Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| giant t4 rectal carcinoma mimicking urinary bladder adenocarcinoma accurately diagnosed by immunohistochemistry and successfully treated with total pelvic exenteration: report of a case. | a 54-year-old man, with the chief complaints of hematuria, pollakisuria, and pneumaturia, was referred to our hospital, with a diagnosis of giant urinary bladder adenocarcinoma with massive invasion to the rectum. on the basis of the radiological diagnosis and findings of hematoxylin and eosin (h&e) of biopsy specimens, it was difficult to conclude whether the adenocarcinoma originated in the bladder or in the rectum. the immunohistochemical staining of the biopsy specimens showed cytokeratin 7 ... | 2008 | 18307003 |
| pharmacokinetics of total thyroxine in dogs after administration of an oral solution of levothyroxine sodium. | oral l-thyroxine (l-t4) supplementation is used to replace thyroid hormone concentrations in dogs with hypothyroidism. the pharmacokinetics of l-t4 following administration of a solution (leventa) was investigated in healthy dogs. l-t4 was absorbed fairly rapidly (t(max) 3 h). a mean bioavailability of 22% was calculated following a single oral administration of 40 microg l-t4/kg body weight. repeated oral administration at the same dose for 14 consecutive days did not lead to any accumulation o ... | 2008 | 18307500 |
| atrial fibrillation associated with a thyroid stimulating hormone-secreting adenoma of the pituitary gland leading to a presentation of acute cardiac decompensation: a case report. | hyperthyroidism is a well established cause of atrial fibrillation (af). thyroid stimulating hormone-secreting pituitary tumours are rare causes of pituitary hyperthyroidism. whilst pituitary causes of hyperthyroidism are much less common than primary thyroid pathology, establishing a clear aetiology is critical in minimising complications and providing appropriate treatment. measuring thyroid stimulating hormone (tsh) alone to screen for hyperthyroidism may be insufficient to appropriately eval ... | 2008 | 18307779 |
| selective arterial prostatic embolization (sape) for refractory hematuria of prostatic origin. | to assess sape as an alternative treatment option in patients with refractory hematuria of prostatic origin. | 2008 | 18308078 |
| novel azaphilones, kasanosins a and b, which are specific inhibitors of eukaryotic dna polymerases beta and lambda from talaromyces sp. | kasanosins a (1) and b (2) are novel azaphilones isolated from cultures of talaromyces sp. derived from seaweed, and their structures were determined by spectroscopic analyses. these compounds selectively inhibited the activities of eukaryotic dna polymerases beta and lambda (pols beta and lambda) in family x of pols, and compound 1 was a stronger inhibitor than compound 2. the ic(50) values of compound 1 on rat pol beta and human pol lambda were 27.3 and 35.0 microm, respectively. on the other ... | 2008 | 18308572 |
| long-term outcome following radical temporal bone resection for lateral skull base malignancies: a neurosurgical perspective. | primary temporal bone malignancy is a rare form of tumor for which the therapeutic strategy remains controversial. in this study, the authors reviewed their experience with radical temporal bone resection (tbr) of such lesions and analyzed the long-term results to provide treatment recommendations. | 2008 | 18312097 |
| gender differences in the effects of organochlorines, mercury, and lead on thyroid hormone levels in lakeside communities of quebec (canada). | environmental chemicals can disrupt endocrine balance and in particular thyroid hormone (th) homeostasis. however, studies differ with respect to thyroid profile changes and gender differences are rarely examined. this study investigated the ths, triodothyronine (t3), thyroxine (t4), and thyroid stimulating hormone (tsh), in relation to serum organochlorines (ocs), bioindicators of mercury (hg) and blood lead (pb) in 211 freshwater fish consumers (124 men and 87 women) from two communities in ca ... | 2008 | 18313043 |
| feasibility of vermicomposting in biostabilization of sludge from a distillery industry. | the feasibility of vermicomposting technology to stabilize the distillery industry sludge mixed with a bulking agent (cow dung) in different proportions viz. 20% (t1), 40% (t2), 60% (t3) and 80% (t4), was tested using composting earthworm perionyx excavatus for 90 days. the vermitreated sludge was evaluated for different physico-chemical parameters and all vermibeds expressed a significant decrease in ph (10.5-19.5%) organic c contents (12.8-27.2%), and an increase in total n (128.8-151.9%), ava ... | 2008 | 18313726 |
| origin activation requires both replicative and accessory helicases during t4 infection. | the bacteriophage t4 has served as an in vitro model for the study of dna replication for several decades, yet less is known about this process during infection. recent work has shown that viral dna synthesis is initiated from at least five origins of replication distributed across the 172 kb chromosome, but continued synthesis is dependent on recombination. two proteins are predicted to facilitate loading of the hexameric 41 helicase at the origins, the dda accessory helicase and the 59 loading ... | 2008 | 18314134 |
| do existing psychologic scales measure the nonspecific benefit associated with cam treatment? | to determine whether existing psychologic well-being scales are sensitive to change after complementary and alternative medicine (cam) treatment, and whether changes in those scales of well-being correlate with symptom change. this may limit the need for the development of new cam-specific outcomes. | 2008 | 18315505 |
| tumor-infiltrating lymphocytes and perforation in colon cancer predict positive response to 5-fluorouracil chemotherapy. | the major pathologic markers of prognosis in colorectal cancer include vascular invasion by tumor cells, invasion of adjacent lymph nodes, and perforation of the serosal wall. recent work suggests that a high density of tumor-infiltrating lymphocytes (til) is associated with good outcome independently of these established prognostic markers. the aim of the present study was to investigate the prognostic significance of tils and other routinely reported pathologic features in colon cancer, partic ... | 2008 | 18316563 |
| validation study of the proposed iaslc staging revisions of the t4 and m non-small cell lung cancer descriptors using data from 23,583 patients in the california cancer registry. | we performed a validation study of the proposed international association for the study of lung cancer (iaslc) tumor, node, metastasis (tnm) and stage grouping revisions on advanced nonbronchioloalveolar carcinoma (non-bac) non-small cell lung cancer (nsclc). | 2008 | 18317063 |
| visuomotor expertise and dimensional complexity of cerebral cortical activity. | this study employed the correlation dimension (d2) to examine whether visuomotor expertise was inversely related to the complexity of cerebral cortical activity. | 2008 | 18317368 |
| the multiple benefits of minimally invasive spinal surgery: results comparing transforaminal lumbar interbody fusion and posterior lumbar fusion. | minimally invasive transforaminal lumbar interbody fusion (tlif) offers equivalent postoperative fusion rates compared to posterior lumbar fusion (plf) and minimizes the amount of iatrogenic injury to the spinal muscles. the objective of this study was to examine the difference in pain perception, stress, mood disturbance, quality of life, and immunological indices throughout the perioperative course among patients undergoing tlif and plf. a prospective, nonrandomized descriptive design was used ... | 2008 | 18330408 |
| [peripheral blood t-lymphocyte and t-lymphocyte subset ratios before and after treatment in schizophrenia patients not taking antipsychotic medication]. | immune system abnormalities in schizophrenia have been previously studied. according to the present point of view, an infection or autoimmune process might be occurring in the form of cellular and/or humoral immune system abnormalities in schizophrenia. furthermore, several effects of antipsychotic medication on the immunological profile of schizophrenic patients have been demonstrated. the present study aimed to compare the total t-lymphocytes level and the t-lymphocyte subset ratios in schizop ... | 2008 | 18330738 |
| staging accuracy of esophageal cancer by endoscopic ultrasound: a meta-analysis and systematic review. | to evaluate the accuracy of endoscopic ultrasound (eus) in the staging of esophageal cancer. | 2008 | 18330935 |
| hypoechoic thyroid nodules on ultrasound 4 years after prenatal exposure to radioiodine: resolution with thyroxine therapy. | we describe an infant inadvertently exposed to radioiodine at 17 weeks gestation. his mother had received 400 mbq of (131)i for hyperthyroidism (total t4 178 nmol/l, thyroid stimulating hormone (tsh) <0.1 mu/l, 4-h (131)i uptake 16%). following cordocentesis at 27 weeks (free t4 12.7 pmol/l, tsh 35.4 mu/l) intra-amniotic thyroxine was withheld and a male infant was born at 39 weeks gestation, birthweight 3520 g. cord tsh was low (0.1 mu/l), total t4 151 nmol/l on day 4, the mother having receive ... | 2008 | 18331366 |
| laryngeal chondritis induced by c3-4 osteophyte following supracricoid laryngectomy with cricohyoidoepiglottopexy: report of two cases. | we have performed supracricoid laryngectomy with cricohyoidoepiglottopexy or with cricohyoidopexy for tumour (t) stage t2 and t3 laryngeal cancer cases and some t4 cases. we report the clinical symptoms and management, using this technique to avoid complications. | 2008 | 18331655 |
| [mouth floor and mobile tongue epidermoid carcinomas thickness: prognostic value]. | most cancers of the oral cavity are epidermoid carcinomas. the prognosis is made on the patient's general health status and the tumoral stage. the uicc tnm staging classification system is one of the most important factors taken in consideration for the prognosis. but this classification in oral epidermoid carcinomas does not include the tumor thickness (except for t4 tumors). several studies demonstrated that tumor thickness could influence the prognosis in epidermoid carcinoma and other types ... | 2008 | 18328517 |
| fibril formation of hsp10 homologue proteins and determination of fibril core regions: differences in fibril core regions dependent on subtle differences in amino acid sequence. | heat shock protein 10 (hsp10) is a member of the molecular chaperones and works with hsp60 in mediating various protein folding reactions. groes is a representative protein of hsp10 from escherichia coli. recently, we found that groes formed a typical amyloid fibril from a guanidine hydrochloride (gdn-hcl) unfolded state at neutral ph. here, we report that other hsp10 homologues, such as human hsp10 (hhsp10), rat mitochondrial hsp10 (rhsp10), gp31 from t4 phage, and hsp10 from the hyperthermophi ... | 2008 | 18329043 |
| identification of patients with high-risk stage ii colon cancer for adjuvant therapy. | adjuvant therapy for stage ii colon cancer remains controversial but may be considered for patients with high-risk features. the purpose of this study was to assess the prognostic significance of commonly reported clinicopathologic features of stage ii colon cancer to identify high-risk patients. | 2008 | 18322753 |
| dry small pleural dissemination of adenocarcinoma of the lung preoperatively detected by pet/ct: a report of two cases. | dry pleural dissemination in non-small cell lung cancer, defined as solid pleural metastasis of lung cancer without pleural effusion, is a condition occurring in t4 lung cancer. positron emission tomography (pet) has been reported to be useful for the diagnosis and staging of lung cancer. it has been reported that positive findings on pet scans of indeterminate pleural abnormalities at computed tomography (ct) are sensitive to malignancy. we encountered two cases of dry small pleural disseminati ... | 2008 | 18323864 |
| papillary thyroid carcinoma: factors influencing recurrence and survival. | the prognosis of patients with papillary thyroid carcinoma (ptc) is usually favorable; however, a subset of patients can develop local recurrence or distant metastases. the aim of this study was to evaluate the prognostic factors influencing the recurrence and the survival rate in 950 ptc patients. | 2008 | 18324441 |
| thyrotoxic periodic paralysis in an italian man: clinical manifestation and genetic analysis. | in western countries, thyrotoxic periodic paralysis (tpp) is a rare condition with only sporadic cases described so far. here, we describe a 29-year-old italian man who presented with leg weakness and hypokalaemia. treatment with intravenous potassium resulted in a rapid resolution of symptoms. tpp as the underlying cause was suggested by suppressed thyroid-stimulating hormone (tsh), elevated free t3 and free t4, and the presence of tsh-receptor antibodies (trab). genetic analysis showed no muta ... | 2008 | 18325191 |
| atp-induced shrinkage of dna with mukb protein and the mukbef complex of escherichia coli. | fluorescence microscopic observation of individual t4 dna molecules revealed that the mukbef complex (bacterial condensin) and its subunit, the mukb (a member of the smc [structural maintenance of chromosomes] superfamily) homodimer, of escherichia coli markedly shrunk large dna molecules in the presence of hydrolyzable atp. in contrast, in the presence of adp or atp-gammas, the conformation of dna was almost not changed. this suggests that the atpase activity of subunit mukb is essential for sh ... | 2008 | 18326568 |
| orf334 in vibrio phage kvp40 plays the role of gp27 in t4 phage to form a heterohexameric complex. | kvp40 is a t4-related phage, composed of 386 open reading frames (orfs), that has a broad host range. here, we overexpressed, purified, and biophysically characterized two of the proteins encoded in the kvp40 genome, namely, gp5 and orf334. homology-based comparison between kvp40 and its better-characterized sister phage, t4, was used to estimate the two kvp40 proteins' functions. kvp40 gp5 shared significant homology with t4 gp5 in the n- and c-terminal domains. unlike t4 gp5, kvp40 gp5 lacked ... | 2008 | 18326574 |
| [effect of isoflurane delayed preconditioning on myocardial ischemia reperfusion injury in rabbits]. | to investigate the protective effect of isoflurane delayed preconditioning on myocardial ischemia reperfusion injury and the potential mechanism in rabbits. | 2008 | 18326909 |
| effect of hypothyroidism on the purinergic responses of corpus cavernosal smooth muscle in rabbits. | several studies have reported evidence of hormonal abnormalities in 25-35% of impotent men. hypothyroidism has been reported to occur in 6% of impotent men. in the present study, we examined purinergic relaxation responses in hypothyroidism in an experimental rabbit model and compared them with controls to evaluate the possible involvement of the purinergic pathway. | 2008 | 18327655 |
| imaging of idiopathic spinal cord herniation. | idiopathic spinal cord herniation, unlike spinal cord herniation with a known traumatic or postoperative origin, is a relatively rare condition; however, it has been diagnosed and reported with increasing frequency in recent years. such herniation most often occurs in the thoracic spine, between the t4 and t7 vertebrae. brown-séquard syndrome is the most frequently reported clinical feature. early manifestations may include numbness and decreased temperature sensation in the legs, gait disturban ... | 2008 | 18349454 |
| phase ii study of capecitabine and oxaliplatin given prior to and concurrently with preoperative pelvic radiotherapy in patients with locally advanced rectal cancer. | this multicentre phase ii study evaluated the efficacy and safety of preoperative capecitabine plus oxaliplatin and radiotherapy (rt) in patients with locally advanced rectal cancer (t3/t4 rectal adenocarcinoma with or without nodal involvement). treatment consisted of one cycle of xelox (capecitabine 1000 mg m(-2) bid on days 1-14 and oxaliplatin 130 mg m(-2) on day 1), followed by rt (1.8 gy fractions 5 days per week for 5 weeks) plus capox (capecitabine 825 mg m(-2) bid on days 22-35 and 43-5 ... | 2008 | 18349837 |
| preoperative t staging of colorectal cancer by ct colonography. | this study was designed to estimate the accuracy of ct colonography for the assessment of t stage in colorectal cancer. | 2008 | 18350337 |
| concomitant boost radiotherapy compared with conventional radiotherapy in squamous cell carcinoma of the head and neck--a phase iii trial from a single institution in india. | to test the efficacy of an accelerated fractionation schedule (concomitant boost) against standard conventional fractionation in squamous cell carcinomas of the head and neck region in our patient population. | 2008 | 18343310 |
| [cervicomanubrial route for the ventral upper thoracic spine: technical note about six cases]. | ventrolateral cervicotomy provides a narrowed working space for surgical management of upper thoracic spine. we report our experience about ventral upper thoracic spinal cord decompression with reconstruction and plating via the cervicomanubrial route. six patients (24 to 75 years old) were operated on by the same operator (ln) by cervicomanubriotomy from 2002 to 2007 for upper thoracic spinal cord compression (one case of pott's disease, three cases of metastases, one fracture, one invasive hem ... | 2008 | 18343460 |
| the virulence regulator sae of staphylococcus aureus: promoter activities and response to phagocytosis-related signals. | the two-component system saers of staphylococcus aureus is closely involved in the regulation of major virulence factors. however, little is known about the signals leading to saers activation. a total of four overlapping transcripts (t1 to t4) from three different transcription starting points are expressed in the sae operon. we used a beta-galactosidase reporter assay to characterize the putative promoter regions within the saers upstream region. the main transcript t2 is probably generated by ... | 2008 | 18344360 |
| [transient neonatal hypothyroidism due to amiodarone administration during pregnancy--two cases report and review of literature]. | introduction: amiodarone (amd) is an antiarrhythmic agent which contains 37% of iodine. it can reach the fetus by transplacental passage and induce transient congenital hypothyroidism (tch). we report two cases of tch caused by gestational exposure to amd, detected by the newborn screening program for congenital hypothyroidism of the state of paraná-brazil. clinical case 1 (c1): neonatal tsh value was 78.2 mu/l (normal<15 mu/l). amd had been given to the mother during pregnancy to treat maternal ... | 2008 | 18345406 |
| significant inverse relationship between serum free t4 concentration and body mass index in euthyroid subjects: differences between smokers and nonsmokers. | there are conflicting data regarding the relationship between thyroid function and body mass index (bmi) in euthyroid subjects, and it is uncertain whether tobacco smoking modifies this relationship. the objective of this study was to examine the relationships between thyroid function, bmi and smoking in euthyroid subjects. | 2008 | 18346211 |
| blocking noise but not music lowers bispectral index scores during sedation in noisy operating rooms. | to determine whether playing music or blocking noise can reduce bispectral index (bis) values during propofol sedation. | 2008 | 18346603 |
| altered intestinal absorption of l-thyroxine caused by coffee. | to report eight case histories, and in vivo and in vitro studies showing coffee's potential to impair thyroxine (t4) intestinal absorption. | 2008 | 18341376 |
| identification of dio2 as a new susceptibility locus for symptomatic osteoarthritis. | osteoarthritis [mim 165720] is a common late-onset articular joint disease for which no pharmaceutical intervention is available to attenuate the cartilage degeneration. to identify a new osteoarthritis susceptibility locus, a genome-wide linkage scan and combined linkage association analysis were applied to 179 affected siblings and four trios with generalized osteoarthritis (the garp study). we tested, for confirmation by association, 1478 subjects who required joint replacement and 734 contro ... | 2008 | 18334578 |
| effects of the hormones of the thyroid axis on the vitamin k-dependent plasma factors of blood coagulation (ii, vii, ix, and x). | the hormonal regulation of haemostasis is a problem which has not received much attention. the data concerning the influence of hormones from the hypothalamic-pituitary-thyroid axis are scarce, contradictory and based mainly on clinical observations. the objective of the current research is to study the influence of the thyrotropin releasing hormone (trh), thyroid stimulating hormone (tsh), triiodothyronine (t3) and thyroxin (t4) on the activity level of the vitamin k-dependent plasma factors of ... | 2008 | 18336749 |
| estrone sulfate (e1s), a prognosis marker for tumor aggressiveness in prostate cancer (pca). | seeking insight into the possible role of estrogens in prostate cancer (pca) evolution, we assayed serum e2, estrone (e1), and estrone sulfate (e1s) in 349 pca and 100 benign prostatic hyperplasia (bph) patients, and in 208 control subjects in the same age range (50-74 years). e1 (pmol/l+/-s.d.) and e1s (nmol/l+/-s.d.) in the pca and bph patients (respectively 126.1+/-66.1 and 2.82+/-1.78, and 127.8+/-56.4 and 2.78+/-2.12) were significantly higher than in the controls (113.8+/-47.6 and 2.11+/-0 ... | 2008 | 18337090 |
| acute spontaneous spinal subdural hematoma in a patient with bilateral incarcerated inguinal hernia. | acute spinal subdural hematoma is an infrequent and devastating condition that occurs mostly in patients with coagulopathy or receiving anticoagulants. it may also develop after trauma, spinal surgery or iatrogenically (lumbar puncture and/or spinal anaesthesia). spinal vascular malformations or spinal tumours can also be the origins of subdural hematomas. however, acute spinal subdural hematomas, which are not associated with these risk factors, are seen even more infrequently. in this report, ... | 2008 | 18337142 |
| epidural lidocaine-bicarbonate-adrenaline vs levobupivacaine for emergency caesarean section: a randomised controlled trial. | epidural mixtures containing lidocaine with or without additives are commonly used to convert epidural analgesia in labour to anaesthesia for emergency caesarean section, but direct comparisons with alternative, single agents in this situation are few. in a prospective double-blinded trial, we compared a freshly prepared lidocaine-bicarbonate-adrenaline mixture (final concentrations 1.8%, 0.76% and 1:200,000, respectively) with our standard agent, levobupivacaine 0.5%, for extending epidural blo ... | 2008 | 18289229 |
| orally delivered foot-and-mouth disease virus capsid protomer vaccine displayed on t4 bacteriophage surface: 100% protection from potency challenge in mice. | an orally delivered foot-and-mouth disease (fmd) vaccine has not previously been reported. by using a t4 bacteriophage nanoparticle surface gene-protein display system (t4-s-gpds), we created a foot-and-mouth disease virus (fmdv) entire capsid protein vaccine candidate. on the t4 phage surface soc site, a full length fmdv capsid precursor polyprotein (p1, 755 aa) and proteinase 3c (213 aa) derived from an infected pig of serotype o strain gd-10 (1999), were separately displayed on different t4 p ... | 2008 | 18289743 |
| cardiac output derived from arterial pressure waveform analysis in patients undergoing cardiac surgery: validity of a second generation device. | the performance of a recently introduced, arterial waveform-based device for measuring cardiac output (co) without the need of invasive calibration (flotrac/vigileo) has been controversial. we designed the present study to assess the validity of an improved version of this monitoring technique compared with intermittent thermodilution co measurement using a pulmonary artery catheter in patients undergoing cardiac surgery. | 2008 | 18292432 |
| influence of timed nutrient diet on depression and light sensitivity in seasonal affective disorder. | seasonal affective disorder (sad) patients crave and eat more carbohydrates (cho) in fall-winter when depressed, especially in the evenings, and feel energetic thereafter. evening cho-rich meals can phase delay circadian rhythms, and glucose increases retinal response to light. we studied timed cho- or protein-rich (prot) diet as a putative therapy for sad. unmedicated, dsm-iv-diagnosed depressed women with sad (n=22, 19-63 yrs) in the follicular phase of the menstrual cycle (present in 19) were ... | 2008 | 18293149 |
| direct nmr detection of alkali metal ions bound to g-quadruplex dna. | we describe a general multinuclear (1h, 23na, 87rb) nmr approach for direct detection of alkali metal ions bound to g-quadruplex dna. this study is motivated by our recent discovery that alkali metal ions (na+, k+, rb+) tightly bound to g-quadruplex dna are actually "nmr visible" in solution (wong, a.; ida, r.; wu, g. biochem. biophys. res. commun. 2005, 337, 363). here solution and solid-state nmr methods are developed for studying ion binding to the classic g-quadruplex structures formed by th ... | 2008 | 18293981 |
| the effectiveness of somatic embryogenesis in eliminating the cocoa swollen shoot virus from infected cocoa trees. | investigations were undertaken on the use of somatic embryogenesis to generate cocoa swollen shoot virus (cssv) disease free clonal propagules from infected trees. polymerase chain reaction (pcr) capillary electrophoresis revealed the presence of cssv in all the callus tissues induced from the cssv-infected amelonado cocoa trees (t1, t2 and t4). the virus was transmitted to primary somatic embryos induced from the infected callus tissues at the rate of 10 (19%), 18 (14%) and 16 (15%) for t1, t2 ... | 2008 | 18294704 |
| long-term outcome of 495 tnm stage i or ii patients with differentiated thyroid carcinoma followed up with neck ultrasonography and thyroglobulin measurements on t4 treatment. | recent guidelines for surveillance of patients with differentiated thyroid carcinoma emphasize tsh-stimulated serum thyroglobulin (tg) measurements and neck ultrasonographies (us) over tg measurements on t(4) and diagnostic whole body scans (dxwbs). we evaluated the safety and efficacy of a surveillance paradigm comprising yearly t(4)-suppressed tg measurements and neck us every second year, with an increase in tg to a detectable level being a prompt indication for dxwbs. | 2008 | 18284635 |
| triiodothyronine levels in athyreotic individuals during levothyroxine therapy. | thyroidal production of triiodothyronine (t3) is absent in athyreotic patients, leading to the suggestion that t3 deficiency may be unavoidable during levothyroxine (lt4) therapy. however, trials evaluating therapy with combined lt4 and t3 have failed to demonstrate any consistent advantage of combination therapy. | 2008 | 18285588 |
| thyrotoxic periodic paralysis. | a young man of 30 yrs got himself admitted in bangabandhu sheikh mujib medical university (bsmmu) hospital, dhaka, bangladesh with the complaints of suddenly developed weakness in his all four limbs. he had features of hyperthyroidism and he gave the history of similar attacks of weakness in his all four limbs in the previous months. his potassium was in the lower part of the normal range and his t4 and t3 were elevated but tsh was markedly low. he was diagnosed as a case of thyrotoxic periodic ... | 2008 | 18285742 |
| identification of acanthamoeba genotype t4 and paravahlkampfia sp. from two clinical samples. | in this study, two free-living amoebae strains, acanthamoeba genotype t4 and paravahlkampfia sp., which were isolated from keratitis cases are presented. while the acanthamoeba strain was isolated as a single agent, the paravahlkampfia strain was found together with herpes simplex virus. neither of the patients were contact lens wearers, but they did have a history of minor corneal trauma. amoebae were detected on non-nutrient agar covered with escherichia coli. based on pcr-amplified 18s rrna-g ... | 2008 | 18287307 |
| clinicopathological significance of cyclooxygenase-2 expression in hypopharyngeal squamous cell carcinoma. | the purpose of this study was to determine the expression of cyclooxygenase-2 (cox-2) in normal epithelium, dysplasia and squamous cell carcinoma of the hypopharynx and to investigate associations with clinicopathological factors and survival. seventy-five patients with hypopharyngeal squamous cell carcinomas (hpscc) who underwent surgical treatment at the department of otolaryngology, osaka medical center for cancer and cardiovascular diseases, were investigated. cox-2 expression was determined ... | 2008 | 18288396 |
| decreased expression of runx3 is correlated with tumor progression and poor prognosis in patients with esophageal squamous cell carcinoma. | runt-related transcription factor 3 (runx3) has been reported to be a candidate tumor suppressor gene in gastric cancer. however, in esophageal cancer, the role of runx3 has not been studied. the expression of runx3 mrna was quantified by real-time reverse transcription polymerase chain reaction using taq man pcr in 15 esophageal cancer cell lines (te1-15) and 70 esophageal squamous cell carcinoma (escc) specimens and their paired normal esophageal mucosa. the data were analyzed with reference t ... | 2008 | 18288406 |
| anatomy of thoracic splanchnic nerves for surgical resection. | thoracic splanchnic nerves conduct pain sensation from the abdominal organs around the celiac ganglion. splanchnicectomy is the procedure used mainly for the control of intractable visceral pain. forty-six human posterior thoracic walls were dissected. the formation pattern, course, and incidence of communication of the thoracic splanchnic nerves were investigated. the greater splanchnic nerves (gsns) were formed by nerve branches from the t4-t11 thoracic sympathetic ganglia and the most common ... | 2008 | 18288763 |
| metabolic effects of thyroid hormone derivatives. | the processes and pathways mediating the intermediary metabolism of carbohydrates, lipids, and proteins are all affected by thyroid hormones (ths) in almost all tissues. particular attention has been devoted by scientists to the effects of ths on lipid metabolism. among others, effects related to cholesterol, lipid handling, and cardiac performance have been the subject of study. many reports are present in the literature concerning the calorigenic effect of ths, with most of them aimed at ident ... | 2008 | 18279024 |
| [value of multislice spiral ct in preoperative staging of rectal carcinoma]. | preoperative staging is important for optimal therapy planning and prognosis prediction of rectal carcinoma. the role of conventional computed tomography (ct) in preoperative staging of rectal carcinoma is controversial. this study was to evaluate the value of multislice spiral computed tomography (msct) in preoperative staging of rectal carcinoma. | 2008 | 18279621 |
| thyroid gland development and defects. | during the functional ontogenesis of the thyroid gland an increasing number of transcription factors play fundamental roles in thyroid-cell differentiation, maintenance of the differentiated state, and thyroid-cell proliferation. the early growth and development of the fetal thyroid appears to be generally independent of thyroid-stimulating hormone (tsh). tsh and thyroxine (t4) levels increase from the 12th week of gestation until delivery, whereas triiodothyronine (t3) levels remain relatively ... | 2008 | 18279780 |
| postoperative stability after sagittal split ramus osteotomies for a mandibular setback with monocortical plate fixation or bicortical screw fixation. | this comparative study was performed to analyze mandibular stability after bilateral sagittal split ramus osteotomies for a mandibular setback with a monocortical plate fixation or bicortical screw fixation. | 2008 | 18280376 |
| oral squamous cell carcinoma margin discrepancy after resection and pathologic processing. | resecting oral squamous cell carcinoma (scc) with an appropriate margin of uninvolved tissue is critical in preventing local recurrence and making the decision regarding postoperative radiation therapy. this task can be difficult due to the discrepancy between margins measured intraoperatively and those measured microscopically by the pathologist after specimen processing. the goal of this study is to quantify and compare the amount of margin discrepancy observed based on tumor location and stag ... | 2008 | 18280387 |
| non-genomic actions of thyroid hormone in brain development. | thyroid hormone (th) is essential for neuronal migration and synaptogenesis in the developing brain. assembly of neuronal circuits depends on guidance cues provided by the extracellular matrix. these cues are interpreted by the migrating neuron and its growing neurites through transmembrane signaling proteins anchored in place by the actin cytoskeleton. one of the best examples of a non-genomic action of thyroid hormone is its dynamic regulation of the number and quantity of actin fibers in astr ... | 2008 | 18280526 |
| phage t4 segb protein is a homing endonuclease required for the preferred inheritance of t4 trna gene region occurring in co-infection with a related phage. | homing endonucleases initiate nonreciprocal transfer of dna segments containing their own genes and the flanking sequences by cleaving the recipient dna. bacteriophage t4 segb gene, which is located in a cluster of trna genes, encodes a protein of unknown function, homologous to homing endonucleases of the giy-yig family. we demonstrate that segb protein is a site-specific endonuclease, which produces mostly 3' 2-nt protruding ends at its dna cleavage site. analysis of segb cleavage sites sugges ... | 2008 | 18281701 |
| prostate cancer in renal transplant recipients. | we conducted a retrospective multi-centre study to determine the characteristics of prostate cancer in renal transplant recipients (rtr) and to analyse the relation with immunosuppressive maintenance therapies. | 2008 | 18283085 |
| intra-arterial chemoradiotherapy for locally advanced oral cavity cancer: analysis of therapeutic results in 134 cases. | the objective of this study was to investigate the therapeutic results of arterial injection therapy via the superficial temporal artery for 134 cases of stages iii and iv (m0) oral cavity cancer retrospectively, and to clarify the prognostic factors. we administered intra-arterial chemoradiotherapy by continuous infusion of carboplatin in 65 cases from january 1993 to july 2002. systemic chemotherapy was performed on 26 cases at the same time. we administered intra-arterial chemoradiotherapy by ... | 2008 | 18283309 |
| rapid isolation and identification of bacteriophage t4-encoded modifications of escherichia coli rna polymerase: a generic method to study bacteriophage/host interactions. | bacteriophages are bacterial viruses that infect bacterial cells, and they have developed ingenious mechanisms to modify the bacterial rna polymerase. using a rapid, specific, single-step affinity isolation procedure to purify escherichia coli rna polymerase from bacteriophage t4-infected cells, we have identified bacteriophage t4-dependent modifications of the host rna polymerase. we suggest that this methodology is broadly applicable for the identification of bacteriophage-dependent alteration ... | 2008 | 18271525 |
| atomic force microscopy reveals parallel mechanical unfolding pathways of t4 lysozyme: evidence for a kinetic partitioning mechanism. | kinetic partitioning is predicted to be a general mechanism for proteins to fold into their well defined native three-dimensional structure from unfolded states following multiple folding pathways. however, experimental evidence supporting this mechanism is still limited. by using single-molecule atomic force microscopy, here we report experimental evidence supporting the kinetic partitioning mechanism for mechanical unfolding of t4 lysozyme, a small protein composed of two subdomains. we observ ... | 2008 | 18272500 |
| endocrine factors and ovarian follicles are influenced by body condition and somatotropin in postpartum beef cows. | multiparous beef (1/4 to 3/8 bos indicus; n = 99) cows were managed to achieve low (bcs = 4.3 +/- 0.1; n = 50) or moderate (bcs = 6.1 +/- 0.1; n = 49) body condition (bc) to determine the influence of bovine (b) st on the number of follicles, diameter of largest follicle, and serum concentrations of igf-i, triiodothy-ronine (t3), thyroxine (t4), and prolactin. beginning 32 d postpartum, cows within each bc were assigned randomly to treatment with or without bst. non-bst-treated cows received no ... | 2008 | 18272855 |
| performance, behavior, and welfare of friesian heifers housed in pens with two, four, and eight individuals per concentrate feeding place. | the objective of the present study was to examine the effects of increasing the number of heifers per concentrate feeding place on performance, behavior, welfare indicators, and ruminal fermentation of feedlot heifers. seventy-two friesian heifers were used in a factorial arrangement, with 3 treatments and 3 blocks of similar bw. treatments consisted of 2 (t2), 4 (t4), or 8 (t8) heifers per each place in the concentrate feeder (8 heifers/pen). concentrate and straw were fed at 0830 h in individu ... | 2008 | 18272856 |
| café-au-lait macules and pediatric malignancy caused by biallelic mutations in the dna mismatch repair (mmr) gene pms2. | a 14-year-old male presented with a t4 sigmoid adenocarcinoma, <10 colonic adenomas and multiple café-au-lait macules. family history was not suggestive of a dominant hereditary form of colorectal cancer. evaluation of the tumor revealed abnormal immunohistochemical staining of the pms2 protein and high frequency microsatellite instability. germline analysis identified biallelic pms2 missense mutations. a new cancer syndrome caused by biallelic mutations in the mismatch repair genes, including p ... | 2008 | 18273873 |
| surveillance for hepatocellular carcinoma in patients with cirrhosis improves outcome. | liver transplantation has become an effective treatment for cirrhotic patients with early-stage hepatocellular carcinoma. we hypothesized that the quality of surveillance for hepatocellular carcinoma influences prognosis by affecting access to liver transplantation. | 2008 | 18261500 |
| two-generation reproductive toxicity study of the flame retardant hexabromocyclododecane in rats. | male and female rats were fed a diet containing flame retardant hexabromocyclododecane (hbcd) at 0, 150, 1500 or 15,000 ppm throughout the study beginning at the onset of a 10-week pre-mating period and continuing through the mating, gestation and lactation periods for two generations. the mean daily intakes of hbcd during the whole period of administration were 10.2, 101 and 1008 mg/kg bw in f0 males, 14.0, 141 and 1363 mg/kg bw in f0 females, 11.4, 115 and 1142 mg/kg bw in f1 males, and 14.3, ... | 2008 | 18262388 |
| effects of various antidepressants on serum thyroid hormone levels in patients with major depressive disorder. | a total of 62 patients with major depressive disorder were analyzed in the study. patients were evaluated for 11 weeks in an open label design to investigate the differential effects of reboxetine, sertraline and venlafaxine on thyroid hormones. serum thyrotrophin (tsh), thyroxine (t4) and free (f)t4 levels were measured before and after treatment. all groups showed significant improvement in ham-d scores. tsh level significantly reduced and t4 level significantly increased in the reboxetine gro ... | 2008 | 18262705 |
| dissecting the matrilineal components of tongjiang cattle from southwest china. | tongjiang cattle are a local cattle population of sichuan province, china, numbering approximately half a million in 2005. they have long been grouped into the bashan breed, although they have a unique breeding history and phenotypic characteristics, as well as a restricted geographic distribution. morphologically, they can be divided into two groups based on the basic coat color (black and russet). in order to dissect the matrilineal components of tongjiang cattle and to compare the body size t ... | 2008 | 18246422 |
| pten expression is a strong predictor of survival in mesothelioma patients. | malignant pleural mesothelioma (mpm) is a highly aggressive tumour with poor prognosis and limited response to therapy. mpm is characterised by complex chromosomal aberrations, including chromosome 10 losses. the tumour suppressor gene phosphatase and tensin homologue deleted from chromosome 10 (pten) located on chromosome 10q23 plays an important role in different cancer, but its relevance for mpm is unclear. | 2008 | 18248818 |
| non-small cell lung cancer with ipsilateral pulmonary metastases: prognosis analysis and staging assessment. | although designated as t4 or m1 in the current tnm classification system revised in 1997, non-small cell lung cancer with ipsilateral pulmonary metastases is treated as a locally advanced disease and reported survival rates are relatively good. we intended to analyze the prognosis of ipsilateral pulmonary metastases and validate current tnm classification system. | 2008 | 18249000 |
| primary tumor volume of nasopharyngeal carcinoma: significance for survival. | to elucidate the effect of primary tumor volume (ptv) on treatment outcomes in patients with nasopharyngeal carcinoma (npc) who were treated with radiotherapy or concurrent chemoradiotherapy. the tnm staging system developed by american joint committee of cancer (ajcc) is universally used and accepted but its prediction of prognosis in npc receives a lot of challenge. primary tumor volume had been reported to have close relationship with prognosis of head and neck cancer. we may predict prognosi ... | 2008 | 18249078 |
| long-term changes of the upper lip position relative to the incisal edge. | one result of postadolescent facial growth is elongation of the upper lip and subsequent decrease of incisal display on smiling. the aim of this study was to evaluate the long-term change of upper lip position relative to the incisal edge. | 2008 | 18249286 |
| follicular histotypes of oncocytic thyroid carcinomas do not carry mutations of the braf hot-spot. | the braf v600e mutation is the most prevalent genetic aberration in papillary thyroid carcinomas (ptcs), and it is found exclusively in ret/ptc-negative tumors. in oncocytic (hürthle cell, oxyphilic) thyroid tumors, the presence of ret/ptc rearrangements is associated with either the conventional papillary histotype or the "solid" hürthle cell tumors, whereas all predominantly follicular oncocytic carcinomas do not harbor ret/ptc chimeras. although 12% of tumors of the follicular variant of ptc ... | 2008 | 18235983 |
| muscle study in experimental scoliosis in rabbits with costotransversectomy: evidence of ischemic process. | scoliosis involves the central nervous system diseases, ligaments, articulations and skeletal muscles, but there is no consensus on its pathogeny and progression of muscle abnormalities. in this study, we investigate the morphologic changes in the muscle of rabbit submitted to experimental scoliosis, with special emphasis on abnormalities related to blood supply. we studied 26 rabbits subjected to costotransversectomy by pulling out six transverse processes at thoracic level and six rabbits were ... | 2008 | 18210168 |
| association of first-trimester thyroid function test values with thyroperoxidase antibody status, smoking, and multivitamin use. | to determine first-trimester thyroid function values and associations with thyroperoxidase antibody (tpo-ab) status, smoking, emesis, and iodine-containing multivitamin use. | 2008 | 18238739 |
| exacerbation of underlying hypothyroidism caused by proteinuria and induction of urinary thyroxine loss: case report and subsequent investigation. | to describe a patient with excess urinary thyroxine (t4) excretion and worsening of preexisting hypothyroidism in the setting of nephrotic syndrome and to determine whether excess urinary t4 excretion is present in other patients with proteinuria. | 2008 | 18238748 |
| comparison of a new neuromuscular transmission monitor compressomyograph with mechanomyograph. | we developed a new neuromuscular transmission monitor, the compressomyograph (cmg, european patent number: ep 06018557.6, us patent number: us 60/824.541). this is the first preliminary report comparing neuromuscular block monitored by cmg and the relaxometer mechanomyograph (mmg). | 2008 | 18238840 |
| depth of tumor invasion in locally advanced rectal cancer correlates with patients' prognosis: the usefulness of elastic stain for its measurement. | the relationship between the prognosis and the extent of colorectal carcinoma (crc) is still unclear. as a simple parameter of the local invasion of crc, we assessed the extent of tumor invasion beyond the outer border of the muscularis propria (mp). | 2008 | 18239867 |
| compliance with melanoma treatment guidelines in a community teaching hospital: time trends and other variables. | variation in the surgical treatment of melanoma occurs despite efforts to standardize care. this may lead to morbidity, inaccurate staging, and poor outcomes, or it may be cost ineffective. the purpose of our study was to evaluate our institutional compliance with national comprehensive cancer network (nccn) melanoma treatment guidelines. | 2008 | 18239975 |
| 5-ht(7) receptors in the modulation of cognitive processes. | the abundance of serotonin (5-ht) in the central nervous system can explain its role in the regulation of various functions, such as sleep, feeding, sexuality, emotional status, and pain. in addition, 5-ht localized in "cognitive pathways" with hippocampus and frontal cortex as the main target structures, is involved in learning and memory processes. recent studies led to the discovery of various types and subtypes of receptors, differentially associated to cognitive mechanisms. abundant data av ... | 2008 | 18243350 |
| pyruvate kinase isoenzyme m2 is not of diagnostic relevance as a marker for oral cancer. | increased aerobic glycolysis is one of the most common abnormalities occurring in the metabolism of tumour cells with pyruvate kinase as one of the key glycolytic enzymes. the dimeric form of m2-pyruvate kinase, found predominantly in tumour cells, is designated as tumour m2-pyruvate kinase (tum2-pk). the aim of the present, prospective study was to evaluate the diagnostic relevance of tum2-pk in detecting oral squamous cell carcinoma (oscc). | 2008 | 18243718 |
| templated mutagenesis in bacteriophage t4 involving imperfect direct or indirect sequence repeats. | some mutations arise in association with a potential sequence donor that consists of an imperfect direct or reverse repeat. many such mutations are complex; that is, they consist of multiple close sequence changes. current models posit that the primer terminus of a replicating dna molecule dissociates, reanneals with an ectopic template, extends briefly, and then returns to the cognate template, bringing with it a locally different sequence; alternatively, a hairpin structure may form the mutati ... | 2008 | 18245334 |
| development of a multiplex rna urine test for the detection and stratification of transitional cell carcinoma of the bladder. | new markers that enable the percentage of transitional cell carcinomas (tcc) of the bladder that are diagnosed before invasion of the bladder muscle layers to be increased would reduce the morbidity and mortality associated with this disease. the purpose of this study was to develop a simple, accurate urine test based on mrna markers and simple gene signatures that (a) could detect tcc before muscle invasion while maintaining high specificity in patients with hematuria or urinary tract infection ... | 2008 | 18245534 |
| [endocrinology]. | treatment and follow-up of differenciated thyroid carcinoma and use of recombinant human tsh in the case of ablative radio-iodine treatment or thyroglobulin stimulation are discussed in the context of new international recommandations. subclinical thyroid disease and abnormal thyroid function tests during pregnancy are the other topics. treatment of subclinical hyperthyroidism is recommended when tsh is below 0.1 mu/l because of cardiac and bone complication while a substitutive thyroid hormone ... | 2008 | 18251209 |
| nickel, chromium and iron levels in the saliva of patients with simulated fixed orthodontic appliances. | to assess the in vivo release of nickel, chromium, and iron ions into saliva by different metallic brackets. | 2008 | 18251615 |
| ingestion and inactivation of bacteriophages by tetrahymena. | abiotic factors are thought to be primarily responsible for the loss of bacteriophages from the environment, but ingestion of phages by heterotrophs may also play a role in their elimination. tetrahymena thermophila has been shown to ingest and inactivate bacteriophage t4 in co-incubation experiments. in this study, other tetrahymena species were co-incubated with t4 with similar results. in addition, t. thermophila was shown to inactivate phages t5 and lambda in co-incubations. several approach ... | 2008 | 18251802 |
| transthyretin levels are not related to apgar score in low birth weight and very low birth weight infants. | previous studies have reported an increased incidence of thyroid dysfunction in premature/low birth weight infants. the cord blood concentrations of transthyretin (ttr), a thyroid hormone binding protein, have also been found to be decreased in preterm infants. while thyroid hormone concentrations are decreased in sick infants, it is not known if physical condition influences ttr levels. serial concentrations of ttr following birth have not previously been reported. | 2008 | 18252270 |
| endocrine effects of tetrabromobisphenol-a (tbbpa) in wistar rats as tested in a one-generation reproduction study and a subacute toxicity study. | endocrine effects of the brominated flame retardant tetrabromobisphenol-a (tbbpa) were studied in a one-generation reproduction assay in wistar rats via repeated dietary exposure, applying eight dose groups at 0-3-10-30-100-300-1,000-3,000 mg/kg body weight/day (mkd). this design enables dose-response analysis and calculation of benchmark doses (bmdl). this reproduction study was preceded by a 28-day repeat dose subacute toxicity study, at 0-30-100-300 mkd. major effects in the reproduction stud ... | 2008 | 18255212 |
| radical prostatectomy in men aged >or=70 years: effect of age on upgrading, upstaging, and the accuracy of a preoperative nomogram. | to determine the effect of age on clinicopathological features, the accuracy of the preoperative nomogram, and survival after radical retropubic prostatectomy (rrp), as there are limited data on elderly men undergoing rrp. | 2008 | 18257855 |
| is sympathectomy at t4 level better than at t3 level for treating palmar hyperhidrosis? | we compared the results from a video-assisted thoracoscopic sympathectomy (vts) at the t4 denervation level with those from a vts at the t3 level for the treatment of palmar hyperhydrosis (ph). | 2008 | 18266585 |
| the impact of spontaneous tumour perforation on outcome following colon cancer surgery. | the impact of spontaneous tumour perforation on survival following surgery for colon cancer is unclear. this study compares survival outcomes for patients with perforated colonic cancer with stage-matched nonperforated cancer. | 2008 | 18266887 |
| effect of thyroid hormone concentration on the transcriptional response underlying induced metamorphosis in the mexican axolotl (ambystoma). | thyroid hormones (th) induce gene expression programs that orchestrate amphibian metamorphosis. in contrast to anurans, many salamanders do not undergo metamorphosis in nature. however, they can be induced to undergo metamorphosis via exposure to thyroxine (t4). we induced metamorphosis in juvenile mexican axolotls (ambystoma mexicanum) using 5 and 50 nm t4, collected epidermal tissue from the head at four time points (days 0, 2, 12, 28), and used microarray analysis to quantify mrna abundances. | 2008 | 18267027 |
| regionalisation of the muscle fascicle architecture in the equine longissimus dorsi muscle. | the longissimus dorsi is the largest muscle in the equine back and plays an important role in locomotor ability and performance in the horse. in vivo studies suggest that the mechanical function varies between different muscle segments, in part determined by anatomy. it is possible therefore that variations in function reflect variations in the anatomy of the longissimus dorsi along its length. | 2008 | 18267885 |
| the concerted action of lactoferrin and bacteriophages in the clearance of bacteria in sublethally infected mice. | both lactoferrin (lf) and bacteriophages are potent antibacterial agents. lf is contained in the secretory fluids of mammals and bacteriophages are specific bacterial viruses. | 2008 | 18268472 |
| ovarian hyperstimulation syndrome caused by an fsh-secreting pituitary adenoma. | a 40-year-old woman presented with galactorrhea and oligomenorrhea. she had a history of multiple ovarian cysts and pelvic pain. | 2008 | 18268519 |