Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| hiv-1 and kaposi's sarcoma. | 1996 | 8972281 | |
| spindle cells isolated from kaposi's sarcoma-like lesions of bkv/tat-transgenic mice co-express markers of different cell types. | to characterize murine spindle cells isolated from kaposi's sarcoma-like skin lesions developed in bk virus (bkv)/tat-transgenic mice. | 1996 | 8883582 |
| kaposi's sarcoma: relationship to a novel herpesvirus and advances in therapy. | 1996 | 8883626 | |
| oral manifestations associated with human immunodeficiency virus infection in a spanish population. | a study was made of the oral manifestations in 396 patients with human immunodeficiency virus (hiv) infection. the following risk groups were established: intravenous drug users (79.5%), homosexuals (7.8%), homosexual intravenous drug users (3.3%), heterosexuals (8.1%) and hemophiliacs/transfusion patients (1.3%). the oral lesions, in decreasing order of frequency, were: periodontal disease (78.28%), candidiasis (65.65%), hairy leukoplakia (16.16%), herpes simplex virus lesions (5.30%). kaposi's ... | 1996 | 8986962 |
| [a new gamma-2 herpesvirus, defined as hhv8 or kaposi's sarcoma herpes virus (kshv), could be involved in the pathogenesis of kaposi's sarcoma]. | 1996 | 9206783 | |
| progressive loss of cd8+ t cell-mediated control of a gamma-herpesvirus in the absence of cd4+ t cells. | a unique experimental model has been developed for dissecting the integrity of cd8+ t cell-mediated immunity to a persistent gammaherpesvirus under conditions of cd4+ t cell deficiency. respiratory challenge of major histocompatibility complex class ii -/- and +/+ c57bl/6j mice with the murine gammaherpesvirus 68 (mhv-68) leads to productive infection of both lung and adrenal epithelial cells. virus titers peak within 5-10 d, and are no longer detected after day 15. persistent, latent infection ... | 1996 | 9064346 |
| absence of kaposi's sarcoma-associated herpesvirus-like dna sequences in malignant vascular tumors of the serous membranes. | reports connect kaposi's sarcoma-associated herpesvirus (kshv) with various types of kaposi's sarcoma (ks) and body-cavity-based lymphomas (primary effusion lymphomas). kshv dna sequences have also been detected in a few non-ks malignant vascular tumors. to determine whether kshv is associated with malignant vascular tumors involving the body cavities, 11 primary vascular tumors of the serous membranes (4 angiosarcomas, 7 hemangioendotheliomas) were tested for kshv sequences by polymerase chain ... | 1996 | 8972473 |
| multicentric castleman's disease in hiv infection: a clinical and pathological study of 20 patients. | to describe, in a retrospective study, the clinical and pathological spectrum of multicentric castleman's disease (mcd) in hiv infection. | 1996 | 8924253 |
| anal neoplasia in persons with hiv infection. | aside from the neoplasms that are clearly related to immunodeficiency, such as non-hodgkin's lymphoma and kaposi's sarcoma, numerous observations have also shown an association between hiv infection and the incidence of cervical and anal neoplasms. human papillomavirus (hpv) is the etiologic factor in anogenital neoplasms, although the mechanisms of the association are not clearly understood. it is believed that several hpv genes are critical in the malignant cell transformation process. an etio ... | 1996 | 11363714 |
| new approaches to hiv treatment: interview with robert gallo. m.d. interview by john s. james. | dr. robert c. gallo, director of the institute of human virology, discusses the institute's mission, funding, hiv treatment research investigations, and his own personal projects. dr. gallo explains the working mechanics of the macrophage-derived chemokine, a chemokine known to effectively block hiv; reasons why the national institute of health (nih) grants need to be hypothesis-driven; what has been learned about human chorionic gonadotropin's potential as a treatment for kaposi's sarcoma; and ... | 1997 | 11364917 |
| overview: kaposi's sarcoma, oral neoplasms. | since the last international workshop on the oral manifestations of hiv in 1993 there has been extremely rapid progress in our knowledge of the possible aetiology of kaposi's sarcoma (ks) and this is reflected in this section which concentrates mainly on the epidemiology and molecular aspects of ks. research continues in assessing potential links of oral neoplasms and especially in non-hodgkin's lymphomas in patients with hiv/aids. | 1997 | 9456672 |
| detection of human herpesvirus-8 dna in oral ulcer tissues of hiv-infected individuals. | to determine the frequency of detection of human herpesvirus-8 (hhv-8) in hiv-related oral ulcers. | 1997 | 9456675 |
| aetiology of kaposi's sarcoma: current understanding and implications for therapy. | kaposi's sarcoma is an angiogenic neoplasm composed of endothelial and spindle cells. the enormous increase in kaposi's sarcoma with hiv infection, and recent discovery that a new human herpesvirus (kaposi's sarcoma-associated herpesvirus, also called human herpesvirus 8) is present in this tumor, has activated intense interest in the aetiology, epidemiology and pathogenesis of this disease. today, kaposi's sarcoma is one of the most frequent neoplasms in men under 50 years old in the usa, and i ... | 1997 | 9430784 |
| kaposi's sarcoma-associated herpes virus--a new concern for human reproduction? | the detection of the recently discovered kaposi's sarcoma-associated herpes virus (kshv) in human immunodeficiency virus-uninfected donor semen and in blood from a normal blood donor has led us to review this new area of health concern, with emphasis on a number of studies conducted into the presence of the virus in semen and the possibility of transmission during assisted conception procedures. | 1997 | 9436709 |
| etiology and pathogenesis of posttransplant tumors: new insights into viral oncogenesis. | 1997 | 9869881 | |
| kaposi's sarcoma-associated herpesvirus (kshv)/human herpesvirus 8 (hhv8)--a new human tumour virus. | recently, a novel dna virus has been molecularly cloned from kaposi's sarcoma (ks) tissue, a tumour common in acquired immune deficiency syndrome (aids). analysis of the viral genome confirms that it is a relative of human herpesviruses and the virus has been designated hhv-8. epidemiological evidence suggests a strong aetiological link between the presence of hhv-8 dna and/or antibodies against the virus, and ks. additional sequence analysis suggests that the hhv-8 genome contains sequences whi ... | 1997 | 9349227 |
| ultrastructural characterization of human herpesvirus 8 (kaposi's sarcoma-associated herpesvirus) in kaposi's sarcoma lesions: electron microscopy permits distinction from cytomegalovirus (cmv). | kaposi's sarcoma (ks) has been shown by molecular techniques to be associated with infection with human herpesvirus 8 (hhv8/kshv), but specific ultrastructural characterization of the virus has been impaired by the frequent presence in these lesions of other herpesviruses, particularly cytomegalovirus (cmv). since the ultrastructural appearance of hhv8/kshv has been studied in the cell line ks-1 uninfected with other viruses including cmv, it was possible to undertake a comparative study of cmv ... | 1997 | 9349229 |
| human herpesvirus 8 dna sequences in angiosarcoma of the face. | 1997 | 9349352 | |
| follicular dendritic cell sarcoma complicated by hyaline-vascular type castleman's disease in a schizophrenic patient. | follicular dendritic cell (fdc) sarcoma is an exceedingly rare neoplasm of unknown pathogenesis. a case of fdc sarcoma complicated by the hyaline-vascular type castleman's disease occurring in a schizophrenic male is presented. swelling of the left cervical lymph node appeared in a 44-year-old male schizophrenic who had been medicated with major tranquilizers for 20 years. he had had a history of cervical lymphadenopathy 14 years before, for which a diagnosis of hyaline-vascular type castleman's ... | 1997 | 9361105 |
| herpes viral cyclin/cdk6 complexes evade inhibition by cdk inhibitor proteins. | the passage of mammalian cells through the restriction point into the s phase of the cell cycle is regulated by the activities of cdk4 and cdk6 complexed with the d-type cyclins and by cyclin e/cdk2. the activities of these holoenzymes are constrained by cdk inhibitory proteins. the importance of the restriction point is illustrated by its deregulation in many tumour cells and upon infection with dna tumour viruses. here we describe the properties of cyclins encoded by two herpesviruses, herpesv ... | 1997 | 9367157 |
| the kshv/hhv8-infected bcbl-1 lymphoma line causes tumors in scid mice but fails to transmit virus to a human peripheral blood mononuclear cell graft. | the body-cavity-based lymphoma cell line bcbl-1, which is infected with kaposi's sarcoma-associated herpesvirus/human herpesvirus 8, was injected alone or with human peripheral blood mononuclear cells into scid mice. immunoblastic lymphomas developed at or near the site of injection. the lymphomas appeared to derive exclusively from the injected bcbl-1 cells and not from the injected human pbmc. the tumors elicited a marked murine angiogenic response, but known angiogenic cytokines were not dete ... | 1997 | 9375005 |
| human herpesvirus 8 dna sequences in blistering skin from patients with pemphigus. | human herpesvirus 8 (hhv-8) has been detected in kaposi sarcoma (ks) and other lesions in patients both seropositive and seronegative for the human immunodeficiency virus (hiv). kaposi sarcoma has been reported to develop in a disproportionate number of patients with pemphigus. since hhv-8 is so strongly associated with ks, we wondered whether hhv-8 is present in pemphigus lesions from patients without ks or hiv infection. pemphigus lesions and skin from healthy individuals were coded in a blind ... | 1997 | 9382563 |
| establishment of hhv-8-positive and hhv-8-negative lymphoma cell lines from primary lymphomatous effusions. | primary lymphomatous effusions are represented by cases of non-hodgkin's lymphoma (nhl) which grow in liquid phase in the serous body cavities in the absence of solid tumour masses. based on morphologic, immunophenotypic, virologic and genotypic features, primary lymphomatous effusions are distinguished into body cavity-based lymphoma (bcbl), burkitt's lymphoma (bl) and immunoblastic large-cell lymphoma. the histogenesis and pathogenesis of primary lymphomatous effusions are virtually unclarifie ... | 1997 | 9389573 |
| absence of human herpesvirus 8 and epstein-barr virus genome sequences in cutaneous epithelial neoplasms arising in immunosuppressed organ-transplant patients. | recent studies have implicated herpesvirus 8 and epstein-barr virus in the development of cutaneous malignancies in immunosuppressed patients. in order to examine the strength of this association, we examined 37 malignant, pre-malignant and benign cutaneous epithelial neoplasms removed from immunosuppressed organ recipients for the presence of human herpesvirus 8 and epstein-barr viral genome sequences using polymerase chain reaction (pcr) and in situ hybridization. we examined 2 actinic keratos ... | 1997 | 9404853 |
| the liver in aids. | deficits in cell-mediated immunity in aids result in a wide variety of hepatic complications, including granulomas, cytomegalovirus hepatitis, multimicrobial aids cholangiopathy, kaposi's sarcoma, and lymphoma. kupffer cells are the major hepatic target cell population for human immunodeficiency virus-1 (hiv-1), and rhesus monkeys with simian immunodeficiency virus infection have served as a model for ultrastructural analysis of viral clearance by these cells. the majority of patients with estab ... | 1997 | 9408969 |
| kaposi's sarcoma-associated herpesvirus infection and multiple myeloma. | 1997 | 9417642 | |
| kaposi's sarcoma-associated herpesvirus infection and multiple myeloma. | 1997 | 9417645 | |
| kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. | the recent discovery of dna sequences of a new human herpesvirus in kaposi's sarcoma (ks) has fueled speculation that this virus might cause ks. the mere presence, however, of a virus in a complex multicellular tumor like ks could just as well be construed as evidence of a passenger agent. we sought stronger evidence linking the ks-associated herpesvirus (kshv) to tumor formation by using in situ hybridization to investigate the specificity, constancy, and timing of kshv gene expression in ks tu ... | 1997 | 8985403 |
| high incidence of kaposi's sarcoma-associated herpesvirus and epstein-barr virus in tumor lesions and peripheral blood mononuclear cells from patients with kaposi's sarcoma in uganda. | with the advent of aids, kaposi's sarcoma (ks) has become one of the leading malignancies in sub-saharan africa. recently, dna sequences from a new human herpesvirus called ks-associated herpesvirus (kshv) or human herpesvirus type 8 have been found in ks tumor lesions in high frequency. analyses of tumor lesions from 38 ugandan ks patients indicated a uniform presence of kshv in ks tumor lesions as revealed by polymerase chain reaction and southern hybridization. in contrast, only 31% (11/36) o ... | 1997 | 9086156 |
| [pulmonary kaposi's sarcoma in a patient with the acquired immunodeficiency syndrome]. | cutaneous kaposi's sarcoma (ks) is a well-known manifestation of the acquired immunodeficiency syndrome, but pulmonary ks is very rare in japan. we encountered a 27-year-old japanese, homosexual man who had extensive pulmonary ks. he came to our hospital because of a cough and dyspnea. on admission, there were some small nodules on the skin, and examination of a biopsy specimen led to the diagnosis of ks. the test for the human immunodeficiency virus antibody was positive and the cd4+ cell count ... | 1997 | 9103865 |
| high-dose interferon-alpha2a exerts potent activity against human immunodeficiency virus type 1 not associated with antitumor activity in subjects with kaposi's sarcoma. | anti-human immunodeficiency virus type 1 (hiv-1) activity was assessed in hiv-1-infected homosexual and bisexual men receiving 18-36 miu/day of recombinant interferon (ifn)-alpha2a for kaposi's sarcoma (ks). the median baseline hiv-1 rna level was 4.99 log10 copies/ml. seventeen subjects (68%) showed an rna decline > or = .5 log10/ml, with a maximum at week 4 (median decline = 1.91, range = 3.64-1.15; p = .0007), after which rna levels stabilized. eight subjects (32%) with lower median initial c ... | 1997 | 9291341 |
| prevalence of human herpesvirus-8 in skin lesions. | a putative new herpesvirus, designated kaposi's sarcoma-associated herpesvirus (kshv) or human herpesvirus-8 (hhv-8) was recently identified in aids-related kaposi's sarcoma. the dna sequence of the virus is homologous to the gamma-herpesviruses such as herpesvirus saimiri or epstein-barr virus, both of which are tumorigenic, suggesting that this new virus may also be oncogenic. thus, we determined whether the virus is present in other skin lesions. dna samples from 118 skin specimens were teste ... | 1997 | 9292063 |
| aids-related kaposi's sarcoma: prospective validation of the aids clinical trials group staging classification. aids clinical trials group oncology committee. | to prospectively validate the aids clinical trials group (actg) staging classification for aids-associated kaposi's sarcoma (ks). | 1997 | 9294471 |
| herpes virus (kshv) associated kaposi sarcoma in a 3-year-old child with non-hiv-induced immunodeficiency. | a 3-year-old boy of german descent suffered from two episodes of streptococcus pneumoniae meningitis within 2 months. one month previously, the first skin lesion of kaposi sarcoma (ks) had been observed behind his right ear. during the following 2 years ks disseminated not only mucocutaneously but also to visceral organs. immunological evaluation revealed severe lymphocytopenia with reduced helper/suppressor t-cell ratio and impaired humoral immune response to pneumococci. extensive laboratory t ... | 1997 | 9208237 |
| kaposi's sarcoma-associated herpesvirus/human herpesvirus-8: a new virus in human pathology. | the discovery of a new human herpesvirus in kaposi's sarcoma (ks) tissue of patients with aids has opened up new vistas in virology and oncology. this herpesvirus was first descriptively named ks-associated herpesvirus (kshv), but was recently renamed human herpesvirus 8 (hhv8). kshv/hhv8 dna has been found in all forms of ks, suggesting that it might be involved in the pathogenesis of ks. in addition, kshv/hhv8 can be detected in both malignant and benign lymphoproliferative disease. kshv/hhv8 ... | 1997 | 9216532 |
| antiviral drug susceptibility of human herpesvirus 8. | we studied the susceptibility of human herpesvirus 8 (hhv-8) to a number of antiherpesvirus agents. the acyclic nucleoside phosphonate (anp) analogs cidofovir and hpmpa [(s)-1-(3-hydroxy-2-phosphonylmethoxypropyl)adenine] effected potent inhibition of hhv-8 dna synthesis, with 50% effective concentrations (ec50) of 6.3 and 0.6 microm, respectively. adefovir, an anp with both antiretrovirus and antiherpesvirus activity, blocked hhv-8 dna replication at a fourfold-lower concentration than did fosc ... | 1997 | 9420052 |
| simultaneous onset of primary cutaneous b-cell lymphoma and human herpesvirus 8-associated kaposi's sarcoma. | we report the simultaneous occurrence of kaposi's sarcoma (ks) and primary cutaneous b-cell lymphoma (cbcl) of the leg in a 79-year-old woman, seronegative for hiv-1, htlv-1 and htlv-2. the cbcl underwent complete clinical remission after local radiotherapy, whilst the ks became disseminated within a year following diagnosis. however, 2 years after the diagnosis of ks, the patient died with neurological symptoms. these were presumed to be due to involvement of the central nervous system by lymph ... | 1997 | 9217827 |
| kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8 encephalitis in hiv-positive and -negative individuals. | kaposi's sarcoma-associated herpesvirus (kshv) human herpesvirus type 8 (hhv-8) has been associated with kaposi's sarcoma and a variety of benign lymphoid proliferations including angioimmunoblastic lymphadenitis with dysproteinemia and castleman's disease. kshv/hhv-8 has also been associated with inflammatory conditions including interstitial pneumonitis. although herpesviruses are commonly associated with encephalitis in immunosuppressed individuals, kshv/hhv-8 has not previously been associat ... | 1997 | 9233458 |
| a kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vil-6) activates signaling through the shared gp130 receptor subunit. | the present studies analyzed the biologic activity of a gene product (vil-6) encoded by the recently discovered kaposi's sarcoma-associated herpesvirus (kshv) bearing 24.8% amino acid identity with human interleukin-6 (huil-6). based on this similarity, we hypothesized that this viral homolog might trigger the jak/stat pathway, which typically is engaged by il-6 and other cytokines. activation of receptor-associated janus tyrosine kinases (jaks) results in the subsequent phosphorylation of signa ... | 1997 | 9235971 |
| epstein-barr virus latent gene expression in primary effusion lymphomas containing kaposi's sarcoma-associated herpesvirus/human herpesvirus-8. | primary effusion (body cavity-based) lymphoma (pel) is a recently recognized subtype of malignant lymphoma that exhibits distinctive clinical and biological features, most notably its usual infection with the kaposi's sarcoma-associated herpesvirus (kshv). the vast majority of cases also contain epstein-barr virus (ebv). this dual viral infection is the first example of a consistent dual herpesviral infection in a human neoplasm and provides a unique model to study viral interactions. we analyze ... | 1997 | 9242551 |
| kaposi's sarcoma-associated herpesvirus sequences in benign lymphoid proliferations not associated with human immunodeficiency virus. | kaposi's sarcoma-associated herpesvirus (kshv) dna sequences have been identified in approximately 95% of kaposi's sarcoma (ks) lesions and primary effusion lymphomas (pels), suggesting a pathogenetic role for this virus in these lesions. however, kshv has also been identified in a variety of specimens, including lymph nodes, peripheral blood b cells, semen, and prostate tissue, with varying frequencies. this suggests that kshv, like epstein-barr virus, may be ubiquitously distributed. to evalua ... | 1997 | 9264363 |
| kaposi's sarcoma as manifestation of immunosuppression in organ transplant recipients. | we report 2 patients, negative for human immunodeficiency virus (hiv) antibodies, who developed generalized kaposi's sarcoma (ks), one 5 months after renal transplantation while receiving cyclosporin a and prednisone, and the other 24 months after heart transplantation while receiving cyclosporin a, azathioprine and prednisone. reduction of the immunosuppressive therapy combined with chemotherapy and radiotherapy in both cases led to a remission of ks without development of transplant rejection. | 1997 | 9267755 |
| [human herpesvirus 8 (kaposi's sarcoma-associated herpesvirus]. | 1997 | 9290315 | |
| emerging pathogens: the hong kong experience. | 1997 | 9594216 | |
| corrected prevalence of kaposi's sarcoma (ks)-associated herpesvirus infection prior to onset of ks. | 1997 | 9110091 | |
| kaposi's sarcoma and its management in aids patients. recommendations from a scandinavian study group. | ks is the most frequent malignancy in homo/bisexual male aids patients, affecting more than 30% of these patients. ks may present itself as a few innocent cutaneous lesions or may show progression resulting in severe morbidity and mortality. approximately half of the patients may develop severe progressive disease. the prognosis of patients with progressive disease is poor, with a median survival of less than 6 months. there is no cure for aids-related ks, but several therapies are available for ... | 1997 | 9112290 |
| exacerbations of clinical symptoms in human immunodeficiency virus type 1-infected patients with multicentric castleman's disease are associated with a high increase in kaposi's sarcoma herpesvirus dna load in peripheral blood mononuclear cells. | the epidemiologic link between multicentric castleman's disease (mcd) and kaposi's sarcoma (ks) and the high frequency of ks herpesvirus (kshv) detection in both diseases raise the question of a role of this new virus in the pathogenesis of mcd. to explore this hypothesis, the kshv dna load was investigated in peripheral blood mononuclear cells of 3 human immunodeficiency virus (hiv)-infected patients with mcd at different points during the clinical course. clinical parameters, such as fever and ... | 1997 | 9129085 |
| herpesvirus-like dna sequences in kaposi's sarcoma lesions from two women with aids. | 1997 | 9314474 | |
| occurrence of human herpes virus 8 in kaposi's sarcoma and other tumours in south africa. | 1997 | 9323419 | |
| hhv-8 in pbmc and kaposi's sarcoma activity. | 1997 | 9334874 | |
| does hiv tat protein also regulate genes of other viruses present in hiv infection? | 1997 | 9149528 | |
| resolution of kaposi's sarcoma associated with undetectable level of human herpesvirus 8 dna in a patient with aids after protease inhibitor therapy. | 1997 | 9344209 | |
| primary plasmacytoma of lymph nodes. | primary plasmacytoma of the lymph nodes is very rare, and there are fewer than 20 reported cases. these cases appeared to have a better prognosis than other extramedullary plasmacytomas, with rare recurrence and no progression to myeloma after treatment. to better characterize the clinicopathological features and the pathogenesis of primary plasmacytoma of the lymph nodes, we reviewed our consultation files and retrieved seven such cases. the age of presentation ranged from 39 to 76 years (media ... | 1997 | 9308734 |
| malignant tumors and aids. | one in six patients with acquired immunodeficiency syndrome (aids) both in the usa and europe develop malignancies, in particular kaposi's sarcoma (ks) and non-hodgkin's lymphoma (nhl). after an initial rapid increase, the proportion of aids patients with ks steadily declined in the usa and in europe, while the proportion of aids-nhl has been stable during the last decade in the usa and europe. human immunodeficiency virus (hiv) infected patients are living longer due to advances in antiretrovir ... | 1997 | 9309244 |
| cell-homologous genes in the kaposi's sarcoma-associated rhadinovirus human herpesvirus 8: determinants of its pathogenicity? | 1997 | 9151804 | |
| absence of human herpesvirus 8 dna in benign and malignant endothelial lesions. | 1997 | 9350784 | |
| hiv-associated human herpesvirus 8-positive primary lymphomatous effusions: radiologic findings in six patients. | to define the imaging features of body cavity-based lymphoma (bcbl) related to the acquired immunodeficiency syndrome. this is a peculiar type of non-hodgkin lymphoma harboring infection by human herpesvirus 8 (hhv-8) and displaying a peculiar tropism for the serous body cavities. | 1997 | 9356629 |
| hhv-8 and aids-related cns lymphoma. | human herpesvirus 8 (hhv-8), the kaposi's sarcoma (ks)-associated herpesvirus, is closely related to the transforming epstein-barr virus (ebv) and may be detected in aids-related, ebv-containing, body-cavity-based lymphomas. accordingly, we analyzed 27 ebv-positive, aids-related cns lymphomas for hhv-8 sequences. only one tumor yielded hhv-8 sequences; this tumor arose in a patient with concomitant systemic lymphoma and a history of ks. we conclude that hhv-8 is unlikely to have a major role in ... | 1997 | 9153468 |
| complete remission of aids-related kaposi's sarcoma associated with undetectable human herpesvirus-8 sequences during anti-hiv protease therapy. | 1997 | 9365774 | |
| non-hodgkin lymphoma and kaposi sarcoma in an eyelid of a patient with acquired immunodeficiency syndrome. multiple viruses in pathogenesis. | a 36-year-old patient with acquired immunodeficiency syndrome sought care because of an upper eyelid lesion that dramatically increased in size. the histopathologic examination revealed a high-grade diffuse large cell non-hodgkin lymphoma in continuity with a kaposi sarcoma. in situ hybridization revealed epstein-barr virus in the large cell lymphoma and kaposi sarcoma-associated herpesvirus in the kaposi sarcoma lesion. this collision tumor is an unusual presentation of 2 malignant neoplasms in ... | 1997 | 9366682 |
| lack of serologic evidence for involvement of human herpesvirus 8 in autoimmune diseases. | 1997 | 9336431 | |
| human herpesvirus 8 in kaposi's sarcoma of an hiv-negative japanese woman with adult t-cell leukemia. | 1997 | 9163629 | |
| utility of fine needle aspiration in hiv-positive patients with corresponding cd4 counts. four years' experience in a large inner city hospital. | to assess the utility of fine needle aspiration (fna) in human immunodeficiency virus (hiv)-positive patients with corresponding cd4 count analysis. | 1997 | 9167706 |
| hiv-1 tat induces the expression of the interleukin-6 (il6) gene by binding to the il6 leader rna and by interacting with caat enhancer-binding protein beta (nf-il6) transcription factors. | human immunodeficiency virus type 1 (hiv-1) infection is associated with severe psoriasis, b cell lymphoma, and kaposi's sarcoma. a deregulated production of interleukin-6 (il6) has been implicated in the pathogenesis of these diseases. the molecular mechanisms underlying the abnormal il6 secretion of hiv-1-infected cells may include transactivation of the il6 gene by hiv-1. here we report the molecular mechanisms of tat activity on the expression of the il6 gene. by using 5' deletion mutants of ... | 1997 | 9169458 |
| detection of human herpes virus 8 dna and sequence polymorphism in classical, epidemic, and iatrogenic kaposi's sarcoma in south africa. | the aetiology and detection of human herpes virus type 8 (hhv-8) dna sequences in kaposi's sarcoma (ks) is a matter of intense investigation. we report on the detection of hhv-8 dna and sequence polymorphism in different clinicopathological subtypes of cutaneous ks samples from south africa. the diagnosis was confirmed by histological examination in all cases. six patients had classic ks (cks), 3 epidemic ks (eks), and 3 iatrogenic ks (iks). a nested polymerase chain reaction (pcr) assay was use ... | 1997 | 9179764 |
| interleukin-4 receptor expression on aids-associated kaposi's sarcoma cells and their targeting by a chimeric protein comprised of circularly permuted interleukin-4 and pseudomonas exotoxin. | aids-associated kaposi's sarcoma (aids-ks) represents one of the most common malignancies associated with human immunodeficiency virus infection. to target effective therapeutic agents to aids-ks, we have identified a new target in the form of interleukin-4 receptors (il-4r). | 1997 | 9205948 |
| no evidence of kshv/hhv-8 in mycosis fungoides or associated disorders. | the recently discovered human virus known as kaposi's sarcoma-associated herpesvirus (kshv) or human herpesvirus-8 (hhv-8) has been associated with body-cavity-based lymphomas in aids patients. it is most closely related to two other herpesviruses, the epstein-barr virus and herpesvirus saimiri, which are known to be associated with lymphomas in humans and nonhuman primates, respectively. to determine whether kshv/hhv-8 is involved in the pathogenesis of mycosis fungoides (mf) and related disord ... | 1997 | 9182822 |
| kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients. | kaposi's sarcoma-associated herpesvirus (kshv) was found in the bone marrow dendritic cells of multiple myeloma patients but not in malignant plasma cells or bone marrow dendritic cells from normal individuals or patients with other malignancies. in addition the virus was detected in the bone marrow dendritic cells from two out of eight patients with monoclonal gammopathy of undetermined significance (mgus), a precursor to myeloma. viral interleukin-6, the human homolog of which is a growth fact ... | 1997 | 9188529 |
| propagation of a human herpesvirus from aids-associated kaposi's sarcoma. | 1997 | 9190501 | |
| kaposi's sarcoma-associated herpesvirus encodes a functional cyclin. | kaposi's sarcoma-associated herpesvirus (kshv) (also called human herpesvirus 8) is consistently found in kaposi's sarcoma lesions and in body-cavity-based lymphomas. a 17-kb kshv lambda clone was obtained directly from a kaposi's sarcoma lesion. dna sequence analysis of this clone identified an open reading frame which has 32% amino acid identity and 53% similarity to the virus-encoded cyclin (v-cyclin) of herpesvirus saimiri (hvs) and 31% identity and 53% similarity to human cellular cyclin d2 ... | 1997 | 9032330 |
| kaposi's sarcoma-associated herpesvirus: a lymphotropic human herpesvirus associated with kaposi's sarcoma, primary effusion lymphoma, and multicentric castleman's disease. | despite extensive epidemiological evidence suggesting that kaposi's sarcoma (ks) has an infectious origin, a specific viral association with ks had not been documented until recently, when two novel dna fragments were identified in ks lesional tissue from a patient with the acquired immunodeficiency syndrome (aids). these fragments belong to a previously unidentified human herpesvirus, called ks-associated herpesvirus (kshv), or human herpesvirus 8. although this virus is generally absent from n ... | 1997 | 9044510 |
| sequences of human herpesvirus 8 are not detected in various non-kaposi sarcoma vascular lesions. | 1997 | 9236539 | |
| a bcl-2 homolog encoded by kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with bax or bak. | the bcl-2 protein family is characterized by the ability to modulate cell death, and members of this family share two highly conserved domains called bcl-2 homology 1 (bh1) and 2 (bh2) which have been shown to be critical for the death-repressor activity of bcl-2 and bcl-xl. through sequence analysis we identified a novel viral bcl-2 homolog, designated ksbcl-2, from human herpesvirus 8 (hhv8) or kaposi sarcoma-associated herpesvirus. the overall amino acid sequence identity between ksbcl-2 and ... | 1997 | 9012846 |
| selective switch between latency and lytic replication of kaposi's sarcoma herpesvirus and epstein-barr virus in dually infected body cavity lymphoma cells. | the bc-1 cell line, derived from a body cavity-based, b-cell lymphoma, is dually infected with epstein-barr virus (ebv) and kaposi's sarcoma-associated herpesvirus (kshv). in these studies, the relationships between these two gammaherpesviruses and bc-1 cells were characterized and compared. single-cell cloning experiments suggested that all bc-1 cells contain both genomes. in more than 98% of cells, both viruses were latent. the two viruses could be differentially induced into their lytic cycle ... | 1997 | 8985352 |
| detection of serum antibodies to a kaposi's sarcoma-associated herpesvirus-specific peptide. | kaposi's sarcoma (ks)-associated herpesvirus/human herpesvirus type 8 (kshv/hhv-8) may play an etiologic role in the pathogenesis of ks. in an attempt to assess kshv/hhv-8 infection, an elisa was developed using an 18-amino acid peptide from a putative minor capsid protein of kshv/hhv-8 conjugated to bovine serum albumin. overall, sera from human immunodeficiency virus type 1 (hiv-1)-positive patients with ks had a higher reactivity in the assay than did sera from hiv-1-positive patients without ... | 1997 | 9129068 |
| kaposi's sarcoma and sex hormones. | 1997 | 9108954 | |
| characterization of ribonucleoprotein complexes containing an abundant polyadenylated nuclear rna encoded by kaposi's sarcoma-associated herpesvirus (human herpesvirus 8). | infection with kaposi's sarcoma-associated herpesvirus (kshv) (also called human herpesvirus 8) is strongly linked to all forms of kaposi's sarcoma. we have previously identified two polyadenylated kshv transcripts that are actively transcribed in kaposi's sarcoma (ks) tumors and in kshv-infected b-lymphoma cells. one of these rnas (termed t1.1 or nut-1 rna) is a 1.1-kb transcript present in a subpopulation of ks tumor cells. this rna is localized to the nucleus of infected cells and has no open ... | 1997 | 8995643 |
| pirated genes in kaposi's sarcoma. | 1997 | 9002510 | |
| detection of the herpesvirus-like dna sequences in matched specimens of semen and blood from patients with aids-related kaposi's sarcoma by polymerase chain reaction in situ hybridization. | the dna sequences of a novel human gamma-herpesvirus type 8 (hhv-8) have recently been detected in kaposi's sarcoma (ks) lesions obtained from different populations in whom this neoplasm occurs, suggesting that this virus may be implicated in the etiology and/or pathogenesis of ks. to study the distribution and possible means of transmission of the putative viral agent, specimens of ks skin lesions, matched uninvolved skin, peripheral blood mononuclear cells (pb-mcs), and semen were collected fr ... | 1997 | 9006331 |
| kaposi sarcoma, kaposi sarcoma-associated herpesvirus, and human t-cell lymphotropic virus type 1. what is the current evidence for causality? | 1997 | 9006376 | |
| kaposi sarcoma-associated herpesvirus/human herpesvirus type 8 and epstein-barr virus in iatrogenic kaposi sarcoma. | 1997 | 9006388 | |
| circulating spindle cells: correlation with human herpesvirus-8 (hhv-8) infection and kaposi's sarcoma. | 1997 | 9014921 | |
| a single 13-kilobase divergent locus in the kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genome contains nine open reading frames that are homologous to or related to cellular proteins. | two small fragments of a novel human gammaherpesvirus genome known as kaposi's sarcoma (ks)-associated herpesvirus or human herpesvirus 8 (hhv-8) have been shown to be present in virtually all aids and non-aids ks lesions, as well as in body cavity-based lymphomas (bcbl) and in multicentric castleman's disease. we have extended those studies by identifying and sequencing a third fragment of hhv-8 dna encoding a viral thymidylate synthetase (ts) gene. use of this viral ts fragment as a probe led ... | 1997 | 9032328 |
| antiviral activity of tumor-suppressor pathways: clues from molecular piracy by kshv. | a common feature of many tumor viruses is that they possess genes that produce specific proteins to inhibit major cellular tumor-suppressor pathways. despite intensive studies, the reasons why these diverse and unrelated viruses have independently evolved oncogenes remains obscure. kaposi-sarcoma-associated herpesvirus (kshv or hhv8) has pirated a number of recognizable cellular genes that are key to cell survival and proliferation. in this review, we provide an overview of the known activities ... | 1998 | 9594662 |
| high prevalence of antibodies to human herpesvirus 8 in relatives of patients with classic kaposi's sarcoma from sardinia. | a survey for antibodies to a recombinant small viral capsid antigen (svca) of human herpesvirus type 8 (hhv-8) was conducted in sardinia, one of the world's highest incidence areas for classic kaposi's sarcoma (ks). prevalence of antibodies to hhv-8 svca was greatest in patients with ks (95%), followed by family members (39%) and a sardinian control population age- and sex-matched to the relatives (11%). within families, prevalence of antibodies was about equal among spouses, children, and sibli ... | 1998 | 9607855 |
| overview of the epidemiology of immunodeficiency-associated cancers. | immunodeficiency, be it congenital, therapeutic, or infectious in origin, increases the risk of certain, but not all, types of cancer. a common feature of these cancers is that specific infectious agents appear to be important in their etiology, not only in immunodeficient subjects but also in the general population. people with acquired immunodeficiency syndrome (aids) are at an increased risk of kaposi's sarcoma, non-hodgkin's lymphoma, hodgkin's disease, squamous cell carcinoma of the conjunc ... | 1998 | 9709294 |
| cancers in human immunodeficiency virus-infected children. | although the exact incidence of cancers in human immunodeficiency virus (hiv)-infected children is not clear, an excess of non-hodgkin's lymphomas and soft tissue tumors as well as a multitude of otherwise rare tumors in childhood, such as cervical, thyroid, or pulmonary carcinoma, has been reported. in contrast to the findings in hiv-infected adults, kaposi's sarcoma is rare in children in industrialized countries but not in children living in the sub-saharan area. treatment of the neoplastic d ... | 1998 | 9709300 |
| squamous cell carcinomas after allogeneic bone marrow transplantation for aplastic anemia: further evidence of a multistep process. | secondary solid tumors are rare events occurring in patients who underwent allogeneic marrow transplantation for aplastic anemia and fanconi's anemia. human herpes virus 8 (hhv8), epstein-barr virus (ebv), and human papillomaviruses (hpv) sequences have been found in squamous cell carcinoma (scc) occurring in organ transplant recipients. the tumor suppressor gene p53 has been strongly linked to the occurrence of scc in the nonimmunocompromised population. | 1998 | 9753353 |
| kaposi's sarcoma-associated herpesvirus-encoded oncogenes and oncogenesis. | molecular biologic studies of kaposi's sarcoma-associated herpesvirus (kshv) have identified a number of potential viral oncogenes that may contribute to kshv-related neoplasia including a d-type cyclin, an il-6-like cytokine, and a novel member of the interferon regulatory factor family. kshv is functionally related to other dna tumor viruses by encoding specific proteins to inhibit prb, pro-apoptotic, and interferon-signaling tumor suppressor pathways. the virus appears to employ molecular pir ... | 1998 | 9709306 |
| kaposi's sarcoma-associated herpesvirus. | kaposi's sarcoma (ks) is a vascular tumor predominantly found in the immunosuppressed. epidemiologic studies suggest that an infective agent is the etiologic culprit. kaposi's sarcoma-associated herpesvirus (kshv), or human herpesvirus-8 (hhv-8), is a gamma human herpesvirus present in all epidemiologic forms of ks and also in a rare type of a b cell lymphoma, primary effusion lymphoma (pel). in addition, this virus is present in most biopsies from human immunodeficiency virus (hiv)-associated m ... | 1998 | 9709807 |
| antibodies to kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in patients with multiple myeloma. | kaposi's sarcoma-associated herpesvirus (kshv) serologic assays were used to detect specific antibodies to kshv lytic and latent antigens in 27 patients with multiple myeloma, 27 control patients with other cancers, and 50 random blood donors. antibodies to kshv recombinant minor capsid antigen orf65 were found in 81% of patients with multiple myeloma, 22% of control patients with other cancers, and 6% of the blood donors. antibodies to kshv latent nuclear antigens were found in 52% of patients ... | 1998 | 9728556 |
| human herpesvirus-8 orf k8.1 gene encodes immunogenic glycoproteins generated by spliced transcripts. | a cdna library from phorbol ester-induced human herpesvirus-8 (hhv-8) carrying bcbl-1 cells was screened with an hiv+ks+ serum, and several cdna clones encoding hhv-8 proteins were identified. sequence analysis of two full-length cdna clones show open reading frames (orfs) encoded by spliced messages originating from the hhv-8 k8.1 gene. one cdna encodes an orf of 228 amino acids, designated k8. 1.a, with a cleavable signal sequence, a transmembrane domain, and four n-glycosylation sites. the sp ... | 1998 | 9740785 |
| spectrum of aids-associated malignant disorders. | 1998 | 9743013 | |
| transfusion virology: progress and challenges. | discoveries of new human viruses and new technologies for their detection have made, and will continue to make, major contributions to the safety of blood transfusion. this article discusses the practical issues involved in the implementation of additional serological screening tests for viruses such as human t-lymphotropic virus, and reviews current information on the prevalence and pathogenicity of more recently discovered viruses, such as hepatitis g virus (hgv) or gb virus-c (gbv-c) and huma ... | 1998 | 9745887 |
| treatment of classical kaposi's sarcoma with intralesional injections of cidofovir: report of a case. | the effect of intralesional injections of cidofovir, a nucleotide analog with potent in vitro activity against human herpesvirus 8 (hhv-8), was studied in vivo in an hiv-negative patient with classical kaposi's sarcoma (ks). after five weekly injections of the drug, no clinical, histological, immunohistological, or virological changes could be detected in comparison with saline-injected lesions. these findings suggest that, once the ks tumor has developed, active viral replication is no longer i ... | 1998 | 9624609 |
| trauma-induced kaposi's sarcoma of the hallux. an unusual case. | kaposi's sarcoma is the most common malignant lesion in patients who test seropositive for the human immunodeficiency virus. although many cases of this tumor have been described in the literature, only a few cases have been related to koebner's phenomenon following trauma. biopsy of lesions remains the standard method of diagnosis, but the numerous treatment options available today require treatment to be determined on a case-by-case basis. the authors present an unusual case of trauma-induced, ... | 1998 | 9791955 |
| mapping and serodiagnostic application of a dominant epitope within the human herpesvirus 8 orf 65-encoded protein. | a dominant epitope within the human herpesvirus 8 (hhv8) orf 65-encoded protein was mapped to an 8-amino-acid (aa) sequence (rkppsgkk [aa 162 to 169]) by an amino acid replacement method. using a 14-aa peptide (p4) encompassing this epitope as the antigen, we developed an enzyme immunoassay for hhv8 antibodies. the presence of p4 antibodies in a panel of 61 human serum specimens was highly correlated with biopsy-confirmed kaposi's sarcoma. the homologous epstein-barr virus peptide derived from b ... | 1998 | 9620379 |
| human immunodeficiency virus tat modulates the flk-1/kdr receptor, mitogen-activated protein kinases, and components of focal adhesion in kaposi's sarcoma cells. | kaposi's sarcoma (ks) spindle cell growth and spread have been reported to be modulated by various cytokines as well as the human immunodeficiency virus (hiv) gene product tat. recently, hiv-1 tat has been shown to act like a cytokine and bind to the flk-1/kdr receptor for the vascular endothelial growth factor a (vegf-a), which is expressed by ks cells. we have characterized signal transduction pathways stimulated by hiv-1 tat upon its binding to surface receptors on ks cells. we observed that ... | 1998 | 9621077 |
| the immunogenic glycoprotein gp35-37 of human herpesvirus 8 is encoded by open reading frame k8.1. | human herpesvirus 8 (hhv-8) is likely to be involved in the pathogenesis of kaposi's sarcoma (ks) and body cavity-based lymphomas (bcbls). the hhv-8 genome is primarily in a latent state in bcbl-derived cell lines like bcbl-1, but lytic replication can be induced by phorbol esters (r. renne, w. zhang, b. herndier, m. mcgrath, n. abbey, d. kedes, and d. e. ganem, nat. med. 2:342-346, 1996). a 35- to 37-kda glycoprotein (gp35-37) is the polypeptide most frequently and intensively recognized by ks ... | 1998 | 9658120 |
| no association between human herpesvirus type 8 infection and multiple myeloma. | 1998 | 9665152 |