Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| coronary flow reserve is impaired in patients with adult growth hormone (gh) deficiency. | relationship between adult growth hormone deficiency (aghd) and increased cardiovascular disease risk is very well known in hypopituitary patients treated with conventional hormone replacement therapy other than growth hormone (gh) administration. endothelial dysfunction, an early and reversible event in pathogenesis of atherosclerosis, is associated with increased vascular smooth muscle tone, arterial stiffening and intima-media thickness (imt). coronary flow reserve (cfr) measurement by transt ... | 2007 | 17371470 |
| well-being, health-related quality of life and cardiovascular disease risk profile in women with subclinical thyroid disease - a community-based study. | the aim of this study was to evaluate whether subclinical thyroid disease is associated with impaired health-related quality of life and a more adverse cardiovascular disease risk profile. | 2007 | 17371474 |
| middle promoters constitute the most abundant and diverse class of promoters in bacteriophage t4. | the temporally regulated transcription program of bacteriophage t4 relies upon the sequential utilization of three classes of promoters: early, middle and late. here we show that middle promoters constitute perhaps the largest and the most diverse class of t4 promoters. in addition to 45 t4 middle promoters known to date, we mapped 13 new promoters, 10 of which deviate from the consensus mota box, with some of them having no obvious match to it. so, 30 promoters of 58 identified now deviate from ... | 2007 | 17371501 |
| small interfering rna-mediated caveolin-1 knockout on plasminogen activator inhibitor-1 expression in insulin-stimulated human vascular endothelial cells. | using human vascular endothelial cells (ecv304) as the target, we studied the effect of caveolin (cav)-1 in the course of insulin-stimulated expression of plasminogen activator inhibitor (pai)-1. the appropriate single-stranded oligonucleotides representing the rnai cav-1 gene were analyzed by ambion software. after annealing to generate double-stranded oligonucleotides (ds oligo), it was cloned into the pentr/u6 entry vector containing rna polymerase iii expression element by t4 dna ligase. the ... | 2007 | 17342262 |
| effects of long term iodized table salt consumption on serum t3, t4 and tsh in an iodine deficient area of bangladesh. | the effect of iodized and non-iodized table salt in goiter hyper-endemic area on the thyroid gland and its hormones t3, t4 and thyroid stimulating hormone (tsh) were studied in two hundred subjects from the center for nuclear medicine and ultrasound, mymensingh. iodized and non-iodized salt users were called study and control groups respectively. the mean concentration of t3 were 2.38 nmol/l and 2.22 nmol/l & t4 concentration were 128.67 and 123.72 nmol/l in the study and control group respectiv ... | 2007 | 17344781 |
| survival of patients with transitional cell carcinoma of the ureter and renal pelvis in balkan endemic nephropathy and non-endemic areas of serbia. | to evaluate the characteristics and survival of patients with upper urinary tract (uut) transitional cell carcinoma (tcc) in serbia, followed for >/=5 years or until death. | 2007 | 17346272 |
| hyperthyroidism in molar pregnancy: rapid preoperative preparation by plasmapheresis and complete improvement after evacuation. | human chorionic gonadotropin bears structural homology to pituitary thyrotropin. the extremely elevated levels of human chorionic gonadotropin in patients with molar pregnancy or other trophoblastic diseases can lead to hyperthyroidism. we describe a patient with molar pregnancy who had secondary hyperthyroidism prepared rapidly by plasmapheresis for surgery. the clinical picture improved dramatically after the first plasmapheresis. three subsequent plasmapheresis provided a 75.1% decrease in se ... | 2007 | 17346650 |
| multiple origins of replication contribute to a discontinuous pattern of dna synthesis across the t4 genome during infection. | chromosomes provide a template for a number of dna transactions, including replication and transcription, but the dynamic interplay between these activities is poorly understood at the genomic level. the bacteriophage t4 has long served as a model for the study of dna replication, transcription, and recombination, and should be an excellent model organism in which to integrate in vitro biochemistry into a chromosomal context. as a first step in characterizing the dynamics of chromosomal transact ... | 2007 | 17346743 |
| beclomethasone dipropionate versus mesalazine in distal ulcerative colitis: a multicenter, randomized, double-blind study. | topical beclomethasone diproprionate has shown efficacy in ulcerative colitis. | 2007 | 17347061 |
| significance of lymphangiogenesis as assessed by immunohistochemistry for podoplanin in patients with esophageal carcinoma. | although lymph node involvement is an important prognostic factor for survival in patients with esophageal carcinoma, little is known about lymphangiogenesis in esophageal carcinoma. podoplanin, a mutin-type transmembrane glycoprotein, specifically recognizes the lymphatic endothelium and is used as a lymphatic-specific marker. anti-human podoplanin antibody was therefore used to quantify and evaluate the lymphangiogenesis in esophageal carcinoma. | 2007 | 17348451 |
| maternal leptin treatment during lactation programs the thyroid function of adult rats. | recently, we showed that both maternal malnutrition during lactation and leptin treatment during the neonatal period program thyroid function. in this study we evaluate whether maternal leptin treatment during lactation programs thyroid function of the offspring in the adulthood. the dams were divided into 2 groups: lep-daily sc single injected with 8 microg/100 g of body weight with recombinant rat leptin during the last 3 days of lactation and control group (c) that received the same volume of ... | 2007 | 17349662 |
| nt-probnp changes, oxidative stress, and energy status of hypertrophic myocardium following ischemia/reperfusion injury. | n-terminal pro-b-type natriuretic peptide (nt-probnp) is a sensitive functional marker in heart disease, including left ventricular hypertrophy (lvh) secondary to valvular aortic stenosis (as). we evaluated the association between nt-probnp changes, oxidative stress, energy status and severity of lvh in patients with as. ten patients undergoing aortic valve replacement for as were studied. plasma nt-probnp concentrations were performed by electroluminescence immunoassay 15min after the induction ... | 2007 | 17350221 |
| spinal cord infarction with multiple etiologic factors. | spinal cord infarction is uncommon and usually presents with sudden onset of paralysis and sensory disturbances. a variety of causes are described, but rarely with multiple factors involved. we report a case of a 63-year-old man with a history of diabetes mellitus, hypertension, and osteoarthritis who presented with acute onset of chest pain, numbness, and weakness associated with episodic hypotension. he had incomplete tetraplegia and was areflexic without spasticity. pain and temperature sensa ... | 2007 | 17351858 |
| higher radiation dose with a shorter treatment duration improves outcome for locally advanced carcinoma of anal canal. | to assess whether radiation dose and duration of treatment influence local control and survival of patients with locally advanced anal cancer treated with definitive chemoradiation. | 2007 | 17352019 |
| thyroid-stimulating hormone restores bone volume, microarchitecture, and strength in aged ovariectomized rats. | we show the systemic administration of low levels of tsh increases bone volume and improves bone microarchitecture and strength in aged ovx rats. tsh's actions are mediated by its inhibitory effects on rankl-induced osteoclast formation and bone resorption coupled with stimulatory effects on osteoblast differentiation and bone formation, suggesting tsh directly affects bone remodeling in vivo. | 2007 | 17352644 |
| sequential use of aminophylline and theophylline for the treatment of atropine-resistant bradycardia after spinal cord injury: a case report. | a 66-year-old japanese man was brought to our emergency department after he was accidentally compressed into a lateral groove. physical examination revealed pinprick sensory level of t4 and motor level of c7. on the 4th hospital day, electrocardiography suddenly showed sinus bradycardia of 33 beats/min. bolus injection of 0.5 mg of atropine sulphate was not effective. bolus injection of aminophylline was administered followed by continuous infusion. his heart rate increased and remained stable a ... | 2007 | 17354583 |
| euthyroid sick syndrome and cardiac failure in zaria, nigeria. | the study was aimed at establishing the existence of sick euthyroid syndrome in our patients with cardiac failure and to find out whether the syndrome in the our patients has a peculiar pattern | 2007 | 17356583 |
| health status, psychological symptoms, mood, and cognition in l-thyroxine-treated hypothyroid subjects. | many hypothyroid subjects receiving l-thyroxine (l-t4) complain of psychological symptoms or cognitive dysfunction. however, there is limited validated information on these self-reports. | 2007 | 17381359 |
| low prevalence of hypothyroidism among black and mulatto people in a population-based study of brazilian women. | objective african-americans have been shown to have low prevalence of hypothyroidism. brazil has a high ethnic admixture allowing further exploration into whether environmental factors can explain the ethnic differences. design a survey, representative of the population of rio de janeiro, a large metropolitan city in brazil. factors studied included race, parity, income, schooling, and smoking. population the survey was carried out in rio de janeiro whereby households (1500) were selected using ... | 2007 | 17381480 |
| prediagnostic prostate-specific antigen velocity and probability of detecting high-grade prostate cancer. | men with high-grade prostate cancer experience a survival benefit when androgen suppression therapy is combined with radiotherapy (rt) compared with rt alone. we evaluated whether an association exists between the pretreatment prostate-specific antigen (psa) velocity and high-grade prostate cancer at diagnosis, controlling for known predictors of high-grade disease. | 2007 | 17382156 |
| awake pulmonary metastasectomy. | general anesthesia with single-lung ventilation and bimanual lung palpation is considered mandatory in pulmonary metastasectomy. we assessed the safety, feasibility, and early results of awake pulmonary metastasectomy under sole thoracic epidural anesthesia. | 2007 | 17382634 |
| molecular alterations associated with bladder cancer progression. | clinically, superficial tumors (stages ta, tis, and t1) account for 75% to 85% of bladder neoplasms, while the remaining 15% to 25% are invasive (t2, t3, t4) or metastatic lesions at the time of initial presentation. more than 70% of patients with superficial tumors will have one or more recurrences after initial treatment, and about one third of those patients will progress and eventually die of the disease. new methods are needed to identify and monitor patients presenting with "high-risk" sup ... | 2007 | 17382791 |
| high-frequency phage-mediated gene transfer among escherichia coli cells, determined at the single-cell level. | recent whole-genome analysis suggests that lateral gene transfer by bacteriophages has contributed significantly to the genetic diversity of bacteria. to accurately determine the frequency of phage-mediated gene transfer, we employed cycling primed in situ amplification-fluorescent in situ hybridization (cprins-fish) and investigated the movement of the ampicillin resistance gene among escherichia coli cells mediated by phage at the single-cell level. phages p1 and t4 and the newly isolated e. c ... | 2007 | 17384307 |
| lymph node clearance after total mesorectal excision for rectal cancer: laparoscopic versus open approach. | laparoscopic resection of the rectum is still under scrutiny for its adequacy of oncological clearance. | 2007 | 17384514 |
| frequent silencing of runx3 in esophageal squamous cell carcinomas is associated with radioresistance and poor prognosis. | radiotherapy is an effective treatment for some esophageal cancers, but the molecular mechanisms of radiosensitivity remain unknown. runx3, a novel tumor suppressor of gastric cancer, functions in transforming growth factor (tgf)-beta-dependent apoptosis. we obtained paired samples from 62 patients with advanced esophageal cancers diagnosed initially as t3 or t4 with image diagnosis; one sample was obtained from a biopsy before presurgical radiotherapy, and the other was resected in surgical spe ... | 2007 | 17384682 |
| the structure of the atpase that powers dna packaging into bacteriophage t4 procapsids. | packaging the viral genome into empty procapsids, an essential event in the life cycle of tailed bacteriophages and some eukaryotic viruses, is a process that shares features with chromosome assembly. most viral procapsids possess a special vertex containing a dodecameric portal protein that is used for entry and exit of the viral genome. the portal and an atpase are parts of the genome-packaging machine. the atpase is required to provide energy for translocation and compaction of the negative c ... | 2007 | 17386269 |
| molecular characterization of t4-type bacteriophages in a rice field. | bacteriophages, the viruses that infect bacteria, are the most abundant biological entities in the biosphere and play a key role in global biogeochemical cycling. all t4-type bacteriophage isolates tested so far have a conserved genetic module that encodes the virion components including gene 23 (g23), the major capsid protein. molecular analysis of the g23 sequence revealed a remarkable level of diversity of t4-type bacteriophages isolated from rice straw and surface soil in a japanese rice fie ... | 2007 | 17359280 |
| frequent allelic loss at the fra3b site in endemic nasopharyngeal carcinoma: association with clinical features and epstein-barr virus infection. | in this study, we aimed to precisely define the patterns of allelic loss at the fra3b site in endemic nasopharyngeal carcinoma and to determine whether an association exists between allelic loss, clinicopathological features and epstein-barr virus infection. we examined the loss of heterozygosity in 40 cases of nasopharyngeal carcinoma from an endemic area in southern china, using eight high dense, polymorphic, microsatellite markers within or flanking the fra3b site. loss of heterozygosity at t ... | 2007 | 17359554 |
| purification of host cell enzymes involved in adeno-associated virus dna replication. | adeno-associated virus (aav) replicates its dna by a modified rolling-circle mechanism that exclusively uses leading strand displacement synthesis. to identify the enzymes directly involved in aav dna replication, we fractionated adenovirus-infected crude extracts and tested them in an in vitro replication system that required the presence of the aav-encoded rep protein and the aav origins of dna replication, thus faithfully reproducing in vivo viral dna replication. fractions that contained rep ... | 2007 | 17360744 |
| molecular characterization of bacterial endosymbionts of acanthamoeba isolates from infected corneas of korean patients. | the endosymbionts of 4 strains of acanthamoeba (ka/e9, ka/e21, ka/e22, and ka/e23) isolated from the infected corneas of korean patients were characterized via orcein stain, transmission electron microscopic examination, and 16s rdna sequence analysis. double membrane-bound, rod-shaped endosymbionts were distributed randomly throughout both the trophozoites and cysts of each of acanthamoeba isolates. the endosymbionts of ka/e9, ka/e22, and ka/e23 were surrounded by electron-translucent areas. no ... | 2007 | 17374972 |
| [relationship between heart rate variability and serum levels of thyroid hormones, cortisol and prognosis in patients with systemic inflammatory response syndrome]. | to explore the relationship of autonomic nerve system regulation function in patients with systemic inflammatory response syndrome (sirs) to hypothalamo-pituitary-adrenal axis and to find useful markers to predict the prognosis of patients with sirs. | 2007 | 17376271 |
| [construction of the prokaryotic expression vector for human amelogenin gene]. | to construct the prokaryotic expression vector for the gene encoding human amelogenin mature peptide. | 2007 | 17377708 |
| interleukin-6 enhancement after direct autologous retransfusion of shed thoracic blood does not influence haemodynamic stability following coronary artery bypass grafting. | direct autologous retransfusion of shed thoracic blood is carried out to reduce homologous transfusion after cardiac surgery, but it contains high concentrations of inflammatory mediators. the purpose of the study was to investigate whether retransfusion of shed thoracic blood induces plasma interleukin-6 (il-6) expression and influences haemodynamics. | 2007 | 17377856 |
| is a thymine dimer replicated via a transient abasic site intermediate? a comparative study using non-natural nucleotides. | uv light causes the formation of thymine dimers that can be misreplicated to induce mutagenesis and carcinogenesis. this report describes the use of a series of non-natural indolyl nucleotides in probing the ability of the high-fidelity bacteriophage t4 dna polymerase to replicate this class of dna lesion. kinetic data reveal that indolyl analogues containing large pi-electron surface areas are incorporated opposite the thymine dimer almost as effectively as an abasic site, a noninstructional le ... | 2007 | 17378586 |
| long-term results of chemoradiotherapy for locally advanced esophageal cancer, using daily low-dose 5-fluorouracil and cis-diammine-dichloro-platinum (cddp). | we evaluated the efficacy and toxicity of radiation combined with daily, low-dose protracted chemotherapy for locally advanced esophageal cancer. | 2007 | 17380437 |
| effects of bone marrow cell transplant on thyroid function in an i131-induced low t4 and elevated tsh rat model. | we developed a study using low dose radioactive iodine creating an animal model of transient elevation of thyroid stimulating hormone (tsh). male derived bone marrow cells were transplanted to asses their effect on thyroid function and their capability to repair the thyroid parenchyma. | 2007 | 17233913 |
| patterns of nodal relapse after surgery and postoperative radiation therapy for carcinomas of the major and minor salivary glands: what is the role of elective neck irradiation? | to evaluate the incidence of nodal relapses from carcinomas of the salivary glands among patients with clinically negative necks in an attempt to determine the potential utility of elective neck irradiation (eni). | 2007 | 17234357 |
| hydrolytic cleavage of dna by quercetin manganese(ii) complexes. | quercetin manganese(ii) complexes were investigated focusing on its dna hydrolytic activity. the complexes successfully promote the cleavage of plasmid dna, producing single and double dna strand breaks. the amount of conversion of supercoiled form (sc) of plasmid dna to the nicked circular form (nc) depends on the concentration of the complex as well as the duration of incubation of the complexes with dna. the maximum rate of conversion of the supercoiled form to the nicked circular form at ph ... | 2007 | 17234390 |
| p38-mapk induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and atpase activity. | our objective in work presented here was to understand the mechanisms by which activated p38alpha mapk depresses myocardial contractility. to test the hypothesis that activation of p38 mapk directly influences sarcomeric function, we used transgenic mouse models with hearts in which p38 mapk was constitutively turned on by an upstream activator (mkk6be). these hearts demonstrated a significant depression in ejection fraction after induction of the transgene. we also studied hearts of mice expres ... | 2007 | 17234967 |
| induction chemoradiation and surgical resection for superior sulcus non-small-cell lung carcinomas: long-term results of southwest oncology group trial 9416 (intergroup trial 0160). | traditional treatment for superior sulcus non-small-cell lung cancers (ss nsclc), radiation plus surgery, yields a 50% rate of complete resection and a 30% 5-year survival. on the basis of improved outcomes in other subsets of stage iii nsclc, this trial tested the feasibility of induction chemoradiotherapy for ss nsclc. | 2007 | 17235046 |
| mortality and causes of death after multimodality treatment for advanced oral and oropharyngeal cancer. | to analyze mortality and causes of death in patients who received preoperative radiochemotherapy and underwent radical surgery for advanced oral or oropharyngeal cancer. | 2007 | 17236930 |
| surgical management of lung cancer invading the aorta or the superior vena cava. | invasion of mediastinal structures (t4) is considered as an absolute contraindication to surgical management of non-small cell lung cancer (nsclc). the authors studied the role of surgical treatment in case of direct aortic and superior venous caval involvement. | 2007 | 17229487 |
| [case of acute hepatitis associated with basedow's disease]. | a 20-year-old woman given a diagnosis of hyperthyroidism (basedow's disease) had been subsequently treated with methimazole since 1999. as she could not be made euthyroid, surgery was planned to relieve the symptoms. because of liver dysfunction after discontinuation of methimazole and administration of iodine, she was admitted to the hospital. she was negative for hepatitis a, b and c virus serologies, but positive for anti-nuclear antibodies. a liver biopsy, which showed features of chronic ac ... | 2007 | 17230007 |
| symptomatic ascites in a patient with hypothyroidism of short duration. | symptomatic ascites as a presenting symptom of hypothyroidism is quite rare. in most of the case reports, patients with ascites requiring therapeutic abdominal paracentesis have long-standing hypothyroidism. we present a case of symptomatic ascites in a subject with hypothyroidism following radioiodine therapy for graves disease. a 70-year-old african-american man presented with increasing weakness, shortness of breath, weight gain, constipation, and abdominal distention. past history was signif ... | 2007 | 17220693 |
| detection of disseminated pancreatic cells by amplification of cytokeratin-19 with quantitative rt-pcr in blood, bone marrow and peritoneal lavage of pancreatic carcinoma patients. | to evaluate the diagnostic potential of cytokeratin-19 (ck-19) mrna for the detection of disseminated tumor cells in blood, bone marrow and peritoneal lavage in patients with ductal adenocarcinoma of the pancreas. | 2007 | 17226905 |
| encapsulated magnetic nanoparticles as supports for proteins and recyclable biocatalysts. | this paper describes the bioconjugation of histidine-tagged enzymes and other proteins to the surface of composite "magnetomicelles" consisting of magnetic gamma-fe2o3 nanoparticles encapsulated within cross-linked polystyrene-block-polyacrylate copolymer micelle shells. free carboxylic acid groups on the magnetomicelle surface were converted to cu2+-iminodiacetic acid (ida) for protein capture. the conjugation of t4 dna ligase and enhanced green fluorescent protein to magnetomicelles revealed t ... | 2007 | 17226972 |
| concurrent chemoradiation for patients with squamous cell carcinoma of the cervical esophagus. | little is known concerning the role of concurrent chemoradiation (ccrt) in the management of carcinoma of the cervical esophagus. we retrospectively evaluated our treatment approach for patients with cervical esophageal cancer with special emphasis on ccrt with or without surgery. medical records of 21 consecutive patients with cervical esophageal carcinoma treated mainly with ccrt (1997-2004) were reviewed, and factors that influenced patient survival were analyzed retrospectively. nineteen rec ... | 2007 | 17227304 |
| mitochondrial dna variants in bulgarian patients affected by multiple sclerosis. | the occurrence of multiple sclerosis (ms) in subjects clustering to a particular mitochondrial dna (mtdna) haplogroup/haplotype or carrying mtdna mutations associated with leber's hereditary optic neuropathy (lhon) has suggested that mitochondrial genome may contribute to susceptibility to ms. in the present study, 58 unrelated bulgarian patients with relapsing remitting form of ms and 104 randomly selected healthy individuals were analysed for the presence of 14 mtdna polymorphisms determining ... | 2007 | 17222112 |
| t3 replacement does not prevent excitotoxic cell death but reduces developmental neuronal apoptosis in newborn mice. | periventricular leukomalacia (pvl) is a major cause of neurological handicap in pre-term infants. at present, there are no effective or causal therapies available. thyroid hormones play an essential role in brain development and are reported to be decreased in pre-terms and following brain injury in adults. | 2007 | 17222575 |
| molecular identification of free-living amoebae of the vahlkampfiidae and acanthamoebidae isolated in arizona (usa). | sediment samples from rivers, canals and lakes in arizona (usa) were cultured for free-living amoebae at three different incubation temperatures (22, 37 and 40 degrees c). isolates belonging to the vahlkampfiidae were identified by sequencing the pcr-amplified its1, 5.8s and its2 rdna. with this molecular method three naegleria spp. were identified, n. gruberi sensu stricto, n. australiensis and n. tihangensis. also a strain each of willaertia magna and vahlkampfia avara were identified. three s ... | 2007 | 17222746 |
| disrupting effects of hydroxy-polychlorinated biphenyl (pcb) congeners on neuronal development of cerebellar purkinje cells: a possible causal factor for developmental brain disorders? | polychlorinated biphenyls (pcbs) and hydroxy-pcb (oh-pcb) metabolites are widely distributed bioaccumulative environmental chemicals and have similar chemical structures to those of thyroid hormones (ths). previously, we reported that ths are essential for neuronal development and the low doses of two oh-pcbs, namely, 4-oh-2',3,3',4',5'-pentachlorobiphenyl (4'-oh-pecb-106) and 4-oh-2',3,3',4',5,5'-hexachlorobiphenyl (4'-oh-hxcb-159), inhibited the th-dependent dendritic development of purkinje c ... | 2007 | 17223178 |
| skeletal changes after modified intraoral vertical ramus osteotomy for correction of mandibular prognathism. | orthognathic surgery is widely used to correct congenital and acquired dentofacial discrepancies. various surgical procedures have been advocated for correction of mandibular prognathism. in this study, a modified intraoral vertical ramus osteotomy has been developed for surgical correction of mandibular prognathism. the aim of this study is to identify contributing factors to skeletal change by analysing cephalometric changes after modified intraoral vertical ramus osteotomy. | 2007 | 17223511 |
| [msct for staging and response evaluation of esophageal cancer]. | squamous cell carcinomas and adenocarcinomas account for the majority of cases of esophageal cancer. esophageal cancer often is diagnosed in advanced stages as clinical symptoms are lacking in early stages. the major aims of imaging in esophageal cancer are to determine local tumor extension (t and n staging), to rule out systemic disease (m staging), and to assess response to neoadjuvant therapy (response evaluation). ct is still inferior to endoscopic ultrasound in differentiating t stages and ... | 2007 | 17225186 |
| mycosis fungoides--a review of the management of 28 patients and of the recent literature. | mycosis fungoides is an uncommon cutaneous t-cell lymphoma characterized by malignant monoclonal proliferation of t-helper lymphocytes. its course is variable with a potential for lymphatic and hematogenous involvement. we report the investigations, staging, treatment, follow-up, and outcome of 28 patients. this is the first such study reported from ireland. | 2007 | 17214715 |
| the lectin domains of polypeptide galnac-transferases exhibit carbohydrate-binding specificity for galnac: lectin binding to galnac-glycopeptide substrates is required for high density galnac-o-glycosylation. | initiation of mucin-type o-glycosylation is controlled by a large family of udp galnac:polypeptide n-acetylgalactosaminyltransferases (galnac-transferases). most galnac-transferases contain a ricin-like lectin domain in the c-terminal end, which may confer galnac-glycopeptide substrate specificity to the enzyme. we have previously shown that the lectin domain of galnac-t4 modulates its substrate specificity to enable unique galnac-glycopeptide specificities and that this effect is selectively in ... | 2007 | 17215257 |
| insular carcinomas of the thyroid exhibit poor prognosis and long-term survival in comparison to follicular and papillary t4 carcinomas. | insular thyroid carcinoma was described as a tumor with aggressive behavior, and patients usually present themselves with an advanced tumor stage. whether the insular component is an independent factor for poor prognosis remains unclear. therefore, in the present study, we compared the survival of patients with advanced insular, follicular, and papillary thyroid cancer. | 2007 | 17216284 |
| semi-invasive monitoring of cardiac output by a new device using arterial pressure waveform analysis: a comparison with intermittent pulmonary artery thermodilution in patients undergoing cardiac surgery. | thermodilution technique using a pulmonary artery catheter (pac) is a widely used method to determine cardiac output (co). it is increasingly criticized because of its invasiveness and its unclear risk-benefit ratio. thus, less invasive techniques for measuring co are highly desirable. we compared a new, semi-invasive device (flotrac/vigileo) using arterial pressure waveform analysis for co measurement in patients undergoing cardiac surgery with bolus thermodilution measurements. | 2007 | 17218375 |
| effects of epidural anaesthesia on surgical stress-induced immunosuppression during upper abdominal surgery. | previously, we have demonstrated that surgical stress rapidly induced transient hyporesponsiveness of blood cells to endotoxin and that monocyte mcd14 and hla-dr expression decreased soon after the start of surgery under general anaesthesia. this study was designed to investigate the effects of epidural anaesthesia on surgical stress-induced immunosuppression in patients undergoing upper abdominal surgery. | 2007 | 17218378 |
| biochemical severity of thyroid ectopia in congenital hypothyroidism demonstrates sexual dimorphism. | a recent study suggested that sexual dimorphism affects initial thyroid function in congenital hypothyroidism (ch) but differs according to aetiology of ch. aims: to determine if sexual dimorphism was associated with biochemical severity of ch and its aetiology in our large british population. | 2007 | 17218725 |
| a randomized trial of t3-t4 versus t4 sympathectomy for isolated axillary hyperhidrosis. | video-assisted thoracic sympathectomy (vats) is one minimally invasive definitive treatment for axillary hyperhidrosis. different techniques exist for controlling axillary sudoresis, but they are temporary and have high cost. this study was conducted to compare the initial results from sympathectomy using two distinct levels for treating axillary sudoresis: t3-t4 vs t4. | 2007 | 17210397 |
| sexual dimorphism in thyroid function and type 1 iodothyronine deiodinase activity in pre-pubertal and adult rats. | iodothyronine deiodinase activities are regulated by sex steroids; however, the mechanisms underlying the reported sexual dimorphism are poorly defined. in the present report, we aimed to investigate whether type 1 deiodinase (d1) sexual dimorphism exists early in sexual development by studying pre-pubertal male (pm) and female (pf) rats, as well as adult controls (c) and gonadectomized male and females rats. adult male wistar rats were studied 21 days after orchiectomy (tex), and adult females ... | 2007 | 17210749 |
| proteomic profiling of cold thyroid nodules. | cold thyroid nodules (ctns) represent a frequent endocrine disorder accounting for up to 85% of thyroid nodules in a population living in an iodine-deficient area. benign ctns need to be distinguished from thyroid cancer, which is relatively rare. the molecular etiology of benign ctns is unresolved. to obtain novel insights into their pathogenesis, protein expression profiling was performed in a series of 27 solitary ctns (10 follicular adenoma and 20 adenomatous nodules) and surrounding normal ... | 2007 | 17194741 |
| multicenter phase ii trial of chemoradiation with oxaliplatin for rectal cancer. | to evaluate the activity and safety of preoperative radiotherapy (rt) and concurrent capecitabine and oxaliplatin (xelox-rt) plus four cycles of adjuvant xelox in patients with rectal cancer. | 2007 | 17194912 |
| angiotensin type 1 (at1) and type 2 (at2) receptors mediate the increase in tgf-beta1 in thyroid hormone-induced cardiac hypertrophy. | increased thyroid hormone (th) levels are known to induce cardiac hypertrophy. some studies have provided evidence for a functional link between angiotensin ii (ang ii) and transforming growth factor beta1 (tgf-beta1) in the heart, both being able to also induce cardiac hypertrophy. however, the contribution of this growth factor activated directly by th or indirectly by ang ii in cardiac hypertrophy development remains unknown. to analyze the possible role of tgf-beta1 in cardiac hypertrophy in ... | 2007 | 17206447 |
| neoadjuvant therapy before radical prostatectomy: where have we been? where are we going? | prostate cancer is curable only when treated at an early stage, when the tumor is still localized to the prostate gland. however, even in apparent cases of clinically localized disease, unsuspected extracapsular disease may significantly increase the risk of primary treatment failure. this risk is especially high if the patient has > or =1 of the following risk factors: a serum prostate-specific antigen level of >20 ng/ml, a gleason score of >7, locally advanced disease (clinical stage t3/t4), a ... | 2007 | 17208133 |
| supra dietary levels of vitamins c and e enhance antibody production and immune memory in juvenile milkfish, chanos chanos (forsskal) to formalin-killed vibrio vulnificus. | juveniles of milkfish, chanos chanos (forsskal), were fed two independent supra dietary levels of vitamins c (500 and 1500 mg kg(-1) feed, t1 and t2) and e (50 and 150 mg kg(-1), t3 and t4). milkfish fed diets with supra (in addition to the vitamins present in the control diet) and normal levels (t5 containing 90 and 1.2mg of vitamins c and e, respectively, kg(-1) of feed) of vitamins were immunized (ip) with formalin-killed vibrio vulnificus (fkvv). priming and booster antibody responses to the ... | 2007 | 17208456 |
| phase i/ii study of preoperative cetuximab, capecitabine, and external beam radiotherapy in patients with rectal cancer. | to assess the safety and preliminary efficacy of concurrent radiotherapy, capecitabine, and cetuximab in the preoperative treatment of patients with rectal cancer. | 2007 | 17208931 |
| dynamics of lysozyme structure network: probing the process of unfolding. | recently we showed that the three-dimensional structure of proteins can be investigated from a network perspective, where the amino acid residues represent the nodes in the network and the noncovalent interactions between them are considered for the edge formation. in this study, the dynamical behavior of such networks is examined by considering the example of t4 lysozyme. the equilibrium dynamics and the process of unfolding are followed by simulating the protein at 300 k and at higher temperat ... | 2007 | 17208969 |
| approach to the patient with subclinical hyperthyroidism. | endogenous subclinical hyperthyroidism, defined by normal circulating levels of free t4 and t3 and low levels of tsh, is a common clinical entity and is typically caused by the same conditions that account for the majority of cases of overt hyperthyroidism: graves' disease, toxic multinodular goiter, and solitary autonomously functioning thyroid nodules. subclinical hyperthyroidism has been associated with an increased risk of atrial fibrillation and mortality, decreased bone mineral density in ... | 2007 | 17209221 |
| zosteriform skin involvement of nodal t-cell lymphoma: a review of the published work of cutaneous malignancies mimicking herpes zoster. | a 77-year-old japanese woman initially presented with non-hodgkin's lymphoma involving her neck, axillary and inguen lymph nodes. she had edematous erythema and nodules limited to the skin in zosteriform distribution on the left side chest wall along the t4-5 dermatome. in addition, since 1970, we have mainly been collecting english-language articles on malignant skin tumors and skin metastasis described as zosteriform in the title, and we have reviewed a total of 29 cases, including our own. it ... | 2007 | 17204106 |
| factors associated with poor general health after stem-cell transplantation. | to describe functional status (fs), general health (gh) and symptom distress (sd) from admission to 1 year post-sct and to identify medical, demographic, and/or patient-reported outcome variables associated with patient-perceived gh. | 2007 | 17205276 |
| timing of resection of liver metastases synchronous to colorectal tumor: proposal of prognosis-based decisional model. | timing of hepatectomy for synchronous metastases of colorectal cancer is still debated. the aim of this retrospective study was to analyze prognostic factors after synchronous and delayed liver resections to define selection criteria for choosing timing of hepatectomy. | 2007 | 17200913 |
| effects of evening vs morning thyroxine ingestion on serum thyroid hormone profiles in hypothyroid patients. | standard drug information resources recommend that l-thyroxine be taken half an hour before breakfast on an empty stomach, to prevent interference of its intestinal uptake by food or medication. we observed cases in which tsh levels improved markedly after changing the administration time of l-thyroxine to the late evening. we therefore conducted a pilot-study to investigate whether l-thyroxine administration at bedtime improves tsh and thyroid hormones, and whether the circadian rhythm of tsh r ... | 2007 | 17201800 |
| unmasking of central hypothyroidism following growth hormone replacement in adult hypopituitary patients. | the effect of gh replacement on thyroid function in hypopituitary patients has hitherto been studied in small groups of children and adults with conflicting results. | 2007 | 17201804 |
| expression analysis of pancreatic cancer cell lines reveals association of enhanced gene transcription and genomic amplifications at the 8q22.1 and 8q24.22 loci. | despite tremendous effort and progress in the diagnostics of pancreatic cancer with respect to imaging techniques and molecular genetics, only very few patients can be cured by surgery leading to a 5-year survival rate of only 3%. especially the lack of chemotherapeutical options in this entity requires a better understanding of the molecular mechanisms leading to pancreatic carcinoma growth and progression in order to develop novel treatment regimens. to identify signaling pathways that are cri ... | 2007 | 17203180 |
| differential dependence on dna ligase of type ii restriction enzymes: a practical way toward ligase-free dna automaton. | dna computing study is a new paradigm in computer science and biological computing fields. as one of dna computing approaches, dna automaton is composed of the hardware, input dna molecule and state transition molecules. by now restriction enzymes are key hardware for dna computing automaton. it has been found that dna computing efficiency may be independent on dna ligases when type iis restriction enzymes like foki are used as hardware. in this study, we compared foki with four other distinct e ... | 2007 | 17196173 |
| effects of larval-juvenile treatment with perchlorate and co-treatment with thyroxine on zebrafish sex ratios. | the objective of this study was to determine the effect of larval-juvenile exposure to perchlorate, a thyroid hormone synthesis inhibitor, on the establishment of gonadal sex ratios in zebrafish. zebrafish were exposed to untreated water or water containing perchlorate at 100 or 250 ppm for a period of 30 days starting at 3 days postfertilization (dpf). recovery treatments consisted of a combination of perchlorate and exogenous thyroxine (t4; 10 nm). thyroid histology was assessed at the end of ... | 2007 | 17196199 |
| cns hypomyelination in rat terrier dogs with congenital goiter and a mutation in the thyroid peroxidase gene. | arrested physical development and neurologic abnormalities were identified in 3 of 5 rat terrier puppies at 9 weeks of age. bilaterally firm symmetrical masses were palpated in the region of the thyroid glands. low serum total (t4) and free thyroxine (ft4, by equilibrium dialysis) and markedly elevated thyroid stimulating hormone (tsh) concentrations supported the diagnosis of hypothyroidism. at necropsy, the thyroid gland was grossly enlarged and histologically exhibited severe, diffuse hyperpl ... | 2007 | 17197623 |
| a prospective pathologic analysis using whole-mount sections of rectal cancer following preoperative combined modality therapy: implications for sphincter preservation. | the aims of this study were to use a comprehensive whole-mount pathologic analysis to characterize microscopic patterns of residual disease, as well as circumferential and distal resection margins, in rectal cancer treated with preoperative cmt; and to identify clinicopathologic factors associated with residual disease. | 2007 | 17197970 |
| simulation of dna electrophoresis through microstructures. | the dependence of the mobility of dna molecules through an hexagonal array of micropillars on their length and the applied electric field was investigated and it was found that mobility is a nonmonotonic function of their length. results also revealed that the size dependence of the dna mobility depends on the applied electric field and there is a crossover around e approximately 25 v/cm for the mobility of lambda-dna and t4-dna. these observations are explained in terms of the diffusion process ... | 2007 | 17191278 |
| differing effects of t4 dna ligase in the modulation of the damage induced in mammalian cells by either x-rays or restriction endonucleases. | of the different lesions induced by x-rays, dna double-strand breaks (dsbs) are considered the main cause of chromosomal aberrations and cell death. restriction endonucleases (res) induce only dna dsbs and have frequently been used to mimic the effects of ionizing radiation in the study of dna damage and repair. | 2007 | 17192708 |
| effect of a hypoglycemic agent on ischemic preconditioning in patients with type 2 diabetes and stable angina pectoris. | ischemic preconditioning is an increased tolerance to myocardial ischemia during the second of two consecutive exercise tests. atp-sensitive k(+) channel blockers, such as glinides and sulfonylurea drugs, can induce loss of ischemic preconditioning. this study aimed to investigate the effects of repaglinide, a hypoglycemic agent with an affinity for myocardial atp-sensitive k (+)channels, on the results of consecutive exercise tests in patients with diabetes and multivessel coronary artery disea ... | 2007 | 17172931 |
| effect of selenium supplementation on biochemical markers and outcome in critically ill patients. | this study aimed to assess the effect of high dose selenium (se) supplementation on se status in blood, oxidative stress, thyroid function and possible effects on requirement for renal replacement therapy (rrt) in severely septic patients admitted to the intensive care unit (icu). | 2007 | 17174015 |
| prognostic groups in 1,676 patients with t3 rectal cancer treated without preoperative radiotherapy. | the use of preoperative radiotherapy in patients with t3 tumors shows considerable variation among countries and institutions. the norwegian guidelines have been very restrictive, limiting the indication to t4. this study was designed to identify subgroups of patients with t3 tumors with presumed high risks on adverse outcome and to use these results to reevaluate the national guidelines for preoperative radiotherapy. | 2007 | 17180256 |
| short-term outcome after laparoscopic or open restorative mesorectal excision for rectal cancer: a comparative cohort study. | the laparoscopic approach to rectal cancer is still a controversial procedure. a comparative cohort study was conducted to assess short-term results of laparoscopic restorative mesorectal excision. | 2007 | 17180257 |
| analysis of anatomic morphometry of the pedicles and the safe zone for through-pedicle procedures in the thoracic and lumbar spine. | posterior instrumentation through the pedicle is a common surgery. understanding the morphometry of the pedicle and the anatomy of adjacent neural structures should help decrease the risk of postoperative complications. t1-l5 segments from 15 sets of human vertebrae were separated into individual vertebrae and the morphometric characteristics of the thoracic and lumbar spine and the safe zone of the pedicle were analyzed. t11-l5 segments from six human cadavers were dissected. measurements were ... | 2007 | 17180401 |
| a type iv modification dependent restriction nuclease that targets glucosylated hydroxymethyl cytosine modified dnas. | the escherichia coli ct596 prophage exclusion genes gmrs and gmrd were found to encode a novel type iv modification-dependent restriction nuclease that targets and digests glucosylated (glc)-hydroxymethylcytosine (hmc) dnas. the protein products gmrs (36 kda) and gmrd (27 kda) were purified and found to be inactive separately, but together degraded several different glc-hmc modified dnas (t4, t2 and t6). the gmr enzyme is able to degrade both alpha-glucosy-hmc t4 dna and beta-glucosyl-hmc t4 dna ... | 2007 | 17188297 |
| exclusion of glucosyl-hydroxymethylcytosine dna containing bacteriophages is overcome by the injected protein inhibitor ipi*. | the escherichia coli isolate ct596 excludes infection by the myoviridae t4 ip1(-) phage that lacks the encapsidated ipi* protein normally injected into the host with the phage dna. screening of a ct596 genomic library identified adjacent genes responsible for this exclusion, gmrs (942 bp) and gmrd (708 bp) that are encoded by a cryptic prophage dna. the two genes are necessary and sufficient to confer upon a host the ability to exclude infection by t4 ip1(-) phage and other glucosyl-hydroxymethy ... | 2007 | 17188711 |
| hydrolytic cleavage of dna by quercetin zinc(ii) complex. | quercetin zinc(ii) complex was investigated focusing on its hydrolytic activity toward dna. the complex successfully promotes the cleavage of plasmid dna, producing single and double dna strand breaks. the amount of conversion of supercoiled form (sc) of plasmid to the nicked circular form (nc) depends on the concentration of the complex as well as the duration of incubation of the complex with dna. the rate of conversion of sc to nc is 1.68x10(-4) s(-1) at ph 7.2 in the presence of 100 microm o ... | 2007 | 17189687 |
| prostate cancer progression in the presence of undetectable or low serum prostate-specific antigen level. | the serum prostate-specific antigen (psa) level after definitive treatment for prostate cancer (pc) is a powerful predictor of outcome. occasionally, pc progression can occur despite low or undetectable psa levels. the authors report on the clinical and pathologic characteristics of patients who experienced pc progression with undetectable or low psa levels. | 2007 | 17171704 |
| comparison between remnant and red-marrow absorbed dose in thyroid cancer patients submitted to 131i ablative therapy after rh-tsh stimulation versus hypothyroidism induced by l-thyroxine withdrawal. | in thyroidectomized patients, increased levels of thyroid stimulating hormone (tsh) are necessary to maximize i uptake. traditionally, this has been achieved by withdrawing l-thyroxine (l-t4) for 4-6 weeks, inducing hypothyroidism in patients. the availability of a genetically engineered version of the recombinant human tsh (rh-tsh) provides an alternative tool to enhance the tsh serum level without inducing hypothyroidism. in this paper the i remnant and red-marrow doses calculated in different ... | 2007 | 17264781 |
| ultrastructural observations on the elusive subtegumental cells of the viviparous gill monogenean, macrogyrodactylus clarii. | the ultrastructure of the tegument, including putative subtegumental cells, of the monogenean gill parasite macrogyrodactylus clarii is described for the first time. the lateral cells are secretory in nature and can be classified into four types: t1 producing elongated, electron-dense, bodies (t1); t2 manufacturing electron-lucent vesicles (t2); t3 producing thin, dump-bell shaped, electron-dense bodies (t3); and t4 containing lyzosome-like inclusions. morphologically, the t2 cells resemble thos ... | 2007 | 17265090 |
| nuclear localization of protein kinase ck2 catalytic subunit (ck2alpha) is associated with poor prognostic factors in human prostate cancer. | many genomic abnormalities have been identified in various subsets of prostate cancer, but until now, few genes have been associated with the progression of this cancer. high activity of protein serine/threonine kinase ck2 has been observed in various solid tumours and this alteration has been linked both to growth-related functions and to suppression of cellular apoptosis. here, we provide the first evidence for a strong association between a nuclear localization of ck2alpha, evaluated by immun ... | 2007 | 17267203 |
| design and numerical simulation of a dna electrophoretic stretching device. | dna stretching is now a key technology in emerging dna mapping devices such as direct linear analysis (dla), though dna stretching in a high throughput manner is still a challenging problem. in this work, we present a new microfluidic channel design to enhance dna stretching using kinematic analysis and brownian dynamics-finite element method (bd-fem). our group recently showed in experiments that the extensional electrophoretic field arising from a hyperbolic microcontraction can be utilized to ... | 2007 | 17268624 |
| cell-free co-synthesis of protein nanoassemblies: tubes, rings, and doughnuts. | we used a cell-free transcription/translation system to synthesize structural proteins of the t4 bacteriophage. we focused on two proteins that participate in the formation of the virus tail tube assembly. synthesized separately, the proteins assembled into their in vivo forms, namely one polymerized into rigid hollow nanotubes approximately 20 nm thick and hundreds of nanometers long, the other assembled into 10 nm tube-capping hexameric rings. co-synthesis of the two proteins, however, reveale ... | 2007 | 17269832 |
| the clinical utility of lens culinaris agglutinin-reactive thyroglobulin ratio in serum for distinguishing benign from malignant conditions of the thyroid. | traditionally, the follow-up of differentiated thyroid carcinoma consists of periodic withdrawal from l-t4-suppressive therapy to allow performance of a highly sensitive serum tg measurement to detect recurrences. we investigated lens culinaris agglutinin-reactive thyroglobulin ratios in serum to evaluate in usefulness for detection of thyroid carcinoma. | 2007 | 17270168 |
| kinematic analysis of the 100-m wheelchair race. | the purpose of this study was to compare the speed and selected stroke cycle characteristics during different phases of the 100-m wheelchair race for paraplegic athletes. four male and two female wheelchair racers in t4 classification and one male and three female athletes in t3 classification served as the participants. two s-vhs camcorders (60 fields/s) were panned horizontally to cover the first and second 50 m of the 100-m race, respectively. average speed, stroke length and frequency, conta ... | 2007 | 17270191 |
| us diagnosis of cervical recurrence in patients operated on thyroid cancer: sonographic features and clinical significance. | to describe the sonographic features of cervical recurrence in patient with thyroid cancer and review clinical significance. | 2007 | 17270376 |
| nutrient supplementation post ambulation in persons with incomplete spinal cord injuries: a randomized, double-blinded, placebo-controlled case series. | to examine effects of protein-carbohydrate intake on ambulation performance in persons with incomplete spinal cord injury (sci). | 2007 | 17270521 |
| large-scale study of clinical impact of psa velocity: long-term psa kinetics as method of differentiating men with from those without prostate cancer. | to assess the longitudinal prostate-specific antigen (psa) changes in a screening population with or without prostate cancer during a 10-year period. | 2007 | 17270635 |