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factors correlated with peritoneal carcinomatosis and survival in patients with gastric cancer treated at a single institution in brazil.gastric cancer is the second leading cause of death due to cancer worldwide and is particularly prevalent in brazil. promising new therapeutic agents have already shown activity in some gastrointestinal malignancies and their role in gastric cancer will need to be evaluated. determining the prognostic factors of survival for patients with gastric cancer can help in identifying patients with a worse prognosis after treatment with the current chemotherapeutic regimens.200919705243
effects of chronic estradiol treatment on the thyroid gland structure and function of ovariectomized rats.estrogen therapy is widely used nowadays in women to treat many postmenopausal symptoms but it may have some undesirable effects due to multiple organs affection. so, the aim of this study was to determine the effects of chronic estradiol treatment on the structure and function of the thyroid gland in ovarictomized rats as a model simulating menopause.200919715616
staging and survival for sinus cancer in the pediatric population.to determine histology, staging, and survival for pediatric sinus cancer.200919720405
presence of intratumoral neutrophils is an independent prognostic factor in localized renal cell carcinoma.we have previously demonstrated a significant negative impact of intratumoral neutrophils in metastatic renal cell carcinoma. this study assessed intratumoral neutrophils in localized clear cell renal cell carcinoma (rcc).200919720929
tumor proteomic profiling predicts the susceptibility of breast cancer to chemotherapy.chemotherapy is often used for breast cancer treatment, but individual outcome varies widely. we hypothesized that tumor proteomic profiles obtained prior to chemotherapy may predict the individual tumor response to treatment. the goal of our study was to explore feasibility of using proteomic profiling to preselect patients for an effective chemotherapeutic regimen. tumors from 52 patients with t2-t4 breast cancer were prospectively collected before neoadjuvant chemotherapy, and were analyzed u ...200919724903
[efficacy of sugammadex in the reversal of neuromuscular blockade induced by rocuronium in long-duration surgery: under inhaled vs. intravenous anesthesia].sugammadex reverses neuromuscular blockade induced by aminosteroid agents by encapsulating these agents. the objective of this study was to compare the efficacy and safety of sugammadex to reverse a rocuronium-induced neuromuscular blockade in long-duration surgery in association with inhaled or intravenous anesthesia.200919725342
protease supplementation improves muscle function after eccentric exercise.protease supplementation has been purported to reduce the damaging effects of eccentric exercise and accelerate recovery of muscle function, possibly by regulating inflammation.200919727022
far field potentials from brain stem after transcutaneous vagus nerve stimulation: optimization of stimulation and recording parameters.the method of vagus somatosensory evoked potentials (vsep) was introduced to easily measure the activity of vagus brain stem nuclei. in alzheimer's disease, this measure was characterized by longer latencies as compared to controls while amplitudes did not show statistical significant differences at frontal and central recording sites. therefore, the influence of stimulation and recording parameters on amplitudes of vsep were systematically examined. in 20 healthy participants, vsep measurement ...200919728032
abnormal responses to trh in children born small for gestational age that failed to catch up.fifteen percent of small for gestational age (sga) children remain short and undergo thyroid axis evaluations.200919729948
pilot test of the salt mass casualty triage system.no existing mass casualty triage system has been scientifically scrutinized or validated. a recent work group sponsored by the centers for disease control and prevention, using a combination of expert opinion and the extremely limited research data available, created the salt (sort-assess-lifesaving interventions-treat/transport) triage system to serve as a national model. an airport crash drill was used to pilot test the salt system.200919731169
deconjugation of thyroxine glucuronide by the rat kidney.rapid deconjugation of administered thyroxine glucuronide (t4g) to thyroxine (t4) has been observed in human subjects. the goal of this study was to characterize, in the rat, the location and kinetics of this deconjugation process and to identify whether early conjugation of t4 to t4g occurs in the liver.200919731980
[magnetic resonance imaging in the preoperative staging of rectum cancer].the treatment of rectum cancer depends on the tumour stage, and until 2005 treatment included preoperative radiation therapy for the t3 and t4 cancer stages. an exact preoperative assessment of the cancer stage is therefore essential. in denmark rectal magnetic resonance imaging (mri) is used as a standard procedure in preoperative evaluation, sometimes supplemented by transrectal ultrasound (trus). the purpose of this study was to determine the accuracy of preoperative mri in tumour stage evalu ...200919732535
interstitial brachytherapy as boost for locally advanced t4 head and neck cancer.locally advanced squamous cell cancers of the head and neck (scchn) with bone and cartilage invasion (bci) or those with soft-tissue invasion (sti) have been treated with resection followedup with chemoradiotherapy (crt) or definitive crt. however, locoregional recurrence remained a large component of treatment failure. high-dose-rate interstitial brachytherapy (bt) has been used for dose escalation to further prevent local relapse. this is a review of our experience.200919733128
inhibitory effect of aluminium on calcium absorption in small intestine of rats with different thyroid hormone status.to analyse the influence of thyroid status on the effect of aluminium (al) upon intestinal calcium (ca) absorption, adult male wistar rats with experimentally altered thyroid hormones circulating levels, were orally treated (o.g.) with 0 (control), or 50 mg elemental al (as chloride)/kg body weight (b.w.) per day, for a 14 d period. hyper- and hypo-thyroid conditions were respectively achieved by means of administration of either sodium levothyroxine (50 microg/kg b.w. per day, o.g.) or methimaz ...200919733399
effect of a seashell protein haishengsu on the immunological function of mice with ehrlich ascites tumor.this study was designed to investigate the effect of a seashell protein haishengsu (hss) on the immuno logical function in mice with ehrlich ascites tumor. ehrlich ascites tumor-bearing mice were divided into three hss groups (25, 50 and 100 mg/kg, i.v., respectively), cyclophosphamide (10 mg i.p.) and control group. the immunological function was assessed by measuring the phagocytizing capacity of the peritoneal macrophages and neutrophils, as well as the number of spleen hemolytic plaque-formi ...200919874239
interactions of thyroid hormones; insulin-like growth factor-1 (igf-1), igf binding proteins, and nutritional anthropometric parameters in school children with goiter detected by palpation.in the present study we evaluated anthropometric indices, serum thyroid hormones, insulin-like growth factor-1 (igf-1) and igf- binding proteins (igfbps) levels, in children who has palpable goiter at endemic population. we aimed to 1) compare children with palpable goiter with healthy peers, 2) detect interaction of anthropometric indices, serum thyroid hormones, igf-1 and igfbps parameters in both groups 3) evaluate the effects of their nutritional status to these parameters.200919876794
cation localization and movement within dna thrombin binding aptamer in solution.the thrombin binding aptamer, 15-mer oligonucleotide d[g(2)t(2)g(2)tgtg(2)t(2)g(2)], was folded into the well known antiparallel unimolecular g-quadruplex in the presence of (15)nh(4)(+) ions. although the formed g-quadruplex is thermodynamically less stable than in the presence of k(+) ions, the loop conformations and folding topology are the same. on the other hand, titration of na(+) ions into an aqueous solution of tba resulted in the formation of one major and several minor species of g-qua ...200919865704
development of a clinical workflow tool to enhance the detection of vertebral fractures: accuracy and precision evaluation.image analysis model development.200919829258
high-frequency 30-mhz sonography in preoperative assessment of tumor thickness of primary melanoma: usefulness in determination of surgical margin and indication for sentinel lymph node biopsy.high-frequency sonographic imaging has been used for the preoperative evaluation of primary malignant melanoma. in the present study, to identify the usefulness of 30-mhz sonography for determination of the surgical margin and indication for sentinel lymph node biopsy, the correlation between sonometric and histometric tumor thickness was investigated.200919856051
classification of myoviridae bacteriophages using protein sequence similarity.we advocate unifying classical and genomic classification of bacteriophages by integration of proteomic data and physicochemical parameters. our previous application of this approach to the entirely sequenced members of the podoviridae fully supported the current phage classification of the international committee on taxonomy of viruses (ictv). it appears that horizontal gene transfer generally does not totally obliterate evolutionary relationships between phages.200919857251
ectopic synaptic ribbons in dendrites of mouse retinal on- and off-bipolar cells.the ectopic distribution of synaptic ribbons in dendrites of mouse retinal bipolar cells was examined by using genetic ablation of metabotropic glutamate receptor subtype 6 (mglur6), electron microscopy, and immunocytochemistry. ectopic ribbons were observed in dendrites of rod and on-cone bipolar cells in the mglur6-deficient mouse but not in those of wild-type mice. the number of rod spherules facing the ectopic ribbons in mglur6-deficient rod bipolar dendrites increased gradually during early ...200919859741
[combined spinal-epidural anesthesia for abdominal surgery in a patient with chronic obstructive pulmonary disease].a 69-year-old man (150 cm, 57 kg)who had been diagnosed as having copd, was admitted to our hospital because of abdominal pain and drowsiness. he was diagnosed as co2 narcosis and perforation of appendix. when he recovered from co2 narcosis, he was scheduled for elective ilectomy. because his pulmonary function was impaired, combined spinal and epidural anesthesia was selected. with the patient in the right lateral position, an epidural catheter was inserted at t12-l1 interspace, and spinal anes ...200919860242
restoration of pulmonary compliance after laparoscopic surgery using a simple alveolar recruitment maneuver.to test the hypothesis that a pulmonary maneuver designed to recruit additional alveoli (thereby decreasing atelectasis) applied before extubation can restore pulmonary compliance to baseline values.200919833275
coupling dna unwinding activity with primer synthesis in the bacteriophage t4 primosome.the unwinding and priming activities of the bacteriophage t4 primosome, which consists of a hexameric helicase (gp41) translocating 5' to 3' and an oligomeric primase (gp61) synthesizing primers 5' to 3', have been investigated on dna hairpins manipulated by a magnetic trap. we find that the t4 primosome continuously unwinds the dna duplex while allowing for primer synthesis through a primosome disassembly mechanism or a new dna looping mechanism. a fused gp61-gp41 primosome unwinds and primes d ...200919838204
thyroid tissue analysis through raman spectroscopy.the diagnosis of thyroid pathologies is usually made by cytologic analysis of the fine needle aspiration (fna) material. however, this procedure has a low sensitivity at times, presenting a variation of 2-37%. the application of optical spectroscopy in the characterization of alterations could result in the development of a minimally invasive and non-destructive method for the diagnosis of thyroid diseases. thus, the objective of this work was to study the biochemical alterations of tissues and ...200919838427
the genome and structural proteome of an ocean siphovirus: a new window into the cyanobacterial 'mobilome'.prochlorococcus, an abundant phototroph in the oceans, are infected by members of three families of viruses: myo-, podo- and siphoviruses. genomes of myo- and podoviruses isolated on prochlorococcus contain dna replication machinery and virion structural genes homologous to those from coliphages t4 and t7 respectively. they also contain a suite of genes of cyanobacterial origin, most notably photosynthesis genes, which are expressed during infection and appear integral to the evolutionary trajec ...200919840100
direct activator/co-activator interaction is essential for bacteriophage t4 middle gene expression.the bacteriophage t4 asia protein is a bifunctional regulator that inhibits transcription from the major class of bacterial promoters and also serves as an essential co-activator of transcription from t4 middle promoters. asia binds the primary s factor in escherichia coli, sigma(70), and modifies the promoter recognition properties of the sigma(70)-containing rna polymerase(rnap) holoenzyme. in its role as co-activator, asia directs rnap to t4 middle promoters in the presence of the t4-encoded ...200919843221
sheddase activity of tumor necrosis factor-alpha converting enzyme is increased and prognostically valuable in head and neck cancer.tumor necrosis factor alpha converting enzyme (tace) is a sheddase overexpressed in cancers that generates cancer cell growth and survival factors, and is implicated in carcinogenesis and tumor growth. this indicates that tace could be a potentially important cancer biomarker. unexpectedly, tace expression in cancer tissues does not correlate with cancer stage or invasiveness. although tace sheddase activity is a more direct and potentially better indicator of tace biology and might be a better ...200919843672
a randomized comparison of low doses of hyperbaric bupivacaine in combined spinal-epidural anesthesia for cesarean delivery.the aim of our study was to investigate the block characteristics of intrathecal hyperbaric bupivacaine 7, 8, or 9 mg administered during combined spinal-epidural anesthesia for cesarean delivery and to elucidate the dose that produces adequate sensory blockade for surgery while minimizing the incidence of hypotension, high neuroblockade, and the need for intraoperative epidural supplementation.200919843797
the classification and identification of human somatic and parasympathetic nerve fibres including urinary bladder afferents and efferents is preserved following spinal cord injury.single-fibre extracellular action potentials were recorded with 2 pairs of wire electrodes from lower human sacral nerve roots during surgery. the roots from which was recorded from were used for morphometry. nerve fibre groups were identified by conduction velocity distribution histograms of single afferent and efferent fibres and partly by nerve fibre diameter distribution histograms. the values of group conduction velocity and group nerve fibre diameter measured in the paraplegics were very s ...200919845099
left inferior quadrant oblique incision: a new access for hand-assisted device during laparoscopic low anterior resection of rectal cancer.although long-term results are not clear, laparoscopic resection of rectal cancer may be feasible, and the use of hand-assisted technique may ease the procedure. this article aims to describe the details of left inferior quadrant oblique incision (liqoi) and to discuss the results of patients who underwent laparoscopic hand-assisted low anterior resection using liqoi.200919845455
follow-up of low-risk differentiated thyroid cancer patients who underwent radioiodine ablation of postsurgical thyroid remnants after either recombinant human thyrotropin or thyroid hormone withdrawal.we previously demonstrated comparable thyroid remnant ablation rates in postoperative low-risk thyroid cancer patients prepared for administration of 3.7gbq (131)i (100 mci) after recombinant human (rh) tsh during t(4) (l-t4) therapy vs. withholding l-t4 (euthyroid vs. hypothyroid groups). we now compared the outcomes of these patients 3.7 yr later.200919850694
prognostic value of thymidine phosphorylase expression for pancreatic cancer.thymidine phosphorylase (tp) has an angiogenic activity, but the prognostic value of tp has not been fully validated for pancreatic cancer. the aim of this study was to evaluate tp expression according to clinicopathological parameters to define its prognostic value for pancreatic cancer.200919760965
ts-1 from first principles.first principles studies on periodic ts-1 models at ti content corresponding to 1.35% and 2.7% in weight of tio(2) are presented. the problem of ti preferential siting is addressed by using realistic models corresponding to the ts-1 unit cell [tisi(95)o(192)] and adopting for the first time a periodic dft approach, thus providing an energy scale for ti in the different crystallographic sites in nondefective ts-1. the structure with ti in site t3 is the most stable, followed by t4 (+0.3 kcal/mol) ...200919785451
thyroid hormone replacement after thyroid lobectomy.the purpose of this study was to determine the incidence of and identify risk factors for postoperative hypothyroidism in patients undergoing thyroid lobectomy.200919789012
lymph node evaluation is associated with improved survival after surgery for early stage gallbladder cancer.guidelines for the current national comprehensive cancer network recommend radical cholecystectomy, including hepatic resection and portal lymph node (ln) dissection, for patients with early stage gallbladder (gb) cancer. we sought to determine the survival benefit conferred by adequate ln evaluation.200919789030
severe food restriction induces myocardial dysfunction related to serca2 activity.previous studies have shown that food restriction promotes myocardial dysfunction in rats. however, the molecular mechanisms that are responsible are unclear. we investigated the role of sarcoplasmic reticulum ca2+-atpase (serca2) on myocardial performance in food-restricted rats. male wistar-kyoto rats, 60 days old, were fed a control or restricted diet (daily energy intake reduced to 50% of the control) for 90 days. expression of serca2a, phospholamban (plb), na+/ca2+ exchanger (ncx), and thyr ...200919794517
hepatocellular integrity during sevoflurane anesthesia with induced hypotension.the effect of sevoflurane anesthesia with or without induced hypotension on hepatocellular integrity was studied. forty adult consented patients scheduled for various urological procedures were allocated randomly to either ntg group (nitroglycerin-induced hypotension) or a control group of twenty patients each. anesthesia was induced and maintained by fentanyl, sevoflurane & vecuronium in both groups. in ntg group, nitro-glycerin infusion was adjusted to maintain mean arterial pressure (map) of ...200919795771
the free vascularized flap and the pectoralis major pedicled flap options: comparative results of reconstruction of the tongue.reconstruction after extensive resection of the tongue remains a surgical challenge. free soft-tissue transfer is now favored for head and neck reconstruction following cancer resection. however, the choice of either free tissue transfer (ftt) or of the pedicled pectoralis major musculocutaneous flap (pmmf), the workhorse in head and neck reconstruction, remains controversial. the purpose of this study is to assess the post-operative outcomes after radical ablative surgery and reconstruction for ...200919796982
behavior predictors of language development over 2 years in children with autism spectrum disorders.this exploratory study examined predictive relationships between 5 types of behaviors and the trajectories of vocabulary and language development in young children with autism over 2 years.200919797136
[a clinical verification of the chinese 2008 staging system for nasopharyngeal carcinoma].the chinese 2008 staging system for nasopharyngeal carcinoma (npc) was a common set of recommendations by initial revision of the previous'92 staging system. this study was to verify the chinese 2008 staging system and to provide evidence for its further revision.200919799808
abdomino-perineal resection for anal cancer: impact of a vertical rectus abdominis myocutaneus flap on survival, recurrence, morbidity, and wound healing.to evaluate the results of a vertical rectus abdominis myocutaneus (vram) flap after abdomino-perineal resection (apr) for anal cancer (ac).200919801930
control of skin colour and polyphenol oxidase activity in santol fruit by dipping in organic acid solution.this laboratory experiment was carried out at the department of agricultural technology, mahasarakham university, northeast thailand during july and august 2008. the experiment aimed to determine an effective natural organic acid that would delay the unattractive skin browning of santol fruit, while at the same time not damaging the quality of the fruit. the experiment included a study of the fruit's polyphenol oxidase (ppo) activity, phenolic content and quinone content, as they relate to colou ...200919803119
resection via median sternotomy in patients with lung cancer invading the main pulmonary artery.conventional pneumonectomy via posterolateral thoracotomy is not always possible in cases with t4 tumour with widespread pulmonary artery invasion. our objective is to present our surgical experiments in cases with a hilar mass who were thought to have pulmonary artery invasion, in whom we performed intrapericardial pneumonectomy through median sternotomy.200919803260
is umbilical cord blood total thyroxin measurement effective in newborn screening for hypothyroidism?to assess the performance of the use of umbilical cord blood for screening of primary congenital hypothyroidism in the saudi aramco medical services organization newborn thyroid screening programme.200919805752
breast carcinoma grading, estimation of tumor size, axillary lymph node status, staging, and nottingham prognostic index scoring on mastectomy specimens.breast carcinoma is the most common malignant tumor and the leading cause of cancer death in women. in western countries, a sharp increase in the detection of breast carcinoma, largely due to widespread use of mammography, has recently led to a fall in breast cancer mortality. this, however, is not true for less developed countries, in which mortality continues to rise.200919805950
clinical efficacy of two-phase leukocyte filtration in high-risk patients undergoing coronary revascularization with cardiopulmonary bypass.the purpose of this study was to investigate the clinical outcome, inflammatory response and myocardial function in high-risk patients undergoing three different leukocyte depletion strategies. over a four-month period, forty patients (euroscore 6+) undergoing coronary revascularization were prospectively randomized to one of the four perfusion protocols: group 1 (n=10): conventional circuits (ecc) + two leukocyte filters (lg6b, pall, usa) with the method of two-phase (continuous + strategic) le ...200919806797
comparison of bed planting-furrow irrigation with conventional planting-flood irrigation in durum wheat (t. durum desf) in southeastern turkey.there is no clear consensus regarding the advantages of bed planting with furrow irrigation over conventionally irrigated cropping. this 3-year study from southeastern turkey aimed to assess the limits to some input savings in bed planting-furrow irrigation in terms of yields and profitability of durum wheat. field trials were carried out using a randomized complete block design with six treatments and tree replications: t1: conventional planting-flood irrigation (cp-fi) with recommended practic ...200919806807
feeding value and in vitro digestibility of date-palm leaves supplemented with different supplementary energy.the aim of this study was to evaluate the feeding value and also the effect of different supplementary energy on increasing in vitro dm digestibility of date-palms leaves obtained in pruning. a randomized complete design with different energy supplementary with 3 replicates was conducted. harvested date-palm leaves were air-dried, ground through a 5 mm screen, then palm leaves (l) ensiled with different levels of urea (u) and other supplementary energy. combination, mixture was packed tightly in ...200919806815
results of trimodality therapy in patients with stage iiia (n2-bulky) and stage iiib non-small-cell lung cancer.the survival rates for stage iiia and stage iiib non-small-cell lung cancer (nsclc) are extremely poor with single-treatment modalities such as radiation therapy or surgery. the purpose of this study is to assess tolerability, response, surgical resectability, and survival of chemotherapy followed by chemoradiation therapy, and then followed by surgery in patients with stage iiia (n2-bulky) or stage iiib nsclc.200919808194
fungal exposure endocrinopathy in sinusitis with growth hormone deficiency: dennis-robertson syndrome.a retrospective study was carried out on 79 patients with a history of mold exposure, fatigue, and chronic rhinosinusitis (crs) to determine whether there is a causal relationship between fungal exposure and chronic sinusitis, fatigue, and anterior hypopituitarism, especially growth hormone deficiency (ghd). of the patients, 94% had a history of crs, endoscopically and/or computed tomography (ct) confirmed; 100% had chronic fatigue and 100% had either significant history of indoor mold exposure ...200919808744
do we need still more trials on t4 and t3 combination therapy in hypothyroidism?approximately 10% of hypothyroid patients are dissatisfied with the outcome of levothyroxine replacement. it is unlikely that slight over- or under-treatment with thyroxine (t(4)) explains remaining complaints. meta-analysis of randomized clinical trials shows no advantage of t(4)/tri-iodothyronine (t(3)) combination therapy over t(4) monotherapy. however, each of these trials can be criticized, and none is perfect: most of them failed to mimic the physiological ratio of serum free t(4) (ft(4)) ...200919808902
evaluation of the blood stabilizers transfix and cyto-chex bct for low-cost cd4 t-cell methodologies.transfix(tm) and cyto-chex((r)) bct (blood collection tube) reagents have been shown to maintain whole blood integrity for delayed immunophenotyping by flow cytometry. we evaluated the ability of these blood-stabilizing reagents to preserve hiv-seropositive blood for delayed cd4(+) t-cell quantification utilizing the dynal((r)) biotech t4 quant kit. transfix was added to edta-anticoagulated whole blood and tested at a 1:10 dilution over 7 d using the dynal (n = 21) manual method. compared to bas ...200919811090
effect of trimerization motifs on quaternary structure, antigenicity, and immunogenicity of a noncleavable hiv-1 gp140 envelope glycoprotein.the external domains of the hiv-1 envelope glycoprotein (gp120 and the gp41 ectodomain, collectively known as gp140) contain all known viral neutralization epitopes. various strategies have been used to create soluble trimers of the envelope to mimic the structure of the native viral protein, including mutation of the gp120-gp41 cleavage site, introduction of disulfide bonds, and fusion to heterologous trimerization motifs. we compared the effects on quaternary structure, antigenicity, and immun ...200919815247
[ct imaging study of anterior approaches to the upper thoracic spine].there are small smount of literatures on the study of the anterior surgical approaches to the upper thoracic spine (uts). moreover, there are many differences among the results of these studies. this study is to investigate the exposure ranges of different anterior surgical approaches to the uts for making the preoperative plan by means of ct images analysis.200919817203
characterization of tail sheath protein of giant bacteriophage phikz pseudomonas aeruginosa.the tail sheath protein of giant bacteriophage phikz pseudomonas aeruginosa encoded by gene 29 was identified and its expression system was developed. localization of the protein on the virion was confirmed by immunoelectron microscopy. properties of gene product (gp) 29 were studied by electron microscopy, immunoblotting and limited trypsinolysis. recombinant gp29 assembles into the regular tubular structures (polysheaths) of variable length. trypsin digestion of gp29 within polysheaths or exte ...200919822340
can quetiapine-induced hypothyroidism be reversible without quetiapine discontinuation?recent clinical trials and case reports have recorded dose-related thyroid function test abnormalities during quetiapine treatment usually requiring drug discontinuation or initiation of thyroid replacement therapy. the authors highlight the potential reversibility of quetiapine-induced hypothyroidism without quetiapine discontinuation in 2 in-patients (a 51-year-old schizophrenic woman and a 46-year-old bipolar man) to which quetiapine (300 and 350 mg/d, respectively) was administered. both pat ...200919820433
is there a benefit to sentinel lymph node biopsy in patients with t4 melanoma?controversy exists as to whether patients with thick (breslow depth>4 mm), clinically lymph node-negative melanoma require sentinel lymph node (sln) biopsy. the authors examined the impact of sln biopsy on prognosis and outcome in this patient population.200919827151
who is at risk for ongoing dizziness and psychological strain after a vestibular disorder?patients with vestibular vertigo syndromes often suffer from anxiety and depression, whereas patients with psychiatric disorders often experience subjective unsteadiness, dizziness, or vertigo. thus, it has been hypothesized that the vestibular system may be interlinked with the emotion processing systems. the aim of the current study was to evaluate this hypothesis by correlating vestibular and psychiatric symptoms with the course of the disease over 1 year. this interdisciplinary, prospective, ...200919828125
the clinical significance of fat clearance lymph node harvest for invasive rectal adenocarcinoma following neoadjuvant therapy.this study aimed to investigate the application of fat clearance in cases of rectal cancer after neoadjuvant chemoradiation.200919966611
regional anaesthesia for caesarean section: a choice of three techniques.over the last 20 years, there has been a large increase in the proportion of caesarean sections (brown and russell, 1995) which are performed under regional rather than general anaesthesia. a bilateral sensory block from the t4 dermatome (nipple level) to the sacral nerve roots (perineum) is necessary.200919966715
[endoscopic surgery using the low-temperature plasma radiofrequency for nasal inverted papilloma].to evaluate the effect of endoscopic surgery using the low-temperature plasma radiofrequency for nasal inverted papilloma. methods in a retrospective study, clinical data of 8 patients underwent endoscopic surgery were analyzed since july 2008. tumor stage according to krouse was t1:1, t2:6, t3:1, t4:0, respectively. t1 and t2 lesions were completed excised using the low-temperature plasma radiofrequency, t3 lesions were excised using microdebrider combined with plasma radiofrequency.200919957649
[combination of trans-anal intersphincteric resection and trans-abdominal total mesorectal excision for anus-retained ultra-low rectal tumors].to study the combination of trans-anal intersphincteric resection and transabdominal total mesorectal excision for anus-retained ultra-low rectal tumors.200919957808
[diagnostic significance and management principles of colorectal intraepithelial neoplasia].to discuss the significance of pathological diagnosis of colorectal intraepithelial neoplasia and its treatment principles.200919957809
cryoablation of stellate ganglia and atrial arrhythmia in ambulatory dogs with pacing-induced heart failure.there is an association between autonomic nerve discharges and atrial arrhythmias (including bradycardia and tachycardia) in ambulatory dogs with pacing-induced heart failure (hf).200919959128
[new tnm classification of malignant lung tumors 2009 from a pathology perspective].based on the iaslc multicenter data collected worldwide on 81495 patients diagnosed or registered with lung cancer between 1990 and 2000, the t, n, and m descriptors were analyzed and recommendations for changes in the seventh edition of the tnm classification were proposed on the basis of differences in survival. this new tnm classification replaces the old uicc classification and the staging system according to c. mountain 1997. the changes principally affect the t and m classifications. for t ...200919960300
intraluminal versus infiltrating gallbladder carcinoma: clinical presentation, ultrasound and computed tomography.to compare clinical presentation and ultrasound (us) and computed tomography (ct) sensitivity between intraluminal and infiltrating gallbladder carcinoma (gbca).200919960562
thyroid function tests: a review.in this paper, we review the tests that are executed to aid the diagnosis of thyroid dysfunction. thyroid function tests provide information at physiological, pathological and anatomical levels. along with history and physical examination they owe to many specific findings that are associated with thyroid functioning. so an attempt has been made to put forward a gist of thyroid function tests. serum tests of thyroid function are serum total thyroxine (t4), serum total triiodothyronin (t3), free ...200919961039
[construction of recombinant adenovirus vector containing rat insulin-like growth factor 1 gene and its expression in islet beta-cells].this study was aimed to construct the recombinant adenovirus containing rat insulin-like growth factor 1(rigf-1), and then to investigate its expression in islet beta-cells. rna was extracted using trizol from rat livers. rigf-1 cdna was obtained using rt-pcr. the purified rt-pcr products and padtrack-cmv were digested using bg1 ii and ecor v and religated by t4 dna ligase, then transformed into electro-competent jm109 bacteria and selected on kanamycin lb plates. this plasmid pad-cmv-rigf-1 was ...200919947492
the first appearance of sympathetic ganglia in human embryos at stage 13.the primordia of the sympathetic trunk ganglia were traced on serial sections of 10 embryos at stage 13 (32 postovulatory days). it was found that in all embryos, these primordia were present in the thoracic level t4 to t9 and they appeared as scattered aggregates of cells lying dorsally and laterally to the dorsal aortae.200919950069
[impact of tnm staging and treatment mode on the prognosis of non-small cell lung cancer].to study the impact of tnm staging and combined treatment mode on the survival of non-small cell lung cancer (nsclc) patients.200919950561
[cloning and prokaryotic expression of bifidobacterium infantis-mediated skdr and its effect on proliferation of vascular endothelial cells].to construct bifidobacterium infantis-mediated skdr gene transferring system and to investigate its effect on the proliferation of vascular endothelial cells.200919950583
[clinical analysis of adenoid cystic carcinoma of external auditory canal].to explore methods of treatment for adenoid cystic carcinoma of external auditory canal, and discuss the correlating factors that effect prognosis.200919954012
[laryngeal function preserving surgery in hypopharyngeal carcinoma].to evaluate the preservation of laryngeal function hypopharyngeal cancer surgery clinical effectiveness and impact of prognostic factors.200919954017
optimal lymph node dissection for t3-t4 lower rectal cancer, the so-called "high risk" group: the japanese experience. 200919954577
rare case of primary spinal ependymomatosis occurring in a 26-year-old man: a case report.the authors report a rare case of primary spinal ependymomatosis in a young adult man. multiple primary ependymomatous lesions were seen on magnetic resonance imaging and no anaplasia was identified on the surgical-pathological analysis. the aetio-pathological mechanism and surgical significance of this rare occurrence is discussed.200919946548
kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis.thyroid dysfunction is a global health concern, causing defects including neurodevelopmental disorders, dwarfism and cardiac arrhythmia. here, we show that the potassium channel subunits kcnq1 and kcne2 form a thyroid-stimulating hormone-stimulated, constitutively active, thyrocyte k+ channel required for normal thyroid hormone biosynthesis. targeted disruption of kcne2 in mice impaired thyroid iodide accumulation up to eightfold, impaired maternal milk ejection, halved milk tetraiodothyronine ( ...200919767733
train of four responses in paretic limbs.quadriplegic patients pose difficulty for neuromuscular monitoring owing to nonavailability of accessible normal muscle. it is known that train of four responses (t4/t1 ratio) was exaggerated in paretic limbs. however, no studies have quantified the exaggeration at different degrees of block. this study was undertaken to quantify the exaggeration of train of four responses in paretic limbs with increasing levels of block after the administration of neuromuscular blocking drugs. nine patients wit ...200919955896
perioperative monitoring of thromboelastograph on hemostasis and therapy for cyanotic infants undergoing complex cardiac surgery.this study investigated features and treatments of perioperative coagulopathies in cyanotic infants with complex congenital heart disease (cchd). thirty-six infants with cyanotic cchd were involved and divided into two groups: in group h (n = 20), hematocrit (hct) > 54%, and in group l (n = 16), hct < 54%. blood was sampled at anesthesia induction (t1), rewarming to 36 degrees c (t2), after heparin neutralization (t3), and 4 h after operation (t4). the hemostatic changes were evaluated by thromb ...200920021469
[diagnostic value of double contrast-enhanced ultrasonography in preoperative staging of gastric cancer].to evaluate the clinical value of double contrast-enhanced ultrasonography using oral and intravenous contrast agents in preoperative staging of gastric cancer.200920021869
[surgical treatment for bronchioloalveolar carcinoma with ipsilateral intrapulmonary metastatic nodules].the staging and treatment of bronchioloalveolar carcinoma (bac) with pulmonary metastasis are still controversial. this study aimed at evaluating the current staging of bac with ipsilateral intrapulmonary metastatic nodules and the therapeutic effectiveness of surgical resection.200920021955
biomechanical characteristics of different regions of the human spine: an in vitro study on multilevel spinal segments.study design.: an in vitro study on human multilevel spinal segments. objective.: to determine the differences in biomechanical characteristics between 4 separate regions of the human spine and to provide quantitative information is derived on the range of motion (rom), neutral zone (nz), neutral zone stiffness (nzstiff), and flexibility (flex). summary of background data.: limited literature is available about the biomechanical behavior of different regions of the human spine, in particular wit ...200920010393
thoracic pedicle subtraction osteotomy for fixed sagittal spinal deformity.study design.: a retrospective clinical study. objective.: to find the corrective capacity of a thoracic pedicle subtraction osteotomy (pso), determine if segmental correction is dependent on level, and to compute the impact of thoracic pso on regional and global spinal balance. summary of background data.: pso is a technique popularized in the lumbar spine primarily for the correction of fixed sagittal imbalance. despite several studies describing the clinical and radiographic outcome of lumbar ...200920010396
thoracic myelopathy secondary to intradural extramedullary bronchogenic cyst.to report a case of thoracic myelopathy secondary to intradural extramedullary bronchogenic cyst.200920025159
comparison of equipotent doses of ropivacaine-fentanyl and bupivacaine-fentanyl in spinal anaesthesia for lower abdominal surgery.the aim of this randomised, double-blind study was to compare equipotent doses of plain ropivacaine and bupivacaine (19.5 mg and 13 mg respectively), both with fentanyl 20 microg, for spinal anaesthesia in lower abdominal surgery. after written informed consent had been obtained, 52 asa i to ii male patients scheduled for lower abdominal surgery were randomly assigned to receive intrathecal plain ropivacaine 19.5 mg with fentanyl 20 microg (group r, n =26) or plain bupivacaine 13 mg with fentany ...200920014598
dominant mycobacterium tuberculosis lineages in elderly patients born in norway.during the previous century norway had a high incidence of tuberculosis, but no molecular epidemiological studies could be performed and these previously epidemic strains have been disappearing during the last decades. currently, tuberculosis among native norwegians is in the elimination phase, and it is still not known what type of m. tuberculosis was so efficiently controlled during the second half of the 20th century. however, many elderly norwegian-born people still develop tb that cannot be ...200920020043
clinical and biomaterial evaluation of a new condensed dual-function extracorporeal circuit in reoperation for coronary artery bypass surgery.this prospective, randomized study compared the clinical performance of three types of circuits: a newly introduced, fully-coated, interchangeable open-closed circuit with a dual configuration (hard shell with a bypass shunt), reduced length, and reduced prime of less than 800 cc (condecc); a completely coated circuit (ecc); and a similar uncoated, open circuit with standard length and prime (cont).200920020412
9 years follow-up of a patient with pituitary form of resistance to thyroid hormones (prth): comparison of two treatment periods of d-thyroxine and triiodothyroacetic acid (triac).patients with pituitary resistance to thyroid hormones (prth) exhibit features of hyperthyroidism due to normal sensitivity to thyroid hormones in some of the peripheral tissues. there is a lack of information in the literature on the long-term follow-up and treatment of patients with prth. here, we present long-term (9 years) clinical and biochemical follow-up of a patient with prth under the treatment of d-t4 initially (for 1.5 years) followed by triac for 5.5 years. an 11.5 year-old girl was ...200920020587
[combined surgical interventions for advanced thyroid carcinoma].an analysis of specificities of 141 combined operations for advanced (t4) papillary, follicular and medullary thyroid carcinoma has shown that such operations proved to be necessary in 5.4% out of 2606 patients operated for carcinoma of the thyroid gland (ctg). in most cases these operations were of organ-sparing character. in 10.5% of the patients circular resections of organs of the respiratory and digestive systems were fulfilled on the neck and head. complete removal of the tumor was obtaine ...200920020626
[indication for bone scans in early breast cancer staging].evaluate the indication for bone scanning during staging of early breast cancer in the light of scientific evidence to assess the need to modify practices with scant effectiveness.200919995533
serum cathepsin k and cystatin c concentration in patients with advanced non-small-cell lung cancer during chemotherapy.a pathogenic implication of cathepsin k (cath k) and its inhibitor - cystatin c (cyst c) occur to be of growing importance in the mechanisms of tumor invasiveness in lung cancer. this study was conducted to investigate the prognostic role and the effects of chemotherapy on serum cath k and cyst c (elisa) in patients with advanced stage non-small cell lung cancer (nsclc). the study entered 40 patients (32 men) and 15 healthy volunteers (control group). peripheral blood samples were taken before a ...200919995705
site-directed spin labeling of a genetically encoded unnatural amino acid.the traditional site-directed spin labeling (sdsl) method, which utilizes cysteine residues and sulfhydryl-reactive nitroxide reagents, can be challenging for proteins that contain functionally important native cysteine residues or disulfide bonds. to make sdsl amenable to any protein, we introduce an orthogonal labeling strategy, i.e., one that does not rely on any of the functional groups found in the common 20 amino acids. in this method, the genetically encoded unnatural amino acid p-acetyl- ...200919995976
spinal epidural hematoma following epidural catheter removal in a paraplegic patient.spinal epidural hematoma is a rare and devastating complication of epidural catheter removal in an anticoagulated patient. the diagnosis could be quite challenging, especially in patients with preexisting neurological deficits. a 35-year-old patient with remote spinal cord injury and t4 level paraplegia developed a spinal epidural hematoma on the 7th postoperative day. the hematoma developed after epidural catheter removal with concurrent administration of unfractionated heparin.200920006262
sensibility following innervated free tram flap for breast reconstruction: part ii. innervation improves patient-rated quality of life.restoring sensory innervation may be a useful adjunct in free flap head and neck reconstruction but, as yet, has not been shown to improve outcomes of breast reconstruction. the authors' previous study demonstrated objectively improved sensation in a group of innervated transverse rectus abdominis musculocutaneous (tram) flap breast reconstruction patients relative to noninnervated flaps. this study compared patient-rated outcomes of free tram breast reconstruction in innervated versus noninnerv ...200920009826
diabetic ketoacidosis, thyroiditis and alopecia areata in a child with down syndrome.a 10-year-old girl with down syndrome and alopecia areata was admitted with severe ketoacidosis. she had high blood glucose level: 615 mg/dl and her hbalc level was 13.3 %. after the control of ketoacidosis and reduction of the plasma glucose level, we found low free t4 level and high tsh levels. thyroid peroxidase antibodies titer was 1383 iu/ml and both gliadin and endomysial antibodies were negative. this was the first report of a child with down syndrome showing type 1 diabetes combined with ...200920012788
[effects and toxicity mechanism of 2,2',4,4'-tetrabrominated diphenyl ethers on the homeostasis of thyroid hormone system in c57bl/6 mice].to investigate the effects and of toxicity mechanism of 2,2',4,4'-tetrabde (bde-47) on tt3, tt4 and tsh in c57bl/6 mice.200919877504
[postoperative survival comparison of non-small cell lung cancer between disease with peripheral direct adjacent invasion and resectable t4 disease with mediastinal structures invasion].to determine the postoperative survival of non-small cell lung cancer with peripheral adjacent lobe invasion by comparing it with that of resectable t4 disease with mediastinal structures invasion, and hence try to find out some clue concerning how to define these patients for a reasonable t stage.200919862983
necessity of quantum coherence to account for the spectrum of time-dependent mutations exhibited by bacteriophage t4.transcriptase measurements of quantum expectations due to time-dependent coherent states populating informational dna base-pair sites, designated by g-c --> *g-*c, g-c --> g'-c', and a-t --> *a-*t, provide a model for transcription and replication of time-dependent dna lesions exhibited by bacteriophage t4. coherent states are introduced as consequences of hydrogen bond arrangement, keto-amino --> enol-imine, where product protons are shared between two sets of indistinguishable electron lone-pa ...200919882244
molecular phylogeny of acanthamoeba.after morphological grouping of acanthamoeba by pussard and pons, phylogeny of the genus has been always a big topic to the researchers. because of the variability of morphological characteristics, unchangeable and stable characters have been investigated for phylogenic criteria. isoenzyme and mitochondrial dna rflp (mt dna rflp) analyses revealed different patterns among strains assigned to a same species. therefore, these characteristics would be considered as tools for strain discrimination t ...200919885332
surgical outcomes and prognostic factors for t4 gastric cancers.in locally advanced gastric carcinomas that have invaded adjacent organs, the prognosis is poor. when combined resections are performed in t4 gastric cancers, a high morbidity rate is reported and it is inconclusive as to whether or not there is an improvement in the survival rate. we investigated surgical outcomes and analysed the prognostic factors for t4 gastric cancers.200919892622
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