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effect of polycations on growth and dissemination of the encephalomyocarditis virus in mice.pathogenicity of the encephalomyocarditis (emc) virus for adult mice was increased when polycations of diverse type were mixed with virus and inoculated by the subcutaneous or intraperitoneal routes. diethylaminoethyl (deae) dextran, hexadimethrine (polybrene), polymyxin b, polylysine, and calf thymus histone in various concentrations stimulated multiplication of virus in tissues at the injection site and enhanced entry of virus into the blood. the nonpathogenic r(+) variant of emc which grows l ...19674316242
distribution of cell receptors and simple sugar inhibitors during encephalomyocarditis virus-cell union.encephalomyocarditis (emc) virus was studied for ability to agglutinate erythrocytes of various species. human, rat, and guinea pig erythrocytes, as well as those from young rabbits, were readily agglutinated. cells from older rabbits absorbed virus poorly, and showed little agglutination. uptake of virus by rabbit brain also diminished with age. various mouse tissues absorbed virus about equally well. hemagglutination-inhibition studies demonstrated that a number of simple sugars, particularly ...19674318947
separation of plaque-type variants of encephalomyocarditis virus by chromatography on calcium phosphate.encephalomyocarditis (emc) virus (k-2 strain) was separated into two distinct peaks of optical density by chromatography on calcium phosphate, eluting at 0.17 and 0.31 m, respectively. the virus in these peaks could not be distinguished by infectivity (plaque-forming units), hemagglutinin activity, electron microscopic appearance, sedimentation coefficient, or base ratios. however, variants producing large plaques predominated in the first peak eluted, whereas variants producing small plaques we ...19674318950
interaction of encephalomyocarditis virus with ultraviolet-irradiated host cells.ultraviolet light (uv) impaired the capacity of l cells to support growth of encephalomyocarditis virus. the loss of capacity was partially restored by high multiplicity of infection (moi). this phenomenon was not due to an increased probability of an infectious virus particle reaching a site of replication undamaged by uv, since uv-inactivated virus at high moi induced restoration of the capacity to support multiplication of nonirradiated virus adsorbed at low moi. multiplicity reactivation of ...19674318958
effect of multiplicity of infection on the rate of protein synthesis in encephalomyocarditis virus-infected l cells. 19674382471
peculiarities of the antiviral action of dibenzylphosphinic acid. 19674382472
an interferon like substance induced by mannans. 19674382481
effect of a space cabin environment on viral infection. 19674383045
the temperature requirement for interferon production in cells stimulated by newcastle disease virus or microbial agents in vitro. 19674383884
production of interferon-like inhibitor in chickens after secondary induction by bacteria and virus. 19684385157
potentiation of the antiviral activity of interferon by histones. 19684386015
induction of interferon activity in mouse serum by phase i coxiella burneti antigen. 19684386026
inactivation of single- and double-stranded ribonucleic acid of encephalomyocarditis virus by ultraviolet light. 19684387327
a temporal and structural relationship between viral rna polymerase and nicotinamide adenine dinucleotide pyrophosphorylase in the cytoplasm of krebs-2 ascites cells infected with encephalomyocarditis virus. 19684329661
synthesis of ribonucleic acid by mengovirus-induced rna polymerase in vitro: nature of products and of rnase-resistant intermediate. 19684329736
[oral immunization with non living microorganisms or their antigens. 8. comparing experiments to vaccination by inhalation and nasal, oral, and rectal route]. 19684317590
[on a case of encephalomyocarditis]. 19684313601
destruction of l cells by mengo virus: use of interferon to study the mechanism.interferon, when added to l cells, inhibited the synthesis of infectious mengo viral ribonucleic acid, hemagglutinins, and infectious virus by 85 to 95%. serum-blocking antigens were also reduced by the action of interferon, but threefold excess amounts of these antigens accumulated in interferon-treated cultures above the amounts expected for the quantity of infectious virus that was produced in these cultures. radioautographic analysis showed that 28 to 36% of the cells of an interferon-treate ...19684301505
evidence of an infective component sensitive to ribonuclease in the brain homogenate fo mice inoculated with mm virus. 19684301715
the antiviral activity of 3,4-dihydro-1-isoquinolineacetamide hydrochloride in vitro, in ovo, and in small laboratory animals. 19684301999
replication of mengovirus in hela cells preinfected with nonreplicating poliovirus.the replication of mengovirus in hela cells preinfected with poliovirus in the presence of 10(-3) m guanidine was investigated. although host cell protein synthesis is inhibited by the presence of nonreplicating poliovirus, it is found that mengovirus ribonucleic acid (rna) and protein synthesis proceed normally under the same conditions. furthermore, no effects on mengovirus growth by poliovirus can be detected either when mengo protein synthesis is interrupted by acti-dione or when its rna syn ...19684302186
survival of a picornavirus and its infectious ribonucleic acid after aerosolization. 19684302283
enhancement of mengovirus nucleic acid infectivity by putrescine. 19684300093
analysis of nearest neighbour base frequencies in the rna of a mammalian virus: encephalomyocarditis virus. 19684300110
[characterization of various representatives of the columbia-sk virus group with fluorescent antibodies. ii. adaptation of columbia-sk viruses to l cells]. 19684300583
ultraviolet inactivation of mm virus rna in terms of sodium chloride concentrations. 19684300886
diabetes mellitus: induction in mice by encephalomyocarditis virus.hyperglycemia and lesions of the pancreatic islets of langerhans developed in some, but not all, adult mice infected with a variant of the encephalomyocarditis virus. large amounts of virus were recovered from the pancreas during acute stages of infection. at this time blood glucose concentrations were markedly elevated and the islets of langerhans exhibited focal necrosis and degranulation of beta cells. evidence of abnormal glucose metabolism persisted for varying periods after recovery from t ...19684300932
the effect of encephalomyocarditis-virus ribonucleic acid on amino acid incorporation in two mammalian cell-free protein-synthesizing systems. 19684301035
helminths as vehicles and synergists of microbial infections. 19684298164
a human interferon that crosses the species line. 19684298335
peroral infection and resistance to reinfection with encephalomyocarditis virus in the mouse. 19684298406
immunosuppressive effects of macrophage antiserum. 19684298549
interferon-stimulating and in vivo antiviral effects of various synthetic anionic polymers. 19684298648
effect of statolon-induced interferon on antibody formation.the effect of statolon-induced interferon on immune response was investigated. young adult swiss albino mice were immunized with chicken red blood cells or infectious mengovirus. the red blood cells were injected three times and the virus twice at 2-week intervals, with or without treatment with statolon 24 hr before the inoculations. the effect of interferon on antibody formation was measured by determinations of hemagglutinating, hemolytic, and virus-neutralizing antibodies in the sera of trea ...19684298812
isolation and properties of enterovirus receptors. 19684298835
antibodies to reoviruses, parainfluenza 3 virus, encephalomyocarditis virus and infectious bovine rhinotracheitis virus in porcine serums. 19684299231
specific cleavage of viral proteins as steps in the synthesis and maturation of enteroviruses. 19684299264
mengovirus replication in novikoff rat hepatoma and mouse l cells: effects on synthesis of host-cell macromolecules and virus-specific synthesis of ribonucleic acid.novikoff cells (strain n1s1-67) and l-67 cells, a nutritional mutant of the common strain of mouse l cells which grows in the same medium as n1s1-67 cells, were infected with mengovirus under identical experimental conditions. the synthesis of host-cell ribonucleic acid (rna) by either type of cell was not affected quantitatively or qualitatively until about 2 hr after infection, when viral rna synthesis rapidly displaced the synthesis of cellular rna. the rate of synthesis of protein by both ty ...19684176992
study of temperature-dependent inhibition of reproduction of some picornaviruses by aurantine and mitomycin. 19684179411
factors modifying host resistance to viral infection. 3. effect of whole body x-irradiation on experimental encephalomyocarditis virus infection in mice.the resistance of mice to encephalomyocarditis (emc) virus was markedly decreased by prior exposure to whole body x-irradiation. in contrast to non-irradiated controls, the course of emc virus infection in x-irradiated animals was characterized by (a) an enhanced mortality, (b) shortening of the incubation period, (c) higher levels of virus in the blood during the viremic phase and persistence of the viremia until death, (d) failure to develop detectable serum levels of neutralizing antibody, an ...19684297630
high mortality in a florida swine herd infected with the encephalomyocarditis virus. an accompanying epizootiologic survey. 19684297718
the effect of dimethyl sulfoxide (dmso) on cellular systems. 19684297822
[virus encephalitis]. 19684297917
isolation of encephalomyocarditis (emc) virus strains in india. 19684298069
virus-directed protein synthesis in different animal and human cells.the relative proportions of viral gene products (viral proteins) that are synthesized in different types of animal cells infected with the same rna virus inoculum were compared. the relative rates of synthesis of the various virus proteins late in infection were remarkably constant regardless of cell type infected. this was true in cell lines that produced only small amounts of virus and virus proteins, as well as in those that gave large yields of viruses and virus proteins.19684297294
the recognition of viral rna by mammalian ribosomes. an effect of interferon. 19684295296
molecular basis of the action of interferon. 19684295315
reversible inhibition of induction of mengovirus rna polymerase and of virus maturation in novikoff rat hepatoma cells by phenethyl alcohol. 19684295916
infectious disease exposure in a wild turkey population. 19684296150
effect of repeated inoculation of interferon preparations on infection of mice with encephalomyocarditis virus. 19684296289
analysis of molluscum-induced interference in mouse embryo cells: growth of encephalomyocarditis virus and dose-response relationships in molluscum-inhibited cultures. 19684296357
duration of prophylactic effect of statolon against mengovirus in mice.intraperitoneal injection of statolon into mice is known to exert a protective effect against a subsequent infection with a variety of viruses owing to stimulation of production of interferon. to study the duration of such protection, groups of mice were treated with 350 mug of statolon at 69, 55, 41, 27, 13, 6, or 1 day prior to a challenge with mengovirus. other groups were treated with 760 mug at 1 to 6 days before challenge. ten days after inoculation with the virus, ld(50) determinations we ...19684297000
controlled double infection with unrelated animal viruses. 19684297164
the pathogenicity in mice of aerosols of encephalomyocarditis group viruses or their infectious nucleic acids. 19684295061
virus-induced diabetes in mice. 19684302925
[stimulation of viral multiplication by anti-interferon serum: influence on the number of plaques]. 19684302943
factors modifying host resistance to virus infection: ii. enhanced susceptibility of mice to encephalomyocarditis virus infection during pregnancy. 196819971047
a comparison of the efficacy of endogenous, exogenous, and combined endogenous-exogenous interferon in the treatment of mice infected with encephalomyocarditis virus. 19694302959
changes in virus attachment and other surface properties of l4946 mouse leukemia cells on adaptation of growth in tissue culture. 19694303868
physical and chemical studies of mengo virus variants. ii. chromatographic behavior and chemical composition. 19694304576
the interaction of tritium-labelled mengo virus rna and l cells: the effects of dmso and deae-dextran. 19694305634
utilization of substrate analogs by mengovirus induced rna polymerase. 19694305637
[evidence for bicatenoid ribonucleic acids during the viral multiplication cycle by interferon induction in mice]. 19694305901
comparison of the antiviral activity in vitro of some non-steroidal anti-inflammatory drugs. 19694306296
contrasting effects of polycations on plaquing efficiency of encephalomyocarditis virus variants.polycation treatment of l cell monolayers affected plaquing efficiency of both the r(+) and r variants of the encephalomyocarditis virus. plaque formation by r(+) variant was decreased markedly by three structurally different types of synthetic basic polymers, diethylaminoethyl dextran, hexadimethrene (polybrene), and basic polyamino acids. in contrast, these same substances increased substantially the number of plaques formed by the r variant. the effect on the two variants was observed when po ...19694306302
[the infection of mice with the mouse hepatitis virus (mhv 3). i. analysis of several experimental data from the view point of the single hit theory]. 19694306364
virus growth inhibition by ethidium chloride and other dyes. 19694306365
[action of pyronine on the multiplication of encephalomyocarditis virus (emc) in mice]. 19694306646
visualisation in the electron microscope and size of rna from animal cells. 19694306663
a possible subunit structure of rous sarcoma virus rna. 19694306716
refractoriness of kb cell cultures carrying japanese b encephalitis virus to encephalomyocarditis virus infection. 19694307239
[induction of interferon synthesis by double-stranded rna. i. application to the study of the multiplication cycle of mengo virus]. 19694307590
the immunologic response of the mouse to aerosols of an attenuated encephalomyocarditis virus strain. 19694307760
the role of individual spleen cells in the interferon response of the intact mouse.a method is described for the detection of interferon production by individual spleen cells of mice after intravenous virus infection. although mouse spleen plays a major role in the total interferon response to newcastle disease virus, the number of spleen cells participating is a small fraction of the total, suggesting that interferon formation is to some extent a specialized cell function. monolayers of mouse embryo cells, after brief contact with agar-suspended spleen cells from interferon-p ...19694307872
propagation of mm virus in l cells.mm virus (mouse-brain stock) replicated to a limited extent in l cells without cytopathic effects; the average yield was less than 1 plaque-forming unit/cell. passage in bhk-21 cells resulted in mm virus [mm(bhk)] which replicated to high titers (200 to 300 plaque-forming units/cell) in l cells with complete cytopathic effects. appearance of mature mm(bhk) virus in l-cell cultures begins 4 hr after infection and is completed by 8 hr. release of mature virus was slow (less than 1% at 8 hr) but wa ...19694307880
propagation of mm virus in continuous cell lines.baby hamster kidney (bhk), mccoy, and l cell lines were found to be suitable for isolation of mm virus from infected mouse brain tissue. the virus was recovered in high titer in the first passage in bhk and mccoy cells, with concomitant cytopathic effect (cpe). in l cells, virus yield was lower than in the other two cell lines and cpe was incomplete. adaptation of the virus to bhk and mccoy cells by serial passages was evidenced by accelerated development of the cpe and increase in the virus tit ...19694307881
effect of ultraviolet irradiation and actinomycin d on polyoma virus replication in mouse embryo cell cultures.ultraviolet irradiation and actinomycin d impair the capacity of mouse embryo (me) cells to support the replication of polyoma virus, but not of encephalomyocarditis (emc) virus. the loss in capacity for polyoma virus synthesis was an "all-or-none" effect and followed closely upon the loss in cellular capacity for clone formation. cells treated with either agent produced polyoma "t" antigen, but did not synthesize polyoma structural protein. infection of untreated me cells with polyoma virus pro ...19694307903
encephalomyocarditis virus ribonucleic acid polymerase associated with 150s cytoplasmic particles.cytoplasmic particles which sedimented at 150s were the smallest structures containing detectable viral ribonucleic acid polymerase in mouse cells infected with encephalomyocarditis virus.19694307906
[ribonucleic acids and proteins from cells infected by mouse encephalomyocarditis virus (emc) in the presence of pyronine]. 19694308044
[persistance of a stimulated character in primitive virus cultivated in the presence of anti-interferon serum]. 19694308446
antiviral and cytotoxic effects of mycophenolic acid. 19694308492
influence of statolon on resistance of mice to influenza.various interferon inducers are known to elicit protection against lethal or infecting doses of certain viral agents. because of the relatively high morbidity rate of influenza and its seasonal occurrence, we wished to determine whether statolon-induced interferon might be effective in controlling this disease. mice were treated intraperitoneally with statolon and challenged with influenza a(2) virus by the intranasal route. although interferon was present in the serum at the time of virus admin ...19694308934
adjuvant properties of alginate in bacterial, viral and protein vaccines. 19694309278
resistance to virus challenge in mice infected with protozoa or bacteria. 19694309474
mengovirus-induced cytopathic effect in l-cells: protective effect of interferon.the effect of interferon on mengovirus-induced cytopathic effect (cpe) in l cells, the cut-off of host-cell protein synthesis, and production of mature virus were found to be dependent on the concentration of interferon. cpe and inhibition of host protein synthesis were not affected until the concentration of interferon was increased 100-fold over that required to reduce viral yields by 90%.19694309883
polyinosinic-cytidylic acid complex (poly i:c) and viral infections in mice. 19694310180
purification of encephalomyocarditis virus. 19694310464
psychosocial factors modifying host resistance to experimental infections. 19694310921
a persistent and inapparent infection of l cells with the virus of lymphocytic choriomeningitis. 19694186351
synthesis of functional proteins in x-irradiated mammalian cells. 19694302397
behaviour of infectious rna from four different viruses in continuously subcultured aedes aegypti mosquito embryo cells. 19694302398
competitive inhibition of uridine incorporation by 6-azauridine in uninfected and mengovirus-infected novikoff hepatoma cells. 19694311690
host-dependent restriction of mengovirus replication.mengovirus infection of a restrictive cell line, maden's bovine kidney (mdbk), results in a virus yield 1,000-fold less than that obtained from productively infected cell lines such as l cells or ehrlich ascites tumor cells (eat). cells of both types of host systems are infected with comparable efficiencies and are completely killed as a consequence of infection. infective center assays, coupled with the observation of total cell killing, suggest that comparable numbers of cells synthesize viral ...19694311796
insensitivity of mitochondrial rna synthesis to mengovirus infection in cho cells. 19694311805
[fluorescence serology studies on the effects of antiviral agents on virus replication. i. the action of beta-2-dl-thienyl alanine on the replication of mengo virus]. 19694313030
[induction of interferon in the brain of baby mice by viruses of the tick-borne encephalitis (tbe) complex]. 19694313032
effect of prehumidification on sampling of selected airborne viruses.studies were undertaken to determine if a prewetting device (humidifier bulb) used in combination with an all glass impinger (agi-30) would increase the recovery of airborne mengovirus-37a, vesicular stomatitis virus (vsv), and the s-13 coliphage. suspensions of t3 coliphage with mengovirus-37a, vsv, or s-13 were aerosolized and collected by using the agi-30-humidifier bulb combination to sample the aerosols before and after shifts in relative humidities (rh). these studies revealed the followin ...19694313171
rapid plaque assay for encephalomyocarditis virus.a liquid overlay plaquing technique is described which offers a rapid and simple plaque assay system for small plaque variants of encephalomyocarditis virus.19694313172
death and transfiguration of a problem. 19694313270
effect of lyophilization on picornaviruses. (brief report). 19694315819
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