Publications

in vitro bacteriostatic and bactericidal activities of 7 cephalosporin antibiotics on haemophilus influenzae.	a total of 30 recently isolated strains of haemophilus influenzae were tested for in vitro susceptibility to seven cephalosporins. in order of bacteriostatic effectiveness, the in vitro activity of the antibiotics studied was: cephapirin (median mic = 0.78 mcg/ml), cephalothin (median mic = 1.56 mcg/ml), cefazolin (median mic: 1.56 mcg/ml), cephaloridine (median mic = 3.12 mcg/ml), cefoxitin (median mic = 3.12 mcg/ml), cephradine (median mic = 12.5 mcg/ml) and cephalexin (median mic = 25 mcg/ml) ...	1975	1081973
ampicillin-resistant haemophilus influenzae pneumonia and empyema in an infant.	ampicillin-resistant haemophilus influenzae type b was isolated from the pleural fluid of a 15-month-old infant with pneumonia and empyema. the patient was cured when chloramphenicol treatment was substituted for ampicillin.	1975	1081984
blockade by morphine of acetylcholine release from the caudate nucleus in the mid-pontine pretrigeminal cat.		1975	1111819
an electron microscopic analysis of rubrospinal tract termination in the spinal cord of the cat.		1975	1111850
new evidence for an intermediate polymer of glucose in cellulose biosynthesis by acetobacter xylinum.	the results of sucrose-density-gradient centrifugation of a cell-free particulate enzyme system from acetobacter xylinum which was incubated with uridine diphosphoglucose indicate that there is a polymeric intermediate in the biosynthesis of cellulose. this intermediate has the properties of an oligomer of glucose, is normally attached to the heaviest particle of the suspension, but, when released by hydrolysis, is preferentially adsorbed to fragments of preformed cellulose. it may form short se ...	1975	1111860
renal hemodynamics and medullary osmolal gradient in ischemic acute renal failure in rabbits.	the effects of 2 hours of renal artery occlusion were studied in previously uninephrectomized rabbits. oliguric renal failure by arterial clamping was produced. renal blood flow was maintained during observation periods, except for an early decrease in outer cortical blood flow without change elsewhere. during the oliguric stage medullary osmolality was markedly diminished, concomitantly with reduced (u/p)osm. cin, epah and sodium reabsorption were decreased, accompanied by tubular necrosis and ...	1975	1113448
letter: reactions of cartilage.		1975	1113834
[clinical signs and biochemical changes in the blood in anaplasmosis].		1975	1114674
the uptake of fructose by pseudomonas putida.	fructose transport was not apparently affected in a number of pseudomonas putida strains with deranged activity of a common glucose-gluconate uptake system, indicating the existence of an independent fructose uptake system. fructose uptake by glucose-gluconate uptake mutants was induced by fructose and obeyed saturation kinetics (apparent km equal 0.3 mm). the fructose uptake system serves to transport glucose in addition to fructose. the entry of fructose into p.putida cells appears to be media ...	1975	1115560
action of the mycotoxin of fusarium sporotrichiella v. sporotrichioides on lysosomal membranes.	the effect of the mycotoxin of fusarium sporotrichiella v. sporotrichioides (sporofusarin) was studied in vitro on the total and nonsedimenting activity of eight lysosomal enzymes: acid ribonuclease, aryl sulfatases a and b, beta-glucuronidase, alpha- and beta-galactosidases, beta-glucosidase, beta-acetylglucosaminidase, and alpha-mannosidase. incubation of a suspension of rat liver lysosomes with an aqueous solution of sporofusarin led to inhibition of the total activity of the membrane-bound l ...	1975	1115854
the normal human esophageal mucosa: a histological reappraisal.	in 19 asymptomatic subjects, a total of 95 mucosal suction biopsies were taken from multiple sites in the distal 10 cm of esophagus. the biopsies were examined for evidence of basal cell hyperplasia and elongated dermal papillae, features considered to be histological consequences of gastroesophageal reflux. fifty-seven per cent of the biopsies in the distal 2.5 cm of the esophagus and 19% of the biopsies above 2.5 cm exhibited these histological features.	1975	1116665
fine structure of the endogenous stages of eimeria labbeana. i. the first generation merozoites.	the fine structure of the 1st generation merozoites of eimeria labbeana from the ileal mucosa of artificially infected pigeons (columba livia) was investigated and described. the 1st generation merozoites which appeared between 36-48 hr after infection averaged 4.4 times 2.1 mum in size. the 3-membraned pellicle was irregular in texture and harbored a single micropore, and many micropore-like invaginations. closely apposed to the inner pellicular membrane were seen 22 microtubules, each 22-25 ...	1975	1117437
atp and muscle enzyme efflux after physical exertion.		1975	1120368
fiber-optic video study of the post-laryngectomized voice.	simultaneous video-fluoroscopy and fiber-optic video laryngoscopy was carried out on a series of eight laryngectomees. previous concepts supported by an earlier report1 indicated that the folds of the rebuilt cricopharyngeal sphincter were seen to represent the primary source of sound vibration for voice production. fold vibration was envisioned as an essential for sound production. present findings present a challenge to the older concept. the fluoroscopic studies showed a considerable variatio ...	1975	1121236
extracellular enzyme system utilized by the fungus sporotrichum pulverulentum (chrysosporium lignorum) for the breakdown of cellulose. 2. activities of the five endo-1,4-beta-glucanases towards carboxymethylcellulose.	a complementary discussion is given of an earlier presented theory for viscometric determination of enzymic activity towards polymer substrates. five different, purified endo-1,4-beta-glucanases from the fungus sporotrichum pulverulentum have been characterised with respect to their molecular activities(am) and michaelis-menten constants (km). the errors in the am and km values are discussed. the am value seems to be more valuable as a distinguishing parameter than the km value.	1975	1122913
[a kin with a "silent" pseudocholinesterase gene (author's transl)].	after injection of short acting muscle relaxant suxamethonium on a 5-year-old boy during bronchography he was suffering from prolonged apnoe. although using acetylthiocholin, butyrylthiocholin and benzoylcholin for tests we were not able to detect any activity of pseudocholinesterase in the patient's serum, since there was no evidence of hepatic disease or hypoproteinemia, we supposed a genetically caused deficiency of serumcholinesterase. examinations done on 18 members of this kin showed a com ...	1975	1124584
the diagnostic value of certain alkaline phosphatase isoenzyme patterns in human serum, fractions obtained by polyacrylamide disc electrophoresis.	over 2500 pathological sera were analysed to determine alkaline phosphatase (ec 3.1.3.1) isoenzyme levels. 3% of these sera showed two or more narrow isoenzyme bands with a lower electrophoretic mobility on polyacrylamide than that of the intestine type of alkaline phosphatase and higher than that of the bile type of alkaline phosphatase (the extra-bands group). this latter group showed significantly more intestine-tupe alkaline phosphatase than a control group of 240 sera lacking extra serum ba ...	1975	1126037
studies on filariasis. iv. the rate of escape of the third-stage larvae of brugia pahangi from the mouthpart of aedes togoi during the blood meal.	the rate of escape of the third-stage larvae of brugia pahangi from aedes togoi which were allowed to probe on a cat and a mouse at time intervals of 5, 10, 20, 30 and 60 seconds was studied. the rate of escape of third-stage larvae at all time intervals was greater during probing on the cat than on the mouse, and was in a logarithmic linear relation to the length of probing time by the mosquito host. the greatest loss (91.35%) of third-stage larvae was in mosquitoes which fed on a cat until ful ...	1975	1127218
[a case of empyema due to an anaerobic bacteria, peptostreptococcus].		1975	1127834
deep hypothermia and its effect on the 24-hour clock of rats and hamsters.	intensive hypothermia in rats and hamsters whose breathing and heartbeat had stopped for 1-4 hours was used as a setting in which to study the 24-hour biological clock. pre- and post-hypothermia analyses depended on behavior wherein spontaneous running activity in revolving drums was used as a "hand" of the biological clock. hypothermia had various effects. in some cases the clock was temporaily stopped, i.e., reset. in others it was simply slowed. some clocks were both reset and slowed. others ...	1975	1127837
[use of a freeze-drief culture of leuconostoc mesenteroides for the synthesis of dextran].	the influence of a prolonged storage of the freeze-dried culture leuconostoc mesenteroides strain sf-4 on its capacity for the dextrane synthesis has been studied. the culture has maintained its normal viability for 12 years (the observation time) without changes in the cell morphology and capacity for the dextrane synthesis. the structure of dextrane synthesized by the revived culture l. mesenteroides has been similar to that of dextrane synthesized by the culture l. mesenteroides preserved via ...	1975	1129227
embryo transfer: an experimental tool with practical applications.		1975	1140492
inhibition of electromyographic activity in human triceps surae muscles during sinusoidal rotation of the foot.	torque and electromyographic (emg) responses to sinusoidal rotations of the foot were measured. the frequency range of the movements was 0.5 hz to 15 hz at amplitudes ranging between 1 and 10 degrees. at frequencies above 7 hz, the emg activity did not follow individual foot rotation cycles. the emg activity was inhibited whenever the peak torque was large with respect to the first cycle peak torque. dantrolene sodium reduced the torque developed in triceps surae, allowing the emg activity to f ...	1975	1141920
isolation of dna polymerase gamma from an adenovirus 2 dna replication complex.	the major dna polymerase in a nuclear membrane complex that is capable of synthesizing viral dna sequences in vitro has been purified about 900-fold from adenovirus 2-infected kb cells. the enzyme was characterized as belonging to the class of mammalian dna polymerases (dna polymerase gamma) that can utilize poly(a) with oligo(dt) as template primer.	1975	1142477
[editorial: human biological aspects of nuclear power stations in denmark].		1975	1145784
the displacing effect of a fatty acid on the binding of diazepam to human serum albumin.		1975	1148025
acetylcholine receptors in normal and denervated rat diaphragm muscle. ii. comparison of junctional and extrajunctional receptors.	acetylcholine (ach) receptors have been purified separately from normal rat diaphragm muscle (junctional receptors) and from extrajunctional regions of denervated diaphragm (extrajunctional receptors) in order to compare their properties. the toxin-receptor complexes of the two receptors were indistinguishable by gel filtration and by zone sedimentation in sucrose gradients, and showed identical precipitation curves with rabbit antiserum to the eel ach receptor. both toxin-receptor complexes bin ...	1975	1148161
monoamine oxidase inhibiting activity of a series of (+/-)-4-methoxy-beta-hydroxyphenethylamines.	the synthesis and selected pharmacological testing of (+/-)-4-methoxy-beta-hydroxyphenethylamine [1-(4-methoxyphenyl)-2-aminoethanol] and its n-methylated derivatives are presented. members of this series were found to exert partial prevention of reserpine-induced hypothermia in mice and to inhibit monoamine oxidase in warburg studies. activity was essentially dose dependent. the secondary amine was the most active member of the series. the tertiary amine was least active, and the primary amine ...	1975	1151725
the cardiac pharmacology of tolbutamide.	recent clinical studies have suggested an association of tolbutamide therapy with an increased incidence of cardiovascular deaths. due to the paucity of information concerning the acute cardiac actions of tolbutamide, the effects of this agent upon cardiac contractility and automaticity were examined under in vivo and in vitro conditions in rabbit, cat and dog heart muscle preparations. tolbutamide (10(-6) to 3 x 10(-3) m) produced a biphasic inotropic response with a peak positive inotropic res ...	1975	1151754
the transport of gentamicin in the choroid plexus and cerebrospinal fluid.	gentamicin often attains inadequate therapeutic levels in cerebrospinal fluid (csf). in the present study, the possibility that gentamicin might be transported from csf to blood by a mechanism in the choroid plexus was investigated. rabbit choroid plexuses were incubated 15 to 120 minutes in artificial csf containing 14c-gentamicin and 3h-inulin. the choroid plexuses accumulated gentamicin linearly up to 120 minutes where a tissue/medium ratio of 5.4 was attained. uptake of gentamicin was inhibi ...	1975	1151757
the antiarrhythmic and hemodynamic actions of alpha, alpha-dimethyl-4-(alpha, alpha, beta, beta-tetrafluorophenethyl) benzylamine (mk-251).	alpha,alpha-dimethyl-4-(alpha,alpha,beta,beta-tetrafluorophenethyl)benzylamine (mk-251) has been found to prevent certain types of experimentally induced ventricular arrhythmias and at maximally effective doses possesses substantial hemodynamic safety in contrast to standard antiarrhythmic agents. mk-251 prevented or modified ventricular arrhythmias produced by injection of tetrafluorohexachlorobutane into the coronary artery of dogs and baboons. in dogs, the dose estimated to prevent 80% of the ...	1975	1151767
responses of inner and outer muscle of the sheep carotid artery to injury.	1. direct injury to the smooth muscle of the sheep carotid artery in vivo caused large, persistent and sharply limited annular contraction, even with tetrodotoxin 10(-5)m present to block nerves. 2. surcose gap records from artery strips showed that mechanical injury caused slow, prolonged depolarization of the smooth muscle that spread for a few millimetres in a circular direction in relation to the intact artery wall with an apparent space constant of 1-26--3.49 mm. in the longitudinal directi ...	1975	1151781
the effect of duodenal infusion on the electromyogram of gastric muscle during activation and inhibition of gastric emptying.	1. when the abomasum of the conscious calf is partially distended, rhythmic motility can readily be recorded from the e.m.g. of the smooth muscle of the fundus (body) and antrum. 2. in gastric evacuation rhythmic contractions of the antrum are reinforced by both rhythmic and tonic fundic contractions. 3. the output volume of the stomach can be directly correlated with e.m.g. activity. 4. intragastric fluid is usually emptied in gushes coinciding with a strong contraction of the antrum but fluid ...	1975	1151789
proceedings: effects of histamine, 2-methylhistamine and 4-methylhistamine on blood pressure and vascular resistance in the cat.		1975	1151865
proceedings: the influences of hypercapnia and hypoxia on the activity recorded from intestinal sympathetic nerves in the rabbit with cut sinus nerves.		1975	1151889
the intracellular distribution of cathepsins and other acid hydrolases in mouse peritoneal macrophages.	acid hydrolases, among them cathepsins a, b, c, and d, and their intracellular distribution have been studied in mouse peritoneal macrophages, a model commonly used for the study of mononuclear phagocyte functions in host-parasite relationships and in the immune response. thioglycollate stimulated peritoneal macrophages showed high specific activities of acid hydrolases in compatison to liver and spleen. fractionation of these macrophages by differential and isopycnic sucrose density centrifugat ...	1975	1151946
[effect of an oxygen-vitamin complex on general and immunological reactivity of irradiated animals].		1975	1153721
femoral percutaneous catheterization in infants and small children for cerebral angiography.	an improved technique of selective cerebral angiography for infants and small chicken is described. the needle is inserted approximately 45 degrees to the skin in order to avoid subintimal placement of the tip. after good backflow is established, the guidewire is advanced to a position in the descending aorta. a no. 3 polyethylene catheter and 21-gauge scalp vein needle were most successful.	1975	1153751
prostaglandin-induced enhancement of the in vitro anamnestic response.	the ability of various prostaglandins (pgs) to affect the in vitro anamnestic immune response of keyhole limpet hemocyanin (klh)-primed rabbit popliteal lymph node cells was investigated. of the four pgs studied (pga1, pge2 and pgf2alpha), pge1 was found to have a stimulatory effect, whereas pga1, pge2 and pgf2alpha were ineffective in stimulating or inhibiting the in vitro anamnestic response. under the conditions studied, a 3.5-fold increase in antibody production was obtained in pge1-treated, ...	1975	1153806
doxycycline concentrations in lung tissue, bronchial wall, and bronchial secretions.	doxycycline levels were measured in 44 patients undergoing lung surgery; 44 determinations were made on serum, 37 on resected lung tissue, 11 on bronchial wall, and 8 on bronchial secretions. the concentrations in lung tissue were, with few exceptions, higher than the serum concentrations, while those in homogenized bronchial wall specimens were slightly lower than the serum readings. all these concentrations were on average considerably higher than the minimum inhibitory concentrations for the ...	1975	1157579
proceedings: increased vascular permeability as a causative factors in the development of cerebrovascular lesions in shr.		1975	1160176
dietary fats and properties of endoplasmic reticulum: i. dietary lipid induced changes in composition of microsomal membranes in liver and gastroduodenal mucosa of rat.	rats were fed for four weeks with different lipid diets to determine the effects on the endoplasmic reticulum membranes of the liver and on the postmitochondrial supernatant fraction of the gastroduodenal mucosa. the diets contained cholesterol, cacao butter, olive oil, and these in combination. the results showed that dietary lipids were able to modify the composition of the hepatic endoplasmic reticulum and, to a lesser extent, that of postmitochondrial fraction of gastroduodenal mucosa. cacao ...	1975	1160521
properties of enzymes. iv. non-specific superoxide dismutase activity of iron-porphyrin systems.		1975	1168569
culture of zollinger-ellison tumor cells.	we have successfully grown six zollinger-ellison tumors in vitro with use of a monlayer tissue culture technique. the initial gastrin concentration in the medium varied between 0 and 100 ng per ml. many cytoplasmic secretory granules were seen in the cells of one culture population. gastrin secretion was stimulated by the addition of fresh medium to the culture flasks. both the culture cells and the medium were found to contain primarily big gastrin (g-34) but smaller amounts of little gastrin ( ...	1975	1168604
[erythropoiesis in experimental acute uremia].		1975	1168610
utilization of ribonucleic acid and deoxyoligomer primers for polyadenylic acid synthesis by adenosine triphosphate: polynucleotidylexotransferase from maize.	the atp:polynucleotidylexotransferase isolated and purified from maize seedlings catalyzes the synthesis of polyadenylic acid by the sequential addition of 80 to 200 amp moieties from atp to the 3'-hydroxyl terminus of either ribo- or deoxyoligomers. copurification of the rna and dna-primed activities, identical metal cofactor and reaction requirements for either primer and identical heat inactivation curves with either primer strongly suggest that both primers are utilized by the same enzyme.	1975	1168636
twenty-four-hour prolactin profiles in normal and disease states: failure of thyroxine to modify prolactin secretion.	in order to assess the role of thyroid hormone on physiologically and pharmacologically induced prolactin (prl) secretion, serum prl concentrations were measured in 4 normal women and 4 women with various endocrinopathies before, and 4 to 6 days following, the ingestion of l-thyroxine (t4). a single 1.5 to 3.0 mg dose of oral t4 produced approximately a 2-fold increase in serum t4. exogenous t4 did not significantly alter the mean concentration, or the pattern of prl secretion during a 24-h inte ...	1975	1168655
long-term effects of vasectomy on pituitary-gonadal function in man.	plasma concentrations of testosterone (t), follicle stimulating hormone (fsh), and luteinizing hormone (lh) and percent binding of t to plasma protein (tb) were studied in 16 normal fertile men and in 81 men who had undergone vasectomy from 1 to 5 yr earlier. no significant difference from the control values to t = 582 plus or minus 39.5 (se) ng/100 ml; fsh = 15.09 plus or minus 2.18 (se) miu/ml; lh =10.03 plus or minus 1.13 (se) miu/ml and tb = 92.99 plus or minus 0.285 (se) % binding was detec ...	1975	1168657
polysaccharides as labels for antibodies in electron microscopy.	two polysaccharides, dextran 250 and dextran 70, were covalently linked to antibody molecules, antihuman immunoglobulin g and antihuman type o red blood cells. in electron microscope preparations exposed to lead citrate, polysaccharides, because they chelate lead, were quite dense. polysaccharides served as a tag for the antibody molecules. also, bacterial dextran 1355 was used to demonstrate antibody molecules on the surface of ascites tumor cells which are known to be producing a specific anti ...	1975	1168665
agarose beads as matrices for proteins in cytophotometric investigations of immunohistoperoxidase procedures;.	quantitative aspects of direct immunohistoperoxidase procedures were studied in a model system consisting of agarose beads to which antigens or antibodies had been coupled. it could be proven that the final amount of reaction product resulting from the histoperoxidase reaction with 3,3-diaminobenzidine-tetra hcl in a bead was linearly related to the volume of the beads and to the staining time. this implies that protein-coupled agarose beads are a suitable model for the study of stoichiometric a ...	1975	1168666
protein requirements of man: comparative nitrogen balance response within the submaintenance-to-maintenance range of intakes of wheat and beef proteins.	sixteen young male students participated in two studies designed to determine the nitrogen balance response to beef or stone-ground, whole wheat protein over the submaintenance-to-maintenance range of protein intake. the objective of the studies was to evaluate the relative capacities of these proteins to meet the minimum protein needs in young adult males. a modified latin-square design was used to allocate subjects to the four 15-day metabolic balance diet periods in each study. the last 10 da ...	1975	1168697
oestrogen and progesterone levels in the blood plasma of cows with normal parturition or with a retained placenta.		1975	1168708
incorporation of n-acetylglucosamine into the slime sheath of the cellular slime mould dictyostelium discoideum.		1975	1169163
the effects of pent-4-enoate and methylenecyclopropylacetate on some enzymes of beta-oxidation in extracts of liver mitochondria.		1975	1169177
endogenous prostaglandin release contributes directly to coronary artery tone.	an in vitro coronary artery preparation of beef heart was found to synthesize and release continuously large amounts of a prostaglandin of the e type. inhibition of prostaglandin synthesis with aspirin, indomethacin, or eicosa-5,8,11,14-tetraynoic acid induced a sustained contraction of the coronary artery, and pretreatment with indomethacin diminished markedly the output of prostaglandin into the bathing medium. it appears that prostaglandin e1, generated from within the vessel wall itself, may ...	1975	1175084
blood rheology and the distribution of blood flow within the nutrient capillaries.		1975	1180823
magnetic circular dichroism studies of hepatic microsomal cytochrome p-450.	magnetic circular dichroism (mcd) spectra have been measured for cytochrome p-450 (p-450) purified from phenobarbital-induced rabbit liver microsomes. the temperature dependence of some of the mcd spectra has also been determined. the mcd spectrum of oxidized p-450 seems to suggest that it is in a state intermediate between the ferric low-spin states. model experiments suggest that this anomaly arises from the coordination of a thiolate anion to the heme. reduced p-450 shows a very peculiar mcd ...	1975	1182096
metabolic actions of vasopressin, glucagon and adrenalin in the intact rat.	metabolic effects of vasopressin, glucagan and adrenalin were compared, in intact rats, especially in regard to time courses of effects. hyperglycaemia was transient in response to vasopressin, prolonged following adrenalin, and, suprisingly, was not discernible after glucagon, except in response to a very large dose. vasopressin decreased and adrenalin increased, the plasma free fatty acid concentration; both hormones decreased the triacylglycerol level. muscle glycogen concentrations, measured ...	1975	1182200
[characterization and physico-chemical properties of human transcortin].	the molecular weight of human transcortin, calculated from the sedimentation coefficient, was found to be 49,500, thus slightly lower than previously reported values. after purification, human transcortin trended to polymerize rapidly, with participation of both non covalent bonds and one disulfide bridge per dimer. the physicochemical parameters, the amino-acid and carbohydrate composition were determined; its stability was studied under different conditions. preliminary structural studies show ...	1975	1182213
[periodicity of changes in halobacterium cultures].		1975	1183309
plasma protein binding of drugs as a function of age in adult human subjects.	the intent of this study was to determine what influence, if any, increasing age has on the binding of drugs by plasma proteins. plasma from healthy subjects ranging in age from 21 to 94 years was used. the binding of phenytoin (diphenylhydantoin) (acid), penicillin g potassium (benzylpenicillin potassium), and phenobarbituric acid was determined by equilibrium dialysis of 14c-labeled compounds. no differences were found in total protein concentration; however, albumin was reduced in subjects ov ...	1975	1185544
preliminary report on the transmission of parafilaria bovicola in south africa.		1975	1187095
new drug evaluation using exercise-induced bronchospasm.	exercise-induced asthma was used to demonstrate that a xanthone, a new orally active cromolyn-like drug, has significant activity in man. the effect of a single oral dose of 8 mg/kg was studied in a double-blind corss-over fashion at two and five hours after administration, with significant inhibition of post-exercise bronchospasm being seen at five hours. further study seems indicated to determine optimal dosage and clinical effectiveness.	1975	1187285
osteomyelitis in infants and children. a review of 163 cases.	one hundred sixty-three cases of osteomyelitis in infants and children were seen at our hospital during the past 15 years. there were twice as many boys as girls. staphylococcus aureus was the major etiologic agent, being identified in 61% of the cases. gram-negative bacteria were responsible for only 14 cases (9%). the femur, the tibia, or the humerus were affected in 103 of the 152 patients with single bone involvement. ostoemyelitis of more than one bone was seen in 11 cases (7%). associated ...	1975	1190158
microcirculation of traumatized spinal cord. a correlation of microangiography and blood flow patterns in transitory and permanent paraplegia.	a relationship of microangiography and blood flow patterns in the contused feline spinal cord is reported. in transitory traumatic paraplegia, an injury from which there is a return of function in several weeks, impaired vascular perfusion occurs in the white matter through 1 hour after contusion, then stabilizes and returns to normal by 24 hours. in permanent traumatic paraplegia, an injury from which no sensory or motor function returns, the vascular perfusion of the white matter continues to ...	1975	1195437
synchronization of the fission yeast schizosaccharomyces pombe using heat shocks.		1975	1196141
pharmacological investigations on elaeocarpus ganitrus.		1975	1197422
[non-propagated potentials in the electromyogram of mammalian ocular muscles].	electromyograms of mammalian extraocular muscles were recorded by means of a coaxial electrode. besides normal extracellular spike potentials (1-2 msec duration), monophasic waves (with a decline lasting up to 7 msec) were recorded. as to the interpretation of these potential changes in terms of a potential drop that is produced by local currents flowing from the resting region of a fibre towards the active region consideration is given to two cases. first, a propagated active region (spike pote ...	1975	1199599
an improved method of assessing topical corticosteroid activity.	topical application of ointment bases causes varying degrees of epidermal thickening in guinea-pigs. this is reproducible and can be accurately measured. suppression of these changes was produced by addition of beta-methasone 17-valerate, fluocinolone acetonide, fluocinonide and hydrocortisone acetate. the inhibitory effect of these steroids was related to the type of corticosteriod, its concentration and the ointment base. the effect was still evident at extremely high dilutions of the steroids ...	1975	1201192
abnormal membrane surface properties during maturation of rat reticulocytes elicited by bleeding as measured by partition in two-polymer aqueous phases.	partition of cells in two-polymer aqueous phases is an extremely sensitive method for the separation of cells and for tracing subtle changes in the cells' membrane surface properties (primarily surface charge) as a function of in vivo processes (e.g. differentiation, maturation, ageing). combining isotope labelling and cell countercurrent distribution techniques we have examined the membrane surface properties of rat reticulocytes produced in response to erythroid stress by bleeding. it was foun ...	1975	1201234
[electron microscopic study of double infection induced by potato virus x and potato virus y in nicotiana glutinosa].		1975	1214639
[salmonellosis carrier state].		1975	1214656
[remarks on the ecological adaptation of the snail aquatic fauna in saline medium of the dallol ponds. (republique du niger) (author's transl)].	human vesical and intestinal bilharziasis, bovine fasciolosis and paramphistomosis, equine gastrodiscosis and ovine carmyeriosis, are frequent in the dallols'region, (12 degrees - 13 degrees 30 n. lat. ; 3 degrees e. long.), republique du niger, africa. dallols are fossil valleys pouring water from late saharian lakes. they are also tributaries of the niger river. during the dry season, they become dry and many residual ponds of varied dimensions; from tens feet to one or two miles long, are lyi ...	1975	1221913
[the barrier function of supportive cells of the receptor division of the olfactory analyzer].		1975	1231083
[role of tissue blood-coagulating compounds in the pathogenesis of posttraumatic acute renal insufficiency].		1975	1231108
[effect of x-rays on human adult skin explants].		1975	1233920
[influence of endogenous factors on the ash, calcium, magnesium, potassium, sodium, phosphorus, zinc, iron, copper and manganese contents in the bristles of pigs. 3. influence of time of cutting on the mineral composition of the hair (boar bristles)].	the ash content and the content of ca, mg, k, and na in the bristles of pigs is influenced by the age of the animal and by the season of the year. the peak concentrations of ash, ca and mg in the bristles of eight boars (cut every month) were found in june, shortly before the change in hair coat. (p less than 0.05-0.001). the concentrations of k and na in the bristles deviated functionally from the change in the hair coat. in the first half of the year the bristles of the boars contained signifi ...	1975	1233935
[studies on the 14c-15n-acetamide turnover in sheep. 1. studies on the 14c turnover].	4 male sheep (average weight: 53.5 kgs) were fed a semisynthetic diet containing acetamide as sole source of nitrogen. at the beginning of the trial twin-labelled 15n-14c-acetamide was administered by way of a ruminal fistula. the curve pattern of 14c activity in the tce-soluble fraction of the ruminal fluid showed a synchronous behaviour in all animals beginning at 3 hours after the beginning of the trial. a half-life of 2 1/2 hours for the rate of absorption of 14c acetamide and deaminated 14c ...	1975	1233939
[studies on the protein and amino acid metabolism of laying hens using 15n labeled casein. 15n concentration in the intestinal content and intestinal tissue in relation to the time of the last 15n administration].	four laying hens with anus praeternaturalis were fed 15n casein for a period of 6 experimental days. each experimental bird thus received a 15n excess (15n') of 154.44 mg. 11.54 mg of 15n' were found in lysine 3.99 mg in histidine and 9.58 mg in arginine. 2 hens were slaughtered 48 hours after the last 15n dose; another 2 were sacrificed after 144 hrs. in this investigation the n content of the intestinal contents and in the proteins of the small and large intestine were determined. the average ...	1975	1233975
measurement of plasma prednisolone in man.	1. a modification of the competitive protein binding assay for prednisolone described by english, chakraborty & marks (1974) is presented. 2. addition of pg quantities of [3h]-prednisolone following oral dosage with prednisone or prednisolone. 3. mean plasma half-life and peak plasma concentrations in patients with respiratory disease seen following prednisolone administration agree well with previous studies in healthy volunteers performed by other workers using competitive protein binding and ...	1975	1233991
hbs-ag, hbc-ag and virus-like particles in liver tissue.	hepatitis b surface antigen (hbs-ag) and hepatitis b core antigen (hbc-ag) in hepatic tissue of 3 cases with various liver diseases were investigated by immunofluorescent method. virus-like particles were demonstrated by electron microscopy in the nuclei of these 3 cases. the localization of hbs-ag was restricted in cytoplasma or on the surface of hepatocyte, while hbc-ag was almost in the hepatocytic nuclei. however, there was unexplainable discrepancy between the distribution of hbs-ag and tha ...	1975	1234098
[action of clostridial spores on transplantation tumors in alloxan-diabetic rats (author's transl)].	with the intention to improve the up to now unsatisfying effectiveness of tumour treatment by clostridial spores, the influence of alloxan-induced hyperlglycemia on clostridial therapy in two transplantable tumours of the rat are examined. contrary to the isolated clostridial application the combined treatment causes a significant improvement of therapeutic effects (tumour-necrosis and -liquefaction, decreased growth-rate-quotient). the examination of antibody titers against clostridial rods sho ...	1975	1235792
[influence of "clumping factor" from staphylococcus aureus on phagocytosis (author's transl)].	in phagocytosis experiments the pathogenic significance of the "clumping factor" (cf) of staphylococcus aureus was studied. cf-positive staphylococci were engulfed considerably less by leukocytes from rabbits and cattle than cf-negative staphylococci. equally, the engulfment of staphylococcal skeletons (ssk) coupled with partially purified cf was significantly less than that of the ssk. the ssk had been prepared by extraction of staphylocci with formic acid. by this method the ssk were freed of ...	1975	1239146
stochastic model of contractions at a point in the duodenum.	contractions at one point in the human duodenum were studied as a time series. manometric records were made over long time periods from the duodenum in fed human subjects. a 5-s grid was superimposed on the time axis of the records. each 5-s interval was treated as a slow-wave cycle within which either a contraction or a no-contraction could occur. the resulting series of alternating runs of contractions and no-contractions was tested for the existence of trends. trends were found indicating pos ...	1975	1243240
[simultaneous vaccination with bcg and measles vaccine: results of a controlled trial].	the main purpose of the controled assay on a combination of b.c.g. and measles vaccine was to ascertain whether these two vaccines could be administered on young children in simultaneous injections, in two different parts of the body and on the same day, and whether in that case they led to rates of haemagglutination inhibitory antibodies against measles on the one hand, and induration diameters of mantoux's intradermoreactions against b.c.g. on the other, not inferior to rates and diameters obt ...	1975	1084093
cefamandole: antimicrobial activity in vitro of a new cephalosporin.	cefamandole, a new cephalosporin derivative, was found to have a broad spectrum of activity against a cross-section of both gram-positive and gram-negative bacteria isolated from clinical material. gram-positive cocci, except for streptococcus faecalis, were very susceptible. penicillin g-resistant staphylococcus aureus also was susceptible to cefamandole. minimal bactericidal concentrations for gram-positive cocci approximated the minimal inhibitory concentrations. strains of haemophilus influe ...	1975	1044248
haemophilus influenzae as a cause of salpingitis.	a case is reported of acute unilateral salpingitis, the cause of which was haemophilus influenzae cultured from a pus sample taken from the infected fallopian tube during laparotomy. the significance of the findings is discussed with reference to the literature.	1975	1082288
microdilution technique for antimicrobial susceptibility testing of haemophilus influenzae.	a microdilution method incorporating the use of color-defined growth end points was compared with a conventional broth tube dilution procedure for susceptibility testing of haemophilus influenzae with ampicillin and chloramphenicol. the microdilution method allowed rapid performance of dilution susceptibility tests with easily defined end points.	1975	1082292
influences of media and inocula on the in vitro susceptibility of haemophilus influenzae to co-trimoxazole, ampicillin, penicillin, and chloramphenicol.	the effects of inocula and media on the activities of ampicillin, penicillin, chloramphenicol and co-trimoxazole against haemophilus influenzae were examined in vitro. two inocula and four media were tested by the disk diffusion, broth dilution, and agar dilution methods. chloramphenicol activity versus h. influenzae was least affected by changes in inocula and media, whereas co-trimoxazole was most susceptible to these effects. filde's and levinthal's agar dilution tests were most satisfactory ...	1975	1082293
[anti-inflammatory, analgesic and antipyretic actions of 1-(m-chlorophenyl)-3-n, n-dimethylcarbamoyl-5-methoxypyrazole (pz-177)].	we have reported that pz-177 was found to have potent inhibitory activity on acute inflammatory edema. in this paper, the anti-inflammatory, analgesic and antipyretic properties of pz-177 were assessed by a battery of standard tests. pz-177 inhibited the increased vascular permeability induced by histamine, xylene and acetic acid. the activity was the same as the anti-edematous one and was more potent than that of mepirizole. pz-177 did not inhibit ultraviolet erythema in guinea pigs, proliferat ...	1975	1082832
growth and death of diploid and transformed human fibroblasts.	three possible explanations are presented for the differences in growth potential between human diploid fibroblasts of finite life-span and permanent transformed lines: 1) only diploid cells have a molecular clock mechanism which counts cell divisions prior to senescence. two hypothetical examples of such mechanisms are described; however, the available evidence argues against a clock mechanism for aging in fibroblasts. 2) cells become committed with a given probability to a slow buildup in prot ...	1975	1088944
identification and characterization of the in vitro synthesized gene products of bacteriophage m13.	bacteriophage m13 replicative form (rf) dna was used to direct coupled transcription and translation in cell-free extracts prepared from escherichia coli. by using rf dna, isolated from cells infected with appropriate amber mutants of this phage, it has been possible to identify the products of genes i through iv. by using the same methods no gene-product relationship could be demonstrated for genes vi and vii. coupled in vitro protein synthesis studies on rf-iii dna, a linear double-stranded dn ...	1975	1089807
energy efficiency of intraperiplasmic growth of bdellovibrio bacteriovorus.	the y-atp (energy efficiency) of intraperiplasmic growth of bdellovibrio bacteriovorus was determined from the distribution of radioactivity of the substrate organism ([u-14c]escherichia coli) btween co2 and bdellovibrio cells at the end of growth. a "best" y-atp value of 18.5 was obtained from single growth cycle experiments and an average value of 25.9 from multicycle experiments. both values are much higher than the usual value of 10.5 for bacteria growing in rich media. the bases for the unu ...	1975	1090596
purification of an inhibitor of dna photolyase with fluorescent spectra similar to those of the enzyme.	1. the binding of dna photolyase, the enzyme which uncouples cyclobutadipyrimidines in dna upon illumination, to its substrate was enhanced by a substance isolated from acidified autolysates of baker's yeast. 2. this substance, referred to as activator, was partially purified by chloroform extraction, ion-exchange chromatography on dowex 50 and deae-cellulose, and gel filtration on sephadex g-10. upon lyophilization and storage at -20 degrees c, it was converted to a potent inhibitor of enzyme b ...	1975	1091298
heteroimmunization to the capsular polysaccharide of haemophilus influenzae type b induced by enteric cross-reacting bacteria.	cross-reacting escherichia coli strains easter and 89 and bacillus pumilis fed to newborn rabbits and e. coli fed to adult rhesus monkeys did not exert untoward reactions. the e. coli regularly colonized the newborns' intestinal tract from 1 to 7 weeks. high doses of e. coli were necessary to colonize adult primates. colonization occurred in fewer newborn rabbits and lasted only 1 to 3 weeks with b. pumilis. colonized newborn rabbits and adult rhesus had an active haemophilus influenzae type b ( ...	1975	1091559
meningitis caused by streptococcus in adults.	meningitis caused by streptococcus is uncommon in adults. otitis media, mastoiditis, sinusitis, or trauma has antedated most cases reported in the past. data on 10 recent cases suggest changes in the current pathogenesis of streptococcal meningitis in adults and emphasize the importance of accurate streptococcal speciation. endocarditis was present in five cases; trauma played a role in two others. brain abscess, corticosteroids, alcoholic cirrhosis, and peritonitis secondary to chronic peritone ...	1975	1092775
editorial: fecal flora and resistance to invasive bacteria.		1975	1093021
diseases of the tonsils and adenoids in adults.		1975	1093477
natural history of otitis media.		1975	1093478
in vitro sensitivity of hemophilus influenzae and streptococcus pyogenes to co-trimoxazole.	the invitro testing of hemophilus influenzae and streptococcus pyogenes for co-trimoxazole sensitivity requires certain "defined" media that have to be free of inhibitory substances. the use of columbia agar base with fildes extract for h. influenzae or of blood agar for s. pyogenes may produce "false-resistant" strains. the addition of thymidine phosphorylases in the form of gentlylysed horse blood (2 to 10%) does not remove all inhibitors in those tests, especially where "undefined" agar bases ...	1975	1093653