Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| influence of dietary fats on ecstasy-induced hyperthermia. | studies were designed to examine the effects of dietary fats on metabolic effects of 3,4-methylenedioxymethamphetamine (mdma, ecstasy). these effects included hyperthermia, expression of uncoupling protein (ucp1 and 3) in brown adipose tissue or skeletal muscle and plasma free fatty acid (ffa) levels. | 2007 | 17533413 |
| [description of the medical care of younger patients (<65 years) with colorectal cancer in schleswig-holstein--are diagnostics and therapy compliant with the actual s3-guidelines?]. | the guideline colorectal cancer has been existed since 1999. in 2004, a revision was published in form of the s3-guideline (number of the awmf registry: 021/007). in this study we aimed to evaluate whether diagnostics and therapy of colorectal cancer of younger patients (<65 years) in schleswig-holstein (sh) were in accordance with the guideline or not. therefore patients from a molecular genetic research project ("popgen") were asked to complete a questionnaire regarding their medical care. dat ... | 2007 | 17533563 |
| [long-term follow-up of oral language development in children with permanent bilateral hearing loss]. | the aim of this study was to assess the oral language development of children with permanent bilateral hearing loss without additional disabilities longitudinally (5 time points t1-t5). | 2007 | 17533568 |
| differential t4 degradation pathways in young patients with preterminal and terminal renal failure. | the aim of this study is to analyze thyroid hormone parameters in large homogenous patient cohorts with preterminal (stage 4) and terminal (stage 5) renal failure in an area of low iodine intake. | 2007 | 17533577 |
| thyroid hormone resistance without mutations in thyroid hormone receptor beta. | resistance to thyroid hormone (rth) is a rare autosomal dominant disorder that leads to elevated free thyroid hormone levels in the presence of normal or increased serum thyroid-stimulating hormone (tsh) concentrations if it is generalized because both the pituitary and peripheral tissues are then partially resistant. in approximately 85% of patients with rth, mutations in the thyroid hormone receptor beta (tr beta) gene can be identified. | 2007 | 17534237 |
| tsh concentration within the normal range is associated with cognitive function and adhd symptoms in healthy preschoolers. | thyroid hormone concentrations outside the normal range affect brain development, but their specific influence on behaviour and mental abilities within normal values is unknown. the objective of this study was to investigate whether thyroid hormone concentrations are related to neurodevelopment and adhd (attention deficit and hyperactivity disorder) symptoms in healthy preschoolers. design subjects and measurements: children from two general population birth cohorts in menorca (n = 289) and ribe ... | 2007 | 17535399 |
| melatonin and thyroxine response to pollution in white stork nestlings (ciconia ciconia): aspects of rhythmicity and age. | there is growing evidence that ubiquitous environmental contaminants may interfere with vertebrate endocrine systems. the selected endocrine biomarkers are used to indicate the condition of free-ranging populations of wildlife, including avian species. the aim of this study was to determine the impact of environment quality on serum thyroxine (t4) and melatonin (mel) in white stork nestlings (ciconia ciconia) living in different locations: small villages in natural areas surrounded by forests an ... | 2007 | 17535774 |
| cardiac angiotensin ii type i and type ii receptors are increased in rats submitted to experimental hypothyroidism. | this study assessed the behaviour of angiotensin ii (ang ii) receptors in an experimental hypothyroidism model in male wistar rats. animals were subjected to thyroidectomy and resting for 14 days. the alteration of cardiac mass was evaluated by total heart weight (hw), right ventricle weight (rvw), left ventricle weight (lvw), ratio of hw, rvw and lvw to body weight (bw) and atrial natriuretic factor (anf) expression. cardiac and plasma ang ii levels and serum t3 and t4 were determined. the mrna ... | 2007 | 17540701 |
| lymphoepithelioma-like carcinoma of the urinary tract: a clinicopathological study of 30 pure and mixed cases. | we studied 28 cases of lymphoepithelioma-like carcinoma of the bladder, one case in the renal pelvis, and one in the urethra. the mean age of the patients was 67.6 years with 21 (70%) males. seventeen cases (56.7%) were pure with the remaining mixed with other patterns of carcinoma, including invasive urothelial carcinoma (n=10), invasive adenocarcinoma (n=3), and squamous cell carcinoma (n=2). the surface demonstrated carcinoma in situ (cis) in six cases, noninvasive high-grade papillary urothe ... | 2007 | 17541442 |
| micropapillary bladder cancer: a review of the university of texas m. d. anderson cancer center experience with 100 consecutive patients. | micropapillary bladder carcinoma is a rare variant of urothelial carcinoma. to improve understanding of this disease, the authors performed a retrospective review of their experience. | 2007 | 17542024 |
| psoriasiform lesions and abscesses as initial manifestations of severe hypothyroidism in a previously healthy 15-year-old girl. | hypothyroidism is associated with many characteristic cutaneous manifestations; however, to the best of our knowledge, it has not previously been linked to psoriasiform lesions or multiple abscesses. we describe a previously healthy 15-year-old girl with psoriasiform lesions, abscesses, and extremely severe hypothyroidism, all presenting simultaneously. the pathophysiology of the connection is unclear, but several hypotheses are discussed. the temporal relationship of these conditions and the si ... | 2007 | 17542892 |
| thyroid hormones, learning and memory. | thyroid hormones (ths), t3 and t4, have many physiological actions and are essential for normal behavioral, intellectual and neurological development. ths have a broad spectrum of effects on the developing brain and mediate important effects within the cns throughout life. insufficient maternal iodine intake during gestation and th deficiency during human development are associated to pathological alterations such as cretinism and mental retardation. in adulthood, thyroid dysfunction is related ... | 2007 | 17543038 |
| assembly of the small outer capsid protein, soc, on bacteriophage t4: a novel system for high density display of multiple large anthrax toxins and foreign proteins on phage capsid. | bacteriophage t4 capsid is a prolate icosahedron composed of the major capsid protein gp23*, the vertex protein gp24*, and the portal protein gp20. assembled on its surface are 810 molecules of the non-essential small outer capsid protein, soc (10 kda), and 155 molecules of the highly antigenic outer capsid protein, hoc (39 kda). in this study soc, a "triplex" protein that stabilizes t4 capsid, is targeted for molecular engineering of t4 particle surface. using a defined in vitro assembly system ... | 2007 | 17544446 |
| plasma leptin levels are related to body composition, sex, insulin levels and the a55v polymorphism of the ucp2 gene. | circulating leptin levels show a high degree of individual variability even after the main effect of body fatness is accounted for. we therefore wanted to determine the roles of variation in body composition, age, sex and polymorphisms of the ucp2 gene and promoter region on levels of circulating leptin. | 2007 | 17342078 |
| an evidence-based review of poorly differentiated thyroid cancer. | poorly differentiated thyroid cancer (pdtc) presents the endocrinologist and surgeon with challenges of recognition and treatment given the lack of consensus on histopathologic definition and limited literature on surgical and nonsurgical treatment. | 2007 | 17431717 |
| the role of surgery in the treatment of stage iii non-small-cell lung cancer. | stage iii, locally advanced non-small-cell lung cancer represents an incredibly heterogeneous group of patients. the majority of patients are treated with curative intent, but optimal therapy is controversial and the role of surgery is not well defined. consensus has shown that the majority of patients with iiib disease are not amenable to resection. the exceptions are selected patients with tumor stage 4 (t4) by virtue of a satellite nodule or those with isolated invasion of the spine, superior ... | 2007 | 17588348 |
| serum free t4 and thyroid stimulating hormone levels in preterm infants and relationship between these levels and respiratory distress syndrome. | there have been few studies of the thyroid stimulating hormone (tsh) surge in extremely low-birthweight (elbw) infants, and the relationship between thyroid hormones and respiratory distress syndrome (rds) has yet to be clarified. the present study sought to determine the serum levels of free t4 (ft4) and tsh in elbw infants and to examine the relationship between these levels and the development of rds. | 2007 | 17587266 |
| bronchoalveolar lavage quality influences the t4/t8 ratio in sarcoidosis. | sarcoidosis is characterised by a t-lymphocytic alveolitis with a typically increased t4/t8 ratio. the diagnostic value of this ratio is under debate. | 2007 | 17587560 |
| awake anaesthesia for major thoracic surgical procedures: an observational study. | major thoracic surgical procedures are rarely performed under awake anaesthesia. the purpose of this study is to review the experience of a tertiary center in major thoracic surgical procedures done under awake anaesthesia. | 2007 | 17580117 |
| establishment of reference intervals for thyroid- stimulating hormone and free thyroxine in amniotic fluid using the bayer advia centaur. | thyroid hormone concentrations in amniotic fluid (af) can aid in the diagnosis of fetal hypothyroidism. however, the availability of reference intervals for thyroid hormones in af using current methods is limited. the purpose of this study was to validate the bayer advia centaur (bayer healthcare, tarrytown, ny) third-generation thyroid-stimulating hormone (tsh), total thyroxine (t4), and free thyroxine (ft4) assays for use with af and establish reference intervals for these thyroid hormones in ... | 2007 | 17580284 |
| not all g-quadruplexes exhibit ion-channel-like properties: nmr study of ammonium ion (non)movement within the d(g(3)t(4)g(4))(2) quadruplex. | a solution-state nmr study on 15nh4(+) ion movement within d(g(3)t(4)g(4))(2), a dimeric g-quadruplex consisting of three g-quartets and two t(4) loops, rather unexpectedly demonstrated the absence of 15nh4(+) ion movement between the binding sites u and l along the central axis of the g-quadruplex. distinct temperature dependences of autocorrelation signals for u and l binding sites have been observed in 15n-1h nzexhsqc spectra which correlate with the local stiffness of the g-quadruplex. the v ... | 2007 | 17580943 |
| blood coagulation activation and fibrinolysis during a downhill marathon run. | prolonged physical exercise is associated with multiple changes in blood hemostasis. eccentric muscle activation induces microtrauma of skeletal muscles, inducing an inflammatory response. since there is a link between inflammation and coagulation we speculated that downhill running strongly activates the coagulation system. thirteen volunteers participated in the tyrolean speed marathon (42,195 m downhill race, 795 m vertical distance). venous blood was collected 3 days (t1) and 3 h (t2) before ... | 2007 | 17581317 |
| validation of a new arterial pulse contour-based cardiac output device. | to evaluate the accuracy and precision of an arterial pulse contour-based continuous cardiac output device (vigileo). vigileo cardiac output (vigileoco) was compared with intermittent transpulmonary thermodilution cardiac output (tpco) and an established arterial pulse contour-based cardiac output (pcco). | 2007 | 17581493 |
| a new 10-min ligation method using a modified buffer system with a very low amount of t4 dna ligase: the "coffee break ligation" technique. | the ligation reaction is widely used in molecular biology. there are several kits available that complete the ligation reaction very rapidly but they are rather expensive. in this study, we successfully modified the ligation buffer with much lower cost than existing kits. the ligation reaction can be completed in 10 min using very low activities such as 0.01 u t4 dna ligase, and costs only $1 for 100 reactions of 20 microl scale. we name this ligation system the "coffee break ligation" system; o ... | 2007 | 17581703 |
| unequal concentrations of free t3 and free t4 after ultrafiltration. | 2007 | 17582152 | |
| methylmercury inhibition of type ii 5'-deiodinase activity resulting in a decrease in growth hormone production in gh3 cells. | we have recently reported that methylmercury (mehg) inhibits type ii iodothyronine 5'-deiodinase (d2) activity in mouse neuroblastoma nb41a3 cells. in the present study, we determined the biological significance of d2 inhibition by mehg. gh3 rat pituitary tumor cells were treated with mehg and d2 activity and production of a thyroid hormone-responsive gene product, growth hormone (gh) were analyzed. mehg inhibited d2 activity and decreased thyroxine (t4)-induced, but not 3,3',5-triiodothyronine ... | 2007 | 17582671 |
| the effects of treatment of subclinical hypothyroidism on metabolic control and hyperinsulinemia. | we examined the effects of treatment of subclinical hypothyroidism (sh) on metabolic control and hyperinsulinemia. the study included 53 patients ages 53.42+/-3.11 years, bmi = 28.43+/-1.67 kg/m2, with sh. laboratory evaluation included serum free t3, free t4, tsh, thyroid antibodies, tgl, insulin, c-peptide and glucose during ogtt, hba1c, crp and level of lipids. twelve sh patients (37.7 %) had diabetes mellitus (dm), 14 patients (26.4 %) had glucose intolerance (gi) and 35 patients were obese ... | 2007 | 17582969 |
| the icd shock and stress management program: a randomized trial of psychosocial treatment to optimize quality of life in icd patients. | implantable cardioverter defibrillator (icd) patients potentially face significant psychological distress because of their risk for life-threatening arrhythmias and the occurrence of icd shock. | 2007 | 17584267 |
| comparative effectiveness of methylprednisolone and zero-balance ultrafiltration on inflammatory response after pediatric cardiopulmonary bypass. | studies have demonstrated that systemic inflammatory response syndrome (sirs) remains one of the major causes of cardiopulmonary bypass (cpb)-associated organ injury during pediatric cardiac surgery. the purpose of this investigation was to compare the effectiveness of methylprednisolone (mp) and zero-balance ultrafiltration (zbuf) on sirs during pediatric cpb. thirty infants undergoing open-heart surgeries were randomized to receive either mp in the priming solution (group m, n = 15) or zbuf du ... | 2007 | 17584482 |
| accelerated radiotherapy and larynx preservation in favorable-risk patients with t2 or worse hypopharyngeal cancer. | to evaluate the advantage of accelerated fractionation radiotherapy for patients with hypopharyngeal cancer requiring total laryngectomy. | 2007 | 17584824 |
| the c-terminal domain of t4 rna ligase 1 confers specificity for trna repair. | t4 rna ligase 1 (rnl1) is a trna repair enzyme that thwarts a trna-damaging host response to virus infection. the 374-aa rnl1 protein consists of an n-terminal nucleotidyltransferase domain fused to a unique c-terminal domain composed of 10 alpha helices. we exploited an in vitro trna splicing system to demonstrate that rnl1 has an inherent specificity for sealing trna with a break in the anticodon loop. the trna specificity is imparted by the c domain, any deletion of which caused the broken tr ... | 2007 | 17585047 |
| thoracic pedicle screw placement: analysis using anatomical landmarks without image guidance. | prospective laboratory study analyzing the technique of pedicle screw placement in a cadaveric model. | 2007 | 17585271 |
| trajectories and predictors of indirect aggression: results from a nationally representative longitudinal study of canadian children aged 2-10. | the purposes of this study were to model the development of indirect aggression among a nationally representative sample of 1,401 canadian children aged 4 at t2, 6 at t3, 8 at t4 and 10 at t5, and to examine predictors of trajectory group membership from t1 (age 2) child, familial, and parenting variables. using a semi-parametric group-based modeling approach, two distinct trajectories were identified: "increasing users" comprising of 35% of the sample and "stable low users" comprising of 65% of ... | 2007 | 17593562 |
| dioxin-like and transthyretin-binding compounds in indoor dusts collected from japan: average daily dose and possible implications for children. | many researchers are increasingly interested in human exposure to house dust containing household compounds such as polybrominated diphenylethers (pbdes). nevertheless, no investigations have addressed the endocrine-disrupting potencies of compounds contained in indoor dust. this study specifically addresses endocrine-disrupting potencies such as dioxin-like activity and human transthyretin (ttr)-binding potencies. using in vitro bioassays, we investigated these activity levels in indoor dusts. ... | 2007 | 17593761 |
| temperature-dependent kinetics study of the gas-phase reactions of oh with n- and i-propyl bromide. | an experimental, temperature-dependent kinetics study of the gas-phase reactions of hydroxyl radical with n-propyl bromide, oh+n-c3h7br-->products (reaction 1), and i-propyl bromide, oh+i-c3h7br-->products (reaction 2), has been performed over wide ranges of temperatures 297-725 and 297-715 k, respectively, and at pressures between 6.67 and 26.76 kpa by a pulsed laser photolysis/pulsed laser-induced fluorescence technique. data sets of absolute bimolecular rate coefficients obtained in this stud ... | 2007 | 17595069 |
| expression of p21(wafl/cip1), p57(kip2) and her2/neu in patients with gallbladder cancer. | to improve the prognosis of gallbladder cancer (gc) patients, a better understanding of the mechanisms of tumor development and progression is essential. the deregulation of cell cycle control is a critical step in the development of cancer. the purpose of this study was to investigate the expression of p21(wafl/cip1), p57(kip2) and her2/neu in an unselected gc patient population and to assess the association of these markers with p27(kip1) expression, p53 gene mutation status and clinical param ... | 2007 | 17595796 |
| clinical and endocrine features and long-term outcome of graves' disease in early childhood. | hyperthyroidism is rare in early childhood and most commonly caused by graves' disease. we report 14 children (4 boys, 10 girls) aged 3.4-7.5 yr. at diagnosis, all patients had weight loss, hyperkinetic activity, tachycardia, difficulty sleeping, and poor concentration and 11 presented with proptosis. four patients developed long-term neuropsychological problems. there was a family history in 7 cases. all patients had goiters, clinically assessed to be large and diffuse in 21%, medium-sized in 4 ... | 2007 | 17598970 |
| predicting absolute ligand binding free energies to a simple model site. | a central challenge in structure-based ligand design is the accurate prediction of binding free energies. here we apply alchemical free energy calculations in explicit solvent to predict ligand binding in a model cavity in t4 lysozyme. even in this simple site, there are challenges. we made systematic improvements, beginning with single poses from docking, then including multiple poses, additional protein conformational changes, and using an improved charge model. computed absolute binding free ... | 2007 | 17599350 |
| improved results of induction chemoradiation before surgical intervention for selected patients with stage iiia-n2 non-small cell lung cancer. | optimal management of stage iiia-n2 non-small cell lung cancer remains controversial. the surgical arm of the north american intergroup 0139 trial was adopted as the standard treatment for patients with resectable n2 disease at the university health network. results after 7 years of experience are reported. | 2007 | 17599507 |
| matrix metalloproteinase-1 (-1607) 1g/2g and -9 (-1562) c/t promoter polymorphisms: susceptibility and prognostic implications in nasopharyngeal carcinomas. | matrix metalloproteinases (mmps) are proteolytic enzymes that play important roles in tumor invasion and metastasis by degrading extracellular matrix components. genetic variations in promoter regions of mmp genes, affecting their expression, have been associated with susceptibility to cancers. the aim of this study was to investigate the susceptibility and prognostic implications of the mmp-1 (-1607) 1g/2g and mmp-9 (-1562) c/t polymorphisms in nasopharyngeal carcinomas. | 2007 | 17599818 |
| short versus conventional preoperative radiotherapy of rectal cancer: indications. | preoperative radiotherapy (rt) at high-dose short-course or at conventional fractions for rectal cancer has proven effect in increasing the tumor control. the aim of this study was to test the impact of 2 different preoperative rt schemes on local recurrence, distant metastasis and survival rates and to defi ne the indications for each of them. | 2007 | 17600877 |
| a mathematical model of pituitary--thyroid interaction to provide an insight into the nature of the thyrotropin--thyroid hormone relationship. | the mathematical model proposed focuses on the description of the behavior of the interaction between thyrotropin (i.e. thyroid-stimulating hormone (tsh)) and thyroid hormones with the objective of providing a better understanding of the behavior of tsh-t4 relationship in health and in disease. the normal pituitary-thyroid axis is tightly coupled and regulated with a servomechanism. in the physiological situation, any elevation of thyroid hormones will inhibit tsh secretion by the thyrotrophs of ... | 2007 | 17602707 |
| the neck of bacteriophage t4 is a ring-like structure formed by a hetero-oligomer of gp13 and gp14. | after packaging of dna into the head of bacteriophage t4 is completed, a neck is formed at the portal vertex of the head to be ready for the tail attachment. the main components of the neck are gp13 and gp14 (gp: gene product), which consist of 309 and 256 amino acid residues, respectively. in order to elucidate the structure and subunit arrangement in the neck, overexpression systems of gene 13 and gene 14 were constructed and purified to homogeneity. far-uv circular dichroism (cd) spectra of g ... | 2007 | 17602902 |
| t4 breast cancer under closer inspection: a case for revision of the tnm classification. | the presence of skin involvement in breast cancer results in the classification of the tumor into the highest tumor category, and accordingly into the highest non-metastatic disease stage (current tnm classification: t4/stage iii). this traditional view is no longer justifiable, as tumors that show non-inflammatory skin involvement (t4b) make up a considerably heterogeneous group with a high percentage of small-sized tumors. classifying all lesions demonstrating this feature together results in ... | 2007 | 17604172 |
| concurrent chemoradiotherapy for t4 patients with hypopharyngeal and laryngeal squamous cell carcinomas. | concurrent chemoradiotherapy (ccr) was given for the previously untreated t4 hypopharyngeal and laryngeal squamous cell carcinoma patients and the response and survival rates were evaluated. | 2007 | 17604583 |
| assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (pfoa) concentrations in fluorochemical production workers. | perfluorooctanoic acid (pfoa) results in peroxisome proliferator mediated effects in rats and mice resulting in hypolipidemia but not in monkeys. counterintuitive modestly positive associations between pfoa and cholesterol levels in production workers have been inconsistently reported. the purpose of this assessment was to examine this association in male workers who manufactured or used pfoa at three facilities. | 2007 | 17605032 |
| the iaslc lung cancer staging project: proposals for the revision of the t descriptors in the forthcoming (seventh) edition of the tnm classification for lung cancer. | to propose changes in the seventh revision of the tumor, node, metastasis (tnm) classification for lung cancer. | 2007 | 17607114 |
| salvage surgery with free flap reconstruction: factors affecting outcome after treatment of recurrent head and neck squamous carcinoma. | to determine factors predicting the outcome after salvage surgery with microvascular flap reconstruction for recurrent squamous cell cancer (scc) of the head and neck. | 2007 | 17545864 |
| [evidences for subclinic chronic autoimmune thyroid disease in girls with turner syndrome]. | patients with turner syndrome (ts) frequently exhibit transient, recurrent and asymptomatic variations of tsh and/or thyroid hormones (th). this work was carried out to evaluate thyroid function and structure in patients with ts who had had such variations in hormone concentrations. our sample comprised 24 patients, 17 less than 20-years old. evaluation included serum levels of tsh, free t4, total t3, tpo and tg autoantibodies, thyroid ultrasound (us) and scintigraphy with 99mtc-pertechnetate. t ... | 2007 | 17546238 |
| transoral laser microsurgery for carcinoma of the supraglottic larynx. | the study goal was to report the oncologic outcomes of transoral laser microsurgery (tlm) in the treatment of squamous cell carcinoma of the supraglottic larynx. | 2007 | 17547977 |
| combined therapy after superselective arterial cisplatin infusion to treat maxillary squamous cell carcinoma. | we sought to assess the efficacy of combined therapy after superselective arterial cisplatin infusion (saci) therapy to treat the maxillary squamous cell carcinoma. | 2007 | 17547996 |
| evaluation of nad(+) -dependent dna ligase of mycobacteria as a potential target for antibiotics. | mycobacteria contain genes for several dna ligases, including liga, which encodes a nad(+)-dependent enzyme that has been postulated to be a target for novel antibacterial compounds. using a homologous recombination system, direct evidence is presented that wild-type liga cannot be deleted from the chromosome of mycobacterium smegmatis. deletions of native liga in m. smegmatis could be obtained only after the integration of an extra copy of m. smegmatis or mycobacterium tuberculosis liga into th ... | 2007 | 17548501 |
| administration of additional inactive iodide during radioiodine therapy for graves' disease: who might benefit? | graves' hyperthyroidism and antithyroid drugs empty the intrathyroid stores of hormones and iodine. the consequence is rapid 131i turnover and impending failure of radioiodine therapy. can administration of additional inactive iodide improve 131i kinetics? | 2007 | 17549318 |
| the role of the endothelin axis and microvessel density in bladder cancer - correlation with tumor angiogenesis and clinical prognosis. | endothelin-1 (et-1) and its receptors, entothelin-a (etar) and endothelin-b (etbr), commonly referred to as the endothelin (et)-axis, are involved in tumor biology and growth. we investigated the effects of the et-axis on microvessel density (mvd) and the clinicopathological parameters of patients with invasive bladder cancer. paraffin tumor sections of 120 patients who had undergone radical cystectomy were assessed immunohistochemically using mono- and polyclonal antibodies for et-1, etar, etbr ... | 2007 | 17549358 |
| surgical management and outcome in primary adenocarcinoma of the small bowel. | primary adenocarcinoma of the small bowel is a rare malignancy and is associated with poor survival outcome. patient, tumor and treatment-related factors were analyzed for their association with recurrence and survival. | 2007 | 17549572 |
| phase ii study of preoperative irradiation and chemotherapy with capecitabine in patients with locally advanced rectal carcinoma. | preoperative chemoradiotherapy has demonstrated to improve resectability and local control in locally advanced rectal cancer (larc). 5-fluorouracil (5fu) has traditionally been the drug of choice in combination with radiation therapy. early studies of capecitabine (cap) have shown its potential to replace 5fu. between march 2002 and april 2005, 31 patients with newly diagnosed larc (t2 n+ 2 cases, t3 n0-n+ 25 cases, t4 n0-n+ 4 cases) received the combined treatment. surgery was planned 6-8 weeks ... | 2007 | 17550133 |
| is final tnm staging a predictor for survival in locally advanced rectal cancer after preoperative chemoradiation therapy? | neoadjuvant chemoradiation therapy has improved the local control rate and overall survival in locally advanced rectal cancers. the purpose of this retrospective study is to evaluate the correlation between the final pathologic stage and survival in these patients. | 2007 | 17551794 |
| [the assessment of body composition using dexa in patients with thyroid dysfunction]. | disturbed thyroid function is accompanied with weight changes in most of patients. less is known how the therapy of hyperthyroidism and hypothyroidism influences their body composition. | 2007 | 17554975 |
| [effects of iodine excess and selenium supplement on the levels of thyroid hormone and its receptor expression in filial cerebrum of mice]. | to study effects of iodine excess on the levels of serum t4 and t3 and tralpha1 and trbeta1 expression in the cerebrum of filial mice and the supplement of selenium. | 2007 | 17555094 |
| the association of time of day and serum testosterone concentration in a large screening population. | to assess testosterone patterns during clinical hours in a large population of men participating in a national screening programme for prostate cancer, as the effect of time of day on serum testosterone concentration is unclear and largely reported in small studies. | 2007 | 17555474 |
| clinical relevance of highly sensitive tg assay in monitoring patients treated for differentiated thyroid cancer. | serum thyroglobulin (tg) represents a highly specific biomarker for detecting residual thyroid tissue/recurrence/metastases after treatment for differentiated thyroid cancer (dtc). we evaluated the clinical impact of a highly sensitive tg assay during routine follow-up of dtc patients. | 2007 | 17555505 |
| neurosensory and functional impairment in sagittal split osteotomies: a longitudinal and long-term follow-up study. | the aim was to conduct a long-term follow-up study on the function and sensitivity of the mandible in advancement and setback patients after bilateral sagittal split osteotomy (bsso) with rigid internal fixation. the advancement and setback groups consisted of 16 (12 females and 4 males, mean age: 21.4 and 21.3 years, respectively) and 17 (11 females and 6 males, mean age: 27.1 and 27.7 years, respectively). the final follow-up was a mean of 12.7 years (t4) post-operatively. the other follow-up ... | 2007 | 17556728 |
| proposal of a diagnostic test for the detection of preterm premature rupture of membranes based on the determination of thyroid hormones in vaginal washing fluid. | to determine whether measurement of total t3 (triiodothyronine) , total t4 (thyroxine), free t3 (free triiodothyronine) and free t4 (free thyroxine) levels in vaginal fluid is useful for the diagnosis of preterm premature rupture of membranes (pprom). | 2007 | 17556818 |
| ultrasonography thyroid volume estimation in hyperthyroid patients treated with individual radioiodine dose. | radioiodine (rai) therapy is a safe and effective treatment for hyperthyroidism and individual doses are frequently administered. initial thyroid volume (tv) is an important parameter for rai therapy. ultrasonography (us) is considered the most reliable method of determining tv. the aim of this study was to evaluate tv by means of us in a cohort of 75 hyperthyroid patients before and after rai therapy. according to clinical examination, thyroid us and technetium-99m (99mtc)-pernechnetate scintis ... | 2007 | 17556869 |
| viral dna packaging studied by fluorescence correlation spectroscopy. | the dna packaging machinery of bacteriophage t4 was studied in vitro using fluorescence correlation spectroscopy. the atp-dependent translocation kinetics of labeled dna from the bulk solution, to the phage interior, was measured by monitoring the accompanied decrease in dna diffusibility. it was found that multiple short dna fragments (100 basepairs) can be sequentially packaged by an individual phage prohead. fluorescence resonance energy transfer between green fluorescent protein donors withi ... | 2007 | 17557791 |
| microsatellite instability in poorly differentiated adenocarcinomas of the colon and rectum: relationship to clinicopathological features. | poorly differentiated adenocarcinomas of the colon and rectum (por) feature the worst prognosis among the various types of colorectal carcinomas. por is highly associated with microsatellite instability (msi), although msi is associated with an improved prognosis in colorectal cancers. | 2007 | 17557871 |
| preoperative undetectable serum thyroglobulin in differentiated thyroid carcinoma: incidence, causes and management strategy. | in recent years serum thyroglobulin (tg) measurement during thyroxine (t4) treatment and/or after stimulation by endogenous tsh or recombinant human tsh (rhtsh) has eclipsed other diagnostic procedures in managing patients with differentiated thyroid cancer (dtc). however, preoperative undetectable tg was reported in up to 12% of patients affected by dtc and recurrences of dtc with no increase in serum tg have also been described. clearly, a negative tg measurement may falsely reassure both the ... | 2007 | 17561976 |
| [cloning and identification of microrna from human osteosarcoma cell line sosp-9607]. | microrna (mirna), a group of non-coding small rna (20-25 nt) involved in post-transcriptional regulation, regulate gene expression and closely relate to cancer pathogenesis. this study was to clone mirna from osteosarcoma cell line sosp-9607, and identify the expression of some functional genes. | 2007 | 17562257 |
| the impact of health insurance status on stage at diagnosis of oropharyngeal cancer. | although patients who have early-stage oropharyngeal cancer can be treated with little impairment of function, the treatment of advanced disease can result in decreased quality of life and mortality. patients without insurance and with other barriers to access to care may delay seeking medical attention for early symptoms, resulting in more advanced disease at presentation. in this study, the authors examined whether patients who had no insurance or who were covered by medicaid insurance were mo ... | 2007 | 17562558 |
| [clinical study of adenoid cystic carcinoma of the parotid gland]. | we report results of a retrospective study of 12 cases of adenoid cystic carcinoma (acc) in the parotid gland. local pain was often observed in acc among other malignant parotid tumors. although fine-needle aspiration cytology (fna) was not effective for preoperative diagnosis, frozen section diagnosis (fs) during surgery showed excellent results. cases with t3 or t4 underwent total or enlarged parotidectomy, but, often showed positive surgical margins. postoperative radiation therapy seemed use ... | 2007 | 17564131 |
| the usefulness of transesophageal echocardiography in the staging of locally advanced lung cancer. | the pre-operative staging of locally advanced non-small cell lung cancer (nsclc) is an important clinical and radiological issue. computed tomography (ct) scan cannot always provide sufficient information about resectability and some patients may undergo unnecessary thoracotomy. the purpose of this study was to evaluate the utility of transesophageal echocardiography (tee) in distinguishing t3 from t4 lesions in patients with lung cancer possibly involving cardiovascular structures and to compar ... | 2007 | 17564283 |
| genomic and structural analysis of syn9, a cyanophage infecting marine prochlorococcus and synechococcus. | cyanobacteriophage syn9 is a large, contractile-tailed bacteriophage infecting the widespread, numerically dominant marine cyanobacteria of the genera prochlorococcus and synechococcus. its 177,300 bp genome sequence encodes 226 putative proteins and six trnas. experimental and computational analyses identified genes likely involved in virion formation, nucleotide synthesis, and dna replication and repair. syn9 shows significant mosaicism when compared with related cyanophages s-pm2, p-ssm2 and ... | 2007 | 17564603 |
| sevoflurane increases fade of neuromuscular response to tof stimulation following rocuronium administration in children. a pk/pd analysis. | sevoflurane enhances neuromuscular block produced by rocuronium, affecting not only single twitch response but also the response to high-frequency stimulation, increasing tetanic [or train-of-four (tof)] fade. | 2007 | 17564645 |
| [surgical strategy for stage iii non-small cell lung cancer; a review based on our experience and the literature]. | we reviewed our experience and the literature to clarify the resection indication and pre-/postoperative treatment for stage iii non-small cell lung cancer. surgery alone should not be applied to patients with stage iiia non-small cell lung cancer except for clinical t3n1m0 cases. an indication of pulmonary resection for clinical t1-3n2m0 cases should be added to preoperative induction therapy, such as chemo-or chemoradiation therapy. postoperative n2 cases, which were diagnosed as n0-1 disease ... | 2007 | 17565243 |
| evaluation of plantar hyperhidrosis in patients undergoing video-assisted thoracoscopic sympathectomy. | sympathectomy is the treatment of choice for primary hyperhidrosis. one curious occurrence that is difficult to explain from an anatomophysiological point of view in cases of video-assisted thoracoscopic sympathectomy (vats) for the treatment of palmar hyperhidrosis (ph) is the observed improvement in plantar hyperhidrosis (plh). nevertheless, current reports on vats rarely describe the effect on plh or just give superficial data. the aim of this study was to prospectively investigate, how surge ... | 2007 | 17565429 |
| activation of glycogen synthase kinase 3beta promotes the intermolecular association of tau. the use of fluorescence resonance energy transfer microscopy. | tau is hyperphosphorylated and undergoes proteolysis in alzheimer disease brain. caspase-cleaved tau efficiently forms fibrillary structures in vitro and in situ. glycogen synthase kinase 3beta (gsk3beta) phosphorylates tau and induces the aggregation of caspase-cleaved tau in situ. given the hypothesis that increased association of tau precedes the formation of fibrillar structures, we generated a cell model to quantitate the extent of tau association in situ using fluorescence resonance energy ... | 2007 | 17565981 |
| the feasibility of using delta15n and delta13c values for discriminating between conventionally and organically fertilized pepper (capsicum annuum l.). | a greenhouse experiment was conducted to determine the feasibility of using leaf and fruit delta15n and delta13c values to discriminate between conventionally and organically fertilized peppers, when conventional management involves the application of organic amendment for soil preparation. all of the treatments involved adding horse manure to the soil before applying different rates of synthetic n fertilizers: 0 (t1 and t2), 150 (t3), and 300 kg ha(-1) (t4). the difference between t1 and t2 was ... | 2007 | 17567025 |
| extending low-dose epidural analgesia in labour for emergency caesarean section - a comparison of levobupivacaine with or without fentanyl. | women in labour receiving epidural analgesia with 15 ml bupivacaine 0.1% and 2 microg.ml(-1) fentanyl followed by 10-15-ml top-ups as required, who needed caesarean section, were randomly allocated to receive 20 ml levobupivacaine 0.5% over 3 min with either 75 microg fentanyl (1.5 ml) or 1.5 ml saline. further top-ups or inhaled or intravenous supplementation were given for breakthrough pain. time to onset (loss of cold sensation to t4 and touch sensation to t5 bilaterally), quality of analgesi ... | 2007 | 17567341 |
| thyroid hormone replacement normalizes renal renin and angiotensin receptor expression in thyroidectomized fetal sheep. | previous studies have suggested that thyroid hormone influences maturation of the renin-angiotensin system (ras) and cardiovascular function in the late-gestation fetal sheep. to further examine the importance of thyroid hormone in this regard, we used the technique of thyroidectomy (tx) to remove endogenous thyroid hormone from the circulation and then replaced it with physiological amounts of exogenous thyroxine. we hypothesized that the previously observed changes in ras activity and cardiova ... | 2007 | 17567715 |
| effects of acute and subchronic exposures to waterborne selenite on the physiological stress response and oxidative stress indicators in juvenile rainbow trout. | selenium (se) is an essential element that may bioaccumulate to toxic levels. in fish, the major toxicity symptom is larval teratogenic deformities, but little is known about the effect of se on other systems such as the physiological stress response and oxidative stress. to test the hypothesis that se is a chemical stressor that causes toxicity through oxidative stress, juvenile rainbow trout were exposed to waterborne sodium selenite, and physiological stress response and stress-related parame ... | 2007 | 17568697 |
| expression and prognostic value of mg7-ag in patients with surgically resectable esophageal squamous cell carcinoma. | mg7-ag is a human gastric-carcinoma-associated antigen. the expression of mg7-ag was found to increase gradually with the development and progression of gastric cancer. moreover, a poorer prognosis was found in mg7-ag positive gastric-carcinoma patients than in mg7-ag negative patients. however, neither mg7-ag expression nor its clinical significance has been previously examined in squamous cell carcinoma (scc) of the esophagus. in this study, we examined the expression of mg7-ag in esophageal s ... | 2007 | 17570016 |
| thyroid hormone transporters in health and disease: advances in thyroid hormone deiodination. | thyroid hormone metabolism by the three deiodinase selenoproteins -- dio1, dio2, and dio3 -- regulates the local availability of various iodothyronine metabolites and thus mediates their effects on gene expression, thermoregulation, energy metabolism, and many key reactions during the development and maintenance of an adult organism. circulating serum levels of thyroid hormone and thyroid-stimulating hormone, used as a combined indicator of thyroid hormone status, reflect a composite picture of: ... | 2007 | 17574002 |
| tissue uptake of thyroid hormone by amino acid transporters. | thyroid hormones (ths) -- thyroxine (t4) and tri-iodothyronine (t3) -- are iodinated derivatives of the amino acid tyrosine, which regulates growth, development and critical metabolic functions. ths are taken up by target cells and act at the genomic level via nuclear thyroid receptors. saturable transport mechanisms mediate the greater part of th movement across the plasma membrane. system l1 permease is a transporter of ths and amino acids in mammalian adipose tissue, placenta and brain. t(3) ... | 2007 | 17574006 |
| an investigation into the prognostic significance of necrosis and hypoxia in high grade and invasive bladder cancer. | we investigated hypoxia and necrosis in high grade and invasive bladder cancer, and related this to prognosis. | 2007 | 17574616 |
| lymph node involvement in gastric cancer for different tumor sites and t stage: italian research group for gastric cancer (irggc) experience. | the aim of lymphadenectomy is to clear all the metastatic nodes achieving a complete removal of the tumor; nevertheless, its role in gastric cancer has been very much debated. | 2007 | 17576611 |
| intramolecular dna quadruplexes with different arrangements of short and long loops. | we have examined the folding, stability and kinetics of intramolecular quadruplexes formed by dna sequences containing four g3 tracts separated by either single t or t4 loops. all these sequences fold to form intramolecular quadruplexes and 1d-nmr spectra suggest that they each adopt unique structures (with the exception of the sequence with all three loops containing t4, which is polymorphic). the stability increases with the number of single t loops, though the arrangement of different length ... | 2007 | 17576685 |
| troponin t isoform expression is modulated during atlantic halibut metamorphosis. | flatfish metamorphosis is a thyroid hormone (th) driven process which leads to a dramatic change from a symmetrical larva to an asymmetrical juvenile. the effect of ths on muscle and in particular muscle sarcomer protein genes is largely unexplored in fish. the change in troponin t (tnt), a pivotal protein in the assembly of skeletal muscles sarcomeres and a modulator of calcium driven muscle contraction, during flatfish metamophosis is studied. | 2007 | 17577411 |
| [tumours of the large bowel and rectum: possibilities and limitations of sonographic evaluation]. | sonographic detection rate of colorectal tumours in comparison with endoscopy. | 2007 | 17577859 |
| correlation of her-2/neu protein overexpression with other prognostic and predictive factors in invasive ductal breast cancer. | the objective of our study was to investigate the association between her-2/neu status and other clinicopathological characteristics of ductal breast carcinoma. | 2007 | 17708365 |
| in vitro evaluation of the disinfection efficacy on eimeria tenella unsporulated oocysts isolated from broilers. | the objective of this study was to evaluate in vitro the action of eight chemical principles by disinfection efficacy (de) of eimeria tenella oocysts. disinfection efficacy was evaluated by either destruction or sporulation inhibition of the oocysts. eight treatments were performed: t1 (glutaraldehyde 42.5 g + benzalkonium chloride 7.5 g); t2 (benzalkonium chloride + quaternary ammonium salt); t3 (formol 37% + sodium dodecylbenzene sulfonate 12%); t4 (sodium hypochlorite 2%); t5 (orthodichlorobe ... | 2007 | 17706006 |
| [construction of bicistronic lentiviral vectors carrying hsv-tk and egfp gene]. | to construct cmv-mediated lentiviral vectors coexpressing egfp and hsv-tk gene in order to establish a novel lentiviral vector platform for the suicide gene therapy of eye disease. | 2007 | 17706084 |
| in vivo stabilization of mutant human transthyretin in transgenic mice. | transthyretin (ttr) is a 55 kd homotetrameric serum protein transporter of retinol binding protein charged with retinol and thyroxine (t4). the highly amyloidogenic human ttr variant in which leucine at position 55 is replaced by proline (l55p ttr) is responsible for aggressive fatal amyloidosis with peripheral and autonomic neuropathy, cardiomyopathy and nephropathy. mice bearing one or two copies of a 19.2 kb human genomic fragment containing the entire coding sequence and the known control re ... | 2007 | 17701470 |
| can thyroid dysfunction explicate severe menopausal symptoms? | many of the menopausal manifestations look like those accredited to thyroid hyperfunction or hypofunction. can thyroid dysfunction explicate severe menopausal symptoms? the study comprised 350 women with different menopausal symptoms. all women had serum tsh, t3 and free t4 estimated. women with thyroid dysfunction were appropriately treated and other women were treated with ert. the study showed that 21 women (6%) had hypothyroidism and 18 (5.1%) had hyperthyroidism. marked improvement in the m ... | 2007 | 17701801 |
| urinary tract infection in term neonates with prolonged jaundice. | the aim of this study was to evaluate the frequency of urinary tract infection (uti) in neonates with prolonged jaundice. | 2007 | 17701928 |
| dna polymerase proofreading: active site switching catalyzed by the bacteriophage t4 dna polymerase. | dna polymerases achieve high-fidelity dna replication in part by checking the accuracy of each nucleotide that is incorporated and, if a mistake is made, the incorrect nucleotide is removed before further primer extension takes place. in order to proofread, the primer-end must be separated from the template strand and transferred from the polymerase to the exonuclease active center where the excision reaction takes place; then the trimmed primer-end is returned to the polymerase active center. t ... | 2007 | 17702757 |
| the influence of endoscopic biliary stents on the accuracy of endoscopic ultrasound for pancreatic head cancer staging. | biliary stents have been found to interfere with endoscopic ultrasound (eus) tumor (t) and nodal (n) staging in patients with periampullary cancer. our aim was to determine whether this also occurs in patients with pancreatic head cancer. | 2007 | 17703391 |
| ontogenesis of thyroid function and interactions with maternal function. | fetal and neonatal development of thyroid function involves the embryogenesis, differentiation and maturation of the thyroid gland, of the hypothalamic-pituitary-thyroid axis and of the systems controlling thyroid hormone metabolism. we focus here on aspects related to neurodevelopment. throughout gestation, thyroxine (t4) transferred from the mother, present in embryonic fluids by 4 weeks, protects the fetal brain. free t4 (ft4) in fetal fluids increases rapidly, approaching adult levels by mid ... | 2007 | 17684391 |
| thyroid hormone transporter defects. | in in vitro experiments, active transport of thyroid hormones had been repeatedly demonstrated. the membrane transporters for thyroid hormones which have been identified include the organic anion transporting polypeptide, heterodimeric amino acid transporters and the monocarboxylate transporters (mct) which are the focus of this chapter. the gene encoding mct8 which was identified as a specific thyroid hormone transporter is located on chromosome xq13.2. the expression pattern of mct8 indicates ... | 2007 | 17684393 |
| novel biological and clinical aspects of thyroid hormone metabolism. | intracellular metabolism of thyroid hormone (th) and availability of the active hormone t3 is regulated by three selenoprotein iodothyronine deiodinases (ds). d1 and d2 convert the precursor t4 into the active hormone, t3. d3 is the principal inactivator of t4 and t3 to their respective metabolites, rt3 and t2. while acquired changes in d activities are common, inherited defects in humans were not known. recently, two families with abnormal thyroid function tests, high serum t4, high rt3, low t3 ... | 2007 | 17684394 |
| [hyperlipidemias and dietary patterns: transversal study of japanese brazilians]. | this study aimed at evaluating the association between hyperlipidemia and dietary patterns of japanese brazilians with and without hypothyroidism from bauru, city in the state of são paulo. we evaluated 1,330 individuals by means of demographic and dietary measurement, whom were gotten through standardized questionnaires previously tested. clinical examination and laboratory data were anthropometry, blood pressure, fasting and 2-h glucose load, lipid profile and tsh and free t4. the chi-square a ... | 2007 | 17684615 |