Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| amino-terminal sequence of baboon type c virus p30. | 1975 | 166494 | |
| epidemiological studies on feline leukaemia virus infection. i. a serological survey in urban cats. | a survey of the incidence of feline leukaemia virus (felv) infection in cats in a large urban area was made by studying the prevalence of antibodies to feline leukaemia virus-associated cell membrane antigens. two serological tests were used, immunofluorescence and a mixed immunoglobulin rosette technique. the overall incidence of cats with antibodies was 40%, contrasting with 6% in the surrounding rural area. only 6% of urban kittens were positive while 50% of adults had antibodies. the inciden ... | 1975 | 166947 |
| an unusual case of feline leukemia and an associated syncytium-forming virus. | a 3-year-old female siamese cat was admitted to a local animal hospital with a history of recent extreme lethargy and anorexia. a hemorrhagic tumor was removed from an area of oral buccal skin and diagnosed histopathologically as lymphosarcoma. rapid physical deterioration occurred, and the cat became moribund 2 weeks after surgical operation. necropsy revealed at least 200 spherical hemorrhagic neoplastic nodules attached to the omentum, mesentery, and peritoneum. examination of histopathologic ... | 1975 | 167623 |
| electron microscope studies of tumor virus rna. | 1975 | 169036 | |
| amino acid sequence homology of mammalian type c rna virus major internal proteins. | the nh2-terminal amino acid sequence of the major group-specific antigen, the major internal virion protein (p30; approximate molecular weight 30,000) of several mammalian type c rna viruses was determined by the edman degradation procedure using an automated protein sequenator. all of the proteins analyzed show a high degree of over-all sequence homology and also contain specific regions or single residues. all p30s begin with the sequence prolyl-leucylarginyl (pro-leu-arg) and have an invarian ... | 1975 | 169234 |
| establishment of two canine sarcoma cell lines: productive infection with feline leukemia virus. | two canine sarcoma cell lines (11028, 11031) were established in vitro and have been transferred 213 and 306 times, respectively, since 1970. these cell lines had a chromosome pattern consistent with their canine origin. both cultures were infected with feline leukemia virus (felv), which caused a morphologic and karyotypic changes. the cells became rounded after infection with felv and both cultures showed the presence of a single, large, acrocentric chromosome considered to be a marker chromos ... | 1975 | 169374 |
| feline oncornavirus-associated cell membrane antigen. iv. antibody titers in cats with naturally occurring leukemia, lymphoma, and other diseases. | cats with naturally occurring leukemia and lymphoma had low or negative humoral antibody titers to the feline oncornavirus-associated cell membrane antigen (focma). geographic differences were seen in the relative frequencies of various forms of lymphoproliferative neoplasms. lymphatic leukemia and thymic lymphoma were most common in boston, whereas alimentary lymphoma was most frequent in glasgow. no significant differences were found in geometric mean focma antibody titers for the various form ... | 1975 | 169377 |
| properties of feline leukemia virus. iii. analysis of the rna. | the kinetics of virus labeling was used to study the maturation of viral rna in the rickard strain of feline leukemia virus. viral rna labeled over differing intervals was characterized by gel electrophoresis and velocity sedimentation in sucrose gradients made up in aqueous buffer and 99% dimethyl sulfoxide. labeled virus was found within 30 min after adding radioactive uridine to the cells and production of labeled virus reached a maximum at 4 to 5 h after pulse labeling. native rna from felin ... | 1975 | 169389 |
| editorial: leukaemia in animals and man. | 1975 | 169460 | |
| viral leukaemia in domestic cats. | 1975 | 169461 | |
| [the incidence of lymphosarcoma (leukaemia) and feline leukaemia virus (felv) in cats in the netherlands (author's transl)]. | seven different groups of cats were examined to study the incidence and distribution of feline leukaemia virus (felv) in the netherlands. the indirect fluorescent antibody (ifa) technique was used to detect felv antigen. of the cats with lymphosarcoma (leukaemia), 73.2 per cent and of those with infectious peritonitis, 32.4 per cent were found to be positive for felv antigen. of the sixty-six cats with other tumours, only one, a cat with carcinoma of the mammary gland; was positive for felv anti ... | 1975 | 169604 |
| complement-fixation-inhibition as a test for antibodies in cats and humans to c-type rna tumor virus antigen. | the complement-fixation-inhibition (cfi) test was evaluated as a means of detecting humoral antibodies in cat sera and in human sera to mammalian c-type rna virus interspecies antigen(s). cfi antibody titers of greater than or equal 1:2 were detected in sera from all tumor bearing (23) and normal cats (23), however, sera from most germ free cats were negative. when the same cat sera were tested for blocking antibody by the paired radioiodine labeled antibody technique the correlation between the ... | 1975 | 169819 |
| immune response of healthy and leukemic cats to the feline oncornavirus-associated cell membrane antigen. | feline leukemia is an infectious disease caused by a horizontally transmitted virus. infection of animals or cultured cells with feline oncornaviruses results in the expression of a specific cell membrane antigen, feline oncornavirus-associated cell membrane antigen (focma). the humoral antibody response to focma is directly correlated with tumor progression. the measurement of this antibody is a useful tool for determining virus exposure. using this procedure it was determined that cats living ... | 1975 | 169820 |
| in vitro host range of feline leukemia virus. | 1975 | 169821 | |
| horizontal transmission of feline leukemia virus in cats. | traditionally, cancer has not been considered an infectious disease although some multiple cases of leukemia in man and cattle have been reported. the discovery that feline lymphosarcoma was associated with an rna virus (feline leukemia virus(felv)) meant that infectious transmission of the disease was a possibility. the critical question was whether the predominant method of transmission from one animal to another was 'vertical' (via the gametes) or 'horizontal' (via contagion or infection). a ... | 1975 | 169834 |
| in vitro transformation of cells from human neoplasms. | the possible involvement of rna tumor virus genomes in human cell transformation was investigated. forty-nine cell cultures from neoplastic, normal, or embryo tissues were examined for transformation, following inoculation of murine leukemia virus (mulv), feline leukemia virus (felv) grown in human cells, or bone marrow aspirates from leukemia patients. five cultures exhibited transformation (1 after inoculation of mulv grown in human cells; 4 after inoculation of human leukemic bone marrow), an ... | 1975 | 169838 |
| sarcomas induced in rats by feline rna virus. | 1975 | 169839 | |
| vaccination against feline leukaemia virus using a cell membrane antigen system. | cats inoculated with live feline lymphoblastoid cells of the fl74 line developed high titres of antibody to feline oncornavirus-associated cell membrane antigen (focma). eight cats were subsequently challenged with a large dose of feline leukaemia virus (felv) of a highly pathogenic strain. all resisted infection while 10 cats given the challenge virus alone became infected. the felv produced by fl74 cells was shown to be of extremely low infectivity in cats and in cultured feline cells. cats in ... | 1975 | 170211 |
| natural history of feline leukaemia virus. | 1975 | 170454 | |
| segregation of rd-114 and fel-v-related sequences in crosses between domestic cat and leopard cat. | 1975 | 170535 | |
| human serum lyses rna tumour viruses. | 1975 | 170540 | |
| an in vitro focus-induction assay for xenotropic murine leukemia virus, feline leukemia virus c, and the feline--primate viruses rd-114/ccc/m-7. | 1975 | 170737 | |
| the relation of immune response to pathogenesis, vaccination and epidemiology in virus induced leukaemia. | the antigenic systems of oncornaviruses and particularly feline leukaemia virus (felv) are reviewed briefly. the use of immunological methods in studying the epidemiology of the disease is described. the incidence of felv infection as judged by a serological survey is at least 100 times greater than that of leukaemia in the cat population. horizontal transmission, due to virus replication in respiratory and alimentary epithelial cells, is common. a method of producing high titres of antibody aga ... | 1975 | 170952 |
| electrophoretic mobilities of rna tumor viruses. studies by doppler-shifted light scattering spectroscopy. | we have used laser beat frequency light scattering spectroscopy to measure, at several ph values, the electrophoretic mobilities of purified avian myeloblastosis (amv), murine leukemia (mulv), murine mammary tumor (mumtv), and feline leukemia (felv) viruses. the mobilities of these viruses are similar at ph greater than or equal to7 (-2.7 to -3.2 x 10(-4) (cm/sec)/(v/cm). the isoelectric points of mulv and amv are apparently less than ph 3, whereas for felv the data could be interpreted to indic ... | 1975 | 170961 |
| characterization of non-producer human cells induced by kirsten sarcoma virus. | non-producer (np) human cells induced by the kirsten sarcoma virus were characterized. these morphologically altered np cells produced neither infectious virus nor complement-fixing antigens of the murine sarcoma-leukemia virus complex. the np cells did not release rna-dependent dna polymerase and type-c virus particles with a density of approximately 1.15 g/ml in sucrose gradients by 3h-uridine labelling. the np cells produced tumors when transplanted subcutaneously into athymic nude mice. the ... | 1975 | 171229 |
| symposium: characterization of oncornaviruses and related viruses--a report. | 1975 | 171431 | |
| serological analysis of an oncornavirus (pmf virus) detected in malignant permanent human cell lines. | immunodiffusion analysis of the pmf virus which was detected in malignant permanent human cell lines revealed positive reactions with antisera against the mason-pfizer monkey virus (mpmv). no cross-reactivity was demonstrated with murine leukemia virus (mulv), rat leukemia virus (ralv), hamster leukemia virus (halv), feline leukemia virus (felv), simian (woolly monkey) sarcoma virus (ssv-1) and mouse mammary tumor virus (mtv). the cross-reactive antigens of the pmf virus and the mpmv are conside ... | 1975 | 171892 |
| horizontally and vertically transmitted oncornaviruses of cats. | 1975 | 174397 | |
| cat leukemia and its viruses. | 1975 | 174410 | |
| [feline leukemogenic and sarcomatogenic viruses]. | feline leukemia and sarcoma viruses (felv, fesv) are rna viruses, belonging to the oncornavirus group. they possess common morphological, biochemical and immunological properties, with viruses of leukemia and sarcoma already known in others mammalian and avian species. felv is widely present in feline population and its transmission is by horizontal way. felv and fesv are oncogenic for others species, i.e., dog and some non-human primates but as far as we know, the human receptivity is not estab ... | 1975 | 175893 |
| neoplasms of cats caused by oncornaviruses. | 1975 | 172836 | |
| immunosurveillance of naturally occurring feline leukemia. | when compared to their housemates that subsequently developed leukemia, cats that remained healthy had five-to tenfold higher (geometric mean) humoral antibody titers to the feline oncornavirus-associated cell membrane antigen. this is compatible with the application of the immunosurveillance hypothesis to the natural development of leukemia in an outbred mammalian species. | 1975 | 173019 |
| [an unusual case of dilatation of the oesophagus in a cat (author's transl)]. | 1975 | 173040 | |
| determination of subgroup-specific feline oncornavirus-neutralizing antibody. | a microneutralization assay was developed for antibody-to-subgroup-specific feline oncornaviruses. this study combines the economic advantage of a microtiter system and the quantitative focus reduction method which permits contruction of multiplicity curves for determination of virus-neutralizing titers. a twofold increase in synder-theilen feline sarcoma virus (st-fesv) on feline embryo cells decreased by approximately twofold the titer of reference goat serum prepared against kawakami-theilen ... | 1975 | 173656 |
| feline leukemia virus research- an update. | 1975 | 179729 | |
| biologic and immunologic response of cats to experimental infection with feline leukemia virus. | 1975 | 183666 | |
| the epidemiology of feline leukemia virus infection. | 1975 | 183672 | |
| comparative epidemiological aspects of naturally occurring malignant lymphoma in domestic cats and rhesus monkeys. | 1975 | 183676 | |
| seroepidemiologic testing in man for evidence of antibodies to feline leukemia virus and bovine leukemia virus. | 1975 | 183678 | |
| surface properties of mammalian c type viruses. | 1975 | 183712 | |
| prevention of the contagious spread of the feline leukemia virus between pet cats. | 1975 | 183720 | |
| treatment of feline lymphosarcoma with feline blood constituents. | 1975 | 183721 | |
| antigenic relationships between murine, feline and primate rna tumor viruses and membrane antigens of human leukemic cells. | 1975 | 183726 | |
| lymphocyte mitogen reactivity in feline leukemia virus-infected cats and identification of feline t and b lymphocytes. | 1975 | 183735 | |
| pyridoxal 5' phosphate: a selective inhibitor of oncornaviral dna polymerases. | 1976 | 183761 | |
| a case of feline infectious anemia (haemobartonellosis) with simultaneous feline leukemia virus. | 1976 | 184578 | |
| a comparison of the enzymatic responses of the dna polymerases from four rna tumor viruses. | 1976 | 184781 | |
| methylation of high-molecular-weight subunit rna of feline leukemia virus. | the high-molecular-weight subunit rna of feline leukemia virus (rickard strain) (felv-r) was analyzed for the presence of methyl groups. after purification of native 50-60s felv-r rna on nondenaturing aqueous sucrose density gradients. felv-r 28s subunit rna, doubly labeled with [14c]uridine and [methyl-3h]methionine, was isolated by centrifugation through denaturing sucrose density gradients in dimethyl sulfoxide. as calculated from their respective 3h/14c ratios. felv-r 28s rna was methylated ... | 1976 | 185408 |
| analysis of intracellular feline leukemia virus proteins. i. identification of a 60,000-dalton precursor of feline leukemia virus p30. | the synthesis and release of feline leukemia virus p30 was studied using a permanently infected feline thymus tumor cell line. disrupted cells were divided into two subcellular fractions, a cytoplasmic extract (ce) representing cellular material soluble in 0.5% np-40 and a particulate fraction (pf) insoluble in 0.5% np-40 but soluble in 0.2% deoxycholate and 0.5% np-40. intracellular feline leukemia virus p30 was isolated from infected cells by immune precipitation with antiserum to p30 and subs ... | 1976 | 185422 |
| the presence of leukaemia (lymphosarcoma) and feline leukaemia virus (felv) in cats in the netherlands. | 1976 | 185459 | |
| viruses as an etiologic factor in cancer. | 1976 | 185722 | |
| control of feline leukaemia virus infection. | 1976 | 185780 | |
| specificities of human immunoglobulins reactive with antigens in preparations of several mammalian type-c viruses. | 1976 | 185804 | |
| expression of feline type-c virus in normal and tumor tissues of the domestic cat. | tumor and normal tissues from domestic cats were examined for felv and rd-114 specific nucleic acids and proteins. virus-positive tissues showed a 100- to 200-fold higher level of felv and a 200- to 400-fold higher level of felv p30 than virus-negative tumors and normal cat tissues. in contrast, the levels of rd-114 viral rna and p30 antigen were comparable in the majority of tumorous and normal tissues examined. when the dna of these tissues was examined for felv-related sequences, the virus-po ... | 1976 | 186414 |
| natural immunity in cats to feline leukemia viral antigens. | an isotopic antiglobulin assay was developed to measure antibodies in "normal" cats to focma, a cell surface antigen associated with immunity to felv-induced tumors. the assay was shown to be specific for detecting focma antibody by several criteria including a correlation with cell membrane immunofluorescence and absorption tests. antibody to focma developed following felv infection and was expressed in heterologous species. in combination with an assay for antibody to felv p30, the major virio ... | 1976 | 186536 |
| feline oncornavirus-associated cell membrane antigen. vi. cytotoxic antibody in cats exposed to feline leukemia virus. | feline leukemia virus (felv)-infected specific pathogen-free (spf) cats, normal uninfected spf cats, and healthy cats from leukemic households were tested for antibody reactive to the feline oncornavirus-associated cell membrane antigen (focma)-containing target cell line fl-74 by microcytotoxicity and indirect membrane immunofluorescence. of the infected spf animals, 81% showed concordant reactivity for the two tests. in contrast, only 55% of the healthy cats known to be naturally exposed to fe ... | 1976 | 186623 |
| laboratory diagnosis of viral and other infectious diseases. | 1976 | 186928 | |
| feline leukemia virus infection: age-related variation in response of cats to experimental infection. | sixty-seven specific-pathogen-free cats of various ages (newborn, 2 wk, 1 mo, 2 mo, 4 mo, and 1 yr) were inoculated ip with either the rickard (r) or the kawakami-theilen (kt) strain of feline leukemia virus (felv). susceptibility to felv was judged by induction of a) felv group-specific antigens (gsa) in leukocytes, b) felv-related disease, c) antibody to feline oncornavirus-associated cell membrane antigen (focma), and d) virus-neutralizing (vn) antibody. susceptibility to felv-decreased with ... | 1976 | 187771 |
| characterization of feline t-and b-lymphocytes and identification of an experimentally induced t-cell neoplasm in the cat. | membrane markers of feline t- and b-lymphocytes were identified for further investigation of leukemogenesis in the cat. feline t-cells formed spontaneous erythrocyte rosettes with guinea pig (gpe) and rat erythrocytes (re). the receptors for gpe and re were separate entities and expressed independently on lymphoid cell membranes. the re receptor appeared to be present only on more mature or differentiated t-cells, whereas the gpe receptor reacted with a broader population that included less diff ... | 1976 | 187781 |
| lymphocyte mitogen reactivity and enumeration of circulating b- and t-cells during feline leukemia virus infection in the cat. | mitogen-induced blast transformation of peripheral blood lymphocytes and quantitative changes in circulating t- and b-cells were studied serially in cats inoculated with feline leukemia virus (felv). concanavalin a-induced blast transformation sharply declined beginning at 5 weeks post inoculation (pl) in felv-infected cats when compared to age-matched uninfected control cats. similar but less consistent changes were seen in responses to pokeweed mitogen-induced stimulation. in most infected kit ... | 1976 | 187790 |
| natural antibodies in sera from healthy humans to antigens on surfaces of type c rna viruses and cells from primates. | sera from healthy humans contained naturally occurring antibody against group- or subgroup-specific antigen on the envelope of the following type c viruses isolated from primates: gibbon ape leukemia virus, simian (woolly monkey) sarcoma virus, baboon endogenous type c virus, and putative human type c viruses [hl23v isolated from blood cells of a patient with acute myelogenous leukemia (hl23) and hel-12v from human embryonic diploid cells (cih-32)]. two sera also reacted with c57bl/6 mouse leuke ... | 1976 | 181753 |
| continuing search for the etiology of cat scratch disease. | fifty cat scratch disease patients were tested for antibodies against candidate etiological agents, with inconclusive results. future research should emphasize new viral isolation methods to discover the elusive agent. | 1976 | 182715 |
| prevention of the contagious spread of feline leukaemia virus and the development of leukaemia in pet cats. | 1976 | 183148 | |
| feline leukemia virus induced disorders in the cat. | 1976 | 183335 | |
| feline anemia. | 1976 | 183337 | |
| antigen related to mammalian type-c rna viral p30 proteins is located in renal glomeruli in human systemic lupus erythematosus. | an antigen related to mammalian type-c rna viral p30 proteins was shown by the use of anti-p30 sera and the indirect immunofluorescence method to be present in the kidneys and spleen in a fulminant fatal case of human systemic lupus erythematosus and to be located in the glomeruli, the site of active lupus diffuse glomerulonephritis. | 1976 | 174099 |
| biology of feline leukemia virus in the natural environment. | the feline leukemia virus (felv) was discovered in 1964 in a cluster of cats with lymphosarcoma. the observed clustering of cases of feline lymphosarcoma suggested that felv was an infectious agent for cats. the development of a simple immunofluorescent test for felv permitted a seroepidemiological study to be undertaken on the distribution of the virus in cats living in their natural environment. over 2000 cats were tested, and the results showed conclusively that felv is an infectious agent fo ... | 1976 | 175919 |
| humoral immune responses of cats to feline leukemia virus: comparison of responses to the major structural protein p30 and to a virus-specific cell membrane antigen (focma). | radioimmunoprecipitation was used to test cat sera for ability to bind to the purified major internal protein p30 of feline leukemia viurs (felv), to the endogenous cat virus (rd-114), and to murine leukemia virus (mulv). the data were compared with results of tests for antibody to the feline oncornavirus-associated cell membrane antigen focma and for the presence of viremia. in contrast to the general lack of free antibody to felv p30 in a random sample of healthy cats, high levels of antibody ... | 1976 | 176414 |
| hydrodynamic diameters of murine mammary, rous sarcoma, and feline leukemia rna tumor viruses: studies by laser beat frequency light-scattering spectroscopy and electron microscopy. | we have studied purified preparations of murine mammary tumor virus (mumtv), rous sarcoma virus (rsv; prague strain), and feline leukemia virus (felv) by laser beat frequency light-scattering spectroscopy, ultra-centrifugation, and electron microscopy. the laser beat frequency light-scattering spectroscopy measurements yield the light-scattering intensity, weighted diffusion coefficients. the corresponding average hydrodynamic diameters, as calculated from the diffusion coefficients by the stoke ... | 1976 | 176431 |
| antigenic activity of human urothelial tissue. | partially purified extracts from 71 human urothelial tumors and from 75 human urothelial non-tumor tissues were used as competing antigens in competition radioimmunoassay in an effort to detect the presence of 1 of the structural components of type c-ribonucleic and viruses, the p30 core protein. testing of the tissue extracts was carried out by homologous and heterologous assay systems using 125i-labeled murine (friend) and feline (rickard) p30 antigens and anti-feline and anti-murine p30 antis ... | 1976 | 176474 |
| an improved assay for feline leukaemia virus pseudotypes of murine sarcoma virus. | an assay is described for feline leukaemia virus pseudotypes of murine sarcoma virus which increased the virus titre by about 100-fold over conventional assays. the titre is independent of dilution and no secondary focus formation occurs. the assay may be used to study virus neutralization and to detect and type feline leukaemia virus in feline embryo cells by interference. | 1976 | 177726 |
| [leukemia viruses]. | 1976 | 178390 | |
| inactivation of tumor cell-associated feline oncornavirus for preparation of an infectious virus-free tumor cell immunogen. | ultraviolet (uv) and thermal methods of inactivating the oncogenic potential of c-type particle-producing feline oncornavirus-induced tumor cells were developed. the techniques were evaluated by several parameters for their use in preparation of cellular immunogens. the uv inactivation dose required to reduce the number of focus-forming units per ml by 1 log10 for fl-74 lymphoblastoid cell-associated feline leukemia virus was 44,000 ergs/sq mm, and the thermal inactivation dose required to reduc ... | 1976 | 178427 |
| fractionation of dna nucleotide transcripts from moloney sarcoma virus and isolation of sarcoma virus-specific complementary dna. | radioactive dna complementary to nucleotide sequences in moloney murine sarcoma virus (msv) and moloney leukemia virus (m-mulv) complex was made by the endogenous reverse transcriptase reaction. these virus stocks contained a threefold excess of msv over m-mulv as measured by biological assay. the complementary dna was an accurate copy of the viral rna in that 86% of 35s viral rna hybridized with complementary (cdna) dna at a 1.5 to 1 cdna-rna molar ratio. the complementary dna, of a 4-6s size, ... | 1976 | 178890 |
| letter: immunosurveillance of naturally occurring feline leukemia. | 1976 | 179140 | |
| viral diseases of cats: current concepts. | 1976 | 179185 | |
| inactivation of murine xenotropic oncornavirus by normal mouse sera is not immunoglobulin-mediated. | 1976 | 179206 | |
| therapy of neoplasia in domestic animals. | 1976 | 188328 | |
| influence of culture conditions of growth of fl-74 cells and feline oncornavirus cell membrane associated antigen production. | the fl-74 cell, a feline lymphoblastoid cell line derived from a tumor induced by leukemia virus, grows equally well in static suspension culture (plastic t-flask or silicone treated glass bottles) or in spinner culture. no growth was observed in unsiliconized glass bottles. although feline leukemia virus production was nearly the same in fl-74 grown in each of the above types of vessel, the expression of the feline oncornavirus membrane associated antigen (focma), as determined by membrane immu ... | 1976 | 172437 |
| properties of mouse leukemia viruses. x. occurrence of viral structural antigens on the cell surface as revealed by a cytotoxicity test. | 1976 | 54978 | |
| properties of mouse leukemia viruses. xi. immunoelectron microscopic studies on viral structural antigens on the cell surface. | 1976 | 54979 | |
| immune response to leukemia virus and tumor-associated antigens in cats. | cats represent an unusually valuable model for studying the role of the immune response to leukemia, lymphoma, and other mesodermal neoplasms. the agents that cause spontaneous feline leukemias, lymphomas, and fibrosarcomas, the feline leukemia and sarcoma viruses, are well characterized. a specific tumor cell membrane antigen, designated the feline oncornavirus-associated cell membrane antigen (focma) has also been described. feline leukemia and feline sarcoma viruses are antigenically indistin ... | 1976 | 56224 |
| purification and serological characterization of the major envelope glycoprotein from akr murine leukemia virus and its reactivity with autogenous immune sera from mice. | the major envelope glycoprotein (gp71) from akr murine leukemia virus (mulv) was purified and its serological reactivity with heterologous and autogenous immune mouse sera was examined. homologous and interspecies competition radioimmunoassays using antisera to rauscher-mulv gp69/71 or friend-mulv gp71 or antisera to feline leukemia virus to precipitate 125i-labeled gp71 from various mulv showed that distinct differences exist between rauscher- or friend-mulv and akr-mulv glycoproteins. characte ... | 1976 | 56459 |
| felv-related sequences in dna from a felv-free cat colony. | 1976 | 56809 | |
| isolation and characterization of an antigen of the bovine c-type virus. | by means of gel filtration and isoelectric focusing, an antigen of the bovine c-type leukemia virus was isolated in a highly purified form from extracts of infected cells. the antigen has a molecular weight of approximately 25,000 daltons and an isoelectric point of 6.4 to 6.6. in immunodiffusion experiments, the antigen forms a line of identity with an antigen extracted from highly purified bovine c-type leukemia virus by treatment with ether or triton x-100. as determined by immunodiffusion an ... | 1976 | 56993 |
| bovine leukemia virus: an exogenous rna oncogenic virus. | short-term cultures of bovine leukemic lymphocytes release virus particles with biochemical properties of rna oncogenic viruses. these particles, tentatively called bovine leukemia virus (blv), have a high molecular weight rna-reverse transcriptase complex and a density of 1.155 g/ml in sucrose solutions. molecular hybridizations between blv/[3h]cdna and several viral rnas show that blv is not related to mason-pfizer monkey virus, simian sarcoma associated virus, feline leukemia virus, or avian ... | 1976 | 57616 |
| infectious proviral dna in human cells infected with transformation-defective type c viruses. | 1976 | 57665 | |
| neutralization of homologous and heterologous oncornaviruses by antisera against the p15(e) and gp71 polypeptides of friend murine leukemia virus. | 1976 | 58469 | |
| type c viruses from kirsten sarcoma-transformed mink cells co-cultivated with primate cells and expressing p30 antigens related to feline leukemia virus. | two type c viruses with new antigenic and biological properties were isolated by co-cultivating secondary cell strains established from the kidneys of a baboon (papio papio) and a patas monkey (erythrocebus patas) with mink cells non-productively transformed by kirsten sarcoma virus. both new isolates (designated pp-1r and ep-1r) contain major structural proteins (p30) that are immunologically most closely related to the p30 proteins of feline leukemia viruses. the reverse transcriptases of both ... | 1976 | 60495 |
| endogenous type-c rna viruses of mammalian cells. | 1976 | 62589 | |
| bvr-1, a restriction locus of a type c rna virus in the feline cellular genome: identification, location, and phenotypic characterization in cat x mouse somatic cell hybrids. | somatic cell hybrids were constructed between balb/c-rag mouse cells and feline lymphoma cells by the hypoxanthine-aminopterin-thymidine selection scheme. rag cells spontaneously produce an endogenous b-tropic type c virus. cat-mouse hybrids preferentially segregate feline chromosomes and retain murine chromosomes-demonstrable by karyotypic and isozyme analyses. despite the presence of the complete mouse genome, including the viral genome, virus production was diminished to 1-5% of the levels ob ... | 1976 | 63949 |
| [feline leukosis and sarcoma viruses]. | 1976 | 64021 | |
| type c virogenes: modes of transmission and evolutionary aspects. | 1976 | 64381 | |
| bovine leukemia virus: an exogenous rna oncogenic virus? | short term cultures of bovine leukemic lymphocytes release virus particles with biochemical properties of rna oncogenic viruses. these particles, tentatively called bovine leukemia virus (blv) have a high molecular weight-reverse transcriptase complex and a density averaging 1.155 g/ml in sucrose solutions. molecular hybridizations between blv-3h cdna and several viral rnas show that blv is not related to mason-pfizer monkey virus (mpmv) simian sarcoma associated virus (ssv-1) feline leukemia vi ... | 1976 | 64382 |
| effect of feline panleukopenia virus infection on development of humoral and cellular immunity. | cats were infected with feline panleukopenia virus (fplv) at various ages pre- and post-parturition. all fetuses infected at 35 days of gestation from one queen and a single fetus infected at 45 days of gestation from a second queen had a significant delay in time of skin allograft rejection. older fetuses and newborn kittens infected with fplv did not show this delay in rejection time. adult cats infected with fplv demonstrated a significant decrease in lymphocyte responsiveness to two t cell m ... | 1976 | 782787 |
| experimental oncornavirus vaccines in the cat. | an experimental approach to the immunoprophylatic control of feline oncornavirus-mediated diseases has included induction of antivirus immunity and antibodies to the feline oncornavirus-associated membrane (tumor) antigens. a suitable model for exploring the effectiveness of killed oncornavirus vaccines in the cat has been provided by the use of feline sarcoma virus. immunization of seven pregnant queens over a 6-week period with ultraviolet light-inactivated gardner-arnstein feline sarcoma viru ... | 1976 | 943234 |
| immuno-prophylaxis and -therapy of c-type oncorna viral diseases in mice and cats. | 1977 | 202852 | |
| feline oncornavirus-associated cell membrane antigen: evidence for an immunologically crossreactive feline sarcoma virus-coded protein. | the feline oncornavirus-associated cell membrane antigen (focma) acts as a target for natural immuno-surveillance against tumor development in the cat. in the present study, mink and rat cells nonproductively transformed by feline sarcoma virus (fesv) were shown to express focma as well as 5'-terminal feline leukemia virus (felv) gag gene proteins, p15 and p12. in contrast, such cells lack detectable levels of other felv gag gene-coded proteins or the env gene product, gp70. focma, p15, and p12 ... | 1977 | 202959 |
| interspecies determinants of friend leukemia virus antigens involved in cytolysis of virus-pfoducing cells. | the cytolytic reactivity of a complex goat anti-feline leukemia virus (felv) antiserum for mouse cells (eveline) releasing large quantities of friend leukemia virus (flv) was analyzed by the sensitive [14c]nicotinamide release microcytotoxicity assay. whereas this interspecies killing reactivity could be blocked by absorption of the goat anti-felv serum with a preparation of disrupted flv, absorption with purified flv gp71, the major envelope glycoprotein, had no effect. subsequent serum absorpt ... | 1977 | 64623 |
| cells transformed by certain strains of moloney sarcoma virus contain murine p60. | it was previously demonstrated that the 60,000 dalton (p60) precursor-like polyprotein containing murine p30 was a constituent of the feline leukemia virus pseudotype of moloney sarcoma virus [m1msv(felv)]. it is now shown that p60 is detected in cells of five mammalian species transformed by m1msv, indicating that p60 is specified by this genome. moreover, little or no murine p30 is detected in the m1msv-transformed cells, suggesting that the murine group p30 antigenic reactivity of s + l- cel ... | 1977 | 65230 |