Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| effect of polycations on growth and dissemination of the encephalomyocarditis virus in mice. | pathogenicity of the encephalomyocarditis (emc) virus for adult mice was increased when polycations of diverse type were mixed with virus and inoculated by the subcutaneous or intraperitoneal routes. diethylaminoethyl (deae) dextran, hexadimethrine (polybrene), polymyxin b, polylysine, and calf thymus histone in various concentrations stimulated multiplication of virus in tissues at the injection site and enhanced entry of virus into the blood. the nonpathogenic r(+) variant of emc which grows l ... | 1967 | 4316242 |
| distribution of cell receptors and simple sugar inhibitors during encephalomyocarditis virus-cell union. | encephalomyocarditis (emc) virus was studied for ability to agglutinate erythrocytes of various species. human, rat, and guinea pig erythrocytes, as well as those from young rabbits, were readily agglutinated. cells from older rabbits absorbed virus poorly, and showed little agglutination. uptake of virus by rabbit brain also diminished with age. various mouse tissues absorbed virus about equally well. hemagglutination-inhibition studies demonstrated that a number of simple sugars, particularly ... | 1967 | 4318947 |
| separation of plaque-type variants of encephalomyocarditis virus by chromatography on calcium phosphate. | encephalomyocarditis (emc) virus (k-2 strain) was separated into two distinct peaks of optical density by chromatography on calcium phosphate, eluting at 0.17 and 0.31 m, respectively. the virus in these peaks could not be distinguished by infectivity (plaque-forming units), hemagglutinin activity, electron microscopic appearance, sedimentation coefficient, or base ratios. however, variants producing large plaques predominated in the first peak eluted, whereas variants producing small plaques we ... | 1967 | 4318950 |
| interaction of encephalomyocarditis virus with ultraviolet-irradiated host cells. | ultraviolet light (uv) impaired the capacity of l cells to support growth of encephalomyocarditis virus. the loss of capacity was partially restored by high multiplicity of infection (moi). this phenomenon was not due to an increased probability of an infectious virus particle reaching a site of replication undamaged by uv, since uv-inactivated virus at high moi induced restoration of the capacity to support multiplication of nonirradiated virus adsorbed at low moi. multiplicity reactivation of ... | 1967 | 4318958 |
| effect of multiplicity of infection on the rate of protein synthesis in encephalomyocarditis virus-infected l cells. | 1967 | 4382471 | |
| peculiarities of the antiviral action of dibenzylphosphinic acid. | 1967 | 4382472 | |
| an interferon like substance induced by mannans. | 1967 | 4382481 | |
| effect of a space cabin environment on viral infection. | 1967 | 4383045 | |
| the temperature requirement for interferon production in cells stimulated by newcastle disease virus or microbial agents in vitro. | 1967 | 4383884 | |
| production of interferon-like inhibitor in chickens after secondary induction by bacteria and virus. | 1968 | 4385157 | |
| potentiation of the antiviral activity of interferon by histones. | 1968 | 4386015 | |
| induction of interferon activity in mouse serum by phase i coxiella burneti antigen. | 1968 | 4386026 | |
| inactivation of single- and double-stranded ribonucleic acid of encephalomyocarditis virus by ultraviolet light. | 1968 | 4387327 | |
| a temporal and structural relationship between viral rna polymerase and nicotinamide adenine dinucleotide pyrophosphorylase in the cytoplasm of krebs-2 ascites cells infected with encephalomyocarditis virus. | 1968 | 4329661 | |
| synthesis of ribonucleic acid by mengovirus-induced rna polymerase in vitro: nature of products and of rnase-resistant intermediate. | 1968 | 4329736 | |
| [oral immunization with non living microorganisms or their antigens. 8. comparing experiments to vaccination by inhalation and nasal, oral, and rectal route]. | 1968 | 4317590 | |
| [on a case of encephalomyocarditis]. | 1968 | 4313601 | |
| destruction of l cells by mengo virus: use of interferon to study the mechanism. | interferon, when added to l cells, inhibited the synthesis of infectious mengo viral ribonucleic acid, hemagglutinins, and infectious virus by 85 to 95%. serum-blocking antigens were also reduced by the action of interferon, but threefold excess amounts of these antigens accumulated in interferon-treated cultures above the amounts expected for the quantity of infectious virus that was produced in these cultures. radioautographic analysis showed that 28 to 36% of the cells of an interferon-treate ... | 1968 | 4301505 |
| evidence of an infective component sensitive to ribonuclease in the brain homogenate fo mice inoculated with mm virus. | 1968 | 4301715 | |
| the antiviral activity of 3,4-dihydro-1-isoquinolineacetamide hydrochloride in vitro, in ovo, and in small laboratory animals. | 1968 | 4301999 | |
| replication of mengovirus in hela cells preinfected with nonreplicating poliovirus. | the replication of mengovirus in hela cells preinfected with poliovirus in the presence of 10(-3) m guanidine was investigated. although host cell protein synthesis is inhibited by the presence of nonreplicating poliovirus, it is found that mengovirus ribonucleic acid (rna) and protein synthesis proceed normally under the same conditions. furthermore, no effects on mengovirus growth by poliovirus can be detected either when mengo protein synthesis is interrupted by acti-dione or when its rna syn ... | 1968 | 4302186 |
| survival of a picornavirus and its infectious ribonucleic acid after aerosolization. | 1968 | 4302283 | |
| enhancement of mengovirus nucleic acid infectivity by putrescine. | 1968 | 4300093 | |
| analysis of nearest neighbour base frequencies in the rna of a mammalian virus: encephalomyocarditis virus. | 1968 | 4300110 | |
| [characterization of various representatives of the columbia-sk virus group with fluorescent antibodies. ii. adaptation of columbia-sk viruses to l cells]. | 1968 | 4300583 | |
| ultraviolet inactivation of mm virus rna in terms of sodium chloride concentrations. | 1968 | 4300886 | |
| diabetes mellitus: induction in mice by encephalomyocarditis virus. | hyperglycemia and lesions of the pancreatic islets of langerhans developed in some, but not all, adult mice infected with a variant of the encephalomyocarditis virus. large amounts of virus were recovered from the pancreas during acute stages of infection. at this time blood glucose concentrations were markedly elevated and the islets of langerhans exhibited focal necrosis and degranulation of beta cells. evidence of abnormal glucose metabolism persisted for varying periods after recovery from t ... | 1968 | 4300932 |
| the effect of encephalomyocarditis-virus ribonucleic acid on amino acid incorporation in two mammalian cell-free protein-synthesizing systems. | 1968 | 4301035 | |
| helminths as vehicles and synergists of microbial infections. | 1968 | 4298164 | |
| a human interferon that crosses the species line. | 1968 | 4298335 | |
| peroral infection and resistance to reinfection with encephalomyocarditis virus in the mouse. | 1968 | 4298406 | |
| immunosuppressive effects of macrophage antiserum. | 1968 | 4298549 | |
| interferon-stimulating and in vivo antiviral effects of various synthetic anionic polymers. | 1968 | 4298648 | |
| effect of statolon-induced interferon on antibody formation. | the effect of statolon-induced interferon on immune response was investigated. young adult swiss albino mice were immunized with chicken red blood cells or infectious mengovirus. the red blood cells were injected three times and the virus twice at 2-week intervals, with or without treatment with statolon 24 hr before the inoculations. the effect of interferon on antibody formation was measured by determinations of hemagglutinating, hemolytic, and virus-neutralizing antibodies in the sera of trea ... | 1968 | 4298812 |
| isolation and properties of enterovirus receptors. | 1968 | 4298835 | |
| antibodies to reoviruses, parainfluenza 3 virus, encephalomyocarditis virus and infectious bovine rhinotracheitis virus in porcine serums. | 1968 | 4299231 | |
| specific cleavage of viral proteins as steps in the synthesis and maturation of enteroviruses. | 1968 | 4299264 | |
| mengovirus replication in novikoff rat hepatoma and mouse l cells: effects on synthesis of host-cell macromolecules and virus-specific synthesis of ribonucleic acid. | novikoff cells (strain n1s1-67) and l-67 cells, a nutritional mutant of the common strain of mouse l cells which grows in the same medium as n1s1-67 cells, were infected with mengovirus under identical experimental conditions. the synthesis of host-cell ribonucleic acid (rna) by either type of cell was not affected quantitatively or qualitatively until about 2 hr after infection, when viral rna synthesis rapidly displaced the synthesis of cellular rna. the rate of synthesis of protein by both ty ... | 1968 | 4176992 |
| study of temperature-dependent inhibition of reproduction of some picornaviruses by aurantine and mitomycin. | 1968 | 4179411 | |
| factors modifying host resistance to viral infection. 3. effect of whole body x-irradiation on experimental encephalomyocarditis virus infection in mice. | the resistance of mice to encephalomyocarditis (emc) virus was markedly decreased by prior exposure to whole body x-irradiation. in contrast to non-irradiated controls, the course of emc virus infection in x-irradiated animals was characterized by (a) an enhanced mortality, (b) shortening of the incubation period, (c) higher levels of virus in the blood during the viremic phase and persistence of the viremia until death, (d) failure to develop detectable serum levels of neutralizing antibody, an ... | 1968 | 4297630 |
| high mortality in a florida swine herd infected with the encephalomyocarditis virus. an accompanying epizootiologic survey. | 1968 | 4297718 | |
| the effect of dimethyl sulfoxide (dmso) on cellular systems. | 1968 | 4297822 | |
| [virus encephalitis]. | 1968 | 4297917 | |
| isolation of encephalomyocarditis (emc) virus strains in india. | 1968 | 4298069 | |
| virus-directed protein synthesis in different animal and human cells. | the relative proportions of viral gene products (viral proteins) that are synthesized in different types of animal cells infected with the same rna virus inoculum were compared. the relative rates of synthesis of the various virus proteins late in infection were remarkably constant regardless of cell type infected. this was true in cell lines that produced only small amounts of virus and virus proteins, as well as in those that gave large yields of viruses and virus proteins. | 1968 | 4297294 |
| the recognition of viral rna by mammalian ribosomes. an effect of interferon. | 1968 | 4295296 | |
| molecular basis of the action of interferon. | 1968 | 4295315 | |
| reversible inhibition of induction of mengovirus rna polymerase and of virus maturation in novikoff rat hepatoma cells by phenethyl alcohol. | 1968 | 4295916 | |
| infectious disease exposure in a wild turkey population. | 1968 | 4296150 | |
| effect of repeated inoculation of interferon preparations on infection of mice with encephalomyocarditis virus. | 1968 | 4296289 | |
| analysis of molluscum-induced interference in mouse embryo cells: growth of encephalomyocarditis virus and dose-response relationships in molluscum-inhibited cultures. | 1968 | 4296357 | |
| duration of prophylactic effect of statolon against mengovirus in mice. | intraperitoneal injection of statolon into mice is known to exert a protective effect against a subsequent infection with a variety of viruses owing to stimulation of production of interferon. to study the duration of such protection, groups of mice were treated with 350 mug of statolon at 69, 55, 41, 27, 13, 6, or 1 day prior to a challenge with mengovirus. other groups were treated with 760 mug at 1 to 6 days before challenge. ten days after inoculation with the virus, ld(50) determinations we ... | 1968 | 4297000 |
| controlled double infection with unrelated animal viruses. | 1968 | 4297164 | |
| the pathogenicity in mice of aerosols of encephalomyocarditis group viruses or their infectious nucleic acids. | 1968 | 4295061 | |
| virus-induced diabetes in mice. | 1968 | 4302925 | |
| [stimulation of viral multiplication by anti-interferon serum: influence on the number of plaques]. | 1968 | 4302943 | |
| factors modifying host resistance to virus infection: ii. enhanced susceptibility of mice to encephalomyocarditis virus infection during pregnancy. | 1968 | 19971047 | |
| a comparison of the efficacy of endogenous, exogenous, and combined endogenous-exogenous interferon in the treatment of mice infected with encephalomyocarditis virus. | 1969 | 4302959 | |
| changes in virus attachment and other surface properties of l4946 mouse leukemia cells on adaptation of growth in tissue culture. | 1969 | 4303868 | |
| physical and chemical studies of mengo virus variants. ii. chromatographic behavior and chemical composition. | 1969 | 4304576 | |
| the interaction of tritium-labelled mengo virus rna and l cells: the effects of dmso and deae-dextran. | 1969 | 4305634 | |
| utilization of substrate analogs by mengovirus induced rna polymerase. | 1969 | 4305637 | |
| [evidence for bicatenoid ribonucleic acids during the viral multiplication cycle by interferon induction in mice]. | 1969 | 4305901 | |
| comparison of the antiviral activity in vitro of some non-steroidal anti-inflammatory drugs. | 1969 | 4306296 | |
| contrasting effects of polycations on plaquing efficiency of encephalomyocarditis virus variants. | polycation treatment of l cell monolayers affected plaquing efficiency of both the r(+) and r variants of the encephalomyocarditis virus. plaque formation by r(+) variant was decreased markedly by three structurally different types of synthetic basic polymers, diethylaminoethyl dextran, hexadimethrene (polybrene), and basic polyamino acids. in contrast, these same substances increased substantially the number of plaques formed by the r variant. the effect on the two variants was observed when po ... | 1969 | 4306302 |
| [the infection of mice with the mouse hepatitis virus (mhv 3). i. analysis of several experimental data from the view point of the single hit theory]. | 1969 | 4306364 | |
| virus growth inhibition by ethidium chloride and other dyes. | 1969 | 4306365 | |
| [action of pyronine on the multiplication of encephalomyocarditis virus (emc) in mice]. | 1969 | 4306646 | |
| visualisation in the electron microscope and size of rna from animal cells. | 1969 | 4306663 | |
| a possible subunit structure of rous sarcoma virus rna. | 1969 | 4306716 | |
| refractoriness of kb cell cultures carrying japanese b encephalitis virus to encephalomyocarditis virus infection. | 1969 | 4307239 | |
| [induction of interferon synthesis by double-stranded rna. i. application to the study of the multiplication cycle of mengo virus]. | 1969 | 4307590 | |
| the immunologic response of the mouse to aerosols of an attenuated encephalomyocarditis virus strain. | 1969 | 4307760 | |
| the role of individual spleen cells in the interferon response of the intact mouse. | a method is described for the detection of interferon production by individual spleen cells of mice after intravenous virus infection. although mouse spleen plays a major role in the total interferon response to newcastle disease virus, the number of spleen cells participating is a small fraction of the total, suggesting that interferon formation is to some extent a specialized cell function. monolayers of mouse embryo cells, after brief contact with agar-suspended spleen cells from interferon-p ... | 1969 | 4307872 |
| propagation of mm virus in l cells. | mm virus (mouse-brain stock) replicated to a limited extent in l cells without cytopathic effects; the average yield was less than 1 plaque-forming unit/cell. passage in bhk-21 cells resulted in mm virus [mm(bhk)] which replicated to high titers (200 to 300 plaque-forming units/cell) in l cells with complete cytopathic effects. appearance of mature mm(bhk) virus in l-cell cultures begins 4 hr after infection and is completed by 8 hr. release of mature virus was slow (less than 1% at 8 hr) but wa ... | 1969 | 4307880 |
| propagation of mm virus in continuous cell lines. | baby hamster kidney (bhk), mccoy, and l cell lines were found to be suitable for isolation of mm virus from infected mouse brain tissue. the virus was recovered in high titer in the first passage in bhk and mccoy cells, with concomitant cytopathic effect (cpe). in l cells, virus yield was lower than in the other two cell lines and cpe was incomplete. adaptation of the virus to bhk and mccoy cells by serial passages was evidenced by accelerated development of the cpe and increase in the virus tit ... | 1969 | 4307881 |
| effect of ultraviolet irradiation and actinomycin d on polyoma virus replication in mouse embryo cell cultures. | ultraviolet irradiation and actinomycin d impair the capacity of mouse embryo (me) cells to support the replication of polyoma virus, but not of encephalomyocarditis (emc) virus. the loss in capacity for polyoma virus synthesis was an "all-or-none" effect and followed closely upon the loss in cellular capacity for clone formation. cells treated with either agent produced polyoma "t" antigen, but did not synthesize polyoma structural protein. infection of untreated me cells with polyoma virus pro ... | 1969 | 4307903 |
| encephalomyocarditis virus ribonucleic acid polymerase associated with 150s cytoplasmic particles. | cytoplasmic particles which sedimented at 150s were the smallest structures containing detectable viral ribonucleic acid polymerase in mouse cells infected with encephalomyocarditis virus. | 1969 | 4307906 |
| [ribonucleic acids and proteins from cells infected by mouse encephalomyocarditis virus (emc) in the presence of pyronine]. | 1969 | 4308044 | |
| [persistance of a stimulated character in primitive virus cultivated in the presence of anti-interferon serum]. | 1969 | 4308446 | |
| antiviral and cytotoxic effects of mycophenolic acid. | 1969 | 4308492 | |
| influence of statolon on resistance of mice to influenza. | various interferon inducers are known to elicit protection against lethal or infecting doses of certain viral agents. because of the relatively high morbidity rate of influenza and its seasonal occurrence, we wished to determine whether statolon-induced interferon might be effective in controlling this disease. mice were treated intraperitoneally with statolon and challenged with influenza a(2) virus by the intranasal route. although interferon was present in the serum at the time of virus admin ... | 1969 | 4308934 |
| adjuvant properties of alginate in bacterial, viral and protein vaccines. | 1969 | 4309278 | |
| resistance to virus challenge in mice infected with protozoa or bacteria. | 1969 | 4309474 | |
| mengovirus-induced cytopathic effect in l-cells: protective effect of interferon. | the effect of interferon on mengovirus-induced cytopathic effect (cpe) in l cells, the cut-off of host-cell protein synthesis, and production of mature virus were found to be dependent on the concentration of interferon. cpe and inhibition of host protein synthesis were not affected until the concentration of interferon was increased 100-fold over that required to reduce viral yields by 90%. | 1969 | 4309883 |
| polyinosinic-cytidylic acid complex (poly i:c) and viral infections in mice. | 1969 | 4310180 | |
| purification of encephalomyocarditis virus. | 1969 | 4310464 | |
| psychosocial factors modifying host resistance to experimental infections. | 1969 | 4310921 | |
| a persistent and inapparent infection of l cells with the virus of lymphocytic choriomeningitis. | 1969 | 4186351 | |
| synthesis of functional proteins in x-irradiated mammalian cells. | 1969 | 4302397 | |
| behaviour of infectious rna from four different viruses in continuously subcultured aedes aegypti mosquito embryo cells. | 1969 | 4302398 | |
| competitive inhibition of uridine incorporation by 6-azauridine in uninfected and mengovirus-infected novikoff hepatoma cells. | 1969 | 4311690 | |
| host-dependent restriction of mengovirus replication. | mengovirus infection of a restrictive cell line, maden's bovine kidney (mdbk), results in a virus yield 1,000-fold less than that obtained from productively infected cell lines such as l cells or ehrlich ascites tumor cells (eat). cells of both types of host systems are infected with comparable efficiencies and are completely killed as a consequence of infection. infective center assays, coupled with the observation of total cell killing, suggest that comparable numbers of cells synthesize viral ... | 1969 | 4311796 |
| insensitivity of mitochondrial rna synthesis to mengovirus infection in cho cells. | 1969 | 4311805 | |
| [fluorescence serology studies on the effects of antiviral agents on virus replication. i. the action of beta-2-dl-thienyl alanine on the replication of mengo virus]. | 1969 | 4313030 | |
| [induction of interferon in the brain of baby mice by viruses of the tick-borne encephalitis (tbe) complex]. | 1969 | 4313032 | |
| effect of prehumidification on sampling of selected airborne viruses. | studies were undertaken to determine if a prewetting device (humidifier bulb) used in combination with an all glass impinger (agi-30) would increase the recovery of airborne mengovirus-37a, vesicular stomatitis virus (vsv), and the s-13 coliphage. suspensions of t3 coliphage with mengovirus-37a, vsv, or s-13 were aerosolized and collected by using the agi-30-humidifier bulb combination to sample the aerosols before and after shifts in relative humidities (rh). these studies revealed the followin ... | 1969 | 4313171 |
| rapid plaque assay for encephalomyocarditis virus. | a liquid overlay plaquing technique is described which offers a rapid and simple plaque assay system for small plaque variants of encephalomyocarditis virus. | 1969 | 4313172 |
| death and transfiguration of a problem. | 1969 | 4313270 | |
| effect of lyophilization on picornaviruses. (brief report). | 1969 | 4315819 |