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[measured running in the overall treatment of chronic ischemic heart disease]. 2005538895
[epidemiological studies on systemic lupus erythematosus(sle) (1)]. 20051169520
[a new flexible water-equivalent material (author's transl)]. 20051064001
properties of the thermostable glutamate dehydrogenase of the mesophilic anaerobe peptostreptoccus asaccharolyticus purified by a novel method after over-expression in an escherichia coli host.peptostreptococcus asaccharolyticus glutamate dehydrogenase (l-glutamate: nad+ oxidoreductase (deaminating); ec 1.4.1.2) overexpressed in escherichia coli has been purified by two new methods. enzyme made by the first method showed remarkable thermophilicity, with a temperature optimum of 60 degrees c, and also thermostability, which suggested the second, simpler method, incorporating a heat step. this produced 94 mg of homogeneous protein per litre culture medium. the basic kinetic parameters f ...200515727821
in vitro activities of dalbavancin and 12 other agents against 329 aerobic and anaerobic gram-positive isolates recovered from diabetic foot infections.tests of dalbavancin's in vitro activity against 209 aerobic and 120 anaerobic isolates from pretreatment diabetic foot infections showed an mic(90) of < or =0.125 microg/ml against methicillin-susceptible staphylococcus aureus (mssa), methicillin-resistant s. aureus (mrsa), and 120 anaerobes (clostridium perfringens, other clostridia, peptoniphilus asaccharolyticus, finegoldia magna, and anaerococcus prevotii), compared to respective mic(90)s for mssa and mrsa of 0.5 and 1 microg/ml for vancomy ...200616870792
[hypertension detection and follow-up program(hdfp)]. 20061635190
doppler investigation of uteroplacental blood flow resistance in the second trimester: a screening study for pre-eclampsia and intrauterine growth retardation. 20061472202
costs of pharmaceutical care: can the profession do anything?to review some of the factors that influence the cost of pharmaceuticals and the delivery of pharmaceutical care as well as some possible measures for decreasing these costs.20061482817
discomfort and pain during mammography: description, prediction, and prevention.to identify the nature of pain and discomfort experienced during mammography and how it can be ameliorated.20061392955
antigen-receptor complex stimulation triggers protein kinase c-dependent cd11a/cd18-cytoskeleton association in t lymphocytes.although it is well accepted that intercellular adhesion involving the cd11a/cd18 (lfa-1) complex is critical in a wide array of t cell-dependent processes, recent demonstrations of an lfa-1 high avidity state, induced by triggering the t cell receptor (tcr) complex, has raised questions about the intracellular signals generated and molecular events leading to effective cell coupling, as well as their orderly sequence. in this study, we assessed the effects of t cell activation on the actin-base ...20061346786
functional analysis of the -300 region of maize zein genes.a 43 bp fragment containing the -300 region upstream control element common to the endosperm expressed zein genes of zea mays l. has been analyzed by in vivo and in vitro techniques. transient transformation studies with protoplasts from a maize endosperm culture indicate that the element positively affects camv 35s promoter-driven gene expression, and that this effect is both orientation- and position-dependent. band-shift and southwestern blotting experiments demonstrate that the element is sp ...20061538693
sense of coherence, self-esteem, depression and hopelessness as correlates of reattempting suicide.sense of coherence (soc) has been proposed as a psychological factor that predicts good health and positive adjustment. the three components of soc: manageability, comprehensibility and meaning were assessed together with depression, hopelessness and self-esteem as factors predicting future suicidal ideation and behaviour in parasuicides. one hundred and fifty hospitalized parasuicides were evaluated on these measures and followed up after six months to determine their current level of suicidal ...20061393158
in vitro activity of ceftobiprole against aerobic and anaerobic strains isolated from diabetic foot infections.against 443 aerobic and anaerobic bacteria isolated from diabetic foot infections, ceftobiprole mics (microg/ml) at which 90% of the isolates tested were inhibited were as follows: methicillin-resistant staphylococcus aureus, 1; methicillin-susceptible s. aureus and staphylococcus lugdunensis, 0.5; anaerococcus prevotii, 0.125; finegoldia magna, 0.5; peptoniphilus asaccharolyticus, 1; peptostreptococcus anaerobius, 4; escherichia coli and enterobacter species, 0.125; klebsiella species, 2; and p ...200616982780
mandatory testing? 20061426457
[an epidemiology of hypertension in japanese]. 20061635191
development of 16s rrna-based probes for the identification of gram-positive anaerobic cocci isolated from human clinical specimens.fluorescent probes targeted at 16s rrna were designed for peptostreptococcus anaerobius and peptostreptococcus stomatis (pana134), parvimonas micra (pamic1435), finegoldia magna (fmag1250), peptoniphilus asaccharolyticus (pnasa1254), peptoniphilus ivorii (pnivo731), peptoniphilus harei (pnhar1466), anaerococcus vaginalis (avag1280) and anaerococcus lactolyticus (alac1438), based on the 16s rrna sequences of reference strains and 88 randomly chosen clinical isolates. these strains were also used ...200717714522
in the aftermath: health care in kuwait city. 20071865865
validation of the five minute speech sample in measuring expressed emotion.the relationship of the five minute speech sample (fmss) to the camberwell family interview and its coding system were evaluated. the camberwell family interview and the fmss were administered to twenty-three relatives of patients diagnosed with schizophrenia. overall, the results supported the utility of the fmss and its coding system as a brief screening device for measuring expressed emotion.20071868424
chemotherapy-related hemolytic-uremic syndrome after the treatment of head and neck cancer. a case report.a 62-year-old woman who was being treated for squamous cell carcinoma of the head and neck developed a chemotherapy-related hemolytic-uremic syndrome during the second cycle of neoadjuvant chemotherapy consisting of cisplatin, bleomycin, and methotrexate. though the syndrome was suspected early, attempts at reversing the hematologic and renal abnormalities were unsuccessful. at postmortem examination, the characteristic microvascular lesions of the hemolytic-uremic syndrome were found in the kid ...20072224786
insulin secretagogues induce ca(2+)-like changes in cytoplasmic mg2+ in pancreatic beta-cells.the effects of insulin secretagogues on the cytoplasmic mg2+ concentration ([mg2+]i) of pancreatic beta-cells were studied in suspensions and in individual beta-cells using dual-wavelength fluorometry and the indicator mag-fura-2. average [mg2+]i was in the 800-900 microm range in a medium containing 3 mm glucose. when the sugar concentration was raised to 20 mm, the cells reacted with an initial lowering of [mg2+]i followed by an increase. the sugar apparently also stimulated leakage of the mg2 ...20072223873
insulin secretagogues induce ca(2+)-like changes in cytoplasmic mg2+ in pancreatic beta-cells.the effects of insulin secretagogues on the cytoplasmic mg2+ concentration ([mg2+]i) of pancreatic beta-cells were studied in suspensions and in individual beta-cells using dual-wavelength fluorometry and the indicator mag-fura-2. average [mg2+]i was in the 800-900 microm range in a medium containing 3 mm glucose. when the sugar concentration was raised to 20 mm, the cells reacted with an initial lowering of [mg2+]i followed by an increase. the sugar apparently also stimulated leakage of the mg2 ...20072223873
counsel and care. 20071933094
body mass index variations: centiles from birth to 87 years.this report provides body mass index (weight/height2) values for the french population from birth to the age of 87 years. bmi curves increase during the first year, decrease until the age of 6, increase again up to 65 years and decrease thereafter. these variations reflect the total changes of fat body mass during life. the 50th centile values of wt/ht2 at the ages of 20, 40, 60, 80 years are 21.5, 24.6, 25.4, 24.4 kg/m2 for men and 20.6, 22.6, 24.1, 23.4 kg/m2 for women. the values for the 3rd, ...20071855495
probing the determinants of coenzyme specificity in peptostreptococcus asaccharolyticus glutamate dehydrogenase by site-directed mutagenesis.glutamate dehydrogenase (ec 1.4.1.2-4) from peptostreptococcus asaccharolyticus has a strong preference for nadh over nadph as a coenzyme, over 1000-fold in terms of kcat/km values. sequence alignments across the wider family of nad(p)-dependent dehydrogenases might suggest that this preference is mainly due to a negatively charged glutamate at position 243 (e243) in the adenine ribose-binding pocket. we have examined the possibility of altering coenzyme specificity of the peptostreptococcus enz ...200717850332
activities of four frog skin-derived antimicrobial peptides (temporin-1dra, temporin-1va and the melittin-related peptides ar-23 and rv-23) against anaerobic bacteria.the activities of two antimicrobial peptides belonging to the temporin family (temporin-1dra from rana draytonii and temporin-1va from rana virgatipes) and two peptides with structural similarity to the bee venom peptide melittin (ar-23 from rana tagoi and rv-23 from r. draytonii) were evaluated against a range of reference strains and clinical isolates of anaerobic bacteria. these peptides were selected because they show broad-spectrum growth inhibitory activity against reference strains of sev ...200717196372
inter-observer variability in the measurement of body composition.the inter-observer variation in simple bedside assessments of body composition has been evaluated in 12 healthy adult subjects (6 male and 6 female) by 6 observers. systematic bias between observers was found to be evident in each of the basic measurements (except height) and in each of the estimates of body composition (except those derived from weight and height alone). the largest residual coefficients of variation (rcv) for the basic measurements were found for skinfold thickness (11-18 per ...20071855499
risk factors in chronic obstructive pulmonary malfunction and "chronic bronchitis" symptoms in beijing district: a joint study between japan and china.a cross sectional study of risk factors in respiratory diseases was carried out in august 1986, in beijing, china. inhabitants greater than or equal to 40 years old were selected at random from a rural area, a residential area and an industrial area, using a two stage sampling method. the analysis presented here is based on the sample population of adults who (1) were prepared to be interviewed, using the british medical research council's questionnaire translated into chinese (n = 3423) and (2) ...20082592885
fifty hours for the poor? 20082612144
[mortality in accidents in spain: contrast of various statistical series].the data on deaths due to accidents in spain during the period 1975-79 is analyzed and compared according to three routine sources of information: death certificates, codified, tabulated and presented by the national statistics institute (ine): traffic accident reports from the directorate general of traffic (dgt): and work-related accidents according to reports drawn up by the national institute of job health and safety. the comparison reveals that the data from death certificates are not usefu ...20082519491
the risks and benefits of low-dose cotrimoxazole prophylaxis for pneumocystis pneumonia in renal transplantation. 20082646786
[analysis of the nursing factors responsible for expanding the sphere of daily activities of patients with parkinson's disease]. 20082612141
[analysis of the nursing factors responsible for expanding the sphere of daily activities of patients with parkinson's disease]. 20082612141
quantitative survival of aerobic and anaerobic microorganisms in port-a-cul and copan transport systems.transport media should preserve the viability and stability of microorganisms in clinical specimens. in this study, the port-a-cul transport system and the copan transport system without charcoal, both designed to preserve anaerobes, were evaluated. dacron swabs were inoculated with two combinations of facultative and anaerobic organisms typically found in vaginal swab samples. combination i contained candida albicans, escherichia coli, enterococcus spp., group b streptococci, lactobacillus cris ...200818579722
increased formation of dna adducts in cultured fibroblasts of patients with aplastic anemia after in vitro incubation with benzo(a)pyrene.in inbred mice strain dba/2, genetically controlled differences in aryl hydrocarbon hydroxylase (ahh) activity have been demonstrated that predispose to aplastic anemia. to test the hypothesis of a similar mechanism in humans, we studied the formation of benzo(a)pyrene dna adducts and water-soluble metabolites in skin fibroblasts from eight patients with aplastic anemia and eight normal controls. the ratio of water-soluble metabolites and dna adducts was 46.5 +/- 16.6 in patients and was signifi ...20082289825
[precancerous lesions of the colon and rectum].adenomatous polyp, adenomatosis coli and dysplasia in the inflammatory bowel disease are noted as precancerous lesions. 1) adenomatous polyps are easily found by colonoscopy as protruded lesions and diagnosed by histopathological study. 2) adenomatosis coli is easily diagnosed by barium enema and colonoscopy. adenomatosis coli is accompanied with cancer frequently. as soon as adenomatosis coli is detected, we recommend surgery. ira (total colectomy and ileorectal anastomosis) is mainly undertake ...20082730060
gut size and the digestion of fibrous diets by tetraonid birds.a series of diets containing different proportions of heather was fed to red grouse. heather is the bird's main natural food and contains much fiber; the rest of each diet was a relatively low-fiber, grain-based formulation. with increasing heather and associated fiber contents, food intake increased and overall digestibility of heather was only 9.4%, but, when heather was eaten as the sole food by wild red grouse, its digestibility was 46%. adaptations to diets containing more heather included ...20082575129
life in the fast lane. 20092771765
[the radiologic picture of multiple adenomatosis of the colon: correlation with the natural history]. 20092812461
anaerosphaera aminiphila gen. nov., sp. nov., a glutamate-degrading, gram-positive anaerobic coccus isolated from a methanogenic reactor treating cattle waste.a strictly anaerobic, mesophilic and aminolytic strain (wn036(t)) was isolated from a methanogenic reactor treating waste from cattle farms. cells were gram-positive cocci, often occurred in pairs and were non-motile. although spore formation was not confirmed by microscopic observation of cells, the strain produced thermotolerant cells. the optimum temperature for growth was 35-37 degrees c and the optimum ph was 6.7. oxidase, catalase and nitrate-reducing activities were negative. the novel st ...200919643871
rationalism versus irrationalism in the care of the sick: science versus the absurd. 20092687653
[the radiologic picture of multiple adenomatosis of the colon: correlation with the natural history]. 20092812461
a century of change in neurosurgery at johns hopkins: 1889-1989.neurosurgical admissions to the johns hopkins hospital during the first year of its existence, the first and last years of harvey cushing's practice, the last years of walter dandy's practice, the last years of earl walker's tenure, and the current neurosurgical case load are reviewed. sixteen patients with neurosurgical problems were admitted during the first year of the hospital's existence. in the first year of harvey cushing's staff appointment, 38 neurosurgical patients were admitted. infec ...20092681565
closed intramedullary nailing of diaphyseal fractures of the femur. problems related to anatomical variations of the greater trochanter.an examination of the radiographs of 100 normal femurs revealed an anatomical variation consisting of lateralization of the trochanteric mass in relation to the femoral diaphysis. this involves disalignment of the apex of the greater trochanter in relation to the medullary canal, with consequent complications during closed intramedullary nailing such as varus of the fracture segments, valgus of the nail, fracture of the medial cortex. since becoming aware of this anatomical variation and its pos ...20092737894
[cesarean section in current obstetrics]. 20102935019
[the department of health and social services: plan of action against aids: phase ii]. 20102927784
[liver disease in toxic oil syndrome. clinical and enzymatic course].one-hundred and fifty-nine patients intoxicated with adulterated oil in the province of salamanca, spain, were followed-up for 2 years from the onset of the syndrome, in 1981. four alcoholic patients were excluded from the study. in the remaining 155 patients the liver involvement at the onset took different forms. it was acute in 12 (7%), with jaundice and/or hepatomegaly associated with cytolysis and/or cholestasis; 21 patients (13%) had evidence of cytolysis and/or cholestasis without clinica ...20102864683
crystallization and preliminary structural analyses of glutamate dehydrogenase from peptoniphilus asaccharolyticus.glutamate dehydrogenase (ec 1.4.1.2-4) from peptoniphilus asaccharolyticus has been expressed as a selenomethionine-derivatized recombinant protein and diffraction-quality crystals have been grown that are suitable for structure determination. preliminary structural analyses indicate that the protein assembles as a homohexameric enzyme complex in solution, similar to other bacterial and mammalian enzymes to which its sequence identity varies between 25 and 40%. the structure will provide insight ...201020445250
crystal structure of nad(+)-dependent peptoniphilus asaccharolyticus glutamate dehydrogenase reveals determinants of cofactor specificity.glutamate dehydrogenases (ec 1.4.1.2-4) catalyse the oxidative deamination of l-glutamate to α-ketoglutarate using nad(p) as a cofactor. the bacterial enzymes are hexamers and each polypeptide consists of an n-terminal substrate-binding (domain i) followed by a c-terminal cofactor-binding segment (domain ii). the reaction takes place at the junction of the two domains, which move as rigid bodies and are presumed to narrow the cleft during catalysis. distinct signature sequences in the nucleotide ...201122068154
antiimmunoglobulin-treated b cells respond to a b cell differentiation factor for igg1.we have determined whether b cells previously activated by anti-ig (anti-ig blasts) are responsive to lymphokines that induce isotype switching. culture of anti-ig blasts with a mixture of lymphokines, including bsf-1, resulted in marked secretion of igm and igg1, but not other igg isotypes. the igg1 response of anti-ig blasts to lymphokines was 13-fold greater than was observed with splenic b cells. b cell blasts induced by 8-mercaptoguanosine or dextran sulfate did not secrete high levels of a ...20113088197
gas gangrene: a cautionary tale. 20113133027
mistaken identity of peptoniphilus asaccharolyticus. 201121248090
anti-anaerobic activity of serum from patients treated with tigecycline for skin/soft tissue infections.to gain additional data concerning the anti-anaerobic activity of tigecycline in serum, we analyzed blood samples from six patients with a complicated skin/soft tissue infection who were receiving iv tigecycline 50 mg every 12 h. venous blood samples were obtained after multiple doses of tigecycline at 1, 6 and 12 h after the initiation of a 1 h iv infusion. sera from these samples were tested to determine serum inhibitory and bactericidal activity over time against 4 anaerobic bacteria (bactero ...201121376823
[reduction of ventricular tachycardia by programmed electric stimulation. clinical implications].the mode of termination by programmed electrical stimulation of sustained ventricular tachycardia (vt) (more than 30 seconds) and induced by stimulation was investigated in 33 patients. in 27 patients (82%) programmed stimulation was possible because vt did not require an immediate electric shock or did not terminate spontaneously, but constant reduction of vt was obtained with one extrasystole in only 1 patient (3%), with two extrasystoles in 5 patients (15%) and by overdrive stimulation in 12 ...20113122686
deficiency of eosinophil peroxidase detected by automated cytochemistry. 20113122494
more about determination of n-acetyl-beta-d-glucosaminidase activity in urine without pretreatment of samples. 20123370783
optimal bandpass filters for time-domain analysis of the signal-averaged electrocardiogram.the optimal bandpass filter for signal averaging of the surface qrs complex to detect late potentials is undefined. a study was conducted in 87 patients; 25 (mean age 34 +/- 10 years) were normal (group i), 29 (60 +/- 20 years) had organic heart disease without ventricular tachycardia (group ii) and 33 (62 +/- 15 years) had sustained ventricular tachycardia (group iii). in all patients signal-averaged electrocardiography (200 beats) was performed using a sharp, bidirectional filter and data anal ...20123318369
energy-dependent imaging in digital radiography: a review on acquisition, processing and display techniques. 20123540231
energy-dependent imaging in digital radiography: a review on acquisition, processing and display techniques. 20123540231
pneumococcal meningitis and sepsis. 20123352264
effect of renal allograft dysfunction upon cyclosporine trough levels in host blood.cyclosporine (csa) dose adjustment after renal transplantation is generally based on serum, plasma, or whole-blood trough level values. in the face of increased levels, the dosage is reduced in order to prevent csa-induced nephrotoxicity. there is a paucity of data, however, on the kinetics of csa in association with dysfunction of the transplanted kidney. this study documents dramatic rises in serum cyclosporine trough levels at the time of rejection crises, as well as following periods of noni ...20133907030
liability for generic substitution. 20133809065
a mathematical model of continuous arteriovenous hemofiltration predicts performance. 20133675960
os calcis osteotomy in the management of deformities of the hindfoot in spinal dysraphism.the results of 52 primary os calcis osteotomies in 44 patients with spinal dysraphism are reviewed. there were 42 varus hindfoot deformities and ten valgus hindfoot deformities. the results indicate that the operation is simple and uncomplicated, but over a mean 5.8 year follow-up for the varus feet and 6.5 years for the valgus feet, over 50% of the feet developed either a moderate or severe recurrence of deformity. os calcis osteotomy appeared from this series to be a moderately successful inte ...20133811619
asymptomatic microhematuria and urologic disease. a population-based study.asymptomatic microhematuria is a common finding, occurring in 13% of adult men and postmenopausal women in rochester, minn. previous recommendations to perform cystoscopic and excretory urographic examinations on all patients with this finding were based on findings in referred patients. in the present population-based study, the frequency of serious urologic disease in patients with asymptomatic microhematuria was 2.3%; only 0.5% had bladder or renal cell carcinoma. urologic malignant lesions o ...20133723707
significance of parathyroid hormone (pth) radioimmunoassay in the diagnosis of primary hyperparathyroidism: an experience based on 63 surgically proven cases.the significance of pth-radioimmunoassay was assessed in 63 surgically proven cases of primary hyperparathyroidism. to detect hyperparathyroidism, an increase in the free serum ca index, [1-(8 x alb + 2 x glb + 3)/100] x ca, has the highest predictive value (100%) for a positive test but a low predictive value (11.8%) for a negative test. it was necessary to improve the criteria to rule out the diagnosis of hyperparathyroidism. we therefore carried out a pth radioimmunoassay employing kits made ...20133622392
[studies on the chemical constituents of saussurea involucrata]. 20133577789
quality monitoring in nursing homes. 20133668179
teniposide is not effective in chronic lymphocytic leukemia.teniposide has been evaluated in a phase ii clinical trial in chronic lymphocytic leukemia (cll). among 16 consecutive patients with cll entered in the study and treated with teniposide, 100 mg/m2 weekly, no objective response was observed. toxicity was generally mild and mainly hematologic. teniposide at this dosage and schedule is an inactive drug in cll.20133632912
[reconstructive plastic surgery of the humeral condyles following removal of endoprostheses of the elbow versus arthrodesis].the condyles of the elbow are of utmost importance for the stability of this joint. this is particularly evident in cases where elbow prostheses had to be removed because of loosening or infection and where the condyles had been deliberately resected at the primary operation. in order to obtain a functional elbow with sufficient stability and mobility after removal of the prostheses, we can reconstruct the condyles by means of a large autologous bone graft, which we take from the midpart of the ...20133658417
[clinical value of the time of formation of extrasystoles]. 20144187742
reactivity of lymphoid cells from mice humorally tolerant to histocompatibility antigens. 20144148456
lesser omental thickness in normal children: baseline for detection of portal hypertension.the lesser omentum between the left lobe of the liver and the aorta at the level of the celiac axis harbors the left gastric vein and artery, lymphatics, nerves, and some fatty tissue. in one study, it was found to be thickened in most of 50 children with portal hypertension, but normal values were not established. lesser omental thickness was measured in 150 children without systemic, liver, or renal disease, and it was found that it did not exceed 1.7 times the diameter of the aorta at the sam ...20143898783
[early diagnosis and therapy of cerebral motor disorders in childhood. a. postural reflexes in developmental kinesiology. i. normal developmental stages]. 20144263429
[importance of studying the sputum of pneumonia and bronchitis patients]. 20144002152
perceived voice quality disorders in down's syndrome children. 20144272968
insensible water loss. the inter-subject variation related to skin temperature, forearm circumference and sweat gland activity. 20154665981
chronic sclerosing nonsuppurative osteomyelitis. 20154510499
[a case of mucoviscidosis with myocardial involvement]. 20154657342
recurrent calcific perarthritis involving multiple sites. 20154716279
[iatrogenic radiation sickness]. 20154512267
[analysis of steroids in a 4 1/2-year-old boy with precocious puberty caused by adrenal gland carcinoma]. 20154457768
accomplishments of a salaried blood donor recruiter in a municipal hospital. 20154411811
the influence of industrial medicine on economic geography. 20154565477
[ovarian vein syndrome]. 20154704157
[editorial: life span and life quality]. 20154846704
[editorial: life span and life quality]. 20154846704
[treatment of severe spastic forms of bronchitis with nitrogen mustard]. 20164840193
[managment of postoperative imbalance of protein metabolism]. 20164960475
[legal aspects of adoption]. 20165048008
700 total hip replacements. experience with 6 types. 20164754204
hepatolenticular degeneration (wilson's disease) and rickets in children. 20164787044
[aleksandr vladimirovich kachakhidze]. 20164948920
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