Publications

in vitro activity of sodium fusidate against anaerobic bacteria.	the microtiter broth dilution method was employed to determine the in vitro susceptibility of 525 recent clinical isolates of anaerobic bacteria to sodium fusidate. the minimal inhibitory concentrations of sodium fusidate ranged from </=0.06 to 1.0 mug/ml for 155 strains of anaerobic gram-positive rods and 130 strains of anaerobic gram-positive cocci. minimal inhibitory concentrations ranging from </=0.06 to 32 mug/ml were observed for 240 strains of anaerobic gram-negative rods. among the latte ...	1979	485124
an outbreak of fusiformis necrophorus infection in orissa.		1979	489120
[combined experimental exposure to subsonics and a superhigh frequency electromagnetic field].		1979	499821
primary anaerobic peritonitis.		1979	519225
pathogenic synergism between treponema hyodysenteriae and other selected anaerobes in gnotobiotic pigs.	gnotobiotic pigs were orally exposed to various anaerobes at 6 to 9 days of age and similarly inoculated with treponema hyodysenteriae b204 3 to 6 days later. watery diarrhea and fecal excretion of large quantities of mucus and some fibrin clots were observed 4 to 20 days after inoculation with b204 if other anaerobes were present. colonic lesions characteristic of swine dysentery were observed when b204 was present with fusobacterium necrophorum, three strains of bacteroides vulgatus, a clostri ...	1979	528047
comparison of the metabolism of 2,4-toluenediamine in rats and mice.	the excretion, distribution, and metabolism of 2,4-toluenediamine (tda) have been compared in rats and mice. the elimination of tda metabolites into urine was faster and more complete in mice than in rats. however, the feces of rats accounted for a greater percentage of the dose in rats than in mice. the distribution of metabolites in tissues were considerably lower in mice than in rats. the major urinary metabolites observed in the rat were 4-acetylamino-2-aminotoluene, 2,4-diacetylaminotoluene ...	1979	547012
the in vitro cytotoxicity of native and modified trichloroacetic acid-extracted antigens from fusobacterium necrophorum for mouse peritoneal macrophages.		1979	548206
a modified tube method for the cultivation and enumeration of anaerobic bacteria.	a new type of tube (the lee tube) has been developed for use in the cultivation and enumeration of obligate anaerobes. the lee tube is a double-walled, screw-capped tube which allows the formation of a thin cylinder of agar medium between the two walls. anaerobiosis is achieved through deoxygenation of the deep cylinder of agar during sterilization, a minimum of head space, and use of a reducing agent to absorb oxygen introduced during the inoculation procedure. for several species of clostridiu ...	1979	396020
attempt to detect bovine antibody against fusobacterium necrophorum by the agar gel double diffusion test.		1979	108443
identification of new cell surface markers in man: the problem of immunogenicity.		1979	313101
[vladimir levanovich menabde (on his 80th birthday)].		1979	352807
teaching the teachers.		1979	243225
the carbon dioxide requirements of anaerobic bacteria.	some clinically significant anaerobic bacteria were incubated in pure culture in anaerobic jars containing a range of atmospheric concentrations of co2. growth of clostridium perfringens, c. sporogenes and c. septicum was independent of the amount of co2. small supplements of co2 (0.25%) allowed good growth of the majority of anaerobes studied--an observation contrary to established teaching. the exceptions were fusobacterium necrophorum which showed an absolute requirement for co2 of at least 1 ...	1980	6107383
modulation of the rats' immune status by monoassociation with anaerobic bacteria.	the capacity of a pure culture of anaerobic intestinal bacteria to influence the host's cellular and humoral immune systems was investigated with germfree, monoassociated, and conventionally reared rats. monoassociation of germfree rats with bacteroides fragilis stimulated the production of serum gamma globulin, agglutinating antibodies, and an apparent igg (immunoelectrophoresis) band. a comparison of the in vitro blastogenic potential of lymphocytes (spleen cells and mesenteric lymph node cell ...	1980	6161685
[antibacterial activity of cefoperazone against anaerobic bacteria (author's transl)].	the following results were obtained from the comparison of cefoperazone (cpz) with cefazolin (cez), cephalothin (cet) and cefoxitin (cfx) in respect to their antibacterial action against anaerobic bacteria: 1) cpz showed an antibacterial spectrum which was comparable to those of the known antibiotics, cez, cet and cfx. cpz was particularly effective against anaerobic gram-positive bacteria. 2) cpz showed a distribution of susceptibility against clinically isolated strains which was comparable to ...	1980	6454011
[severe meningitis caused by an anaerobic bacterium].		1980	7220035
[foot rot infection in mufflons].		1980	7348904
gastrointestinal ecology and histology of rats monoassociated with anaerobic bacteria.	pure cultures of anaerobic bacteria colonized the gastrointestinal tracts of germfree rats and induced an increase in the cellularity of intestinal tissue.	1980	7356318
metastatic complications of fusobacterium necrophorum sepsis. two cases of lemierre's postanginal septicemia.	we have recently encountered two instances of septicemia due to fusobacterium necrophorum in adolescents. the presence of severe exudative pharyngitis in both patients pointed to the upper respiratory tract as the probable portal of entry. in one case, metastatic infection was manifested by multiple septic pulmonary emboli with associated pleural effusions. in the other case, diffuse encephalopathy and septic arthritis of the left shoulder and hip occurred. unilateral neck pain, persistent bacte ...	1980	7369198
fatty acids and neutral sugars present in lipopolysaccharides isolated from fusobacterium species.	lipopolysaccharides (lps) extracted from cells of fusobacterium necrophorum, f. mortiferum, f. gonidiaformans. varium and single strains of f. naviforme and f. russi were analysed for sugars and fatty acids. all preparations contained a monosaccharide tentatively identified as l-glycero-d-mannoheptose, but showed variation with respect to the presence of glucose, galactose, rhamnose and another heptose isomer, tentatively identified as l-glycero-d-mannoheptose. l-glycero-d-mannoheptose was a mon ...	1980	7376878
effect of temperature, humidity and exposure to oxygen on the survival of anaerobic bacteria.	the relative effect of humidity, temperature and exposure to oxygen on the survival of 11 strains of bacteriodes spp., fusobacterium necrophorum, eubacterium lentum, clostridium ramosum, peptococcus asaccharolyticus and peptostreptococcus anaerobius was evaluated. suspensions of the test strains were applied to membrane filters either in empty sterile petri dishes or on plates of non-nutrient agar to provide dry or moist conditions. the filters were stored aerobically or anaerobically in an atmo ...	1980	7431377
cryptogenic hepatic abscess in two uncompromised children.	a pre-mortem diagnosis of cryptogenic liver abscess in children is rare, but this diagnosis must be considered in the evaluation for pyrexia of unknown origin. two previously healthy children were suspected of harboring liver abscesses. radioisotopic, sonographic, and angiographic evidence supported the clinical diagnosis. operative drainage was performed in each case. no source for either abscess was found and no cause established. anaerobic bacteria, microaerophilic streptococcus and fusobacte ...	1980	7441460
primary meningitis caused by bacteroides fragilis and fusobacterium necrophorum.	a fatal case of meningitis due to bacteroides fragilis and fusobacterium necrophorum is reported. this appears to be the first case in which meningitis due to these organisms was not secondary to a disease elsewhere in the body. the organisms are difficult to culture and strict anaerobic methods should be used whenever they are suspected. intravenous metronidazole is probably the antibiotic of choice.	1980	7443597
the circulatory effects of an acute infusion of anaerobes in a rabbit model.	results of this study show that an acute infusion of bacteroides fragilis into a rabbit model is associated with a transitory and minimal lowering of mean arterial pressure. peak left ventricular systolic pressure and its first derivative decreased significantly, but these abnormalities lasted for less than three minutes. by contrast, an infusion of fusobacterium necrophorum is associated with a profound depression of mean arterial pressure, left ventricular systolic pressure and its first deriv ...	1980	7444724
fusobacteremia in a calf with necrotic stomatitis, enteritis and granulocytopenia.	this case of fusobacteremia appears to be identical to an interesting and unusual syndrome previously reported. we wish to bring the syndrome to the attention of others who may be able to elucidate the etiology further. because hematological examinations are frequently not done on calves, this condition may be more common than reports suggest. perhaps others who observe this syndrome in calves may be able to investigate the role of other agents such as viruses or mycotoxins. experimental work ma ...	1981	7248893
fatal peritonitis following iud-associated salpingitis.	previous reports have implicated the dalkon shield intrauterine device (iud) in septic second trimester abortion and maternal death from sepsis. in the case reported here, fusobacterium necrophorum, a rarely pathogenic vaginal anaerobe, gained access to the uterus in a woman wearing a dalkon shield and caused acute parametritis, overwhelming peritonitis, systemic sepsis, and death. it is well known that iuds can contribute to the development of serious pelvic infections, and in this case it is p ...	1981	7266960
physiological and biochemical characteristics of fusobacterium necrophorum biovar a and biovar b strains and their deoxyribonucleic acid homology.		1981	7289336
fatty acids of fusobacterium species: taxonomic implications.	fatty acids of fusobacterium species were examined by gas-liquid chromatography. fusobacterium nucleatum, f. necrophorum, f. mortiferum, f. gonidiaformans and f. varium showed similar patterns, characterized by the presence of 3-hydroxytetradecanoate, n-tetradecanoate, hexadecenoate, n-hexadeconoate, ocadecenoate, n-octadecanoate and a component having the properties of octadecadienoate. fusobacterium nucleatum contained 3-hydroxyhexadecanoate as a distinctive character. simpler fatty acid patte ...	1981	7320695
necrotic laryngitis in a calf.		1981	7329388
[o.r.l. infections and craniofacial thrombophlebitis (author's transl].		1981	7336050
liver abscess production in mice by intraportal injection of fusobacterium necrophorum biovar a strain.		1981	7343698
premature labor. ii. bacterial sources of phospholipase.	human term labor is thought to be initiated by amniotic and chorionic phospholipase a2, an enzyme that liberates arachidonic acid esters from the phospholipids of these membranes, leading to the synthesis of prostaglandins by the placental membranes. the striking association of premature labor with intrauterine infection or contamination, urinary tract infection, and early neonatal sepsis led us to study the microorganisms present in these infections for phospholipase a2 activity. activity was f ...	1981	7017516
gram-negative anaerobic bacilli: their role in infection and patterns of susceptibility to antimicrobial agents. ii. little-known fusobacterium species and miscellaneous genera.	twenty infrequently reported species of gram-negative anaerobic bacilli other than fusobacterium nucleatum, fusobacterium necrophorum, and members of the genus bacteroides were studied with regard to their role in infection and their susceptibility to antimicrobial agents. in addition, the literature regarding the recovery of these organisms from both the normal flora and infections of humans was reviewed. during a six-year period at the wadsworth clinical anaerobic bacteriology research laborat ...	1981	7025153
new medium selective for fusobacterium species and differential for fusobacterium necrophorum.	fusobacterium egg yolk agar is a new medium selective for fusobacterium species and differential for fusobacterium necrophorum. the medium is a brucella agar base (difco laboratories, detroit, mich.) containing vancomycin, neomycin, josamycin, and egg yolk. all species of fusobacteria grew with only minimal inhibition. the mean log difference in counts between fusobacterium egg yolk agar and control media for 30 strains of seven species of fusobacteria was 0.1922. f. necrophorum typically showed ...	1981	7194883
bony defects in dried bantu mandibles.	forty-three dried south african bantu mandibles were examined visually and radiographically for the frequencies of occurrence of apical defects, bifurcation involvements, dehiscences, and fenestrations. statistical evaluation of the data revealed no significant discrepancy between the visual and radiographic findings.	1981	273856
fusobacterium necrophorum septicemia following oropharyngeal infection.	fusobacterium necrophorum septicemia developed in five patients after an oropharyngeal infection. four patients had sore throat or neck pain, and two had findings of jugular vein septic thrombophlebitis. metastatic abscesses, including embolic pneumonia, empyema, septic arthritis, and osteomyelitis, also occurred. four patients recovered and one died. proper treatment requires recognition of the oropharyngeal source of the septicemia and its differentiation from endocarditis. antibiotic therapy ...	1982	6955528
induction of immunologic memory by a lipopolysaccharide-protein complex isolated from fusobacterium necrophorum: cellular response.	the ability of a lipopolysaccharide protein (lps-p) complex extracted from fusobacterium necrophorum to establish immunologic memory in balb/c mice splenocytes was demonstrated. the lps-p molecule differed from the phenol water-extracted lps because it contained approximately 12% protein. initial experiments showed that primary and secondary spleen plaque-forming cell (pfc) responses to iv or im injections of lps-p were highly dose-dependent. suitable primary doses stimulated significant (p less ...	1982	7046528
vesicouterine fistula caused by fusobacterium necrophorum.		1982	7054335
hematogenous osteomyelitis caused by fusobacterium necrophorum in a calf.		1982	7085473
comparative in vitro leukotoxin production of three bovine strains of fusobacterium necrophorum.	the in vitro leukotoxic activity of 3 bovine isolates of fusobacterium necrophorum which varied in pathogenicity were compared. monolayers of mouse peritoneal macrophages were exposed to culture filtrates from each f necrophorum strain, and cell viability was determined, using the trypan blue dye exclusion test. two methods were used for production of the leukotoxin: (1) medium m-1 continuous dialysis sac cultures and (2) brain-heart infusion agar plate cultures. supernatant cultural fluids cont ...	1982	7103216
surgical management of multiple hepatic abscesses using ultrasonography for sequential evaluation.		1982	7123304
studies of fusobacterium necrophorum from bovine hepatic abscesses: biotypes, quantitation, virulence, and antibiotic susceptibility.	isolates of fusobacterium necrophorum were obtained from 124 bovine hepatic abscesses (in 119 cattle) and from the ruminal contents of 12 cattle. three biotypes (a, ab, and b) were found. type a isolates were most common in hepatic abscesses, and type b isolates were most common in ruminal contents. virulence studies in mice indicated that type a isolates were more pathogenic than types ab or b isolates. the difference in virulences between types a and b isolates was not related to the toxicity ...	1982	7149404
[fusobacterium necrophorum associated with actinomyces odontolyticus septicemia ].	the authors have observed a case of fusobacterium necrophorum associate with actinomyces odontolyticus septicemia, which appears to be the first case reported. in a 19 year old man, 15 blood cultures allowed to isolate both germs. clinical manifestations were: acute-like abdomen, encephalitis, myocarditis and pleural effusion. treatment with amoxicillin and metronidazole was successful.	1982	6750527
induction of immunologic memory by a lipopolysaccharide-protein complex isolated from fusobacterium necrophorum: humoral response.	the serum antibody response in balb/c mice to a lipopolysaccharide-protein (lps-p) complex was monitored by the enzyme-linked immunosorbent assay, total and 2-mercaptoethanol-resistant hemagglutination, and radial immunodiffusion. dose-response analyses demonstrated that suitable primary doses of lps-p injected iv or im induced substantial concentrautions of specific serum immunoglobulin (ig) m and igg. moreover, these values were greatly enhanced with small-dose booster injections. inoculation ...	1982	6807141
[septicemia due to fusobacterium necrophorum. a case report].	septicemia due to the anaerobic gram-negative bacillus fusobacterium necrophorum is exceptional. it may originate in tonsillitis or intestinal or gynecological infection. we report one case in a young man with head injury. fusobacterium necrophorum is frequently associated with aerobic pathogens such as streptococcus or staphylococcus (more than fifty per cent of the cases). metastatic localizations are numerous, often pleuro-pulmonary (infarction, abscess), hepatic (cytolysis) and meningeal (pu ...	1982	6302852
histopathology of mixed anaerobic intraabdominal infection in mice.	this study characterized acute peritonitis and chronic abscess formation resulting from experimental mixed anaerobic infection with bacteroides melaninogenicus and fusobacterium necrophorum. at intervals after infection liver and spleen samples were obtained, fixed, and processed for histological examination. an acute to chronic infection progressed in mice infected with this mixture of anaerobic bacteria, whereas, no infection resulted when either organism was injected alone. acute inflammatory ...	1982	6126612
host response to mixed anaerobic infection with bacteroides melaninogenicus and fusobacterium necrophorum.		1983	6132881
[determination of the enzymatic traits of anaerobic gram-negative nonsporulating bacteria].	the method requiring the use of a semi-liquid medium with the reduced content of protein hydrolysates and with bromo-thymol blue added as indicator and permitting the determination of sugar fermentation by bacteroids and fusobacteria is presented. the determination is made by a change in the color of the indicator and the intensity of microbial growth (opacity) after the incubation of the inoculated medium under free access of air. a study has been made for comparing the above method with the el ...	1983	6314710
the survival of anaerobic bacteria at 4 degrees c and 22 degrees c on swabs in three transport systems. statistical evaluation by application of a variance component model.	the survival of anaerobic bacteria on swabs in three transport systems at 4 degrees c and 22 degrees c was evaluated. the transport systems were a charcoal-impregnated cotton swab in modified stuart's transport medium (ms), a plain cotton swab in a dry aerobic tube (da) and a plain cotton swab in an aerobic agar tube (aa). the test strains were bacteroides fragilis, b. melaninogenicus ss. intermedius, fusobacterium necrophorum, peptostreptococcus anaerobius, eubacterium lentum and clostridium ra ...	1983	6346789
the recovery of anaerobic bacteria from swabs in three transport systems. statistical evaluation by application of a variance component model.	the recovery of six anaerobic species from swabs in three transport systems was quantitatively evaluated. the test strains were bacteroides fragilis, b. melaninogenicus ss. intermedius, fusobacterium necrophorum, peptostreptococcus anaerobius, eubacterium lentum, and clostridium ramosum. the transport systems were a charcoal-impregnated cotton swab in modified stuart's transport medium (ms), or a plain cotton swab in either a dry aerobic tube (da) or an aerobic agar tube (aa). swabs were charged ...	1983	6346790
[pathogenicity of fusobacterium. apropos of 2 cases].	two cases of severe septico-pyohaemia due to fusobacterium necrophorum are reported. clinical data from human cases and experimental results from infections of laboratory animal with fusobacterium necrophorum suggest: the important role of individual factors which enhance anaerobic growth (i.e. decrease of tissular redox potential); the involvement of thrombophlebitis with septic thrombi increasing the frequency of metastases; the early and long-lasting bacterial localisation in tissues, particu ...	1983	6348666
bovine rumenitis - liver abscess complex: a bacteriological review.	fusobacterium necrophorum is considered to be a member of the normal rumen flora and is the primary etiologic agent of bovine liver abscesses. of the three biotypes of f. necrophorum, a, b, and c, only biotypes a and b have been implicated in the disease. type b is the predominant biotype isolated from ruminal lesions and type a is the predominate biotype isolated from liver abscesses. type a is usually found in pure culture in the liver abscesses; whereas, type b is usually found in mixed cultu ...	1983	6349929
pathogenic synergism of fusobacterium necrophorum and other bacteria in formation of liver abscess in balb/c mice.		1983	6368925
fusobacterium necrophorum isolated from a hepatic abscess and from mastitic udder secretions in a heifer.	strains of fusobacterium necrophorum were isolated from secretions of an udder affected with mastitis (4 strains), an adjacent unaffected udder (3 strains), a superficial inguinal lymph node (2 strains) and a liver abscess (4 strains). these 13 strains were examined bacteriologically together with three known strains: f. necrophorum vpi-2891 and vpi-6161, and sphaerophorus necrophorus (f. necrophorum) n-167. all strains produced butyric acid from glucose and propionic acid from lactic acid, were ...	1983	6372575
cellular fatty acid and soluble protein profiles of oral fusobacteria.	we compared the cellular fatty acid and protein content of 43 strains of oral fusobacteria isolated from patients with chronic gingivitis, acute necrotizing ulcerative gingivitis, and juvenile and adult periodontitis, as well as from the stump-tailed macaque, to that of eight reference strains of oral and non-oral fusobacterium species. a gas-liquid chromatographic examination of trimethylsilyl derivatives of the fatty acid methyl esters revealed n14:0, 3-oh-14:0, n16:0, 16:1, 3-oh-16:0, n18:0, ...	1983	6581193
comparative biological features of a rat liver abscess model induced with three fusobacterium necrophorum strains.	several biological features were compared in a rat liver abscess model, using intraportal inoculations with 3 bovine strains of fusobacterium necrophorum which varied in virulence. serum alanine aminotransferase activities were increased significantly (p less than 0.05) in rats inoculated with f necrophorum 2101 by postinoculation hours 6, 12, and 24. thereafter, alanine aminotransferase values returned to base line for the remainder of the experiment. also, rats inoculated with f necrophorum 21 ...	1983	6625335
jaw disease in macropod marsupials: bacterial flora isolated from lesions and from the mouths of affected animals.	bacterial infections of the jaws are a common cause of death in macropods. lesions and oral cavities from 50 affected animals yielded wide ranges of aerobic and anaerobic organisms. the most frequent isolate from lesions (81%) was fusobacterium necrophorum, generally combined with other bacteria, but in 5 lesions, in pure culture. it was also isolated from 61% of mouths and this was the chief difference between the oral flora of affected and normal macropods. other groups of organisms isolated f ...	1983	6636509
[anaerobic septicemia following oropharyngeal infections (lemierre's postanginal septicemia): a forgotten syndrome].	two cases are reported of lemierre's post-anginal septicemia. one was fatal due to extensive septic pneumonia, while the other presented as acute osteomyelitis. both cases were preceded by oropharyngeal infections.	1983	6665544
cysteine conjugate beta-lyase in the gastrointestinal bacterium fusobacterium necrophorum.	a cysteine conjugate beta-lyase from the anaerobic gastrointestinal bacterium fusobacterium necrophorum was purified 51-fold by heat treatment, ammonium sulphate fractionation, gel-filtration chromatography, and anion-exchange chromatography. this enzyme catalyses the cleavage of the thioether linkage in cysteine conjugates of the following s-alkyl- or s-aryl-linked compounds: cysteine conjugate of propachlor (2-s-cysteinyl-n-isopropylacetanilide); 1,2-dihydro-1-hydroxy-2-s-cysteinylnaphthalene ...	1983	6673379
bacteria in enteric lesions of cattle.	thirty-nine species of bacteria were isolated from or demonstrated in the abomasal and small and large intestinal mucosa of 23 adult cattle and 41 calves and identified. the bacteria isolated were related to the gross and microscopical lesions. campylobacters, clostridium perfringens type a, c sordellii, actinobacillus lignieresii, fusobacterium necrophorum, mycobacterium paratuberculosis, aeromonas hydrophila and escherichia coli were all associated with specific lesions. the relationship of ot ...	1983	6829137
experimental hepatic necrobacillosis infection in cattle.	viable cultures of fusobacterium necrophorum were inoculated into the hepatic portal veins of 7 cattle. the experimentally produced hepatic necrobacillosis lesions were described from 30 minutes through 36 hours. the lesions were established by 2 different host-bacterial interactions. most frequent, microabscesses were initiated by diffusely distributed bacteria and were observed from 30 minutes through 2 hours. gross abscesses from 3 through 8 hours had centrally located abscess cores and were ...	1983	6839780
fusobacterium necrophorum septicemia.		1983	6854884
metabolism of mercapturic acid-pathway metabolites of 2-chloro-n-isopropylacetanilide (propachlor) by gastrointestinal bacteria.	1. mercapturic acid pathway metabolites of propachlor, labelled with 14c, were incubated with pig caecal contents, small and large intestinal contents, and pure cultures of gastrointestinal bacteria. 2. the glutathione, cysteine, n-acetylcysteine, and the s-oxide of the n-acetylcysteine conjugates of propachlor (2-chloro-n-isopropylacetanilide) were each metabolized by mixed pig caecal micro-organisms to 2-mercapto-n-isopropylacetanilide. 3. the extent of formation of 2-mercapto-n-isopropylaceta ...	1983	6880239
necrobacillosis in wildebeest calves.		1983	6887442
aetiological agents of necrobacillosis in captive wallabies.	in a series of 27 wallabies (macropus rufogriseus) with necrobacillosis, 14 animals were affected in the face, nine in the leg and six in the internal organs, two being affected in more than one site. fusobacterium necrophorum was the predominating organism, occurring in 69 per cent of lesions, usually in heavy and occasionally in pure culture. bacteroides species (six in all), often in considerable numbers, were found in 48 per cent of lesions, and f nucleatum in 14 per cent. aerobes or faculta ...	1984	6463385
hepatic abscess formation in cattle inoculated with fusobacterium necrophorum.		1984	6482128
aspects of bacteriology and endocrinology of cows with pyometra and retained fetal membranes.	in an effort to clarify the pathogenesis of pyometra, 20 cows with retained fetal membranes and 20 without, but with contemporary calving dates were studied. they were palpated and their uteri were subjected to sample collections for bacteriologic cultural examinations twice weekly for 4 weeks. blood samples were obtained each day and evaluated for serum progesterone concentration. three cows without and 3 with retained fetal membranes developed pyometra during the study, resulting in 3 groups d ...	1984	6524717
isolation of fusobacterium necrophorum from a case of bovine mastitis.		1984	6525120
biochemical and functional properties of a leucocidin produced by several strains of fusobacterium necrophorum.	a soluble exotoxin (a leucocidin) which was lethal to peripheral blood leucocytes from cattle, sheep, rabbits and man (in order of decreasing sensitivity) was elaborated by a variety of isolates of fusobacterium necrophorum when the majority of organisms were present as filaments in liquid culture. maximum production of the leucocidin was achieved by concentrations of bacteria equivalent to between 4 x 10(7) and 4 x 10(8) short cells per ml of culture above which no further increase in titre was ...	1984	6534355
necrotizing pneumonia after pharyngitis due to fusobacterium necrophorum.	a case of necrotizing pneumonia secondary to fusobacterium necrophorum is reported. this anaerobic infection commonly originates in the upper respiratory tract and is often accompanied by multiple system disease due to hematogenous seeding. when the lungs are involved, diffuse necrotizing pneumonia with pleural effusions and cavitation results. the course is prolonged, and the diagnosis is frequently delayed. with appropriate antibiotics, the prognosis is good.	1984	6694861
the pathogenic properties of fusobacterium and bacteroides species from wallabies and other sources.	intracerebral inoculation was more effective than intraperitoneal, intravenous or subcutaneous inoculation as a means of producing lethal infections with fusobacterium necrophorum in mice. strains varied in virulence but, of five examined, two had ld50 values as low as ca. 8000 and 14000 viable organisms. profuse bacterial multiplication in the brain was demonstrated. intravenous vaccination with a single large dose of heat-killed whole culture or washed bacterial cells failed to protect against ...	1984	6707469
pathogenicity of anaerobic gram-negative rods: possible mechanisms.	the literature dealing with the pathogenicity of anaerobic gram-negative rods in humans is reviewed. knowledge concerning definite pathogenic mechanisms is, at best, cursory. there is evidence that encapsulation plays a role in the pathogenicity of bacteroides fragilis and some of the black-pigmented bacteroides. a range of enzymes, among them collagenase and iga protease, are produced by several bacteroides species. supernatants of fusobacterium necrophorum cultures may be leukotoxic. synergism ...	1984	6729337
an experimental model for pyogenic liver abscess.	we have developed a reproducible small-animal model for pyogenic liver abscess, suitable for investigating diagnostic and therapeutic modalities. male new zealand white rabbits weighing 2-3 kg were anaesthetized and the liver exposed. gentle pressure was applied with forceps to the right hepatic lobe. a suspension of 10(5) colony forming units (cfu) escherichia coli plus fusobacterium necrophorum (10(6) cfu) plus bacteroides fragilis (10(6) cfu) was immediately injected into a mesenteric vein. t ...	1984	6373947
isolation of obligate anaerobic bacteria from bovine abscesses in sites other than the liver.	a survey in japan showed that of 2036 slaughtered cattle 58(3%) had abscesses in sites other than the liver. in 21 of the affected animals the lesions were pulmonary and in 32 abdominal (excluding hepatic); in five animals the lesions were found elsewhere (muscle 2, skin 2, bone 1). nineteen (33%) of the 58 cattle also had abscesses in the liver. obligate anaerobes alone were isolated from 17(29%) of the affected animals (fusobacterium necrophorum 14, bacteroides spp. 2, peptostreptococcus anaer ...	1984	6389873
necrobacillosis: a forgotten disease.	over four years five previously healthy young adults developed necrobacillosis , a severe septicaemic illness caused by fusobacterium necrophorum. the infections were characterised by sore throat followed by rigors and the formation of metastatic abscesses and all caused considerable diagnostic confusion.	1984	6426626
purification and partial characterization of fusobacterium necrophorum hemagglutinin.	hemagglutinin (hain) of fusobacterium necrophorum was separated from the bacterial cells by trypsinization-sonication, and purified by the gel filtration on sephadex g-100 column. the final product obtained from gel filtration gave one precipitin line in the immunodiffusion gel and produced a single band in polyacrylamide gel electrophoresis. the molecular weight of the hain was estimated to be about 19000 by sodium dodecyl sulfate polyacrylamide gel electrophoresis. it was heat labile and compa ...	1984	6442509
pleomorphism of fusobacteria isolated from the cockroach hindgut.	fusobacteria are commonly isolated from the hindgut of the cockroach eublaberus posticus . eleven strains isolated from e. posticus by us were keyed to four species, fusobacterium necrophorum, f. varium , f. gonidiaformans , and f. prausnitzii , using current taxonomic criteria. with the exception of f. gonidiaformis , all species showed rods with swollen centers and large bodies. the pleomorphism of f. varium was examined by phase microscopy and scanning and transmission electron microscopy. th ...	1984	6144663
efficacy of ethylenediamine dihydriodide as an agent to prevent experimentally induced bovine foot rot.	ethylenediamine dihydriodide (eddi) was administered by capsule and as a feed premix to cattle in 2 studies. in study i (32 steers), eddi was given at 0, 12.5, 50, and 200 mg/animal each day and in study ii (36 steers) at 0, 30, and 200 mg/animal each day. serum iodine levels were monitored during the studies. the cattle were inoculated intradermally in the interdigital space with a mixture of fusobacterium necrophorum and bacteroides melaninogenicus to induce acute foot rot at day 15 (study i) ...	1984	6146277
efficacy of ethylenediamine dihydriodide in the prevention of naturally occurring foot rot in cattle.	the efficacy of an ethylenediamine dihydriodide containing salt mixture was evaluated with regard to the prevention of naturally occurring foot rot in pastured cattle. ninety-six cattle were assigned to the treatment group and 96 were assigned to the control group. the groups were allowed consumption of salt-mineral mixtures, ad libitum, that were identical, except with respect to iodine concentration. the control group's mixture contained 0.0025% iodine and the treatment group's mixture contain ...	1984	6151816
duration of the microsomal enzyme (cytochrome b560ms) inducer action and imprinting potential of a steroid in tetrahymena.	tetrahymena subjected to a three-day exposure to the steroid triamcinolone exhibited a decreased microsomal enzyme activity, three days after treatment, followed by a slight and a considerable activity increase over the control at one and two weeks after treatment, respectively. reexposure to triamicinolone after return to plain medium for three days accounted for a marked increase in the inducer action which, however, failed to persist for an appreciable time.	1984	2129255
clinical models for anaerobic bacterial infections in dogs and their use in testing the efficacy of clindamycin and lincomycin.	two canine models of clinical anaerobic bacterial infections were developed for the study of the clinical parameters associated with these infections and for evaluation of antimicrobial agents that might be useful in therapy. in model i, a mixed culture of bacteroides fragilis, b melaninogenicus, and fusobacterium necrophorum was used as the inoculum. in model ii, a mixed culture of b fragilis and clostridium perfringens combined with an infection enhancer (sterile cinder dust) was used as the i ...	1984	24049887
correction on fluoride content.		1985	268368
successful transfer of embryos recovered from a cow with chronic cervicitis of mixed aerobic and anaerobic bacterial aetiology a case report.	an imported 13-year-old simmentaler cow was presented with severe purulent cervicitis and endometritis from which corynebacterium pyogenes , fusobacterium necrophorum , bacteroides melaninogenicus and an untyped clostridium perfringens were isolated. the endometritis responded to treatment but the cervix did not and remained fibrous, continuously patent and purulent. natural pregnancy was considered unlikely and the cow was prepared as an embryo transfer donor. eight embryos were recovered and s ...	1985	16726028
the role of fusobacterium necrophorum and bacteroides melaninogenicus in the aetiology of interdigital necrobacillosis in cattle.	when cultures of known pathogenic strains of fusobacterium necrophorum, isolated either from cattle or sheep were injected through the interdigital skin of cattle typical lesions of interdigital necrobacillosis were produced. the inclusion of bacteroides melaninogenicus in the inoculum did not appear to contribute to the development of lesions.	1985	2859848
infectious oral necrosis (cancrum oris) in nigerian children: a review.	the devastating orofacial gangrenous disease known as cancrum oris (noma) is still commonly seen in underprivileged nigerian children. these children are usually victims of such stressors as chronic malnutrition, numerous endemic communicable diseases and severe adverse physical conditions which may lead to depletion of their adaptive resources or produce physiological maladaptation to additional stressors. measles is the most common infection preceding the development of noma in nigerian childr ...	1985	2861938
"in vivo" and "in vitro" antagonism exerted by two anaerobic strains against strains of clostridium perfringens.		1985	2862639
peroxisomal oxidases and suggestions for the mechanism of action of insulin and other hormones.		1985	2863924
development of enzyme-linked immunosorbent assays for the detection of fusobacterium necrophorum antibody in animal sera.	enzyme-linked immunosorbent assays (elisa) for the detection of fusobacterium necrophorum antibody in the sera of rabbits, cattle, and sheep were developed, using a ribosome-rich extract (rre) from f necrophorum as the antigen. test character, including optimal antigen dilution and substrate incubation periods, was established, using rabbit, bovine, and ovine antisera produced against rre from isolates of f necrophorum. rabbit antisera produced against 7 other species of bacteria were used to te ...	1985	3970414
dissecting retropharyngeal abscess due to fusobacterium necrophorum in an adult.	i have described an adult patient who had dissecting retropharyngeal abscess complicated by pneumonia, mediastinitis, pericarditis, sepsis, and status epilepticus.	1985	3983669
satranidazole: experimental evaluation of activity against anaerobic bacteria in vitro and in animal models of anaerobic infection.	satranidazole, a 5-nitroimidazole derivative, was tested for its activity against reference strains and clinical isolates of anaerobic bacteria in vitro and in two murine models of anaerobic infection in comparison with metronidazole, tinidazole, ornidazole and clindamycin. the mic90 of satranidazole against 50 clinical isolates of anaerobes was 0.25 mg/l which was four-fold lower than the mic90 of metronidazole, tinidazole and ornidazole (mic90 = 1.0 mg/l). in a fatal murine infection with fuso ...	1985	4008378
plasmid in fusobacterium necrophorum.		1985	4010130
cyclopentenyl cytidine analogue. an inhibitor of cytidine triphosphate synthesis in human colon carcinoma cells.	the mechanism of action of the cyclopentenyl analogue of cytidine, ccyd, was investigated in human colon carcinoma cell line ht-29. upon exposure of cells to 10(-6)m ccyd, cell viability was reduced to 20% of control, whereas cytocidal activity was not present after 2 hr of drug exposure. cell lethality was partially reversible by urd, cyd or dcyd at 10(-6)m ccyd, and fully reversible by these nucleosides at 2.5 x 10(-7)m ccyd. the incorporation of [14c]dthd and [3h]urd into dna and rna was inhi ...	1985	4015694
fecal mutagenicity arising from ingestion of fried ground beef in the human.	fried ground beef has been shown to contain mutagens, and the major mutagenic component has been identified as 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (meiqx). mutagens in feces of 3 adult volunteers were fractionated by treatment of the feces with blue cotton followed by chromatography on a carboxymethyl cellulose column. the chromatographic fraction, corresponding to meiqx in terms of the position of elution, was examined for mutagenicity in s. typhimurium ta98 with metabolic activation. ...	1985	4022023
technique for percutaneous pulmonary arterial catheterization in conscious dogs.	a technique was developed to allow percutaneous placement and exchange of pulmonary arterial catheters in conscious dogs. seven dogs were catheterized weekly for 5 weeks, using a 10-gauge over-the-needle cannula. a no. 7 f flow-directed catheter was passed through the cannula to measure right heart and pulmonary arterial pressures and to calculate cardiac output. the flow-directed catheter was removed and replaced with an arteriographic catheter, and a pulmonary arteriogram was performed. placem ...	1985	4026036
aggregation of platelets by fusobacterium necrophorum.	broth cultures and washed cells of 13 of 24 bovine isolates of fusobacterium necrophorum aggregated human platelets in platelet-rich plasma. the cell-free culture fluid was inactive. bacteria stored at 4 degrees c in saline remained active for at least 3 months, but they did not release activity into the storage solution. aggregation typically began within 1 min after the addition of 10(3) bacteria to 10(3) platelets was complete within 5.5 min. assays for cytosolic lactic dehydrogenase revealed ...	1985	4031037
elevation in blood sialic acid and mucoprotein levels during hepatic abscess in cattle.		1985	4032925
isolation of a bacteriophage in fusobacterium necrophorum.		1985	4032936
antitumour activity of some platinum compounds.	a group of cis-ethylenediammine platinum (ii) complexes were synthesized and their activity against sarcoma-180 ascites tumour cells in mouse was tested. one of the compounds, pt(hoch2ch2nhch2ch2nh2)cl2, showed significant antitumour activity having little toxicity to the host. like the parent compound, cis-ddp, it binds to dna, but transcription is not the primary process inhibited by these compounds. the drug-dna complex, though less toxic, was not more effective than the free drug.	1985	4038640
congenital cataracts in a free-ranging rhesus monkey.	this report documents the occurrence of congenital cataracts in a visually-impaired yearling rhesus monkey from the same matriline on cayo santiago in which a congenitally blind infant was born 2 years previously.	1985	4046005
effects of the components of fusobacterium necrophorum in experimental liver abscess formation in mice.		1985	4046264