Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| thyroid volume is associated with family history of thyroid disease in pregnant women with adequate iodine intake: a cross-sectional study in southern brazil. | maternal euthyroidism is important for fetal neural development. for this reason, adequate iodine nutrition during pregnancy is an important public health objective and should be periodically revised. the objective of this study was to measure urinary iodine (ui) excretion and the factors associated with thyroid volume (tv), in a group of healthy pregnant women in southern brazil, to evaluate iodine nutrition. the median ui of the 147 women was 224 microg/l (p25=164 microg/l and p75=286 microg/l ... | 2008 | 18787379 |
| reduction of blood coagulation and monocyte-platelet interaction following the use of a minimal extracorporeal circulation system (synergy) in coronary artery bypass grafting (cabg). | cardiovascular surgery with cardiopulmonary bypass (cpb) induces activation of blood coagulation and systemic inflammation involved in post-operative complications. our study evaluated the impact of the minimal extracorporeal circulation (mini-cpb) system (synergy, sorin group) on these functional aspects. twenty patients were randomly assigned to standard cpb (n = 10) or to synergy (n = 10). platelet expression of pac-1, and monocyte/granulocyte-platelet conjugates were evaluated by flow cytome ... | 2008 | 18788218 |
| early clinical results from chemoradiation with 5-fluorouracil and oxaliplatin for locally advanced rectal cancer. | preoperative chemoradiation with 5-fluorouracil (5-fu) has improved local control and resectability in patients with locally advanced rectal adenocarcinoma. the possible benefit of adding oxaliplatin is being investigated. we present background on the use of oxaliplatin as well as institutional experience assessing treatment tolerability and early outcome data. | 2008 | 18794065 |
| in vitro disc pressure profiles below scoliosis fusion constructs. | biomechanical human cadaveric study comparing straight and scoliotic spines with healthy and degenerated l4/5 discs. | 2008 | 18794754 |
| iodine in early pregnancy--is there enough? | to evaluate the iodine status of patients in early pregnancy and its dependence on level of thyroid-stimulating hormone (tsh). | 2008 | 18795082 |
| extradural giant multiloculated arachnoid cyst causing spinal cord compression in a child. | spinal extradural arachnoid cysts are rare expanding lesions in the spinal canal. enlargement may cause progressive signs and symptoms caused by spinal cord compression. they are associated with trauma, surgery, arachnoiditis, and neural tube defects. most nontraumatic spinal extradural arachnoid cysts are thought to be congenital. | 2008 | 18795482 |
| prognostic value of the detection of lymph node micrometastases in colon cancer. | a study is made of the clinical repercussions of occult metastases-micrometastases (mms+)-or isolated tumour cells (itcs+) in the lymph nodes of patients with stage iia and iib colon adenocarcinoma initially considered as corresponding to n0. | 2008 | 18796374 |
| [hgh treatment impact on adrenal and thyroid functions]. | somatotrophic status is a major determinant of both thyrotrophic and corticotrophic axis. in growth hormone deficient patients, somatotrophic replacement increases the conversion rate of the inactive form of the thyroid hormone (t4) to its active form (t3), whereas the same replacement induces the conversion of cortisol, which is hormonally active, in cortisone, its inactive form. this review details the effects of gh on these two hormonal axis, possible mechanisms and clinical implications for ... | 2008 | 18797597 |
| the correlation between the method of sympathetic ablation for palmar hyperhidrosis and the occurrence of compensatory hyperhidrosis: a review. | upper dorsal sympathectomy achieves excellent long-term results in the treatment of primary palmar hyperhidrosis. compensatory hyperhidrosis (chh) remains an unexplained sequel of this treatment, attaining in a small percentage of cases disastrous proportions. it has been claimed that lowering the level of sympathectomy (from t2 to t3 and even t4), substituting resection by other means of ablation, and limiting its extend reduce the occurrence of this sequel. this review was designed to evaluate ... | 2008 | 18797962 |
| serum antithyroid antibodies in female patients with chronic urticaria. | to determine the frequencies of serum antithyroglobulin and antimicrosomal autoantibodies in female patients with chronic urticaria, and the association between thyroid autoantibodies and chronic urticaria, if any. | 2008 | 18798586 |
| preoperative staging of mesothelioma by 18f-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography fused imaging and mediastinoscopy compared to pathological findings after extrapleural pneumonectomy. | extrapleural pneumonectomy (epp) in mpm may be confined with both morbidity and mortality and careful preoperative staging identifying resectable patients is important. staging is difficult and the accuracy of preoperative ct scan, 18f-fdg pet/ct scan (pet/ct), and mediastinoscopy is unclear. the objectives were to compare these staging techniques to each other and to surgical-pathological findings. | 2008 | 18799318 |
| sensory neuron sodium current requires nongenomic actions of thyroid hormone during development. | development of the embryonic nervous system requires thyroid hormone. however, the underlying mechanisms and targets of thyroid hormone action are not well defined. to identify embryonic roles for thyroid hormone we tested for effects on a key neuronal trait, voltage-gated sodium current (i(na)), in the zebrafish model system. we recorded from rohon-beard sensory neurons (rbs) using whole cell voltage-clamp methods. here, we provide in vivo evidence for thyroid hormone regulation of i(na). chron ... | 2008 | 18799597 |
| [endoscopic surgery in sinonasal inverted papillomas]. | to evaluate the effect and application value of endoscopic resection in sinonasal inverted papillomas. | 2008 | 18727521 |
| portal protein diversity and phage ecology. | oceanic phages are critical components of the global ecosystem, where they play a role in microbial mortality and evolution. our understanding of phage diversity is greatly limited by the lack of useful genetic diversity measures. previous studies, focusing on myophages that infect the marine cyanobacterium synechococcus, have used the coliphage t4 portal-protein-encoding homologue, gene 20 (g20), as a diversity marker. these studies revealed 10 sequence clusters, 9 oceanic and 1 freshwater, whe ... | 2008 | 18673386 |
| cancer of the external auditory canal and middle ear in denmark from 1992 to 2001. | in the context of the danish head and neck cancer group, nationwide material from 1992-2001 was analyzed to study the extent and nature of the disease, evaluate treatment, compare staging systems, and examine prognosis and survival. | 2008 | 18704969 |
| diagnostic and prognostic value of peritoneal cytology in biliary tract cancer. | evaluation of peritoneal cytology provides valuable prognostic information in abdominal cancers. the aim of this study is to assess the incidence and the prognostic value of conventional peritoneal cytology in biliary tract cancers. | 2008 | 18705279 |
| assessment of surgical treatment in elderly patients with breast cancer. | the incidence of breast cancer increases with advancing age and in clinical practice approximately 50% of new cases occur in women over the age of 65 years. although breast cancer in elderly patients presents more favorable biological characteristics than similar-stage cancer in younger women, disease control still remains uncertain and is becoming a major health problem. | 2008 | 18705397 |
| assessment of right ventricular function by pressure-volume loops in off-pump coronary artery bypass surgery. | right ventricular function plays an important role in the hemodynamic derangement during off-pump coronary artery bypass (opcab) surgery. pressure-volume loops have been shown to provide load-independent information of cardiac function. therefore, the aim of this study was to investigate the feasibility of construction of right ventricular pressure-volume loops with pressure and volume data measured by a volumetric pulmonary artery catheter (pac) and to evaluate right ventricular systolic and di ... | 2008 | 18706209 |
| does the direction of pedicle screw rotation affect the biomechanics of direct transverse plane vertebral derotation? | in vitro biomechanical investigation using human cadaveric vertebrae. | 2008 | 18708929 |
| characteristics of visual seeking and evoked potentials in the extrastriate areas of the cortex in humans. | studies in 11 young, healthy subjects addressed the characteristics of visual seeking (time taken, errors) on changes in the parameters of the target element to be sought (shape, color, and location) in an environment containing heterogeneous white distractors. evoked potentials (ep) were recorded in six cortical leads (p3, p4, t3, t4, t5, t6) and the late endogenous components of ep were studied, i.e., the n2 and p3 components (standard terminology), as these components are known to change when ... | 2008 | 18709466 |
| thyroid hormones directly alter human hair follicle functions: anagen prolongation and stimulation of both hair matrix keratinocyte proliferation and hair pigmentation. | both insufficient and excess levels of thyroid hormones (t3 and t4) can result in altered hair/skin structure and function (e.g. effluvium). however, it is still unclear whether t3 and t4 exert any direct effects on human hair follicles (hfs), and if so, how exactly human hfs respond to t3/t4 stimulation. | 2008 | 18728176 |
| c2 spinal cord stimulation induces dynorphin release from rat t4 spinal cord: potential modulation of myocardial ischemia-sensitive neurons. | during myocardial ischemia, the cranial cervical spinal cord (c1-c2) modulates the central processing of the cardiac nociceptive signal. this study was done to determine 1) whether c2 scs-induced release of an analgesic neuropeptide in the dorsal horn of the thoracic (t4) spinal cord; 2) if one of the sources of this analgesic peptide was cervical propriospinal neurons, and 3) if chemical inactivation of c2 neurons altered local t4 substance p (sp) release during concurrent c2 scs and cardiac is ... | 2008 | 18753268 |
| gross motor functional abilities in preterm-born children with cerebral palsy due to periventricular leukomalacia. | to describe the impact of periventricular leukomalacia (pvl) on gross motor function, data on 59 children (37 males, 22 females) with a gestational age (ga) of 34 weeks or less with cerebral palsy (cp) due to pvl grade i (n=20), ii (n=13), iii (n=25), and iv (n=1) were studied; (mean ga 29 wk 4d [sd 4 wk 6d]; mean birthweight 1318 g [sd 342]). two independent raters used the gross motor function classification system (gmfcs) at four time points: t1, mean corrected age (ca) 9 months 15 days (sd 2 ... | 2008 | 18754918 |
| up-regulation of alpha-catenin is associated with increased lymph node involvement in colorectal cancer. | to investigate the changing pattern of alpha-catenin expression and its relationship to clinical and pathological features of colorectal cancer (crc) patients. | 2008 | 18756598 |
| endoplasmic reticulum chaperone protein grp-78 mediates endocytosis of dentin matrix protein 1. | dentin matrix protein 1 (dmp1), a phosphorylated protein present in the mineral phase of both vertebrates and invertebrates, is a key regulatory protein during biogenic formation of mineral deposits. previously we showed that dmp1 is localized in the nuclear compartment of preosteoblasts and preodontoblasts. in the nucleus dmp1 might play an important role in the regulation of genes that control osteoblast or odontoblast differentiation. here, we show that cellular uptake of dmp1 occurs through ... | 2008 | 18757373 |
| activation of signal transducers and activators of transcription 3 and overexpression of its target gene cyclind1 in laryngeal carcinomas. | constitutive activation of signal transducers and activators of transcription (stat) 3 has been observed in many solid tumors including head and neck squamous cell carcinoma. expression and activation of stat3 in laryngeal carcinoma have not been fully understood. the study aims to investigate the expression and activation of stat3 in laryngeal carcinoma, the relationship between activated stat3 and its downstream target gene cyclind1 and the related clinicopathological factors of activated stat ... | 2008 | 18758380 |
| nongenomic actions of thyroxine modulate intermediate filament phosphorylation in cerebral cortex of rats. | the developmental effects of thyroid hormones (th) in mammalian brain are mainly mediated by nuclear receptors regulating gene expression. however, there are increasing evidences of nongenomic mechanisms of these hormones associated with kinase- and calcium-activated signaling pathways. in this context, the aim of the present work was to investigate the signaling pathways involved in the mechanism of action of th on cytoskeletal phosphorylation in cerebral cortex of 15-day-old male rats. results ... | 2008 | 18760334 |
| recent advances in the treatment of localized rectal cancer. | randomized clinical trials have recently established preoperative chemoradiotherapy as the new standard treatment for patients with localized ct3-t4 or n+ rectal cancer. although its inclusion in the modern multidisciplinary management of patients with rectal cancer makes total eradication of pelvic failure a near reality, it does not yet translate into improved survival. as a result, clinical research should be primarily directed against the micrometastatic process, focusing on integrating inno ... | 2008 | 18765152 |
| nonlinear analysis of the sleep eeg in children with pervasive developmental disorder. | autism is a severe neurodevelopmental disorder with a high rate of epilepsy and subclinical epileptiform activity. high physical connectivity on a microcolumnar level leading to epileptiform activity and low functional informational connectivity are assumed in autism. the aim of this study was to investigate nonlinear eeg brain dynamics in terms of synchronization in a group of children with autism spectrum disorders compared to a control group. we expected a lower degree of synchronization in a ... | 2008 | 18766147 |
| patterns of recurrence following liver resection for colorectal metastases: effect of primary rectal tumor site. | patients with rectal adenocarcinoma are at increased risk of locoregional recurrence compared with patients with colon cancer. this may affect the pattern of recurrence and survival rates following hepatic resection of liver metastases from rectal adenocarcinoma. | 2008 | 18711033 |
| prognostic values of serum cystatin c and beta2 microglobulin, urinary beta2 microglobulin and n-acetyl-beta-d-glucosaminidase in early acute renal failure after liver transplantation. | acute renal failure (arf) after liver transplantation is associated with high mortality and morbidity. early therapeutic or preventive intervention is hampered by the lack of early effective prognostic factors. recent studies indicated that serum levels of cystatin c and beta2-microglobulin (beta2 mg) as well as urinary beta2 mg and n-acetyl-beta-d-glucosaminidase (nag) would increase in patients with early and mild renal impairment. in this study, these factors were detected during the differen ... | 2008 | 18713542 |
| [determining the thyroid hormones t3 and t4 in the urine: an unreliable test for hypothyroidism]. | 2008 | 18714524 | |
| the effect of timing of application of positive end-expiratory pressure on oxygenation during one-lung ventilation. | many studies have confirmed that applying positive end-expiratory pressure (peep) to the dependent lung during one-lung ventilation (olv) improves oxygenation. our purpose was to investigate the best time and level of peep application. thirty patients undergoing thoracic surgery were randomised into three groups. after 20 minutes of two-lung ventilation (tlv) in the lateral position, all patients received olv for one hour during olv, 0, 5, 10 cmh2o peep were applied in order in group a, with eac ... | 2008 | 18714623 |
| [renal function in white rats after tiroxin injection preceded by blockade of ace and nitrogen oxide]. | purpose of this work was to study renal function in white rats following a single dose of exogenous tiroxin (t4) on a background of non-selective no-synthase blocker or inhibition of angiotensin-1 converting enzyme. the experiment was performed with males of outbred white rats (body mass = 140-180 g). three days prior to t4 injection, the animals drank water solution of captopril (20 mg/l) or were injected intra-gastrically with water solution of non-selective no-synthase blocker n(omega)-nla (1 ... | 2008 | 18714730 |
| folding transition of a single semiflexible polyelectrolyte chain through toroidal bundling of loop structures. | we consider how the dna coil-globule transition progresses via the formation of a toroidal ring structure. we formulate a theoretical model of this transition as a phenomenon in which an unstable single loop generated as a result of thermal fluctuation is stabilized through association with other loops along a polyelectrolyte chain. an essential property of the chain under consideration is that it follows a wormlike chain model. a toroidal bundle of loop structures is characterized by a radius a ... | 2008 | 18715107 |
| transhiatal esophagectomy in a high volume institution. | the optimal operative approach for carcinoma at the lower esophagus and esophagogastric junction remains controversial. the aim of this study was to assess a single unit experience of transhiatal esophagectomy in an era when the use of systemic oncological therapies has increased dramatically. | 2008 | 18715498 |
| tumor staging of advanced esophageal cancer: combination of double-contrast esophagography and contrast-enhanced ct. | the objective of this study was to compare the diagnostic accuracy of tumor staging in patients with advanced esophageal cancer based on contrast-enhanced ct findings alone with that based on a combination of ct and double-contrast esophagography and to evaluate the relevance of tumor stage to survival rate. | 2008 | 18716105 |
| clinical experience of the importance of daily portal imaging for head and neck imrt treatments. | the purpose of this study was to evaluate patient setup in head and neck imrt using daily portal imaging. at our institution, orthogonal digital portal images are taken daily to check patient positioning prior to head and neck imrt treatment. isocenter misalignments are corrected using a couch shift (3mm action level). therapists also compare the drrs and portal images looking at points more distant from the isocenter, particular in the supraclavicular region, and re-position the patient's shoul ... | 2008 | 18716586 |
| correlation of thyroid and growth hormones to chromosomal instability in egyptian fanconi anemia patients. | fanconi anemia (fa) is a rare inherited genomic instability syndrome and usually associated with endocrine dysfunctions. we aimed to assess the diagnostic standards of chromosomal instability in fa and to correlate the breakage frequency with the severity of endocrinal dysfunctions. | 2008 | 18716735 |
| bodyweight and carcass characteristics of somali goats fed hay supplemented with graded levels of peanut cake and wheat bran mixture. | the experiment was conducted for ninety days of feeding trial at haramaya university, ethiopia using twenty four yearling male somali goats weighing 20.4 +/- 2.02 (mean +/- sd) with the objectives to evaluate the effect of supplementation of peanut cake and wheat bran mixture (3:1) on body weight (bw) gain and carcass characteristics of somali goats. the experiment was arranged with six blocks and four treatments in a randomized complete block design. the treatments were ad libitum feeding of ha ... | 2008 | 18716913 |
| effects of target concentration infusion of propofol and tracheal intubation on qtc interval. | this study was designed to evaluate the effect of target controlled infusion of propofol on qtc interval and tracheal intubation. twenty-five unpremedicated, asa class i or ii patients were selected and target concentration infusion of propofol at 5 microg x ml(-1) was used throughout the study. the qtc interval was measured before anaesthetic induction (baseline, t1), 10 min after propofol infusion (t2), immediately after tracheal intubation (t3), and 1 min after tracheal intubation (t4). the q ... | 2008 | 18717665 |
| immortalized cortical neurons expressing caspase-cleaved tau are sensitized to endoplasmic reticulum stress induced cell death. | it has been previously reported that an asp421 cleaved form of tau is toxic when expressed in cells. the purpose of this study was to understand if, and in what manner, the presence of asp421 cleaved tau in neurons, which is generated by caspase cleavage, might facilitate neuronal death in alzheimer's disease (ad). for these studies we used immortalized cortical neurons that inducibly express either a full-length tau isoform (t4) or an isoform that has been pseudo-truncated at asp421 (t4c3), to ... | 2008 | 18718455 |
| mice lacking the thyroid hormone receptor-alpha gene spend more energy in thermogenesis, burn more fat, and are less sensitive to high-fat diet-induced obesity. | unable to activate brown adipose tissue (bat) thermogenesis, alphat3-receptor-deficient mice (thra-0/0) are cold intolerant. our objective was to investigate the impact on energy economy and mechanisms of the alternate facultative thermogenesis developed. energy expenditure (oxygen and food consumption) is elevated in thra-0/0 mice reared at room temperature. such difference disappears at thermoneutrality (30 c) and expands as ambient temperature becomes colder (p < 0.001). despite eating more, ... | 2008 | 18719022 |
| astigmatism management in cataract surgery with the acrysof toric intraocular lens. | to present clinical data from a single-center prospective clinical trial of the acrysof toric intraocular lens (iol). | 2008 | 18721707 |
| eeg activity in carmelite nuns during a mystical experience. | mystical experiences relate to a fundamental dimension of human existence. these experiences, which are characterized by a sense of union with god, are commonly reported across all cultures. to date, no electroencephalography (eeg) study has been conducted to identify the neuroelectrical correlates of such experiences. the main objective of this study was to measure eeg spectral power and coherence in 14 carmelite nuns during a mystical experience. eeg activity was recorded from 19 scalp locatio ... | 2008 | 18721862 |
| phase i study of preoperative radiation therapy with concurrent infusional 5-fluorouracil and oxaliplatin followed by surgery and postoperative 5-fluorouracil plus leucovorin for t3/t4 rectal adenocarcinoma: ecog e1297. | oxaliplatin is a platinum analog and radiosensitizer active in colorectal cancer. we performed a phase i trial to test the safety and preliminary efficacy of adding oxaliplatin to standard preoperative chemoradiation therapy for rectal cancer. | 2008 | 18722265 |
| protective effects of vitamin e and curcumin on l-thyroxine-induced rat testicular oxidative stress. | present study examines effects of curcumin and vitamin e on oxidative stress parameters, antioxidant defence enzymes and oxidized (gssg) and reduced glutathione (gsh) levels in testis of l-thyroxine (t4)-induced hyperthyroid rats. the oxidative stress in t4-treated rat testis was evident from elevation in oxidative stress parameters such as lipid peroxide and protein carbonyl contents, decrease in superoxide dismutase (sod) and catalase (cat) activities and increase in glutathione peroxidase (gp ... | 2008 | 18723006 |
| characterization of degqvh, a serine protease and a protective immunogen from a pathogenic vibrio harveyi strain. | vibrio harveyi is an important marine pathogen that can infect a number of aquaculture species. v. harveyi degq (degq(vh)), the gene encoding a degq homologue, was cloned from t4, a pathogenic v. harveyi strain isolated from diseased fish. degq(vh) was closely related to the htra family members identified in other vibrio species and could complement the temperature-sensitive phenotype of an escherichia coli strain defective in degp. expression of degq(vh) in t4 was modulated by temperature, poss ... | 2008 | 18723647 |
| salivary alpha amylase levels under conditions of extreme examination stress. | 11 healthy adult graduate students were studied on two separate occasions 2 wk. apart at the same time of day. self-rating of perceived stress and serial measurements of salivary alpha-amylase levels were performed at t1 = 15 min. before, t2 = 1 min. before, t3 = 1 min. after, and t4 = 15 min. after an event. the events were a highly stressful master's degree oral examination on the first occasion and 15 min. of typing on a computer on the second occasion as a control activity. a kinetic assay w ... | 2008 | 19102470 |
| [expressions of mmp-2 and cox-2 mrna in bladder transitional cell carcinoma and their correlation]. | to determine the levels of mmp-2 and cox-2 mrna in bladder transitional cell carcinoma tissues and explore their relationship. | 2008 | 19102503 |
| [our experiences of preoperative chemo-radiotherapy for t4 primary rectal cancer]. | we reviewed 7 cases of clinical record with preoperative chemo-radiotherapy to evaluate the clinical effectiveness of the chemo-radiotherapy for t4 rectal cancer. the preoperative radiation therapy consisted of 40-45 gy delivered in fractions of 1.8-2.0 gy per day, five days a week. a treatment of 5-fluorouracil, 500 mg/body per day intravenously, or oral uft-e (300 mg/m2) with l-leucovorin (75 mg) per day, or oral s-1 (80 mg/m2) per day five days a week, was given during radiotherapy. grade 1 o ... | 2008 | 19106509 |
| [two cases of advanced gastric cancer with postoperative severe complications after neo-adjuvant chemotherapy]. | we report two cases of advanced gastric cancer with severe postoperative complications after neo-adjuvant chemotherapy (nac). the first case is a 60-year-old man who was diagnosed as a type 2 advanced gastric cancer with paraaortic lymph node metastases and the elevation of serum ca19-9 level. nac was started, but no reductions were noted after 3 courses. palliative total gastrectomy with distal pancreatectomy, splenectomy, cholecystectomy, and partial hepatectomy for t4 gastric cancer exhibitin ... | 2008 | 19106528 |
| [s-1+gemcitabine (gem) therapy was effective in a case of unresectable pancreatic head carcinoma]. | treatment results of pancreatic head carcinoma are not good and long-term survival, especially in nonresectable cases is extremely difficult to obtain. the case reported here is of nonresectable pancreatic head carcinoma in which s-1+gemcitabine (gem) proved to be effective. | 2008 | 19106543 |
| [clinical study on multi-segmental pedicle screw implantation in the treatment of middle-upper thoracic spine fracture and dislocation]. | to review a group of clinical data of pedicle screw implantation in the treatment of middle-upper thoracic fracture and dislocation and explore these clinical effect. | 2008 | 19108376 |
| a general and efficient method for the site-specific dual-labeling of proteins for single molecule fluorescence resonance energy transfer. | a general strategy for the site-specific dual-labeling of proteins for single-molecule fluorescence resonance energy transfer is presented. a genetically encoded unnatural ketone amino acid was labeled with a hydroxylamine-containing fluorophore with high yield (>95%) and specificity. this methodology was used to construct dual-labeled t4 lysozyme variants, allowing the study of t4 lysozyme folding at single-molecule resolution. the presented strategy is anticipated to expand the scope of single ... | 2008 | 19108697 |
| bioequivalence of two levothyroxine tablet formulations without and with mathematical adjustment for basal thyroxine levels in healthy argentinian volunteers: a single-dose, randomized, open-label, crossover study. | levothyroxine has a narrow therapeutic index; therefore, precise and accurate assessment of the bioequivalence of different levothyroxine products is critical. bioavailability estimates of levothyroxine formulations might be affected by baseline concentrations of the hormone. | 2008 | 19108789 |
| the combination of low-dose levobupivacaine and fentanyl for spinal anaesthesia in ambulatory inguinal herniorrhaphy. | this study investigated whether the addition of 25 microg intrathecal fentanyl to levobupivacaine spinal anaesthesia for outpatient inguinal herniorrhaphy allows a sub-anaesthetic levobupivacaine dose to be used. forty patients were assigned to receive 5 mg levobupivacaine 0.5% mixed with 25 microg fentanyl (group lf) or 7.5 mg levobupivacaine 0.5% (group l). the highest sensory block levels achieved were t7 (range t5 - t9) and t6 (range t4 - t9) in groups lf and l, respectively. the times to tw ... | 2008 | 19094438 |
| [hypothyroidism and terminal renal failure in the neonatal period]. | it has been described alterations of the thyroid function in patients with chronic renal disease without primary disease of the thyroid gland. nevertheless primary hypothyroidism is more frequent in this population than in other non renal chronic disease. authors report two cases of hypothyroidism diagnosed in infants with terminal renal failure in the neonatal period, secondary to renal hypoplasia / dysplasia, both in peritoneal dialysis programme. the diagnosis was made by elevated value of th ... | 2008 | 19094814 |
| annual variations of quantitative eeg in patients with chronic epilepsy. | annual changes in powers of the close-eyed eeg were measured over 12 months in 12 patients with epilepsy. | 2008 | 19095583 |
| spontaneous spinal epidural hematoma in an infant : a case report and review of the literature. | spontaneous spinal epidural hematoma (sseh) is rare in children, especially in infants, in whom only 12 cases have been reported. because of the nonspecificity of presenting symptoms in children, the diagnosis may be delayed. we report herein a case of sseh in a 20-month-old girl who initially presented with neck pain, and developed lower extremity motor weakness and symptoms of neurogenic bladder 2 weeks prior to admission. the magnetic resonance imaging showed an epidural mass lesion extending ... | 2008 | 19096698 |
| propofol infusion shortens and attenuates oxidative stress during one lung ventilation. | resuming two lung ventilation (2lv) from one lung ventilation (olv) has been proven to induce significant oxidative stress, mainly by superoxide release. although total intravenous anesthesia and inhalational anesthesia are both used in thoracic surgery, different anesthetics may alter the oxidant/antioxidant balance. | 2008 | 19097962 |
| neurological impairment following myocardial ischemia associated with postoperative epidural analgesia. | although epidural analgesia reduces the postoperative stress response and provides good pain relief for patients, potential complications associated with the technique may decrease its acceptability for some patients. we describe a 76-year-old female who underwent surgery for carcinoma of the urinary tract. postoperative epidural analgesia was performed at the postanesthesia care unit. neither a repeat attempt nor accidental dural puncture was encountered during the procedure. unfortunately, she ... | 2008 | 19097969 |
| impact of microenvironment on the growth of primary human epidermal cells. | although the conditions for in vitro cultivation of adult stem cells and tissue are easily standardized, little is known about the optimal conditions for biointegration after transfer of the tissue graft, playing an important role in the treatment of defects especially soft-tissue skin injuries. to examine the influence of the microenvironment, we investigated the doubling time of primary epithelial cells in relation to the culture medium. serum from patients of different age groups (n = 15, <20 ... | 2008 | 19098543 |
| circulating cell-free dna in plasma of locally advanced rectal cancer patients undergoing preoperative chemoradiation: a potential diagnostic tool for therapy monitoring. | circulating cell-free dna opens up an interesting field for therapy monitoring, in particular during multimodal therapy protocols. the objective of this proof of principle study was to evaluate whether the amount of circulating plasma dna has the potential to serve as a marker for therapy monitoring during the treatment course of locally advanced rectal cancer patients. we especially focused on kinetics of circulating dna to assess whether variances in kinetics have the potential to discriminate ... | 2008 | 19096128 |
| a charged performance by gp17 in viral packaging. | packaging of viral genomes into virus capsids requires powerful motors to overcome the repulsive force that builds as the nucleic acids are compressed. through structural analyses of the t4 bacteriophage packaging motor gp17, sun et al. (2008) now propose a packaging mechanism in which electrostatic forces cause the motor to alternate between tensed and relaxed conformational states. | 2008 | 19109888 |
| the structure of the phage t4 dna packaging motor suggests a mechanism dependent on electrostatic forces. | viral genomes are packaged into "procapsids" by powerful molecular motors. we report the crystal structure of the dna packaging motor protein, gene product 17 (gp17), in bacteriophage t4. the structure consists of an n-terminal atpase domain, which provides energy for compacting dna, and a c-terminal nuclease domain, which terminates packaging. we show that another function of the c-terminal domain is to translocate the genome into the procapsid. the two domains are in close contact in the cryst ... | 2008 | 19109896 |
| local lattice distortion in the giant negative thermal expansion material mn3cu1-xgexn. | giant negative thermal expansion is achieved in antiperovskite manganese nitrides when the sharp volume change associated with magnetic ordering is broadened by substitution. in this letter, we address the unique role of the ''magic" element, ge, for such broadening in mn3cu1-xgexn. we present evidence for a local lattice distortion well described by the low-temperature tetragonal (t4) structure of mn3gen for a range of x, where the overall structure remains cubic. this structural instability sh ... | 2008 | 19113356 |
| the immediate effects of upper thoracic translatoric spinal manipulation on cervical pain and range of motion: a randomized clinical trial. | this study examined the effect of translatoric spinal manipulation (tsm) on cervical pain and cervical active motion restriction when applied to upper thoracic (t1-t4) segments. active cervical rotation range of motion was measured re- and post-intervention with a cervical inclinometer (crom), and cervical pain status was monitored before and after manipulation with a faces pain scale. study participants included a sample of convenience that included 32 patients referred to physical therapy with ... | 2008 | 19119394 |
| use of diode laser 980 nm as adjunctive therapy in the treatment of chronic periodontitis. a randomized controlled clinical trial. | the primary goal of periodontal therapy is the removal of supra and subgingival bacterial deposits by mechanical debridement consisting in scaling and root-planing (srp) using manual or power-driven instruments. the complete removal of bacteria and their toxins from periodontal pockets is not always achieved with conventional mechanical treatment. the use of lasers as an adjunctive therapy for periodontal disease may improve tissue healing by bactericidal and detoxification effects. the aim of t ... | 2008 | 19123307 |
| [effects of different irrigation treatments on photosynthesis of tieguanyin tea plants]. | by using chlorophyll fluorescence kinetics technique, the effects of different irrigation intervals, i.e., 5 d (t1), 10 d (t2), 15 d (t3), 20 d (t4), and 25 d (t5), on the photosynthesis of 2-year tieguanyin tea plants were investigated in the field, with no irrigation as the control. the results showed that the leaf water potential and chlorophyll content decreased with increasing irrigation interval, while the net photosynthesis (p) increased first and decreased then, reaching its highest valu ... | 2008 | 19123345 |
| neck dissection following concurrent chemoradiation for advanced head and neck carcinoma: pathologic findings and complications. | to assess the rate of pathologic residual neck disease and complication rates following selective neck dissection in patients with advanced head and neck carcinoma after concurrent chemotherapy (ct) and radiation therapy (rt). | 2008 | 19128575 |
| [influence of maternal hypothyroxinaemia during pregnancy on psychomotor development]. | the maternal thyroid function during early pregnancy plays a fundamental role in foetal brain development as synthesis of thyroid hormone does not begin until the 20th week of gestation. | 2008 | 19128742 |
| the frequency of autoimmune thyroid disorders in juvenile idiopathic arthritis. | few studies have been performed to investigate autoimmune diseases associated with organ non-specific rheumatological disorders in children, such as juvenile idiopathic arthritis (ia). the objective in this study was to determine the frequency of autoimmune diseases of the thyroid gland in children with jia. eighty patients with jia and 81 healthy sex- and age-matched controls were enrolled in the study. serum free t3, free t4, thyroid stimulating hormone (tsh), anti-thyroglobulin antibodies, an ... | 2008 | 19102051 |
| [compare of laparoscopic and open surgery for radical cystectomy with orthotopic ileal neobladder]. | to compare the clinical therapeutic effect and complications of laparoscopic radical cystectomy with orthotopic ileal neobladder (lrc-inb) with open radical cystectomy with orthotopic ileal neobladder (orc-inb). | 2008 | 19134373 |
| impact of organic solvents and environmental pollutants on the physiological function in petrol filling workers. | long term exposure to solvents and air pollutants can lead to deleterious effects on respiratory, haematological and thyroid functioning. the aim of this study was to investigate whether chronic exposure to solvents like benzene and pollutants like carbon monoxide in petrol filling workers had adverse effect on blood parameters, thyroid and respiratory functions. the study group consisted of 42 healthy, non-smoker petrol filling workers, aged 20-50 years with work (exposure) duration from 2-15 y ... | 2008 | 19139531 |
| neoadjuvant chemoradiotherapy with 5-fluorouracil by bolus. | neoadjuvant chemoradiotherapy (ct-rt) with continuous infusion (c.i.) 5-fluorouracil (5-fu) before resection of high-risk rectal cancer improves overall survival (os) and pelvic control. since the presence of cardiomiopathy may contraindicate c.i. of 5-fu, an alternative regimen of 5-fu ct-rt was prospectively studied in these patients. | 2008 | 19192666 |
| effects of modified ultrafiltration on coagulation as measured by the thromboelastograph. | hemodilution during cardiopulmonary bypass (cpb) continues to be a cause of morbidity associated with coagulation dysfunction, bleeding, and allogeneic blood transfusion. clot formation and strength have been shown to impact bleeding and transfusions. strategies to reduce hemodilution may be negated based on the course of the cardiac procedure itself. modified ultrafiltration (muf) is commonly used in pediatric cardiac surgery; however, it is not well accepted in adult surgery. this study aimed ... | 2008 | 19192750 |
| orbital metastasis as primary clinical manifestation of thyroid carcinoma--case report and literature review. | capillary thyroid carcinoma (ptc) is the most common neoplasm of thyroid. it usually grows slowly and is clinically indolent; although rare, its aggressive forms with local invasion or distant metastases can occur. metastatic thyroid carcinoma rarely involves the orbit. we reported an uncommon case of orbital metastasis of ptc. a 66-years-old woman presented proptosis of the right eye. the biopsy of the tumor in orbit revealed metastatic thyroid carcinoma. the ultrasensitive tsh level was 1,34 m ... | 2008 | 19197459 |
| detection of circulating autoantibodies against thyroid hormones in an infant with permanent congenital hypothyroidism and her twin with transient congenital hypothyroidism: possible contribution of thyroid hormone autoantibodies to neonatal and infant hypothyroidism. | premature, very-low-birth-weight female twins were diagnosed with congenital hypothyroidism (ch). thyroid hormone antibodies (thab) directed against triiodothyronine (t3) and thyroxine (t4) of both the igm and igg class were detected in both twins. at age 10 months, a rise in thyroid stimulating hormone (tsh) occurred in both infants and measurement of thab at the same time revealed the appearance of igm-t4 and igg-t4 and an increase in igg-t3 levels in twin 1 (permanent ch), and with a slight i ... | 2008 | 19209623 |
| thyroxine as a stimulator of liver regeneration after partial hepatectomy: an experimental animal study. | twenty six male albino rats were divided into a control group (6rats) (g) exposed to sham operation and two experimental groups (g1 & g2) of 10 rats each. 2/3 partial hepatectomy (ph) was performed in g1 and t4 was administered orally in a dose of 4 mg/kg 10 days prior to ph in g2. animals were sacrificed 24 hours following ph and sham operation. liver sections were immunohistochemically stained for anti-cyclin d1 & anti-vegf antibodies. positive reaction was in the nuclei of hepatocytes and in ... | 2008 | 19209768 |
| [resolution of thyroxine hormone enantiomers by precolumn derivatization with a fluorescent chiral reagent using reversed-phase high performance liquid chromatography]. | a highly fluorescent chiral tagging reagent, r(-)-4-(n,n-dimethylaminosulfonyl)-7-(3-isothiocy-anatopyrrolidino)-2,1,3-benzoxadiazole (r(-)-dbd-pyncs), was employed for the enantiomer separation of thyroxine hormone, d,l-3,5,3',5'-tetraiodothyronine (t4) and l-3,5,3'-triiodothyronine (t3). the reaction of r(-)-dbd-pyncs with the thyroxine enantiomers was carried out at 40 degrees c for 20 min under a basic medium surrounding to yield the corresponding pair of diastereomers. no racemization occur ... | 2008 | 19160753 |
| [extended supracricoid partial laryngectomy with tracheocricohyoidoepiglottopexy and tracheocricohyoidoglottopexy]. | to investigate the surgical procedure and indication of the extended supracricoid partial laryngectomy with tracheocricohyoidoepiglottopexy and tracheocricohyoidoglottopexy (escpl+-tchep/tchp) as well as the rehabilitation of laryngeal functions. | 2008 | 19166032 |
| e449x mutation in the thyroid hormone receptor beta associated with autoimmune thyroid disease and severe neuropsychomotor involvement. | to report the clinical and molecular aspects of a patient with a diagnosis of resistance to thyroid hormone (rth) harboring the e449x mutation associated with autoimmune thyroid disease and severe neuropsychomotor retardation. | 2008 | 19169471 |
| a novel mutation of thyroid hormone receptor beta (i431v) impairs corepressor release, and induces thyroid hormone resistance syndrome. | resistance to thyroid hormone (rth) is a rare disorder characterized by variable tissue hyporesponsiveness to thyroid hormone, usually caused by mutations in the thyroid hormone receptor beta (trbeta). we describe a large brazilian family harboring a novel mutation affecting trbeta gene and inducing rth. a 14-year-old girl was found to have elevated free t4 and free t3 plasma concentrations in coexistence with unsuppressed tsh and a questionable goiter. the diagnosis of rth was verified by ident ... | 2008 | 19169485 |
| [prognostic implication of common bile duct infiltration in adenocarcinoma of the ampulla of vater after pancreaticoduodenectomy]. | to investigate the prognostic implication of common bile duct infiltration in the adenocarcinoma of the ampulla of vater after panreaticoduodenectomy. | 2008 | 19173811 |
| [thyroid-induced hyperthyroidism yin-deficiency model of rats]. | to establish a rat model of hyperthyroidism yin-deficiency. | 2008 | 19180970 |
| dual-phase 99mtc-mibi parathyroid imaging reveals synchronous parathyroid adenoma and papillary thyroid carcinoma: a case report. | the possibility of a coincidental appearance of hyperparathyroidism and thyroid cancer is not often considered because of its low incidence. here, we present a case of a 49-year-old woman with a parathyroid adenoma coexisting with two sites of papillary thyroid carcinoma. dual-phase 99mtc-methoxyisobutylisonitrile (mibi) parathyroid imaging before the operation correctly visualized the site of the parathyroid adenoma. in addition, two papillary thyroid carcinomas showed faint uptake of 99mtc-mib ... | 2008 | 19181586 |
| relation between thyroid hormone concentration and serum levels of interleukin-6 and interleukin-10 in patients with nonthyroidal illness including chronic kidney disease. | we evaluated relations between interleukins (il) il-6 and il-10 and euthyroid sick syndrome (ess) in patients with nonthyroidal illness (nti). | 2008 | 19367004 |
| [the value of endorectal ultrasonography in rectal cancer staging]. | preoperative staging of rectal cancer is considered essential to select patients adequately for different therapeutic regimes. the aim of the present study was to evaluate the accuracy of endorectal ultrasonography in preoperative staging of rectal cancer. | 2008 | 19368271 |
| biochemical characterization of four novel mutations in the thyroid hormone receptor beta gene in patients with resistance to thyroid hormone. | in resistance to thyroid hormone (rth), decreased tissue responsiveness to thyroid hormones is usually caused by mutations in the thyroid hormone receptor beta (thrb) gene. subsequently, in serum the level of thyroid stimulating hormone (tsh) is not suppressed despite increased concentrations of thyroxine (t4) and triiodothyronine (t3). in our laboratory, dna sequences of exon 7 to 10 in the thrb gene have been analysed in individuals with biochemical signs of rth. four novel point mutations wer ... | 2008 | 19378427 |
| [pharyngocutaneous fistula after total laryngectomy: incidence, predisposing factors, and treatment]. | we investigated the incidence and etiologic factors of pharyngocutaneous fistulas occurring after total laryngectomy. | 2008 | 19293623 |
| ossification of the thoracic ligamentum flavum in an achondroplastic patient: a case report. | we report a case of spinal stenosis with ossification of the thoracic ligamentum flavum in a 53-year-old man with achondroplasia. neurological signs indicated flaccid paralysis below l1, and the patient was unable to walk. ossification of the ligamentum flavum was observed at t4/5 and t9 to t12, compressing the thecal sac. laminectomy of t9 to l1 was performed. at one-year follow-up, the patient was able to walk with one elbow crutch. | 2008 | 19126915 |
| an adolescent boy with thalassemia major presenting with bone pain, numbness, tetanic contractions and growth and pubertal delay: panhypopituitarism and combined vitamin d and parathyroid defects. | a 16-year-old boy with transfusion-dependent thalassemia major presented with tetany, numbness, bone pain, short stature and pubertal delay. his height sds score=-2.6, bmi=22.4, spleen was palpable 5 cm and liver 7 cm below the costal margins. the cardio-vascular examination was normal. laboratory investigations showed a hemoglobin level (8 g/dl), hypocalcemia, hyperphosphatemia and elevated alkaline phosphatase (alp) with serum 25-oh d below 3 ng/ml and a normal magnesium level. serum parathyro ... | 2008 | 19337171 |
| [endocrine effects of antiepileptic drugs]. | both seizures and antiepileptic drugs may induce disturbances in hormonal system. regarding endocrine effects of anticonvulsants, an interaction of these drugs with gonadal, thyroid, and adrenal axis deserves attention. since majority of antiepileptic drugs block voltage dependent sodium and calcium channels, enhance gabaergic transmission and/or antagonize glutamate receptors, one may expect that similar neurochemical mechanisms are engaged in the interaction of these drugs with synthesis of hy ... | 2008 | 19205363 |
| [pendred syndrome among patients with hypothyroidism: genetic diagnosis, phenotypic variability and occurrence of phenocopies]. | pendred syndrome (omim274600) is one of the causes of congenital hypothyroidism due to thyroid dyshormonogenesis. it is an autosomal recessive disease classically characterized by dyshormonogenetic goitre and sensorineural deafness. it is caused by mutations in pds/slc26a4 gene encoding for pendrin--an anion transporter, mostly expressed in the thyroid gland and the inner ear. the thyroid impairment in pendred syndrome develops only in 80% of affected individuals in form of a euthyroid or hypoth ... | 2008 | 19235486 |
| prevalence of post-partum thyroiditis in liguria (italy): an observational study. | post-partum thyroiditis (ppt) is an autoimmune disorder occurring within the first year following delivery. a variable prevalence has been reported in different surveys. we prospectively evaluated ppt prevalence and outcome in a cohort of pregnant women living in a well-defined geographic area. | 2008 | 19246971 |
| [postural stability after head-shaking in the healthy young individuals]. | to investigate the postural stability after head-shaking in the normal young individuals. | 2008 | 19266816 |
| [refined staging in hilar bronchial neoplasms with ecg-gated multislice-ct---case report]. | equivocal initial ct-based staging in 2 patients with hilar bronchial neoplasms was reassessed with retrospective ecg-gated multislice-ct and optimized examination parameters prior to definition of treatment. an initially suspected irresectable t4 tumor with mediastinal infiltration was downstaged to t2 in one case, while tumor infiltration into the left atrium could be confirmed in the other case. in doubtful conditions, ecg-gated multislice ct with optimized examination parameters may be helpf ... | 2008 | 19294876 |
| [the expression and significance of integrin beta1 and focal adhesion kinase and its clinical value in laryngeal carcinoma]. | to study the expressions and clinical significance of integrin beta1 and focal adhesion kinase (fak) in laryngeal carcinoma (lscc). | 2008 | 19297850 |
| effect of highly active antiretroviral therapy on cd4 count and weight in aids patients seen at the uith, ilorin. | to determine the response on treatment-naïve hiv/aids patients to the highly active antiretroviral therapy (haart) in terms of cd4 count and weight gain over a period of 2 1/2 years. | 2008 | 19320401 |