease of the skin, is mostly reported in the ethnic japanese population. its pathogenesis remains unclear. the chronic and recurrent nature of pp implies a possible role of viral infection in the pathogenesis. the anti-inflammatory mechanism of doxycycline, which is well documented as a good treatment for pp, is related to the suppression of interleukin expression. | 2011 | 21182500 |
| structural basis for the recognition of cellular mrna export factor ref by herpes viral proteins hsv-1 icp27 and hvs orf57. | the herpesvirus proteins hsv-1 icp27 and hvs orf57 promote viral mrna export by utilizing the cellular mrna export machinery. this function is triggered by binding to proteins of the transcription-export (trex) complex, in particular to ref/aly which directs viral mrna to the tap/nfx1 pathway and, subsequently, to the nuclear pore for export to the cytoplasm. here we have determined the structure of the ref-icp27 interaction interface at atomic-resolution and provided a detailed comparison of th ... | 2011 | 21253573 |
| hsv-tk/gcv cancer suicide gene therapy by a designed recombinant multifunctional vector. | the objective of this research was to evaluate the efficacy of a recombinant nonviral vector for targeted delivery of a thymidine kinase (tk) suicide gene to xenograft skov-3 tumors. the vector was genetically engineered and used to condense the tk gene into particles of less than 100 nm. the nanoparticles were used to transfect and kill skov-3 cancer cells in combination with ganciclovir (gcv) in vitro. the results demonstrated that the vector could effectively kill up to 80% of the skov-3 canc ... | 2011 | 20817124 |
| proanthocyanidin-enriched extract from myrothamnus flabellifolia welw. exerts antiviral activity against herpes simplex virus type 1 by inhibition of viral adsorption and penetration. | extracts from the aerial parts of the south african resurrection plant myrothamnus flabellifolia welw. have been used traditionally against infections of the upper respiratory tract and skin diseases. a polyphenol-enriched extract was investigated for potential antiviral effects against herpes simplex virus type 1 (hsv-1) and adenovirus, and the underlying mode of action was to be studied. | 2011 | 21211557 |
| single tube multiplex real-time pcr for the rapid detection of herpesvirus infections of the central nervous system. | human herpesvirus infection of immunocompromised hosts may lead to central nervous system (cns) infection and diseases. in this study, a single tube multiplex real-time pcr was developed for the detection of five herpesviruses (hsv-1, hsv-2, vzv, ebv and cmv) in clinical cerebrospinal fluid (csf) specimens. two primer pairs specific for the herpesvirus polymerase gene and five hybridization probe pairs for the specific identification of the herpesvirus types were used in a lightcycler multiplex ... | 2011 | 21466846 |
| vitamin d status and antibody levels to common viruses in pediatric-onset multiple sclerosis. | the relative contribution and interaction of risk factors for multiple sclerosis (ms) have not been evaluated. objectives: to determine whether vitamin d status is associated with antibody levels to common viruses in pediatric-onset ms or clinically isolated syndrome (cis) patients and controls. | 2011 | 21212086 |
| herpes simplex virus requires vp11/12 to activate src family kinase-phosphoinositide 3-kinase-akt signaling. | we previously showed that the herpes simplex virus 1 (hsv-1) tegument protein vp11/12 activates the lymphocyte-specific src family kinase (sfk) lck and is tyrosine phosphorylated in an lck-dependent manner during t cell infection. we now extend these findings to show that ectopic expression of lck induces robust tyrosine phosphorylation of vp11/12 in vero cells, strongly suggesting that vp11/12 participates in an lck-mediated signaling pathway as a substrate of lck or a kinase activated by lck. ... | 2011 | 21228233 |
| a herpesvirus virulence factor inhibits dendritic cell maturation through protein phosphatase 1 and ikappa b kinase. | dendritic cells are sentinels in innate and adaptive immunity. upon virus infection, a complex program is in operation, which activates i?b kinase (ikk), a key regulator of inflammatory cytokines and costimulatory molecules. here we show that the ?(1)34.5 protein, a virulence factor of herpes simplex viruses, blocks toll-like receptor-mediated dendritic cell maturation. while the wild-type virus inhibits the induction of major histocompatibility complex (mhc) class ii, cd86, interleukin-6 (il-6) ... | 2011 | 21248029 |
| evolution of the antigen-specific cd8+ tcr repertoire across the life span: evidence for clonal homogenization of the old tcr repertoire. | defects in t cell responses against pathogens and reduced diversity of tcrs have been described at both extremes of the life span. yet, we still lack information on how ag-specific t cell populations are maintained and/or altered from birth to old age. in this study, for the first time to our knowledge, we provide insight into ag-specific tcr repertoire changes over the life span at the single-cell level. we have examined the tcr diversity of the primary cd8(+) t cell response to the immunodomin ... | 2011 | 21248263 |
| cellular snf2h chromatin-remodeling factor promotes herpes simplex virus 1 immediate-early gene expression and replication. | like other dna viruses that replicate in the nucleus, herpes simplex virus 1 (hsv-1) regulates the association of histones with its genome to promote viral replication and gene expression. we previously demonstrated that snf2h, a member of the iswi family of chromatin-remodeling factors, is concentrated in hsv-1 replication compartments in the nuclei of infected cells, suggesting that this cellular enzyme plays a role in viral replication. we show here that small interfering rna (sirna)-mediated ... | 2011 | 21249171 |
| exploitation of herpesviral transactivation allows quantitative reporter gene-based assessment of virus entry and neutralization. | herpesviral entry is a highly elaborated process requiring many proteins to act in precise conjunction. neutralizing antibodies interfere with this process to abrogate viral infection. based on promoter transactivation of a reporter gene we established a novel method to quantify herpesvirus entry and neutralization by antibodies. following infection with mouse and human cytomegalovirus and herpes simplex virus 1 we observed promoter transactivation resulting in substantial luciferase expression ... | 2011 | 21264213 |
| mir-101 regulates hsv-1 replication by targeting atp5b. | micrornas (mirnas) are short non-coding rnas that negatively modulate gene expression at the post-transcriptional level and are known to be involved in the cross-talk between the host and virus. using a standard plaque assay and real-time pcr method, we found that ectopic expression of mir-101 could significantly suppress herpes simplex virus-1 (hsv-1) replication, and that blocking endogenous mir-101 could increase viral progeny without affecting cell viability. bioinformatics analysis indicate ... | 2011 | 21291913 |
| review of the etiologies of viral meningitis and encephalitis in a dengue endemic region. | to evaluate the etiology of viral meningitis and encephalitis in adults and adolescents living in areas affected by dengue. | 2011 | 21292281 |
| in vitro cytotoxic and antiviral activities of ficus carica latex extracts. | the latex of fig fruit (ficus carica) is used in traditional medicine for the treatment of skin infections such as warts and also diseases of possible viral origin. five extracts (methanolic, hexanic, ethyl acetate, hexane-ethyl acetate (v/v) and chloroformic) of this species were investigated in vitro for their antiviral potential activity against herpes simplex type 1 (hsv-1), echovirus type 11 (ecv-11) and adenovirus (adv). to evaluate the capacity of the extracts to inhibit the replication o ... | 2011 | 21294043 |
| functional reorganization of promyelocytic leukemia nuclear bodies during bk virus infection. | bk virus (bkv) is the causative agent for polyomavirus-associated nephropathy, a severe disease found in renal transplant patients due to reactivation of a persistent bkv infection. bkv replication relies on the interactions of bkv with many nuclear components, and subnuclear structures such as promyelocytic leukemia nuclear bodies (pml-nbs) are known to play regulatory roles during a number of dna virus infections. in this study, we investigated the relationship between pml-nbs and bkv during i ... | 2011 | 21304169 |
| the role of lat in increased cd8+ t cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1. | herpes simplex virus (hsv) infection is a classic example of latent viral infection in humans and experimental animal models. the hsv-1 latency-associated transcript (lat) plays a major role in the hsv-1 latency reactivation cycle and thus in recurrent disease. whether the presence of lat leads to generation of dysfunctional t cell responses in the trigeminal ganglia (tg) of latently infected mice is not known. to address this issue, we used lat-positive [lat(+)] and lat-deficient [lat(-)] virus ... | 2011 | 21307196 |
| evaluation of tear samples for herpes simplex virus 1 (hsv) detection in suspected cases of viral keratitis using pcr assay and conventional laboratory diagnostic tools. | herpes simplex virus (hsv) keratitis is a leading cause of corneal blindness. definitive laboratory diagnosis is essential for timely management. collection of corneal scrapings in patients with advanced epithelial keratitis and corneal thinning poses perforation risks; tear fluid is a feasible and convenient alternative but has not been widely evaluated for hsv detection. | 2011 | 20852317 |
| tau cleavage at d421 by caspase-3 is induced in neurons and astrocytes infected with herpes simplex virus type 1. | herpes simplex virus type 1 (hsv-1) is ubiquitous, neurotropic, and the most common pathogenic causes of sporadic acute encephalitis in humans. herpes simplex encephalitis is associated with a high mortality rate and significant neurological, neuropsychological, and neurobehavioral sequelae, which afflict patients for life. hsv-1 infects limbic system structures in the central nervous system and has been suggested as an environmental risk factor for alzheimer's disease. however, the possible mec ... | 2011 | 21098975 |
| activity investigation of pinostrobin towards herpes simplex virus-1 as determined by atomic force microscopy. | in the present study, the antiviral activity of pinostrobin towards herpes simplex virus-1 (hsv-1) was investigated by mtt assay and atomic force microscopy. pinostrobin can inhibit hsv-1 replication with 50% effective concentration (ec(50)) of 22.71 ± 1.72 μg/ml. mtt assay showed hsv-1 was significantly inhibited when pretreated with pinostrobin, with the inhibition of 85.69 ± 2.59%. significant changes in morphology and size of hsv-1 were observed by atomic force microscopy (afm) in response t ... | 2011 | 20739162 |
| short-term viral exposure and memory. | 2011 | 20603634 | |
| role of human herpes virus 6 in corneal inflammation alone or with human herpesviruses. | : the purpose of this study was to determine the association of human herpes virus 6 (hhv-6) and/or other human herpesviruses in corneal inflammation using polymerase chain reaction (pcr). | 2011 | 20847652 |
| loop-mediated isothermal amplification assay for the diagnosis of retinitis caused by herpes simplex virus-1. | a loop-mediated isothermal amplification (lamp) assay was developed for the detection of herpes simplex virus 1 (hsv-1). the specificity of the assay was tested using dna extracted from hsv-1-infected rabbit corneal epithelium cultures, hsv-2 grown on vero cell line, cytomegalovirus (cmv) (ad-169), varicella zoster virus (vzv) (oka-vaccine), adenovirus, aspergillus flavus and staphylococcus aureus. the specificity of lamp was confirmed by bidirectional sequencing of the amplicons. the sensitivit ... | 2011 | 20298270 |
| association of allergic sensitization with infectious diseases burden in roma and non-roma children. | the hypothesis whether exposure to certain infections protects from atopy remains equivocal. to further investigate this, we compared serologic markers of infection and allergic sensitization prevalence in roma children, who live under unfavorable hygienic conditions that facilitate the spread of infections, and non-roma children who live in the same area. analyses included 98 roma and 118 non-roma children. serum igg antibodies for 13 foodborne- airborne- and bloodborne infectious agents were d ... | 2011 | 20573034 |
| Detection of herpes simplex virus (1 and 2), varicella-zoster virus, cytomegalovirus, human herpesvirus 6 and enterovirus in immunocompetent tunisian patients with acute neuromeningeal disorder. | Enteroviruses (EVs) and human herpesviruses (HHVs) are involved frequently in acute neurological disorders of viral etiology. This study aimed to investigate the incidence of herpes simplex virus types-1 (HSV-1) and 2 (HSV-2), varicella-zoster virus (VZV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6) and human enteroviruses (EVs) in cerebrospinal fluid (CSF) samples of Tunisian immunocompetent patients with neuromeningeal disorders. The patients had been hospitalized at the Fattouma Bourgu ... | 2012 | 22170549 |
| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |