Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| current epidemiology of hepatitis e virus infection in the united states: low seroprevalence in the national health and nutrition evaluation survey. | analysis of the national health and nutrition evaluation survey (nhanes) 1988-1994 dataset found a relatively high seroprevalence (21%) of hepatitis e virus (hev) infection in the u.s. general population. using data obtained within the nhanes 2009-2010 survey, where a high performance assay for hev was used, we estimated the weighted seroprevalence of hev infection among u.s. individuals 6 years and older. we also evaluated factors associated with hev seropositivity. a total of 8,814 individuals ... | 2014 | 24824965 |
| bioaccumulation efficiency, tissue distribution, and environmental occurrence of hepatitis e virus in bivalve shellfish from france. | hepatitis e virus (hev), an enteric pathogen of both humans and animals, is excreted by infected individuals and is therefore present in wastewaters and coastal waters. as bivalve molluscan shellfish are known to concentrate viral particles during the process of filter feeding, they may accumulate this virus. the bioaccumulation efficiencies of oysters (crassostrea gigas), flat oysters (ostrea edulis), mussels (mytilus edulis), and clams (ruditapes philippinarum) were compared at different time ... | 2014 | 24795382 |
| hepatitis e-associated encephalopathy in a renal transplant recipient. | hepatitis e virus genotype 3 is not rare in developed countries, and may cause chronic hepatitis in immunocompromised patients. this may not only lead to abnormalities in liver test and malaise, but to severe neurological symptoms as well. in this case, chronic hepatitis e infection caused encephalopathy, an atactic gait, lhermitte's sign, incomplete bladder emptying and peripheral sensory neuropathy in a renal transplant recipient. the diagnosis was not performed until years after the onset of ... | 2014 | 24789162 |
| phylogeography and phylodynamics of european genotype 3 hepatitis e virus. | hepatitis e virus is classified into four genotypes that have different geographical and host distributions. the main cause of sporadic autochthonous type e acute hepatitis in developed countries is genotype 3, which has a worldwide distribution and widely infects pigs. the aim of this study was to make hypotheses concerning the origin and global dispersion routes of this genotype by reconstructing the spatial and temporal dynamics of 208 hev genotype 3 orf-2 sequences (retrieved from public dat ... | 2014 | 24787998 |
| an orf1-rearranged hepatitis e virus derived from a chronically infected patient efficiently replicates in cell culture. | hepatitis e is an increasingly reported disease in industrialized countries. studies on the replication cycle of hepatitis e virus (hev) are hampered due to the lack of efficient and robust cell culture systems for this virus. we describe the successful isolation of hev derived from a chronically infected kidney transplant patient held under immunosuppressive therapy. inoculation of serum sample 47832 onto the human lung carcinoma cell line a549 resulted in the replication of the virus as shown ... | 2014 | 24750215 |
| seroprevalence of hepatitis e virus (hev) in humans living in high pig density areas of germany. | an increase in acute autochthonous hepatitis e virus (hev) infections has been recorded in germany. these are suspected to be zoonotically transmitted from wild boar, deer and domestic pig. the latter may represent a major reservoir for hev. in this study, 537 sera from humans living in westphalia and lower saxony, representing areas of high pig density in germany, were tested for the presence of hev-specific antibodies. among them were 302 individuals with occupational, direct contact to pigs a ... | 2014 | 24744181 |
| comparison of real-time pcr and antigen assays for detection of hepatitis e virus in blood donors. | hepatitis e virus (hev) infection is recognized as an emerging and often undiagnosed disease in industrialized countries, with asymptomatic infections actually occurring in blood donors. sensitive detection of hev-rna is crucial for diagnosis and monitoring of disease progression. we evaluated the analytical sensitivity and performance of three hev rt-pcr assays (realstar hev reverse transcription-pcr [rt-pcr], hepatitis@ceeramtools, and amplicube hev rt-pcr) for screening of individuals for hev ... | 2014 | 24740079 |
| development of a blocking elisa for detection of antibodies against avian hepatitis e virus. | a blocking enzyme-linked immunosorbent assay (belisa) was developed for the detection of immunoglobulin g antibodies against avian hepatitis e virus (hev). in the belisa, the coating antigen was a truncated protein containing c-terminal 268-amino acid region of orf2 from an avian hev strain isolated in china (cahev) and blocking antibody was a monoclonal antibody (mab) 1h5 recognizing the epitope within amino acids 384-414 in the c-terminal 268-amino acid region. the concentration of blocking ma ... | 2014 | 24735599 |
| prospective study of hepatitis e virus infection among pregnant women in france. | hepatitis e virus (hev) infection has a poor prognosis among pregnant women from high endemic countries. hev-prevalence and incidence among pregnant women is unknown in high-income countries such as france. this prospective study was conducted to assess hev infection in this setting. | 2014 | 24716485 |
| induction of antibody and interferon-γ production in mice immunized with virus-like particles of swine hepatitis e virus. | virus-like particles (vlps) composed of the truncated capsid protein of swine hepatitis e virus (hev) were developed and immune responses of mice immunized with the vlps were evaluated. igg titers specific for the capsid protein of swine hev were significantly higher for all groups of mice immunized with the vlps than those of the negative control mice. splenocytes from mice immunized with the vlps also produced significantly greater quantities of interferon (ifn)-γ than interleukin (il)-4 and i ... | 2014 | 24690608 |
| seroprevalence of hepatitis e virus in pigs from different farming systems in the netherlands. | sporadic nontravel-related hepatitis e virus (hev) infections have been reported in industrialized countries. these infections are caused by zoonotic hev genotypes 3 and 4 that circulate in swine, wild boar, and deer. in the netherlands, hev rna has been detected in >50% of the pig farms, and hev-specific antibodies were detected in ∼70% of the slaughter pigs. in the current study, hev seroprevalences were investigated in pigs raised on conventional, free-range, and organic farms in the netherla ... | 2014 | 24680077 |
| hepatitis e seroprevalence among blood donors: a pilot study from western india. | hepatitis e virus (hev) is emerging as a potential threat to blood safety after several cases of transmission by transfusion or transplantation have been described. currently, blood donors in india are not screened for hev. the studies conducted on hev in recent times in india have focused on epidemiology and future perspectives, but there is no published study on blood donors. to address possible issues surrounding blood safety and risk of hev transmission within the indian blood supply, hev se ... | 2014 | 24678170 |
| development and validation of a genotype 3 recombinant protein-based immunoassay for hepatitis e virus serology in swine. | hepatitis e virus (hev) is classified within the family hepeviridae, genus hepevirus. hev genotype 3 (gt3) infections are endemic in pigs in western europe and in north and south america and cause zoonotic infections in humans. several serological assays to detect hev antibodies in pigs have been developed, at first mainly based on hev genotype 1 (gt1) antigens. to develop a sensitive hev gt3 elisa, a recombinant baculovirus expression product of hev gt3 open reading frame-2 was produced and coa ... | 2014 | 24676472 |
| light and darkness: prevalence of hepatitis e virus infection among the general population. | human hepatitis e virus (hhev) spreads early in life among the population in areas endemic for genotype 1 and infects mainly adults in areas endemic for genotype 3, where it would be responsible for about 10% of cases of suspected acute viral hepatitis of unknown etiology and for a number of subclinical, unrecognized infections. the overall prevalence of antibody to hhev is high in most of the former areas and low in most of the later ones, but wide regional differences have been recorded in bot ... | 2014 | 24672733 |
| genetic host specificity of hepatitis e virus. | hepatitis e virus (hev) causes epidemic and sporadic cases of hepatitis worldwide. hev genotypes 3 (hev3) and 4 (hev4) infect humans and animals, with swine being the primary reservoir. the relevance of hev genetic diversity to host adaptation is poorly understood. we employed a bayesian network (bn) analysis of hev3 and hev4 to detect epistatic connectivity among protein sites and its association with the host specificity in each genotype. the data imply coevolution among ∼70% of polymorphic si ... | 2014 | 24667049 |
| autochthonous hepatitis e virus infections: a new transfusion-associated risk? | hepatitis e virus (hev) has been recognized since 2004 as a transfusion-transmissible infectious agent, and recent epidemiological data suggest that it may pose a safety threat to the blood supply. it has recently become obvious that hepatitis e is endemic in industrialized countries, and that more infections are autochthonous than travel-associated. epidemiological and phylogenetic analysis suggests that hev infection has to be considered as a zoonosis and that viral transmission from animals ( ... | 2014 | 24659945 |
| complete genome of hepatitis e virus from laboratory ferrets. | the complete genome of hepatitis e virus (hev) from laboratory ferrets imported from the united states was identified. this virus shared only 82.4%-82.5% nt sequence identities with strains from the netherlands, which indicated that the ferret hev genome is genetically diverse. some laboratory ferrets were contaminated with hev. | 2014 | 24655541 |
| rat hepatitis e virus derived from wild rats (rattus rattus) propagates efficiently in human hepatoma cell lines. | although rat hepatitis e virus (hev) has been identified in wild rats, no cell culture systems for this virus have been established. a recent report suggesting the presence of antibodies against rat hev in human sera encouraged us to cultivate rat hev in human cells. when liver homogenates obtained from wild rats (rattus rattus) in indonesia were inoculated onto human hepatocarcinoma cells, the rat hev replicated efficiently in plc/prf/5, huh-7 and hepg2 cells, irrespective of its genetic group ... | 2014 | 24631787 |
| complete genome sequence of swine hepatitis e virus prevalent in southwest china. | hepatitis e virus (hev) is an important public health concern in the world, especially in developing countries of africa and asia, including china. hepatitis e is recognized as a zoonotic disease, which is transmitted across species, including between humans and swine. hev is highly endemic in china, but the complete sequence of hev in southwestern china is lacking. swine hev strain km01 was isolated from a village in rural kunming, yunnan province, china, where swine are housed with humans. her ... | 2014 | 24625866 |
| evidence of extrahepatic replication of hepatitis e virus in human placenta. | the incidence and severity of hepatitis e virus (hev) infection in pregnant women is high in developing countries. transplacental transmission of hev in the third trimester of pregnancy has been found to be associated with high fetal mortality. based on this evidence and in the absence of reports on hev replication in extrahepatic sites, this study was carried out to investigate if hev replication occurs in the placenta of infected mothers. the study included 68 acute viral hepatitis (avh) and 2 ... | 2014 | 24622580 |
| withdrawn: seroepidemiology of hepatitis e virus in western iran. | the publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.bbr.2011.03.031. the duplicate article has therefore been withdrawn. | 2014 | 24613783 |
| pet veterinarians have no increased risk of hepatitis e compared to the general population. | the discovery of autochthonous hepatitis e in industrialized countries associated to genotype 3 has changed substantially the understanding about hepatitis e virus (hev) circulation. in these countries transmission has been associated to the consumption and direct contact to swine, a well-known reservoir for hev. more animal reservoirs for hev might exist since antibodies to hev have been detected in other animal species, such as dogs and cats. given the intimate contact between these pets and h ... | 2014 | 24610550 |
| association of pregnancy outcome with cytokine gene polymorphisms in hev infection during pregnancy. | hepatitis e virus (hev) infection is associated with high maternal and fetal mortalities. the aim of the study was to find cytokine gene polymorphisms in relation to hev infection during pregnancy. a total of 262 pregnant and 208 non-pregnant women with hepatitis, 262 healthy pregnant and 208 non-pregnant women as controls. the study group were pregnant and non-pregnant women with hev infection, not infected with hev and controls. genotyping was carried out by pcr-rflp and arms-pcr methods. the ... | 2014 | 24610501 |
| pregnant woman saved with liver transplantation from acute liver failure due to hepatitis e virus. | 2014 | 24606386 | |
| persistent hepatitis e virus genotype 4 infection in a child with acute lymphoblastic leukemia. | in general, the hepatitis e virus (hev) causes acute, self-limiting hepatitis. prolonged and chronic infections caused by hev genotype 3 have been found in some immunosuppressed patients in developed countries. | 2014 | 24596581 |
| hev-orf3 encoding phosphoprotein interacts with hepsin. | hepatitis e virus (hev) is a major causative agent of acute clinical hepatitis in adults through much of asia, the middle east and africa. open reading frame 3 (orf3) encodes around 120 amino acids of phosphorylation protein that associates with the cytoskeleton, while its precise biological function is still unknown. | 2014 | 24596579 |
| detection and localization of rabbit hepatitis e virus and antigen in systemic tissues from experimentally intraperitoneally infected rabbits. | rabbit hepatitis e virus (hev) is a novel genotype of hev, and is considered to pose a risk of zoonotic transmission. research into the systemic distribution of rabbit hev in rabbits during different periods of infection has rarely been reported. to better understand this virus, we infected rabbits with second-passage rabbit hev via an intraperitoneal route. after inoculation, the infection showed two types, temporary and constant infection. the detection of hev rna in the feces varied with time ... | 2014 | 24594631 |
| molecular detection of hepatitis e virus in rivers in the philippines. | to understand the hepatitis e virus (hev)-pollution status in the environment in the philippines, a total of 12 water samples were collected from rivers in manila city for detection of hev rna. three of 12 samples were positive for hev rna indicating that hev is circulating in the philippines. phylogenetic analysis classified all of the hev sequences into genotype 3. | 2014 | 24591433 |
| hepatitis e virus: current concepts and future perspectives. | for many years, hepatitis e was considered a disease found only in certain developing countries. in these geographical settings, hepatitis e virus (hev) causes a self-limiting hepatitis in young adults, except in pregnant females, in whom the mortality is 25 %. our understanding of hev has changed radically in the past decade. it is now evident that hev is a threat to global health. this review article considers the current concepts and future perspectives of hev and its effects on human health, ... | 2014 | 24585215 |
| calcineurin inhibitors stimulate and mycophenolic acid inhibits replication of hepatitis e virus. | many recipients of organ transplants develop chronic hepatitis, due to infection with the hepatitis e virus (hev). although chronic hev infection is generally associated with immunosuppressive therapies, little is known about how different immunosuppressants affect hev infection. | 2014 | 24582714 |
| autochthonous hepatitis e virus infection in europe: a matter of concern for public health? | human hepatitis e virus (hhev) is the proposed name for a diverse group of rna viruses from the family hepeviridae that cause acute hepatitis among humans. waterborne strains are regularly imported into europe by international travelers, and virus transmission of zoonotic strains via contaminated aliments is involved in autochthonous cases. therefore, in europe, hepatitis e displays a unique dual character, having features of both imported and autochthonous infections. environmental involvement ... | 2014 | 26357613 |
| genome-wide comparisons of phylogenetic similarities between partial genomic regions and the full-length genome in hepatitis e virus genotyping. | besides the complete genome, different partial genomic sequences of hepatitis e virus (hev) have been used in genotyping studies, making it difficult to compare the results based on them. no commonly agreed partial region for hev genotyping has been determined. in this study, we used a statistical method to evaluate the phylogenetic performance of each partial genomic sequence from a genome wide, by comparisons of evolutionary distances between genomic regions and the full-length genomes of 101 ... | 2014 | 25542033 |
| no transmission of hepatitis e virus in pigs fed diets containing commercial spray-dried porcine plasma: a retrospective study of samples from several swine trials. | hepatitis e virus (hev) has been reported in the human population and pigs are a recognized reservoir for hev and a possible source of hev transmission to humans. spray-dried porcine plasma (sdpp) is an ingredient commonly used in feed for pigs around the world. even though processing conditions used to produce sdpp should be adequate to inactivate hev, it was of interest to analyze commercial sdpp samples for presence of genome and antibodies (ab) against hev and to retrospectively analyze seru ... | 2014 | 25539662 |
| acute hepatitis e virus infection and association with a subacute thyroiditis. | 2014 | 25536654 | |
| gb virus c viremia and anti-e2 antibody response among hemodialysis patients in gorgan, iran. | gb virus c is a blood-borne virus and a member of flaviviridae, like hepatitis c that is distributed globally and puts hemodialysis patients at high risk of developing liver disease. the clinical significance of gbv-c in this population remains unclear. | 2014 | 25774276 |
| seroprevalence and risk factors associated with hepatitis e virus infection in three species of pet birds in northwest china. | hepatitis e virus (hev), the causative agent of hepatitis e, has been reported in a wide variety of animals, including birds, but little is known of hev infection in pet birds in northwest china. the objective of the present investigation was to examine hev seroprevalence in three species of pet birds, namely, eurasian siskin, oriental skylark, and black-tailed grosbeak from gansu. serum samples collected from 685 pet birds from august 2011 to september 2012 were examined independently for the p ... | 2014 | 25530995 |
| hepatitis e in developed countries: current status and future perspectives. | hepatitis e virus (hev) was for many years thought to be found almost exclusively in developing countries, where it is a major health issue. recent studies have shown that hev causes acute and chronic infection in developed countries. in these geographical settings, hev is primarily a porcine zoonosis caused by genotypes 3 (hev3) and 4 (hev4). the clinical phenotype of hepatitis e continues to emerge, and recent data show that hev is associated with a range of neurological syndromes including gu ... | 2014 | 25517900 |
| epidemiology and associated risk factors of hepatitis e virus infection in plateau state, nigeria. | a cross-sectional study in nigeria was undertaken to determine the epidemiology, seroprevalence, and associated risk factors, of hepatitis e virus (hev). a total of 462 subjects were used for the study, categorized into four groups: apparently healthy persons, pregnant women, hiv positive subjects, and animal handlers. information was obtained from subjects using interviewer-administered questionnaire. blood samples were collected and analyzed for hev antibodies (igg and igm) using enzyme-linked ... | 2014 | 25512696 |
| [analysis of epidemiologic and etiology of hepatitis e in hangzhou, 2004-2011]. | to comprehend the epidemiologic of hepatitis e and genetic characteristics of hepatitis e virus (hev) in hangzhou from 2004 to 2011. | 2014 | 25492286 |
| [hepatitis e virus infection in patients with clinical diagnosis of viral hepatitis in colombia]. | hepatitis e virus (hev) is an emergent virus of global importance; it is the etiological agent of sporadic cases and outbreaks of hepatitis. the epidemiology of this infection in colombia is unknown. | 2014 | 25504123 |
| first report of chronic hepatitis e in renal transplant recipients in portugal. | hepatitis e virus (hev) infection can be responsible for chronic hepatitis in immunocompromised patients, and can rapidly evolve into fibrosis and/or hepatic cirrhosis. we present two cases of chronic hepatitis e, emphasizing the need to be aware of this entity as a growing etiology of hepatitis in transplant and immunocompromised patients. | 2014 | 25500665 |
| toll like receptors in self-recovering hepatitis e patients with or without pregnancy. | hepatitis e virus (hev) causes high mortality among pregnant women. pathogenesis of hev, especially during pregnancy, is poorly understood. our aim was to assess the role of toll-like-receptors (tlrs) in hepatitis e patients with pregnancy (antenatal care, anc) or without pregnancy (non-anc). the patient categories included acute-phase, non-anc (n=46) and anc patients (2nd/3rd trimesters, n=13) and non-anc patients (n=31) during convalescence. controls included apparently healthy non-anc (n=30) ... | 2014 | 25454620 |
| evidence of hepatitis e infection in swine and humans in the east region of romania. | swine hepatitis e virus (hev) is considered to be a new zoonotic agent due to its close genomic resemblance to the human hev. the aim of this study was to determine human hev seroprevalence in eastern romania and to characterize circulating swine hev sequences. | 2014 | 25447729 |
| seroepidemiology and genetic characterization of hepatitis e virus in western yunnan province. | to investigate the seroepidemiology and genetic characterization of hepatitis e virus (hev) in western yunnan province. | 2014 | 25441993 |
| hepatitis e virus genotype 4 in yak, northwestern china. | 2014 | 25419958 | |
| natural and experimental hepatitis e virus genotype 3-infection in european wild boar is transmissible to domestic pigs. | hepatitis e virus (hev) is the causative agent of acute hepatitis e in humans in developing countries, but sporadic and autochthonous cases do also occur in industrialised countries. in europe, food-borne zoonotic transmission of genotype 3 (gt3) has been associated with domestic pig and wild boar. however, little is known about the course of hev infection in european wild boar and their role in hev transmission to domestic pigs. to investigate the transmissibility and pathogenesis of wild boar- ... | 2014 | 25421429 |
| rna transcripts of full-length cdna clones of rabbit hepatitis e virus are infectious in rabbits. | hepatitis e virus (hev), the causative agent of hepatitis e, is a single-stranded positive-sense rna virus belonging to the family hepeviridae. at least four genotypes of the family infect humans: genotypes 1 and 2 are transmitted to humans through contaminated water, while genotypes 3 and 4 are zoonotic and have animal reservoirs. a novel strain of hev recently identified in rabbits is a distant member of genotype 3, and thus poses a potential risk of zoonotic transmission to humans. the object ... | 2014 | 25381057 |
| complete genome sequence of a rat hepatitis e virus strain isolated in the united states. | hepatitis e virus is a common cause of acute hepatitis in humans. related viruses have been isolated from multiple animal species, including rats, but their impact on human health is unclear. we present the first full-length genome sequence of a rat hepatitis e virus strain isolated in the united states (la-b350). | 2014 | 25377700 |
| analysis of hepatitis e virus-like sequence in chimpanzee. | 2014 | 25368657 | |
| naked viruses that aren't always naked: quasi-enveloped agents of acute hepatitis. | historically, viruses were considered to be either enveloped or nonenveloped. however, recent work on hepatitis a virus and hepatitis e virus challenges this long-held tenet. whereas these human pathogens are shed in feces as naked nonenveloped virions, recent studies indicate that both circulate in the blood completely masked in membranes during acute infection. these membrane-wrapped virions are as infectious as their naked counterparts, although they do not express a virally encoded protein o ... | 2014 | 26958733 |
| epidemiology of hepatitis e virus in china: results from the third national viral hepatitis prevalence survey, 2005-2006. | in china, hepatitis e virus (hev) is prevalent and causes disease, but its epidemiological profile is not well understood. we used a commercial enzyme-linked immunosorbent assay to detect total antibodies to hepatitis e virus in 15,862 serum samples collected during the third national viral hepatitis prevalence survey. the results were analyzed to calculate estimates of hev seroprevalence and to examine the effects of some putative risk factors. the seroprevalence of hev in the general chinese p ... | 2014 | 25360522 |
| hepatitis e virus and implications for blood supply safety, australia. | 2014 | 25341023 | |
| hepatitis e virus infections in blood donors, france. | we screened plasma samples (minipools of 96 samples, corresponding to 53,234 blood donations) from france that had been processed with solvent-detergent for hepatitis e virus rna. the detection rate was 1 hev-positive sample/2,218 blood donations. most samples (22/24) from viremic donors were negative for igg and igm against hev. | 2014 | 25340881 |
| frequent hepatitis e virus contamination in food containing raw pork liver, france. | food products containing raw pork liver are suspected to be vehicles for transmission of hepatitis e virus. four categories of food products, comprising 394 samples, were analyzed to determine hepatitis e virus prevalence. virus was detected in 3%-30% of the different categories. phylogenetic analysis showed high identity with human and swine sequences. | 2014 | 25340373 |
| foodborne transmission of hepatitis e virus from raw pork liver sausage, france. | 2014 | 25340356 | |
| new foe treated with old guns - supportive role of steroids in the treatment of acute severe hepatitis e. | autochthonous hepatitis e has been observed with growing incidence in industrialized countries. hepatitis e virus infection causes an acute hepatitis with spontaneous resolution in the majority of cases. however, in individual cases, hepatitis e may lead to life-threatening acute liver failure. in this report, we describe a case of acute liver injury caused by an autochthonous hepatitis e that resolved under steroid treatment. to our knowledge, this is the first case report describing supportive ... | 2014 | 25398314 |
| [search for rna of the hepatitis e virus autochthonous for russia in the most likely infection sources]. | the research carried out for 30 years from the moment of hepatitis e virus (hev) discovery has proved the presence of the autochthonous hev in non-endemic areas: europe and russia. monitoring of the hev antibodies (anti-hev) among the russian population has revealed regions with increased seroprevalence that testifies to high probability of local hev infection in these areas. contact with hev can represent special danger for patients of the risk groups. in this work, the blood sera testing was c ... | 2014 | 25335410 |
| extra-hepatic manifestations of autochthonous hepatitis e infection. | autochthonous (locally acquired) hepatitis e is increasingly recognised in developed countries, and is thought to be a porcine zoonosis. a range of extra-hepatic manifestations of hepatitis e infection have been described, but have never been systematically studied. | 2014 | 25303615 |
| hepatitis e infection in a renal transplant recipient. | an asymptomatic 35-year-old renal transplant recipient was noted to have deranged liver function tests. liver biopsy revealed a portal inflammatory process with mild lobular activity and portal fibrous expansion, consistent with a virally mediated process. an extensive viral screen confirmed infection with hepatitis e virus genotype 3 (hev-3). there is increased awareness about locally acquired hepatitis e virus (hev) infection in the transplant population in the uk. the important implications o ... | 2014 | 25295201 |
| phylogenetic analysis of hepatitis e virus in domestic swine and wild boar in germany. | hepatitis e virus (hev) is an emerging non-enveloped positive strand rna virus with worldwide distribution that can cause acute liver disease in humans. the virus has also been detected in both domestic and wild animals. in this study we investigated the presence of hev in free-living wild boar as well as in domestic swine. a total of 105 domestic swine fecal samples and 124 wild boar sera were tested for the presence of hev rna by rt-pcr. a 241 nucleotide (nt) fragment from the capsid gene of h ... | 2014 | 25287630 |
| hepatitis e in germany--an under-reported infectious disease. | at least 17% of the population in germany has been infected with the hepatitis e virus (hev); thus, hev infections are more frequent than was previously assumed. however, fewer than 500 hev infections were reported to the robert koch institute in 2013. | 2014 | 25249359 |
| hepatitis e virus (hev) seroprevalence in the general population of the republic of korea in 2007-2009: a nationwide cross-sectional study. | hepatitis e virus (hev) is an emerging pathogen associated with endemic and acute viral hepatitis. in this study, we investigate the hev seroprevalence and putative risk factors by a nationwide cross-sectional study in the republic of korea. | 2014 | 25248488 |
| [feasibility of hev vaccine as control in hpv vaccine study and comparison of serological and risk factors between hev and hpv infection among females]. | investigating the distribution of anti-hepatitis e virus (hev-igg), anti-human papillomavirus (hpv l1-igg) and risk factors among female residents in xinmi county, to explore the influencing factors of hpv vaccine study using hev vaccinated population as a control. | 2014 | 25241795 |
| seroprevalence of hepatitis e virus infection in psychiatric patients and control subjects in shandong province, eastern china. | hepatitis e, caused by the hepatitis e virus (hev), is an important global public health concern. there are conflicting reports in regard to the association of hev infection and psychiatric disorders. therefore, we investigated this association in a chinese population through a case-control seroprevalence study. | 2014 | 25220239 |
| first detection of hepatitis e virus in central argentina: environmental and serological survey. | the hepatitis e virus (hev) is an emergent causative agent of acute hepatitis worldwide, transmitted by fecal-oral route. in argentina it is considered rare, so differential laboratory testing is not routinely performed. besides, in argentina's central area epidemiological and molecular characteristics of hev are still unknown. | 2014 | 25213209 |
| identification of an antigenic domain in the n-terminal region of avian hepatitis e virus (hev) capsid protein that is not common to swine and human hevs. | the antigenic domains located in the c-terminal 268 amino acid residues of avian hepatitis e virus (hev) capsid protein have been characterized. this region shares common epitopes with swine and human hevs. however, epitopes in the n-terminal 338 amino acid residues have never been reported. in this study, an antigenic domain located between amino acids 23 and 85 was identified by indirect elisa using the truncated recombinant capsid proteins as coating antigens and anti-avian hev chicken sera a ... | 2014 | 25209807 |
| [construction and investigation of a recombinant eukaryotic expression vector for expressing the orf3 protein of hepatitis e virus in bhk-21 fibroblasts]. | to construct a eukaryotic expression vector to express the hepatitis e virus protein open reading frame 3 (orf3) and investigate the intracellular location of the expressed protein using the baby hamster kidney (bhk-21) fibroblast cell line. | 2014 | 25203800 |
| [serum anti-hepatitis e virus igg antibody and risk factors among female residents of xinmi in henan province]. | to determine the distribution of anti-hepatitis e virus (hev) igg antibody and anti-human papilloma virus (hpv) igg antibody among female residents of xinmi and investigate the risk factors of hev infection. | 2014 | 25203701 |
| chronic hepatitis e virus infection in a pediatric female liver transplant recipient. | we describe a case of chronic hepatitis e virus (hev) infection in a 13-year-old female liver transplant recipient with recurrent increased aminotransferase levels and acute cellular rejection. this finding demonstrates that chronic hev infection can occur and should be further investigated in immunocompromised patients in latin america. | 2014 | 25275004 |
| [hepatitis e virus: blood transfusion implications]. | hepatitis e virus (hev) is a non-enveloped rna virus transmitted by the fecal-oral route. autochthonous hepatitis e occurring in developed countries is caused by genotypes 3 and 4 and is a zoonotic infection. humans are infected mostly after ingestion of undercooked meat from infected animals. most hev 3 and 4 infections are clinically inapparent. however, genotype 3 (hev 3) can lead to chronic hepatitis in immuno-compromised patients such as organ-transplant recipients and patients with haemato ... | 2014 | 25267201 |
| lack of persistent hepatitis e virus infection as a cause for unexplained transaminase elevation in renal transplant recipients in india. | hepatitis e virus (hev) infection is highly endemic in india, being the most common cause of acute hepatitis; however, no case of chronic infection has been reported. all the human isolates of hev from india till date have belonged to genotype 1. in contrast, in non-endemic areas, genotype 3 is the most prevalent, and persistent hev infection has been reported among solid-organ transplant recipients. whether persistent infection occurs with genotype 1 hev is unclear. we therefore looked for evid ... | 2014 | 25266354 |
| chlorine inactivation of hepatitis e virus and human adenovirus 2 in water. | hepatitis e virus (hev) is transmitted via the fecal-oral route and has been recognized as a common source of large waterborne outbreaks involving contaminated water in developing countries. thus, there is the need to produce experimental data on the disinfection kinetics of hev by chlorine in water samples with diverse levels of fecal contamination. here, the inactivation of hev and human adenovirus c serotype 2 (hadv2), used as a reference virus, was monitored using immunofluorescence and quan ... | 2014 | 25252347 |
| prevalence of hepatitis e virus (hev) antibodies in serbian blood donors. | hepatitis e virus (hev) infection is rarely reported in industrialized countries, but recent studies have revealed quite variable seroprevalence rates among european populations, including blood donors. in serbia, very limited data about hev seroprevalence are available. this study aimed to determine the prevalence of anti-hev igg antibodies and hev rna in the sera of volunteer blood donors in serbia. | 2014 | 25313610 |
| the impact of hepatitis e in the liver transplant setting. | hepatitis e virus (hev) infection has been identified as a cause of graft hepatitis in liver transplant recipients. the true frequency and clinical importance of hev infections after liver transplantations is a matter of debate. it is proposed that consumption of hev-contaminated undercooked meat is a main source for hev infections in developed countries--which might also account for some hepatitis e cases after organ transplantation. however, hev is also transmitted by transfusion of blood prod ... | 2014 | 25195557 |
| hepatitis e virus of subtype 3i in chronically infected kidney transplant recipients in southeastern france. | hepatitis e virus (hev) is a leading cause of waterborne acute hepatitis in developing countries. in europe, hev causes a zoonotic disease and is hyperendemic in southern france. four hev genotypes (1 to 4) have been defined, and the most used classification divides them into 24 subtypes. autochthonous european hev strains belong in majority to genotype 3. subtypes 3c, 3f, and 3e are representative of the hev diversity in france. hev causes chronic hepatitis in solid-organ transplant recipients ... | 2014 | 25187634 |
| genetic heterogeneity of swine hepatitis e virus isolates from yunnan province, china in 2011-2012. | hepatitis e is a disease of major public-health concern mainly in developing countries. although molecular and sero-epidemiological investigations of hev have been performed in many provinces in china, the epidemiological data from yunnan province are limited and genotypes are not be fully characterized. in this study the prevalence and characteristics of hepatitis e virus (hev) detected in pigs from yunnan province, china was evaluated. | 2014 | 25187005 |
| clinical profile, maternal and fetal outcomes of acute hepatitis e in pregnancy. | pregnant women are at increased risk of complications in hepatitis e virus (hev) infection, with the risk increasing as the pregnancy progresses, often leading to fulminant hepatic failure and adverse fetal outcome. | 2014 | 25184080 |
| a mutation in the hepatitis e virus rna polymerase promotes its replication and associates with ribavirin treatment failure in organ transplant recipients. | we analyzed blood samples collected from 15 patients with chronic hepatitis e who were recipients of solid-organ transplants. all patients cleared the hepatitis e virus (hev) except for 2 (nonresponders); 1 patient died. a g1634r mutation in viral polymerase was detected in the hev rna of the nonresponders; this mutation did not provide the virus with resistance to ribavirin in vitro. however, the mutant form of a subgenomic replicon of genotype 3 hev replicated more efficiently in vitro than he ... | 2014 | 25181691 |
| hepatitis e in australian hiv-infected patients: an under-recognised pathogen? | background hepatitis e virus (hev) infection has been found to cause chronic hepatitis in hiv-infected patients. in australia, where hev is nonendemic, background seroprevalence is reportedly low but has not been evaluated in the hiv-infected population. the study aimed to assess the seroprevalence of hev in a cohort of hiv-infected patients with normal liver function and in another group with biochemical hepatitis. | 2014 | 25162285 |
| pork consumption and seroprevalence of hepatitis e virus,thailand, 2007-2008. | the nationwide seroprevalence of hepatitis e igg was determined among young men in thailand. overall seroprevalence was 14% (95% ci 13%-15%); range by province was 3%-26%. seroprevalence was lowest in the south, an area predominantly occupied by persons of the islam religion, whose dietary laws proscribe pork. | 2014 | 25148245 |
| early-life hepatitis e infection in pigs: the importance of maternally-derived antibodies. | passive immunity (pi), acquired through colostrum intake, is essential for piglet protection against pathogens. maternally-derived antibodies (mdas) can decrease the transmission of pathogens between individuals by reducing shedding from infected animals and/or susceptibility of naïve animals. only a limited number of studies, however, have been carried out to quantify the level of protection conferred by pi in terms of transmission. in the present study, an original modeling framework was desig ... | 2014 | 25144763 |
| crystal structure of a nematode-infecting virus. | orsay, the first virus discovered to naturally infect caenorhabditis elegans or any nematode, has a bipartite, positive-sense rna genome. sequence analyses show that orsay is related to nodaviruses, but molecular characterizations of orsay reveal several unique features, such as the expression of a capsid-δ fusion protein and the use of an atg-independent mechanism for translation initiation. here we report the crystal structure of an orsay virus-like particle assembled from recombinant capsid p ... | 2014 | 25136116 |
| acute fulminant hepatitis e virus genotype 3e infection: description of the first case in europe. | hepatitis e virus (hev) is the most important causative agent of acute hepatitis in developing countries. the disease is usually characterized by a self-limiting, benign course. however, when particular conditions coexist (pregnancy, old age, pre-existing liver disease) it may run an unfavourable course. to date, 4 hev genotypes have been described. historically, in the western world, hev infection was considered a travel-related disease, however in the last 2 decades a great number of non-trave ... | 2014 | 25134653 |
| safety measures to prevent hepatitis e virus transmission by blood transfusion. | 2014 | 25130335 | |
| mode of swine hepatitis e virus infection and replication in primary human hepatocytes. | the aim of this study was to investigate the infection and replication of swine-derived hepatitis e virus (hev) in primary cultured human hepatocytes (phcs). hepatocytes were cultured from the resected normal livers of patients with metastatic tumours. these cultured hepatocytes were infected with swine-derived genotype 3 or 4 hev. viral replication was monitored using reverse transcriptase-quantitative pcr. the amount of hev rna increased in the culture media and cells following infection. immu ... | 2014 | 25114028 |
| hepatitis e virus inhibits type i interferon induction by orf1 products. | hepatitis e virus (hev) causes both endemic and epidemic human hepatitis by fecal-oral transmission in many parts of the world. zoonotic transmission of hev from animals to humans has been reported. due to the lack of an efficient cell culture system, the molecular mechanisms of hev infection remain largely unknown. in this study, we found that hev replication in hepatoma cells inhibited poly(i·c)-induced beta interferon (ifn-β) expression and that the hev open reading frame 1 (orf1) product was ... | 2014 | 25100852 |
| characterization of the polyproline region of the hepatitis e virus in immunocompromised patients. | little is known about virus adaptation in immunocompromised patients with chronic genotype 3 hepatitis e virus (hev3) infections. virus-host recombinant strains have been isolated recently from chronically infected patients. the nature and incidence of such recombinant events occurring during infections of solid-organ transplant (sot) recipients are essentially unknown. the polyproline region (ppr) of strains isolated from sot patients was sequenced during the acute-infection phase (n = 59) and ... | 2014 | 25100839 |
| novel molecular alterations in the orf 2 capsid gene of hepatitis e virus in patients with acute liver failure in north india. | hepatitis e virus (hev) is evolving as a major global threat to public health, including in developed countries. we partially sequenced the orf 2 capsid protein genes of hev genomes from patients with acute liver failure, including pregnant women in the northern part of india. five unique synonymous substitutions and one non-synonymous substitution, along with a novel mutation, p259s, in the capsid gene, were identified that might be associated with the poor outcome in the patients. phylogenetic ... | 2014 | 25100237 |
| hepatitis e virus in blood components: a prevalence and transmission study in southeast england. | the prevalence of hepatitis e virus (hev) genotype 3 infections in the english population (including blood donors) is unknown, but is probably widespread, and the virus has been detected in pooled plasma products. hev-infected donors have been retrospectively identified through investigation of reported cases of possible transfusion-transmitted hepatitis e. the frequency of hev transmission by transfusion and its outcome remains unknown. we report the prevalence of hev rna in blood donations, th ... | 2014 | 25078306 |
| hepatitis e virus infection in farmed rabbits and swine in the eastern chinese city lianyungang: showing no potential interspecies transmission. | rabbit hev isolated recently from farmed rabbits in china has been shown experimentally to be able to infect both cynomolgus macaques and pigs. the purpose of the present study was to investigate the extent to which cross-species transmission of rabbit hev in farm settings is a significant factor in the spread of this zoonotic infection. rabbit and swine feces were collected from the same area in eastern china (lianyungang city) and analyzed by rt-pcr. partial genome sequencing of a 365 bp regio ... | 2014 | 25069969 |
| hepeviridae: an expanding family of vertebrate viruses. | the hepatitis e virus (hev) was first identified in 1990, although hepatitis e-like diseases in humans have been recorded for a long time dating back to the 18th century. the hev genotypes 1-4 have been subsequently detected in human hepatitis e cases with different geographical distribution and different modes of transmission. genotypes 3 and 4 have been identified in parallel in pigs, wild boars and other animal species and their zoonotic potential has been confirmed. until 2010, these genotyp ... | 2014 | 25050488 |
| mtor-inhibitors may aggravate chronic hepatitis e. | 2014 | 25046849 | |
| hepatitis e genotype 4 virus from feces of monkeys infected experimentally can be cultured in plc/prf/5 cells and upregulate host interferon-inducible genes. | the understanding of the interaction between hepatitis e virus (hev) and its host cells has been impeded greatly by the absence of a cell culture system. in this study, an efficient cultivation method was developed in plc/prf/5 cells for hev genotype 4 from the feces of monkeys infected experimentally. compared to minimal essential medium (mem), mixed dulbecco's modified eagle's medium (dmem)/m199 improved the infection efficiency of hev in plc/prf/5 cells. the incubation time and temperature we ... | 2014 | 25042677 |
| consensus proposals for classification of the family hepeviridae. | the family hepeviridae consists of positive-stranded rna viruses that infect a wide range of mammalian species, as well as chickens and trout. a subset of these viruses infects humans and can cause a self-limiting acute hepatitis that may become chronic in immunosuppressed individuals. current published descriptions of the taxonomical divisions within the family hepeviridae are contradictory in relation to the assignment of species and genotypes. through analysis of existing sequence information ... | 2014 | 24989172 |
| consensus proposals for classification of the family hepeviridae. | the family hepeviridae consists of positive-stranded rna viruses that infect a wide range of mammalian species, as well as chickens and trout. a subset of these viruses infects humans and can cause a self-limiting acute hepatitis that may become chronic in immunosuppressed individuals. current published descriptions of the taxonomical divisions within the family hepeviridae are contradictory in relation to the assignment of species and genotypes. through analysis of existing sequence information ... | 2014 | 24989172 |
| occurrence of hepatitis e virus infection in acute hepatitis in thailand. | hepatitis e virus (hev) infection is one of the enterically transmitted types of hepatitis. the present study was undertaken to estimate the occurrence of hev infection in sporadic acute hepatitis in thailand. serum samples were obtained from 614 suspected acute hepatitis patients at two large hospitals in bangkok during 2008, 2009, and 2011. acute hepatitis e was identified by the presence of anti-hev igm (4.8%) using indirect elisa kits and/or hev rna (4.5%) by a semi-nested reverse transcript ... | 2014 | 24984976 |
| assessment of airborne virus contamination in wastewater treatment plants. | occupational exposure to bioaerosols in wastewater treatment plants (wwtp) and its consequence on workers' health are well documented. most studies were devoted to enumerating and identifying cultivable bacteria and fungi, as well as measuring concentrations of airborne endotoxins, as these are the main health-related factors found in wwtp. surprisingly, very few studies have investigated the presence and concentrations of airborne virus in wwtp. however, many enteric viruses are present in wast ... | 2014 | 24981824 |
| hepatitis e virus seroprevalence among blood donors in jiangsu province, east china. | hepatitis e virus (hev) infection is responsible for over 50% of acute viral hepatitis cases, and the blood transfusion route has emerged as a possible means of sporadic hev infection. the aim of this study was to determine the seroprevalence of hev among blood donors in east china. | 2014 | 24981426 |
| incidence and natural history of hepatitis e virus coinfection among hiv-infected patients. | to know the prevalence, incidence and factors associated with hepatitis e virus (hev) infection in hiv-infected individuals in spain, as well as to provide information on the natural history of hiv/hev coinfection. | 2014 | 24979724 |
| hepatitis e virus infection in hematopoietic stem cell transplant recipients. | recipients of allogeneic stem cell transplantations are at risk of acquiring acute hepatitis e virus (hev) infection, leading to chronicity. we review the incidence, sequela, extrahepatic manifestations, and treatment of hepatitis due to hev infection in allogeneic hematopoietic stem cell transplantation (allohsct) recipients. | 2014 | 24977683 |