Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| thyroid hormones affect the level and activity of nitric oxide synthase in rat cerebral cortex during postnatal development. | the effects of thyroid hormones (th) on the enzyme level and activity of neuronal nitric oxide synthase (nnos) were studied in the rat cerebral cortex during postnatal life. as revealed by arginine/citrulline conversion assay and western blot analysis of the homogenate of the parietal cortex t4 significantly increased nnos activity and nnos protein level to 153 +/- 25% and to 178 +/- 20%, respectively. in contrast, 6-n-propyl-2-thyouracil (ptu) decreased nnos activity and nnos level to 45 +/- 10 ... | 2008 | 17940896 |
| differences in spatial-temporal parameters and arm-leg coordination in butterfly stroke as a function of race pace, skill and gender. | spatial-temporal parameters (velocity, stroke rate, stroke length) and arm-leg coordination in the butterfly stroke were studied as a function of race pace, skill (due to technical level, age, and experience) and gender. forty swimmers (ten elite men, ten elite women, ten less-skilled men, and ten less-skilled women) performed the butterfly stroke at four velocities corresponding to the appropriate paces for the 400-m, 200-m, 100-m, and 50-m, respectively. arm and leg stroke phases were identifi ... | 2008 | 17935810 |
| association between serum tsh, free t4 and serum liver enzyme activities in a large cohort of unselected outpatients. | although overt thyroid dysfunction is associated with some liver abnormalities, there is a dearth of information on liver function tests across thyroid function tests. we assessed the relationship between serum liver enzyme activity and thyroid function tests in a cohort of adult individuals. | 2008 | 17941901 |
| evolution of the epidemiology and clinical characteristics of larynx and hypopharynx carcinoma in poland from 1991 to 2001. | a retrospective analysis was performed of 12,888 cases of larynx and hypopharynx carcinoma diagnosed in 19 ent departments in poland during an 11-year period from 1991 to 2001. an assessment of basic epidemiological data, including also tumor site and disease stage at the time of diagnosis, was conducted. epidemiological trends over the 11-year period of the analysis were examined. the average m:f proportion was 8:1, with a significant increase in the number of female patients during the analyze ... | 2008 | 17955255 |
| the involvement of thyroid hormones and cortisol in the osmotic acclimation of solea senegalensis. | the peripheral conversion of the prohormone 3,5,3',5'-tetraiodothyronine (t4) to the biologically active 3,5,3'-triiodothyronine (t3), via enzymatic deiodination by deiodinases, is an important pathway in thyroid hormone metabolism. the aim of this study was to test if thyroid hormones and cortisol, as well as the outer ring deiodination (ord) metabolic pathway, are involved in the osmoregulatory response of senegalese sole (solea senegalensis, kaup 1858). we measured osmoregulatory and endocrin ... | 2008 | 17950731 |
| polychlorinated biphenyl effects on avian hepatic enzyme induction and thyroid function. | polychlorinated biphenyls (pcbs) decrease thyroid function in laboratory rodents by inducing activity of a liver enzyme, uridine diphosphate-glucuronosyltransferase (udp-gt), thereby increasing thyroxine (t4) clearance. this loss of t4 can lead to hypothyroidism. in this study, an assay was validated for measuring udp-gt activity toward t4 in japanese quail. udp-gt induction by aroclor 1254 was evaluated in quail, and responses of quail and mice were compared. in experiment 1, japanese quail and ... | 2008 | 17950733 |
| cdna cloning and expression analysis of thyroid hormone receptor in the coho salmon oncorhynchus kisutch during smoltification. | two types of cdna clones encoding thyroid hormone receptor (tr) genes, tralpha and trbeta, were isolated from the coho salmon oncorhynchus kisutch. the two genes each consists of multiple isoforms, derived from different loci or by an alternative splicing. rt-pcr revealed a broad localization of the tralpha and trbeta transcripts that both expressed in brain, gill, liver, muscle, kidney, ovary, skin and eyeball. during the early stages of the smoltification period, the mrna level of the tr trans ... | 2008 | 17950735 |
| blood-brain barrier genomics and cloning of a novel organic anion transporter. | a novel organic anion transporter selectively expressed at the blood-brain barrier (bbb), originally designated bbb-specific anion transporter type 1 (bsat1), and now classified as slco1c1, has been cloned from a bbb genomics program as a partial cdna; this study describes the cloning and expression of the full-length cdna from a rat brain capillary cdna library. northern analysis revealed the selective expression of the transporter at the bbb, and the transporter was expressed after permanent t ... | 2008 | 17667996 |
| heart failure after aortic valve substitution due to severe hypothyroidism. | we report a case of a 70-year-old female with considerable co-morbidities (type 2 diabetes, leiden factor v mutation, mild to moderate chronic obstructive pulmonary disease) and a recent biological aortic valve substitution, who was admitted due to circulatory collapse caused by severe heart failure with an ejection fraction of 10%. the patient was treated with diuretics and inotropic drugs with only a minor effect on the condition. a thyroid status disclosed a condition of overt hypothyreosis ( ... | 2008 | 17662492 |
| postural responses during falling with rapid reach-and-grasp balance reaction in patients with motor complete paraplegia. | cross-sectional study. | 2008 | 17621310 |
| thyroid dysfunction in laryngectomees-10 years after treatment. | hypothyroidism is 1 of the complications that follow treatment of various head and neck cancers. in the literature, reviews using different primary sites and differences in treatment modalities make comparison of post-treatment hypothyroidism not possible. the objective of this study was to evaluate the incidence of hypothyroidism in a homogenous group of patients who were treated with total laryngectomy and irradiation for laryngeal carcinoma and to assess the importance of different variables ... | 2008 | 17636544 |
| developmental exposure to decabromodiphenyl ether (pbde 209): effects on thyroid hormone and hepatic enzyme activity in male mouse offspring. | decabrominated diphenyl ether (pbde 209) is the second most used brominated flame retardant (bfrs). many studies have shown that some of the bfrs act as endocrine disruptors via alterations in thyroid hormone homeostasis and affect development. little is known about the effect of prenatal exposure to pbde 209 on the development in male offspring. using a cd-1 mouse model, we attempt to estimate the possible effect of in utero exposure to pbde 209 on thyroid hormone and hepatic enzymes activities ... | 2008 | 17698168 |
| current relevance of cervical ultrasonography in staging cancer of the esophagus and gastroesophageal junction. | to evaluate the value of external ultrasonography (us) of the neck in current dedicated preoperative staging of patients with cancer of the esophagus and gastroesophageal junction (gej). | 2008 | 17681735 |
| prevention of suckling improves postpartum reproductive responses to hormone treatments in pelibuey ewes. | to determine the effects of suckling on postpartum (pp) reproductive efficiency in pelibuey ewes, two experiments were performed. in experiment 1, 112 ewes were randomly assigned to one of two groups at parturition: without restriction of suckling (wrs) 24 h day(-1) for 60 days (n=56), and weaned ewes (we), weaned at 40 days pp (n=56). on day 30 pp, all ewes were given prostaglandin (pgf2alpha) and one of four treatments (n=14): t1, intravaginal progestagen (fga; 40 mg) for 12 days from day 30 p ... | 2008 | 17669607 |
| triiodothyronine differentially regulates key metabolic factors in lean and obese cats. | the effect of a 2-week administration of 75microg triiodothyronine (t3) on substrate oxidation, heat production, non-esterified fatty acids, and leptin was evaluated in eight lean (three females and five males) and eight obese (five females and three males) age-matched adult neutered cats. in addition, using real-time rt-pcr, expression of muscle and adipose tissue uncoupling proteins (ucp2 and ucp3), deiodinase 1 and 2 (d1; d2), and peroxisome proliferator-activated receptor (ppar) alpha and ga ... | 2008 | 17683895 |
| cytokeratin 17 mrna expression has potential for diagnostic marker of oral squamous cell carcinoma. | determination of marker for identification of oral squamous cell carcinoma (oscc) is important for early diagnosis and individual therapy. cytokeratins (cks) like ck 19 and ck 20 are known to be useful diagnostic and prognostic markers for solid tumors. the aim of this study was to evaluate the relevance of further cks for diagnosis of oscc. | 2008 | 17786476 |
| flexible non-fusion scoliosis correction systems reduce intervertebral rotation less than rigid implants and allow growth of the spine: a finite element analysis of different features of orthobiom. | the orthobiom non-fusion scoliosis correction system consists of two longitudinal rods, polyaxial pedicle screws, mobile and fixed connectors and a cross-connector. the mobile connectors can move along and around the rod, thus allowing length adaptation during growth. the aim of this study was to determine the effects of different features of this novel implant on intervertebral rotations, to calculate the movement of the mobile connectors along the rods for different loading cases and to compar ... | 2008 | 17712575 |
| hypnosis in the management of persistent idiopathic orofacial pain--clinical and psychosocial findings. | this controlled and patient blinded study tested the effect of hypnosis on persistent idiopathic orofacial pain (piop) in terms of clinical and psychosocial findings. forty-one piop were randomized to active hypnotic intervention or simple relaxation as control for five individual 1-h sessions. primary outcome was average pain intensity scored three times daily in a pain diary using visual analogue scale (vas). secondary outcome measures were pain quality assessed by mcgill pain questionnaire (m ... | 2008 | 17689192 |
| supraglottic laryngectomy: analysis of 267 cases. | horizontal supraglottic laryngectomy (hsl) allows the preservation of a functioning larynx and avoids permanent tracheotomy. in this retrospective study we report our experience with hsl and describe the functional and oncological results of the procedure. a total of 267 previously untreated patients with squamous cell carcinoma of the supraglottis underwent a supraglottic laryngectomy at our department from january 1978 to may 2002. the main outcome measures were: local and regional control, di ... | 2008 | 17684753 |
| long-term efficacy of preoperative radiotherapy for locally advanced low rectal cancer. | the purpose of this study was to assess the long-term efficacy of preoperative radiotherapy for locally advanced low rectal cancer. | 2008 | 17704925 |
| translational constraint influences dynamic spinal canal occlusion of the thoracic spine: an in vitro experimental study. | mechanical constraints to spine motion can arise in a variety of real-world situations such as when shoulder belts prevent anterior translation of the thorax during automotive collisions. the effect of such constraint on spinal column-spinal cord interaction during injury remains unknown. the purpose of the present study was to compare maximal dynamic spinal canal occlusion, measured via a specialized transducer, in cadaveric upper thoracic spine specimens under a variety of anterior-posterior c ... | 2008 | 17709110 |
| higher glucose uptake in paralysed spastic leg. | insulin resistance and diabetes mellitus have been reported in the spinal cord injured (sci). the group exhibits risk factors, as decreased physical activity, as well as episodes of stimulation of sympathetic nervous system below the level of lesion known to stimulate lipolysis, which in turn could induce insulin resistance. however, data are inconsistent, which might indicate the presence of protective mechanisms. | 2008 | 17579617 |
| relationship between leptin content, metabolic hormones and fat deposition in three beef cattle breeds. | the aim of the study was to determine if cattle breeds differing in their carcass characteristics also differ in the profiles of their leptin and metabolic hormones. three breeds, belgian blue (bb) (n=12), limousin (l) (n=12) and aberdeen angus (aa) (n=12) with varying ability to deposit fat and protein were compared. blood, muscle and subcutaneous (sc) adipose tissue were sampled. animal performance, carcass and meat characteristics were determined as well as plasma leptin concentration, leptin ... | 2008 | 17569563 |
| inverse relationship between vertebral fractures and spine osteoarthritis in postmenopausal women with osteoporosis. | although the coexistence of osteoarthritis and osteoporosis is considered as uncommon, it has been suggested that, in postmenopausal women, disc space narrowing increases the risk of vertebral fracture. the aim of this study was to check this hypothesis in postmenopausal women with osteoporosis. | 2008 | 17557888 |
| idiopathic spinal epidural lipomatosis without obesity: a case with relapsing and remitting course. | case report of a rare form of idiopathic spinal epidural lipomatosis (sel) manifesting with relapsing and remitting course. | 2008 | 17607308 |
| purification and concentration of bacteriophage t4 using monolithic chromatographic supports. | phages are gaining importance due to their wide usage. in this work strong anion exchange monolithic chromatographic column was used for single step phage purification. most of the proteins and dna were removed and recovery of approximately 70% of infective virus was reproducibly achieved. 30 ml of phage sample was purified in around 10 min. | 2008 | 17588505 |
| local progression among men with conservatively treated localized prostate cancer: results from the transatlantic prostate group. | men with clinically detected localized prostate cancer treated without curative intent are at risk of complications from local tumor growth. we investigated rates of local progression and need for local therapy among such men. | 2008 | 17544572 |
| effect of neoadjuvant epirubicin and total androgen blockade on complete pathological response in patients with clinical stage t3/t4 prostate cancer. | most patients with stage t3-t4 prostate cancer experience disease relapse despite radiation and/or hormonal therapy, and their management remains controversial. we investigated the feasibility of, and the pathological response induced by neoadjuvant chemo-hormonal treatment in men with clinical stage t3/t4. | 2008 | 17502132 |
| the relation between reduced serum melatonin levels and zinc in rats with induced hypothyroidism. | the objective of the study was to explore the changes in melatonin and zinc levels in rats with induced hypothyroidism. thirty adult male rats used in the study were allocated to three groups with equal numbers. group 1: general control group which was not subjected to any procedure. group 2: sham-hypothyroidism group to which was administered 10 mg kg(-1) intraperitoneal (i.p.) physiologic saline (0.09% nacl) for 4 weeks. group 3: hypothyroidism group which was supplemented with intraperitoneal ... | 2008 | 17094164 |
| expression of the bacteriophage t4 lysozyme gene in tall fescue confers resistance to gray leaf spot and brown patch diseases. | tall fescue (festuca arundinacea schreb.) is an important turf and forage grass species worldwide. fungal diseases present a major limitation in the maintenance of tall fescue lawns, landscapes, and forage fields. two severe fungal diseases of tall fescue are brown patch, caused by rhizoctonia solani, and gray leaf spot, caused by magnaporthe grisea. these diseases are often major problems of other turfgrass species as well. in efforts to obtain tall fescue plants resistant to these diseases, we ... | 2008 | 17273914 |
| validity and reliability of active shape models for the estimation of cobb angle in patients with adolescent idiopathic scoliosis. | choosing the most suitable treatment for scoliosis relies heavily on accurate and reproducible cobb angle measurement from successive radiographs. the objective is to reduce variability of cobb angle measurement by reducing user intervention and bias. custom software to increase automation of the cobb angle measurement from posteroanterior radiographs was developed using active shape models. validity and reliability of the automated system against a manual and semiautomated measurement method wa ... | 2008 | 17340228 |
| long level (t4-l1) spinal epidural abscess in a diabetic patient - a case report -. | spinal epidural abscesses are uncommon, but potentially devastating and often fatal. they can be found in normal patients, but they are more prevalent in immunocompromised patients, such as intravenous drug users, diabetics, chronic renal failure patients, pregnant women, and others. timely diagnosis and treatment are the keys to optimizing outcome. traditionally, treatment has comprised parenteral antibiotics and possible surgical intervention, such as decompression by pus drainage. we treated ... | 2008 | 20411144 |
| treatment results of adults and children with medulloblastoma nci, cairo university experience. | to evaluate treatment outcome and prognostic factors of adults and pediatric medulloblastoma patients treated by adjuvant postoperative craniospinal irradiation (csi) and chemotherapy. | 2008 | 20029474 |
| [gonadal and thyroid function after treatment for hodgkin's lymphoma in adolescents]. | complete treatment for hodgkin's lymphoma (hl) may disturb functioning of different organs leading to deteriorated quality of future life. endocrine complications are one of the most common and may be the result of radiotherapy of neck, mediastinal and infradiaphragmatic regions, as well as chemotherapy, especially with alkylating agents. the aim of our study was to analyse gonadal and thyroid disturbances in young adults after the treatment for hl in childhood. | 2008 | 19531819 |
| treatment of locally advanced and metastatic bladder cancer. | there is a significant variation in the treatment strategies adopted for the treatment of locally advanced t3b, t4a, n1-3 and metastatic bladder cancer. there is increasing evidence that we would be able to offer them some benefit in terms of disease-free survival and improving the quality of life. this article is aimed at reviewing the current literature on the treatment strategies in locally advanced and metastatic bladder cancer. | 2008 | 19468366 |
| surgical approach in patients with t4 bladder cancer as primary treatment: disaster or option with improved quality of life. | whereas local control is often insufficient in conservative management of t4 bladder cancer, neoadjuvant chemotherapy delays definite treatment, which could result in increased therapy-associated morbidity and mortality during the course of the disease. primary cystectomy has been reported to be associated with a high complication rate and unsatisfactory clinical efficacy. herein, we report postoperative outcome in 21 t4 bladder cancer patients subjected to primary cystectomy. | 2008 | 19468367 |
| provisional clinical chemistry parameters in the african sharptooth catfish (clarias gariepinus). | pollution affects aquatic systems worldwide and there is an urgent need for efficient monitoring. fish are generally sensitive to their environment and are thus considered to be valuable bioindicator species. the african sharptooth catfish (clarias gariepinus) is particularly important in this respect because of its very wide distribution. in order to use c. gariepinus as a bioindicator species its baseline clinical chemistry must be defined. existing data are scarce, and the objective of this w ... | 2008 | 19496313 |
| thyroid hormone: a "prime suspect" in human immunodeficiency virus (hiv/aids) patients? | acquired immunodeficiency syndrome (aids) is the final and most serious stage of the disease caused by human immunodeficiency virus. the immune system is the target of aids. we investigate presently any possible involvement of thyroid hormone, the deficiency of which gives rise to oedema and susceptibility to nonspecific infections; with a view to finding the primary factor seeding the disease. it has been reported that circumcision reduced the incidence of hiv/aids infection. beyond circumcisio ... | 2008 | 19434216 |
| [results of alginate and hypertonic solution in wound healing of head and neck cancers]. | in head and neck cancers, complications such as pharyngostoma, orostoma, or fistula can present following surgery or surgery after irradiation. | 2008 | 19408512 |
| [surgical treatment place in the management of prostate cancer: report of 96 cases]. | the goal of this study is to access the surgical management of the prostate cancer. | 2008 | 19634545 |
| [analysis of blood hormone levels in boys of prepubertal and pubertal age with epilepsy treated with different antiepileptic drugs]. | thirty-nine boys with epilepsy, aged 8-17 years, and 61 sex- and age-matched controls have been examined. changes of blood hormone levels were found in patients received carbamazepines, valproates, polytherapy as well as in non-treated patients. the increase of levels of progesterone, testosterone, fsh and lh, decrease of prolactin and estradiol levels and influence on thyroid gland hormones, as reflected by increasing of t4 and decreasing of t3 compared to carbamazepines, were found during the ... | 2008 | 19618713 |
| identification of viruses using microfluidic protein profiling and bayesian classification. | we present a rapid method for the identification of viruses using microfluidic chip gel electrophoresis (cge) of high-copy number proteins to generate unique protein profiles. viral proteins are solubilized by heating at 95 degrees c in borate buffer containing detergent (5 min), then labeled with fluorescamine dye (10 s), and analyzed using the microchemlab cge system (5 min). analyses of closely related t2 and t4 bacteriophage demonstrate sufficient assay sensitivity and peak resolution to dis ... | 2008 | 19551975 |
| a study on endocrine dysfunction in thalassaemia. | the aim was to study the prevalence and severity of hormonal imbalance affecting growth, gonadal and thyroid function in thalassaemic patients and to find out whether any correlation exists between the degree of tissue iron-overload and several patients characteristics like age, gender, foetal haemoglobin (hbf) level, type of thalassaemia (beta or e-beta), and the presence of specific endocrine abnormality. sixty-eight consecutive non-chelated, transfusion-dependent patients of beta and e-beta-t ... | 2008 | 19552099 |
| selenium and thyroid autoimmunity. | the trace element selenium (se) occurs in the form of the amino acid selenocysteine in selenoproteins. selenoproteins exerts multiple physiological effects in human health, many of which are related with regulation of reduction-oxidation processes. in fact, the selenoenzyme families of glutathione peroxidase (gpx) and thioredoxin reductase (trx) display the ability to act as antioxidants, protecting cells from oxidative damage. furthermore, another class of selenoproteins are the iodothyronine d ... | 2008 | 19707359 |
| receptor interactions by polybrominated diphenyl ethers versus polychlorinated biphenyls: a theoretical structure-activity assessment. | the extensive body of literature regarding the interaction of polychlorinated biphenyls (pcbs) with transcription factors (receptors) has great value to understand similarities and distinctions and in formulating hypotheses regarding the activity of polybrominated diphenyl ethers (pbdes) toward those same receptors. our goal is to present the most comprehensive overview of pbde effects on ahr, car, pxr, er, ar, pr, dht, th, t3, t4 and igf, as well as hypothetical biological activities of ppar, r ... | 2008 | 19768137 |
| meat quality of argentinean "camperos" chicken enhanced in omega-3 and omega-9 fatty acids. | five diets were assessed with the aim of increasing oleic fatty acid and omega-3 polyunsaturated fatty acid content in 'campero' poultry meat and evaluating their influence on sensory attributes. animals from treatment 1 (t1) were confined and fed with corn/soybean diet; in t2, animals were fed with a corn/soybean mix with free access to pasture; t3 diet had high oleic sunflower seeds (hoss) and linseeds with access to pasture; t4 diet was similar to t2 with free access to chicory instead of pas ... | 2008 | 22062903 |
| effects of feeding strategies including different proportion of pasture and concentrate, on carcass and meat quality traits in uruguayan steers. | eighty four steers were randomly assigned to three pasture treatments with increasing levels of grain (t1: 0%; t2: 0.6%; t3: 1.2% of live weight) and to an ad libitum concentrate treatment, t4, to study the effects on carcass and meat quality. animals were slaughtered with 500 kg of average live weight per treatment. average daily gain increased with increasing levels of energy, determining different slaughter dates. intermediate treatments showed higher carcass weight than t1. t4 and t3 had a h ... | 2008 | 22063593 |
| advances in patient safety: new directions and alternative approaches (vol. 3: performance and tools) | objective: maintenance of competence in orotracheal intubation skills is challenging for non-anesthesiologists who do not practice intubation routinely. we hypothesized that discipline, recent training, and experience would affect immediate skill improvement during refresher training. methods: experienced pediatric providers refreshed intubation skills in six simulated infant trauma scenarios with cervical spine protection. time (t) to successful intubation (in seconds) was used to calculate ref ... | 2008 | 21249918 |
| beef lipids in relation to animal breed and nutrition in argentina. | fatty acid (fa) composition of intramuscular fat (imf) in m. longissimus dorsi (ld) was measured in 72 steers from angus (a), charolais×angus (cha×a) and holstein argentine (ha) breeds. the steers were allotted to four dietary treatments of six animals each: t1, steers grazed on pasture; t2, steers supplemented with cracked corn grain (0.7% of live-weight) daily and free access to pasture; t3, steers supplemented with cracked corn grain (1% of live-weight) daily and free access to pasture; and t ... | 2008 | 22062910 |
| stretching dna in polymer nanochannels fabricated by thermal imprint in pmma. | we present results regarding the fast and inexpensive fabrication of polymer biochips for investigating the statics and dynamics of dna confined in nanochannels. the biochips have been fabricated by means of nanoimprint lithography (nil) in low molecular weight polymethyl methacrylate (pmma) using a 4-áinch diameter two-level hybrid stamp. the fluidic structures were sealed using thermal polymer fusion bonding. the stamp has nanometer--áand micrometer-sized protrusions defined in a thermally gro ... | 2008 | 21817722 |
| successful downstaging of high rectal and recto-sigmoid cancer by neo-adjuvant chemo-radiotherapy. | the benefit of neoadjuvant therapy for tumours above the peritoneal reflection is not clear. the purpose of this study is to demonstrate the feasibility and downstaging of treating locally advanced tumours from high rectum to distal sigmoid with preoperative chemoradiotherapy (crt). | 2008 | 21892276 |
| thyroid hormones and the central nervous system of mammals (review). | the thyroid hormones (ths) l-thyroxine (t4) and l-triiodothyronine (t3) have a profound influence on the development and maturation of the mammalian brain, both before and after birth. any impairment in the supply of ths to the developing nervous system leads to severe and irreversible changes in both the overall architecture and functions of the brain and causes, in humans, neurological and motor deficits known as cretinism. pronounced neurological symptoms are also commonly observed in adult p ... | 2008 | 21479409 |
| proteomic-based approach for biomarkers discovery in early detection of invasive urothelial carcinoma. | identification of reliable non-invasive markers for the detection of invasive phenotype of urothelial carcinoma is needed. this study characterizes and compares protein expression profiles of adjacent non-neoplastic urothelium and invasive urothelial carcinoma to identify biomarkers for early detection of de novo bladder cancer. differences in protein expression between adjacent non-neoplastic and high-grade, stage t4, grade 3 invasive urothelial carcinoma tissues were investigated using 2-de, m ... | 2008 | 21136781 |
| decreasing enterobacter sakazakii (cronobacter spp.) food contamination level with bacteriophages: prospects and problems. | enterobacter sakazakii (cronobacter spp.) is an opportunistic pathogen, which can cause rare, but life-threatening infections in neonates and infants through feeding of a contaminated milk formula. we isolated 67 phages from environmental samples and tested their lytic host range on a representative collection of 40 e. sakazakii strains. a cocktail of five phages prevented the outgrowth of 35 out of 40 test strains in artificially contaminated infant formula. two e. sakazakii phages represented ... | 2008 | 21261874 |
| a randomized clinical trial comparing breakfast and bedtime administration of insulin glargine in children and adolescents with type 1 diabetes. | background: insulin glargine provides effective glycemic control when administered at bedtime in adults.objective: this study aims to investigate whether insulin glargine is equally effective if administered in the morning or at bedtime in combination with preprandial anologue insulin.methods: twenty-eight patients that have been treated with an intensified insulin regimen for at least one year were randomized to insulin glargine injection at breakfast (06:00-09:00) (12 patients) or bedtime (21: ... | 2008 | 21318060 |
| the course of anxiety and depression in patients with breast cancer and gynaecological cancer. | background/aims: the aim of this study was to assess the course of anxiety and depression in cancer patients over time and to detect determinants of the changes in the scores. patients and method: women with breast cancer and gynaecological cancer (n = 367) were tested at the beginning (t1) and at the end (t2) of treatment in the hospital, 6 months later (t3), and 12 months later (t4), using the hospital anxiety and depression scale (hads). results: anxiety and depression were highest at the sta ... | 2008 | 21048913 |
| [detection of cea mrna on non-small lung cancer and it's significance.]. | in recent years, many studies on micrometastasis in non-small cell lung cancer (nsclc) have been reported, this study is to investigate the effect of operation on micrometastasis from nsclc and evaluate the relation between micrometastasis and clincopathological parameters. | 2008 | 20738920 |
| preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: nsabp r-03. | although chemoradiotherapy plus resection is considered standard treatment for operable rectal carcinoma, the optimal time to administer this therapy is not clear. the nsabp r-03 (national surgical adjuvant breast and bowel project r-03) trial compared neoadjuvant versus adjuvant chemoradiotherapy in the treatment of locally advanced rectal carcinoma. | 2009 | 19770376 |
| phage t4 mobe promotes trans homing of the defunct homing endonuclease i-teviii. | homing endonucleases are site-specific dna endonucleases that typically function as mobile genetic elements by introducing a double-strand break (dsb) in genomes that lack the endonuclease, resulting in a unidirectional gene conversion event that mobilizes the homing endonuclease gene and flanking dna. here, we characterize phage t4-encoded mobe, a predicted free-standing hnh family homing endonuclease. we show that mobe is promoterless and dependent on upstream transcription for expression, and ... | 2009 | 19773422 |
| diagnostic performance of 64-mdct and 1.5-t mri with high-resolution sequences in the t staging of gastric cancer: a comparative analysis with histopathology. | this study was undertaken to compare the accuracy of magnetic resonance (mr) imaging and 64-slice multidetector computed tomography (64-mdct) in the t staging of gastric carcinoma in comparison with histopathology. | 2009 | 19774440 |
| [effect of initial substrate concentrations and ph on hydrogen production from xylose with clostridium butyricum t4]. | we studied the effect of initial ph and substrate concentrations on the conversion of xylose to hydrogen by clostridium butyrium t4 at ph 5.0-8.5 and substrate concentrations 5-40 g/l. the cumulative hydrogen volume and the specific hydrogen production rate increased and then decreased with increasing initial ph or substrate concentrations. at initial ph 6.5 and substrate concentration 20 g/l, the cumulative hydrogen production and the specific hydrogen production rate reached the maximum value ... | 2009 | 19777817 |
| [malignant tumors of auricula and periauricular area]. | malignant tumors of auricula and periauricular area represent seven percent of all cutaneous tumors. they appear mostly in the sixth and seventh decade. according to histological type they are basocellular and planocellular carcinomas. the most frequent etiology is the sun exposition. the aim of this study was to analyze clinical and histological characteristics and therapy of malignant tumors of auricular and periauricular area. | 2009 | 19780414 |
| [surgical treatment of ipsilateral multi-focal non-small cell lung cancer]. | the staging and treatment of multi-focal non-small cell lung cancer (nsclc) are controversial. this study evaluated the effectiveness of surgical treatment for the ipsilateral multi-focal nsclc. | 2009 | 19781266 |
| [prognostic analysis of n2 non-small cell lung cancer]. | to evaluate the surgical therapeutic strategy and prognostic factors for non-small cell lung cancer (nsclc) with mediastinal lymph node metastasis (n2). | 2009 | 19781268 |
| predicting ligand binding affinity with alchemical free energy methods in a polar model binding site. | we present a combined experimental and modeling study of organic ligand molecules binding to a slightly polar engineered cavity site in t4 lysozyme (l99a/m102q). for modeling, we computed alchemical absolute binding free energies. these were blind tests performed prospectively on 13 diverse, previously untested candidate ligand molecules. we predicted that eight compounds would bind to the cavity and five would not; 11 of 13 predictions were correct at this level. the rms error to the measurable ... | 2009 | 19782087 |
| external radiotherapy for prostate cancer with or without androgen deprivation: geneva, 1991 to 2004. | questions under study/principles: a retrospective assessment of long-term results on a single centre, single author experience in treating prostate cancer with high dose curative radiotherapy (rt) with or without androgen deprivation (ad). | 2009 | 19736590 |
| effects of photo stimulation and nonstimulation of golden hamsters (mesocricetus auratus) from birth to early puberty on testes structure and function. | we tested whether puberty in golden hamsters is photoperiodically controlled. hamsters were raised under 14:10 hours light:dark (14l) and 1:23 hours light:dark (1l) respectively, from birth to 28 days and tested for various parameters. body weight, leydig cell (lc) size and testicular testosterone secretion were greater and plasma thyroxin (t4), testicular androstenedione secretion and lc number were lower (p<0.05) in 1l than 14l hamsters. volumes of testicular components were similar in the two ... | 2009 | 19760591 |
| effects of feed supplementation with specific hen egg yolk antibody (immunoglobin y) on salmonella species cecal colonization and growth performances of challenged broiler chickens. | anti-salmonella spp. egg yolk antibodies (igy) simultaneously directed against salmonella enteritidis and salmonella typhimurium were tested to determine if their inclusion in feed decreased salmonella spp. cecal colonization in experimentally infected broiler chickens. egg yolk powder (eyp) was obtained by freeze-drying egg yolks containing anti-salmonella spp. immunoglobin y was included in feed at 5 levels of concentration (0 to 5%). feeds were formulated to similar nutrient levels and provid ... | 2009 | 19762860 |
| simple, rapid zebrafish larva bioassay for assessing the potential of chemical pollutants and drugs to disrupt thyroid gland function. | thyroid function may be altered by a very large number of chemicals routinely found in the environment research evaluating potential thyroid disruption is ongoing, but there are thousands of synthetic and naturally occurring drugs and chemicals to be considered. european and united states policies call for the development of simple methodologies for screening endocrine-disrupting chemicals. zebrafish are widely used as a model organism for assessing drug effects because of their small size, high ... | 2009 | 19764258 |
| treatment of thoraco-lumbar curves in adolescent females affected by idiopathic scoliosis with a progressive action short brace (pasb): assessment of results according to the srs committee on bracing and nonoperative management standardization criteria. | the effectiveness of conservative treatment of scoliosis is controversial. some studies suggest that brace is effective in stopping curve progression, whilst others did not report such an effect.the purpose of the present study was to effectiveness of progressive action short brace (pasb) in the correction of thoraco-lumbar curves, in agreement with the scoliosis research society (srs) committee on bracing and nonoperative management standardisation criteria. | 2009 | 19765288 |
| pattern of use of adjuvant chemotherapy for stage ii colon cancer: a single-institution experience. | american society of clinical oncology (asco) guidelines define high-risk prognostic features (hrfs) in stage ii colon cancer and recommend limiting adjuvant chemotherapy to patients with hrfs. we evaluated the extent to which hrfs influenced decisions on adjuvant chemotherapy before and after publication of the guidelines. | 2009 | 19739270 |
| peripheral blood t4 cell surface ccr5 density as a marker of activity in rheumatoid arthritis treated with anti-cd20 monoclonal antibody. | the chemokine (c-c motif) receptor ccr5 and its ligand ccl5 play key roles in the intra-articular recruitment of peripheral blood mononuclear cells (pbmc) in rheumatoid arthritis (ra). therefore, using quantitative cytofluorometry, we followed t4 cell surface ccr5 density in 27 subjects with ra before and after treatment with the anti-cd20 monoclonal antibody rituximab. we observed low t4 cell surface ccr5 densities before treatment, which correlated positively with disease activity, as determin ... | 2009 | 19740335 |
| population-based studies of antithyroid drugs and sudden cardiac death. | thyroid free t4 is associated with qtc-interval prolongation, which is a risk factor for sudden cardiac death (scd). hyperthyroidism has been associated with scd in case reports, but there are no population-based studies confirming this. the aim was to investigate whether use of antithyroid drugs (as a direct cause or as an indicator of poorly controlled hyperthyroidism) is associated with an increased risk of scd. | 2009 | 19740403 |
| current management of esophageal squamous-cell carcinoma in japan and other countries. | the incidence of adenocarcinoma of the distal esophagus or esophagogastric junction has increased considerably in western countries during the past 3 decades, whereas the incidence of squamous-cell carcinoma has decreased slightly. in japan, most esophageal cancers are squamous-cell carcinomas. endoscopic examinations are more frequently performed in japan for routine screening and diagnosis and treatment than in other countries, thereby increasing the detection rate of superficial esophageal ca ... | 2009 | 19742141 |
| thyroid hormone interactions with dmpc bilayers. a molecular dynamics study. | the structure and dynamics of thyroxine (t4), distal and proximal conformers of 3',3,5-triiodo-l-thyronine (t3d and t3p), and 3,5-diiodo-l-thyronine (t2) upon interaction with dmpc membranes were analyzed by means of molecular dynamics simulations. the locations, the more stable orientations, and the structural changes adopted by the hormones in the lipid medium evidence that the progressive iodine substitution on the beta ring lowers both the possibility of penetration and the transversal mobil ... | 2009 | 19743839 |
| domain insertion effectively regulates the mechanical unfolding hierarchy of elastomeric proteins: toward engineering multifunctional elastomeric proteins. | the architecture of elastomeric proteins controls fine-tuned nanomechanical properties of this class of proteins. most elastomeric proteins are tandem modular in structure, consisting of many individually folded domains of varying stability. upon stretching, these elements unfold sequentially following a strict hierarchical pattern determined by their mechanical stability, where the weakest element unfolds first and the strongest unfolds last. although such a hierarchical architecture is well-su ... | 2009 | 19746906 |
| changes in the central component of the hypothalamus-pituitary-thyroid axis in a rabbit model of prolonged critical illness. | prolonged critically ill patients reveal low circulating thyroid hormone levels without a rise in thyroid stimulating hormone (tsh). this condition is labeled "low 3,5,3'-tri-iodothyronine (t3) syndrome" or "nonthyroidal illness syndrome (nti)" or "euthyroid sick syndrome". despite the low circulating and peripheral tissue thyroid hormone levels, thyrotropin releasing hormone (trh) expression in the hypothalamus is reduced and it remains unclear which mechanism is responsible. we set out to stud ... | 2009 | 19747372 |
| food restriction in young japanese quails: effects on growth, metabolism, plasma thyroid hormones and mrna species in the thyroid hormone signalling pathway. | young birds, in their post-natal growth period, may reduce their growth and metabolism when facing a food shortage. to examine how such responses can be mediated by endocrine-related factors, we exposed japanese quail chicks to food restriction for either 2 days (age 6-8 days) or 5 days (age 6-11 days). we then measured growth and resting metabolic rate (rmr), and circulating 3,3',5-triiodo-l-thyronine (t3) and 3,5,3',5'-tetraiodothyronine (t4) levels as well as expression patterns of genes invo ... | 2009 | 19749098 |
| a paradoxical difference in relationship between anxiety, depression and thyroid function in subjects on and not on t4: findings from the hunt study. | there have been conflicting reports on the relationship between thyroid function and mood between studies in subjects on t4 and the general population not on t4. we investigated this relationship in a large catchment area-based study. | 2009 | 19751298 |
| conformational transition of giant dna in a confined space surrounded by a phospholipid membrane. | it has been established that a long dna molecule exhibits a large discrete conformational change from a coiled state to a highly folded state in aqueous solution, depending on the presence of various condensing agents such as polyamines. in this study, t4 dna labeled with fluorescent dyes was encapsulated in a cell-sized microdroplet covered with a phospholipid membrane to investigate the conformational behavior of a dna molecule in such a confined space. fluorescence microscopy showed that the ... | 2009 | 19751673 |
| effects of short-term hyper- and hypoprolactinaemia on hormones of the pituitary, gonad and -thyroid axis and on semen quality in male beagles. | effects of a short-term hyper- and hypoprolactinaemia on serum concentrations of lh, testosterone and semen quality in six male beagles were investigated. blood samples were collected at 3-day intervals for 12 weeks. the time span was divided into five 3-week periods: pre-treatment, metoclopramide (mcp) treatment (0.2 mg/kg orally three times daily), cabergoline (cab) treatment (5 microg/kg orally once daily), post-treatment 1 and post-treatment 2. in the latter, only semen characteristics were ... | 2009 | 19754595 |
| concordance with nccn colorectal cancer guidelines and asco/nccn quality measures: an nccn institutional analysis. | the national comprehensive cancer network (nccn) outcomes database was created to assess concordance to evidence- and consensus-based guidelines and to measure adherence to quality measures on an ongoing basis. the colorectal cancer database began in 2005 as a collaboration among 8 nccn centers. | 2009 | 19755049 |
| radiotherapy for t1 and t2 laryngeal cancer: the dalhousie university experience. | to report outcomes of definitive radiotherapy for early-stage squamous cell carcinoma of the larynx. | 2009 | 19755083 |
| clinical evaluation of minimized extracorporeal circulation in high-risk coronary revascularization: impact on air handling, inflammation, hemodilution and myocardial function. | we examined intraoperative microembolic signals (gme), inflammatory response, hemolysis, perioperative regional cerebral oxygen saturation (rso(2)), myocardial protection and desorbed protein amount on oxygenator fibers in high-risk patients undergoing coronary revascularization (cabg) with minimized and conventional cardiopulmonary bypass (cpb). | 2009 | 19755462 |
| the effect of lmwh (nadroparin) on tumor progression. | recent clinical studies on patients with malignancies, who were treated with uhf and lmwhs raised the possibility, that these agents may possess an inhibitory effect on tumor progression. further studies supported that this effect is independent from the anticoagulant and antithrombotic action. in this retrospective study oncological patients with an increased risk for thromboembolism were choosen, who received prophylactic treatment with an lmwh (nadroparin) at least for 6 months. comparing wit ... | 2009 | 19757196 |
| location of the primary tumor is not an independent predictor of cancer specific mortality in patients with upper urinary tract urothelial carcinoma. | the prognostic significance of renal pelvis vs ureteral upper urinary tract urothelial carcinoma tumor location is controversial. we assessed the prognostic significance of upper urinary tract urothelial carcinoma tumor location in a large, population based data set. | 2009 | 19758662 |
| adjuvant treatment with thyrotropin alpha for remnant ablation in thyroid cancer. | various studies have demonstrated the safety and efficacy of recombinant human thyroid-stimulating hormone (rhtsh) for radioiodine remnant ablation. on this basis, rhtsh was approved in europe for the radioiodine ablation of low-risk differentiated thyroid cancer (dtc) during thyroid hormone therapy with l-thyroxine (l-t4). moreover, in december 2007, the us federal drug administration approved the use of rhtsh for adjuvant treatment with radioiodine in patients with dtc without evidence of meta ... | 2009 | 19707391 |
| prognosis of pn3 stage gastric cancer. | the aim of this study was to determine the prognosis of pn3 stage gastric cancer patients after they have undergone curative resection, and we also wanted to identify the prognostic factors according to the clinico-pathologic features. | 2009 | 19707504 |
| non-canonical rna arrangement in t4-even phages: accommodated ribosome binding site at the gene 26-25 intercistronic junction. | translational initiation region of bacteriophage t4 gene 25 contains three potential shine and dalgarno sequences: sd1, sd2 and sd3. mutational analysis has predicted that an mrna stem-loop structure may include sd1 and sd2, bringing the most typical sequence sd3, gagg, to the initiation codon. here, we report physical evidence demonstrating that previously predicted mrna stem-loop structure indeed exists in vivo during gene 25 expression in t4-infected escherichia coli cells. the second mrna st ... | 2009 | 19708923 |
| contemporary risk profile of prostate cancer in the united states. | national-level data that characterize contemporary prostate cancer patients are limited. we used 2004-2005 data from the surveillance, epidemiology, and end results program to generate a contemporary profile of prostate cancer patients (n = 82 541) and compared patient characteristics of this 2004-2005 population with those of patients diagnosed in 1998-1989 and 1996-1997. among newly diagnosed patients in 2004-2005, the majority (94%) had localized (ie, stage t1 or t2) prostate cancer and a med ... | 2009 | 19713548 |
| [severe pulmonary hypertension and congestive heart failure in an elderly patient with basedow's disease]. | an 83-year-old woman was admitted to our hospital with dyspnea. a chest x-ray showed cardiomegaly and pulmonary congestion. an echocardiogram revealed severe tricuspid regurgitation and markedly elevated transtricuspid pressure gradient of 103 mmhg. there was no left ventricular systolic or diastolic dysfunction. laboratory evaluation revealed elevated free t4 and suppressed tsh levels. serum level of anti-tsh receptor antibody was significantly elevated. a thyroid echogram demonstrated increase ... | 2009 | 19713670 |
| detection of functional modes in protein dynamics. | proteins frequently accomplish their biological function by collective atomic motions. yet the identification of collective motions related to a specific protein function from, e.g., a molecular dynamics trajectory is often non-trivial. here, we propose a novel technique termed "functional mode analysis" that aims to detect the collective motion that is directly related to a particular protein function. based on an ensemble of structures, together with an arbitrary "functional quantity" that qua ... | 2009 | 19714202 |
| effect of sympathectomy level on the incidence of compensatory hyperhidrosis after sympathectomy for palmar hyperhidrosis. | palmar hyperhidrosis can be psychosocially devastating. sympathectomy provides effective treatment. the most common side effect after sympathectomy is compensatory hyperhidrosis, which can be debilitating. controversy exists as to which and how many levels treated carry the lowest incidence of compensatory hyperhidrosis after sympathectomy for palmar hyperhidrosis. | 2009 | 19698838 |
| hypoxia in larynx carcinomas assessed by pimonidazole binding and the value of ca-ix and vascularity as surrogate markers of hypoxia. | tumour hypoxia as driving force in tumour progression and treatment resistance has been well established. assessment of oxygenation status of tumours may provide important prognostic information and improve selection of patients for treatment. in this study, a large homogenous group of 103 laryngeal carcinomas has been investigated in the presence of hypoxia by pimonidazole binding and the usefulness of carbonic anhydrase ix (ca-ix) and vascular parameters as surrogate markers of hypoxia. these ... | 2009 | 19699082 |
| in vivo replication of t4 and t7 bacteriophages in germ-free mice colonized with escherichia coli. | the gut transit of t4 phages was studied in axenic mice mono-colonized with the non-pathogenic escherichia coli strain k-12. thirty minutes, 1 and 2 h after phage feeding, t4 phage had reached the jejunum, ileum and cecum, respectively. phage was found in the lumen and was also associated with the mucosa. one day later no phage was detected in the feces. compared to germ-free control animals, oral t4 phage led to a 300-fold higher fecal phage titer in mice mono-colonized with e. coli strain wg-5 ... | 2009 | 19699505 |
| investigation of stoichiometry of t4 bacteriophage helicase loader protein (gp59). | the t4 bacteriophage helicase loader (gp59) is one of the main eight proteins that play an active role in the replisome. gp59 is a small protein (26 kda) that exists as a monomer in solution and in the crystal. it binds preferentially to forked dna and interacts directly with the t4 helicase (gp41), single-stranded dna-binding protein (gp32), and polymerase (gp43). however, the stoichiometry and structure of the functional form are not very well understood. there is experimental evidence for a h ... | 2009 | 19700405 |
| expression of trpc6 in benign and malignant human prostate tissues. | we investigated the expression of transient receptor potential canonical 6 (trpc6) protein in benign and malignant human prostate tissues and in prostate cancer cell lines and the association with the stage, grade and androgen responsiveness of the tumors. immunohistochemical techniques, western blot and reverse transcription polymerase chain reaction (rt-pcr) were used to investigate trpc6 expression. trpc6 protein was detected in 9 of 20 (45.0%) of benign prostatic hyperplasia (bph) cases, and ... | 2009 | 19701218 |
| [effect of shenfu injection on the stability of circulation during induction of general anesthesia for aged people]. | to observe the intervention of shenfu injection (sfi) on the hemodynamics and circulatory function during induction of general anesthesia for aged people, in order to optimize the medication of anesthesia inductive phase in aged people. | 2009 | 19702078 |
| [effects of preconditioning and postconditioning with shenfu injection on cognitive function in patients after valve replacement under cardiopulmonary bypass]. | to investigate the effects of preconditioning and postconditioning with shenfu injection (sfi) on cognitive function in patients after valve replacement under extra-corporeal circulation. | 2009 | 19702079 |
| why are pretreatment prostate-specific antigen levels and biochemical recurrence poor predictors of prostate cancer survival? | the value of pretreatment (initial) prostate-specific antigen (ipsa) and biochemical recurrence (br) as prognostic factors for survival remains unclear. the authors sought to determine why using randomized trial data with 7-year minimum follow-up. | 2009 | 19691097 |