Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| carcinoma showing thymus-like element (castle) of thyroid: combined modality treatment in 3 patients with locally advanced disease. | to examine the value of chemotherapy, radiotherapy and surgery for treatment of locally advanced carcinoma showing thymus-like element (castle) of the thyroid. | 2007 | 17085008 |
| bacteriophage t4 nanoparticle capsid surface soc and hoc bipartite display with enhanced classical swine fever virus immunogenicity: a powerful immunological approach. | the phage t4 hoc, soc bipartite display system is attractive for the expression of cdna and display of peptides or proteins at high copy numbers on the phage capsid surface. until recently, using t4 phage vector to display large foreign molecular immunogens resulted only from either an soc or hoc single site. in this report, the main advantages of the phage t4 system over other display technologies are substantiated by using the phage t4 soc, hoc dual site display vector t4-zh(-) to express: (1) ... | 2007 | 17081627 |
| direct calorimetry of free-moving eels with manipulated thyroid status. | in birds and mammals, the thyroid gland secretes the iodothyronine hormones of which tetraiodothyronine (t4) is less active than triiodothyronine (t3). the action of t3 and t4 is calorigenic and is involved in the control of metabolic rate. across all vertebrates, thyroid hormones also play a major role in differentiation, development and growth. although the fish thyroidal system has been researched extensively, its role in thermogenesis is unclear. in this study, we measured overall heat produ ... | 2007 | 17082966 |
| thyroid function is associated with components of the metabolic syndrome in euthyroid subjects. | thyroid disease and the metabolic syndrome are both associated with cardiovascular disease. | 2007 | 17090642 |
| genetic and environmental interrelations between measurements of thyroid function in a healthy danish twin population. | serum thyrotropin (tsh), free thyroxine (t4), and free triiodothyronine (t3) levels illustrate the thyroid function set point, but the interrelations between these have never been characterized in detail. the aim of this study was to examine the associations between tsh and thyroid hormone levels in healthy euthyroid twins and to determine the extent to which the same genes influence more than one of these biochemical traits; 1,380 healthy euthyroid danish twins (284 monozygotic, 286 dizygotic, ... | 2007 | 17090750 |
| influence of l-thyroxine administration on poor-platelet plasma vegf concentrations in patients with induced short-term hypothyroidism, monitored for thyroid carcinoma. | angiogenesis is a process of new blood vessel development from pre-existing vasculature. it is a crucial process in normal physiology, as well as in several pathological conditions. the vascular endothelial growth factor (vegf) represents a family of specific endothelial cell mitogens, involved in normal angiogenesis and in tumour development. the aim of the present study was to estimate the influence of l-thyroxine (l-t4) administration on poor-platelet plasma (p-pp) vegf concentrations in pati ... | 2007 | 17090953 |
| unexpected peripheral markers of thyroid function in a patient with a novel mutation of the mct8 thyroid hormone transporter gene. | the specific thyroid hormone transporter, mct8, located on the x chromosome, has led to the identification a novel syndrome. the objective is to relate phenotype with several tissue-specific thyroid functions. a 1-year-old boy, who had severe psychological damage and low serum t4, had received l-t4 for 3 months. at admission, body length was normal but weight was low. off therapy, serum tsh was mildly elevated, serum t4 and free t4 were low, and serum t3 and free t3 were high. direct sequencing ... | 2007 | 16974106 |
| professional delay in head and neck cancer patients: analysis of the diagnostic pathway. | the aim of this study was to identify which factors are related to specialist delay and to determine the length of the diagnostic pathway in head and neck cancer patients. three hundred and six patients with a carcinoma of the larynx, pharynx or oral cavity were included in the study. logistic regression analysis was used to identify risk factors for specialist delay. large (t3-t4) tumors showed significantly less specialist delay than small (t1-t2) tumors (p=0.045, odds ratio [or]=0.6). pharyng ... | 2007 | 17005438 |
| spreeta-based biosensor assays for endocrine disruptors. | the construction and performance of an automated low-cost spreeta-based prototype biosensor system for the detection of endocrine disrupting chemicals (edcs) is described. the system consists primarily of a spreeta miniature liquid sensor incorporated into an aluminum flow cell holder, dedicated to support a biacore chip frame, in combination with a simple pressurized air-driven fluid system. during the optimization, a monoclonal antibody (mab)-based immunoassay for the estrogenic compound bisph ... | 2007 | 16971108 |
| induction chemotherapy, concurrent chemoradiation and surgery for pancoast tumour. | the traditional treatment of pancoast tumour with local approaches (surgery, radiotherapy or a combination of both) leads to a poor outcome due to the high rate of incomplete resection and the lack of systemic control. the aim of the present prospective feasibility study was to determine whether a trimodality approach improves local control and survival. patients with stage iib-iiib pancoast tumour received induction chemotherapy (three courses of split-dose cisplatin and etoposide or paclitaxel ... | 2007 | 16971407 |
| in vitro culture, serologic and molecular analysis of acanthamoeba isolated from the liver of a keel-billed toucan (ramphastos sulfuratus). | members of the genus acanthamoeba are usually free-living amebae and are found in a variety of ecological niches including soil, fresh and brackish water, dust in air, filters of heating, ventilating, and air conditioning units, swimming pools and hot tubs, etc. occasionally, they are also known to cause central nervous system infections in humans and other animals. we isolated into culture an amoeba from the liver tissue of a keel-billed toucan and identified it as acanthamoeba sp. based on cul ... | 2007 | 16962705 |
| salt wasting, hypotension, polydipsia, and hyponatremia and the level of spinal cord injury. | case control.objective:to test the reported correlation of hypotension, polydipsia, and hyponatremia with higher levels of spinal cord injury (sci). | 2007 | 17033618 |
| detection of thyroid dysfunction in early pregnancy: universal screening or targeted high-risk case finding? | maternal subclinical hypothyroidism during pregnancy is associated with various adverse outcomes. recent consensus guidelines do not advocate universal thyroid function screening during pregnancy but recommend testing high-risk pregnant women with a personal history of thyroid or other autoimmune disorders or with a family history of thyroid disorders. | 2007 | 17032713 |
| prematurity may be a risk factor for thyroid dysfunction in childhood. | children born prematurely and/or small for gestational age (sga) frequently show disturbances in thyroid function. | 2007 | 17032720 |
| acanthamoeba keratitis due to acanthamoeba genotype t4 in a non-contact-lens wearer in turkey. | an otherwise healthy 22-year-old man presented with acanthamoeba keratitis (ak) in the right eye. he was not a contact lens wearer and had no history of corneal trauma. the acanthamoeba strain isolated from a corneal scraping was identified as morphological group ii and genotype t4. three more acanthamoeba strains isolated from sites of possible human contact with acanthamoebae in the same geographical region, including a lens storage case, tap water and soil, were subjected to morphological and ... | 2007 | 17013653 |
| spontaneous spinal epidural hematoma in a 4-month-old infant. | a case report and a review of literature. | 2007 | 17016493 |
| is time to chemotherapy a determinant of prognosis in advanced-stage ovarian cancer? | clinicians often question when to start chemotherapy after patients undergo surgery for ovarian cancer. a major unproven concern is whether a long postoperative delay reduces the benefits of an extensive procedure and leads to disease progression. our objectives were to evaluate the correlation between clinical and pathologic variables and to evaluate the effect of the "time to chemotherapy" (ttc) interval on survival. | 2007 | 17023033 |
| the role of triiodothyronine-induced substrate cycles in the hepatic response to overnutrition: thyroid hormone as an antioxidant. | overnutrition, by generating reactive oxygen species (ros), produces oxidative stress - an important cause of cellular injury. in the liver, overnutrition begins in the perivenous hepatocytes. to prevent injury, cells must protect themselves against ros accumulation. overnutrition also activates the enzyme deiodinase-1 (d1), which catalyzes the conversion of t4 to t3. d1 is primarily located in the pv region of the liver. thyroid hormone is known to generate substrate cycling. the hypothesis of ... | 2007 | 17023119 |
| paraplegia as the presenting manifestation of extramedullary megakaryoblastic transformation of previously undiagnosed chronic myelogenous leukemia. | extramedullary tumors, also known as granulocytic sarcomas (gs), occur most frequently in acute myelogenous leukemia (aml). they may signal the onset of the accelerated phase of chronic myelogenous leukemia (cml) or the blastic transformation of a myeloproliferative disorder. occasionally, a gs may be the presenting sign of undiagnosed aml, and rarely the presenting sign of undiagnosed cml or aleukemic leukemia. paraplegia due to a spinal cord gs is an extremely rare presentation of undiagnosed ... | 2007 | 17019692 |
| cancer of the gastric stump following distal gastrectomy for cancer. | cancer of the gastric stump (cgs) after distal gastrectomy for cancer has not been characterized in a large study. the aim of this study was to investigate the clinicopathological features and outcome of cgs following distal gastrectomy for cancer. | 2007 | 17054314 |
| surgical management for upper thoracic spine tumors by a transmanubrium approach and a new space. | the anterior aspect of the upper thoracic spine is a difficult region to approach in spinal surgery. many vital structures including osseus, articular, vascular and nervous ones hinder the exposure. with increasing frequency, spine surgeons are being asked to provide decompression and stabilization in patients with spinal tumors. the traditional exposure is between the esophagus and trachea medially and the left common carotid or the brachiocephalic artery (bca) laterally, and the disadvantages ... | 2007 | 17043896 |
| investigation of interleukin 10, 12 and 18 levels in patients with head and neck cancer. | head and neck squamous cell carcinoma (hnscc) is an aggressive epithelial malignancy. it is the most common neoplasm arising in the upper aerodigestive tract. interleukin (il) 12 and il-18 are cytokines which have a major anti-tumour activity via stimulation of a t-helper type 1 (th1) immune response. interleukin 10, a potent antagonist of il-12, is a cytokine which possesses immunosuppressive activity mainly produced via t-helper type 2 (th2) cells. studies of other types of cancer have shown t ... | 2007 | 17040593 |
| post-prandial endothelial dysfunction in hypertriglyceridemic subjects: molecular mechanisms and gene expression studies. | triglyceride-rich lipoproteins (tgrls) are a cardiovascular risk factor and induce endothelial dysfunction. in the present study, we investigated the effects of post-prandial tgrls from type iv hyperlipidemic subjects on endothelial activation addressing the effects of the lipoproteins on intracellular pathways and gene expression. | 2007 | 17055512 |
| the role of postoperative radiation therapy in carcinoma ex pleomorphic adenoma of the parotid gland. | to evaluate the impact of postoperative radiation therapy on the clinical course of patients with carcinoma ex pleomorphic adenoma of the parotid gland. | 2007 | 17049183 |
| structural and functional studies of regb, a new member of a family of sequence-specific ribonucleases involved in mrna inactivation on the ribosome. | the regb endoribonuclease participates in the bacteriophage t4 life cycle by favoring early messenger rna breakdown. regb specifically cleaves ggag sequences found in intergenic regions, mainly in translation initiation sites. its activity is very low but can be enhanced up to 100-fold by the ribosomal 30 s subunit or by ribosomal protein s1. regb has no significant sequence homology to any known protein. here we used nmr to solve the structure of regb and map its interactions with two rna subst ... | 2007 | 17046813 |
| early assessment of hypothalamic-pituitary-gonadal function in patients with congenital hypothyroidism of central origin. | early recognition of gonadotropic dysfunction could enable well-timed growth and maturation and prevent damage to gonads and external genitalia. the adaptation of the dutch neonatal screening program for congenital hypothyroidism in the mid 1990s resulted in enhanced detection of congenital hypothyroidism of central origin (ch-c), with high likelihood of multiple pituitary hormone deficiency, including gonadotropin (gn) deficiency. | 2007 | 17047014 |
| thyroid hormone synthesis and secretion in humans after 80 milligrams of iodine for 15 days and subsequent withdrawal. | in animals, acute iodine administration results in acute intrathyroidal inhibition of iodinations followed by escape of the inhibition if the excessive iodine intake continues. in humans, the intrathyroidal nonhormonal and hormonal iodine concentration after exposure to large doses of iodine for a relatively long period of time is not known. | 2007 | 17047024 |
| single-dose rexinoid rapidly and specifically suppresses serum thyrotropin in normal subjects. | retinoid x receptor agonists (rexinoids) have demonstrated benefit in patients with certain malignancies but appear to cause central hypothyroidism in some patients with advanced cancer. the influence of rexinoids on thyroid function in healthy subjects is not clear. | 2007 | 17062760 |
| thermoplastic patient fixation: influence on chest wall and target motion during radiotherapy of lung cancer. | several methods have been developed to reduce tumor motions and patient movements during radiotherapy of lung cancer. in this study, a multislice ct-based analysis was performed to examine the effect of a thermoplastic patient immobilization system on the chest wall and tumor motions. | 2007 | 17497099 |
| ct-based classification of long spinal allograft fusion. | anterior column reconstruction of the thoracolumbar spine by structural allograft has an increased potential for biological fusion when compared to synthetic reconstructive options. estimation of cortical union and trabecular in-growth is, however, traditionally based on plain radiography, a technique lacking in sensitivity. a new assessment method of bony union using high-speed spiral ct imaging is proposed which reflects the gradually increasing biological stability of the construct. grade i ( ... | 2007 | 17497188 |
| probing dna polymerase-dna interactions: examining the template strand in exonuclease complexes using 2-aminopurine fluorescence and acrylamide quenching. | the bacteriophage t4 dna polymerase forms fluorescent complexes with dna substrates labeled with 2-aminopurine (2ap) in the template strand; the fluorescence intensity depends on the position of 2ap. when preexonuclease complexes are formed, complexes at the crossroads between polymerase and exonuclease complexes, 2ap in the +1 position in the template strand is fully free of contacts with the adjacent bases as indicated by high fluorescence intensity and a long fluorescence lifetime of about 10 ... | 2007 | 17497891 |
| identification of a single hnh active site in type iis restriction endonuclease eco31i. | type iis restriction endonuclease eco31i is a "short-distance cutter", which cleaves dna strands close to its recognition sequence, 5'-ggtctc(1/5). previously, it has been proposed that related endonucleases recognizing a common sequence core gtctc possess two active sites for cleavage of both strands in the dna substrate. here, we present bioinformatic identification and experimental evidence for a single nuclease active site. we identified a short region of homology between eco31i and hnh nucl ... | 2007 | 17499273 |
| an atp hydrolysis sensor in the dna packaging motor from bacteriophage t4 suggests an inchworm-type translocation mechanism. | tailed bacteriophages and large eukaryotic viruses employ powerful molecular motors to translocate dsdna into a preassembled capsid shell. the phage t4 motor is composed of a dodecameric portal and small and large terminase subunits assembled at the special head-tail connector vertex of the prohead. the motor pumps dna through the portal channel, utilizing atp hydrolysis energy provided by an atpase present in the large terminase subunit. we report that the atpase motors of terminases, helicases ... | 2007 | 17428497 |
| thyroid dysfunction associated with increased low-density lipoprotein cholesterol in epileptic children treated with carbamazepine monotherapy: a causal relationship? | lipid abnormalities and thyroid dysfunction have been reported in patients treated with antiepileptic drugs. the aim of this study was to evaluate prospectively the association between thyroid and lipid profile in children treated with carbamazepine (cbz) monotherapy. | 2007 | 17428707 |
| breast-conserving surgery for t3/t4 breast cancer: an analysis of 196 patients. | breast conservation therapy (bct) increases quality of life and self-esteem of breast cancer patients. in special cancer centers up to 90% of patients are treated with bct. t3/t4 breast cancer is one of the few contraindications for bct. however, retrospective data suggest that bct may be eligible in selected cases of t3/t4 breast cancer. | 2007 | 17417725 |
| inhibition of tyrosine kinase-mediated cellular signalling by tyrphostins ag126 and ag556 modulates secondary damage in experimental spinal cord trauma. | protein tyrosine kinases help to regulate the expression of many genes, which play an important role in the pathophysiology of a number of diseases. here we investigate the effects of the tyrosine kinase inhibitors, ag126 and ag556 on the degree of experimental spinal cord trauma induced by the application of vascular clips to the dura via a four-level t4-t8 laminectomy. spinal cord injury in mice resulted in severe trauma characterized by oedema, neutrophil infiltration, production of a range o ... | 2007 | 17418876 |
| renal cell carcinoma clinically involving adjacent organs: experience with aggressive surgical management. | historically, patients with nonmetastatic renal cell carcinoma (rcc) involving adjacent organs have been considered inoperable and incurable. the oncologic efficacy of an aggressive surgical approach was evaluated in a selected subpopulation of rcc patients. further, an attempt was made to define the clinical and pathologic characteristics predictive of surgical failure. | 2007 | 17420980 |
| clearing of suspensions of micrococcus lysodeikticus catalysed by lysozymes from hen, goose, and turkey egg whites, human milk, and phage t4. assessment of potential as signal generators for homogeneous enzyme immunoassays for urinary steroids. | lysozymes (3.2.1.17) from goose (anser anser) egg white, turkey (melagris gallopavo) egg white, phage t4 and human milk were compared with hen egg white lysozyme in their ability to clear a suspension of micrococcus lysodeikticus. all of the lysozymes, except hen egg white lysozyme, catalysed the clearing of the micrococcus lysodeikticus suspension in a biphasic fashion. compared to hen egg white lysozyme, the total absorbance or transmission change over 5 and 20 minutes was less in all cases, e ... | 2007 | 17424827 |
| comparison of seven serum thyroglobulin assays in the follow-up of papillary and follicular thyroid cancer patients. | serum thyroglobulin (tg) is the marker of differentiated thyroid cancer after initial treatment and tsh stimulation increases its sensitivity for the diagnosis of recurrent disease. | 2007 | 17426102 |
| weekly docetaxel with concomitant radiotherapy in patients with inoperable oesophageal cancer. | to evaluate the efficacy and tolerability of weekly docetaxel concurrent with radiotherapy in inoperable oesophageal cancer patients. | 2007 | 17403629 |
| preoperative radio-chemotherapy (rt-ct) in rectal cancer. prospective study with postoperative rt-ct control group. | between 1996 and 2000, the colorectal tumour committee of the hospital universitario de bellvitge and the institut català d'oncologia, hospitalet, carried out a non-randomised prospective study of pre-op radio-chemotherapy (rt-ct) in locally advanced rectal tumours. we herein present the results. on the other hand, and at the same time, patients operated on for locally advanced rectal cancer were admitted and treated by rt-ct during the postoperative process, according to our standard protocol. ... | 2007 | 17403630 |
| interaction between cadmium, lead and potassium fertilizer (k2so4) in a soil-plant system. | a pot experiment was conducted to examine the influence of potassium (k) fertilizer (k(2)so(4)) application on the phytoavailability and speciation distribution of cadmium (cd) and lead (pb) in soil. spring wheat (triticum aestivum l.) was selected as the test plant. there were seven treatments including single and combined contamination of cd and pb. cdcl(2).2.5 h(2)o and pb(no(3))(2) were added to the soil at the following dosages: cd + pb = 0.00 + 0.00, 5.00 + 0.00, 25.0 + 0.00, 0.00 + 500, 0 ... | 2007 | 17404694 |
| coping strategies as determinants of quality of life in stroke patients: a longitudinal study. | quality of life (qol) is reduced for stroke patients and coping strategies have been suggested as determinants of qol. thus far the relationship between coping and qol has only been examined in small-scale cross-sectional designs. therefore, the current study set out to examine this relationship in a longitudinal setting. | 2007 | 17406109 |
| structural determinants of nitroxide motion in spin-labeled proteins: tertiary contact and solvent-inaccessible sites in helix g of t4 lysozyme. | a nitroxide side chain (r1) has been substituted at single sites along a helix-turn-helix motif in t4 lysozyme (residues 114-135). together with previously published data, the new sites reported complete a continuous scan through the motif. mutants with r1 at sites 115 and 118 were selected for crystallographic analysis to identify the structural origins of the corresponding two-component epr spectra. at 115, r1 is shown to occupy two rotamers in the room temperature crystal structure, one of wh ... | 2007 | 17473014 |
| health status, mood, and cognition in experimentally induced subclinical hypothyroidism. | the objective of the study was to determine whether subclinical hypothyroidism causes decrements in health status, mood, and/or cognitive function. | 2007 | 17473069 |
| overexpression of fascin-1 in advanced colorectal adenocarcinoma: tissue microarray analysis of immunostaining scores with clinicopathological parameters. | fascin-1 is an actin-binding protein that promotes cell proliferation, adhesion and motility. we tested the hypothesis that fascin-1 expression correlates with clinicopathological parameters of colorectal adenocarcinomas. | 2007 | 17473384 |
| morphological and physiological development of anterior thoracic stretch receptors in two isopods, armadillidium vulgare and ligia exotica. | abdominal muscle receptor organs (mros) monitor the position and movement of abdomen in crustaceans. thoracic segments of decapods are fused and immovable. it is speculated that mros had retrograded simple shape, n-cells that lost receptor muscles, a receptor cell and accessory nerves. we focused on the effect of segmental movement in respect to thoracic n-cells and mros in isopods that have movable thoracic segments. armadillidium vulgare rolled up its body segments. ligia exotica swam by quick ... | 2007 | 17473927 |
| laparoscopic colectomy in colon cancer. a single-center clinical experience. | aim of our study was to compare the results of the laparoscopic technique to those obtained by traditional open approach in patients with colon cancer. the advantages, disadvantages, and the contraindications (real and presumptive) of this mini-invasive approach are described, by comparing the data obtained from the international literature with our clinical experience. | 2007 | 17475112 |
| [confocal microscopic evaluation of epithelia of the larynx]. | to evaluate mucosal changes of the true vocal cord, e. g. leukoplakia, microlaryngoscopy is needed to obtain tissue for histopathologic investigation. but there is a discrepancy between the amount of representative tissue necessary for pathology and the postoperative voice function. thus, a diagnostic procedure that enables the surgeon to differentiate inflammation from dysplasia and carcinoma in situ intra-operatively is urgently needed. we are now reporting on our results using laser scanning ... | 2007 | 17476630 |
| [regulation of promoter activity through electrostatic interactions with rna-polymerase]. | electrostatic profiles for sigma70-specific promoters of t4 bacteriophage and four consensus-like synthetic promoters have been calculated. it was shown that the promoters can be classified according to the presence of some specific electrostatic elements located in the far upstream region of their dnas. a correlation between the electrostatic elements specific for promoters and their functional behaviour was established. a general scheme of promotor activity regulation through electrostatic int ... | 2007 | 17477049 |
| clinical presentation, management, and outcome of high-grade mucoepidermoid carcinoma of the parotid gland. | to describe clinical features of high-grade (hg) mucoepidermoid carcinoma (mec) of the parotid gland and assess clinical outcomes of one surgical management approach. design/setting/methods: retrospective case series in a tertiary care academic institution. pathology records were reviewed from 1977 to 1997, identifying patients with parotid hg mec. available medical records were reviewed for data on clinical features, treatment, and outcome. | 2007 | 17478216 |
| prognostic significance of surgical margins in transoral co2 laser microsurgery for t1-t4 pharyngo-laryngeal cancers. | histological affected or close margin is an adverse factor in conventional surgery of larynx-hypopharynx cancer. our objective was to analyze the relevance of the margins in transoral laser microsurgery (tlm). a retrospective study of 357 consecutive patients with cancer of the larynx and hypopharynx (t1-t4) treated with tlm. three possible margins were considered: tumor free, affected, and uncertain. an affected margin showed marked tumor infiltration. an uncertain margin was defined when the s ... | 2007 | 17479274 |
| twenty-four hour hormone profiles of tsh, free t3 and free t4 in hypothyroid patients on combined t3/t4 therapy. | the benefits of using thyroxine (t4) plus triiodothyronine (t3) in combination in thyroid hormone replacement are unproven but many individuals continue to be treated with this regime. when t3 is used alone for hypothyroidism, it results in wide fluctuations of thyroid hormone levels. however, only limited data exists on combined t3/t4 therapy. in this study, we have compared 24-hour profiles of thyroid stimulating hormone (tsh), free t4 (ft4) and free t3 (ft3) and cardiovascular parameters in 1 ... | 2007 | 17479444 |
| effects of diet quality on energy budgets and thermogenesis in brandt's voles. | food quality and availability play an important role in an animal's life history. the aim of this study was to examine the effect of diet quality [high-fiber diet (hf) or low-fiber diet (lf)] on energy budgets and thermogenesis in brandt's voles (lasiopodomys (microtus) brandtii). dry matter intake and gross energy intake increased and digestibility decreased in hf voles compared with lf voles, while the digestible energy intake was similar for both hf and lf voles. nonshivering thermogenesis (n ... | 2007 | 17482858 |
| study of prostate cancer pathologic features in chinese populations. | to report the pathologic features of prostate cancer and its clinical outcome in the chinese population in taiwan. | 2007 | 17482934 |
| detecting ultraviolet damage in single dna molecules by atomic force microscopy. | we report detection and quantification of ultraviolet (uv) damage in dna at a single molecule level by atomic force microscopy (afm). by combining the supercoiled plasmid relaxation assay with afm imaging, we find that high doses of medium wave ultraviolet (uvb) and short wave ultraviolet (uvc) light not only produce cyclobutane pyrimidine dimers (cpds) as reported but also cause significant dna degradation. specifically, 12.5 kj/m(2) of uvc and 165 kj/m(2) of uvb directly relax 95% and 78% of p ... | 2007 | 17483180 |
| glucose-6-phosphate dehydrogenase deficiency and kernicterus of south-east anatolia. | we aimed to investigate the rate of kernicterus, and physical and laboratory examination findings in hyperbilirubinemic infants with glucose-6-phosphate dehydrogenase (g-6-pd) deficiency. | 2007 | 17483701 |
| preoperative radiotherapy in elderly patients with rectal cancer. | we performed a retrospective analysis in order to evaluate the compliance with preoperative radiotherapy in patients aged>or=70 with locally advanced resectable rectal cancer, and to evaluate the influence of comorbidities on treatment tolerance and oncological results. | 2007 | 17483785 |
| [intervention of selenium on neurogranin expression in filial cerebrum of mice with excess iodine]. | to study the effects of excess iodine intake on neurogranin expression in cerebrum of filial mice and the intervention of selenium. | 2007 | 17484205 |
| [renal cell carcinoma: prognostic factors and staging]. | to evaluate the prognostic significance of the 2002 tnm tumor classification for renal cell carcinoma, as well as other factors intervening in its survival. | 2007 | 17484480 |
| glycoprotein i of herpes simplex virus type 1 contains a unique polymorphic tandem-repeated mucin region. | glycoprotein i (gi) of herpes simplex virus type 1 (hsv-1) contains a tandem repeat (tr) region including the amino acids serine and threonine, residues that can be utilized for o-glycosylation. the length of this tr region was determined for 82 clinical hsv-1 isolates and the results revealed a polymorphic distribution of two to six or eight repeated blocks with a majority harbouring between two and four repeats. assessment of the o-glycosylation capacity of an acceptor peptide (stpstttstpsttt) ... | 2007 | 17485527 |
| day case breast augmentation under paravertebral blockade: a prospective study of 100 consecutive patients. | an increasing trend toward day surgery management requires plastic surgeons not only to be cognizant of block techniques, but also to assess their safety and efficacy objectively. paravertebral block offers benefits by enhancing surgical anesthesia and postoperative analgesia. this study aimed to assess the safety and efficacy of paravertebral block for day patients undergoing submuscular breast augmentation. the primary outcome measure was the rate of block failure. the secondary outcome measur ... | 2007 | 17486400 |
| reprogramming the trna-splicing activity of a bacterial rna repair enzyme. | programmed rna breakage is an emerging theme underlying cellular responses to stress, virus infection and defense against foreign species. in many cases, site-specific cleavage of the target rna generates 2',3' cyclic phosphate and 5'-oh ends. for the damage to be repaired, both broken ends must be healed before they can be sealed by a ligase. healing entails hydrolysis of the 2',3' cyclic phosphate to form a 3'-oh and phosphorylation of the 5'-oh to form a 5'-po4. here, we demonstrate that a po ... | 2007 | 17488852 |
| c-reactive protein in obese pcos women and the effect of metformin therapy. | elevated c-reactive protein (crp) in association with hyperinsulinemia is a significant risk factor for cardiovascular diseases and that plays a key role in the development of the pcos. we evaluated serum crp level, before and after metformin therapy in obese women with polycystic ovarian syndrome (pcos). thirty five obese women with pcos [bmi=28,2+/-1,84 kg/m2, aged 20-35 years] were studied. patients received metformin orally the dose of 850 mg per day. the patients were carefully interviewed, ... | 2007 | 17489777 |
| [effect of fluid resuscitation on extravascular lung water in early stage of septic shock]. | to determine the effect of fluid resuscitation on extravascular lung water (evlw) in early stage of septic shock. | 2007 | 17490568 |
| upper mediastinal node dissection for hypopharyngeal and cervical esophageal carcinomas. | hypopharyngeal cancer (hpc) and cervical esophageal cancer (ce) are aggressive tumors with a poor prognosis. multiple lymph node metastases often occur in the upper mediastinum, as well as in the neck, and thus upper mediastinal dissection (md) is crucial to improving the cure rate. however, excessive md can increase postoperative morbidity and mortality, making it important to employ the proper technique and appropriate extent of dissection. in the present retrospective study we aimed to determ ... | 2007 | 17491530 |
| structure-function analysis of the 3' phosphatase component of t4 polynucleotide kinase/phosphatase. | t4 polynucleotide kinase/phosphatase (pnkp) exemplifies a family of bifunctional enzymes with 5'-kinase and 3' phosphatase activities that function in nucleic acid repair. t4 pnkp is a homotetramer of a 301-aa polypeptide, which consists of an n-terminal kinase domain of the p-loop phosphotransferase superfamily and a c-terminal phosphatase domain of the dxd acylphosphatase superfamily. the homotetramer is formed via pairs of phosphatase-phosphatase and kinase-kinase homodimer interfaces. here w ... | 2007 | 17493655 |
| successful long-term weight maintenance: a 2-year follow-up. | to find factors associated with successful weight maintenance (wm) in overweight and obese subjects after a very low-calorie diet (vlcd). | 2007 | 17495202 |
| [propositions of interpretative comments for thyroid function tests]. | in the field of thyroid disease, a number of governmental organisms or professional associations have published practice guidelines containing laboratory-related recommendations, eg the haute autorité de la santé (has), or the american thyroid association (ata). among the physicians who prescribe thyroid function tests, all have not read and memorized all these recommendations. in order to help them to better integrate these recommendations in their practice, we have composed a thesaurus of read ... | 2007 | 17502308 |
| favorable clinical heart and bone effects of anti-thyroid drug therapy in endogenous subclinical hyperthyroidism. | although subclinical hyperthyroidism (sch) has been associated with increased risk of osteoporosis and cardiac arrhythmias, its treatment is still controversial. this study was designed as a prospective, randomized, intervention, control-study with a 1-year follow-up in order to investigate whether normalization of serum tsh in sch using methimazole has favorable bone and heart clinical effects. fourteen patients with endogenous sch (not graves' disease) were enrolled, 7 (5 women/2 men; group t) ... | 2007 | 17505157 |
| reciprocal relation of thyroid-stimulating hormone and thyroid-stimulating immunoglobulin in a patient with endogenous subclinical hyperthyroidism. | a 72-year-old white woman with an abnormal serum thyroid-stimulating hormone (tsh) concentration was referred to our facility for a comprehensive evaluation. circulating thyroxine (t4) and free thyroxine (ft4) concentrations were all in the normal range. tri-iodothyronine (t3) concentrations were in the low end or slightly below the normal range. tsh was detectable but was below the limits of the normal range. the patient was clinically euthyroid and was receiving medication only for treatment o ... | 2007 | 17505173 |
| f-18 fluorodeoxy-d-glucose positron emission tomography scan in the initial evaluation of patients with a primary melanoma thicker than 4 mm. | metabolic imaging with f-18 fluorodeoxy-d-glucose positron emission tomography is one of the most sensitive and non-invasive techniques, and has proved useful in melanoma. we designed, in 2004, at the institute gustave roussy, a prospective study to determine the value of f-18 fluorodeoxy-d-glucose positron emission tomography scanning in the detection of regional and/or distant metastasis in 25 new patients referred for the treatment of a primary melanoma thicker than 4 mm (tumor node metastase ... | 2007 | 17505260 |
| prosthetic replacement and tangential resection of the superior vena cava in chest tumors. | infiltration of the superior vena cava (svc) due to advanced non small cell lung cancer (nsclc) or thymoma can be treated by prosthetic replacement or tangential resection. these two technical procedures and their results are described. | 2007 | 17505442 |
| iiib-t4 non-small cell lung cancer: indications and results of surgical treatment. | t4 non-small cell lung cancer (nsclc) is commonly considered a contraindication to surgery, indeed chemo-radiotherapy achieves a poor survival rate. we have reviewed our experience with t4 nsclc patients who underwent surgery with the aim of debating the indications and results of surgical treatment in this highly selected group of patients. | 2007 | 17505443 |
| haemodynamic changes and heart rate variability during midazolam-propofol co-induction. | in a prospective, blind, randomised study, we examined the effects of midazolam-propofol co-induction on haemodynamic (blood pressure, heart rate and stroke volume) and heart rate variability. the latter was measured by spectral analysis using the maximum-entropy method to calculate the following: the low frequency component (lf), which reflects both the cardiac sympathetic and parasympathetic activity, the high frequency component (hf) and entropy, which reflects the cardiac parasympathetic act ... | 2007 | 17506733 |
| [symptomatic intramedullary arachnoid cyst. report of two cases and literature review]. | the objective of this work is to present and discuss the rare situation of curable medullary compression with favorable prognosis. | 2007 | 17507047 |
| retroperitoneal lymph node dissection (rpld) in conjunction with nephroureterectomy in the treatment of infiltrative transitional cell carcinoma (tcc) of the upper urinary tract: impact on survival. | to evaluate the prognostic impact of retroperitoneal lymph node dissection (rpld) performed during nephroureterectomy on time to recurrence and survival in patients with infiltrative transitional cell carcinoma (tcc) of the upper urinary tract. | 2007 | 17507148 |
| a randomized, open-label, crossover study comparing the effects of oral versus transdermal estrogen therapy on serum androgens, thyroid hormones, and adrenal hormones in naturally menopausal women. | to compare the changes induced by oral versus transdermal estrogen therapy on the total and free serum concentrations of testosterone (t), thyroxine (t4), and cortisol (c) and the concentrations of their serum binding globulins sex hormone-binding globulin, thyroxine-binding globulin, and cortisol-binding globulin in naturally menopausal women. | 2007 | 17507833 |
| a curative resection improves the postoperative survival rate even in patients with advanced gallbladder carcinoma. | the aim of this study was to evaluate the results of our series of 90 operations for gallbladder carcinoma according to the japanese society of biliary surgery (jsbs) classification system and to clarify the appropriate surgical strategy for advanced gallbladder carcinoma based on the depth of primary tumor invasion and lymph node metastasis. generally, only a surgical resection can achieve a prognostic improvement of the advanced gallbladder carcinoma. the survival of patients with this neoplas ... | 2007 | 17508256 |
| rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells. | maintenance of apico-basal polarity in normal breast epithelial acini requires a balance between cell proliferation, cell death, and proper cell-cell and cell-extracellular matrix signaling. aberrations in any of these processes can disrupt tissue architecture and initiate tumor formation. here, we show that the small gtpase rap1 is a crucial element in organizing acinar structure and inducing lumen formation. rap1 activity in malignant hmt-3522 t4-2 cells is appreciably higher than in s1 cells, ... | 2007 | 17510404 |
| sphincter-preserving r0 total mesorectal excision with resection of internal genitalia combined with pre- or postoperative chemoradiation for t4 rectal cancer in females. | to evaluate the impact of chemoradiation admi-nistered pre- or postoperatively on prognosis in females following r0 extended resection with sphincter-preserving total mesorectal excision (tme) for locally advanced rectal cancer and to assess the association between chemoradiation and intra- and postoperative variables. | 2007 | 17511034 |
| elevated circulating level of osteopontin is associated with advanced disease state of non-small cell lung cancer. | osteopontin (opn) plays important roles in tumor progression and metastasis through binding to opn receptors such as alpha(v)beta(beta) integrin and cd44, and its overexpression in tumor is associated poor clinical outcome of nsclc patients. circulating opn levels, measured by elisa in 130 nsclc cases that had not been treated for cancer at the time of sampling, were analyzed according to clinical, pathologic parameters and single nucleotide polymorphisms (snps) in the opn gene promoter. advance ... | 2007 | 17513004 |
| correlation between size of renal cell carcinoma and its grade, stage, and histological subtype. | the aim of this study was to determine the correlation between histological subtype, size, grade, and stage of the kidney tumors and to investigate whether a correlation exists between the size of the kidney tumor and its behavior. | 2007 | 17514604 |
| [two cases of hyperthyroidism induced by interferon-alpha therapy for renal cell carcinoma]. | autoimmune thyroid disease is the result of a common side-effect of interferon-alpha (ifn-alpha) used to treat viral hepatitis c; but there have been few reports on thyroid disorders induced by ifn-a that was used to treat renal cell carcinoma. ifn-alpha therapy was conducted on two male patients, 75 and 44 years old, after radical nephrectomy. six and five months, respectively, after this therapy, they complained of weight loss. laboratory evaluation revealed hyperthyroidism; the thyroid stimul ... | 2007 | 17515071 |
| the position of the aorta relative to the spine in patients with left thoracic scoliosis: a comparison with normal patients. | analysis axial magnetic resonance images (mris) identifying the position of the aorta in left thoracic scoliosis and normal patients. | 2007 | 17515808 |
| the position of the aorta relative to the spine: is it mobile or not? | this study analyzes the mobility of the aorta relative to the spine in patients with a herniated thoracic disc requiring surgical intervention. | 2007 | 17515812 |
| rna chaperone activity of l1 ribosomal proteins: phylogenetic conservation and splicing inhibition. | rna chaperone activity is defined as the ability of proteins to either prevent rna from misfolding or to open up misfolded rna conformations. one-third of all large ribosomal subunit proteins from e. coli display this activity, with l1 exhibiting one of the highest activities. here, we demonstrate via the use of in vitro trans- and cis-splicing assays that the rna chaperone activity of l1 is conserved in all three domains of life. however, thermophilic archaeal l1 proteins do not display rna cha ... | 2007 | 17517772 |
| a facile method for attaching nitroxide spin labels at the 5' terminus of nucleic acids. | in site-directed spin labeling (sdsl), a nitroxide moiety containing a stable, unpaired electron is covalently attached to a specific site within a macromolecule, and structural and dynamic information at the labeling site is obtained via electron paramagnetic resonance (epr) spectroscopy. successful sdsl requires efficient site-specific incorporation of nitroxides. work reported here presents a new method for facile nitroxide labeling at the 5' terminus of nucleic acids of arbitrary sizes. t4-p ... | 2007 | 17517787 |
| a three-dimensional evaluation of postoperative swelling following orthognathic surgery at 6 months. | advances in three-dimensional technology have enabled applications for the clinical setting to be created and used in routine diagnosis, treatment planning, and patient education. the objectives of this prospective clinical trial were to determine the volume changes associated with facial swelling following orthognathic surgery. | 2007 | 17519721 |
| [in situ hybridization study on the expression of kiss-1 and kai-1 metastasis suppressor genes in gastric cancer]. | to investigate the mrna levels of kiss-1 and kai-1 metastasis suppressor genes in gastric cancer, and to explore its clinical value. | 2007 | 17520389 |
| s-100b release during carotid endarterectomy under local anesthesia. | the neuronal protein s-100b has been found to be an indicator of cellular brain damage. the aim of the study was to evaluate whether cross-clamping of the carotid artery for carotid endarterectomy (cea) under local anesthesia is associated with the same s-100b release pattern as during general anesthesia, where an increase in s-100b concentration in the jugular vein blood of 120% has been reported. in 45 consecutive patients undergoing cea under local anesthesia, serum s-100b samples were drawn ... | 2007 | 17521874 |
| staging of hepatocellular carcinoma: assessment of the japanese tnm and ajcc/uicc tnm systems in a cohort of 13,772 patients in japan. | the aims of this study were to present evidence to develop and validate the japanese tumor-node-metastasis (tnm) staging system for primary liver cancer and to compare its discriminatory ability and predictive power with those of vauthey's simplified staging, which was adopted as the tnm staging system of the american joint committee on cancer (ajcc)/international union against cancer (uicc). | 2007 | 17522517 |
| stability following combined orthodontic-surgical treatment for skeletal anterior open bite - a cephalometric 15-year follow-up study. | the aim of the present study was to evaluate the long-term skeletal and dento-alveolar stability 15 years after combined orthodontic and surgical correction of skeletal anterior open bite. | 2007 | 17522808 |
| metastasis in para-aortic lymph nodes in patients with advanced gastric cancer, treated with extended lymphadenectomy. | lymph node dissection is an essential component of curative resection for advanced gastric cancer. to improve the survival of n2 patients, asian surgeons have been performing d2+para-aortic lymph node dissection. the current study presents the results of lymph node status from multicenter trial of d2 and d2 + para-aortic nodal (no.16) dissection (d4 dissection). | 2007 | 17523339 |
| [effect of losartan on the state of kidney function in rats with experimental hyperthyroidism]. | the effect of losartan on the functional state of kidneys was studied in white rats with the experimental hyperthyroidism caused by a 5-day oral administration exogenous t4 thyroxine in a dose of 50 microg/(100 g body weight). then, the test rats were divided into two groups and animals in the first group received water, while animals in the second group were treated with a losartan solution (10 mg/1) during 24 hours. then, the function of kidneys was studied under the condition of 5% water load ... | 2007 | 17523456 |
| triplet excited fluoroquinolones as mediators for thymine cyclobutane dimer formation in dna. | a series of fluoroquinolones (fqs), including enoxacin (enx), pefloxacin (pfx), norfloxacin (nfx), its n(4')-acetyl derivative (anfx), ofloxacin (ofx), and rufloxacin (rfx) have been investigated to determine their potential as dna photosensitizers via thymine cyclobutane dimer (t<>t) formation in dna. at fluoroquinolone concentrations and light doses insufficient to produce direct single strand breaks, enx, pfx, and nfx were able to produce t<>t dimers in dna, revealed by enzymatic treatment wi ... | 2007 | 17523621 |
| altered cardiovascular vagal responses in nonelderly female patients with subclinical hyperthyroidism and no apparent cardiovascular disease. | subclinical hyperthyroidism (sh) has been associated with exercise intolerance, changes in cardiac morphology, atrial arrhythmias and sympathovagal imbalance. the aim of this study was to evaluate the vagal reserve and modulation by a sympathetic stimulus in nonelderly patients with sh without cardiovascular problems. | 2007 | 17524031 |
| the rationale for radical cystectomy as primary therapy for t4 bladder cancer. | treatment of t4 bladder cancer patients remains a clinical challenge. conservative management is often insufficient regarding local control, neoadjuvant chemotherapy delays definite treatment while leading to increased therapy-associated morbidity and mortality during the course of the disease. primary cystectomy has also been reported to be associated with a high complication rate and unsatisfactory clinical efficacy. herein, we report postoperative outcome, including therapy-related complicati ... | 2007 | 17525849 |
| inactivation of e. coli, b. subtilis spores, and ms2, t4, and t7 phage using uv/h2o2 advanced oxidation. | the goal of this study was to evaluate the potential of an advanced oxidation process (aop) for microbiocidal and virucidal inactivation. the viruses chosen for this study were bacteriophage ms2, t4, and t7. in addition, bacillus subtilis spores and escherichia coli were studied. by using h(2)o(2) in the presence of filtered ultraviolet (uv) irradiation (uv/h(2)o(2)) to generate wavelengths above 295nm, the direct uv photolysis disinfection mechanism was minimized, while disinfection by h(2)o(2) ... | 2007 | 17532124 |
| evidence-based radiation oncology: definitive, adjuvant and salvage radiotherapy for non-metastatic prostate cancer. | the standard treatment options based on the risk category (stage, gleason score, psa) for localized prostate cancer include surgery, radiotherapy and watchful waiting. the literature does not provide clear-cut evidence for the superiority of surgery over radiotherapy, whereas both approaches differ in their side effects. the definitive external beam irradiation is frequently employed in stage t1b-t1c, t2 and t3 tumors. there is a pretty strong evidence that intermediate- and high-risk patients b ... | 2007 | 17532494 |