Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| stability indicating validated hplc method for quantification of levothyroxine with eight degradation peaks in the presence of excipients. | a simple, sensitive, accurate, and robust stability indicating analytical method is presented for identification, separation, and quantitation of l-thyroxine and eight degradation impurities with an internal standard. the method was used in the presence of commonly used formulation excipients such as butylated hydroxyanisole, povidone, crospovidone, croscarmellose sodium, mannitol, sucrose, acacia, lactose monohydrate, confectionary sugar, microcrystalline cellulose, sodium laurel sulfate, magne ... | 2008 | 18524511 |
| a proteomic approach to the identification of the major virion structural proteins of the marine cyanomyovirus s-pm2. | in this study, an ms-based proteomics approach to characterizing the virion structural proteins of the novel marine 'photosynthetic' phage s-pm2 is presented. the virus infects ecologically important cyanobacteria of the genus synechococcus that make a substantial contribution to primary production in the oceans. the s-pm2 genome encodes 236 orfs, some of which exhibit similarity to known phage virion structural proteins, but the majority (54%) show no detectable homology to known proteins from ... | 2008 | 18524932 |
| attenuation of lower-thoracic, lumbar, and sacral spinal cord motion: implications for imaging human spinal cord structure and function. | recent literature indicates that cervical and upper-thoracic spinal cord motion adversely affect both structural and functional mr imaging (fmri; particularly diffusion tensor imaging [dti] and spinal fmri), ultimately reducing the reliability of these methods for both research and clinical applications. in the present study, we investigated motion of the lower-thoracic, lumbar, and sacral cord segments to evaluate the incidence of similar motion-related confounds in these regions. | 2008 | 18524976 |
| thyroid function, alzheimer's disease and postoperative cognitive dysfunction: a tale of dangerous liaisons? | hypothyroidism and hyperthyroidism are commonly present conditions in adults, leading to neurological symptoms, affecting the central and peripheral nervous system, and to neurocognitive impairment. several studies investigated a possible association between alzheimer's disease (ad) and thyroid dysfunctions. increasing evidence supports an extensive interrelationship between thyroid hormones and the cholinergic system, which is selectively and early affected in ad. moreover, thyroid hormones neg ... | 2008 | 18525131 |
| treatment of base of tongue cancer with paclitaxel, ifosfamide, and cisplatinum induction chemotherapy followed by chemoradiotherapy. | to assess the efficacy of paclitaxel, ifosfamide, and cisplatinum induction chemotherapy plus concurrent chemoradiation in the treatment of stage iii and iv base of tongue cancer. | 2008 | 18528311 |
| value of bronchoscopy after eus in the preoperative assessment of patients with esophageal cancer at or above the carina. | esophageal cancer is an aggressive disease with a strong tendency to infiltrate into surrounding structures. the aim of the present study is to determine the additional value of bronchoscopy for detecting invasion of the tracheobronchial tree after endoscopic ultrasonography (eus) in the preoperative assessment of patients with esophageal cancer at or above the carina. | 2008 | 18528732 |
| plasma thyroxine and cortisol profiles and gill and kidney na+/k+-atpase and sdh activities during acclimation of the catfish heteropneustes fossilis (bloch) to higher salinity, with special reference to the effects of exogenous cortisol on hypo-osmoregulatory ability of the catfish. | when the stenohaline catfish heteropneustes fossilis was transferred from fresh water (fw) to 30% seawater (sw), the na(+)/k(+)-atpase activity significantly increased in the kidney, while in gills it remained more or less constant. a reverse pattern was observed for succinic dehydrogenase (sdh) activity inasmuch as it significantly increased in gills and remained unchanged in the kidney. plasma osmolality significantly increased within 3 days of transfer to 30% sw and remained significantly hig ... | 2008 | 18533747 |
| incidence of iodine deficiency in turkish patients with congenital hypothyroidism. | turkey is located in an area of mild to moderate iodine deficiency. the aim of the present study was to investigate the incidence of iodine deficiency in patients with congenital hypothyroidism. | 2008 | 18533935 |
| foldon-guided self-assembly of ultra-stable protein fibers. | a common objective in protein engineering is the enhancement of the thermodynamic properties of recombinant proteins for possible applications in nanobiotechnology. the performance of proteins can be improved by the rational design of chimeras that contain structural elements with the desired properties, thus resulting in a more effective exploitation of protein folds designed by nature. in this paper, we report the design and characterization of an ultra-stable self-refolding protein fiber, whi ... | 2008 | 18535304 |
| [influence of humic acid fertilizer on biomass accumulation and quality of angelica sinensis]. | to study the influence of humic acid fertilizer on plant growth, assimilation base, dried biomass accumulation, yield, quality and disease infection of angelica sinensis. | 2008 | 18536458 |
| hyperplastic goitre and mortality in captive-reared black stilts ( himantopus novaezelandiae ). | to study the gross, histopathological and clinico-pathological findings in cases of hyperplastic goitre in sub-adult captive- reared black stilts following their release on riverbeds in the south canterbury region of new zealand. | 2008 | 18536773 |
| congenital hypothyroidism. | congenital hypothyroidism (ch) is one of the most common preventable causes of mental retardation with a worldwide incidence of 1:4000 live births. ideally universal screening at 3-4 days of age should be done for detecting ch. abnormal values on screening (t4 < 6.5 ug/dl, tsh > 20 micro/l) should be confirmed by a venous sample (using age appropriate cutoffs) before initiating treatment. term as well as preterm infants with low t4 and elevated tsh should be started on l-thyroxine at a dose of 1 ... | 2008 | 18536892 |
| intraoperative radiotherapy combined with adjuvant chemoradiotherapy for locally advanced gastric adenocarcinoma. | to evaluate the efficacy of intraoperative radiotherapy (iort) followed by concurrent chemotherapy and external beam rt (ebrt) in the treatment of locally advanced gastric adenocarcinoma. | 2008 | 18538489 |
| quality of life after sentinel lymph node biopsy or axillary lymph node dissection in stage i/ii breast cancer patients: a prospective longitudinal study. | breast cancer patients' quality of life (qol) after surgery has been reported to improve significantly over time. little is known about qol recovery after sentinel lymph node biopsy (slnb) in comparison to axillary lymph node dissection (alnd). | 2008 | 18597146 |
| a novel therapeutic paradigm to treat congenital hypothyroidism. | to determine the effectiveness of a novel therapeutic paradigm to treat congenital hypothyroidism (ch) incorporating variable initial doses of l-t4 based on the underlying aetiology and frequent monitoring, up to 2 years of age. | 2008 | 18598275 |
| decrease of evoked delta, theta and alpha coherences in alzheimer patients during a visual oddball paradigm. | in this study event related coherence of patients with alzheimer type of dementia (ad) was analyzed by using a visual oddball paradigm as stimuli. a total of 21 mild probable ad subjects (10 untreated, 11 treated) were compared with a group of 19 healthy controls. the members of the groups had their eeg recorded from 12 electrodes by means of a visual oddball paradigm. the evoked coherence was analyzed for delta (1-3.5 hz), theta (4-7 hz) and alpha (8-13 hz) frequency ranges for inter-hemispheri ... | 2008 | 18598686 |
| preventive wrapping of the fragile tracheobronchial wall using a flap of latissimus dorsi muscle during esophagectomy after chemoradiotherapy. | thanks to significant recent progress in the application of chemoradiotherapy (crt) in the treatment of esophageal cancer, the numbers of operations on patients who have undergone preoperative crt are increasing. in these patients, preoperative crt often leads to formation of an unstable, scleroid layer comprised of what appears to be scar tissue around the tracheobronchial wall. this scleroid layer must be removed with the tumor, thereby weakening the wall. | 2008 | 18600026 |
| neurodevelopmental and neurophysiological actions of thyroid hormone. | for over 100 years, thyroid hormones have been known to be essential for neonatal neurodevelopment but whether they are required by the foetal brain remains a matter of controversy. for decades, the prevailing view was that thyroid hormones are not necessary until after birth because circulating levels in the foetus are very low and the placenta forms an efficient barrier to their transfer from the mother. clinical observations of good neurological outcome following early treatment of congenital ... | 2008 | 18601701 |
| prognostic factors for lymph node metastasis from advanced squamous cell carcinoma of the skin of the trunk and extremities. | squamous cell carcinoma (scc) of the skin of the trunk and extremities may present lymph node metastasis with difficult disease control and poor survival. the purpose of this study was to identify risk factors for lymph node metastasis and outcome. | 2008 | 18601735 |
| infertility in the cycling queen: seven cases. | in this study we examined seven queens with normal oestrous cycles and a history of infertility after normal matings. we performed clinical examination, vaginal cytology, evaluation of oestradiol, progesterone and total t4 levels, vaginal bacterial culture, ultrasonography, and serum analyses for detection of antibodies against chlamydia and feline leukaemia virus (felv) antigenemia. ovariohysterectomy (ohe) was recommended for 1/7 queens because of pathological uterine changes detected at ultra ... | 2008 | 18602323 |
| allan-herndon-dudley syndrome. | allan-herndon-dudley syndrome (ahds) is a rare x-linked disorder caused by mutation in the gene encoding the monocarboxylate transporter-8. abnormal transport function is reflected by elevated free t3 and decreased free t4 levels along with clinical features characterized by neurological abnormalities including global developmental delay, central hypotonia, rotatory nystagmus, impaired hearing, spasticity and contractures of joints. we report a child with classical clinical features along with c ... | 2008 | 18589880 |
| variable region of betanodavirus rna2 is sufficient to determine host specificity. | betanodaviruses, the causative agents of viral nervous necrosis in marine fish, have bipartite positive-sense rna genomes. the viruses have been classified into 4 distinct types based on nucleotide sequence similarities in the variable region (the so-called t4 region) of the smaller genomic segment rna2 (1.4 kb). betanodaviruses have marked host specificity, although the primary structures of the viral rnas and encoded proteins are similar among the viruses. we have previously demonstrated, usin ... | 2008 | 18589996 |
| [determining the thyroid hormones t3 and t4 in the urine: an unreliable test for hypothyroidism]. | 2008 | 18590068 | |
| posterior midline approach for single-stage en bloc resection and circumferential spinal stabilization for locally advanced pancoast tumors. technical note. | the treatment of pancoast (superior sulcus) tumors that extensively invade the vertebral column remains controversial. different surgical approaches involving multistage resection techniques have been previously described for superior sulcus tumors that invade the chest wall and spinal column. typically a posterior approach to stabilize the spine is followed by a second-stage thoracotomy (posterolateral or trap door) for definitive en bloc resection of stage t4 pancoast tumors. the authors repor ... | 2008 | 18590415 |
| maternal thyroid hypofunction and pregnancy outcome. | to estimate whether maternal thyroid hypofunction is associated with complications. | 2008 | 18591312 |
| potassium perchlorate only temporarily restores euthyroidism in patients with amiodarone-induced hypothyroidism who continue amiodarone therapy. | amiodarone-induced hypothyroidism (aih) may occur in patients with or without underlying thyroid disorders. in the latter, restoration of euthyroidism, after amiodarone discontinuation, can be facilitated and accelerated by a short course of potassium perchlorate (kclo4). however, it is unknown whether kclo4 may exert similar effects on thyroid function of aih patients if amiodarone treatment is continued. | 2008 | 18591883 |
| commentary: discordant measurements of serum triiodothyronine (t4), thyroxine (t3) and thyroid-stimulating hormone (tsh). | 2008 | 18593966 | |
| tissue factor expression in non-small cell lung cancer: relationship with vascular endothelial growth factor expression, microvascular density, and k-ras mutation. | tissue factor (tf) is the physiological trigger of blood coagulation, but it could also have an important role in cancer by regulating vegf expression and angiogenesis. | 2008 | 18594312 |
| biomechanical contribution of transverse connectors to segmental stability following long segment instrumentation with thoracic pedicle screws. | an in vitro biomechanical cadaver study of long segment thoracic pedicle screw constructs with transverse connectors (tc). | 2008 | 18594445 |
| variability in thyroid-stimulating hormone suppression by human chorionic [corrected] gonadotropin during early pregnancy. | the objective of the study was to further explore relationships between human chorionic gonadotropin (hcg), tsh, and free t4 in pregnant women at 11 through 18 wk gestation. | 2008 | 18544616 |
| [effect of pinggan qianyang on hypothalamic proteome in the hyperthyroid rats with hyperactivity of liver-yang]. | to investigate the effect of pinggan-qianyang (pgqy), a chinese medicine, on hypothalamic proteome in the hyperthyroid rats with hyperactivity of liver-yang, and to explore its mechanism. | 2008 | 18544841 |
| effects of the height of ball-backrest on head and shoulder posture and trunk muscle activity in vdt workers. | this study was designed to elucidate the effects of a ball-backrest at different heights on the head and shoulder posture and neck and trunk muscles of visual display terminal (vdt) workers who adopted a forward head posture when working at a vdt. twenty-three vdt workers with forward head posture performed the keyboard typing work at a vdt without and with a ball-backrest at the l3, t10, and t4 levels. surface electromyograms were recorded from the neck, shoulder, and trunk muscles, and the for ... | 2008 | 18544890 |
| radiotherapy as primary treatment modality. | the proper management of prostate cancer is dependent on appropriate risk categorization, based on pretreatment prostate-specific antigen (psa), clinical stage and gleason score (gs). the use of radiotherapy in low-risk (t1-t2a, psa < 10 ng/ml and gs <or= 6) and intermediate-risk (t1/t2, psa < 20 ng/ml and gs <or= 7) disease is well established, with comparable results to surgery in the era of modern radiation therapy. however, cancer-related outcomes in some radiotherapy patients might still be ... | 2008 | 18544981 |
| [effect of exogenous thyroxin on renal ion-regulating and acid-secreting functions in white rats]. | experimental hyperthyreosis was stimulated by intraventricular injections of sodium solithyroxin (t4) suspension on 1% starch gel during 10 days at a dose of 10 microg/100 g of body mass (n = 15) or 20 microg/100 g of body mass (n = 15). renal function was tested by 5 % water loading after 24 hrs. since the last t4 injection. urine and blood plasma samples were analyzed for creatinine; in addition, urine was analyzed for sodium and potassium ions of titrated acids, ammonium cations, and ph. thyr ... | 2008 | 18564575 |
| modulation of t4 gene 32 protein dna binding activity by the recombination mediator protein uvsy. | bacteriophage t4 uvsy is a recombination mediator protein that promotes assembly of the uvsx-ssdna presynaptic filament. uvsy helps uvsx to displace t4 gene 32 protein (gp32) from ssdna, a reaction necessary for proper formation of the presynaptic filament. here we use dna stretching to examine uvsy interactions with single dna molecules in the presence and absence of gp32 and a gp32 c-terminal truncation (*i), and show that in both cases uvsy is able to destabilize gp32-ssdna interactions. in t ... | 2008 | 18565541 |
| thyroid hormone transport and metabolism by organic anion transporter 1c1 and consequences of genetic variation. | organic anion transporting polypeptide (oatp) 1c1 has been characterized as a specific thyroid hormone transporter. based on its expression in capillaries in different brain regions, oatp1c1 is thought to play a key role in transporting thyroid hormone across the blood-brain barrier. for this reason, we studied the specificity of iodothyronine transport by oatp1c1 in detail by analysis of thyroid hormone uptake in oatp1c1-transfected cos1 cells. furthermore, we examined whether oatp1c1 is rate l ... | 2008 | 18566113 |
| the success rate of i-131 ablation in differentiated thyroid cancer: comparison of uptake-related and fixed-dose strategies. | the aim of the study was to compare the success rate of an uptake-related ablation protocol in which the dose depends on an i-131 24-h neck uptake measurement and a fixed-dose ablation protocol in which the dose depends on tumour stage. | 2008 | 18567668 |
| treatment of patients with clinically lymph node-negative squamous cell carcinoma of the oral cavity. | to evaluate treatment outcome and to determine optimal treatment strategy for patients with clinically lymph node-negative (n0) oral cavity squamous cell carcinoma (scc). | 2008 | 18573849 |
| sentinel node concept in clinically n0 laryngeal and hypopharyngeal cancer. | sentinel nodes (sns) are the lymph nodes that directly receive lymphatic flow from a primary cancer lesion. the sn concept implies that lymphatic metastasis initially occurs at sns. sn navigation surgery can be introduced for cancers in which the sn concept is established. in sn navigation surgery, lymph node dissection beyond sns can be omitted if sns are metastasis free. although the sn concept has been investigated frequently for oral and oropharyngeal cancer, it has so far been investigated ... | 2008 | 18574637 |
| analysis of the k-ras/b-raf/erk signal cascade, p53 and cmap as markers for tumor progression in colorectal cancer patients. | colorectal cancer patients may succumb to their disease because of local recurrence or formation of metastasis. to develop a prognostic tool for these fatal types of progression, 23 patients with colorectal carcinoma were included in this study for the detection at the time of surgery of the incidence of k-ras, b-raf and p53 mutations, the phosphorylation status of erk and the expression of cystatin-like metastasis-associated protein (cmap) in tumor, mucosa and liver samples. polymerase chain re ... | 2008 | 18575712 |
| potential energy surfaces for all-trans p5h6(+) and p5me6(+) may be less complicated than anticipated. | burford and co-workers recently (2007) investigated the synthesis, structure, and pseudorotation of a family of cyclotetraphosphinophosphonium ions comprehensively. we now report theoretical computations through the ccsd(t) level to study the conformations of the parent model rings, p5h6(+) and p5me6(+). the all-trans conformations on the full pseudorotational cycle for the cyclotetraphosphinophosphonium cation (p5h6(+)) and for its methyl-substituted derivative (p5me6(+)) were located systemati ... | 2008 | 18576644 |
| the odyssey of nontoxic nodular goiter (ntng) in greece under suppression therapy, and after improvement of iodine deficiency. | nontoxic nodular goiter (ntng) is common in endemic goiter regions. thyroxine (t4) is often used to treat ntng. there is little information regarding t4 treatment in regions that have recently become iodine sufficient. we studied the effect of t4 treatment on thyroid function tests in southwestern greece (swg), a recently iodine-sufficient area. | 2008 | 18578614 |
| efficacy of contact lens systems against recent clinical and tap water acanthamoeba isolates. | a recent increase in acanthamoeba keratitis (ak) cases has been associated with complete moistureplus, although many cases used other solutions. complete moistureplus contains taurine and hydroxypropyl methylcellulose, unlike other multipurpose solutions (mpss). the purpose of this study is to (1) determine contact lens solution efficacy against recent clinical and tap water acanthamoeba isolates and (2) determine whether taurine inclusion increases acanthamoeba survival against contact lens sol ... | 2008 | 18580265 |
| [surgical results of t4 lung cancer invading left atrium and great vessels]. | to analyzed the indication and prognostic factors of surgical treatment of lung cancer invading left atrium and great vessels (t4). | 2008 | 18581890 |
| mechanism of trifluralin-induced thyroid tumors in rats. | trifluralin, an herbicide, has been reported to cause a significant increase in thyroid follicular cell tumors in male fischer 344 rats. this study was designed to determine the mechanism of thyroid hyperactivity after trifluralin exposure. a group of 15 male fischer 344 rats were exposed to trifluralin-fortified (6500 ppm) diet for 2 weeks. the time weighted average daily intake of trifluralin was 441+/-77 mg/kg/day. ten rats of the group were sacrificed and the sera analyzed for t3, t4, and ts ... | 2008 | 18582544 |
| multiple segmental and selective isotope labeling of large rna for nmr structural studies. | multiple segmental and selective isotope labeling of rna with three segments has been demonstrated by introducing an rna segment, selectively labeled with (13)c(9)/(15)n(2)/(2)h((1', 3', 4', 5', 5''))-labeled uridine residues, into the central position of the 20 kda epsilon-rna of duck hepatitis b virus. the rna molecules were produced via two efficient protocols: a two-step protocol, which uses t4 dna ligase and t4 rna ligase 1, and a one-pot protocol, which uses t4 rna ligase 1 alone. with t4 ... | 2008 | 18583361 |
| carbaryl, 1-naphthol and 2-naphthol inhibit the beta-1 thyroid hormone receptor-mediated transcription in vitro. | effects of pesticides on the function of thyroid have attracted lots of attention because thyroid hormones (ths) play a major role in mammalian brain development. in order to screen for compounds that acted on the thyroid hormone receptor (tr) signaling pathway, we transiently transfected the vector pgal4-l-trbeta1 (gal4 dbd fused to htrbeta1 lbd) and gal4-responsive luciferase reporter puas-tk-luc into hepg2 cell, developing a reporter gene assay which showed good response to triiodothyronine ( ... | 2008 | 18584933 |
| rna-templated single-base mutation detection based on t4 dna ligase and reverse molecular beacon. | a novel rna-templated single-base mutation detection method based on t4 dna ligase and reverse molecular beacon (rmb) has been developed and successfully applied to identification of single-base mutation in codon 273 of the p53 gene. the discrimination was carried out using allele-specific primers, which flanked the variable position in the target rna and was ligated using t4 dna ligase only when the primers perfectly matched the rna template. the allele-specific primers also carried complementa ... | 2008 | 18585229 |
| first- and second-trimester thyroid hormone reference data in pregnant women: a faster (first- and second-trimester evaluation of risk for aneuploidy) research consortium study. | the purpose of this study was to calculate first and second trimester reference ranges and within-woman correlations for tsh, free t4, and thyroid antibodies. | 2008 | 18585522 |
| vertebral fracture assessment in healthy men: prevalence and risk factors. | vertebral fracture assessment (vfa) is a technology that can reliably and accurately diagnose vertebral fractures with greater patient convenience, less radiation exposure, and lower cost than standard spine radiography. | 2008 | 18585994 |
| modulation of the packaging reaction of bacteriophage t4 terminase by dna structure. | bacteriophage terminases package dna through the portal ring of a procapsid during phage maturation. we have probed the mechanism of the phage t4 large terminase subunit gp17 by analyzing linear dnas that are translocated in vitro. duplex dnas of random sequence from 20 to 500 bp were efficiently packaged. dye and short, single-stranded end extensions were tolerated, whereas 20-base extensions, hairpin ends, 20-bp dna-rna hybrid, and 4-kb dsrna substrates were not packaged. molecules 60 bp long ... | 2008 | 18586272 |
| acupuncture treatment of dysmenorrhea resistant to conventional medical treatment. | we evaluated the effect of acupuncture on nsaid resistant dysmenorrhea related pain [measured according to visual analogue scale (vas)] in 15 consecutive patients. pain was measured at baseline (t1), mid treatment (t2), end of treatment (t3) and 3 (t4) and 6 months (t5) after the end of treatment. substantial reduction of pain and nsaid assumption was observed in 13 of 15 patients (87%). pain intensity was significantly reduced with respect to baseline (average vas = 8.5), by 64, 72, 60 or 53% a ... | 2008 | 18604253 |
| apobec3g and apobec3f require an endogenous cofactor to block hiv-1 replication. | apobec3g (a3g)/apobec3f (a3f) are two members of apobec3 cytidine deaminase subfamily. although they potently inhibit the replication of vif-deficient hiv-1, this mechanism is still poorly understood. initially, a3g/a3f were thought to catalyze c-to-u transitions on the minus-strand viral cdnas during reverse transcription to disrupt the viral life cycle. recently, it was found more likely that a3g/a3f directly interrupts viral reverse transcription or integration. in addition, a3g/a3f are both ... | 2008 | 18604271 |
| [neonatal screening program for congenital hypothyroidism in northeast of brazil: criteria, diagnosis and results]. | it was evaluated the concentration of tsh in blood spot (tshneo) of 48,039 children included in the neonatal screening program (nsp) for congenital hypothyroidism (ch) of sergipe (se), a state in the northeast of brazil. it was also evaluated the concentration of serum tsh, total t4 and free t4 in the recalled children suspicious of having ch, their age in several phases of the program, the covering and frequency of the nsp in the cases from january 2005 to august 2006, comparing them with liter ... | 2008 | 18604374 |
| electronic properties of star-shaped oligofluorenes containing an isotruxene core: interplay of para and ortho conjugation effects in phenylene-based pi systems. | the synthesis, photophysics, cyclic voltammetry, spectroelectrochemistry, and electrogenerated chemiluminescence (ecl) properties of a series of unsymmetrical star-shaped oligophenylenes it1-it4 are reported. the electronic couplings among the three oligofluorene arms in it1-it4 are strong due to the para-ortho branched isotruxene core. the ortho conjugation effect results in band splitting in the absorption spectra for both the neutral and the radical ionic form with a stronger effect for the l ... | 2008 | 18605684 |
| a rapid and sensitive chemiluminescent immunoassay of total thyroxin with dmae x nhs-labeled. | a novel chemiluminescence immunoassay (clia) of total thyroxin (tt4) with the acridinium ester of dmae x nhs [2',6'-dimethyl-4'-(n-succinimidyloxycarbonyl) phenyl-10-methyl-acridinium-9-carboxylate methosulfate] labeled has been developed. in our method, microwells were coated with anti-t4 monoclonal antibody (mcab) and dmae x nhs synthesized by our laboratory was conjugated with streptavidin (sa). t4-bsa was conjugated with biotin-n-hydroxysuccinimide (b x nhs), t4-bsa- b x nhs and the t4 in th ... | 2008 | 18569374 |
| evaluation of prostate cancer characteristics in four populations worldwide. | prostate cancer is common around the world, but rates of advanced disease differ substantially by race and geography. although a major health issue, little is known about prostate cancer presentation in west africa and india compared to the united states (us). | 2008 | 18570709 |
| ultrasound appearance of thyroid tissue in hypothyroid infants. | to identify those infants who need a higher starting dose of levothyroxine (l-t4) for early normalization of thyroid-stimulating hormone (tsh) level. | 2008 | 18571545 |
| [adjuvant chemotherapy followed by conformal chemoradiotherapy in gastric carcinoma]. | analysis of the feasibility and results of adjuvant chemotherapy followed by conformal chemoradiotherapy after surgery for gastric carcinoma. | 2008 | 18571967 |
| convergent mechanisms of genome evolution of large and giant dna viruses. | we have taken advantage of the availability of the genome sequences of a collection of large and giant viruses infecting bacteria (t4 family) and eukaryotes (ncldv group) to assess some of the evolutionary forces which might have shaped their genomes. despite having apparently different ancestors, these two groups of viruses are affected by convergent evolutionary forces. both types of virus probably originated from a simple and ancient viral ancestor with a small subset of 30-35 genes encoding ... | 2008 | 18572389 |
| the genotypic characterisation of acanthamoeba isolates from human ocular samples. | we characterised 37 amoebae cultured from corneal scrapings, contact lenses or lens case solutions of patients with suspected acanthamoeba keratitis. | 2008 | 18586902 |
| surgery alone for squamous cell carcinoma of the oral cavity: survival rates, recurrence patterns, and salvage treatment. | surgery alone may be a reliable and feasible treatment of choice in selected patients with squamous cell carcinoma (scc) of the oral cavity, given the proper indications. | 2008 | 18607922 |
| how good is endoscopic ultrasound for tnm staging of gastric cancers? a meta-analysis and systematic review. | to evaluate the accuracy of endoscopic ultrasound (eus) for staging of gastric cancers. | 2008 | 18609685 |
| hormone affinity and fibril formation of piscine transthyretin: the role of the n-terminal. | transthyretin (ttr) transports thyroid hormones (ths), thyroxine (t4) and triiodothyronine (t3) in the blood of vertebrates. th-binding sites are highly conserved in vertebrate ttr, however, piscine ttr has a longer n-terminus which is thought to influence th-binding affinity and may influence ttr stability. we produced recombinant wild type sea bream ttr (sbttrwt) plus two mutants in which 6 (sbttrm6) and 12 (sbttrm12) n-terminal residues were removed. ligand-binding studies revealed similar af ... | 2008 | 18620020 |
| spinal cord compression by a solitary metastasis from a low grade leydig cell tumour: a case report and review of the literature. | leydig tumour is rare and there are only three cases with metastatic disease reported. | 2008 | 18616814 |
| genetic loci linked to pituitary-thyroid axis set points: a genome-wide scan of a large twin cohort. | previous studies have shown that circulating concentrations of tsh, free t4, and free t3 are genetically regulated, but the genes responsible remain largely unknown. the aim of this study was to identify genetic loci associated with these parameters. | 2008 | 18611976 |
| identifying and genotyping transgene integration loci. | the random germline integration of genetically engineered transgenes has been a powerful technique to study the role of particular genes in variety of biological processes. although the identification of the transgene insertion site is often not essential for functional analysis of the transgene, identifying the site can have practical benefit. enabling one to distinguish between animals that are homozygous or hemizygous for the transgene locus could facilitate breeding strategies to produce ani ... | 2008 | 18612840 |
| an animal model to study health effects during continuous low-dose exposure to the nerve agent vx. | in the present study, we have developed an animal model to study long-term health effects of continuous exposure of toxic chemical agents, in awake, freely moving rats. the aim was to evaluate the effect of low-dose exposure of the nerve agent vx, and to find specific biomarkers for intoxication. to exclude the influence of stress, we used an implanted radio-telemetric device for online registration of physiological parameters, and an osmotic pump, implanted subcutaneously, for continuous exposu ... | 2008 | 18614271 |
| a modern regimen of pre-operative concurrent chemo-radiation therapy in locally advanced rectal cancer. | to evaluate the efficacy and toxicity of preoperative concurrent capecitabine and radiotherapy in the treatment of resectable locally advanced rectal cancer (larc). | 2008 | 18615536 |
| definitive radiation therapy for squamous cell carcinoma of the soft palate. | we report the university of florida experience with soft-palate carcinoma treated with radiotherapy alone or combined with adjuvant chemotherapy and/or neck dissection for residual disease in the neck. | 2008 | 18615732 |
| the role of proteases in the differentiation of acanthamoeba castellanii. | proteases are significant determinants of protozoan pathogenicity and cytolysis of host cells. however, there is now growing evidence of their involvement in cellular differentiation. acanthamoeba castellanii of the t4 genotype elaborates a number of proteases, which are inhibited by the serine protease inhibitor phenylmethylsulphonyl fluoride. using this and other selective protease inhibitors, in tandem with sirna primers, specific to the catalytic site of acanthamoeba serine proteases, we dem ... | 2008 | 18616591 |
| [the effect of long-term external ionizing radiation on the functional activity of rat thyroid under enhanced potassium iodide consumption]. | the study was devoted to the effect of long-term (20 days) external ionizing radiation at a dose of 0.5 gy on the iodide metabolism in the rat thyroid under supplementation of high iodine doses (10 daily ki doses). it was found that the potassium iodide administration partially prevented the effects of a post radiation decrease of serum thyroid hormone levels (the level of t4 was normal and that of t3 was 77.4% of the controls). after the supplementation of 10 daily iodide doses, the rat thyroid ... | 2008 | 18666583 |
| [quality of life among patients with advanced prostate cancer: a survey using functional assessment of cancer therapy-prostate in china]. | to assess the quality of life of patients with advanced prostate cancer in china and compare the influences of different stage and different forms of therapy. | 2008 | 18642765 |
| combining infrared and low-temperature asymptotes in yang-mills theories. | we demonstrate that the powerlike nonperturbative behavior of gluon and ghost propagators in the infrared limit of yang-mills theories can provide at finite temperatures t a negative t4 contribution to the pressure and energy density. the existence of a mass gap then implies new relations between the infrared critical exponents of gluon and ghost propagators. | 2008 | 18643416 |
| subdomain competition, cooperativity, and topological frustration in the folding of chey. | the folding of multidomain proteins often proceeds in a hierarchical fashion with individual domains folding independent of one another. a large single-domain protein, however, can consist of multiple modules whose folding may be autonomous or interdependent in ways that are unclear. we used coarse-grained simulations to explore the folding landscape of the two-subdomain bacterial response regulator chey. thermodynamic and kinetic characterization shows the landscape to be highly analogous to th ... | 2008 | 18644380 |
| trends in the operative management and outcomes of t4 lung cancer. | this study describes temporal trends and variables in the operative management and outcomes of patients with t4 lung tumors in the general community. | 2008 | 18640298 |
| relationship between pulmonary emphysema and osteoporosis assessed by ct in patients with copd. | osteoporosis is one of the important systemic features of copd. although copd itself is regarded as one risk factor for osteoporosis, the relationship between the extent of emphysema and reduced bone density is still unclear. our first aim was therefore to measure vertebral bone density and the percentage of low-attenuation area (laa%) in the lungs using chest ct scans in copd patients. our second aim was to investigate the relationships among ct scan measurements, anthropometric parameters, and ... | 2008 | 18641115 |
| prognostic relevance of centromere protein h expression in esophageal carcinoma. | many kinetochore proteins have been shown to be associated with human cancers. the aim of the present study was to clarify the expression of centromere protein h (cenp-h), one of the fundamental components of the human active kinetochore, in esophageal carcinoma and its correlation with clinicopathological features. | 2008 | 18700042 |
| [a case of advanced gastric cancer successfully treated with s-1 and paclitaxel followed by curative resection]. | a 59-year-old man diagnosed with stage iv advanced gastric cancer due to pancreatic invasion(t4)and splenic hilum lymph node metastasis(n3)was initially treated with neoadjuvant chemotherapy using s-1 and cddp. however, it was discontinued because the tumor marker increased after 1 course. instead of s-1 and cddp, s-1 and paclitaxel were then administered. after 4 courses, ct scan revealed reduced tumor size and the disappearance of splenic hilum lymph node swelling that indicated pr of the chem ... | 2008 | 18701853 |
| redor nmr characterization of dna packaging in bacteriophage t4. | bacteriophage t4 is a large-tailed escherichia coli virus whose capsid is 120x86 nm. atp-driven dna packaging of the t4 capsid results in the loading of a 171-kb genome in less than 5 min during viral infection. we have isolated 50-mg quantities of uniform (15)n- and [epsilon-(15)n]lysine-labeled bacteriophage t4. we have also introduced (15)nh(4)(+) into filled, unlabeled capsids from synthetic medium by exchange. we have examined lyo- and cryoprotected lyophilized t4 using (15)n{(31)p} and (31 ... | 2008 | 18703073 |
| nmo-igg positive neuromyelitis optica in a patient with myasthenia gravis but no thymectomy. | here we report on a 44-year old woman presenting with both myasthenia gravis (mg) and neuromyelitis optica (nmo). mri showed transverse myelitis extending from c2 to t4, multifocal demyelinating lesions in the supratentorial white matter, and left optic neuritis. serological analysis demonstrated antibodies to acetylcholine receptors as well as nmo-igg. to our knowledge, this is the first case of nmo-igg positive nmo in a patient with mg but no history of thymectomy or immunosuppression. | 2008 | 18703206 |
| d2 lymphadenectomy alone or with para-aortic nodal dissection for gastric cancer. | gastrectomy with d2 lymphadenectomy is the standard treatment for curable gastric cancer in eastern asia. whether the addition of para-aortic nodal dissection (pand) to d2 lymphadenectomy for stage t2, t3, or t4 tumors improves survival is controversial. we conducted a randomized, controlled trial at 24 hospitals in japan to compare d2 lymphadenectomy alone with d2 lymphadenectomy plus pand in patients undergoing gastrectomy for curable gastric cancer. | 2008 | 18669424 |
| randomized phase iii study comparing preoperative radiotherapy with chemoradiotherapy in nonresectable rectal cancer. | preoperative chemoradiotherapy is considered standard treatment for locally advanced rectal cancer, although the scientific evidence for the chemotherapy addition is limited. this trial investigated whether chemotherapy as part of a multidisciplinary treatment approach would improve downstaging, survival, and relapse rate. | 2008 | 18669453 |
| hypothyroidism protects di(n-butyl) phthalate-induced reproductive organs damage in sprague-dawley male rats. | this study examined the deleterious effects of di(n-butyl) phthalate (dbp) on the male reproductive organs in hypothyroid rats. hypothyroidism was induced in prepubertal male rats (28 days of age) by an intraperitonial (i.p.) injection of 10 mg/kg/day propylthiouracil (ptu) for 30 days. dbp (100 and 500 mg/kg/day) was administered by oral gavages to the intact or hypothyroid rats for 30 days. the body weight of the ptu-treated rats was significantly lower than the control group. the total triiod ... | 2008 | 18670161 |
| multiple atp binding is required to stabilize the "activated" (clamp open) clamp loader of the t4 dna replication complex. | most dna replication systems include a sliding clamp that encircles the genomic dna and links the polymerase to the template to control polymerase processivity. a loading complex is required to open the clamp and place it onto the dna. in phage t4 this complex consists of a trimeric clamp of gp45 subunits and a pentameric loader assembly of four gp44 and one gp62 subunit(s), with clamp loading driven by atp binding. we measure this binding as a function of input ligand concentration and show tha ... | 2008 | 18676368 |
| outcomes of adjuvant chemoradiotherapy after a radical gastrectomy and a d2 node dissection for gastric adenocarcinoma. | intergroup 0116 (int-0116) established adjuvant chemoradiation as the standard of care for resected high-risk adenocarcinoma of the stomach in the united states. however, adjuvant chemoradiation remains controversial in many parts of asia and europe, where patients tend to undergo a more thorough d2 dissection. in int-0116, 90% of patients had a limited or inadequate node dissection (d0 or d1). also, 17% of patients in the chemoradiation arm had to discontinue treatment because of toxicities. th ... | 2008 | 18677137 |
| stability of hard tissue profile after mandibular setback in sagittal split osteotomies: a longitudinal and long-term follow-up study. | the aim of the study was to conduct a long-term follow-up on the stability of the hard tissues after bilateral sagittal split osteotomy (bsso) with rigid internal fixation (rif)to set back the mandible and to compare it with that of mandibular advancement performed by the same team of surgeons and with the same examination protocol. seventeen consecutive patients (6 females and 11 males) could be re-examined 12.7 years (t5) after surgery. the previous examinations were before surgery (t1), 5 day ... | 2008 | 18678756 |
| stapled closed technique for laryngectomy and pharyngeal repair. | total laryngectomy is a recognised treatment for advanced laryngeal carcinoma. traditionally, pharyngeal repair is performed with layered sutures. we describe our experience with a technique of closed pharyngoplasty using a linear stapler device. | 2008 | 18680636 |
| thyroid testing in sloughis. | thyroid hormone concentrations were found to be different in greyhounds and whippets compared with nonsight hound dogs. | 2008 | 18681922 |
| [usefulness of bilateral sympathectomy using video-assisted thorascopic surgery in the treatment of essential hyperhidrosis]. | essential, idiopathic, or primary hyperhidrosis is defined as excessive sweating in certain areas of the body due to factors unrelated to other disease. clinical presentation can be categorized as palmar, plantar, axillary, or craniofacial. medical treatment (aluminium salts, iontophoresis, anticholinergic drugs, and alpha2-agonists) is of questionable effectiveness. intradermal injections of botulinum toxin are very effective for the treatment of axillary hyperhidrosis. surgical treatment invol ... | 2008 | 18682164 |
| deiodinase-mediated thyroid hormone inactivation minimizes thyroid hormone signaling in the early development of fetal skeleton. | thyroid hormone (th) plays a key role on post-natal bone development and metabolism, while its relevance during fetal bone development is uncertain. to study this, pregnant mice were made hypothyroid and fetuses harvested at embryonic days (e) 12.5, 14.5, 16.5 and 18.5. despite a marked reduction in fetal tissue concentration of both t4 and t3, bone development, as assessed at the distal epiphyseal growth plate of the femur and vertebra, was largely preserved up to e16.5. only at e18.5, the hypo ... | 2008 | 18682303 |
| reversal of cadmium-induced thyroid dysfunction by selenium, zinc, or their combination in rat. | the aim of this study was to evaluate the potential benefit of combined treatment with zinc (zn) and selenium (se) in reversing cadmium (cd)-induced thyroid dysfunction compared to se or zn treatment alone in rats exposed to cd. for this purpose, 30 adult male wistar albino rats were equally divided into control and four treated groups receiving either 200 ppm cd (as cdcl2), 200 ppm cd + 500 ppm zn (as zncl2), 200 ppm cd + 0.1 ppm se (as na2seo3), or 200 ppm cd + 500 ppm zn + 0.1 ppm se in their ... | 2008 | 18685812 |
| on the importance of selenium and iodine metabolism for thyroid hormone biosynthesis and human health. | the trace elements iodine and selenium (se) are essential for thyroid gland functioning and thyroid hormone biosynthesis and metabolism. while iodine is needed as the eponymous constituent of the two major thyroid hormones triiodo-l-thyronine (t3), and tetraiodo-l-thyronine (t4), se is essential for the biosynthesis and function of a small number of selenocysteine (sec)-containing selenoproteins implicated in thyroid hormone metabolism and gland function. the se-dependent iodothyronine deiodinas ... | 2008 | 18686295 |
| event related oscillations in euthymic patients with bipolar disorder. | bipolar disorder involves dysfunction in gamma amino butyric acid (gaba)/glutamatergic systems and neural circuits that regulate cognitive processing. valproate, a mood stabilizing anticonvulsant, modulates gaba/glutamate and shows neuroprotective effect. electroencephalographic oscillatory activity assessment is an alternative brain imaging technique with high time resolution. it presents integrative brain functioning. we aimed to assess the oscillatory responses of patients with bipolar disord ... | 2008 | 18687385 |
| double-strand dna cleavage by copper complexes of 2,2'-dipyridyl with guanidinium/ammonium pendants. | two ligands with guanidinium/ammonium groups were synthesized and their copper complexes, [cu(l1)cl2](clo4)2.h2o (1) and [cu(l2)cl2](clo4)2 (2) (l1 = 5,5'-di[1-(guanidyl)methyl]-2,2'-bipyridyl cation and l2 = 5,5'-di[1-(amino)methyl]-2,2'-bipyridyl cation), were prepared to serve as nuclease mimics. x-ray analysis revealed that cu(ii) ion in 1 has a planar square cun2cl2-configuration. the shortest distance between the nitrogen of guanidinium and copper atoms is 6.5408(5) a, which is coincident ... | 2008 | 18688419 |
| overexpression of a secretory leukocyte protease inhibitor in human gastric cancer. | complementary dna microarrays have identified aberrantly expressed genes in patients with gastric cancer. one that encodes secretory leukocyte protease inhibitor (slpi) is among the aberrantly expressed genes and is associated with metastasis in gastric cancers. we evaluated the potential of slpi expression as a helpful biomarker for detection of gastric cancer. tumor tissue and matching noncancerous mucosa were obtained from 60 patients immediately after gastric resection. slpi expression level ... | 2008 | 18688858 |
| primary hypothyroidism in a child simulating a prolactin-secreting adenoma. | to report a case of primary hypothyroidism associated to hyperprolactinemia mimicking a prolactin secreting adenoma. | 2008 | 18690463 |
| [continuous subarachnoid analgesia and anesthesia for labor and cesarean section in a patient who had previously undergone surgery for ependymoma]. | we report the case of a 38-year-old primipara who had undergone surgery 2 years earlier for an intradural ependymoma at l2-l3 and who was currently asymptomatic. a combined epidural-subarachnoid block was performed for analgesia during labor but this technique was only effective for the first 2 hours. when analgesia via epidural cannula was no longer adequate, it was decided to perform a continuous subarachnoid block. later, the fetus's head was seen to be too large to fit through the pelvis; fo ... | 2008 | 18693664 |
| refractory headaches due to multilevel thoracic cerebrospinal fluid leaks. | spontaneous cerebrospinal fluid leak is a well-documented cause of postural headache. we report a medically refractory headache due to multilevel thoracic cerebrospinal fluid leaks. | 2008 | 18694451 |
| lc3, an autophagosome marker, is highly expressed in gastrointestinal cancers. | autophagy is a bulk protein and organelle degradation process essential for cell maintenance and viability. microtubule-associated protein 1 light chain 3 (lc3), the mammalian homologue of yeast atg8, is involved in autophagosome formation during autophagy. the aim of this study was to investigate lc3 expression in gastrointestinal cancers to elucidate the role of autophagy in human cancer development. we evaluated lc3 expression by immunohistochemistry in 163 gastrointestinal cancers including ... | 2008 | 18695874 |