Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| new insight into the recognition of branched dna structure by junction-resolving enzymes. | junction-resolving enzymes are nucleases that exhibit structural selectivity for the four-way (holliday) junction in dna. in general, these enzymes both recognize and distort the structure of the junction. new insight into the molecular recognition processes has been provided by two recent co-crystal structures of resolving enzymes bound to four-way dna junctions in highly contrasting ways. t4 endonuclease vii binds the junction in an open conformation to an approximately flat binding surface wh ... | 2008 | 18160275 |
| analysis of actinomycin d treated cattle oocytes and their use for somatic cell nuclear transfer. | the present work aimed to evaluate the transcription and replication inhibitor, actinomycin d, for oocyte chemical enucleation. cattle oocytes matured in vitro were treated with actinomycin d according to the following treatments: t1, control; t2=1.0 microg/ml for 16 h; t3=1.0 microg/ml for 14 h; t4=2.5 microg/ml for 14 h; t5=5.0 microg/ml for 14 h. the oocytes were denuded and activated during 24-26 h of maturation. oocytes were fixed to determine the maturation status and for chromosome morpho ... | 2008 | 18162337 |
| resected synchronous primary malignant lung tumors: a population-based study. | synchronous lung tumors with a histology indicating primary lung carcinomas detected preoperatively or at surgery may represent intrapulmonary metastases from a primary tumor or two or more simultaneously occurring primary tumors. the situation is rare. this study was conducted to assess the characteristics and outcome for this patient group. | 2008 | 18154811 |
| is fledging in king penguin chicks related to changes in metabolic or endocrinal status? | this study examines the possibility that metabolic or endocrinal factors initiate fledging in the king penguin, a semi-altricial seabird species breeding a single chick on the ground. chick fledging (departure to sea) occurred 5d after completion of the molt. it was preceded by a 16d fasting period and by a 7-fold increase in locomotor activity. from the measurement of the plasma concentration of metabolites and of glucagon and insulin, pre-fledging king penguin chicks were found to adapt to fas ... | 2008 | 18155218 |
| localised malignant pleural mesothelioma: a separate clinical entity requiring aggressive local surgery. | localised malignant pleural mesotheliomas are very rare and although there are sporadic reports in the literature showing that they have a different biological behaviour compared to diffuse mpm there is no major series published demonstrating results of surgical treatment. we present our experience in treating these tumours. | 2008 | 18155556 |
| have surgical outcomes of pathologic t4 esophageal squamous cell carcinoma really improved? analysis of 268 cases during 45 years of experience. | because invasion to an adjacent organ (t4) indicates highly advanced disease, and most surgeons avoid esophagectomy, the prognostic impact of clinicopathologic factors for survival of these patients after esophagectomy has rarely been analyzed. | 2008 | 18155568 |
| treatment of patients with unresectable squamous head and neck cancer with induction chemotherapy followed by hyperfractionated radiotherapy. | the contribution of induction chemotherapy (ct) followed by hyperfractionated radiotherapy (hfrt) in unresectable squamous head and neck cancer has been evaluated in a single institution as an assistencial protocol. | 2008 | 18155633 |
| competitive immunoassays for simultaneous detection of metabolites and proteins using micromosaic patterning. | new high-throughput immunoassay methods for rapid point-of-care diagnostic applications represent an unmet need and current focus of numerous innovative methods. we report a new micromosaic competitive immunoassay developed for the analysis of the thyroid hormone thyroxine (t4), inflammation biomarker c-reactive protein (crp), and the oxidative damage marker 3-nitrotyrosine (bsa-3nt) on a silicon nitride substrate. to demonstrate the versatility of the method, both direct and indirect format com ... | 2008 | 18092765 |
| the duisburg birth cohort study: influence of the prenatal exposure to pcdd/fs and dioxin-like pcbs on thyroid hormone status in newborns and neurodevelopment of infants until the age of 24 months. | prenatal exposure to polychlorinated biphenyls (pcbs) and polychlorinated dibenzo-p-dioxins and dibenzofurans (pcdd/fs) can affect neurobehavioral development of infants and children. this effect may be mediated through disruption of thyroid hormone homeostasis. however, epidemiological studies reveal no consistent influence of pcdd/fs and pcbs on thyroid status and neurodevelopment at environmental background levels. the effects may resolve with time of further decreasing exposure to these comp ... | 2008 | 18093869 |
| accuracy of preoperative t-staging of gallbladder carcinoma using mdct. | the objective of our study was to evaluate the performance of mdct in the preoperative t-staging of gallbladder cancer and to determine whether adding multiplanar reconstruction (mpr) images to axial images can improve the accuracy of mdct for the t-staging of gallbladder cancer. | 2008 | 18094296 |
| prognostic impact of perineural invasion following pancreatoduodenectomy with lymphadenectomy for ampullary carcinoma. | the aim of this study was to identify prognostic factors in patients undergoing pancreatoduodenectomy with lymphadenectomy for ampullary carcinoma. the records of 46 consecutive patients with ampullary carcinoma who underwent pancreatoduodenectomy from 1988 through 2006 were retrospectively reviewed. a 98% rate of potentially curative (r0) resection was achieved. there was no 30-day mortality. overall 5-year survival rate was 64%. univariate analysis revealed that t3 and t4 tumor (i.e., pancreat ... | 2008 | 18095164 |
| structural determinants of nitroxide motion in spin-labeled proteins: solvent-exposed sites in helix b of t4 lysozyme. | site-directed spin labeling provides a means for exploring structure and dynamics in proteins. to interpret the complex epr spectra that often arise, it is necessary to characterize the rotamers of the spin-labeled side chain and the interactions they make with the local environment in proteins of known structure. for this purpose, crystal structures have been determined for t4 lysozyme bearing a nitroxide side chain (r1) at the solvent-exposed helical sites 41 and 44 in the b helix. these sites ... | 2008 | 18096642 |
| tumor pathology and long-term survival in emergency colorectal cancer. | patients who have an emergency operation for colorectal cancer have poorer long-term survival outcomes compared with elective patients. this study was designed to define the role of tumor pathology as a basis for the differences in survival outcomes. | 2008 | 18097722 |
| cohabitation status and onset of disability among older danes: is social participation a possible mediator? | to investigate the effect of cohabitation status in older men and women on (a) onset of disability at 3- and 4.5-year follow-up and (b) changes in functional ability between 3- and 4.5-year follow-up, and to analyze whether this effect was mediated by social participation. | 2008 | 18089766 |
| maternal hyperthyroidism in rats impairs stress coping of adult offspring. | given the evidence that maternal hyperthyroidism (mh) compromises expression of neuronal cytoskeletal proteins in the late fetal brain by accelerated neuronal differentiation, we investigated possible consequences of mh for the emotional and cognitive functions of adult offspring during acute and subchronic stress coping. experimental groups consisted of male rat offspring from mothers implanted with osmotic minipumps infusing either thyroxine (mh) or vehicle (ctrl) during pregnancy. body weight ... | 2008 | 18074386 |
| topical treatment with ogg1 enzyme affects uvb-induced skin carcinogenesis. | nonmelanoma skin cancer resulting from uvb exposure is a large and growing problem in the united states. production of reactive oxygen species (ros) during the uvb-induced inflammatory response results in the formation of oxidative dna adducts such as 8-hydroxy-2-deoxyguanine (8-oxo-dg), which have been shown to contribute to the development of this cancer. the 8-oxoguanine dna glycosylase (ogg1) enzyme repairs 8-oxo-dg adducts, suggesting that enhancing its activity in the skin might increase 8 ... | 2008 | 18086242 |
| use of stable nitrogen isotope fractionation to estimate denitrification in small constructed wetlands treating agricultural runoff. | constructed wetlands (cws) in the agricultural landscape reduce non-point source pollution through removal of nutrients and particles. the objective of this study was to evaluate if measurements of natural abundance of (15)no(3)(-) can be used to determine the fate of no(3)(-) in different types of small cws treating agricultural runoff. nitrogen removal was studied in wetland trenches filled with different filter materials (t1--sand and gravel; t3--mixture of peat, shell sand and light-weight a ... | 2008 | 18086487 |
| macrophage migration inhibitory factor in pediatric patients undergoing surgery for congenital heart repair. | macrophage migration inhibitory factor (mif), a proinflammatory mediator, has been shown to be elevated following heart surgery in adults and may be associated with several postoperative complications, including cardiac and pulmonary dysfunction. in this study, we aimed to measure perioperative plasma mif, interleukin (il)-8, and free t4 in 20 children age <4 years undergoing surgical repair of congenital heart lesions with left ventricular volume overload, and to determine whether the response ... | 2008 | 18079996 |
| aging and drinking problems among mature adults: the moderating effects of positive alcohol expectancies and workforce disengagement. | this article examines the relationship between aging and drinking problems among mature workers and the moderating effects of positive alcohol expectancies (paes) and workforce disengagement. | 2008 | 18080075 |
| brown adipose tissue sympathetic nerve activity is potentiated by activation of 5-hydroxytryptamine (5-ht)1a/5-ht7 receptors in the rat spinal cord. | in urethane-chloralose anesthetized, neuromuscularly blocked, ventilated rats, microinjection of nmda (12 pmol) into the right fourth thoracic segment (t4) spinal intermediolateral nucleus (iml) immediately increased ipsilateral brown adipose tissue (bat) sympathetic nerve activity (sna; peak +492% of control), expired co2 (+0.1%) heart rate (+48 beats min(-1)) and arterial pressure (+8 mmhg). the increase in bat sna evoked by t4 iml microinjection of nmda was potentiated when it was administere ... | 2008 | 18082230 |
| lycopus europaeus (gypsywort): effects on the thyroidal parameters and symptoms associated with thyroid function. | the aim of the prospective two-armed open study was to examine the effect of lycopi europaei herba on thyroid function and on associated symptoms during a 3-month follow-up phase. the study population consisted of patients with a basal tsh<1.0 mu/l and hyperthyroidism-associated symptoms. for the first time, the t3/t4 excretion in 24h urine was measured as a primary objective parameter. as secondary parameters, further hormones, the general condition and the symptoms associated with hyperthyroid ... | 2008 | 18083505 |
| one-base excess adaptor ligation method for walking uncloned genomic dna. | this report describes a novel and efficient method for walking the sequence of a genomic deoxyribonucleic acid (dna) from a known region to an unknown region based on an oligodeoxynucleotide (oligo) cassette-mediated polymerase chain reaction technique. in this method, genomic dna is digested by a restriction enzyme that generates a sticky 5'-end, followed by ligation of a one-base excess oligo-adaptor using t4 dna ligase. the adaptor consists of two complementary oligos that form the same stick ... | 2008 | 18071644 |
| type 2 deiodinase polymorphism (threonine 92 alanine) predicts l-thyroxine dose to achieve target thyrotropin levels in thyroidectomized patients. | type 2 deiodinase (d2) converts t4 in t3 in several human tissues, including hypothalamus and pituitary, and, therefore, plays a pivotal role in the negative feedback regulation of tsh secretion. a common variant of the gene, threonine (thr) 92 alanine (ala), has been identified and associated with decreased d2 enzymatic activity. | 2008 | 18073314 |
| long-term results after dissection of positive thoracic lymph nodes in patients with esophageal squamous cell carcinoma. | although thoracic lymph node metastasis in patients with thoracic esophageal squamous cell carcinoma (scc) has been reported to be a negative risk factor for long-term survival, only a few studies have evaluated the clinicopathologic difference between the impact of metastasis to the paraesophageal lymph nodes and to the nonparaesophageal lymph nodes. the purpose of this study was to evaluate surgical outcome after the clearance of metastatic thoracic lymph nodes. | 2008 | 18066616 |
| combined spinal and epidural anaesthesia with chloroprocaine for hysterectomy. | 1. the aim of the present study was to determine the clinical efficacy and safety of chloroprocaine (cp) for gynaecological surgery. 2. one hundred and twenty gynaecological patients scheduled for hysterectomy were divided randomly into four groups: group a (n = 30), 2.5% cp 1.0 ml; group b (n = 30), 2.5% cp 1.2 ml; group c (n = 30), 2.5% cp 1.4 ml; and group d (n = 30), 2.5% cp 1.6 ml. the dose of cp used in each group was mixed with 1 ml vehicle containing 5% glucose and 1.5% ephedrine. spinal ... | 2008 | 18047629 |
| structure and orientation of t4 lysozyme bound to the small heat shock protein alpha-crystallin. | we have determined the structural changes that accompany the formation of a stable complex between a destabilized mutant of t4 lysozyme (t4l) and the small heat shock protein alpha-crystallin. using pairs of fluorescence or spin label probes to fingerprint the t4l tertiary fold, we demonstrate that binding disrupts tertiary packing in the two domains as well as across the active-site cleft. furthermore, increased distances between i and i+4 residues of helices support a model in which the bound ... | 2008 | 18062989 |
| thyroid hormone status and pituitary function in adult rats given oral doses of perfluorooctanesulfonate (pfos). | perfluorooctanesulfonate (pfos) is widely distributed and persistent in humans and wildlife. prior toxicological studies have reported decreased total and free thyroid hormones in serum without a major compensatory rise in thyrotropin (tsh) or altered thyroid gland histology. although these animals (rats, mice and monkeys) might have maintained an euthyroid state, the basis for hypothyroxinemia remained unclear. we undertook this study to investigate the causes for the pfos-induced reduction of ... | 2008 | 18063289 |
| is thyroid autoimmunity a risk factor for developing primary myelodysplastic syndrome? | thyroid disease has been associated with leukemia and lymphoma. no previous study using clinical and laboratory data has explored whether thyroid disease and especially autoimmune thyroid disease (atd) is associated with myelodysplastic syndrome (mds) risk. in this case-control study, we investigated the association of atd with mds. | 2008 | 18064534 |
| nongenomic regulation of glutamatergic neurotransmission in hippocampus by thyroid hormones. | thyroid hormones (ths) are well known for their genomic effects but recently attention has focused also on their nongenomic actions as rapid modulators of membrane receptors. here we show that thyroxine (t4) and 3,3',5'-l-triiodothyronine (t3) rapidly decrease n-methyl-d-aspartate (nmda)-evoked currents in rat hippocampal cultures with potency in the micromolar range. the effect is not mediated by glutamate or glycine binding sites as an increase in agonist or glycine concentration does not alte ... | 2008 | 18065155 |
| eeg of chronic marijuana users during abstinence: relationship to years of marijuana use, cerebral blood flow and thyroid function. | marijuana abuse is associated with neurological changes including increases in frontal eeg alpha during abstinence. research is needed to assess to what extent these eeg patterns are indicative of cerebral perfusion deficits. | 2008 | 18065267 |
| a simple ligation-based method to increase the information density in sequencing reactions used to deconvolute nucleic acid selections. | herein, a method is described to increase the information density of sequencing experiments used to deconvolute nucleic acid selections. the method is facile and should be applicable to any selection experiment. a critical feature of this method is the use of biotinylated primers to amplify and encode a bamhi restriction site on both ends of a pcr product. after amplification, the pcr reaction is captured onto streptavidin resin, washed, and digested directly on the resin. resin-based digestion ... | 2008 | 18065718 |
| scoliosis correction with pedicle screws in duchenne muscular dystrophy. | this report describes the spinal fixation with pedicle-screw-alone constructs for the posterior correction of scoliosis in patients suffering from duchenne muscular dystrophy (dmd). twenty consecutive patients were prospectively followed up for an average of 5.2 years (min 2 years). all patients were instrumented from t3/t4 to the pelvis. pelvic fixation was done with iliac screws similar to galveston technique. the combination of l5 pedicle screws and iliac screws provided a stable caudal found ... | 2008 | 18057966 |
| concurrent chemoradiotherapy or endoscopic stenting for advanced squamous cell carcinoma of esophagus: a case-control study. | we evaluated the role of chemoradiotherapy (crt) for patients with inoperable squamous esophageal cancer. | 2008 | 18057993 |
| survival benefits of pancreatoduodenectomy for gastric cancer: relationship to the number of lymph node metastases. | pancreatoduodenectomy (pd) for advanced gastric cancer is rarely performed because of the high frequency of associated morbidity and mortality. the aim of this study was to determine the limited indication of pd for advanced gastric cancer. | 2008 | 18060424 |
| prospective investigation into the influence of various stressors on skin impedance. | the control mechanisms during general anesthesia include circulation parameters and vegetative reactions. a possible way to quantify vegetative reactions is to measure the impedance of the skin. an activation of the eccrine sweat glands via sympathetic sudomotor fibers induces a secretion of sweat, which generates a drop in skin impedance. the aim of the present study was to investigate the influence which different stressors and measurement electrodes have upon skin impedance. | 2008 | 18049905 |
| molecular characterization of l-413c, a p2-related plague diagnostic bacteriophage. | our analysis of the plague diagnostic phage l-413c genome sequence and structure reveals that l-413c is highly similar and collinear with enterobacteriophage p2, though important differences were found. of special interest was the mosaic nature of the tail fiber protein h in l-413c, given the differentiating specificity of this phage for yersinia pestis vs. yersinia pseudotuberculosis. while the n-terminal 207 and c-terminal 137 amino acids of l-413c display significant homology with the p2 h pr ... | 2008 | 18045639 |
| design and biophysical characterization of novel polycationic epsilon-peptides for dna compaction and delivery. | design and solid-phase synthesis of novel and chemically defined linear and branched -oligo( l-lysines) (denoted -k n, where n is the number of lysine residues) and their alpha-substituted homologues (epsilon-(r)k10, epsilon-(y)k10, epsilon-(l)k10, epsilon-(yr)k10, and epsilon-(lyr)k10) for dna compaction and delivery are reported. the ability to condense viral (t2 and t4) and plasmid dna as well as the size of -peptide dna complexes under different conditions was investigated with static and dy ... | 2008 | 18047291 |
| prediction of hypothyroidism after hemithyroidectomy: a biochemical and pathological analysis. | the possibility of postsurgical hypothyroidism after hemithyroidectomy is no longer a new subject. although many previous studies have mentioned posthemithyroidectomy hypothyroidism, the incidence and contributing factors for hypothyroidism remain uncertain. we intended to evaluate the incidence and the time of development of hypothyroidism after hemithyroidectomy and to analyze the relationship of posthemithyroidectomy hypothyroidism with preoperative biochemical parameters and postoperative hi ... | 2008 | 17978827 |
| survival prognostic factors for lateral bucco-pharyngeal junction squamous cell carcinoma. | squamous cell carcinomas (scc) localized at the lateral buccopharyngeal junction are frequent occurrences in our experience. this anatomical site gives the tumor ample space to spread in different directions, making tumor management all the more difficult. we focused our study on this localization to underline their specificities and evaluate our practices. in the department of head and neck oncology at the centre oscar lambret, 57 patients with lateral bucco-pharyngeal junction scc were treated ... | 2008 | 17978830 |
| enantiorecognition of triiodothyronine and thyroxine enantiomers using different chiral selectors by hplc and micro-hplc. | this paper deals with the chiral separation of triiodothyronine (t3) and thyroxine (t4) by hplc and micro-hplc. the separation of t3 and t4 is of great pharmaceutical and clinical interest, since the enantiomers exhibit different pharmacological activities. the hplc measurements were performed on a chiral stationary ligand-exchange phase using l-4-hydroxyproline bonded via 3-glycidoxypropyltrimethoxysilane to silica gel as a selector. also a chiral teicoplanin (chirobiotic) phase was used. in mi ... | 2008 | 17980436 |
| role of adjuvant chemoradiation therapy in adenocarcinomas of the ampulla of vater. | the role of adjuvant chemoradiation therapy (crt) in the treatment of ampullary cancers remains undefined. we retrospectively compared treatment outcomes in patients treated with pancreaticoduodenectomy alone versus those who received additional adjuvant crt. | 2008 | 17980502 |
| heritability of serum tsh, free t4 and free t3 concentrations: a study of a large uk twin cohort. | thyroid hormone action influences many metabolic and synthetic processes, but the degree of regulation attributed to genes and environmental factors affecting normal variation remains controversial. | 2008 | 17970774 |
| sebaceous carcinoma of the eyelids: a review of 21 cases. | sebaceous carcinoma is a malignant neoplasm that arises from the sebaceous glands and occurs most often in the eyelids. a tumour diameter exceeding 10mm indicates a grave prognosis. however, thus far, no study has used the t classification of the tumour, node, metastasis (tnm) staging system to determine the prognosis. in this article, we studied the management and outcomes of sebaceous carcinoma using the t classification. | 2008 | 17974515 |
| a finite element framework for computation of protein normal modes and mechanical response. | a computational framework based on the finite element method is presented to calculate the normal modes and mechanical response of proteins and their supramolecular assemblies. motivated by elastic network models, proteins are treated as continuum elastic solids with molecular volume defined by their solvent-excluded surface. the discretized finite element representation is obtained using a surface simplification algorithm that facilitates the generation of models of arbitrary prescribed spatial ... | 2008 | 17975833 |
| use of postmastectomy radiotherapy in older women. | clinical trials and guidelines published between 1997 and 2001 concluded that postmastectomy radiotherapy (pmrt) improves overall survival for women with high-risk breast cancer. however, the effect of these findings on current practice is not known. using the surveillance, epidemiology, and end results-medicare cohort, we sought to characterize the adoption of pmrt from 1992 to 2002 and identify risk factors for pmrt omission among high-risk older patients. | 2008 | 17996393 |
| bacteriophage preparation inhibition of reactive oxygen species generation by endotoxin-stimulated polymorphonuclear leukocytes. | it has been known that administration of antibiotics may lead to excessive release of bacterial endotoxins and complicate clinical course of patients with gram-negative infections. this concern may also apply to phages. endotoxin may in turn activate neutrophils to produce reactive oxygen species (ros) that are believed to play an important role in the pathogenesis of multiple organ dysfunction in the course of sepsis. we showed that a purified t4 phage preparation with low-endotoxin content cou ... | 2008 | 17996972 |
| is a positive bladder neck margin truly a t4 lesion in the prostate specific antigen era? results from the search database. | positive bladder neck margins after radical prostatectomy are currently designated as pt4 lesions. however, to our knowledge the prognostic significance of a positive bladder neck margin in the prostate specific antigen era is unknown. we examined the association between positive bladder neck margins and prostate specific antigen recurrence relative to other pathological findings. | 2008 | 17997433 |
| multifocal t4 non-small cell lung cancer: a subset with improved prognosis. | t4-disease for non-small cell lung cancer (nsclc) includes different conditions: mediastinal invasion, neoplastic pleural cytology, and multifocal disease in the same lobe; regarding the last category, no strict criteria allow to differentiate satellite nodules from synchronous multiple primary tumours. | 2008 | 17983760 |
| expression of er, pgr, her1, her2, and response: a study of preoperative chemotherapy. | to identify the role of estrogen (er), progesterone (pgr), epidermal growth factor 1 (her1), and her2 receptors in predicting response to preoperative chemotherapy. | 2008 | 17986623 |
| the thyroid gland and thyroid hormones in senegalese sole (solea senegalensis) during early development and metamorphosis. | we here describe the ontogeny and morphology of the thyroid gland in senegalese sole (solea senegalensis), and correlate these with whole body concentrations of thyroid hormones during early development and metamorphosis. under our rearing conditions at 19.5 degrees c, most larvae entered metamorphosis in stage 1 at 15 days post-hatching (dph), and completed metamorphosis in stage 4 at 25dph. the onset of metamorphosis coincided with surges in whole body t4 and t3 concentrations. crossmon's tric ... | 2008 | 17977536 |
| multiple short-segment laminoplasties in children: a novel technique to avoid postoperative spinal deformity. | spinal deformity is a recognized important complication after laminectomies, especially in children. even with laminoplasties, spinal deformity is a concern, especially when laminoplasties involve multiple levels. the author reports a novel technique to avoid postoperative spinal deformity using multiple short-segment replacement laminoplasties to access pathology over a long segment of the intraspinal space. | 2008 | 18043924 |
| complete clinical response after preoperative chemoradiation in rectal cancer: is a "wait and see" policy justified? | a proportion of patients, who receive preoperative chemoradiation for locally advanced (t3, t4, nx) rectal cancer achieve a complete clinical response and a pathologic complete response in the region of 15 to 30 percent. support is growing in the united kingdom for the concept of "waiting to see" and not proceeding to radical surgery when a complete clinical response is observed. the purpose of this review was to use a literature search to assess how often complete clinical response is achieved ... | 2008 | 18043968 |
| restriction endonuclease inhibitor ipi* of bacteriophage t4: a novel structure for a dedicated target. | phage t4 protects its dna from the two-gene-encoded gmrs/gmrd (glucose-modified hydroxymethylcytosine restriction endonuclease) ct of pathogenic escherichia coli, ct596, by injecting several hundred copies of the 76-amino-acid-residue nuclease inhibitor, ipi*, into the infected host. here, the three-dimensional solution structure of mature ipi* is reported as determined by nuclear magnetic resonance techniques using 1290 experimental nuclear overhauser effect and dipolar coupling constraints ( a ... | 2008 | 18037438 |
| effects of light to moderate alcohol consumption on thyroid volume and thyroid function. | to examine a possible relationship between alcohol consumption and thyroid volume and function. | 2008 | 18031329 |
| management and outcome of patients with mucoepidermoid carcinoma of major salivary gland origin: a single institution's 30-year experience. | mucoepidermoid carcinoma (mec) is one of the most frequent epithelial malignancies of the salivary glands. prediction of clinical outcome of mec is challenging. | 2008 | 18030166 |
| survival and health outcomes after cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for disseminated peritoneal cancer of appendiceal origin. | cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis of appendiceal origin can alleviate symptoms and prolong survival. this aggressive therapy may impair patient quality of life (qol). the purpose of this study was to monitor health outcomes before and after treatment. | 2008 | 18030535 |
| bladder-sparing, combined-modality approach for muscle-invasive bladder cancer: a multi-institutional, long-term experience. | the authors evaluated their long-term experience with combined-modality, conservative treatment in patients with muscle-invasive bladder cancer. | 2008 | 18008364 |
| post-traumatic syringomyelia producing paraplegia in an infant. | post-traumatic syringomyelia is described in adults after spinal trauma but extremely rarely seen in children, especially in the first year of life. | 2008 | 18026959 |
| optimal endotracheal tube tip position in extremely premature infants. | although right main bronchus intubation is associated with adverse consequences, the optimal endotracheal tube (ett) tip position above the carina in neonates is not known. the aim of this study was to determine the association between ett tip position and adverse pulmonary effects as assessed by chest radiographs (cxrs). lung aeration was examined after masking ett positions in the first two cxrs taken after birth in 74 consecutive ventilated premature infants <or= 28 weeks. all the cxrs of the ... | 2008 | 18027311 |
| outcomes and prognostic variables in adenoid cystic carcinoma of the head and neck: a recent experience. | to analyze the recent experience of patients with adenoid cystic carcinoma treated with radiation therapy at memorial sloan-kettering cancer center. | 2008 | 18029108 |
| thyroxine therapy in euthyroid patients does not affect body composition or muscular function. | the main objective of the study was to evaluate the effects of small increments in thyroxine (t4) levels following levothyroxine (l-t4) administration on the body composition of women patients. the secondary objective was to assess the effect of the therapy on energy expenditure and muscular function. | 2008 | 17988199 |
| characterization of thyroid hormones and thyroid hormone receptors during the early development of pacific bluefin tuna (thunnus orientalis). | we studied the profiles of 3,5,3'-l-triiodothyronine (t3), thyroxine (t4), and thyroid hormone receptors (trs) in pacific bluefin tuna (thunnus orientalis) during embryonic and post-embryonic development. both t3 and t4 were detected in embryos just before hatching, and it was found that the levels of both were increased in postflexion fish. the thyroid follicles were increased in both size and number in postflexion fish compared with preflexion fish. a trbeta cdna clone was generated by race. t ... | 2008 | 17988667 |
| modulation of cardiac ischemia-sensitive afferent neuron signaling by preemptive c2 spinal cord stimulation: effect on substance p release from rat spinal cord. | the upper cervical spinal region functions as an intraspinal controller of thoracic spinal reflexes and contributes to neuronal regulation of the ischemic myocardium. our objective was to determine whether stimulation of the c2 cervical spinal cord (scs) of rats modified the input signal at the thoracic spinal cord when cardiac ischemia-sensitive (sympathetic) afferents were activated by transient occlusion of the left anterior descending coronary artery (coao). changes in c-fos expression were ... | 2008 | 17989135 |
| tcrgamma-chain gene rearrangement by pcr-based genescan: diagnostic accuracy improvement and clonal heterogeneity analysis in multiple cutaneous t-cell lymphoma samples. | cutaneous t-cell lymphomas are a heterogeneous group of lymphomas where the tumor population emerges within a multiple subclone pattern ("clonal heterogeneity"). pcr analysis has been shown to be useful in the diagnosis of mycosis fungoides (mf) and sézary syndrome (ss). focusing the attention on clonal heterogeneity, the efficacy of the multiplex/heteroduplex (hd) pcr and the genescan (gs) capillary electrophoresis analysis was compared in the early diagnosis of mf/ss, using a multiple sample a ... | 2008 | 17989737 |
| improvement of dna adenylation using t4 dna ligase with a template strand and a strategically mismatched acceptor strand. | dna with a 5'-adenylpyrophosphoryl cap (5'-adenylated dna; appdna) is an activated form of dna that is the biochemical intermediate of the reactions catalyzed by dna ligase, rna ligase, polynucleotide kinase, and other nucleic acid modifying enzymes. 5'-adenylated dna is also useful for in vitro selection experiments. efficient preparation of 5'-adenylated dna is therefore desirable for several biochemical applications. here we have developed a dna adenylation procedure that uses t4 dna ligase a ... | 2008 | 18022669 |
| endocrine stress response and inflammatory activation during cabg surgery. a randomized trial comparing remifentanil infusion to intermittent fentanyl. | our aim was to compare a continuous infusion of remifentanil with intermittent boluses of fentanyl as regards the perioperative hormonal stress response and inflammatory activation in coronary artery bypass graft patients under sevoflurane-based anaesthesia. | 2008 | 18005471 |
| phase ii study of preoperative helical tomotherapy for rectal cancer. | to explore the efficacy and toxicity profile of helical tomotherapy in the preoperative treatment of patients with rectal cancer. | 2008 | 17904302 |
| extraosseous epidural multiple myeloma presenting with thoracic spine compression. | multiple myeloma is a hematopoetic disorder and multicentric disease, with the most common localisation being the spine. a 47-year-old male presented with progressive paraplegia, superficial and deep sensory disturbance below the level of t4. spinal magnetic resonance image showed an epidural mass compressing the spinal cord at the level of t4-t6 with intact bone structure. the patient underwent surgical t4-t6 posterior spinal decompression. microscopic examination and immunohistochemical studie ... | 2008 | 17905632 |
| stress fracture of the tibia following a vascularised free fibular flap. | a 49-year-old female presented with a t4 n2 mo moderately differentiated squamous cell carcinoma of the right cheek mucosa and involving the mandible. patient treatment included resection of the tumour with partial mandibulectomy, maxillectomy and a free osteocutaneous fibular flap to reconstruct the bony mandibular and soft tissue intraoral defects. six weeks postoperatively the patient developed a stress fracture of the right tibia, a complication which has not been reported in the literature ... | 2008 | 17901006 |
| reference range of thyroid hormones in normal indian school-age children. | there is an ongoing debate on narrowing the tsh reference range in adults. in view of the scarce data on normal values of thyroid function tests in children from india, we planned to establish a reference range for thyroid hormones in school-age children. | 2008 | 17897329 |
| the influence of epidural volume extension on spinal block with hyperbaric or plain bupivacaine for caesarean delivery. | epidural volume extension via a combined spinal-epidural is the enhancement of a small-dose intrathecal block by an epidural injection of physiological saline solution. we evaluated the effect of epidural volume extension on the combined spinal-epidural technique of providing spinal anaesthesia for caesarean section with hyperbaric or plain 0.5% bupivacaine. | 2008 | 17888192 |
| thyroid hormones down-regulate thyrotropin beta subunit and thyroglobulin during metamorphosis in the flatfish senegalese sole (solea senegalensis kaup). | thyroid hormones (th) play a critical role in flatfish metamorphosis. their levels are regulated by the pituitary-thyroid axis. the expression profile of thyroid stimulating hormone (tsh) beta subunit and thyroglobulin (tg) was investigated using a real-time pcr approach. both genes exhibited different expression patterns during larval development in senegalese sole. tsh beta mrnas reduced progressively at the commencement of metamorphosis. on the contrary, tg transcripts increased sharply at th ... | 2008 | 17888916 |
| phase i-ii trial of cetuximab, capecitabine, oxaliplatin, and radiotherapy as preoperative treatment in rectal cancer. | to evaluate the safety and activity of preoperative radiotherapy (rt) with concurrent cetuximab, capecitabine, and oxaliplatin in rectal cancer patients. | 2008 | 17881150 |
| full correlation analysis of conformational protein dynamics. | correlated motions in biomolecules are often essential for their function, for example, allosteric signal transduction or mechanical/thermodynamic energy transport. principal component analysis (pca) is a widely used method to extract functionally relevant collective motions from a molecular dynamics (md) trajectory. being based on the covariance matrix, however, pca detects only linear correlations. here we present a new method, full correlation analysis (fca), which is based on mutual informat ... | 2008 | 17876828 |
| supracricoid laryngectomy with cricohyoidoepiglotto-pexy or cricohyoido-pexy: experience on 32 patients. | supracricoid laryngectomy (scl) with cricohyoidoepiglotto-pexy (chep) or cricohyoido-pexy (chp) is an organ preservation surgery indicated for early and selected advanced laryngeal cancers. to verify the clinical usefulness of supracricoid laryngectomy versus total laryngectomy, a retrospective review was conducted. | 2008 | 17869042 |
| primary tumor volume calculation as a predictive factor of prognosis in nasopharyngeal carcinoma. | primary tumor volume (ptv) has a close relationship with survival rates of patients with nasopharyngeal carcinoma (npc) who were treated with concurrent chemoradiotherapy (ccrt) or radiotherapy. besides the current ajcc staging system, measurement of ptv may be needed to predict prognosis of npc and adjust treatment strategy. | 2008 | 17851945 |
| does a highly sensitive thyroglobulin (tg) assay change the clinical management of low-risk patients with thyroid cancer with tg on t4 < 1 ng/ml determined by traditional assays? | to evaluate a highly sensitive thyroglobulin (tg) assay [functional sensitivity (fs): 0.1 ng/ml] (tg-icma) in low-risk patients with known tg on t4 < or = 1 ng/ml measured by a traditional assay (fs: 1 ng/ml) (tg-irma). | 2008 | 17850379 |
| vertebral body shape variation in the thoracic and lumbar spine: characterization of its asymmetry and wedging. | this study was designed to characterize the vertebral body (vb) shape, focusing on vertebral wedging, along the thoracic and lumbar spine, and to look for shape variations with relation to gender, age, and ethnicity. all thoracic and lumbar (t1-l5) dissected vertebrae of 240 individuals were measured and analyzed by age, gender, and ethnicity. a 3d digitizer was used to measure all vb lengths, heights, and widths, and their ratios were calculated. this study showed that the vb size was independe ... | 2008 | 17729333 |
| effects of serum tsh and ft4 levels and the tshr-asp727glu polymorphism on bone: the rotterdam study. | tsh and thyroid hormone may have independent effects on bone. in this study we investigated the association of tsh and free t4 (ft4) with different bone parameters in human subjects. tsh and ft4 are known to be associated with body mass index (bmi) and a higher bmi gives a higher bone mineral density (bmd). thus, we aimed to determine whether the effects of tsh and ft4 on bone are mediated by bmi. as tsh exerts its biological effect through the tsh receptor (tshr), the tshr gene might be a candi ... | 2008 | 17803697 |
| pegfilgrastim +/- ciprofloxacin for primary prophylaxis with tac (docetaxel/doxorubicin/cyclophosphamide) chemotherapy for breast cancer. results from the gepartrio study. | tac (docetaxel/doxorubicin/cyclophosphamide) is associated with high incidences of grade 4 neutropenia and febrile neutropenia (fn). this analysis compared the efficacies of four regimens for primary prophylaxis of fn and related toxic effects in breast cancer patients receiving neoadjuvant tac. | 2008 | 17846019 |
| effect of the number of concentrate feeding places per pen on performance, behavior, and welfare indicators of friesian calves during the first month after arrival at the feedlot. | seventy-two friesian calves (bw = 102.0 +/- 1.8 kg) were bought from a commercial calf farm and distributed to a factorial arrangement of treatments in a complete block design with 3 treatments and 3 blocks of similar fasted bw to study the effect of increasing the number of feeding places per pen on performance, behavior, and welfare indicators during the 4 wk after arrival. treatments consisted of 1 (t1), 2 (t2), or 4 (t4) concentrate feeding places/pen (8 calves/pen). concentrate and straw we ... | 2008 | 17940151 |
| uterotrophic assay, hershberger assay, and subacute oral toxicity study of 4,4'-butylidenebis(2-tert-butyl-5-methylphenol) and 3-(dibutylamino)phenol, based on the oecd draft protocols. | we performed a uterotrophic assay, the hershberger assay, and a 28-day repeated-dose toxicity study [enhanced organization for economic co-operation and development (oecd) test guideline no. 407] of 4,4'-butylidenebis(2-tert-butyl-5-methylphenol) and 3-(dibutylamino)phenol, based on the oecd draft protocols. in the uterotrophic assay of 4,4'-butylidenebis(2-tert-butyl-5-methylphenol), female sd rats were subcutaneously injected with the chemical at doses of 0, 100, 300, and 1,000 mg/kg on each o ... | 2008 | 17924095 |
| impaired serum thyrotropin response to hypothyroidism in mice with disruption of neuromedin b receptor. | neuromedin b (nb), a neuropeptide highly concentrated in pituitary, has been proposed to be an inhibitor of thyrotropin (tsh) secretion. previous study showed that mice with disruption of neuromedin b receptor (nbr-ko) have higher tsh release in response to thyrotropin-releasing hormone (trh), although tsh seems to have decreased bioactivity. here we examined in nbr-ko mice the response of tsh to thyroid hormone (th) deprivation, obtained by methimazole treatment, or excess, obtained by acute an ... | 2008 | 17931717 |
| neoadjuvant and adjuvant therapy in patients with oral squamous cell carcinoma long-term survival in a prospective, non-randomized study. | recently new concepts for the treatment of oral squamous cell carcinomas (scc) have been developed, which include preoperative simultaneous neoadjuvant radiochemotherapy (rct) and one stage operation with excision of the tumour and reconstruction. when we consider long-term survival, we find substantial evidence that combined treatment based on neoadjuvant radiochemotherapy is superior to adjuvant treatment including operation and postoperative radiation. | 2008 | 17931758 |
| high serum bile acids cause hyperthyroidism and goiter. | in the duodenal content reflux model of rats, we noted an elevation of serum bile acid and swelling of the thyroid gland. this study was designed to elucidate whether bile acids (bas) also enhance thyroid function. | 2008 | 17932765 |
| water-soluble, electroactive, and photoluminescent quaterthiophene-dinucleotide conjugates. | quaterthiophene-dinucleotide conjugates 5'ta3'-t4-3'at5', 5'aa3'-t4-3'aa5', and 5'tt3'-t4-3'tt5' (ta: thymidine-adenosine, aa: adenosine-adenosine, tt: thymidine-thymidine) were synthesized and analyzed by a combination of spectroscopy and microscopy, electrical characterization, and theoretical calculations. circular dichroism (cd) experiments demonstrated a transfer of chirality from the dinucleotides to quaterthiophene at high ionic strength and in cast films. the films were photoluminescent ... | 2008 | 17933003 |
| effects of pcbs, p,p'-ddt, p,p'-dde, hcb and beta-hch on thyroid function in preschool children. | several studies have shown that some organochlorine compounds (ocs) can interfere with the thyroid system. as thyroid hormones (ths) are essential for normal brain development, it is important to study the association between ths and ocs during pregnancy and childhood. we have evaluated the relationship between thyroid function and ocs in preschool children. | 2008 | 17933884 |
| prognostic significance of altered p120 ctn expression in bladder cancer. | to identify the frequency of change in the expression and localization of p120(ctn) in bladder tumours and its association with clinical outcomes, and to investigate the potential role of p120(ctn) in the migratory and invasive behaviour of bladder carcinoma cells. | 2008 | 17922855 |
| the use of an expandable cage for corpectomy reconstruction of vertebral body tumors through a posterior extracavitary approach: a multicenter consecutive case series of prospectively followed patients. | posterior decompressions in the form of laminectomies for vertebral body tumors have poor outcomes. surgical management typically requires anterior decompression and reconstruction; however, these procedures can be associated with significant morbidity and mortality. | 2008 | 17923442 |
| interleukin-4 induces specific pp-galnac-t expression and alterations in mucin o-glycosylation in colonic epithelial cells. | mucus hypersecretion occurs as a consequence of the th2 immune response in epithelia, yet it was not previously known whether the degree of o-glycosylation was modulated under such conditions. a colonic carcinoma cell line ls174t was used to assess the effect of interleukin (il)-4 on the mrna levels of eight pp-galnac-ts. a three- to four-fold increase in pp-galnac-t1, t4, and t7 levels was observed. lysates of untreated or il-4-treated cells were examined for their ability to transfer galnac re ... | 2008 | 17916404 |
| experimental hyperthyroidism increases expression of parathyroid hormone-related peptide and type-1 parathyroid hormone receptor in rat ventricular myocardium of the langendorff ischaemia-reperfusion model. | parathyroid hormone-related peptide (pthrp) is released under ischaemic conditions and it improves contractile function of stunned myocardium. the actions of pthrp are mediated primarily by the type 1 parathyroid hormone receptor (pth.1r), while pthrp and pth.1r expression levels are increased in ventricular hypertrophy associated with experimental hyperthyroidism. since chronic administration of thyroxine (t4) improves postischaemic recovery in isolated heart models subjected to ischaemia-reper ... | 2008 | 17911357 |
| is there any prognostically different subgroup among patients with stage iiic (any tn3m0) breast carcinoma? | we investigated whether there are prognostically different subgroups among patients with stage iiic (any tn3m0) breast carcinoma. | 2008 | 17912589 |
| influence of preoperative mri on the surgical management of patients with operable breast cancer. | evaluation of the impact of preoperative magnetic resonance imaging (mri) of the breast on the clinical management of patients with operable breast cancer (bc). | 2008 | 17906928 |
| clinical benefit of palliative radiation therapy in advanced gastric cancer. | local progression of advanced gastric cancer often manifests as bleeding, dysphagia/obstruction, or pain. we evaluated the magnitude and durability of palliation with radiotherapy (rt). | 2008 | 17899453 |
| evaluation of breast sentinel lymph node coverage by standard radiation therapy fields. | biopsy of the breast sentinel lymph node (sln) is now a standard staging procedure for early-stage invasive breast cancer. the anatomic location of the breast sln and its relationship to standard radiation fields has not been described. | 2008 | 17967511 |
| quantifying dna-protein interactions by single molecule stretching. | in this chapter, we discuss a new method for quantifying dna-protein interactions. a single double-stranded dna (dsdna) molecule is stretched beyond its contour length, causing the base pairs to break while increasing the length from that of dsdna to that of ssdna. when applied in a solution containing dna binding ligands, this method of force-induced dna melting can be used to quantify the free energy of ligand binding, including the free energy of protein binding. the dependence of melting for ... | 2008 | 17964942 |
| squamous cell carcinoma of the nasal columella: a retrospective study of 66 cases from the gettec. | squamous cell carcinoma of the nasal columella (sccnc) is a rare disease. we aimed to define a strategy for the diagnosis and management of nasal columella squamous cell carcinoma. medical records of 66 patients presenting with columella squamous cell carcinoma in nine french hospitals, from 1980 to 2003, were evaluated to determine the clinical characteristics and current treatment of the disease. mean age was 69 years. the sex ratio was one female for three males. majority of the lesions were ... | 2008 | 17962969 |
| stability of the hard and soft tissue profile after mandibular advancement in sagittal split osteotomies: a longitudinal and long-term follow-up study. | the aim of the study was to conduct a long-term follow-up investigation of the stability of hard and soft tissues after bilateral sagittal split osteotomy (bsso) with rigid internal (rif) fixation to advance the mandible. sixteen consecutive patients (12 females and 4 males, mean age 21.4 years) were available for re-examination 12.7 years (t5) after surgery. the preceding follow-ups were before (t1), and 5 days (t2), 7.3 months (t3), and 13.9 months (t4) after surgery. lateral cephalograms were ... | 2008 | 17962316 |
| survival improvements for advanced stage nonbronchioloalveolar carcinoma-type nonsmall cell lung cancer cases with ipsilateral intrapulmonary nodules. | survival improvements have been demonstrated for patients with bronchioloalveolar (bac) nonsmall cell lung cancer (nsclc) with intrapulmonary satellite t4 nodules compared with other patients with stage iiib disease, and for ipsilateral intrapulmonary m1 tumors versus contralateral or distant metastasis. however, it is not known whether these differences are observed in patients with non-bac nsclc. | 2008 | 17960795 |
| naturally occurring bacteriophages lyse a large proportion of canine and feline uropathogenic escherichia coli isolates in vitro. | we investigated the feasibility of bacteriophage therapy to combat canine and feline escherichia coli urinary tract infections (utis) by testing the in vitro lytic ability of 40 naturally occurring bacteriophages on 53 uropathogenic e. coli (upec). the mean number of upec strains lysed by an individual bacteriophage was 21/53 (40%, range 17-72%). in total, 50/53 (94%) of the upec strains were killed by one or more of the bacteriophages. ten bacteriophages lysed 51% of upec strains individually a ... | 2008 | 17959211 |