Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| astragaloside iv improved barrier dysfunction induced by acute high glucose in human umbilical vein endothelial cells. | the purpose of the present study was to examine the effects of astragaloside iv, a saponin isolated from astragalus membranaceus (fisch) bge, on the impairment of barrier function induced by acute high glucose in cultured human vein endothelial cells. high glucose (27.8 mm) induced a decrease in transendothelial electrical impedance and an increase in cell monolayer permeability in human umbilical vein endothelial cells. endothelial barrier dysfunction stimulated by high glucose was accompanied ... | 2006 | 16650877 |
| cardiac protective effect of astragalus on viral myocarditis mice: comparison with perindopril. | in clinical practice, astragali radix (astragalus), the root of astragalus membranaceus bunge, has been widely applied to treat patients with viral diseases, including viral myocarditis in china. the present study was designed to evaluate the protective effects of astragalus on the function of sarcoplasmic reticulum calcium atpase (serca2) activity and endothelin system at acute and chronic periods of myocarditis mice induced by cvb(3) infection. astragalus feeding (2.2 mg/kg/day) could signific ... | 2006 | 16710898 |
| astragaloside iv dilates aortic vessels from normal and spontaneously hypertensive rats through endothelium-dependent and endothelium-independent ways. | the major active constituent of astragalus membranaceus, astragaloside iv, has been found to have properties of increasing coronary flow and cardioprotection. in this study, we examined the direct effects of astragaloside iv on vessel dilatation and contraction in isolated aortic rings from both normal and stroke-prone spontaneously hypertensive rats (shr-sp) in vitro. the results demonstrated that astragaloside iv could antagonize vessel contractions induced by phenylephrine and potassium chlor ... | 2006 | 16732512 |
| a novel antioxidant agent, astragalosides, prevents shock wave-induced renal oxidative injury in rabbits. | extracorporeal shock-wave lithotripsy (eswl)-induced renal damage can occur as a result of multiple mechanisms, including small vessel injury and free radical formation. our previous studies have demonstrated that astragalus membranaceus (am), a traditional chinese herb, could significantly alleviate shock wave-induced renal oxidative injury, and its renoprotective effects were superior to those of varapamil, a calcium antagonist, which were considered to be a powerful agent in treating renal da ... | 2006 | 16783584 |
| the effect of echinacea purpurea, astragalus membranaceus and glycyrrhiza glabra on cd69 expression and immune cell activation in humans. | the increasing use of medicinal herbs among the general public has piqued the need for scientific-based research to determine the mechanism of action of herbs administered orally in human subjects. the ability of three herbs, echinacea purpurea, astragalus membranaceus and glycyrrhiza glabra, to activate immune cells in human subjects was assessed in this pilot study. the effect of these herbs when ingested for 7 days was measured both when administered singly, and in combination, using flow cyt ... | 2006 | 16807880 |
| chemometric classification of traditional chinese medicines by their geographical origins using near-infrared reflectance spectra. | some raw materials that have different places of production for the plant sources of the drugs astragalus membranaceus and ginseng have been studied, based on their near-infrared reflectance spectra. the experimentally recorded spectra represent heavily ill-posed and highly correlative data sets. three related methods, i.e. the fisher linear discriminant analysis (flda), the ridge-type linear discriminant analysis (rlda) and a newly proposed penalized ridge-type linear discriminant analysis (prl ... | 2006 | 16896252 |
| inhibitory effects of astragaloside iv on diabetic peripheral neuropathy in rats. | astragaloside iv (ags-iv), a new glycoside of cycloartane-type triterpene isolated from the root of astragalus membranaceus (fisch.) bunge, has been used experimentally for its potent immune-stimulating, anti-inflammatory, and antioxidative actions. a recent study has shown ags-iv to be an aldose-reductase inhibitor and a free-radical scavenger. this study examined the effects of ags-iv on motor nerve conduction velocity (mncv), tailflick threshold temperature, biochemical indexes, and the histo ... | 2006 | 16900242 |
| [effect of 5-fluorouracil in combination with astragalus membranaceus on amino acid metabolism in mice model of gastric carcinoma]. | to study the effect of 5-fluorouracil-fu in combination with astragalus membranaceus(am) on amino acid metabolism in mice model of gastric carcinoma induced by 3-methylcholanthrene(mc). | 2006 | 17043971 |
| traditional chinese medicine bao gan ning increase phosphorylation of creb in liver fibrosis in vivo and in vitro. | previous studies have demonstrated that traditional chinese medicine bao gan ning, which contains six different drugs: trionyx sinensis wiegmann shell, prunus persica (l.) batsch seed, salvia miltiorrhiza bge. root, mallotus opelta (lour.) muell-arg root, astragalus membranaceus (fisch.) bge. var. mongho-licus (bge.) hsiao root and scutellaria baicalensis georgi root, was able to protect liver against fibrosis in ccl4 models. in an effort to elucidate molecular mechanisms by which bao gan ning e ... | 2006 | 16293380 |
| effects of astragalus membranaceus in promoting t-helper cell type 1 polarization and interferon-gamma production by up-regulating t-bet expression in patients with asthma. | to explore the effect of astragalus membranaceus (am) on t-helper cell type 1 (thl) specific transcription factor t-box expressed in t cells (t-bet) expression and thl/th2 equilibrium. | 2006 | 17361521 |
| [effects of astragalus membranaceus on th cell subset function in children with recurrent tonsillitis]. | to observe the th cell subset function in children with recurrent tonsillitis (rt) at the remission stage and to study the effects of astragalus membranacus (am) on th cell subset function. | 2006 | 17052394 |
| simultaneous analysis of seven astragalosides in radix astragali and related preparations by liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry. | a method has been developed for the qualitative and quantitative analysis of pharmacologically active astragalosides isolated from several species of the genus astragalus by high performance liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry. seven astragalosides in radix astragali and their commercial pharmaceutical preparations were analyzed using the developed method. the extracted ion current chromatograms were obtained from the total ion current chro ... | 2006 | 17017014 |
| solvent effect in 1h nmr spectra of 3'-hydroxy-4'-methoxy isoflavonoids from astragalus membranaceus var. mongholicus. | four 3'-hydroxy-4'-methoxy-isoflavonoids: calycosin-7-o-beta-d-glucopyranoside (1), calycosin (2), pratensein-7-o-beta-d-glucopyranoside (3), and pratensein (4) were isolated from astragalus membranaceus var. mongholicus, among which compound 4 was obtained from this plant for the first time. the solvent effect obscuring (1)h signal patterns of b ring of compounds 1-4 was reported to avoid mis-assignments. previously reported nmr data of compounds 1 and 2 were corrected based on 1d and 2d nmr ex ... | 2006 | 16602082 |
| [standard operating procedure for astragalus membranaceus]. | in order to ensure the superior quality and safety of the raw materials of the chinese herbal medicine, a standard operating procedure for astragalus was established on the base of the gap of the chinese herbal medicine as well as practice investigation and experiments. this standard operating procedure provides the technical requirements for astragalus's growing, field management, controlling of the diseases and pests, harvesting, processing, packing, storing, transporting and quality monitorin ... | 2006 | 16572994 |
| differential effects of isoflavones, from astragalus membranaceus and pueraria thomsonii, on the activation of pparalpha, ppargamma, and adipocyte differentiation in vitro. | compounds that target the peroxisome proliferator-activated receptors pparalpha and ppargamma are used to correct dyslipidemia and to restore glycemic balance, respectively. because the majority of diabetic patients suffer from atherogenic lipid abnormalities, in addition to insulin resistance, ligands are required that can activate both pparalpha and ppargamma. in this study, we used chimeric pparalpha/gamma reporter-gene bioassays to screen herbal extracts with purported antidiabetic propertie ... | 2006 | 16549448 |
| treatment of idiopathic membranous nephropathy with the herb astragalus membranaceus. | a 77-year-old woman with nephrotic syndrome secondary to idiopathic membranous nephropathy was treated with angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, cyclosporine a, and mycophenolate mofetil, without response. after more than 2 years of unremitting nephrosis, she began therapy with the herb astragalus membranaceus, used by traditional chinese physicians to treat various immune disorders, including glomerulonephritis. after institution of astragalus at a dose of 15 ... | 2007 | 18037104 |
| the effect of echinacea purpurea, astragalus membranaceus and glycyrrhiza glabra on cd25 expression in humans: a pilot study. | this phase 0, double-blind, repeated within subject, randomized pilot study examined cd25 expression on t cells after ingestion of three commonly used herbs: echinacea purpurea, astragalus membranaceus and glycyrrhiza glabra, administered singly and in combination. cd25 expression on t cells was significantly increased for subjects ingesting echinacea at 24 h with notable increases in activation from astragalus and glycyrrhiza. cd25 expression remains elevated with daily use of echinacea for at ... | 2007 | 17661330 |
| simultaneous characterization of isoflavonoids and astragalosides in two astragalus species by high-performance liquid chromatography coupled with atmospheric pressure chemical ionization tandem mass spectrometry. | a method was developed for the simultaneous identification of astragalosides (ags) and isoflavonoids (ifs) in the roots of astragalus membranaceus and astragalus mongholicus by hplc coupled with atmospheric pressure chemical ionization ms/ms (hplc-apci-ms/ms). diagnostic fragment ions of ags and different group of ifs were obtained with one ag and eight if standards analyzed by cid-ms, which were adopted as characteristic ms/ms fingerprints for further identification of these compounds in the tw ... | 2007 | 17657828 |
| [study on accumulation of dry matter and aborption of n, p and k of astragalus membranaceus]. | to study astragalus membranaceus absorption characteristic of nitrogen, phosphorus and potassium at different growth stages. | 2007 | 17639975 |
| a new isoflavone glucoside from astragalus membranaceus var. mongholicus. | a new isoflavone glucoside (1) was isolated from the roots of astragalus membranaceus var. mongholicus. its structure was elucidated by spectroscopic methods. | 2007 | 17600636 |
| preparative isolation of cyclolanostane-type saponins from astragalus membranaceus bge. var. mongholicus (bge.) hsiao by tlc-ms/ms guided high-speed counter-current chromatography. | two cyclolanostane-type saponins, astragalosides i and ii, were first identified by tlc-ms/ms in the ethyl acetate extract of the roots of astragalus membranaceus bge var. mongholicus (bge.) hsiao without chemical reference substances. they were then isolated by high-speed counter-current chromatography with a two-step two-phase solvent system of ethyl acetate-2-propanol-water (5:1:5, 50:1:50, v/v/v). the quantities of astragalosides i and ii isolated from 1 g of the crude extract were 30.2 mg a ... | 2007 | 17313153 |
| accumulation of calycosin and its 7-o-beta-d-glucoside and related gene expression in seedlings of astragalus membranaceus bge. var. mongholicus (bge.) hsiao induced by low temperature stress. | the changes in calycosin and calycosin-7-o-beta-d-glucoside content as well as the expression of genes involved in their biosynthesis were monitored in roots, stems and leaves of astragalus membranaceus bge. var. mongholicus (bge.) hsiao seedlings during 10 days of low temperature treatment. the concentrations of calycosin and its 7-o-beta-d-glucoside in the different tissues were analyzed using high-performance liquid chromatography. higher glycoside contents were observed at 2 degrees c than t ... | 2007 | 17253088 |
| effects of astragalus polysaccharides and astragalosides on the phagocytosis of mycobacterium tuberculosis by macrophages. | the herb astragalus membranaceus is used in traditional chinese medicine to boost immunity. this study investigated the effects of astragalus polysaccharides (aps) and astragalosides (as) on the phagocytosis of mycobacterium tuberculosis by macrophages. peritoneal macrophages were obtained by peritoneal lavage from mice stimulated by starch gravy culture medium and cultured with m. tuberculosis and varying concentrations of aps and as. phagocytotic activity was measured using a real-time polymer ... | 2007 | 17408058 |
| mechanisms by which astragalus membranaceus injection regulates hematopoiesis in myelosuppressed mice. | the aim of this study was to investigate the mechanism underlying the effects of astragalus membranaceus injection (ami) on myelopoiesis in myelosuppressed mice. at 72 h after cyclophosphamide injection (250 mg/kg), the mice were administered ami (500 mg/kg) intraperitoneally for 6 consecutive days or an equivalent volume of saline as a control. murine colony-forming unit-fibroblast (cfu-f) formation, production of il-6 and gm-csf by bone marrow stromal cells (bmsc), and bcl-2 protein and mrna e ... | 2007 | 17421056 |
| [astragalus membranaceus promote expression of insulin-like growth factor 1 in rat model of olivo-cerebellar degeneration]. | to observe the effect of astragalus membranaceus (am) on insulin-like growth factor 1 (igf-1) expression in a rat model of olivo-cerebellar degeneration and assess the neuroprotective actions of am meanwhile. | 2007 | 17432149 |
| mechanisms underlying vasorelaxant action of astragaloside iv in isolated rat aortic rings. | 1. astragaloside iv is a component from the widely used traditional chinese herb astragalus membranaceus and its effect on rat aortic ring contraction and relaxation were investigated. 2. the aorta from male sprague-dawley rats was isolated in an organ bath and ring tension was recorded with or without endothelium. cumulative effects of astragaloside iv on vessel contraction and relaxation were observed in the presence of various antagonists related to vessel activity. 3. astragaloside iv showed ... | 2007 | 17439405 |
| effect of astragaloside on cardiomyocyte apoptosis in murine coxsackievirus b3 myocarditis. | astragaloside is the major component of astragalus membranaceus, one of the chinese medical herbs, and has several pharmacological actions on cardiovascular system, including positive inotropic, anti-arrhythmia and anti-oxidant activities. we have investigated the effect of astragaloside on cardiomyocyte apoptosis and expression of apoptosis-associated genes in mice with coxsackievirus b(3) (cvb(3))-induced myocarditis, the former of which has been detected by terminal deoxynucleotidyltransferas ... | 2007 | 17454311 |
| modification of alterations in cardiac function and sarcoplasmic reticulum by astragaloside iv in myocardial injury in vivo. | astragaloside iv, the primary pure saponin isolated from astragalus membranaceus has been found to have potent cardioprotective effects. in this study, we aim to investigate if the beneficial effects of astragaloside iv on cardiac function are associated with improvement in sarcoplasmic reticulum ca(2+)-pump function in myocardial injury in vivo. myocardial injury in rats was induced by subcutaneous injection of a high dose of isoproterenol, and the therapeutic effect of astragaloside iv was obs ... | 2007 | 17509559 |
| [study on the role of polysaccharide and flavone in chinese herbs in protecting dna with fluorescence probe]. | the aim of the present work is to study the role of polyaccharide and flavone compounds of flos lonicerae, ganoderma lucidum etc. in protecting dna with eb as a probe to determine the fluorescence integration intensity of dna and eb mixture. d is defined as the interaction constant between different extracts from traditional chinese herbs and dna. the bigger the d, the stronger the interaction of drugs and dna. according to the definition of d, the impact of polysaccharide and flavone compounds ... | 2007 | 17514973 |
| effects and mechanisms of extract from paeonia lactiflora and astragalus membranaceus on liver fibrosis induced by carbon tetrachloride in rats. | paeonia lactiflora and astragalus membranaceus are two popular traditional chinese medicines, commonly used in chinese herb prescription to treat liver disease. the extract prepared from the roots of paeonia lactiflora and astragalus membranaceus (pae) demonstrated more excellent hepato-protective activity than the single herbs used individually as indicated in our preliminary studies. the present study was carried out to investigate the effects of pae on liver fibrosis in rats induced by carbon ... | 2007 | 17574357 |
| in vitro and in vivo immunomodulating and immunorestorative effects of astragalus membranaceus. | astragalus membranaceus is a common traditional chinese medicinal plant widely used as a tonic to enhance the body's natural defense mechanisms. in this study, bioactive fractions were isolated from the roots of astragalus membranaceus. one of these fractions, designated as ai, was found to be the most potent with respect to its mitogenicity on murine splenocytes. effects of ai on both specific and nonspecific immunity in mouse models were examined. results showed that ai could exhibit mitogenic ... | 2007 | 17611061 |
| a combination of chinese herbs, astragalus membranaceus var. mongholicus and angelica sinensis, enhanced nitric oxide production in obstructed rat kidney. | the persistent renal hemodynamic maladjustment caused by imbalances between vasoactivators predisposes the kidney to tubulointerstitial injury and ultimate interstitial fibrosis. the decoction (a&a) of a combination of roots of two chinese herbs, astragalus membranaceus var. mongholicus and angelica sinensis, has shown antifibrotic effects in rats with chronic kidney diseases and improvement of renal blood flow in rats with acute ischemic renal injury. in the present study, we investigated the e ... | 2007 | 17627898 |
| [integrated treatment of traditional chinese medicine and western medicine for early- and intermediate-stage diabetic nephropathy]. | to study the therapeutic effect of traditional chinese herbal medicinal preparation tangshenqing (tsq) combined with alprostadil in the treatment of early- and intermediate-stage diabetic nephropathy (dn). | 2007 | 17666348 |
| oral administration of astragalus membranaceus inhibits the development of dnfb-induced dermatitis in nc/nga mice. | epicutaneously administered chemical antigens like 2,4-dinitrofluorobenzene (dnfb), evoke an atopic dermatitis (ad)-like dermatitis reaction in nc/nga mice under specific pathogen free (spf) conditions. astragalus membranaceus (am), is a popular herbal medicine used to treat allergic diseases in east asia. in the present study, we examined whether am suppress ad-like skin lesions in nc/nga mice treated with dnfb under spf conditions. oral administration of am to dnfb-treated nc/nga mice was foun ... | 2007 | 17666805 |
| merit of astragalus polysaccharide in the improvement of early diabetic nephropathy with an effect on mrna expressions of nf-kappab and ikappab in renal cortex of streptozotoxin-induced diabetic rats. | diabetic nephropathy (dn) is the leading cause of the end-stage failure of kidney, but the efficacy of currently available strategies for the prevention of dn remains poor. an activation of the transcription factor, nuclear factor-kappab (nf-kappab), has been suggested to be a key step in the pathogenesis of dn. in the present study, we investigated the effect of astragalus polysaccharide (aps), an aqueous extract from the astragalus membranaceus roots, on gene expressions of nf-kappab and an in ... | 2007 | 17900838 |
| combined effects of fangchinoline from stephania tetrandra radix and formononetin and calycosin from astragalus membranaceus radix on hyperglycemia and hypoinsulinemia in streptozotocin-diabetic mice. | the anti-hyperglycemic action of stephania tetrandra radix (stephania) is potentiated by astragalus membranaceus bunge radix (astragali) in streptozotocin (stz)-diabetic ddy mice (tsutsumi et al., biol. pharm. bull., 26, 313 (2003)). fangchinoline (0.3-3 mg/kg), a main constituent of stephania, decreased the high level of blood glucose and increased the low level of blood insulin in stz-diabetic mice. here, we investigated the combined effects of fangchinoline with isoflavone or isoflavonoid com ... | 2007 | 17978479 |
| subchronic toxicity studies of radix astragali extract in rats and dogs. | radix astragali extract (rae) is obtained from astragalus membranaceus. it consists of astragalus polysaccharide and astragalus membranaceus saponins. in the study, we observed the subchronic toxicity of rae in sprague-dawley rats and beagle dogs to evaluate the safety dosage range in clinical application. these subjects were daily administered of rae by intra-peritoneum or vein for three consecutive months. general index were observed such as food-intake, behavior, body weight, hematological pa ... | 2007 | 17052876 |
| effects of astragalus membranaceus and its main components on the acute phase endothelial dysfunction induced by homocysteine. | this study was designed to investigate the effects of astragalus membranaceus (am) and its main components, astragalus saponin (asp), astragalus polysaccharide (aps) and aminobutyric acid (gaba), on homocysteine (hcy) induced acute impairment of vascular tone and to explore whether the antioxidant mechanism was involved in am protective effect. | 2007 | 17196887 |
| in vitro and in vivo anti-tumor effects of astragalus membranaceus. | astragalus membranaceus, a commonly used chinese medicinal plant, has been shown to be capable of restoring the impaired t cell functions in cancer patients. in this study, the in vitro and in vivo anti-tumor effects of a. membranaceus were investigated. five bioactive fractions were isolated from the root of a. membranaceus, the fraction designated as ai was found to be the most potent among the five fractions with respect to its mitogenicity on murine splenocytes. besides investigating the cyt ... | 2007 | 17223259 |
| dang-gui buxue tang protects against oxidant injury by enhancing cellular glutathione in h9c2 cells: role of glutathione synthesis and regeneration. | in order to investigate the biochemical mechanism of dang-gui buxue tang (dbt) involved in its cardioprotective action, the effects of dbt and related preparations on the cellular level of reduced glutathione (gsh) and on susceptibility to menadione-induced toxicity were examined in h9c2 cardiomyocytes. treatment with herbal extract prepared from the fresh root of astragalus membranaceus (ram) or angelica sinensis (ras) alone and their combinations (d1:1-d10:1) in varying ratios of ram to ras (1 ... | 2007 | 17325989 |
| [study on composing mechanism by effect of disassembled compositions of yiqi huoxue decoction on platelet aggregation of health adults]. | to investigate and explain the composing mechanism by observing enhancement property of disassembled compositions of yiqi huoxue decoction (yqhxd) on platelet aggregation of health adults. | 2007 | 18309677 |
| preparation and suppressive effect of astragalus polysaccharide in glomerulonephritis rats. | astragalus membranaceus (am) has been widely used for treating kidney diseases in traditional chinese medicine. in this study, the astragalus polysaccharide (aps), the main active ingredient was isolated and purified from the rhizomes of am, which consisted of d-glucopyranose and had the molecular weight of 3.6x10(4) da. the effect of aps on glomerulonephritis rats induced by cationic bovine serum albumin(c-bsa) was evaluated by flow cytometry using nuclear transcription factor-kappab (nf-kappab ... | 2007 | 17161813 |
| [the protective effect of astragalus membranaceus extraction on cryopreserved primary-cultured human fetal hepatocytes]. | to observe the influence of astragalus membranaceus extraction (ae) on the primary-cultured human fetal hepatocytes stored in liquid nitrogen and explore a new method for the cryopreservation of human hepatocytes with improved function. | 2007 | 18422189 |
| inhibitory effects of astragaloside iv on ovalbumin-induced chronic experimental asthma. | astragaloside iv, a new cycloartane-type triterpene glycoside extract of astragalus membranaceus bunge, has been identified for its potent immunoregulatory, antiinflammatory, and antifibrotic actions. here we investigated whether astragaloside iv could suppress the progression of airway inflammation, airway hyperresponsiveness, and airway remodeling in a murine model of chronic asthma. balb/c mice sensitized to ovalbumin (ova) were chronically challenged with aerosolized ova for 8 weeks. astraga ... | 2008 | 18641694 |
| astragaloside iv improves high glucose-induced podocyte adhesion dysfunction via alpha3beta1 integrin upregulation and integrin-linked kinase inhibition. | impaired podocyte adhesion to glomerular basement membrane (gbm) may contribute to podocyte detachment from gbm, which represents a novel early mechanism leading to diabetic nephropathy (dn). here, we examined the effects of astragaloside iv (as-iv), a saponin purified from astragalus membranaceus (fisch) bge, on high glucose-induced cell adhesion dysfunction in cultured mouse podocytes. cells were seeded into 96-well plates coated with basement membrane protein complex (bmc). the cells were inc ... | 2008 | 18652804 |
| immune modulation of macrophage pro-inflammatory response by goldenseal and astragalus extracts. | goldenseal (hydrastis canadenisis) is a native american medicinal plant used as an immune stimulant. astragalus (astragalus membranaceus) is a widely used herbal product in china, other asian countries, and the united states as an immune stimulant to be taken on first clinical signs of infection. in this study, the innate effects of goldenseal and astragalus on pro-inflammatory cytokines produced by cultured macrophages were examined using two different commercial preparations of goldenseal and ... | 2008 | 18800897 |
| protective effect of extract from paeonia lactiflora and astragalus membranaceus against liver injury induced by bacillus calmette-guérin and lipopolysaccharide in mice. | paeonia lactiflora and astragalus membranaceus are two popular traditional chinese medicines, commonly used in chinese herb prescription to treat liver disease. the extract from the roots of p. lactiflora and a. membranaceus demonstrated better hepatoprotective activity than the herbs used individually as shown in our previous studies. the present study was carried out to investigate the effects of p. lactiflora and a. membranaceus extract on immunological liver injury in mice induced by bacillu ... | 2008 | 18816297 |
| mesorhizobium gobiense sp. nov. and mesorhizobium tarimense sp. nov., isolated from wild legumes growing in desert soils of xinjiang, china. | twenty-four mesorhizobium strains were isolated from desert soils in the xinjiang region of china and were characterized by a polyphasic approach. these strains grouped into three clusters in igs-rflp, sds-page analysis of whole-cell proteins and box-pcr analysis, corresponding to genomic species v, vi and vii as found in a previous study. the results were supported by sequencing analyses of rrs, igs, atpd and reca genes. genospecies vii was most related to mesorhizobium septentrionale, while ge ... | 2008 | 18984702 |
| [professor ling changquan's experience in treating primary liver cancer: an analysis of herbal medication]. | on the basis of outpatients' medical records concerning primary liver cancer (plc), data of 552 patients (with 2020 effective prescriptions) from the outpatient department of changhai hospital treated by professor ling changquan were collected. the nature, flavor and meridian distribution of the herbs used in the prescriptions were summarized by frequency method, and the features of the herbs used according to syndrome differentiation were analyzed by logistic regression. the couple herbs used w ... | 2008 | 19063833 |
| astragaloside iv improved intracellular calcium handling in hypoxia-reoxygenated cardiomyocytes via the sarcoplasmic reticulum ca-atpase. | although astragaloside iv, a saponin isolated from astragalus membranaceus, has been shown to protect the myocardium against ischemia/reperfusion injury, its effect on the status of sarcoplasmic reticulum (sr) ca2+ transport in the injured myocardium remains largely unknown. in this study, we investigated whether in cultured cardiomyocytes subjected to hypoxia and reoxygenation (h/r) administration of astragaloside iv during h/r attenuates the myocardial cell injury and prevents changes in ca2+ ... | 2008 | 18349554 |
| [regulatory effect of astragalus membranaceus on the immune disorder in rats with iga nephropathy]. | to study the regulattory effect of astragalus membranaceus on immune disturbance of the rats with iga nephropathy. | 2008 | 18353241 |
| identification of major constituents in the traditional chinese medicine "qi-shen-yi-qi" dropping pill by high-performance liquid chromatography coupled with diode array detection-electrospray ionization tandem mass spectrometry. | an hplc-dad-esi-ms(n) method was developed for simultaneous analysis of major chemical constituents in "qi-shen-yi-qi" dropping pill, a traditional chinese medicine (tcm) widely used for treating cardiovascular diseases. the chromatographic separation was performed on an intertsil ods-3 c(18) column (4.6 mm x 250 mm, 5 microm), whilst water with 0.05% acetic acid and acetonitrile were used as mobile phase. on the basis of the characteristic uv absorption profile, the information of molecular wei ... | 2008 | 18387767 |
| [effects of astragalus membranaceus on atrial dynamics and anp secretion]. | to define the effects of astragalus membranaceus on the atrial dynamics and anp secretion in the perfused beating rabbit atria. | 2008 | 19166013 |
| degradation of phenanthrene and pyrene in rhizosphere of grasses and legumes. | phytoremediation is an emerging technology for the remediation of organic soil pollutants such as phenanthrene and pyrene (polycyclic aromatic hydrocarbons, pahs). the pah degradation ability of four native korean plant species (panicum bisulcatum, echinogalus crus-galli, astragalus membranaceus, and aeschynomene indica) was compared in the greenhouse. during the 80-day experiment, soil samples were collected and analyzed periodically to determine the residual pah content and microbial activity. ... | 2008 | 17959304 |
| astragali radix elicits anti-inflammation via activation of mkp-1, concomitant with attenuation of p38 and erk. | although astragali radix (astragalus, ar), the root of astragalus membranaceus (fisch) bunge, is widely used in oriental medicine for tonifying the immune response and improving circulation, the underlying mechanism(s) by which these effects are induced remains unclear. here, we report that ar displays anti-inflammatory effects in zymosan air-pouch mice by reducing the expression of inos, cox-2, il-6, il-1beta and tnf-alpha and by decreasing the production of nitric oxide (no). in a similar mann ... | 2008 | 17996413 |
| treatment of viral myocarditis caused by coxsackievirus b. | the treatment options for viral myocarditis caused by coxsackievirus b are summarized. | 2008 | 18192257 |
| polysaccharides from astragalus membranaceus promote phagocytosis and superoxide anion (o2-) production by coelomocytes from sea cucumber apostichopus japonicus in vitro. | the potential immunostimulatory effects of astralagus membranaceus polysaccharides (aps) on sea cucumber, apostichopus japonicus (selenka), were investigated in vitro. phagocytosis and superoxide anion (o(2)(-)) production by phagocytic amoebocytes (pa) from a. japonicus coelomic fluid were measured during incubation at 18 degrees c, 22 degrees c, or 25 degrees c with aps at 0, 10, 20, or 40 microg ml(-1) (n=3). phagocytic activity against yeast cells was quantified by direct visualization, and ... | 2008 | 18221918 |
| astragalus membranaceus prevents airway hyperreactivity in mice related to th2 response inhibition. | asthma is recognized as a common pulmonary disease throughout the world. to date, there has been a growing interest in herbal products in traditional chinese medicine, which is considered to be effective to treat asthma. a chinese herb astragalus membranaceus (am) was found useful in treating allergic diseases. the purpose of this study is to determine whether this herbal injection could suppress allergic-induced ahr and mucus hypersecretion in allergic mice. | 2008 | 18226482 |
| [changes of peripheral blood dendritic cell functions in children with henoch-schonlein purpura and in vitro effect of astragalus membranaceus]. | 2008 | 19099866 | |
| [therapeutic application and prospect of astragalus membranaceus and angelica sinensis in treating renal microvascular lesions]. | it has been known that the renal microvasular lesions could aggravate the progress of glomerular sclerosis and tubulo-interstitial fibrosis in chronic kidney diseases. modern pharmacological studies indicated that the two traditional chinese herbs, astragalus membranaceus and angelica sinensis, could improve micorvascular lesions through multiple mechanisms, including increasing local renal blood flow to lessen the hypoxic renal injury, promoting the recovery of renal blood flow and glomerular f ... | 2008 | 19065906 |
| [effects of nitrogen, phosphorus and potassium application on growth and active ingredient of astragalus membranaceus]. | to study the effects of fertilizers with the different proportional of nitrogen, phosphorus and potassium on growth and active ingredient of astragalus membranaceus. | 2008 | 19007001 |
| [determination of mineral elements in different part of astragalus membranaceus(fisch.) by faas]. | having digested the root and shoot of astragalus membranaceus (fisch.) with the mixture of nitric acid and perchloride acid (4 : 1) under the condition of the bolling point and the normal pressure, the contents of the five mineral elements necessary to humanity, potassium, copper, zinc, iron and manganese in root and shoot of astragalus membranaceus (fisch.) were determined by flame atomic absorption spectroscopy (faas), and the results were analyzed in statistics. the correlative coefficient of ... | 2008 | 18720826 |
| [study on difference of biological characteristics and resistance to powdery mildew of different astragalus populations]. | to study difference among populations which belong to astragalus membranaceus and a. membranaceus var. mongholicus on morphology, habit, characteristics of physiology and resistance to powdery mildew, and classify them in order to provide theoretical basis for breeding and improving varieties. | 2008 | 18652339 |
| phenylalanine ammonia lyase functions as a switch directly controlling the accumulation of calycosin and calycosin-7-o-beta-d-glucoside in astragalus membranaceus var. mongholicus plants. | previously it had been shown that calycosin and calycosin-7-o-beta-d-glucoside (cgs) accumulate in whole plants, mainly in leaves, of astragalus membranaceus bge. var. mongholicus (bge.) hsiao (a. mongholicus) plants in response to low temperature. in this work, it was demonstrated that the influences of different conditions on cgs biosynthesis, by examining the changes in cgs content, as well as the expression of related genes, including phenylalanine ammonia lyase (pal1), cinnamic acid 4-hydro ... | 2008 | 18583351 |
| a randomized, double-blind, placebo-controlled study of the effect of a chinese herbal medicine preparation (dang gui buxue tang) on menopausal symptoms in hong kong chinese women. | many complementary or alternative medicines are being used for the treatment of menopausal symptoms but most have not been properly tested for efficacy or for safety. this study examined the effect of a chinese herbal preparation (dang gui buxue tang) on menopausal symptoms in hong kong chinese women. | 2008 | 18568789 |
| effects of traditional chinese medicine on immune responses in abalone, haliotis discus hannai ino. | a traditional chinese medicine (tcm) preparation was formulated from orange peel (pericarpium citri reticulatae), hawthorn (crataegus pinnatifida), astragalus (astragalus membranaceus (fisch.) bunge), pilose asiabell root (radix codonopsis), indigowoad root (radix isatidis), taraxacum (herba taraxaci) and malt (fructus hordei germinatus) at a weight ratio of 1:1:1.5:1.5:1.5:1.5:2. a feeding experiment was conducted to determine the effects of tcm on innate immunity of abalone, haliotis discus ha ... | 2008 | 18378466 |
| micellar electrokinetic chromatography for the quantitative analysis of flavonoids in the radix of astragalus membranaceus var. mongholicus. | the separation and determination of eight flavonoids in the radix of astragalus membranaceus (fisch.) bge var. mongholicus (bge.) hsiao was achieved by using micellar electrokinetic chromatography (mekc) with a diode array detector (dad). the influence of background electrolyte (bge) concentrations and ph, surfactant concentrations, organic solvents, temperature, and voltage on the separate procedure was systematically investigated. the optimal resolution was obtained with a micellar phase consi ... | 2008 | 18203052 |
| two new cycloartane saponins from the roots of astragalus membranaceus. | two new cycloartane-type triterpenoid saponins were isolated from the roots of astragalus membranaceus (fisch.) bge. (leguminosae) cultivated in kangwon province, korea. these saponins were named astramembranosides a and b and were established to be cycloastragenol 6,25-di-o-beta-d-glucopyranoside (astramembranoside a) and cyclocanthogenin 3-o-beta-d-glucopyranosyl(1-->2)-beta-d-xylopyranoside (astramembranoside b) on the basis of chemical and spectral evidence. in addition, 12 known saponins we ... | 2008 | 18175987 |
| synergistic antioxidant activities of eight traditional chinese herb pairs. | many chinese therapeutic herbs that are traditionally used in combination demonstrate significantly better pharmacological effects when used in the combination than when used alone. however, the pharmacological mechanism for this synergism is still not well understood. in the present study, the antioxidant activities of six herbs ((paeonia lactiflora (pl), atractylodes macrocephala (ama), angelica sinensis (as), astragalus membranaceus (ame), glycyrrhiza uralensis (gu) and rheum officinale (ro)) ... | 2009 | 19483308 |
| [study on genetic relationship of astragalus membranaceus var mongholicus in different producing area using srap]. | to study the genetic relationship of astragalus membranaceus var. mongholicus in different producing area and provide theoretical basis for the evaluation of astragalus germplasm resources. | 2009 | 19459294 |
| myelophil, an extract mix of astragali radix and salviae radix, ameliorates chronic fatigue: a randomised, double-blind, controlled pilot study. | to investigate the anti-fatigue effects of myelophil, an extract of a mix of astragali radix and salviae radix, which has been used to treat patients with chronic fatigue. | 2009 | 19398067 |
| [study on extraction and purification of polysaccharides from astragalus membranaceus]. | to optimize the extraction and purification procedure for polysaccharides from astragalus membranaceus. | 2009 | 20218299 |
| [analysis and identification of huangqi and its counterfeit ciguogancao by two dimensional corrlation infrared spectroscopy]. | standard huangqi (astragalus membranaceus (fisch) bge. var. monghlicus (bge.) hsiao) and its counterfeit ciguogancao (glychrrhiza pallidiflora maxim.) can be discriminated and identified by using multi-steps infrared maro--fingerprint method. in the 1d-ir spectra, the peak intensity at 1 737 cm(-1) for ciguogancao, which is the stretching vibration peak of c==o, is much stronger than that of huangqi. it's proved that the organic ester compounds in ciguogancao are much more than huangqi. in the s ... | 2009 | 19950637 |
| [a taxonomic study on the original plant of radix astragali]. | there are dispute about the status of taxonomy among astragalus membranaceus (fisch.) bge, a. membranaceus (fisch.) bge. var. mongholicus (bge.) hsiao. and a. pallidipurpureus stat. nov. the varieties and taxa of the complex are still in need of revision. with molecular biology study used trnh-psba intergenic region, the taxonomic revision of radix astragali has been made. a. pallidipurpureus stat. nov is suggested as a new species. | 2009 | 21351481 |
| astragalus saponins induce apoptosis via an erk-independent nf-kappab signaling pathway in the human hepatocellular hepg2 cell line. | astragalus membranaceus has been used to ameliorate the side effects of anti-neoplastic drugs. we recently reported that total astragalus saponins (ast) possess anti-tumor properties in human colon cancer cells and tumor xenografts. nevertheless, the precise mechanism of action has not been fully elucidated. the present study aimed to unveil the anti-carcinogenic potential of ast in hepg2 human hepatocellular carcinoma (hcc) cells and to clarify the signaling pathway. we demonstrated here that a ... | 2009 | 19148542 |
| astragalus membranaceus prevents daunorubicin-induced apoptosis of cultured neonatal cardiomyocytes: role of free radical effect of astragalus membranaceus on daunorubicin cardiotoxicity. | anthracyclines are antitumor antibiotics with significant activity against solid and hematologic malignancies. one problem preventing more widespread use has been the development of cardiotoxicity. to determine whether antioxidant agents can reduce the cardiotoxicity of anthracyclines, a herb astragalus membranaceus was introduced, which has been widely used for the treatment of cardiovascular diseases in china and was confirmed to be an effective antioxidant agent recently. pre-treatment with a ... | 2009 | 19172580 |
| inhibitory effects of calycosin isolated from the root of astragalus membranaceus on melanin biosynthesis. | tyrosinase is a key enzyme for melanin biosynthesis, and hyperpigmentation disorders are associated with abnormal accumulation of melanin pigments, which can be reduced by treatment with depigmenting agents. a methanol extract of astragalus membranaceus showed inhibitory activity against mushroom tyrosinase. the active compound was purified from the methanol extract of a. membranaceus and, following several chromatographic methods, was identified as calycosin via spectroscopic analysis. the resu ... | 2009 | 19182387 |
| hypoglycemic effect of polysaccharide enriched extract of astragalus membranaceus in diet induced insulin resistant c57bl/6j mice and its potential mechanism. | our previous studies found that astragalus polysaccharide (aps) exerts insulin-sensitizing and hypoglycemic activities in type 2 diabetic (t2dm) rats. the present study was designed to further confirm the hypoglycemic effect of aps and to investigate its possible mechanism underlying the improvement of insulin resistance in vivo and in vitro. diet-induced insulin resistant c57bl/6j mice treated with or without aps (orally, 700 mg/kg/d) for 8 weeks were analyzed and compared. simultaneously, an i ... | 2009 | 19201177 |
| effect of astragaloside iv on the embryo-fetal development of sprague-dawley rats and new zealand white rabbits. | astragaloside iv, a natural product purified from the chinese medicinal herb astragalus membranaceus (fisch) bge, is now being developed as a cardioprotective agent for treating cardiovascular diseases. in the present study developmental toxicity of astragaloside iv in sprague-dawley rats and new zealand white rabbits was evaluated by intravenously administering astragaloside iv daily to rats at 0.25, 0.5 and 1.0 mg kg(-1) on gestation days 6-15, and to rabbits at 0.5, 1.0 and 2.0 mg kg(-1) dail ... | 2009 | 19367606 |
| astragaloside iv attenuates cerebral ischemia-reperfusion-induced increase in permeability of the blood-brain barrier in rats. | astragalus membranaceus is widely used to treat stroke and chronic debilitating diseases in china, but the mechanism has not been fully demonstrated to data. in the present study, we, using astragaloside iv, a purified extract from astragalus membranaceus, to a focal cerebral ischemia/reperfusion rat model, aimed to investigate the effect of astragaloside iv on the permeability of the blood-brain barrier since disruption of blood-brain barrier induced by ischemia/reperfusion leads to serious bra ... | 2009 | 19374856 |
| a novel anticancer effect of astragalus saponins: transcriptional activation of nsaid-activated gene. | astragalus membranaceus has been used to ameliorate the side effects of antineoplastic drugs because of its immunomodulating nature. we had recently demonstrated that total astragalus saponins (ast) possess anticarcinogenic and proapoptotic properties in human colon cancer cells and tumor xenograft. in this study, we identified nsaid-activated gene (nag-1) as a potential molecular target of ast. the growth-inhibitory and proapoptotic effects of ast were assessed in a panel of human cancer cell l ... | 2009 | 19384947 |
| neuroprotective effects of astragaloside iv in 6-hydroxydopamine-treated primary nigral cell culture. | parkinson's disease (pd) is caused by a progressive degeneration of dopaminergic neurons in the substantia nigra. oxidative stress and neural degeneration are suggested to be involved in the pathogenesis of parkinson's disease. in the present study, astragaloside iv (as-iv) extracted from the dried root of astragalus membranaceus, a well-known chinese medicine used for the treatment of neurodegenerative diseases, was investigated for its capacity to protect dopaminergic neurons in experimental p ... | 2009 | 19409437 |
| suppressive effects of swainsonine on c6 glioma cell in vitro and in vivo. | swainsonine, an extract from astragalus membranaceus, is known for its anti-cancer effects and could prevent metastases. in order to investigate the effects and mechanisms of swainsonine in c6 glioma cells, we carry out correlated experiments in vitro and in vivo. after treatment with swainsonine, the effective dose and ic(50) value of swainsonine in the c6 glioma cell were examined using the mtt assay. cell cycle distribution and apoptotic rates were analyzed using fcm and [ca(2+)](i) was measu ... | 2009 | 19427771 |
| protective effects of astragaloside iv on porcine-serum-induced hepatic fibrosis in rats and in vitro effects on hepatic stellate cells. | astragaloside iv is the primary pure saponin isolated from astragalus membranaceus, one of the valuable traditional medical herbs. antifibrotic activities of astragalus membranaceus have been extensively proved. | 2009 | 19429320 |
| astragalus mongholicus ameliorates renal fibrosis by modulating hgf and tgf-beta in rats with unilateral ureteral obstruction. | astragalus mongholicus (am) derived from the dry root of astragalus membranaceus bge. var. mongolicus (bge.) hsiao is a widely used traditional chinese medicine. the present study investigated the potential role of am on renal fibrosis on a rat model of unilateral ureteral obstruction (uuo). we divided 48 sprague-dawley rats randomly into 4 groups: sham-operated group (sham), untreated uuo group, am-treated (10 g/(kg x d)) uuo group, and losartan-treated (20 mg/(kg x d)) uuo group as positive co ... | 2009 | 19434765 |
| wound-healing activity of astragali radix in rats. | inhibition of inflammatory responses, acceleration of basal cell growth and balanced synthesis of the extracellular matrix (ecm) are important in the healing of open cutaneous wounds. to evaluate the wound-healing effects of astragali radix (ar) (the root of astragalus membranaceus [fisch.]), experimental open wounds were made on the dorsal side of rats under anesthesia. boiling water extracts of ar, soaked into a hydrophilic foam dressing, were topically applied to the wounds once a day for 11 ... | 2009 | 19455264 |
| cytotoxic activities of 9,11-dehydroergosterol peroxide and ergosterol peroxide from the fermentation mycelia of ganoderma lucidum cultivated in the medium containing leguminous plants on hep 3b cells. | the objective of this study was to investigate the cytotoxicity of the ethanolic extract of mycelia from ganoderma lucidum (emg) cultivated in a medium containing leguminous plants glycine max (l.) merr. and astragalus membranaceus on human hepatocellular carcinoma cells (hep 3b) and to isolate the active components from emg. the results indicated that emg induced cytotoxicity in a dose- and time-dependent manner, and the cells treated with emg for 24, 48, and 72 h had ic(50) values of 156.8, 89 ... | 2009 | 19492810 |
| the protective action of radix astragalus membranaceus against hapten-induced colitis through modulation of cytokines. | astragalus membranaceus is a medicinal herb with potential immunomodulatory property, which has been used in treating colitis-related diarrhea. in the present investigation, we aimed to further explore its anti-inflammatory activity by studying the immunoregulatory mechanism of astragalus root extract (am) through different routes of administration in hapten-induced colitis. 2,4-dinitrobenzene sulfonic acid (dnbs) was used to induce experimental colitis in sprague-dawley rats. results have indic ... | 2009 | 19539495 |
| saponin fraction from astragalus membranaceus roots protects mice against polymicrobial sepsis induced by cecal ligation and puncture by inhibiting inflammation and upregulating protein c pathway. | sepsis remains the leading cause of death in intensive care units. uncontrolled systemic inflammation and an impaired protein c pathway are two important contributors to sepsis pathophysiology. based on the beneficial effects of the saponin fraction from astragalus membranaceus roots (sam) against inflammation, liver dysfunction, and endothelium injury, we investigated the potential protective roles and underlying mechanisms of sam on polymicrobial sepsis induced by cecal ligation and puncture ( ... | 2009 | 19548065 |
| a combination of chinese herbs, astragalus membranaceus var. mongholicus and angelica sinensis, improved renal microvascular insufficiency in 5/6 nephrectomized rats. | chronic renal ischemia and hypoxia in the tubulointerstitium are involved in the mechanisms of progressive chronic kidney disease. previous studies showed that the decoction of a combination of two chinese herbs, astragalus membmnaceus var. mongholicus and angelica sinensis (a & a) has antifibrotic effects through multiple pathways in different animal models. in this study, remnant kidney model was employed to investigate whether a & a affect the expression of vegf, the density of the renal micr ... | 2009 | 19563735 |
| astragalus improved cardiac function of adriamycin-injured rat hearts by upregulation of serca2a expression. | the traditional chinese medical herb astragalus, the dried root of astragalus membranaceus (fisch.) bge., has been widely applied to treat patients with cardiovascular disease in china and has profound cardioprotective effects. this study investigated the effect of astragalus on hemodynamic changes in adriamycin (adr)-injured rat hearts and its underlying molecular mechanism. sprague-dawley rats were divided into four groups: control, adr only, adr + low dose of astragalus and adr + high dose of ... | 2009 | 19606512 |
| astragalosides isolated from the root of astragalus radix inhibit the formation of advanced glycation end products. | because advanced glycation end product (age) inhibitors such as pyridoxamine significantly inhibit the development of retinopathy and neuropathy in the streptozotocin-induced diabetic rat, treatment with age inhibitors is believed to be a potential strategy for the prevention of lifestyle-related diseases such as diabetic complications. a crude extract of astragali radix (ar; roots of astragalus membranaceus ) inhibits the formation of n(epsilon)-(carboxymethyl)lysine (cml) and pentosidine durin ... | 2009 | 19681610 |
| [effects of astragalus membranaceus injection on tnf-alpha-induced release of inflammatory factors from huvecs and the molecular mechanisms]. | to investigate the protective effect of astragalus membranaceus injection on human umbilical vein endothelial cells (huvecs) against tumor necrosis factor alpha (tnf-alpha). | 2009 | 19726342 |
| systematic review of the renal protective effect of astragalus membranaceus (root) on diabetic nephropathy in animal models. | diabetic nephropathy (dn) has long been recognized as the leading cause of end-stage renal disease. recent experimental studies have shown that astragalus membranaceus (am) (root) has an inhibitory effect on the oxidative stress that characterizes early dn. this systematic review assesses the efficacy and safety of am (root), used as a single herb, in slowing the progression of dn in diabetic rat models. | 2009 | 19735713 |
| enhancement of non-specific immune response in sea cucumber (apostichopus japonicus) by astragalus membranaceus and its polysaccharides. | in this study, the immunostimulatory effect of oral administration of different preparations (conventional fine powder [cp] and superfine powder [sp]) of astragalus membranaceus root or its polysaccharides (aps) in sea cucumber (apostichopus japonicus) was investigated. sea cucumbers with an average initial weight of 49.3 +/- 5.65 g were fed with a diet containing 3% cp or sp or 0.3% aps over a period of 60 days. the non-specific humoral (phenoloxidase, lysozyme and agglutination titer) and cell ... | 2009 | 19748588 |
| astragalus membranaceus flavonoids (amf) ameliorate chronic fatigue syndrome induced by food intake restriction plus forced swimming. | alteration of immune function may be associated with chronic fatigue syndrome (cfs) and this study reveals the immunoregulatory effect of astragalus membranaceus flavonoids (amf). | 2009 | 19103273 |
| the production of nitric oxide and prostaglandin e2 in peritoneal macrophages is inhibited by andrographis paniculata, angelica sinensis and morus alba ethyl acetate fractions. | traditional chinese medicine herbs (tcmhs) are used in medicines as well as in daily dietary supplements in asia. in this study, we employed pnf-kappab-luc or pifn-gamma-luc and balb/c mice peritoneal macrophages or splenocytes to investigate both the immune and inflammatory effects of six selected plant species. | 2009 | 19111919 |
| in vivo and in vitro antiviral activities of calycosin-7-o-beta-d-glucopyranoside against coxsackie virus b3. | calycosin-7-o-beta-d-glucopyranoside (ccgr) is the main isoflavonoid compound isolated from astragalus membranaceus var. mongholicu (bge.) hsiao, a chinese herb medicine traditionally used to treat viral myocarditis. in this study, its antiviral activities against coxsackie virus b3 (cvb3) causing myocarditis were investigated. in vitro assay showed that ccgr displayed a low cytotoxicity and effectively inhibited cvb3-mediated cytopathic effects on vero cells with an ic(50) value of 25 microg/ml ... | 2009 | 19122283 |
| the effects of astragalus membranaceus on repeated restraint stress-induced biochemical and behavioral responses. | astragalus membranaceus (am) is a useful korean herb that has been clinically prescribed for stress-related illness. the objective of the present study was to examine the anti-stress effects of am on repeated stress-induced alterations of anxiety, learning and memory in rats. restraint stress was administered for 14 days (2h/day) and am (400mg/kg) given by oral administration, in the am group, for the same period. starting on the eighth day, the rats were tested for spatial memory on the morris ... | 2009 | 19885016 |
| [effects of astragalus membranaceus on cytokine secretion of peripheral dendritic cells in children with henoch-schonlein purpura in the acute phase]. | to explore the effects of astragalus membranaceus (am) on the cytokines secretion of peripheral dendritic cells (dc), including interleukin-10, -12, and -18 (il-10, il-12 and il-18), in children with henoch-schonlein purpura (hsp) in the acute phase; and to study the immunological regulation mechanism of am. | 2009 | 19960975 |