Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| t-even-related bacteriophages as candidates for treatment of escherichia coli urinary tract infections. | multidrug-resistant uropathogenic escherichia coli (upec) is increasing gradually on a worldwide scale. we therefore examined the possibility of bacteriophage (phage) therapy for urinary tract infections (utis) caused by the upec strains as an alternative to chemotherapy. in addition to the well-known t4 phage, kep10, which was newly isolated, was used as a therapeutic phage candidate. kep10 showed a broader bacteriolytic spectrum (67%) for upec strains than t4 (14%). morphological and genetic a ... | 2008 | 18188500 |
| esophageal cancer. a prospective phase ii study of concomitant-boost external-beam chemoradiation with a top-up endoluminal boost. | to present the results of a prospective phase ii study in esophageal carcinoma. | 2008 | 18188518 |
| assessment of stroke volume index with three different bioimpedance algorithms: lack of agreement compared to thermodilution. | the accuracy of bioimpedance stroke volume index (svi) is questionable as studies report inconsistent results. it remains unclear whether the algorithms alone are responsible for these findings. we analyzed the raw impedance data with three algorithms and compared bioimpedance svi to transpulmonary thermodilution (svi(td)). | 2008 | 18188539 |
| clinical significance of nuclear factor (nf)-kappab levels in urothelial carcinoma of the urinary bladder. | nuclear factor (nf)-kappab has been reported to be constitutively activated in various human neoplasms. however, its clinical significance in bladder urothelial carcinoma (uc) remains an unresolved issue. we conducted this study trying to elucidate the role of nfkappab in bladder uc and its potential prognostic significance, by quantifying immunohistochemically the levels of p65/rela expression in paraffin-embedded tissue from 116 patients. some of the cases had previously been stained for cellu ... | 2008 | 18188593 |
| crystal structure of a novel bacterial cell-surface flagellin binding to a polysaccharide. | bacterial flagellins are generally self-assembled into extracellular flagella for cell motility. however, the flagellin homologue p5 is found on the cell surface of sphingomonas sp. a1 (strain a1) and binds tightly to the alginate polysaccharide. to assimilate alginate, strain a1 forms a mouthlike pit on the cell surface and concentrates the polymer in the pit. p5 is a candidate receptor that recognizes extracellular alginate and controls pit formation. to improve our understanding of the struct ... | 2008 | 18189419 |
| thyroid function testing in elephant seals in health and disease. | northern elephant seal skin disease (nessd) is a severe, ulcerative, skin condition of unknown cause affecting primarily yearling northern elephant seals (mirounga angustirostris); it has been associated with decreased levels of circulating thyroxine (t4) and triiodothyronine (t3). abnormalities of the thyroid gland that result in decreased hormone levels (hypothyroidism) can result in hair loss, scaling and secondary skin infections. however, concurrent illness (including skin ailments) can sup ... | 2008 | 18190914 |
| effects of adult dysthyroidism on the morphology of hippocampal neurons. | this study investigates the effect of thyroid hormones on the morphology of hippocampal neurons in adult rats. hypo- and hyperthyroidism were induced by adding 0.02% methimazole and 1% l-thyroxine, in drinking water from 40 days of age, respectively. when the rats were 89 days old their brains were removed and stained by a modified golgi method and blood samples were collected in order to measure t4 serum levels. neurons were selected and drawn using a camera lucida. our results show that methim ... | 2008 | 18190975 |
| european eel (anguilla anguilla l.) metallothionein, endocrine, metabolic and genotoxic responses to copper exposure. | this study investigated anguilla anguilla (european eel) physiological and genotoxic responses to copper (cu) and their relation with metallothionein (mt) protection. eels were exposed during 7 days to cu 0.2 micromol/l. mt induction was assessed in gill and liver, revealing significant response only in liver. endocrine responses displayed a plasma free triiodothyronine (t3) and cortisol significant decrease, though the thyroid-stimulating hormone (tsh) and free thyroxine (t4) concentrations wer ... | 2008 | 18192012 |
| diffusion-weighted mri in cervical cancer. | the purpose was to investigate the potential value of apparent diffusion coefficient (adc) measurement with mri in the assessment of cervix cancer. diffusion-weighted mri was performed in 47 patients with cervical carcinoma undergoing chemoradiation therapy and 26 normal controls on a 1.5-t system with a b-value of 600 s/mm(2). figo stage, tumor volume, nodal status, interstitial fluid pressure (ifp) and oxygen measurements were recorded. response was defined as no visible tumor 3-6 months follo ... | 2008 | 18193428 |
| intra-arterial chemoradiation for t3-4 oral cavity cancer: treatment outcomes in comparison to oropharyngeal and hypopharyngeal carcinoma. | surgery followed by radiotherapy is the standard of care for resectable locally advanced oral cavity squamous cell carcinoma (scc). we report the treatment outcomes of patients with t3-t4 scc of the oral cavity treated with chemoradiation, an alternative approach. | 2008 | 18194553 |
| morphological and functional changes in the thyroid gland of methyl thiophanate-injected lizards, podarcis sicula. | the thyroid has been shown to be a target organ for environmental chemicals, specifically endocrine-disrupting contaminants. reptiles are particularly suitable as contaminant biomonitors due to their persistence in a variety of habitats, wide geographic distribution, longevity, and, in many cases, site fidelity. methyl thiophanate is a systemic broad-spectrum fungicide used to prevent and control plant diseases caused by various fungi. the aim of this study was to develop an integrated biologica ... | 2008 | 18196192 |
| on the origin of the polar order of t4 lysozyme on planar model surfaces. | site directed spin labeling is used to investigate the origin of the macroscopic alignment of t4 lysozyme vectorially tethered to planar biomimetic surfaces. t4 lysozyme was adsorbed to a quartz-supported dioleoylphosphatidylcholine (dopc) bilayer by selective binding of the histidine-tagged protein to functionalized headgroups (1,2-dioleoyl-sn-glycero-3-[[n(5-amino-1-carboxypentyl)iminodiacetic acid]succinyl], dogs nta) of the bilayer. this results in a polar oriented ensemble of proteins on th ... | 2008 | 18171040 |
| thyroxine increases the rate but does not alter the pattern of innervation during embryonic chick corneal development. | embryonic chick corneal nerves reach limbal mesenchyme by embryonic day (e)5, encircle the cornea in several days, then defasciculate into the stroma simultaneously from all sides, while extracellular keratan sulfate proteoglycan (kspg) accumulates from posterior to anterior stroma. precocious thyroxine (t4)-induced increases in corneal thinning/transparency are blocked by 2-thiouracil (2-tu) inhibition of t3 synthesis. the hypothesis for this study was that precocious t4 exposure increases corn ... | 2008 | 18172086 |
| effectiveness of x-ray and computed tomography screening for assessing pulmonary involvement in patients with head and neck squamous cell carcinoma. | to evaluate the benefits of chest computed tomography and x-ray as screening tools in patients with newly diagnosed head and neck squamous cell carcinoma, to determine the incidence of lung metastases or synchronous pulmonary lesions, and to evaluate factors associated with positive radiological findings. | 2008 | 18177532 |
| squamous cell carcinoma of the temporal bone. | the aim of this study was to present the management and survival data of patients with squamous cell carcinoma of the temporal bone, and to discuss whether extensive surgery improves survival. | 2008 | 18177533 |
| 1-deoxyrubralactone, a novel specific inhibitor of families x and y of eukaryotic dna polymerases from a fungal strain derived from sea algae. | talaroflavone (1) and 1-deoxyrubralactone (2) are natural compounds isolated from cultures of a fungal strain derived from sea algae, and their structures were determined by spectroscopic analyses. compound 2 is a novel rubralactone derivative, 6-hydroxy-8-methoxy-1-methyl-1,2,3a,9b-tetrahydrocyclopenta[c]isochromene-3,5-dione. these compounds selectively inhibited the activities of families x and y of eukaryotic dna polymerases (pols), and compound 2 was a stronger inhibitor than compound 1. th ... | 2008 | 18178092 |
| serotypes a1 and a2 of mannheimia haemolytica are susceptible to genotypic, capsular and phenotypic variations in contrast to t3 and t4 serotypes of bibersteinia (pasteurella) trehalosi. | mannheimia haemolytica and bibersteinia (pasteurella) trehalosi are the most common bacterial isolates that cause pulmonary diseases in ruminants worldwide. the disease is determined by specific serotypes found in cattle and small ruminants. the molecular epidemiology of strains involved in disease is important in the control of outbreaks as well as in the preparation of vaccines. this study aimed to detect the instability and variations of bacterial strains that may affect the analysis of epide ... | 2008 | 18179587 |
| changes in oral health-related quality of life during fixed orthodontic appliance therapy. | our objective was to determine changes in oral health-related quality of life (ohrqol) during fixed orthodontic appliance therapy. | 2008 | 18174067 |
| tsh alone is not sufficient to exclude all patients with a functioning thyroid nodule from undergoing testing to exclude thyroid cancer. | the purpose of the study was to analyze whether the thyroid-stimulating hormone (tsh) alone avoids tests to exclude malignancy in all patients with functional thyroid nodules (ftn). | 2008 | 18175114 |
| the diagnostic value of 124i-pet in patients with differentiated thyroid cancer. | the purpose of this prospective study was to evaluate the clinical diagnostic value of iodine-124 (124i)-positron emission tomography (pet) in patients with advanced differentiated thyroid carcinoma (dtc) and to compare the 124i-pet imaging results with the 131i whole-body scan (wbs). | 2008 | 18175115 |
| a family with a novel tsh receptor activating germline mutation (p.ala485val). | autosomal dominant nonautoimmune hyperthyroidism (adnah) is caused by gain of function mutations in the tsh receptor (tshr) gene and characterized by toxic thyroid hyperplasia with a variable age of onset in the absence of thyroid antibodies and clinical symptoms of autoimmune thyroid disease in at least two generations. we report here a turkish family with a novel tshr gene mutation with distinct features all consistent with adnah. thyroid function tests of the proband were as follows: free t3: ... | 2008 | 18175146 |
| adenocarcinoma of ethmoid: a gettec retrospective multicenter study of 418 cases. | to determine risk factors and evaluate the treatment of ethmoid adenocarcinoma. epidemiologic data were recorded and compared with the literature. | 2008 | 18176354 |
| comparison of the clinical and pathological features between patients with recurrent metastatic breast carcinoma and patients with initially metastatic breast carcinoma. | to compare initial metastatic breast carcinoma (mbc) with recurrent mbc and assess their biologic phenotypes and clinical behaviors. | 2008 | 18176678 |
| prognostic significance of depth of invasion, vascular invasion and numbers of lymph node retrievals in combination for patients with stage ii colorectal cancer undergoing radical resection. | to determine which aspects of tumor histology influenced the postoperative relapse and overall survival rates after radical resection of uicc stage ii colorectal cancer (crc). | 2008 | 18163435 |
| vertebral body growth after craniospinal irradiation. | to estimate the effects of radiotherapy and clinical factors on vertebral growth in patients with medulloblastoma and supratentorial primitive neuroectodermal tumors treated with craniospinal irradiation (csi) and chemotherapy. | 2008 | 18164830 |
| excellent local control with stereotactic radiotherapy boost after external beam radiotherapy in patients with nasopharyngeal carcinoma. | to determine long-term outcomes in patients receiving stereotactic radiotherapy (srt) as a boost after external beam radiotherapy (ebrt) for locally advanced nasopharyngeal carcinoma (npc). | 2008 | 18164839 |
| phase i-ii trial of concurrent capecitabine and oxaliplatin with preoperative intensity-modulated radiotherapy in patients with locally advanced rectal cancer. | to identify the maximal tolerated dose level of preoperative intensity-modulated radiotherapy combined with capecitabine and oxaliplatin and to evaluate the efficacy. | 2008 | 18164861 |
| implementation of a t4 extraction control for molecular assays of cerebrospinal fluid and stool specimens. | the use of appropriate extraction and amplification controls for acellular specimens is not standardized in the clinical laboratory community. extraction controls and checks for inhibitors of amplification in cellular specimens are most often accomplished by amplification of an internal human genomic target. this approach is not feasible for acellular specimens, which may contain little or no amplifiable genomic material. other specimen types, such as stool, frequently contain amplification inhi ... | 2008 | 18165271 |
| the therapeutic potential of intraoperative hypercapnia during video-assisted thoracoscopy in pediatric patients. | although the cardiovascular effect of co2 insufflation has not been reported in pediatric thoracoscopy, several clinical trials have demonstrated significant hemodynamic deterioration in adults. we investigated the concept of therapeutic hypercapnia for counteracting the hemodynamic effect of induced capnothorax. | 2008 | 18165558 |
| bacteriophages support anti-tumor response initiated by dc-based vaccine against murine transplantable colon carcinoma. | bacteriophages in eukaryotic hosts may behave as particulate antigens able to activate the innate immune system and generate adaptive immunity. dendritic cells (dcs) play a key role in the initiation of the immune response, mainly by priming t cell-mediated immunity. for this reason, they are increasingly applied as an adjuvant for effective anti-tumor therapies in animal models as well as in a few clinical trials. the presented study focused on the application of mouse dcs which were activated ... | 2008 | 18166233 |
| post-thyroidectomy thyroxine replacement dose in patients with or without compensated heart failure: the role of cytokines. | to investigate the potential association between serum inflammatory cytokine levels and post-thyroidectomy thyroxine replacement dose in patients with or without compensated heart failure. | 2008 | 18166485 |
| tsh-receptor autoimmunity in graves' disease after therapy with anti-thyroid drugs, surgery, or radioiodine: a 5-year prospective randomized study. | autoimmunity against the tsh receptor is a key pathogenic element in graves' disease. the autoimmune aberration may be modified by therapy of the hyperthyroidism. | 2008 | 18166819 |
| changes in heart rate variability and qt dispersion in patients with overt hypothyroidism. | the aim of the present study was to evaluate the effect of clinical hypothyroidism on cardiovascular autonomic function and ventricular repolarization. | 2008 | 18166821 |
| quantifying protein microstructure and electrostatic effects on the change in gibbs free energy of binding in immobilized metal affinity chromatography. | electrostatic forces play a major role in maintaining both structural and functional properties of proteins. a major component of protein electrostatics is the interactions between the charged or titratable amino acid residues (e.g., glu, lys, and his), whose pk(a) (or the change of the pk(a)) value could be used to study protein electrostatics. here, we report the study of electrostatic forces through experiments using a well-controlled model protein (t4 lysozyme) and its variants. we generated ... | 2008 | 18229947 |
| spinal cord transection modifies ileal fluid and electrolyte transport in rats. | spinal cord injury (sci) is associated with severe autonomic changes, including inhibition of gastrointestinal (gi) motility. gi motility changes are known to affect electrolytes transport and these changes have not been adequately studied after sci. we studied the ileal permeability to fluid and electrolytes in rats submitted to experimental spinal cord transection (sct), between t4 and t5, throughout the first week after sct. sct increased ileal secretion of na+ (p<0.05) and decreased the cl(- ... | 2008 | 18230418 |
| serum tsh and serum thyroid peroxidase antibody fluctuate in parallel and high urinary iodine excretion predicts subsequent thyroid failure in a 1-year study of patients with untreated subclinical hypothyroidism. | to explore the possibility of predicting decline or improvement in thyroid function over 1 year, and to investigate the correlations of serum tsh (s-tsh) with hypothyroidism-related symptoms and signs, serum thyroid peroxidase antibody (s-tpo-ab) and urinary iodine excretion in individual patients with untreated subclinical hypothyroidism (sh). | 2008 | 18230828 |
| influence of probiotic and conventional yoghurt on the status of vitamins b1, b2 and b6 in young healthy women. | in vitro studies indicate that yoghurt bacteria are able to generate several water-soluble vitamins and therefore yoghurt could be a good source of these micronutrients. however, whether lactobacilli or other viable bacteria release the synthesized vitamins or utilize vitamins from their surroundings is a matter of debate. this study was carried out to investigate whether probiotic and traditional yoghurt bacteria are able to influence the status of different b vitamins (b(1), b(2), b(6)) in you ... | 2008 | 18230968 |
| molecular characterization and expression analysis of five different elongation factor 1 alpha genes in the flatfish senegalese sole (solea senegalensis kaup): differential gene expression and thyroid hormones dependence during metamorphosis. | eukaryotic elongation factor 1 alpha (eef1a) is one of the four subunits composing eukaryotic translation elongation factor 1. it catalyzes the binding of aminoacyl-trna to the a-site of the ribosome in a gtp-dependent manner during protein synthesis, although it also seems to play a role in other non-translational processes. currently, little information is still available about its expression profile and regulation during flatfish metamorphosis. with regard to this, senegalese sole (solea sene ... | 2008 | 18234081 |
| the atpase domain of the large terminase protein, gp17, from bacteriophage t4 binds dna: implications to the dna packaging mechanism. | translocation of double-stranded dna into a preformed capsid by tailed bacteriophages is driven by powerful motors assembled at the special portal vertex. the motor is thought to drive processive cycles of dna binding, movement, and release to package the viral genome. in phage t4, there is evidence that the large terminase protein, gene product 17 (gp17), assembles into a multisubunit motor and translocates dna by an inchworm mechanism. gp17 consists of two domains; an n-terminal atpase domain ... | 2008 | 18234214 |
| p16ink4 immunoreactivity is a reliable marker for urothelial carcinoma in situ. | morphological discrimination of urothelial carcinoma (uc) in situ, a precursor of high-grade invasive carcinoma, from severe reactive atypia is essential, but can be challenging at times. mutations of the cell cycle regulatory gene ink4a (located at 9p21) that encodes p16(ink4) are one of the critical early events in carcinogenesis of uc. the purpose of this study was to investigate p16(ink4) expression in different urothelial lesions and assess its possible utility in distinguishing reactive ve ... | 2008 | 18234280 |
| simulation of nitroxide electron paramagnetic resonance spectra from brownian trajectories and molecular dynamics simulations. | a simulated continuous wave electron paramagnetic resonance spectrum of a nitroxide spin label can be obtained from the fourier transform of a free induction decay. it has been previously shown that the free induction decay can be calculated by solving the time-dependent stochastic liouville equation for a set of brownian trajectories defining the rotational dynamics of the label. in this work, a quaternion-based monte carlo algorithm has been developed to generate brownian trajectories describi ... | 2008 | 18234808 |
| phase ii trial of preoperative chemoradiotherapy followed by surgical resection in patients with superior sulcus non-small-cell lung cancers: report of japan clinical oncology group trial 9806. | to evaluate the safety and efficacy of preoperative chemoradiotherapy followed by surgical resection for superior sulcus tumors (ssts). | 2008 | 18235125 |
| detection of escherichia coli with fluorescent labeled phages that have a broad host range to e. coli in sewage water. | escherichia coli is used as an indicator microorganism in public health. the conventional way to detect e. coli requires several days to produce a result, because it requires incubation of cells. therefore a rapid and sensitive detection method is needed. t4e-/gfp phage, characterized by suppression of lysozyme and fusion of gfp (green fluorescent protein) to its soc (small outer capsid) protein, was constructed, and it was shown to be able to detect e. coli k12 sensitively within several hours. ... | 2008 | 18225914 |
| fasting-induced changes in the hypothalamus-pituitary-thyroid axis. | fasting induces profound changes in the hypothalamus-pituitary-thyroid (hpt) axis. the alterations observed in humans and rodents are similar in many ways, although they may be more pronounced and more acute in rodents. the molecular mechanisms underlying the resetting of hpt axis regulation in the framework of caloric deprivation are still incompletely understood. fascinating studies in rats and mice have shown a dramatic downregulation of thyrotropin-releasing hormone (trh) gene expression in ... | 2008 | 18225975 |
| changing patterns of vibrio cholerae in sevagram between 1990 and 2005. | a retrospective analysis was done to note changes in prevalence, distribution of biotypes, serotypes, antibiotic susceptibility patterns and phage types of vibrio cholerae isolated in mahatma gandhi institute of medical sciences, sevagram over a period of 16 years. | 2008 | 18227596 |
| polyunsaturated fatty acid metabolizing 15-lipoxygenase-1 (15-lo-1) expression in normal and tumorigenic human bladder tissues. | diets high in fat seem to correspond with an increased risk of certain forms of cancer, including bladder blca. this preliminary study examined the expression and enzyme activity profile of the polyunsaturated fatty acid metabolizing enzyme 15-lipoxygenase-1 (15-lo-1) in human tissues from normal bladder and bladder tumors (stages cis-t3/t4). human tissue samples from normal (donor) bladder and bladder tumors (stages cis-t3/t4; non-bacillus calmette-guerin-treated) were grossly microdissected an ... | 2008 | 18227726 |
| sudden onset of paraplegia caused by hemorrhagic spinal epidural angiolipoma. a case report. | spinal epidural angiolipoma is a rare benign tumor containing vascular and mature adipose elements. a slow progressive clinical course was mostly presented and rarely a fluctuating course during pregnancy. the authors report the original case of spontaneous spinal epidural bleeding resulting from thoracic epidural angiolipoma who presented with hyperacute onset of paraplegia, simulating an extradural hematoma. the patient was admitted with sudden non-traumatic hyperacute paraplegia during a prol ... | 2008 | 18228054 |
| stratified analysis of clinical outcomes in thoracoscopic sympathicotomy for hyperhidrosis. | the primary goal of this study is to identify clinical variables associated with successful surgical treatment for hyperhidrosis and facial blushing. | 2008 | 18222231 |
| single-stranded dna-binding protein recruits dna polymerase v to primer termini on reca-coated dna. | translesion dna synthesis (tls) by dna polymerase v (polv) in escherichia coli involves accessory proteins, including reca and single-stranded dna-binding protein (ssb). to elucidate the role of ssb in tls we used an in vitro exonuclease protection assay and found that ssb increases the accessibility of 3' primer termini located at abasic sites in reca-coated gapped dna. the mutant ssb-113 protein, which is defective in protein-protein interactions, but not in dna binding, was as effective as wi ... | 2008 | 18223256 |
| relating circulating thyroid hormone concentrations to serum interleukins-6 and -10 in association with non-thyroidal illnesses including chronic renal insufficiency. | because of the possible role of cytokines including interleukins (il) in systemic non-thyroidal illnesses' (nti) pathogenesis and consequently the frequently associated alterations in thyroid hormone (th) concentrations constituting the euthyroid sick syndrome (ess), we aimed in this research to elucidate the possible relation between il-6 & il-10 and any documented ess in a cohort of patients with nti. | 2008 | 18211669 |
| s1 ribosomal protein functions in translation initiation and ribonuclease regb activation are mediated by similar rna-protein interactions: an nmr and saxs analysis. | the ribosomal protein s1, in escherichia coli, is necessary for the recognition by the ribosome of the translation initiation codon of most messenger rnas. it also participates in other functions. in particular, it stimulates the t4 endoribonuclease regb, which inactivates some of the phage mrnas, when their translation is no longer required, by cleaving them in the middle of their shine-dalgarno sequence. in each function, s1 seems to target very different rnas, which led to the hypothesis that ... | 2008 | 18211890 |
| tempol improves renal hemodynamics and pressure natriuresis in hyperthyroid rats. | hyperthyroidism in rats is associated with increased oxidative stress. these animals also show abnormal renal hemodynamics and an attenuated pressure-diuresis-natriuresis (pdn) response. we analyzed the role of oxidative stress as a mediator of these alterations by examining acute effects of tempol, a superoxide dismutase mimetic. the effects of increasing bolus doses of tempol (25-150 micromol/kg) on mean arterial pressure (map), renal vascular resistance (rvr), and cortical (cbf) and medullary ... | 2008 | 18216138 |
| thyroid disrupting chemicals: mechanisms and mixtures. | environmental contaminants are known to act as thyroid disrupting chemicals (tdcs). broadly defined, tdcs are xenobiotics that alter the structure or function of the thyroid gland, alter regulatory enzymes associated with thyroid hormone (th) homeostasis or change circulating or tissue concentrations of ths. for ths, homeostasis is defined as the normal range of ths and tsh in circulation and tissues. tdcs include a wide range chemical structures that act through a variety of mechanisms. concern ... | 2008 | 18217984 |
| structure of escherichia coli exonuclease i in complex with thymidine 5'-monophosphate. | in escherichia coli, exonuclease i (exoi) is a monomeric processive 3'-5' exonuclease that degrades single-stranded dna. the enzyme has been implicated as primarily being involved in repairing frameshift mutations. the structure of the enzyme has previously been determined in a hexagonal space group at 2.4 a resolution. here, the structure of exoi in complex with a nucleotide product, thymidine 5'-monophosphate, is described in an orthorhombic space group at 1.5 a resolution. this new high-resol ... | 2008 | 18219121 |
| a prospective, open-label study of low-dose total skin electron beam therapy in mycosis fungoides. | to determine the effect of low-dose (4 gy) total skin electron beam therapy as a second-line treatment of stage ib-ii mycosis fungoides in a prospective, open-label study. | 2008 | 18207669 |
| frequency and characteristics of tbii-seronegative patients in a population with untreated graves' hyperthyroidism: a prospective study. | it is claimed that second generation thyrotropin-binding inhibitory immunoglobulin (tbii) assays have a very high sensitivity for the diagnosis of graves' hyperthyroidism (gh). however, studies evaluating the accuracy of tbii have been retrospective in nature and/or gh had not been diagnosed independently of tbii. the aim of the present study, therefore, was to prospectively evaluate the frequency and characteristics of tbii-seronegative patients in a population of untreated gh diagnosed indepen ... | 2008 | 18208575 |
| thyrotropin serum concentrations in healthy volunteers are associated with depression-related personality traits. | alterations of the hypothalamic-pituitary-thyroid system at the hypophyseal level have been described in affective disorders. the neo five-factor inventory is a widely used instrument, which assesses neuroticism, a strong marker for vulnerability to depression. | 2008 | 18182832 |
| controlling the reactivity of adsorbed dna on template surfaces. | the ability to place dna on surfaces with increased and controllable reactivity is of fundamental importance in the development of next-generation dna and protein biochips. the present work demonstrates the ability to control both the localization of the dna on a surface and its reactivity by a self-assembly approach that is dependent on two variables: dna structure and surface environment. here we utilize a two-step adsorption scheme to control the adsorption and reactivity of dna embedded with ... | 2008 | 18184019 |
| conversion rate in 300 laparoscopic rectal resections and its influence on morbidity and oncological outcome. | the negative influence of conversion from laparoscopic to open colorectal resection on early postoperative morbidity and outcome has been demonstrated several times. in this study, we analyzed the conversion rate and its influence on early postoperative morbidity and short-term oncological outcome following laparoscopic rectal resections. | 2008 | 18185938 |
| effect of selenium and copper supplementation on blood metabolic profile in male buffalo (bubalus bubalis) calves. | twenty male buffalo calves (8-9 months, 112.1 +/- 7.69 kg) were divided into four groups of five animals in each and fed diets without (t1) or supplemented with 0.3 ppm selenium (se) (t2), 0.3 ppm se + 10 ppm copper (cu) (t3), and 10 ppm cu (t4) for 120 days during which blood samples were collected on day 0, 40, 80, and 120. concentrations of glucose, total protein, urea, uric acid, and creatinine were similar in all the four groups, but the level of globulin was significantly (p < 0.01) increa ... | 2008 | 18185997 |
| thyroid function and body weight programming by neonatal hyperthyroidism in rats - the role of leptin and deiodinase activities. | several authors have shown that secondary hypothyroidism was programed by neonatal thyroxine (t4) treatment. however, the associated changes of body weight (bw) were less studied, especially those related to the body fat proportion. here, we have evaluated the effect of neonatal thyroxine treatment on bw, fat proportion, serum leptin, and thyroid function of 60-day-old rats. wistar rats were treated with thyroxine (50 microg/100 g bw, ip) (t) or saline (s), during the first 10 days of life. bw, ... | 2008 | 18197581 |
| dose estimation and surveillance of mechanical loading interventions for bone loss after spinal cord injury. | the interpretation of the results of previous anti-osteoporosis interventions after spinal cord injury (sci) is undermined by incomplete information about the intervention dose or patient adherence to dose requirements. rehabilitation research as a whole traditionally has struggled with these same issues. the purpose of this case report is to offer proof of the concepts that careful dose selection and surveillance of patient adherence should be integral components in rehabilitation interventions ... | 2008 | 18202080 |
| patterns of failure after combined-modality approaches incorporating radiotherapy for sinonasal undifferentiated carcinoma of the head and neck. | to report the clinical outcome of patients treated with combined-modality approaches for sinonasal undifferentiated carcinoma (snuc) of the head and neck. | 2008 | 18207030 |
| fabrication of ordered metallic and magnetic heterostructured dna-nanoparticle hybrids. | here we provide a method based on enzymatically catalyzed reactions to cleave and ligate dna molecules coated with nanoparticles to fabricate multi-component structures. this is done by simultaneously digesting two solutions of nanoparticle coated dna, one with iron oxide particles the other gold particles, which yields short dna fragments with complementary single stranded overhangs. when added together and re-attached using ligase enzymes multi-component nanoparticle coated structures are form ... | 2008 | 18207375 |
| spatial and temporal distribution patterns of na-k-2cl cotransporter in adult and developing mouse retinas. | the na-k-2cl cotransporter (nkcc) is a cl(-) uptake transporter that is responsible for maintaining a cl(-) equilibrium potential positive to the resting potential in neurons. if nkcc is active, gaba and glycine can depolarize neurons. in view of the abundance of gabaergic and glycinergic synapses in retina, we undertook a series of studies using immunocytochemical techniques to determine the distribution of nkcc in retinas of both developing and adult mice. we found nkcc antibody (t4) labeling ... | 2008 | 18442435 |
| molecular characterization, gene expression and transcriptional regulation of cytosolic hsp90 genes in the flatfish senegalese sole (solea senegalensis kaup). | hsp90 proteins are chaperones that play a pivotal role in controlling multiple regulatory pathways such as stress defense, hormone signalling, cell cycle control, cell proliferation and differentiation, and apoptosis. in this study, two cdnas encoding for cytosolic hsp90, referred to as hsp90aa and hsp90ab, have been sequenced. main features and sequence identities with other fish and mammals are described. phylogenetic analysis grouped both genes into two separate clusters with their fish and m ... | 2008 | 18442885 |
| effects of a multifaceted psychiatric intervention targeted for the complex medically ill: a randomized controlled trial. | this study evaluated a multifaceted psychiatric intervention targeted at the complex medically ill identified by means of the intermed, an instrument to assess case complexity. | 2008 | 18443391 |
| novobiocin inhibits the self-splicing of the primary transcripts of t4 phage thymidylate synthase gene. | effects of the antibiotic novobiocin on the self-splicing of primary transcripts of the phage t4 thymidylate synthase gene (td) have been investigated. novobiocin at 10 mm concentration inhibited the splicing by about 5% but at 40 mm concentration the splicing rate was inhibited by about 50%. the novobiocin inhibition of the self-splicing reaction was not reversed even at a high concentration (200 microm) of guanosine. however, increasing the mg(2+) ion concentrations up to 20 mm almost fully re ... | 2008 | 18443742 |
| [idiopathic spinal epidural hematoma in patients with sudden paraplegia: a case report]. | spontaneous spinal epidural hematoma (seh) represents 0.3-0.9% of spinal epidural space-occupying lesions, and most surgeons advocate aggressive and early surgical intervention. in this paper we describe a patient with seh with sudden paraplegia. | 2008 | 18446696 |
| linear growth, growth-hormone secretion and igf-i generation in children with neglected hypothyroidism before and after thyroxine replacement. | we studied growth hormone (gh) stimulation and insulin-like growth factor -i (igf-i) generation tests in 15 children with neglected congenital hypothyroidism (ch) (age = 6.4 +/- 4.2 years) and measured their growth parameters for >1 years after starting thyroxine (t4) replacement. one year after treatment, height sds (htsds) increased from -4.3 +/- 2.5 to -2.7 +/- 2.3. peak gh response to clonidine increased from 3.2 +/- 1.2 ng ml(-1) to 7.62 +/- 1.38 ng ml(-1) after treatments. basal and peak i ... | 2008 | 18450819 |
| lack of a co-promotion effect of 60 hz rotating magnetic fields on n-ethyl-n-nitrosourea induced neurogenic tumors in f344 rats. | the present study was conducted to investigate the possible effect of 60 hz magnetic fields as promoters of brain tumors initiated transplacentally by ethylnitrosourea (enu) in f344 rats. one hundred twenty mated animals were divided into six different groups and exposed in utero on day 18 of gestation to a single intravenous dose of either saline (vehicle control, group i), or enu 10 mg/kg (groups ii-vi). in the present study, a total of 480 offspring was used. the offspring in group ii were gi ... | 2008 | 18452166 |
| the effect of gene therapy using ctla4ig/silica-nanoparticles on canine experimental autoimmune thyroiditis. | the present study aimed to determine the effect of canine ctla4ig on canine autoimmune thyroiditis. in a previous study, we established a canine model of autoimmune thyroiditis by immunizing normal dogs with bovine thyroglobulin. an in vitro study using recombinant ctla4ig revealed that this protein can inhibit the expression of th1-type cytokines and the pro-inflammatory cytokines tested. | 2008 | 18452240 |
| prognostic factors of renal cell carcinoma with extension into inferior vena cava. | to evaluate the prognosis of our series of patients with renal cell carcinoma (rcc) and tumor thrombus involving inferior vena cava (ivc) treated with nephrectomy and thrombectomy. | 2008 | 18452454 |
| staphylococcus aureus primase has higher initiation specificity, interacts with single-stranded dna stronger, but is less stimulated by its helicase than escherichia coli primase. | the study of primases from model organisms such as escherichia coli, phage t7 and phage t4 has demonstrated the essential nature of primase function, which is to generate de novo rna polymers to prime dna polymerase. however, little is known about the function of primases from other eubacteria. their overall low primary sequence homology may result in functional differences. to help understand which primase functions were conserved, primase and its replication partner helicase from the pathogeni ... | 2008 | 18452509 |
| predictors of positive radial margin status in a population-based cohort of patients with rectal cancer. | surgical margin status is an important predictor of risk of relapse among patients with rectal cancer. | 2008 | 18454185 |
| dissection of the bacteriophage t4 late promoter complex. | activated transcription of the bacteriophage t4 late genes is generated by a mechanism that stands apart from the common modalities of transcriptional regulation: the activator is gp45, the viral replisome's sliding clamp; two sliding-clamp-binding proteins, gp33 and gp55, replace the host rna polymerase (rnap) sigma subunit. we have mutagenized, reconfigured and selectively disrupted individual interactions of the sliding clamp with gp33 and gp55 and have monitored effects on transcription. the ... | 2008 | 18455735 |
| beneficial effect of modified egg on serum t3, t4 and dyslipidaemia following dietary zn-supplementation in wistar rat. | a fall in serum t3 and t4 along with increase in serum cholesterol, triglycerides, ldl-c and vldl-c and decrease in hdl-c was observed in albino wistar rats when fed on semi-synthetic diet containing either 40 or 80mg zn/kg diet. zn concentrations were observed to increase with decreased concentration of cu and mg in their tissues. on including modified egg (indian patent application no. 2264\del\2005) in the zn supplement diet, the levels of t3 and t4, lipid profile in serum and mineral status ... | 2008 | 18432056 |
| fibrinolysis or hypercoagulation during radical prostatectomy? an evaluation of thrombelastographic parameters and standard laboratory tests. | radical prostatectomy is at high risk for intraoperative and postoperative bleeding due to surgical trauma, release of urokinase and tissue type plasminogen activator. we conducted this prospective, observational multi-centre study to assess the degree of systemic fibrinolysis or hypercoagulation in the perioperative period. we studied serial changes in standard laboratory values and in thrombelastographic (teg; haemoscope corporation, skokie, il, usa) parameters including lysis at 30 and 60 min ... | 2008 | 18339213 |
| clinicopathologic characteristics and prognosis for young gastric adenocarcinoma patients after curative resection. | conflicting results from previous studies on gastric adenocarcinoma (gc) in young patients have led to controversy surrounding the prognosis for young gc patients. | 2008 | 18340495 |
| [perineal wound complications following preoperative radiotherapy for rectal cancer]. | every year, approximately 1200 new cases of rectal cancer are registered in denmark. preoperative radiation therapy alone or in combination with chemotherapy (chemo-radiation) is a gold standard in the treatment of patients with t3 and t4 tumours. although it carries a good response rate, preoperative radiation is associated with significant morbidity including wound infection and delayed healing. the aim of this study is to clarify the effects of preoperative radiotherapy on wound healing in pa ... | 2008 | 18433575 |
| intracranial hypotension following scoliosis surgery: dural penetration of a thoracic pedicle screw. | the authors report on a 14 years old female with intracranial hypotension who had a history of spinal instrumentation surgery for scoliosis 3 months prior to her admission. she had been diagnosed with migraine in a neurology clinic and was under medical therapy when presented. during the investigation process, a right thoracic pedicle screw, which was penetrating and transversing the dura mater at the t3-t4 level was identified. the diagnosis and management of such a case is discussed. knowledge ... | 2008 | 18437432 |
| cationic agents for dna compaction. | fluorescence microscopy was used to investigate the conformational changes of individual t4 dna molecules induced by different compacting agents, namely the cationic surfactants, cetyltrimethylammonium bromide (ctab) and chloride (ctac), iron(iii), lysozyme, and protamine sulfate. a protocol for establishing size estimates is suggested to obtain reproducible results. observations show that in the presence of lysozyme and protamine sulfate, dna molecules exhibit a conformational change from an el ... | 2008 | 18440012 |
| environment and endocrinology: the case of thyroidology. | evidence is accumulating for interference of selected endocrine disrupting chemicals (edc) with the thyroid axis. edc disturb thyroid hormone (th) homeostasis leading to developmental defects, hypothyroidism and altered thyroid growth patterns. a rising incidence of papillary thyroid carcinoma (ptc) in several western countries cannot be definitely accounted for by improved diagnosis or management of thyroid cancer or improved iodine supply. in recent studies, we and others detected, within the ... | 2008 | 18440490 |
| exonuclease activity of proofreading dna polymerases is at the origin of artifacts in molecular profiling studies. | ce fingerprint methods are commonly used in microbial ecology. we have previously noticed that the position and number of peaks in ce-sscp (single-strand conformation polymorphism) profiles depend on the dna polymerase used in pcr [1]. here, we studied the fragments produced by taq polymerase as well as four commercially available proofreading polymerases, using the v3 region of the escherichia coli rss gene as a marker. pcr products rendered multiple peaks in denaturing ce; taq polymerase was o ... | 2008 | 18429330 |
| effects of t4 replacement therapy on glucose metabolism in subjects with subclinical (sh) and overt hypothyroidism (oh). | to evaluate beta-cell function and insulin sensitivity in subjects with overt (oh) and subclinical hypothyroidism (sh) before and after t4 replacement therapy. | 2008 | 18429948 |
| impact of hemoglobin level on survival in definitive chemoradiotherapy for t4/m1 lymph node esophageal cancer. | we retrospectively investigated the impact of the pre-chemoradiotherapy hemoglobin level (pre-crt hb level) for t4 and/or m1 lymph node (lym) squamous cell carcinoma of the esophagus. chemotherapy consisted of protracted infusion with 5-fluorouracil (5-fu) at 400 mg/m(2)/day on days 1-5 and 8-12, combined with cisplatin at 40 mg/m(2)/day on days 1 and 8, repeated twice at a 5-week interval. concurrent radiation therapy was started on day 1 and delivered at 2 gy/day for five days a week for a tot ... | 2008 | 18430098 |
| the effects of subchronic acrylamide exposure on gene expression, neurochemistry, hormones, and histopathology in the hypothalamus-pituitary-thyroid axis of male fischer 344 rats. | acrylamide (aa) is an important industrial chemical that is neurotoxic in rodents and humans and carcinogenic in rodents. the observation of cancer in endocrine-responsive tissues in fischer 344 rats has prompted hypotheses of hormonal dysregulation, as opposed to dna damage, as the mechanism for tumor induction by aa. the current investigation examines possible evidence for disruption of the hypothalamic-pituitary-thyroid axis from 14 days of repeated exposure of male fischer 344 rats to doses ... | 2008 | 18430446 |
| does endoesophageal ultrasound-guided fine-needle aspiration replace mediastinoscopy in mediastinal staging of thoracic malignancies? | to determine the impact of endoesophageal ultrasound-guided fine-needle aspiration (eus-fna) on management of thoracic malignancies. | 2008 | 18430581 |
| comparison of the effects of octreotide and melatonin in preventing nerve injury in rats with experimental spinal cord injury. | in this study, we aimed to investigate the biochemical and histopathological protective effects of octreotide and melatonin in an experimental model of spinal cord injury. fifty- six male albino wistar rats were divided into four groups. rats in the g1 group (n=7; control group) did not undergo any treatment except for anesthesia prior to being killed. rats in the g2 group (n=7) underwent laminectomy and aneurysmal clip application at the t4-5 level. g3 group rats (n=14) were either treated with ... | 2008 | 18407497 |
| [a case of advanced esophageal cancer with large liver metastasis successfully treated with fap therapy]. | a 70-year-old man with dysphagia was diagnosed as advanced esophageal cancer by a primary doctor, and he was admitted to our hospital for treatment in february, 2004. the pretreatment diagnosis was basaloid squamous carcinoma, mt area, t4 (aorta) , n2 (no. 107) , m1 (liver), stage ivb performed systemic chemotherapy by fap (5-fluorouracil ( 5-fu)+doxorubicin (dxr)+cisplatin (cddp) ) from march, 2004. after 4 courses, the local tumor almost entirely disappeared, and the liver metastasis was obvio ... | 2008 | 18408432 |
| human replication protein a melts a dna triple helix structure in a potent and specific manner. | alternate dna structures other than double-stranded b-form dna can potentially impede cellular processes such as transcription and replication. the dna triplex helix and g4 tetraplex structures that form by hoogsteen hydrogen bonding are two examples of alternate dna structures that can be a source of genomic instability. in this study, we have examined the ability of human replication protein a (rpa), a single-stranded dna binding protein that is implicated in all facets of dna metabolism, to d ... | 2008 | 18410127 |
| expression of runx3 in salivary adenoid cystic carcinoma: implications for tumor progression and prognosis. | runt-related transcription factor-3 (runx3), being a tumor suppressor gene in gastric cancer, plays an important role in inhibiting cellular growth by participating in the transforming growth factor-beta-dependent apoptosis. the aim of this study was to determine the expression of runx3 in normal salivary glands and adenoid cystic carcinomas (accs), comparing the results with clinicopathological factors and patient survival. the quantitative reverse transcription-polymerase chain reaction (rt-pc ... | 2008 | 18410404 |
| evaluation of dynamic sentinel lymph node biopsy in patients with squamous cell carcinoma of the penis and palpable inguinal nodes. | to evaluate dynamic sentinel lymph node biopsy (dslnb) in patients with squamous cell carcinoma (scc) of the penis and palpable inguinal lymph nodes, using inguinal lymph node dissection (ilnd) as the reference standard to assess the reliability of dslnb, as using radioscintigraphy and colloidal blue-dye injection to locate the sln was reported to be a useful technique to avoid ilnd in men with scc of the penis and clinically impalpable nodes. | 2008 | 18410439 |
| diagnosis and management of amiodarone-induced thyrotoxicosis: similarities and differences between north american and european thyroidologists. | to investigate how north american thyroidologists assess and treat amiodarone-induced thyrotoxicosis (ait) and to compare the results with those of the same questionnaire-based survey previously carried out among european thyroidologists. | 2008 | 18410546 |
| polymorphisms in the brain-specific thyroid hormone transporter oatp1c1 are associated with fatigue and depression in hypothyroid patients. | some hypothyroid patients continue to have significant impairments in psychological well-being, despite adequate treatment with levothyroxine (lt4). t4 transport across the blood-brain barrier is one of the crucial processes for thyroid hormone action in the brain. oatp1c1, a thyroid hormone transporter expressed at the blood-brain barrier, is considered to play a key role in delivering serum t4 to the brain. | 2008 | 18410547 |
| arterial chemoradiotherapy for locally advanced tongue cancer: analysis of retrospective study of therapeutic results in 88 patients. | to retrospectively investigate the therapeutic results of arterial injection therapy by way of the superficial temporal artery for 88 cases of stage iii and iv (m0) tongue cancer and to clarify the factors that affected the therapeutic results. | 2008 | 18411003 |
| parametrization, molecular dynamics simulation, and calculation of electron spin resonance spectra of a nitroxide spin label on a polyalanine alpha-helix. | the nitroxide spin label 1-oxyl-2,2,5,5-tetramethylpyrroline-3-methyl-methanethiosulfonate (mtssl), commonly used in site-directed spin labeling of proteins, is studied with molecular dynamics (md) simulations. after developing force field parameters for the nitroxide moiety and the spin label linker, we simulate mtssl attached to a polyalanine alpha-helix in explicit solvent to elucidate the factors affecting its conformational dynamics. electron spin resonance spectra at 9 and 250 ghz are simu ... | 2008 | 18412413 |
| hepatocellular integrity in patients requiring parenteral nutrition: comparison of structured mct/lct vs. a standard mct/lct emulsion and a lct emulsion. | the aetiology of parenteral nutrition-associated hepatic injury remains unresolved. the aim of the study was to evaluate the effects of structured triglycerides in parenteral nutrition compared either to a physical medium-chain triglycerides (mct)/long-chain triglcerides (lct) mixture or to a lct emulsion on hepatic integrity. | 2008 | 18413006 |
| ten-year follow-up of radiation therapy oncology group protocol 92-02: a phase iii trial of the duration of elective androgen deprivation in locally advanced prostate cancer. | to determine whether adding 2 years of androgen-deprivation therapy (adt) improved outcome for patients electively treated with adt before and during radiation therapy (rt). | 2008 | 18413638 |
| incorporating the amino acid properties to predict the significance of missense mutations. | determining if missense mutations are deleterious is critical for the analysis of genes implicated in disease. however, the mutational effects of many missense mutations in databases like the breast cancer information core are unclassified. several approaches have emerged recently to determine such mutational effects but none have utilized amino acid property indices. we modified a previously described phylogenetic approach by first classifying benign substitutions based on the assumption that m ... | 2008 | 18415037 |