Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| prevalence of vitamin d insufficiency in obese children and adolescents. | recent studies have shown a broad prevalence of vitamin d deficiency in adults. serum 25-hydroxyvitamin d (25-ohd) levels were reported to be inversely related to body mass index (bmi) and body fat content and correlated directly with hypertension, degree of insulin resistance and progression to diabetes mellitus. we sought to determine the prevalence of vitamin d insufficiency and markers of metabolic syndrome in an obese pediatric population. | 2007 | 17849744 |
| mucinous rectal adenocarcinoma can be associated to tumor downstaging after preoperative chemoradiotherapy. | the aim of this study was to evaluate downstaging as primary end point, and progression-free survival and overall survival as secondary end points, in rectal adenocarcinoma patients treated with preoperative chemoradiation. | 2007 | 17846841 |
| [radiotherapy after radical prostatectomy: description, outcome and prognostic factors in and emerging practice]. | recently it has been reported in the eortc (european organisation for research and treatment of cancer) trial 22911 and the swog (southwest oncology group) 8794, the evidence that radiotherapy (rt) is an effective treatment after the prostatectomy in patients with high risk of biochemical failure. we analyze predictor factors of biochemical relapse and the potential benefits induced by rescue treatment are the main purposes of our study. | 2007 | 17847737 |
| effect of semen collection frequency on seasonal variation in sexual behaviour, testosterone, testicular size and semen characteristics of tropical hair rams (ovis aries). | the purpose of this study was to examine the effect of day length on seminal characteristics, testicular size, sexual behaviour and testosterone (t4) concentration in pelibuey rams subjected to different semen collection frequencies. eighteen intact males were assigned randomly to one of two semen collection frequencies: in the high rate (hr) treatment, two ejaculations per week were obtained from each ram; one ejaculation every two weeks was collected under the low rate (lr) treatment. all anim ... | 2007 | 17847822 |
| intensity-modulated radiation therapy in the treatment of head and neck cancer involving the base of the skull. | tumors invading the skull base pose a difficult problem for the treating radiation oncologist. when confronting these highly complex tumors where the gross tumor abuts the optic apparatus or brain stem, the physician often has to make a difficult choice regarding coverage of the tumor, i.e., underdosing portions of the tumor to protect the critical normal tissues versus accepting the risk of late complication while ensuring full coverage of the tumor. this situation is often encountered in advan ... | 2007 | 17848292 |
| carbamazepine and risk of hypothyroidism: a prospective study. | objectives - while carbamazepine (cbz) decreases thyroid hormone concentrations it rarely causes hypothyroidism. we assessed prospectively the early effect of cbz on thyroid status in thyroxine-supplemented hypothyroid patients, when compared with patients without a thyroid disorder. methods - in 29 patients, thyrotropin (tsh), total thyroxine (tt4) and free thyroxine (ft4) serum levels were assayed before starting cbz, and then weekly for 7 weeks. nineteen patients with no thyroid disorder (gro ... | 2007 | 17850408 |
| periodontopathic microorganisms in peripheric blood after scaling and root planing. | the objective of this study was to evaluate the frequency of periodontopathic and other subgingival anaerobic and facultative bacteria in the bloodstream following scaling and root planing (srp). | 2007 | 17850606 |
| cryo-em study of the pseudomonas bacteriophage phikz. | the phikz virus is one of the largest known bacteriophages. it infects pseudomonas aeruginosa, which is frequently pathogenic in humans, and, therefore, has potential for phage therapy. the phikz virion consists of an approximately 1450 a diameter icosahedral head and an approximately 2000 a long contractile tail. the structure of the phikz tail has been determined using cryo-electron microscopy. the phikz tail is much longer than that of bacteriophage t4. however, the helical parameters of thei ... | 2007 | 17850749 |
| [c-fos protein expression in the parietal cortex and olfactory tubercle in the hypoxic rat brain]. | we have attempted to identify which parts of the brain react to ischemic attack using the four-vessel occlusion model in rats. | 2007 | 17853723 |
| ["is my brother's life in the institution still safe? or one day he gets "pneumonia" (...) and we get the urn???)" [1]--the relatives of institution patients during national-socialism patient killing action "t4"]. | 2007 | 17853785 | |
| thymidylate synthase and thymidine phosphorylase gene expression as predictive parameters for the efficacy of 5-fluorouracil-based adjuvant chemotherapy for gastric cancer. | to investigate the prognostic role of thymidylate synthase (ts) and thymidine phosphorylase (tp) mrna levels in t3 or t4 gastric cancer treated with 5-fluorouracil-based adjuvant chemotherapy. | 2007 | 17854149 |
| phase i trial of neoadjuvant preoperative chemotherapy with s-1 and irinotecan plus radiation in patients with locally advanced rectal cancer. | to determine the maximum tolerated dose (mtd) and recommended dose (rd) of irinotecan combined with preoperative chemoradiotherapy with s-1 in patients with locally advanced rectal cancer. | 2007 | 17855009 |
| type vi secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin. | genes encoding type vi secretion systems (t6ss) are widely distributed in pathogenic gram-negative bacterial species. in vibrio cholerae, t6ss have been found to secrete three related proteins extracellularly, vgrg-1, vgrg-2, and vgrg-3. vgrg-1 can covalently cross-link actin in vitro, and this activity was used to demonstrate that v. cholerae can translocate vgrg-1 into macrophages by a t6ss-dependent mechanism. protein structure search algorithms predict that vgrg-related proteins likely assem ... | 2007 | 17873062 |
| special treatment issues in lung cancer: accp evidence-based clinical practice guidelines (2nd edition). | this chapter of the guidelines addresses patients who have particular forms of non-small cell lung cancer that require special considerations. this includes patients with pancoast tumors, t4n0,1m0 tumors, satellite nodules in the same lobe, synchronous and metachronous multiple primary lung cancers (mplcs), solitary brain and adrenal metastases, and chest wall involvement. | 2007 | 17873175 |
| hypothyroidism and hyperthyroidism modulates ras-mapk intracellular pathway in rat thyroids. | thyrotrophin induces proliferation and function in thyroid cells acting through a seven transmembrane g protein-coupled receptor. the proliferative pathways induced by thyrotropin (tsh) in thyrocytes in vivo are not completely understood yet. the aim of this work is to evaluate if ras can be induced by tsh in rat thyroids, and whether extracellular regulated kinase (erk) may be involved in the subsequent intracellular signalling cascade. we induced hypothyroidism in wistar rats by methimazole (m ... | 2007 | 17873330 |
| effects of selenium and tellurium on the activity of selenoenzymes glutathione peroxidase and type i iodothyronine deiodinase, trace element thyroid level, and thyroid hormone status in rats. | tellurium (te) and selenium (se) belong chemically to the via group of elements. se represents an essential element closely related to thyroid function. te has growing application in industrial processes. little is known about the te biological activity, particularly with respect to potential chemical interactions with se-containing components in the organism. in this study, female wistar rats (body weight: 115-120 g) received sodium selenite pentahydrate (10 mg/l) or sodium tellurite (9.4 mg/l) ... | 2007 | 17873396 |
| oncological results of surgical treatment of malignant tumors of the nasal vestibule. | we evaluated functional results of surgical treatment for squamous cell carcinoma of the nasal vestibule. | 2007 | 17873502 |
| crystal structure of t4 endonuclease vii resolving a holliday junction. | holliday proposed a four-way dna junction as an intermediate in homologous recombination, and such holliday junctions have since been identified as a central component in dna recombination and repair. phage t4 endonuclease vii (endo vii) was the first enzyme shown to resolve holliday junctions into duplex dnas by introducing symmetrical nicks in equivalent strands. several holliday junction resolvases have since been characterized, but an atomic structure of a resolvase complex with a holliday j ... | 2007 | 17873859 |
| in vitro glucuronidation of thyroxine and triiodothyronine by liver microsomes and recombinant human udp-glucuronosyltransferases. | glucuronidation, which may take place on the phenolic hydroxyl and carboxyl groups, is a major pathway of metabolism for thyroxine (t4) and triiodothyronine (t3). in this study, a liquid chromatography/mass spectrometry (lc/ms) method was developed to separate phenolic and acyl glucuronides of t4 and t3. the method was used to collect the phenolic glucuronide of t4 for definitive characterization by nmr and to determine effects of incubation ph, species differences, and human udp-glucuronosyltra ... | 2007 | 17875670 |
| dosimetric comparison between coplanar and non coplanar field radiotherapy for ethmoid sinus cancer. | to compare non coplanar field (ncf) with coplanar field (cf) -intensity-modulated radiotherapy (imrt) planning for ethmoid cancer. | 2007 | 17877793 |
| crystallographic and nmr analyses of uvsw and uvsw.1 from bacteriophage t4. | the uvswxy system is implicated in the replication and repair of the bacteriophage t4 genome. whereas the roles of the recombinase (uvsx) and the recombination mediator protein (uvsy) are known, the precise role of uvsw is unclear. sequence analysis identifies uvsw as a member of the monomeric sf2 helicase superfamily that translocates nucleic acid substrates via the action of two reca-like motor domains. functional homologies to escherichia coli recg and biochemical analyses have shown that uvs ... | 2007 | 17878153 |
| the effect of changes in the bulk dielectric constant on the dna torsional properties. | the effect of changes in the bulk dielectric constant on the dna torsional properties was evaluated from plasmid circularization reactions. in these reactions, puc18 previously linearized by ecori digestion was recircularized with t4 dna ligase. the bulk dielectric constant of the reaction medium was decreased by the addition of different concentrations of neutral solutes: ethylene glycol, glycerol, sorbitol, and sucrose, or increased by the addition of glycine. the topoisomers generated by the ... | 2007 | 17879331 |
| rectal cancer: incidence of pulmonary metastases on thoracic ct and correlation with t staging. | the aim of the study was to evaluate the incidence of pulmonary metastases detected on thoracic computed tomography in patients with rectal cancer and assess the association between the incidence of pulmonary metastases and the stage of the rectal tumor. | 2007 | 17882033 |
| [cervical lymph node metastasis of pyriform sinus carcinoma]. | to investigate the characteristic of cervical lymph node metastasis of pyriform sinus carcinoma. | 2007 | 17882971 |
| assessment of the factors involving in the development of hypothyroidism in hiv-infected patients: a case-control study. | increased prevalence of thyroid dysfunction has been reported in hiv-infected patients, and recent studies have shown hypothyroidism as the most common thyroid function abnormality in this population, especially after treatment with antiretroviral drugs (haart). the aim of this study is to assess risk factors of hypothyroidism in hiv-infected patients in iran. | 2007 | 17885731 |
| integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation. | during endochondral bone formation, chondrocytes undergo a process of terminal differentiation or maturation, during which the rate of proliferation decreases, cells become hypertrophic, and the extracellular matrix is altered by production of a unique protein, collagen x, as well as proteins that promote mineralization. the matrix surrounding the hypertrophic chondrocytes eventually becomes mineralized, and the mineralized matrix serves as a template for bone deposition. this process is respons ... | 2007 | 17886256 |
| direct equilibrium dialysis compared with two non-dialysis free t4 methods in premature infants. | to compare the incidence of low free t4 values reported by a direct equilibrium dialysis method to their incidence reported by 2 non-dialysis methods. | 2007 | 17889078 |
| detrended fluctuation analysis of resting eeg in depressed outpatients and healthy controls. | recent findings have demonstrated that the eeg possesses long-range temporal (auto-) correlations (lrtc) in the dynamics of broad band oscillations. the analysis of lrtc provides a quantitative index of statistical dependencies in oscillations on different time scales. we analyzed lrtc in resting eeg signals in depressed outpatients and healthy controls. | 2007 | 17890151 |
| the nuclear pp1 interacting protein zap3 (zap) is a putative nucleoside kinase that complexes with sam68, cia, nf110/45, and hnrnp-g. | the targeting of protein kinases and phosphatases is fundamental to their roles as cellular regulators. the type one serine/threonine protein phosphatase (pp1) is enriched in the nucleus, yet few nuclear pp1 targeting subunits have been described and characterized. here we show that the human protein, zap3 (also known as zap), is localized to the nucleus, that it is expressed in all mammalian tissues examined, and docks to pp1 through an rvrw motif located in its highly conserved carboxy-terminu ... | 2007 | 17890166 |
| [recombinant human tsh use in differentiated thyroid cancer]. | traditionally, the immediate treatment of patients with differentiated thyroid carcinoma (dtc) after total thyroidectomy (tt) is thyroid remnant ablation (tra) with 131i, during hypothyroidism. late follow-up of dct includes suppressive doses of t4, serial measurements of thyroglobulin (tg), whole body scan (wbs) with 131i and cervical ultrasound (us). in the last years, tra with the aid of recombinant human tsh (rhtsh) has shown not only to avoid symptoms of hypothyroidism and a lower quality o ... | 2007 | 17891244 |
| [clinical repercussion of the 6th edition tnm staging system classification on differentiated thyroid carcinoma]. | the tnm classification of uicc is used for predicting the outcome of thyroid cancer. the 6th edition changed the description of primary tumor (t), regional lymph node (n) and the staging group. the aim of this study was to compare the ability of the 5th and the 6th editions to predict outcome. the two classifications were applied in a retrospective analysis of 90 patients from hucff. sixty-nine patients had papillary carcinoma, 14 follicular, 4 hürthle cell, and 3 mixed. patients were followed f ... | 2007 | 17891247 |
| [will the thyroglobulin assay with lower functional sensitivity whilst the patients are on l-t4 treatment replace the tsh-stimulated thyroglobulin assay in the follow-up of patients with differentiated thyroid cancer?]. | the author reviews the literature on the new assays for serum thyroglobulin (stg) presenting lower functional sensitivity and demonstrates that its use, whilst the patients are taking l-t4, presents better results than stg following tsh stimulation in the follow-up of patients with differentiated thyroid carcinoma. therefore, he suggests a revision on the guidelines for the follow-up of these patients (developed when the available assays present a sensitivity of 1 ng/ml), proposing the use of st ... | 2007 | 17891252 |
| a role of rnla in the rnase ls activity from escherichia coli. | escherichia coli ribonuclease ls is a potential antagonist of bacteriophage t4. when the t4 dmd gene is defective, rnase ls cleaves t4 mrnas and antagonizes t4 reproduction. our previous work demonstrated that e. coli rnla is essential for rnase ls activity. here we show that his-tagged rnla cleaves t4 soc rna at one of the sites also cleaved by rnase ls in a cell extract. the cleavage activities of his-tagged rnla and the rnase ls activity in a cell extract were inhibited by dmd encoded by t4 p ... | 2007 | 17895580 |
| [mosaic expression pattern of the nptii gene in transgenic tobacco plants nu 21]. | mosaic expression pattern of the nptii gene in transgenic tobacco nu 21 leaf somatic cells was demonstrated. inheritance of this phenotype (in t1-t4 and f1 backcrosses) was revealed. three plant groups were distinguished, with low frequency of variegation manifestation (0-21.8%), with the high frequency of mosaic progeny (63.1 to 100%), and the intermediate type, where the frequency of the appearance of mosaic plants varied in a wide range, from 0 to 100%. the data obtained suggested the existen ... | 2007 | 17899813 |
| rz/rz1 lysis gene equivalents in phages of gram-negative hosts. | under usual laboratory conditions, lysis by bacteriophage lambda requires only the holin and endolysin genes, but not the rz and rz1 genes, of the lysis cassette. defects in rz or rz1 block lysis only in the presence of high concentrations of divalent cations. the lambda rz and rz1 lysis genes are remarkable in that rz1, encoding an outer membrane lipoprotein, is completely embedded in the +1 register within rz, which itself encodes an integral inner membrane protein. while rz and rz1 equivalent ... | 2007 | 17900620 |
| electrophysiological analysis of a sensorimotor integration task. | the present experiment aimed at investigating electrophysiologic changes observed as beta band asymmetry, by quantitative electroencephalography (qeeg), when individuals performed a reaching motor task (catching a ball in free fall). the sample was composed of 23 healthy individuals, of both sexes, with ages varying between 25 and 40 years old. all the subjects were right handed. a two-way anova was applied for the statistical analysis, to verify the interaction between task moment (i.e., 2s bef ... | 2007 | 17900806 |
| prevention of atrial fibrillation after coronary artery bypass graft surgery using a potassium-magnesium-aspartate solution (inzolen). | atrial fibrillation (afib) following cardiac surgery is a frequent complication. the purpose of this study was to evaluate the efficacy of a potassium-magnesium-aspartate solution (inzolen) for the prevention of afib. | 2007 | 17902062 |
| gastric carcinoma: typing, staging, lymph node and resection margin status on gastrectomy specimens. | objective: to determine the extent and stage of gastric carcinoma on gastrectomy specimens in terms of type, grade, location, depth of invasion, resection margins and lymph node status. study design: descriptive study. place and duration of study: section of histopathology, department of pathology, aga khan university, karachi during 2005 and 2006. materials and methods: a 100 consecutive gastrectomy specimens received during the study period, in which resection was done for gastric carcinoma we ... | 2007 | 17903401 |
| patterns of relapse in locally advanced breast cancer treated with neoadjuvant chemotherapy followed by surgery and radiotherapy. | to define the clinical and pathological predictors of locoregional recurrence (lrr) in locally advanced breast cancer (labc) patients treated with neoadjuvant chemotherapy (nact). | 2007 | 17998727 |
| a prospective study evaluating surgery and chemo radiation in muscle invasive bladder cancer. | the aim of our study was to compare the two standard treatment approaches in muscle invasive carcinoma of urinary bladder--radical cystectomy and chemo radiation. | 2007 | 17998728 |
| impact of systemic hypoxemia on cancer aggressiveness and circulating vascular endothelial growth factors a and c in gastroesophageal cancer patients with chronic respiratory insufficiency. | due to the common etiologic factor, a considerable number of esophagogastric cancer patients suffer from respiratory insufficiency in course of chronic obstructive pulmonary disease, primary to cancer. systemic hypoxemia may account for poor oxygenation of tumor tissue-a main driving force of tumor neoangiogenesis. we hypothesized that in cancer patients with respiratory insufficiency, systemic hypoxemia may be related to enhanced aggressiveness of cancer on one side and to the elevation of angi ... | 2007 | 18004252 |
| optimal organ-sparing intensity-modulated radiation therapy (imrt) regimen for the treatment of locally advanced anal canal carcinoma: a comparison of conventional and imrt plans. | to compare the dosimetric advantage of three different intensity-modulated radiation therapy (imrt) plans to a three dimensional (3d) conventional radiation treatment for anal cancer with regards to organs-at-risk (oar) avoidance, including iliac bone marrow. | 2007 | 18005443 |
| [outline of general rules for the description of thyroid cancer (6th edition)]. | general rules for the description of thyroid tumors is essential for the medical practice on thyroid tumors. the japanese society of thyroid surgery has published the general rules since 1977, and has revised it 5 times according to the revision of uicc tnm classification or who histological classification by the latest 6th edition of the rules published in 2005. in the present revision of the rules tnm and ex (extra thyroidal invasion) classifications were reconsidered as compared with uicc tnm ... | 2007 | 18018553 |
| [our surgical strategy for thyroid carcinoma]. | according to our previous data on papillary thyroid cancer (ptc), recurrences are related to lymph node ratio (number of metastatic lymph nodes/number of dissected nodes) and lymphatic spread of ptc is more symmetrical than previously thought. therefore, neck dissection should be performed symmetrically. our basic procedure for clinically evident ptc is total thyroidectomy with central neck dissection. for the cases with jugular chain adenopathy and/or t3, t4 tumor, bilateral lateral neck dissec ... | 2007 | 18018566 |
| [changes in plasma concentrations of osteoprotegerin before and after levothyroxine replacement therapy in hypothyroid patients]. | to investigate the alteration of plasma osteoprotegerin (opg) concentration before and after levothyroxine (l-t4) replacement therapy and its association with endothelium-dependent arterial dilation in patients with overt hypothyroidism (oht) and subclinical hypothyroidism (sht). | 2007 | 17988532 |
| pseudomalabsorption of thyroid hormones: case report and review of the literature. | many causes of thyroxine malabsorption are described in the literature, but the most common cause of failure of thyroxine therapy is poor patient compliance, or pseudomalabsorption. we describe the case of a female patient who underwent total thyroidectomy for basedow-graves disease. post-operatively, several treatment regimens were employed to achieve euthyroidism, but only injectable thyroxine was found to be effective. to exclude levothyroxine malabsorption, the patient was hospitalized in a ... | 2007 | 17988645 |
| technique and clinical results of minimally invasive reconstruction and stabilization of the thoracic and thoracolumbar spine with expandable cages and ventrolateral plate fixation. | to evaluate the techniques of minimally invasive single- and multilevel corpectomy and reconstruction of the thoracic and thoracolumbar spine using expandable vertebral body replacement (vbr) cages and ventrolateral plate fixation (vpf) via anterolateral retropleural (alra) and combined thoracoabdominal approaches. | 2007 | 17986942 |
| geometry-based sampling of conformational transitions in proteins. | the fast and accurate prediction of protein flexibility is one of the major challenges in protein science. enzyme activity, signal transduction, and ligand binding are dynamic processes involving essential conformational changes ranging from small side chain fluctuations to reorientations of entire domains. in the present work, we describe a reimplementation of the concoord approach, termed tconcoord, which allows a computationally efficient sampling of conformational transitions of a protein ba ... | 2007 | 17997973 |
| multicentric epithelioid angiosarcoma of the spine: a case report of a rare bone tumor. | epithelioid angiosarcoma (ea) is a high-grade sarcoma of vascular origin. ea is a rare variant of angiosarcoma. it is characterized by large cells with an epethelioid morphology. ea has been reported in sites like skin thyroid, adrenal gland, soft tissue, and rarely in bone. | 2007 | 17998131 |
| cardiovascular assessment of hyperthyroid patients with multinodular goiter before and after radioiodine treatment preceded by stimulation with recombinant human tsh. | treatment of large multinodular goiter (mng) with radioiodine preceded by recombinant human thyrotropin (0.1 mg rhtsh) has been shown to be a safe alternative for patients with comorbidities that preclude surgery. however, the increase in serum thyroid hormones that follows both treatments may be harmful for some patients, particularly those with underlying cardiovascular disease. in this study, we evaluated cardiac parameters (clinical, ecg, 24-h holter, doppler echocardiogram, treadmill stress ... | 2007 | 18026694 |
| circumferential margin involvement is the crucial prognostic factor after multimodality treatment in patients with locally advanced rectal carcinoma. | after preoperative (radio)chemotherapy, histologic determinants for prognostication have changed. it is unclear which variables, including assessment of tumor regression, are the best indicators for local recurrence and survival. | 2007 | 18006762 |
| proximal junctional kyphosis in adolescent idiopathic scoliosis after 3 different types of posterior segmental spinal instrumentation and fusions: incidence and risk factor analysis of 410 cases. | retrospective study. | 2007 | 18007253 |
| comparison of enzymatic recognition of dna-duplexes containing no-induced lesions by dna-relevant enzymes. | nitric oxide (no) produced in inflamed tissues is known to cause dna damage by nitrosation or oxidation of base moieties. for investigating the biophysical and biochemical properties of dna lesions induced by nitric oxide, we prepared synthetic dna oligomers and analyzed melting temperature (t(m)) or enzymatic recognition of dna strands containing oxanine (oxa) and hypoxanthine (hyp), using guanine (gua) or adenine (ade) as control bases, respectively. for enzymatic reaction by dna-relevant enzy ... | 2007 | 18029781 |
| [visual search and event-related potentials in the extrastriate cortical areas in humans]. | parameters of visual search (reaction time, mistakes) were investigated in 11 young healthy volunteers, under changing parameters of target symbol (form, color and location) in surroundings of white distracters (flankers). in 6 cortical leads: p3, p4, t3, t4, t5, t6, monopolar event-related potentials (erps) were registered and analyzed for the late endogenous components: n2, p3, because these very components have changed under verifying of search (so called late selection). in the hard search ( ... | 2007 | 18030798 |
| a treatment planning analysis of inverse-planned and forward-planned intensity-modulated radiation therapy in nasopharyngeal carcinoma. | to compare dose-volume histograms of target volumes and organs at risk in 57 patients with nasopharyngeal carcinoma (npc) with inverse- (ip) or forward-planned (fp) intensity-modulated radiation treatment (imrt). | 2007 | 18035216 |
| [adenosine preconditioning reduces myocardial injury in patients undergoing off-pump coronary artery bypass grafting surgery]. | to evaluate the effects of adenosine on reducing myocardial injuries in patients undergoing off-pump coronary artery bypass grafting (opcab). | 2007 | 18036291 |
| semiquantitative rt-pcr measurement of gene expression in rat tissues including a correction for varying cell size and number. | abstract: | 2007 | 18039356 |
| monitoring of the sublingual microcirculation in cardiac surgery using orthogonal polarization spectral imaging: preliminary results. | the recent introduction of orthogonal polarization spectral imaging enables the direct visualization of the microcirculation of man without imaging enhancing dyes. the authors studied the changes in microvascular perfusion of sublingual mucosa during cardiac surgery with the use of cardiopulmonary bypass (cpb) using this optical method. | 2007 | 18043062 |
| prognostic significance of multiple molecular markers for patients with stage ii colorectal cancer undergoing curative resection. | the aim of this study was to determine whether our constructed high-sensitivity colorimetric membrane-array method could detect circulating tumor cells (ctcs) in the peripheral blood of stage ii colorectal cancer (crc) patients and so identify a subgroup of patients who are at high risk for relapse. | 2007 | 18043108 |
| comparison between 3-t magnetic resonance imaging and multi-detector row computed tomography for the preoperative evaluation of rectal cancer. | to compare prospectively between 3-t magnetic resonance imaging (mri) and multidetector row computed tomography (mdct) for the local staging of rectal cancer. | 2007 | 18043346 |
| feasibility of using interpolated contours of targets and organs at risk in intensity-modulated radiation therapy treatment planning for advanced-stage nasopharyngeal carcinoma. | to assess the dosimetric effect of using interpolated contours in planning intensity-modulated radiation therapy (imrt) for advanced t-stage nasopharyngeal carcinoma. the present study focused on t3-t4 tumours where the proximity of targets to neurological organs poses a stringent test on the feasibility of such an approach. contours of targets and organs were delineated on ct images of 2.5-mm interval and a reference imrt plan was generated. an investigative (inv) imrt plan was then generated w ... | 2007 | 17803802 |
| differential methylation kinetics of individual target site strands by t4dam dna methyltransferase. | prokaryote dna methyltransferases (mtases) of the dam family (including those of bacteriophages t2 and t4) catalyze methyl group transfer from s-adenosyl-l-methionine (adomet), producing s-adenosyl-l-homocysteine (adohcy) and methylated adenine residues in palindromic gatc sequences. dam dna mtases, as all site-specific enzymes interacting with polymeric dna, require a mechanism of action that ensures a rapid search for specific targets for catalytic action, during both the initial and subsequen ... | 2007 | 17976013 |
| effects of sub-chronic nitrate exposure on the thyroidal function in humans. | no experimental data exist on the thyroid toxicity of nitrate among humans. we aimed to show that no significant antithyroid effect could be observed after exposure to a three times the acceptable daily intake of nitrate in humans. in a randomized controlled non-inferiority trial, 10 volunteers received 15 mg/kg sodium nitrate during 28 days whereas 10 control participants received distilled water. we performed 5- and 24-h measurements of thyroidal (131)i uptake (raiu) before and at the end of t ... | 2007 | 17980977 |
| thyroid disease in patients with mccune-albright syndrome. | involvement of the thyroid gland in the mccune-albright syndrome (mas) is a common and sometimes overlooked feature of this disorder. the characteristics of the thyroid in mas include isolated or combinations of generalized inhomogeneity, cystic and/or nodular features coupled with functional abnormalities. while most often the pathology is diffuse, it is rarely associated with compressive symptoms and signs. the functional abnormalities, which are seldom observed in the absence of underlying ec ... | 2007 | 17982391 |
| 18f-fdg dual-headed gamma camera pet in detection of axillary nodal disease in patients with large or locally advanced breast cancer: possible alternative staging of axilla. | positron emission tomography (pet) has been used in staging the axilla. gamma camera pet (gcpet) is a cost effective alternative, but poorly studied. the aim of this study was to assess gcpet in demonstrating metastatic deposits in axillary nodes in patients with a high likelihood of nodal disease. twenty-seven women with large (t2, t3 or t4) or advanced breast cancer (n1, n2 or m1) were recruited. all patients underwent axillary lymph node removal or biopsy (fine needle aspiration cytology (fna ... | 2007 | 17982642 |
| enhancing the "a-rule" of translesion dna synthesis: promutagenic dna synthesis using modified nucleoside triphosphates. | abasic sites are mutagenic dna lesions formed as a consequence of inappropriate modifications to the functional groups present on purines and pyrimidines. in this paper we quantify the ability of the high-fidelity bacteriophage t4 dna polymerase to incorporate various promutagenic alkylated nucleotides opposite and beyond this class of non-instructional dna lesions. kinetic analyses reveal that modified nucleotides such as n6-methyl-datp and o6-methyl-dgtp are incorporated opposite an abasic sit ... | 2007 | 17983244 |
| metformin reduces thyrotropin levels in obese, diabetic women with primary hypothyroidism on thyroxine replacement therapy. | context it has been reported that metformin might modify thyroid hormone economy. in two retrospective studies, initiation of treatment with metformin caused suppression of tsh to subnormal levels. objective to prospectively evaluate if administration of metformin to obese, diabetic patients with primary hypothyroidism on stable thyroxine replacement doses modifies tsh levels. patients and methods eight obese, diabetic postmenopausal women with primary hypothyroidism participated in the study. t ... | 2007 | 17992605 |
| acute effects of leptin on 5'-deiodinases are modulated by thyroid state of fed rats. | leptin has been shown to modulate deiodinase type 1 (d1) and type 2 (d2) enzymes responsible for thyroxine (t4) to triiodothyronine (t3) conversion. previously, it was demonstrated that a single injection of leptin in euthyroid fed rats rapidly increased liver, pituitary, and thyroid d1 activity, and simultaneously decreased brown adipose tissue (bat) and hypothalamic d2 activity. we have now examined d1 and d2 activities, two hours after a single subcutaneous injection of leptin (8 microg/100 g ... | 2007 | 17992637 |
| [operation t4 or the implication of the german dental surgeons in the ideology of eugenics and the euthanasia of mental lunatics]. | many things have been said about the t4 operation and the sad role played by nazi doctors. but one could ask the same question about the dentists? they played an important role as they examined, diagnosed and denounciated patients with congenital diseases. their in-house training serving this purpose was very specialised. their implication is even more unquestionable when it came to removing dental gold from the mouth of the victims. once it was collected this gold contributed on a financial lev ... | 2007 | 17992835 |
| experimental neurotisation of the brachial plexus by means of nerve grafting from the corticospinal tract of the proximal spinal cord at the t3-t4 level. | this paper reports experimental work in rats in which the radial nerve was cut at its origin from the brachial plexus and connected by means of a nerve graft to the corticospinal tract of the spinal cord at the t3-t4 level. after surgery, the triceps and extensor muscles of the forearm were able to extend the elbow and the wrist and gave almost normal responses on emg. this reinnervation was no longer cholinergic, as demonstrated by the vecuronium test. because of the drawbacks associated with i ... | 2007 | 17993421 |
| concerted diffusion, clustering, and magnetic properties of mn dopants on a 2 x 2-t4 gan(0001) substrate. | based on first-principles calculations within density functional theory, we propose a kinetic pathway for mn incorporation on reconstructed 2 x 2-t4 gan(0001), characterized by concerted substitution of a ga atom by a mn adatom via a precursor surface site t4. the mn dopants at low densities are randomly distributed, resulting in intrinsic diluted magnetic semiconductors (dms). at high mn densities, planar ferromagnetic clusters oriented in the (0001) plane can be readily formed at relatively lo ... | 2007 | 17995269 |
| evolution of temperate pathogens: the bacteriophage/bacteria paradigm. | taking as a pattern, the t4 and lambda viruses interacting with each other and with their gram-negative host, escherichia coli, a general model is constructed for the evolution of 'gentle' or temperate pathogens. this model is not simply either pure group or kin selection, but probably is common in a variety of host-parasite pairs in various taxonomic groups. the proposed mechanism is that for its own benefit the pathogen evolved ways to protect its host from attack by other pathogens and this h ... | 2007 | 17996103 |
| comparative outcome between chemoradiotherapy and lateral pelvic lymph node dissection following total mesorectal excision in rectal cancer. | to evaluate comparative outcome between adjuvant postoperative chemoradiotherapy (postoperative crt) and lateral pelvic lymph node dissection (lpld) following total mesorectal excision (tme) in rectal cancer patients. | 2007 | 17968166 |
| enzymatic manipulations of dna oligonucleotides on microgel: towards development of dna-microgel bioassays. | we demonstrate that dna oligonucleotides covalently coupled to colloidal microgel can be manipulated by t4 dna ligase for dna ligation and by phi29 dna polymerase for rolling circle amplification (rca). we also show that the long single-stranded rca product can generate intensive fluorescence upon hybridization with complementary fluorescent dna probe. we believe dna-microgel conjugates can be explored for the development of dna based bioassays and biosensors. | 2007 | 17971955 |
| optimization of non-natural nucleotides for selective incorporation opposite damaged dna. | the promutagenic process known as translesion dna synthesis reflects the ability of a dna polymerase to misinsert a nucleotide opposite a damaged dna template. to study the underlying mechanism of nucleotide selection during this process, we quantified the incorporation of various non-natural nucleotide analogs opposite an abasic site, a non-templating dna lesion. our kinetic studies using the bacteriophage t4 dna polymerase reveal that the pi-electron surface area of the incoming nucleotide sub ... | 2007 | 17971991 |
| chronic leptin treatment inhibits liver mitochondrial alpha-glycerol-beta-phosphate dehydrogenase in euthyroid rats. | leptin modulates the hypothalamus-pituitary-thyroid axis and peripheral metabolism of thyroid hormones (ths). we have studied the effect of acute and chronic leptin treatment upon liver mitochondrial glycerol phosphate dehydrogenase activity (mgpd), whose expression and activity are th dependent. we performed 2 experiments: 1) acute leptin treatment - lepa: adult rats received a single leptin injection (8 microg/100 g bw); 2) chronic leptin treatment - lepc: adult rats received leptin (8 microg/ ... | 2007 | 17973206 |
| accurate prediction of enzyme mutant activity based on a multibody statistical potential. | an important area of research in biochemistry and molecular biology focuses on characterization of enzyme mutants. however, synthesis and analysis of experimental mutants is time consuming and expensive. we describe a machine-learning approach for inferring the activity levels of all unexplored single point mutants of an enzyme, based on a training set of such mutants with experimentally measured activity. | 2007 | 17977887 |
| detection of four adenovirus serotypes within water-isolated strains of acanthamoeba in the canary islands, spain. | we surveyed 236 potentially pathogenic acanthamoeba strains, isolated from water sources in the canary islands, for the presence of human adenoviruses (hadv) using a polymerase chain reaction (pcr)-based typing assay. a total of 34 of these strains were found to be positive for adenovirus belonging to four different hadv serotypes (hadv-1, 2, 8, and 37). we found that hadv-2 was the most frequently encountered serotype amongst the acanthamoeba strains, and their identification was confirmed by a ... | 2007 | 17978083 |
| traction versus supine side-bending radiographs in determining flexibility: what factors influence these techniques? | prospective clinical, radiologic study of adolescent idiopathic scoliosis (ais). | 2007 | 17978661 |
| factors related to survival from oral cancer in an andalusian population sample (spain). | approximately 3% of malignant tumors originate in the oral cavity. the majority are squamous cell carcinomas, and a small percentage, malignant tumors of the salivary glands, lymphoreticular diseases, bone tumors, melanomas, sarcomas, malignant odontogenic tumors and metastases of tumors from other locations. the prognosis of these pathologies depends on the size, infiltration, and site of the lesion, the presence or absence of metastatic spread, and to a certain degree the differentiation of th ... | 2007 | 17978776 |
| effects of an acute treatment with l-thyroxine on memory, habituation, danger avoidance, and on na+, k+ -atpase activity in rat brain. | thyroid hormones (ths) have a relevant action on brain development and maintenance. by using an acute treatment to induce a hyperthyroid animal model, we aimed at investigating the effect of an altered ths levels on learning and memory and on the activity of na(+), k(+)-atpase in the rat brain. our results have shown that the acute treatment with l-t4 did not alter the retrieval of the inhibitory avoidance task, but had a significant effect on the elevated plus maze and on open-field performance ... | 2007 | 18045151 |
| thyroid function and volume in epileptic children using carbamazepine, oxcarbazepine and valproate. | the aim of the present study was to investigate the effects of carbamazepine (cbz), oxcarbazepine (oxc), and valproic acid (vpa) on thyroid function and volume in epileptic children. | 2007 | 18045279 |
| third degree atrioventricular block and accelerated idioventricular rhythm associated with a heart base chemodectoma in a syncopal rottweiler. | a 7-year-old male intact rottweiler was presented with a 1-week history of lethargy, anorexia, vomiting and multiple syncopal events. the results of the clinical examination and electrocardiography were consistent with a third degree atrioventricular block and an intermittent accelerated idioventricular rhythm. haematology, serum biochemistry, serology for borrelia burgdorferi, blood culture, total t4, thoracic radiography and echocardiography did not reveal the cause of the arrhythmia. response ... | 2007 | 18045349 |
| modified cold pressor test by cold application to the foot after spinal cord injury: suggestion of hemodynamic control by the spinal cord. | study hemodynamic responses to cold application to the foot (caf) to explore the autonomic cardiovascular control by the spinal cord. | 2007 | 18049135 |
| adjuvant chemotherapy for stage ii colon cancer: influence of care structures' characteristics on a controversial clinical practice. | adjuvant chemotherapy for stage ii colon cancer is a controversial practice and is not recommended by the french consensus conference outside of therapeutic trial. | 2007 | 18049170 |
| [radiotherapy of rectal cancer]. | of the approximately 1,100 new cases of rectal cancer in norway annually, many can be cured by surgery alone, but a large group of patients need supplemental treatment. we here present the national consensus for radiotherapy of rectal cancer. | 2007 | 18049501 |
| development of a novel vector system for programmed cell lysis in escherichia coli. | although widely used as a host for recombinant protein production, escherichia coli is unsuitable for massive screening of recombinant clones, owing to its poor secretion of proteins. a vector system containing t4 holin and t7 lysozyme genes under the control of the ptsg promoter derivative that is inducible in the absence of glucose was developed for programmed cell lysis of e. coli. because e. coli harboring the vector grows well in the presence of glucose, but is lysed upon glucose exhaustion ... | 2007 | 18051328 |
| the prevalence of iodine deficiency in women of reproductive age in the united states of america. | to review the iodine status of women as assessed through national health and nutrition examination surveys from 1971 to 2002.design and setting: national normative estimates of iodine status of the civilian, non-institutionalized population in the united states of america. | 2007 | 18053275 |
| evaluating iodine deficiency in pregnant women and young infants-complex physiology with a risk of misinterpretation. | to review methods for evaluating iodine deficiency in pregnant women and young infants and to discuss factors to be considered in the interpretation of their results. | 2007 | 18053278 |
| iodine deficiency and brain development in the first half of pregnancy. | an inadequate supply of iodine during gestation results in damage to the foetal brain that is irreversible by mid-gestation unless timely interventions can correct the accompanying maternal hypothyroxinemia. even mild to moderate maternal hypothyroxinemia may result in suboptimal neurodevelopment. this review mainly focuses on iodine and thyroid hormone economy up to mid-gestation, a period during which the mother is the only source for the developing brain of the foetus. the cerebral cortex of ... | 2007 | 18053280 |
| recombinant human thyroid stimulating hormone does not acutely change serum osteoprotegerin and soluble receptor activator of nuclear factor-kappabeta ligand in patients under evaluation for differentiated thyroid carcinoma. | some extra-thyroid actions of thyroid stimulating hormone (tsh), such as an in vitro action on bone, have been described. our aim was to evaluate in vivo the acute effect of a recombinant human tsh (rhtsh)-induced tsh surge on osteoprotegerin (opg) and receptor activator of the nuclear factor-kappabeta (rank-l) levels in patients under levo-thyroxine (l-t4) therapy. | 2007 | 18055421 |
| poor nutrient intakes during 1-year follow-up with community-dwelling older adults with early-stage alzheimer dementia compared to cognitively intact matched controls. | decreased food intakes, eating behavior disturbances, and loss of body weight are particularly significant problems among those with alzheimer dementia. to follow the natural evolution of dietary and nutrition status among elderly community-dwelling adults with alzheimer dementia. | 2007 | 18060894 |
| [cloning and analysis of the vibrio harveyi dam gene]. | the dna adenine methylase (dam) gene was cloned by degenerate pcr from vibrio harveyi strain t4. the gene was 840bp in length and encoded a putative protein of 279 amino acids that shared relatively high homology with the dam of other vibrios, especially with that of v. parahaemolyticus (96% in identity). the v. harveyi dam gene was subcloned into plasmid pbr322 and the resulting plasmid pbd was introduced into the e. coli strain er2925 in which the dam gene had been knocked out. dpn i, dpn ii, ... | 2007 | 18062262 |
| cardiovascular risk in elderly hypothyroid patients. | overt hypothyroidism (oh) and subclinical hypothyroidism (sh) are frequently found in the elderly. oh is associated with several functional cardiovascular abnormalities and increased risk of atherosclerosis resulting from hypertension associated to atherogenic lipid profile. other potential atherogenic factors involved in oh are increased circulating c-reactive protein and homocysteine, increased arterial stiffness, endothelial dysfunction, and altered coagulation parameters. similar (although m ... | 2007 | 18047429 |
| [traumatic lumbosacral fracture dislocation: a case report and review of the literature]. | lumbosacral dislocation is uncommon. we report a case of traumatic lumbosacral dislocation which occurred in a 33-year-old pedestrian traffic accident victim. the posterior impact produced lumbar injury with diffuse pain exacerbated at the lumbosacral junction. ecchymotic diffusion involving the entire lumbar region fluctuated due to the presence of a subcutaneous hematoma. the neurological examination revealed incomplete l5 paraplegia. standard x-rays revealed l5-s1 spondylolisthesis and fractu ... | 2007 | 18065885 |
| [therapeutic effects of transsphincteric surgery in treating rectal tumors: a report of 97 cases]. | to evaluate the role of transsphincteric surgery in local excision of mid and lower rectal tumors. | 2007 | 18067707 |
| [construction of a recombinant pim3-expressing plasmid and expression and activity thereof: experiment with rats]. | to construct a plasmid expressing green fluorescent protein (gfp) and gene of pim-3, a member of the serine/threonine kinase family, and to investigate the in vivo expression of the construct and its effect on cell apoptosis. | 2007 | 18067836 |
| stereochemical criteria for prediction of the effects of proline mutations on protein stability. | when incorporated into a polypeptide chain, proline (pro) differs from all other naturally occurring amino acid residues in two important respects. the phi dihedral angle of pro is constrained to values close to -65 degrees and pro lacks an amide hydrogen. consequently, mutations which result in introduction of pro can significantly affect protein stability. in the present work, we describe a procedure to accurately predict the effect of pro introduction on protein thermodynamic stability. seven ... | 2007 | 18069886 |
| [treatment effects of magnetic twin-block appliance for class ii cases]. | to evaluate the effects of magnetic twin-block appliance in the treatment of skeletal class ii cases. | 2007 | 18070424 |
| sleeve pneumonectomy for lung cancer--survival and complications (single-center experience with 42 patients). | sleeve pneumonectomy is challenging both from the technical and oncological standpoint. the benefit of induction treatment is still under investigation. | 2007 | 18074910 |