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effect of pre-operative physiotherapy in patients with end-stage osteoarthritis undergoing hip arthroplasty.to examine the effect of pre-operative physiotherapy before hip arthroplasty in patients with end-stage hip osteoarthritis.200818955429
ct staging of colon cancer.computer tomography (ct) has been the principal investigation in the staging of colon cancers. the information obtained with routine ct has been limited to identifying the site of the tumour, size of the tumour, infiltration into surrounding structures and metastatic spread. the foxtrot trial national cancer research institute (ncri) has been specifically designed to evaluate the efficacy of neoadjuvant treatment in colon cancers by using preoperative chemotherapy with or without an anti-epiderm ...200818996269
chemoradioimmunotherapy with 5-fluorouracil, cisplatin and interferon-alpha in pancreatic and periampullary cancer: results of a feasibility study.recent studies give rise to the hypothesis, that adjuvant chemoradioimmunotherapy with 5-fluorouracil (5-fu), cisplatin and interferon-alpha (ifn-alpha) might be a possible new treatment of pancreatic cancer in resected patients. we report the up-to-now experience at our institution.200818996727
diagnostic confusion attributable to spurious elevation of both total thyroid hormone and thyroid hormone uptake measurements in the setting of autoantibodies: case report and review of related literature.to review the effect of thyroid autoantibodies on thyroid function assays and to present a case in which thyroid autoantibodies resulted in spurious assay readings for both total thyroid hormone levels and thyroid hormone uptake measurements.200818996795
serum concentrations of adiponectin and resistin in hyperthyroid graves' disease patients.this study was undertaken to determine whether serum adiponectin and resistin levels are influenced by hyperthyroidism and autoimmune factors and to find out whether their levels are dependent on the presence of ophthalmopathy. we measured serum concentrations of adiponectin and resistin in 76 patients (63 women, 13 men) with graves' disease (gd) and compared them with levels of the control group which consisted of 30 healthy subjects. patients were separated into two groups according to the pre ...200818997483
hypothyroidism is associated with increased myostatin expression in rats.besides its key role in the regulation of muscle growth during development, myostatin also appears to be involved in muscle homeostasis in adults, and its expression is upregulated during muscle atrophy. since muscle physiology is greatly influenced by thyroid status, and the myostatin promoter region contains several putative thyroid hormone response elements, in the present study we examined the possible role of thyroid hormones in the regulation of myostatin gene expression. adult male rats w ...200818997488
spinal curvature: comparison of frontal measurements with the spinal mouse and radiographic assessment.the spinal mouse is an external non-invasive device which measures the spinal shape and mobility of the spine in several planes. the aim of the present study was to evaluate the reliability and the validity of the spinal mouse to assess frontal standing measurements of the spine in a sample of young healthy volunteers.200818997653
critical slowing down in polymer dynamics near the coil-stretch transition in elongation flow.we present experimental results on relaxation dynamics of lambda-dna and t4 polymer molecules toward a steady state in elongation flow. strong critical slowing down (similar to the well-known effect in continuous phase transitions) in polymer relaxation near the coil-stretch transition (cst) is quantitatively investigated and found to be in good accord with predictions. for polymers with a small number of kuhn segments the maximum of the relaxation time vs the strain rate provides precise inform ...200818999371
disposition and safety of zonisamide after intravenous and oral single dose and oral multiple dosing in normal hound dogs.the purpose of this study was to determine an oral dosing regimen of zonisamide in healthy dogs such that therapeutic concentrations would be safely reached and maintained at steady-state. adult hound dogs (n = 8) received a single iv (6.9) and an oral (po) dose (10.3 mg/kg) using a randomized cross-over design. zonisamide was then administered at 10.3 mg/kg po every 12 h for 8 weeks. zonisamide was quantitated in blood compartments or urine by hplc and data were subjected to noncompartmental ph ...200819000278
identification of the 18s-ribosomal-dna genotypes of acanthamoeba isolates from the philippines.cyst morphology has been commonly used to identify the free-living amoeba acanthamoeba to subgenus level. a more accurate and consistent method, based on the sequence analysis of the gene coding for the amoeba's small-subunit ribosomal rna (rns), has, however, been developed. there have been no attempts to identify the acanthamoeba genotypes circulating in the philippines. in this study, therefore, the asa.s1 region of the rns gene from 17 acanthamoeba isolates, collected from soil, water and co ...200819000384
[changes in alpha2-adrenergic receptors gene expression after high-level spinal cord injury in wistar rats].to evaluate the change in alpha(2)-adrenergic receptors (alpha(2)-ars) gene expression after high-level injury of the spinal cord (sci), aiming as developing a more effective perioperative anesthetic management for high-level sci patients.200819000416
[effect of fructose-1,6-diphosphete on myocardial preservation during pulmonary operations].to investigate the effect of fructose-1,6-diphosphete(fdp) on myocardial preservation in pulmonary operations.200819001742
[the assessment of acute phase proteins as prognostic factors in patients surgically treated for non-small cell lung cancer].the aim of the study was to assess quantitative changes of the acute phase protein (app) serum level in patients with non-small cell lung cancer (nsclc) who underwent a radical resection. we analysed the correlation between quantitative app changes and: the survival rate, the histological type of the cancer, tnm stage and grading.200819003761
nmr data do not implicate a phosphorane in the t4 dna ligase reaction. 200819004796
[work stress, health and satisfaction of life in young doctors. results of a longitudinal study in switzerland].based on the effort-reward-imbalance model by siegrist a study was undertaken to find out (a) in what way young doctors assess effort and reward during their specialist training; (b) whether there are certain job stress patterns over time; and (c) what the correlations are, if any, between perceived job stress, health and satisfaction with life.200819006042
structural correlates of the temperature sensitive phenotype derived from saturation mutagenesis studies of ccdb.temperature sensitive (ts) mutants are widely used to reversibly modulate protein function in vivo and to understand functions of essential genes. despite this, little is known about the protein structural features and mechanisms responsible for generating a ts phenotype. also, such mutants are often difficult to isolate, limiting their use. in this study, a library consisting of 75% of all possible single-site mutants of the 101-residue, homodimeric escherichia coli toxin ccdb was constructed. ...200819006334
re-irradiation of head and neck carcinoma.to determine the efficacy of re-irradiation of patients with head and neck carcinoma we reviewed the pertinent literature. depending on the location and extent of the tumor, re-irradiation may be accomplished with external beam radiotherapy (rt), brachytherapy, intraoperative rt, and/or radiosurgery. the likelihood of cure is impacted by the interval between the initial course of rt and re-irradiation, whether the carcinoma is a recurrence or a second primary tumor, initial t-stage, and recurren ...200818846001
amiodarone-induced thyrotoxicosis. a review.amiodarone (am), a potent class iii anti-arrhythmic drug, is an iodine-rich compound with a structural resemblance to thyroid hormones triiodothyronine (t3) and thyroxine (t4). at the commonly employed doses, am causes iodine overload up to 50-100 times the optimal daily intake, which may be responsible of a spectrum of effects on thyroid function often counterbalancing its heart benefits. although most patients on chronic am treatment remain euthyroid, a consistent proportion may develop thyrot ...200818846027
prevalence of hypothyroidism and importance of cholesterol estimation in patients suffering from major depressive disorder.the coexistence of hypothroidism and depression is already reported and both of these conditions are known to share some common clinical symptoms. serum cholesterol level is known to be altered in either condition considered separately. but, no report is obtained regarding serum cholesterol level when both the conditions coexist. in this study, 78 patients (61 females and 17 males, age ranged 19 to 67 years) suffering from major depressive disorder were included. serum t3, t4, tsh and cholestero ...200818828343
relationship between the hypothalamic-pituitary-thyroid axis and alcohol craving in alcohol-dependent patients: a longitudinal study.a relationship between some hypothalamic-pituitary-related hormones and craving for alcohol has been suggested, leading to hypothesize a role of some hormones in the neurobiology of alcohol dependence. investigating this association in alcohol-dependent (ad) patients was the aim of this preliminary and exploratory study.200818828809
upstaging benefits and accuracy of sentinel lymph node mapping in colorectal adenocarcinoma nodal staging.sentinel lymph node (sln) mapping is an additional method for improving colorectal cancer nodal staging. the purpose of the study was to define the method's accuracy in nodal staging, its upstaging benefits and to identify the predictive factors for its failure.200818618578
[crossed pattern of sensory loss with left thoracic level in a right dorsolateral medullary infarction].introduction: medullary infarctions as consequence of vertebro-basilar strokes are frequent findings in clinical practice. medulla oblongata, the lowest segment of the brainstem, is a dense anatomic structure with different conglomerate of nuclei, ascending and descending pathways within a very small area and tiny insults can present with expressive clinical manifestations. sensory dysfunction is often a noteworthy element in lateral medullary infarctions and its distribution depends of the site ...200818841547
prevalence of hypothyroidism in recurrent pregnancy loss in first trimester.to determine the frequency of hypothyroidism in women with recurrent pregnancy loss in first trimester in the indian population.200818923214
anaplastic thyroid cancer: prevalence, diagnosis and treatment.anaplastic thyroid cancer (atc) is a rare aggressive tumor arising from the follicular cells of the thyroid gland (as does well differentiated thyroid cancer, wdtc), but atc cells do not retain any of the biological features of the original follicular cells, such as uptake of iodine and synthesis of thyroglobulin. prognosis is almost invariably fatal. in this article the authors review the pathology, epidemiology, clinical presentation, diagnosis and treatment options of atc. atc incidence typic ...200818923370
the ontogeny of drug metabolizing enzymes and transporters in the rat.knowledge of the ontogeny of the various systems involved in distribution and elimination of drugs is important for adequate interpretation of the findings during safety studies in juvenile animals. the present study was designed to collect information on plasma concentrations of total protein and albumin, enzyme activity and mrna expression of cytochrome p450 isoenzymes (cyp1a1/2, cyp2b1/2, cyp2e1, cyp3a1/2, and cyp4a1), carboxylesterase and thyroxin glucuronidation (t4-gt) activity in liver mi ...200818926897
[effect of danhong injection on cerebral injury in patients undergoing coronary artery bypass graft operation with extracorporeal circulation].to investigate the effect and its possible mechanisms of danhong injection (dhi) on cerebral injury during coronary artery bypass graft (cabg) operation with hypothermic cardiopulmonary bypass (cpb).200818928094
phase ii trial of paclitaxel, carboplatin and gemcitabine in patients with locally advanced carcinoma of the bladder.this 2-arm phase ii multicenter trial was designed to assess the efficacy and toxicity of neoadjuvant paclitaxel, gemcitabine and carboplatin in patients with invasive bladder cancer.200818930256
quality of life in men with locally advanced adenocarcinoma of the prostate: an exploratory analysis using data from the capsure database.we present longitudinal quality of life outcomes in a national observational cohort of men with locally advanced prostate adenocarcinoma.200818930270
[a case of long survival in stage iv gastric carcinoma responding to combination treatment with paclitaxel and 5- fluorouracil followed by surgical resection].a 62-year-old female with epigastric pain was diagnosed with type 4 gastric cancer upon detailed examination. abdominal computed tomography(ct)revealed metastasis to the paraaortic lymph node and ascites at pelvis, and aspiration cytology of the ascites through vagina was positive(cy1). the clinical stage was determined as t4(panc) n1h0p0cy1m1(lym), cstageiv. three courses of neoadjuvant chemotherapy combined with paclitaxel and 5-fluorouracil( ft therapy)were performed. ft therapy showed a subs ...200818931580
[a case of bilateral t4 breast cancer with different responses to chemotherapy].it is recognized that hormone receptors and her2 are important as prognostic factors in breast cancer. moreover, it seems likely that hormone receptors and her2 are important predictive factors for response to chemotherapy in breast cancer. we report a case of bilateral t4 breast cancer with different expression for hormone receptors and her2. the patient was a 67-year-old woman. the stage was t4bn2am0, respectively. the right tumor was negative for hormone receptors and positive for her2, while ...200818931591
repetitive lagging strand dna synthesis by the bacteriophage t4 replisome.our studies on the t4 replisome build on the seminal work from the alberts laboratory. they discovered essentially all the proteins that constitute the t4 replisome, isolated them, and measured their enzymatic activities. ultimately, in brilliant experiments they reconstituted in vitro a functioning replisome and in the absence of structural information created a mosaic as to how such a machine might be assembled. their consideration of the problem of continuous leading strand synthesis opposing ...200818931782
the history of a developmental stage: metamorphosis in chordates.metamorphosis displays a striking diversity in chordates, a deuterostome phylum that comprises vertebrates, urochordates (tunicates), and cephalochordates (amphioxus). in anuran amphibians, the tadpole loses its tail, develops limbs, and undergoes profound changes at the behavioral, physiological, biochemical, and ecological levels. in ascidian tunicates, the tail is lost and the head tissues are drastically remodeled into the adult animal, whereas in amphioxus, the highly asymmetric larva trans ...200818932261
characteristics associated with swallowing changes after concurrent chemotherapy and radiotherapy in patients with head and neck cancer.to define factors that acutely influenced swallowing function prior to and during concurrent chemotherapy and radiotherapy.200818936351
comparison of 2% lignocaine with adrenaline and fentanyl, 0.75% ropivacaine and 0.5% levobupivacaine for extension of epidural analgesia for urgent caesarean section after low dose epidural infusion during labour.low dose local anaesthetic and fentanyl epidural solutions are commonly 'topped-up' for urgent caesarean section. however, the block characteristics associated with newer local anaesthetics such as ropivacaine 0.75% and levobupivacaine 0.5% have not been fully determined. in a randomised double-blinded controlled clinical trial, we compared 2% lignocaine with adrenaline and fentanyl (laf), 0.75% ropivacaine and 0.5% levobupivacaine for extension of low dose epidural analgesia for urgent caesarea ...200818853583
kinetics of olfactory function following endonasal sinus surgery for nasal polyposis.sinus surgery is known to improve olfactory function in patients with nasal polyposis. however, little is known about the kinetics of this process.200818853868
coarse-graining protein structures with local multivariate features from molecular dynamics.a multivariate statistical theory, local feature analysis (lfa), extracts functionally relevant domains from molecular dynamics (md) trajectories. the lfa representations, like those of principal component analysis (pca), are low dimensional and provide a reduced basis set for collective motions of simulated proteins, but the local features are sparsely distributed and spatially localized, in contrast to global pca modes. one key problem in the assignment of local features is the coarse-graining ...200818855436
birth delivery mode modifies the associations between prenatal polychlorinated biphenyl (pcb) and polybrominated diphenyl ether (pbde) and neonatal thyroid hormone levels.developing infants may be especially sensitive to hormone disruption from chemicals including polychlorinated biphenyls (pcbs) and polybrominated diphenyl ethers (pbdes).200818941581
characteristics of colorectal cancer in young patients at an urban county hospital.colorectal cancer (crc) is a disease primarily affecting an older population. the incidence of crc in young patients has been rising. the purpose of this study was to evaluate the characteristics of crc in an ethnically diverse, young population. two groups of patients with crc (40 years old or younger and 60 years old or older) treated from 1998 to 2005 were retrospectively evaluated. forty-one young patients with crc were identified. hispanics constituted 51 per cent of the young population. f ...200818942625
a simplified tumor regression grade correlates with survival in locally advanced rectal carcinoma treated with neoadjuvant chemoradiotherapy.locally advanced rectal cancer is frequently treated with neoadjuvant chemoradiotherapy to reduce local recurrence and possibly improve survival. the tumor response to chemoradiotherapy is variable and may influence the prognosis after surgery. this study assessed tumor regression and its influence on survival in patients with rectal cancer treated with chemoradiotherapy followed by curative surgery.200818846402
[in vivo study of fidelity of dna double-strand break repair in bacteriophage t4].a method for in vivo studying the fidelity of dna double-strand break (dsb) repair in bacteriophage t4 has been developed. the frequency of reversion of rii mutations to the wild phenotype was measured in i segc+ x i ets 1 segcdelta crosses, where ets 1 is an insertion in the initial part of the rii gene carrying a sequence recognized by segc endonuclease; i designates a riib or riia mutation located at some distance from ets 1, and segcdelta is a deletion in the segc gene. in such cross, a dsb ...200818846814
staging esophageal cancer.accurate staging of disease is necessary in patients with newly diagnosed esophageal cancer in order to prompt appropriate curative or palliative therapy. computed tomography (ct) may be used to evaluate for local spread into adjacent structures (t4 disease) and to diagnose distant metastases (m1). endoscopic ultrasonography (eus) is the modality of choice for distinguishing t1 tumors from higher stage lesions and for detecting and sampling regional lymph nodes (n1 disease). positron emission to ...200818852079
assessment of demographics factors and clinical staging in patients submitted to salvage surgery for oropharyngeal squamous cell carcinoma.the usual management of upper aero digestive tract squamous cell carcinoma is surgery associated or not to post surgical radiotherapy. loco-regional relapses constitute the main failure of the initial treatment and early diagnosis justifies the indication of salvage surgery.200818852978
assessment of clinical and therapeutic factors in patients with nasopharyngeal undifferentiated carcinoma.the nasopharyngeal carcinoma (npc) is a rare cancer with a high incidence in southern asia.200818852983
pathologic upstaging after laparoscopic radical nephrectomy.accurate tumor staging in renal cancer is critical for prognostic projections, follow-up schedules, clinical trials and potential systemic therapies. we studied patients undergoing laparoscopic radical nephrectomy (lrn) to determine the extent of upstaging on histopathology evaluation and correlated the clinical and pathology staging to determine the factors responsible for upstaging.200818937590
volume determination of oral cavity tumors by 3-dimensional ultrasonography.with the help of 3-dimensional (3d) ultrasound, the ultrasonographic determination of tumor volumes offers a new view of tumors in the oral cavity. these are classified according to their maximal diameter in tnm classification whereby the possibility exists in the high t category of overestimating small tumors that have spread into surrounding structures, and in the low t of underestimating large volume tumors that do not extend into surrounding structures.200818940495
thyroid hormone resistance.thyroid hormone resistance (thr) is a rare syndrome of reduced end organ sensitivity. patients with thr have elevated serum free thyroxine (ft4), free triiodothyronine (ft3), but normal or slightly elevated serum thyrotropin values. the characteristic clinical feature is goitre without symptoms and metabolic consequences of thyroid hormone excess. thr can be classified on the basis of tissue resistance into pituitary, peripheral or generalised (both pituitary and peripheral) types. mutations in ...200818940949
results of primary surgery with t4 non-small cell lung cancer during a 25-year period in a single center: the benefit is worth the risk.the purpose of this study was to assess operative mortality, morbidity, and long-term results of patients with surgically resected t4 non-small cell lung carcinoma.200818805134
the impact of lymph node station on survival in 348 patients with surgically resected malignant pleural mesothelioma: implications for revision of the american joint committee on cancer staging system.the propensity of malignant pleural mesothelioma to metastasize to n1 or n2 nodes and their corresponding prognostic value is unclear. the american joint committee on cancer staging system groups n1 and n2 disease together as stage iii. the goal of this study was to define the prognostic value of specific nodal stations.200818805259
effect of dena induced hepatocarcinogenesis on neuroendocrine levels in male rats.hepatocarcinogenesis was induced in sprague dawley rats by injecting diethylnitrosamine (dena); 150 mg/kg body weight, ip, a well known liver carcinogen and a mutagenic agent. concurrent with the induction of hepatocarcinoma, psychological stress was also elicited from the changes in brain neurotransmitters. noradrenaline and dopamine, the neurotransmitters of sympathetic system were estimated from the whole brain and corresponding hormones t3, t4 and prolactin were estimated from the blood of s ...200818807752
influence of correction objectives on the optimal scoliosis instrumentation strategy: a preliminary study.in three recent studies we have shown how different correction objectives from a group of experienced spine surgeons add to the variability in ais instrumentation strategies. this study examined the effect of correction objectives of three surgeons on the optimal instrumentation strategy. an optimization method using six instrumentation design parameters (e.g. limits of the instrumented segment, number, type and location of implants and rod shape) that were manipulated in a uniform experimental ...200818810011
comparison of the kyphosis angle evaluated by video rasterstereography (vrs) with x-ray measurements.surface topography evaluations are prone to technical errors due to postural sway of the patients measured. the technical error of lateral deviation (rms) and surface rotation (rms) may vary between 15 and 20%, while the kyphosis angle (ip-itl) has a technical error of only 5% (2,5 degrees), which is comparable to the x-ray measurement. purpose of this study was to investigate the hypothesis that video rasterstereography can be used for prognostication of a kyphosis patient.200818810015
basal cell carcinoma of the nose: an australian and new zealand radiation oncology patterns-of-practice study.patients with a basal cell carcinoma (bcc) of the nose may be recommended radiotherapy (rt) with a wide variation in techniques and prescribed dose fractionation schedules between clinicians. the aim of this study was to ascertain variability in the patterns of practice among australian and new zealand radiation oncologists (ros) when treating bcc arising on the nose. a postal survey was sent to 222 practising anz ros detailing 12 different clinical scenarios of a bcc arising on the nose. the tr ...200818811764
thyroid autoimmunity in patients with alopecia areata.alopecia areata (aa) is a common form of localized, non-scarring hair loss. it is characterized by the loss of hair in patches, total loss of scalp hair (alopecia totalis), or total loss of body hair (alopecia universalis). the etiopathogenesis of the disease is still unclear, but there is evidence that autoimmunity and endocrine dysfunction may be involved. the aim of this study was to determine whether aa is statistically associated with thyroid autoimmunity. in this retrospective epidemiologi ...200818812059
role of loops in the guanine quadruplex formation by dna/rna hybrid analogs of g4t4g4.cd spectroscopy, gel electrophoresis and absorption-based thermal stability were used to analyze quadruplex formation of rna and rna/dna hybrid analogs of the deoxyoligonucleotide g4t4g4, which forms a well-characterized basket-type quadruplex. all rna-containing dodecamers, g4u4g4, g4u4g4 and g4t4g4 (rna lower-case, dna capital letters), formed parallel, namely tetramolecular quadruplexes in na+-containing solutions. the u4 loop forced dna tetrads into the same conformation as adopted by g4u4g4 ...200818812187
effects of prenatal exposure to organochlorines on thyroid hormone status in newborns from two remote coastal regions in québec, canada.several prospective studies have revealed that prenatal exposure to polychlorinated biphenyls (pcbs) and other organochlorine compounds (ocs) affect neurodevelopment during infancy. one of the mechanisms by which pcbs might interfere with neurodevelopment is a deficit in thyroid hormone (th) concentrations.200818814871
the epidemiology of bladder cancer in russia.this study assessed the epidemiology of bladder cancer in russia. the available publications in russian were analysed, as well as information from the database of n. n. blokhin cancer research center, accumulating non-uniform data from different cities and regions of russia. in 2006 there were 68 129 patients with bladder cancer in russia, accounting for 2.8% of all cancer cases, with unknown proportions of males and females. in the same year 11 973 new bladder cancer cases were diagnosed, with ...200818815913
molecular alterations associated with bladder cancer initiation and progression.bladder cancer is the fifth most commonly diagnosed non-cutaneous solid malignancy, and the second most commonly diagnosed genitourinary malignancy amongst people living in the united states, where it is estimated that more than 61,000 new cases of bladder cancer will be diagnosed in the year 2008. approximately 90% of malignant tumors arising in the urinary bladder are of epithelial origin, the majority being transitional cell carcinomas. early stage bladder tumors have been classified into two ...200818815930
structural and thermodynamic characterization of t4 lysozyme mutants and the contribution of internal cavities to pressure denaturation.using small-angle x-ray scattering (saxs) and tryptophan fluorescence spectroscopy, we have identified multiple compact denatured states of a series of t4 lysozyme mutants that are stabilized by high pressures. recent studies imply that the mechanism of pressure denaturation is the penetration of water into the protein rather than the transfer of hydrophobic residues into water. to investigate water penetration and the volume change associated with pressure denaturation, we studied the solution ...200818816066
hepatocyte growth factor (hgf) and the satellite cell response following muscle lengthening contractions in humans.the time-courses of satellite cell (sc) activation and protein expression of hepatocyte growth factor (hgf), hgf activator (hgfa), hgfa inhibitor-1 (hai-1), and hgfa inhibitor-2 (hai-2) in human skeletal muscle, as well as serum hgf following a single bout of muscle lengthening contractions, were determined. eight recreationally active participants were recruited for the study. subjects performed 300 lengthening contractions involving the quadriceps femoris muscles of a single leg at a fixed vel ...200818816607
effect of silymarin on metabolic factors of food-restricted over conditioned wistar rats.this study was conducted to evaluate the changes in serum metabolic factors of over conditioned pregnant rats treated with silymarin in food restriction condition. sixty pregnant wistar rats were divided into five equal groups. all rats received high energy diet before treatments. control group were fed ad libitum (non-fr). rats in other groups received 50% of the food intake of non-fr group and served as food-restricted (fr) groups. three of five fr groups received 150, 200 and 400 mg kg(-1) si ...200818817226
an analysis on quality, colour, tissue texture, total soluble solid content, titratable acidity and ph of santol fruits (sandoricum koetjape burm. f.) merr. pui fai cultivar, grown in northern thailand.this laboratory experiment was carried out at the department of agricultural technology, mahasarakham university, northeast thailand during june to october 2007. the experiment aimed to search for the most appropriate harvesting age of fruits of santol orchard plants with respect to colour, tissue texture, total soluble solid content, titratable acidity and ph of santol fruits. a randomised complete block design (rcbd) with four replications was used. each replication consisted of 10 fruits, thu ...200818817267
total synthesis of (+)-cassaine via transannular diels-alder reaction.a full account of the total synthesis of (+)-cassaine ( 1) using the transannular diels-alder (tada) reaction as the pivotal construction is described. the strategy began from evans' oxazolidine 8, the only chiral source used for the total stereochemical outcome of the target molecule. the key intermediate 3 was obtained from 8 in 10 steps in 40% overall yield. following extensive optimization, the coupling of 3 on both ends with another densely functional partner 2 followed by tada reaction on ...200818817389
co-expression of igf-1 family members with myogenic regulatory factors following acute damaging muscle-lengthening contractions in humans.muscle regeneration following injury is dependent on the ability of muscle satellite cells to activate, proliferate and fuse with damaged fibres. this process is controlled by the myogenic regulatory factors (mrf). little is known about the temporal relation of the mrf with the expression of known myogenic growth factors (i.e. igf-1) in humans following muscle damage. eight subjects (20.6 +/- 2.1 years; 81.4 +/- 9.8 kg) performed 300 lengthening contractions (180 deg s(-1)) of their knee extenso ...200818818249
[apoptosis, proliferation and spleen histomorphometry of adult female rats with thyroid and ovarian hypofunction].apoptosis, proliferation and histomorphometry of spleen were investigated in ovariectomized and non-ovariectomized adult wistar rats maintained in hypothyroidism induced by daily administration of propylthiouracil (ptu) during 120 days. two groups ovariectomized euthyroid and non-ovariectomized euthyroid were used as controls. plasma was collected for free t4 dosage and the spleen for histomorphometry analysis, apoptosis index and the immunohistochemistry expression of caspase 3 and cdc47. value ...200818820815
regulation of the spovm gene of bacillus subtilis.the spovm gene of bacillus subtilis codes for a 26 amino-acid peptide that is essential for sporulation. analysis of the expression of the spovm gene revealed that wild-type cells started to synthesize a spovm-specific transcript at t2, whereas the spovm peptide accumulated at t4. both the transcript and the peptide were absent from an spovm knockout strain. the 5' untranslated region of the spovm transcript increased expression of spovm. possible regulation mechanisms are discussed.200818820968
determination of (+)-3,3',5,5'-tetraiodo-l-thyronine (l-t4) in serum and pharmaceutical formulations using a sequential injection analysis/immunosensor system.a sequential injection analysis/immunosensor system is proposed for the analysis of thyroxine (l-t4) in serum and in pharmaceutical formulations with a rate of 75 samples/hour. the immunosensor design is based on the physical immobilization of anti-l-t4 in carbon paste. the working concentration range of the immunosensor in the sequential injection analysis system is between 36 and 1080 ng/ml with a limit of detection of 24.6 ng/ml. the system is very reliable and very easy to design and operate ...200818821409
correlation between magnetic resonance imaging and histopathological tumor response after neoadjuvant chemotherapy in breast cancer.to evaluate the accuracy of magnetic resonance imaging in assessing tumor response following neoadjuvant chemotherapy in patients with locally advanced breast cancer.200818822682
[intervening and therapeutic effect of cordyceps mycelia extract on liver cirrhosis induced by dimethylnitrosamine in rats].to explore the intervening and therapeutic effect of cordyceps mycelia extract (cme) on liver cirrhosis induced by dimethylnitrosamine (dmn) in rats.200818822912
thoracic spinal cord compression by intramedullary hamartomatous tissue in a young boy: case report.spinal cord hamartomas are a rare occurrence characterized by well- differentiated mature elements located in an irregular position in the spinal cord.200818824961
resection line involvement after gastric cancer surgery: clinical outcome in nonsurgically retreated patients.resection line infiltration (rli) after surgical treatment represents an unfavorable prognostic factor in advanced gastric cancer. we performed a retrospective analysis of 89 patients with resection line involvement who did not undergo reoperation.200818825453
differential gene expression profiles of normal human parotid and submandibular glands.parotid and submandibular glands have different properties including characteristics of the secreted saliva and tumor incidences. the differences in properties of parotid and submandibular glands are not clear from a genetic viewpoint.200818826381
head and neck squamous cell carcinoma in 13 patients with fanconi anemia after hematopoietic stem cell transplantation.fanconi anemia (fa) is a chromosomal instability disorder with a very high risk of developing head and neck squamous cell carcinoma (hnscc), most notably after hematopoietic stem cell transplantation (hsct).200818831513
a novel thermophilic lysozyme from bacteriophage phiin93.the lysozyme of bacteriophage phiin93 was purified to apparent homogeneity with carboxymethyl sepharose and hydroxyapatie columns from lysates of the phage grown on thermus aquaticus tz2. the enzyme is a single polypeptide chain with a molecular weight of 33,000. from the determined n-terminal amio acids of the enzyme, the locus of the gene was specified on a phiin93 genome. the enzyme was not similar to egg white lysozyme, t4 phage lysozyme, or lambda phage lysozyme. the enzyme, phiin93 lysozym ...200818831965
squamous cell carcinoma of the buccal mucosa: a retrospective analysis of 22 cases.we examined our institution's experience with 22 cases of previously untreated buccal squamous cell carcinoma via a retrospective chart review. eleven of these patients had been treated with a combination of surgical excision and postoperative radiation therapy, 8 patients with surgical excision alone, and 3 patients with radiation therapy alone. the overall 3-year locoregional recurrence rate was 32% (n = 7). the 3-year survival rates were 82% after surgery plus radiation (9 of 11 patients), 63 ...200818833538
a pilot study on thoracoscopic internal mammary lymphatic chain dissection for breast cancer.to evaluate the feasibility of internal mammary lymphatic chain dissection by thoracoscopic surgery.200818835167
prognostic value of metabolic imaging in non-small cell lung cancers with neoplasic pleural effusion.the intensity of the [f]fluorodeoxyglucose (f-fdg) uptake is an independent prognostic indicator in non-small cell lung cancer (nsclc). we evaluate the relationship between the metabolic activity of the primary and the pleurisy in t4 nsclc.200818836376
[neoplasms of paranasal sinuses in material of ent department mss hospital in warsaw between 2006-2007].tumors of paranasal sinuses present a small percent of tumors detected in the region of head and neck 3-4% and they present a fraction of a percent of tumors in general /0.16%/. material: in the years 2004 and 2005, the national register of neoplasms recorded 120 and 132 cases of malignant tumors of paranasal sinuses, respectively. between 2006-2007 we treated 15 patients with tumors of paranasal sinuses underwent treatment at the ent department of the miedzyleski szpital specjalistyczny in wars ...200818837222
robot-assisted laparoscopic radical prostatectomy: perioperative outcomes of 1500 cases.robot-assisted laparoscopic radical prostatectomy (ralp) is an evolving minimally invasive treatment of for localized prostate cancer. we present our experience of 1500 consecutive cases with an analysis of perioperative outcomes.200818837657
early treatment with low fixed dose (5 mci) radioiodine therapy is effective in indian subjects with graves' disease.there is little consensus regarding the most appropriate dosage regimen for radioiodine treatment in graves' disease. the authors evaluated the efficacy of low fixed dose (5mci) of radioiodine therapy, in terms of its cure rate and promptness of control, as well possible factors influencing the outcome. one hundred and twenty five consecutive patients with graves' disease with persistent disease activity despite receiving carbimazole were treated with 5 mci fixed dose of i131. patients, who rema ...200818839646
a study on endocrine changes in patients in intensive care unit.pattern of endocrine changes in moderate to severely ill patients in a medical intensive care unit, correlation with the severity of illness and whether these changes can predict outcome of the critically ill patients were evaluated and studied in 80 patients admitted with acute physiology and chronic health evaluation (apache) ii score >10 and without any pre-existing endocrinopathies or on drugs likely to affect the endocrine axis. adrenal insufficiency was present in 45%, and mortality was hi ...200818839647
a multifactorial approach to the factors influencing determination of paravertebral depth.predicting the depth of needle insertion for paravertebral nerve blocks is currently based on patients' anthropometric characteristics, and the block level. although preliminary studies report relationships between paravertebral depth and the body mass index (bmi), the number of observations, to date, are inadequate to formulate reliable conclusions. this study was designed to determine which factors may predict the distance between the skin and paravertebral space, for patients undergoing parav ...200818840588
putative functional domains of human cytomegalovirus pul56 involved in dimerization and benzimidazole d-ribonucleoside activity.benzimidazole d-ribonucleosides inhibit dna packaging during human cytomegalovirus (hcmv) replication. although they have been shown to target pul56 and pul89 (the large and small subunits of the hcmv terminase, respectively) their mechanism of action is not yet fully understood. we aimed here to better understand hcmv dna maturation and the mechanism of action of benzimidazole derivatives.200818771048
intraoperative radioisotope injection for sentinel lymph node biopsy.preoperative injection of technetium-99 m sulfur colloid (tc-99) in the nuclear medicine department for localizing sentinel lymph nodes (slns) can be extremely painful for the patient. the difficulties in scheduling and the delay in starting surgery can be frustrating for the patient and the surgeon. we hypothesized that intraoperative injection facilitated by the subareolar technique would obviate the problems associated with preoperative injection.200818777194
label-free electrochemical monitoring of dna ligase activity.this study presents a simple, label-free electrochemical technique for the monitoring of dna ligase activity. dna ligases are enzymes that catalyze joining of breaks in the backbone of dna and are of significant scientific interest due to their essential nature in dna metabolism and their importance to a range of molecular biological methodologies. the electrochemical behavior of dna at mercury and some amalgam electrodes is strongly influenced by its backbone structure, allowing a perfect discr ...200818778033
use of experimental crystallographic phases to examine the hydration of polar and nonpolar cavities in t4 lysozyme.there is conflicting evidence as to whether cavities in proteins that are nonpolar and large enough to accommodate solvent are empty or are occupied by disordered water molecules. here, we use multiple-wavelength x-ray data collected from crystals of the selenomethionine-substituted l99a/m102l mutant of t4 lysozyme to obtain a high-resolution electron density map free of bias that is unavoidably associated with conventional model-based structure determination and refinement. the mutant, l99a/m10 ...200818780783
chemotherapy in addition to preoperative radiotherapy in locally advanced rectal cancer - a systematic overview.the value of chemotherapy with radiotherapy has been explored in recent randomised clinical trials in locally advanced rectal cancer (larc). an overview of these trials was made together with a discussion of what constitutes larc. although imaging is required for adequate staging of primary rectal cancer, the term 'locally' advanced has no consistent definition and has been used differently in the trials. three large randomised trials, however, in different subsets, show that radiochemotherapy ( ...200818782078
preoperative assessment of hilar cholangiocarcinoma by dual-modality pet/ct.the purpose of the current study was to evaluate the accuracy of (18)f-fdg pet/ct in staging hilar cholangiocarcinoma.200818767120
pre-operative chemoradiotherapy with uft and leucovorin in patients with advanced rectal cancer: a phase ii study.the aim this study was to determine the pathologic complete response (pcr) rate defined as tumor regression grade 1 (trg1) and toxicity profile of the combination of high-dose pre-operative radiotherapy and simultaneous uft/leucovorin (lv) in patients with locally advanced rectal cancer.200818768230
the serum levels of 17beta-estradiol, progesterone and triiodothyronine correlate with brown adipose tissue thermogenic parameters during aging.sex and thyroid hormones are among the factors modulating energy metabolism through regulation of mitochondrial oxidative capacity. brown adipose tissue (bat) in old female rats has been shown to maintain, better than males, the ability to produce heat when exposed to cold. considering the decline that takes place in gonadal and thyroid function during aging, the aim of this work was to test whether the age-related hormonal status may be a potential mediator of the gender differences in bat decl ...200818769061
modeling the nonthyroidal illness syndrome.to provide an update on the pathogenesis and significance of the nonthyroidal illness syndrome.200818769221
kinetics and thermodynamics of salt-dependent t7 gene 2.5 protein binding to single- and double-stranded dna.bacteriophage t7 gene 2.5 protein (gp2.5) is a single-stranded dna (ssdna)-binding protein that has essential roles in dna replication, recombination and repair. however, it differs from other ssdna-binding proteins by its weaker binding to ssdna and lack of cooperative ssdna binding. by studying the rate-dependent dna melting force in the presence of gp2.5 and its deletion mutant lacking 26 c-terminal residues, we probe the kinetics and thermodynamics of gp2.5 binding to ssdna and double-strand ...200818772224
the preparation of site-specifically modified riboswitch domains as an example for enzymatic ligation of chemically synthesized rna fragments.this protocol describes an efficient method for the preparation of riboswitch domains comprising up to approximately 200 nt containing site-specific nucleoside modifications. the strategy is based on enzymatic ligation of chemically synthesized rna fragments. the design of ligation sites strictly follows the criterion that all fragments comprise less than approximately 50 nt. this allows the researcher to rely on custom synthesis services and to utilize the large pool of commercially available, ...200818772873
translational bypassing without peptidyl-trna anticodon scanning of coding gap mrna.half the ribosomes translating the mrna for phage t4 gene 60 topoisomerase subunit bypass a 50 nucleotide coding gap between codons 46 and 47. the pairing of codon 46 with its cognate peptidyl-trna anticodon dissociates, and following mrna slippage, peptidyl-trna re-pairs to mrna at a matched triplet 5' adjacent to codon 47, where translation resumes. here, in studies with gene 60 cassettes, it is shown that the peptidyl-trna anticodon does not scan the intervening sequence for potential complem ...200818772887
construction of a photo-switchable gene for turning on and off gene expression with light irradiation.a photoresponsive gfp gene was constructed by attaching a t7 promoter that involves two azobenzene moieties as the photoswitch. the azobenzene moieties tethered on d-threoninol were inserted precisely into the sequence of t7 promoter at two positions in the nontemplate strand. by using azobenzene-tethered dna as one primer, azobenzene was attached to gfp gene after pcr amplification. however, a single-stranded overhang involving azobenzene was formed because primer extension stopped at the posit ...200818776232
revised phylogenetic relationships among herpesviruses isolated from sturgeons.initial phylogenetic comparisons based on a region of the dna polymerase of seven herpes-like viruses found in sturgeons in north america and europe indicated the presence of three distinct clades. a revised phylogenetic analysis of the same viruses, based on corrected dna polymerase sequences and newly obtained sequence data from the putative atp subunit of the terminase gene, indicate only two clades. these two clades correspond to the historical designations given to these herpes-like viruses ...200818783130
gene expression profiles associated with advanced pancreatic cancer.few studies have addressed the expression profiles associated with progression of pancreatic cancer to advanced disease. towards this end, we performed expression profiling of a series of normal pancreas, pancreatitis and cancer tissues representing early stage resected pancreatic cancers (stages pt2/t3), late stage unresectable cancers (stage pt4) and matched metastases to a variety of organ sites. microarray data was analyzed using linear modeling of microarray data (limma), and differentially ...200818784821
thyroxine treatment stimulated ovarian follicular angiogenesis in immature hypothyroid rats.the development of mature ovarian follicles is greatly dependent on healthy thecal angiogenesis. recent experimental evidence showed that thyroxine (t4) treatment promoted ovarian follicle development in immature hypothyroid (rdw) rats. however, an involvement of thyroid hormone in ovarian follicular angiogenesis has not yet been demonstrated. by morphological and molecular approaches, the present studies demonstrated that antral follicles in untreated, t4- or equine chorionic gonadotropin (ecg) ...200818785121
microbial levan in the diet of labeo rohita hamilton juveniles: effect on non-specific immunity and histopathological changes after challenge with aeromonas hydrophila.a 60-day feeding trial was conducted to study the immuno-protective effect of microbial levan on labeo rohita juveniles challenged with aeromonas hydrophila. six purified diets were prepared with different levels of microbial levan: control (no levan), t1 (basal + 0.25%), t2 (basal + 0.50%), t3 (basal + 0.75%), t4 (basal + 1%) and t5 (basal + 1.25%), fed to six groups of fish in triplicate. among the treatment groups the haemoglobin content and total leucocyte count were increased with a dietary ...200818786027
melanoma in organ transplant recipients: clinicopathological features and outcome in 100 cases.organ transplant recipients have a higher incidence of melanoma compared to the general population but the prognosis of this potentially fatal skin cancer in this group of patients has not yet been established. to address this, we undertook a multicenter retrospective analysis to assess outcome for 100 melanomas (91 posttransplant and 9 pretransplant) in 95 individuals. data were collected in 14 specialist transplant dermatology clinics across europe belonging to the skin care in organ transplan ...200818786232
clinical inquiries: which lab tests are best when you suspect hypothyroidism?thyroid-stimulating hormone (tsh) level is the preferred test for initial evaluation of suspected primary hypothyroidism (strength of recommendation [sor]: expert opinion). if tsh is abnormal, a free thyroxine (t4) level will further narrow the diagnosis. obtain a triiodothyronine (t3) level if tsh is undetectable and free t4 is normal. when assessing the adequacy of replacement therapy in primary hypothyroidism, the tsh is the most important parameter to monitor (sor: expert opinion). because t ...200818786337
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