Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| purification and characterization of human lysosomes from eb-virus transformed lymphoblasts. | 1981 | 6258947 | |
| seroepidemiological study of relationships between epstein-barr virus and rheumatoid arthritis. | to elucidate the relationship between epstein-barr virus (ebv) and rheumatoid arthritis (ra), we measured antibodies to ra-associated nuclear antigen (anti-rana) and three other ebv-related antigens in the sera of ra patients and controls. our study groups consisted of 89 patients with definite or classical ra, mean age 56, male/female ratio 47:42; and 53 normal and osteoarthritis controls, mean age 51, male/female ratio 25:28. in addition to anti-rana, we measured antibodies to viral capsid ant ... | 1981 | 6259207 |
| elevated levels of antibodies to epstein-barr virus antigens in sera and synovial fluids of patients with rheumatoid arthritis. | the frequencies and levels of antibodies to epstein-barr virus (ebv)-specific antigens were determined in paired sera and synovial fluids from patients with rheumatoid arthritis (ra) and in sera from patients with other connective tissue diseases; i.e., systemic lupus erythematosus, progressive systemic sclerosis, and osteoarthritis (oa). the specimens were also tested for the presence of antibodies to ra-associated nuclear antigen. compared to healthy controls, the patients' sera showed increas ... | 1981 | 6259211 |
| [epstein-barr virus in the environment of patients with hodgkin's disease]. | 1981 | 6258815 | |
| [effect of age and sex on antibody formation]. | 1981 | 6258817 | |
| herpes encephalitis after infectious mononucleosis. | 1981 | 6258252 | |
| epstein-barr virus-induced polypeptides: a comparative study with superinfected raji, iudr-treated, and n-butyrate-treated p3hr-1 cells. | 1981 | 6258314 | |
| primary epstein-barr virus infection in early childhood. | in a prospective study 43 consecutive children in hospital, aged between 6 months and 7 years and displaying at least one of the clinical signs of infectious mononucleosis (im), were investigated for epstein-barr (eb) virus-specific igm antibodies by an indirect immunofluorescence test. on this basis eb virus infection was considered confirmed in 8 patients, each of whom had igm antibodies in the initial serum sample. in one additional patient, igm antibodies were only detected in a second sampl ... | 1981 | 6258487 |
| fisher's syndrome associated with epstein-barr virus. | 1981 | 6258542 | |
| relative lack of epstein barr virus (ebv) receptors on b cells from persistently ebv seronegative adults. | viral receptors are essential for the entry of the virus into the cell. ebv receptors can be detected on fresh lymphocytes by a technique that uses ebv-coupled tanned red blood cells that form rosettes with lymphocyte-bearing receptors. this technique was found to detect viral receptors only and not surface immunoglobulins. t cell depletion of the lymphocyte population showed that these receptors were present on b lymphocytes. study of the presence of these ebv receptors on the surface of fresh ... | 1981 | 6257786 |
| age-associated changes in epstein-barr virus-induced human lymphocyte autoantibody responses. | in the present investigation we have studied the capacity of the epstein-barr virus (ebv), a ubiquitous human b lymphocyte polyclonal activator, to induce cultured peripheral blood lymphocytes from umbilical cords, young adults (20 to 40 yr old), and elderly adults (75 to 90 yr old) to form igm antibodies to human igg or human thyroglobulin. the ebv preparation used was shown to exert its b cell stimulatory effect independently of t cell-suppressor effects. the cultures were studied in limiting ... | 1981 | 6257787 |
| fatal epstein-barr virus-associated hemophagocytic syndrome. | 1981 | 6257876 | |
| thymidine and hypoxanthine requirements of normal and malignant human cells for protection against methotrexate cytotoxicity. | 1981 | 6257387 | |
| development of suppressor t lymphocytes for epstein-barr virus-induced b-lymphocyte outgrowth during acute infectious mononucleosis: assessment by two quantitative systems. | a system of 3h-thymidine incorporation by lymphocytes in culture for 3 wk has been utilized for quantitative assessment of the ability of t lymphocytes to inhibit outgrowth of autologous epstein-barr virus (ebv) transformed b lymphocytes. lymphocytes from ebv-seronegative individuals lack the ability to suppress outgrowth of autologous ebv-transformed b lymphocytes. this capability appears during the course of primary ebv-induced infectious mononucleases (im) as the atypical lymphocytosis is sub ... | 1981 | 6257313 |
| epstein-barr-virus-carrying lymphoma in a patient with ataxia-telangiectasia. | an undifferentiated lymphocytic lymphoma of mesenteric lymph nodes occurred in a young boy with ataxia-telangiectasia. two independent tests, epstein-barr virus (ebv)-crna/dna hybridisation and ebv dna/dna reassociation kinetic analysis, showed 53 and 68 ebv genome equivalents per cell respectively, which was compatible with an ebv-genome-carrying tumour. whether this was a polyclonal lymphoproliferation or a monoclonal tumour could not be determined owing to lack of suitable material. the prese ... | 1981 | 6257325 |
| hairy cell leukemia: establishment of a cell line and its characteristics. | a hairy cell leukemia (hcl) line, zk-h, was established from peripheral blood of a 69-year-old male patient. the zk-h cells and the patient's original hairy cells shared the same surface properties; both possessed membrane-bound igg with kappa light chains and villous surface structures. the zk-h line carried epstein-barr virus (ebv)-determined nuclear antigen, but the patient's fresh leukemic cells lacked this antigen. morphologically, the zk-h cells appeared lymphoblastoid and more primitive t ... | 1981 | 6257373 |
| epstein-barr virus infections in a nursery. | tests for epstein-barr virus (ebv) capsid antibody were carried out on 115 children, aged 4-32 months, on admission to and discharge from the junior village nursery, washington, d.c. forty-three children positive on admission remained positive at discharge, 44/72 negative on admission remained negative at discharge, and 28/72 negative on admission converted to positive at discharge. age, sex and season did not appear to influence the rate of ebv seroconversion among the nursery children. the onl ... | 1981 | 6257109 |
| cyclosporin a promotes spontaneous outgrowth in vitro of epstein-barr virus-induced b-cell lines. | cyclosporin a (csa) is a fungal metabolite which exerts profound effects on the immune system and has potential as a selective immuno-suppressive agent. clinical trials with human renal allograft recipients have confirmed this potential but there have been disturbing reports of lymphoma in a significant number of patients. despite extensive animal studies, the specificity of this drug for human lymphocyte subpopulations is largely unknown. we demonstrate here that in vitro csa has no apparent ef ... | 1981 | 6256660 |
| cell-surface immunoglobulin and insulin receptor expression in an ebv-negative lymphoma cell line and its ebv-converted sublines. | membrane ig and insulin receptors were assayed in the ebv-negative ramos lymphoma line and its ebv-converted sublines by surface fluorescence. 125i-protein a-binding assay, immunoprecipitation, and insulin receptor assay. the original ramos line expressed surface igm but not igd and had a low concentration of insulin receptors. ten of 10 converted lines expressed igd and a variable but usually high insulin-binding capacity. molecular weight analysis of immunoprecipitated ig showed the presence o ... | 1981 | 6256436 |
| human b cell activation in vitro: augmentation and suppression by monocytes of the immunoglobulin production induced by various b cell stimulants. | 1981 | 6256442 | |
| fulminant hepatic failure in childhood. | 1981 | 6256033 | |
| the transformation of adult but not newborn human lymphocytes by epstein barr virus and phytohemagglutinin is inhibited by interferon: the early suppression by t cells of epstein barr infection is mediated by interferon. | in a previous study, it was demonstrated that t cells from adult individuals were able to suppress the transformation of b cells after infection by ebv. in this paper, it is shown that this suppression is mediated by interferon. thus, the suppression is abrogated by anti-interferon serum and mimicked by human leukocyte interferon. furthermore, the interferon is released in response to the virus-infected b cell, not the virus alone. the relevance of these results to previous clinical evidence, in ... | 1981 | 6161964 |
| cytolytic human t-cell clones expressing epstein-barr virus specificity and hla restriction. | 1981 | 6173309 | |
| childhood social environment and hodgkin's disease. | the epidemiologic similarities between hodgkin's disease in the young and paralytic poliomyelitis suggest that hodgkin's disease may be a rare consequence of a common infection, with the probability of oncogenesis increasing with age at the time of infection. in a study of 225 cases and 447 controls 15 to 39 years of age, we investigated the association of hodgkin's disease with factors in childhood that influence age of exposure to infectious agents. risk among persons with five or more sibling ... | 1981 | 6255329 |
| in search of hodgkin's disease virus. | 1981 | 6255330 | |
| in vitro induction of hla-restricted cytotoxic t lymphocytes against autologous epstein-barr virus transformed b lymphoblastoid cell line. | cytotoxic t lymphocytes (ctl) against autologous ebv-transformed b lymphoblastoid cell line (lcl) were induced in vitro by culturing peripheral blood lymphocytes (pbl) of healthy donors together with mitomycin c-treated autologous lcl for 6 days. the cytotoxic cells developed only from the e-rosette-positive fraction but not from the negative fraction of pbl. these ctl killed autologous lcl but not pwm-stimulated autologous pbl. in addition, the ctl killed allogeneic lcl when at least 1 of the h ... | 1981 | 6163815 |
| t lymphocyte-mediated cytotoxicity against autologous ebv-genome-bearing b cells. | we have stimulated human peripheral blood lymphocytes in vitro with autologous ebv-infected or noninfected b cells. a cytotoxic response was obtained only when virally infected cells were used. the activity of the effector cells was restricted by the major histocompatibility complex and was directed against ebv-genome-bearing targets. the highest cytolytic response was obtained when lymphocytes of individuals previously exposed to the virus (ebv-vca positive) were used. lymphocytes of noninfecte ... | 1981 | 6163816 |
| epstein-barr virus rna. vi. viral rna in restringently and abortively infected raji cells. | nuclear and polyadenylated rna fractions of raji cells are encoded by larger fractions of epstein-barr virus dna (35 and 18%, respectively) than encode polyribosomal rna (10%). polyribosomal rna is encoded by dna mapping at 0.05 x 10(8) to 0.29 x 10(8), 0.63 x 10(8) to 0.66 x 10(8), and 1.10 x 10(8) to 0.03 x 10(8) daltons. an abundant, small (160-base), non-polyadenylated rna encoded by ecori fragment j (0.05 x 10(8) to 0.07 x 10(8) daltons) is also present in the cytoplasm of raji cells. after ... | 1981 | 6165836 |
| epstein-barr virus and herpesvirus saimiri: sensitivity to interferons and interferon inducers. | the in vitro sensitivity of oncogenic herpesviruses, epstein-barr virus (ebv), and herpesvirus saimiri (hvs) to human interferon produced by normal human leukocytes (le), lymphoblastoid cell lines (lyi), and diploid fibroblasts (fi) was studied. four virus strains were used: hvs s295c, the highly oncogenic hvs s396-o, the transforming b95-8 strain of ebv, and the nontransforming p3hr1 strain of ebv. all interferons were active when applied to the cells after absorption of hvs and p3hr1-ebv, alth ... | 1981 | 6165852 |
| induction of several new antigens, including a t cell-associated antigen, following conversion of the ebv-negative b cell line ramos to ehrb-ramos by epstein-barr virus. | 1981 | 6166685 | |
| human lupus inclusions and interferon. | raji cells, a human b lymphoblastoid cell line of burkitt lymphoma origin, formed lupus inclusions when grown in a medium conditioned by the growth of raji cells whose dna thymidine residues had been unifilarly (single-strandedly) substituted with bromodeoxyuridine. ultracentrifugation of this medium in excess of that required to remove epstein-barr virus and all other known mammalian viruses did not prevent the formation of the inclusions, and treatment of the conditioned medium with pronase de ... | 1981 | 6166984 |
| antigenic differences between the membrane antigen polypeptides determined by different eb virus isolates. | the antigenic specificities of the membrane antigen (ma) complex of three epstein-barr (eb) virus-producing cell lines have been compared by complete absorption of an anti-ma antiserum with p3hr-1 cells, followed by testing for residual anti-ma antibody activity against b95-8 and qimr-wil cells. indirect membrane immunofluorescence showed that the absorbed serum, which had lost the capacity to bind p3hr-1 cells, nevertheless gave bright staining on a small proportion of b95-8 cells. sds-polyacry ... | 1981 | 6167667 |
| epstein-barr virus and chromosomal defects: a family study. | 1981 | 6168880 | |
| interferon production by a human lymphoblastoid cell line (dg-75) free of the epstein-barr genome. | a new lymphoblastoid cell line, dg-75, was investigated for its ability to produce interferon. dg-75 cells, previously shown to be free of epstein-barr virus genome and receptors, could be grown in submerged culture and could produce interferon in titers comparable to interferon produced by namalva cells. the interferon produced was similar in size to the namalva interferon as determined by gel filtration in ultrogel aca54. the dg-75 cells present a new source of large quantities of interferon w ... | 1981 | 6169305 |
| iga antibody, antibody-dependent cellular cytotoxicity and prognosis in patients with nasopharyngeal carcinoma. | immunoglobulin fractions containing antibodies to the epstein-barr virus (ebv) were isolated from different sera and tested in the antibody-dependent cellular cytotoxicity (adcc) assay. all cytotoxic activity resided in the igg fraction. iga antibodies were not cytotoxic in this assay against cells expressing the ebv-induced membrane antigen complex. however, iga antibodies were able to block the igg-mediated adcc reaction, indicating that the iga and igg antibodies recognized the same evb-speci ... | 1981 | 6169655 |
| interferon production and activation of non-specific effector cells by stimulation with lymphoblastoid cell lines in vitro. | a population of non-specific effector lymphocytes is generated in response to stimulation with lymphoblastoid cell lines (lcl). these cytotoxic cells have an activity analogous to that exhibited by natural killer (nk) cells. when lymphoid cells lines established by transformation with epstein-barr virus (ebv) are used to stimulate autochthonous t-cell-enriched lymphocytes, the activity against the nk-sensitive target, k562, is increased up to 14-fold. the stimulated t lymphocytes produce interfe ... | 1981 | 6169656 |
| reactivation of epstein-barr virus-specific cytotoxic t cells by in vitro stimulation with the autologous lymphoblastoid cell line. | unfractionated mononuclear (um) cells and t cells freshly prepared from the blood of adult donors were co-cultivated in microtest plate wells with progressively lower numbers of cells from the autologous eb-virus-transformed b-cell line. the fresh cells present in co-cultures from eb virus antibody-negative (seronegative) donors regularly facilitated autologous cell line outgrowth, monitored after 4 weeks, whereas outgrowth was markedly inhibited in the corresponding co-cultures from seropositiv ... | 1981 | 6169663 |
| cytotoxic t cell recognition of epstein-barr virus-infected b cells. i. specificity and hla restriction of effector cells reactivated in vitro. | the experiments show that the phenomenon of regression, seen exclusively in epstein-barr (eb) virus-infected cultures of mononuclear cells from eb virus antibody-positive donors, is mediated by cytotoxic t cells reactivated in vitro and specifically recognizing an eb virus-induced lymphocyte-detected membrane antigen lydma. thus, effector t cells from regressing cultures kill autologous eb virus-transformed cells but not autologous pokeweed mitogen-stimulates lymphoblasts nor any of a range of e ... | 1981 | 6170517 |
| stimulation with autologous lymphoblastoid cell lines: lysis of epstein-barr virus-positive and -negative cell lines by two phenotypically distinguishable effector cell populations. | human lymphocytes, stimulated in vitro for 6 days with x-irradiated or glutaraldehyde-treated autologous epstein-barr (eb) virus-transformed lymphoblastoid cell lines (lcl), are cytotoxic for autologous and allogeneic eb+ lcls as well as for several eb- cell lines that are also susceptible to lysis by interferon-activated natural killer (nk) cells. to determine whether the apparent nonspecific lysis mediated by lcl-stimulated cells is due to a mixture of effector cells directed against different ... | 1981 | 6170690 |
| cellular immune defects to epstein-barr virus-determined antigens in young males. | three males with the x-linked lymphoproliferative syndrome (xlp) with hypo- or agammaglobulinemia following epstein-barr virus (ebv) infection and two males with the chronic mononucleosis syndrome were investigated for immune responses to ebv-determined antigens. males with xlp showed profound cellular immune defects. markedly diminished responses of natural killer cell and interferon-activated killer cell activities and impaired leukocyte migration inhibition responses to phytohemagglutinin wer ... | 1981 | 6171337 |
| the distribution of a specific hla-b27-associated cell surface component on the tissues of patients with ankylosing spondylitis. | in this paper, we report the presence on epstein-barr virus-transformed lymphoblastoid cell lines on platelets and on fibroblasts of an hla-b27-associated cell surface complex (antigenically related to some antigens of klebsiella k43 and k21) which is identical to or cross-reactive with the determinant present on the peripheral blood lymphocytes (pbl) of b27-positive patients with ankylosing spondylitis (as). by contrast, no klebsiella k43 markers could be demonstrated on the spermatozoa of b27+ ... | 1981 | 6171370 |
| natural cell-mediated immunity during viral infections. | 1981 | 6171387 | |
| lysis of human b-lymphocyte-derived lymphoma/leukemia cells of established cell lines by interferon-activated natural killer (nk) cells. | cultured cell lines derived from malignant epstein-barr virus (ebv)-negative b cells, and representative of the more common types of naturally occurring non-hodgkin lymphomas and related leukemias, were found to be sensitive to lysis by human natural killer (nk) cells. the observed lysis of such cell lines was mediated by a population of interferon-augmentable, fcr-positive, non-adherent lymphoid cells, which were also able to kill the "standard" nk targets k562 and molt-4. when the nk susceptib ... | 1981 | 6171529 |
| usages of interferon and interferon inducers in man: the second half of 1980. | 1981 | 6171689 | |
| core (2'-5')oligoadenylate and the cordycepin analog: inhibitors of epstein--barr virus-induced transformation of human lymphocytes in the absence of interferon. | the 3'-deoxyadenosine (cordycepin) analog of (2'-5')oligo(a) [(2'-5')oligoadenylate with a triphosphate at the 5' end], synthesized enzymatically from cordycepin 5'-triphosphate in lysed rabbit reticulocytes or l-cell extracts was (i) inhibitory to translation in lysed rabbit reticulocytes and (ii) metabolically stable in extracts of either l cells or c85-5c lymphoblasts. the 5' dephosphorylated (core) (2'-5')oligo(a) and the core cordycepin analog can replace human fibroblast interferon in prev ... | 1981 | 6171822 |
| conditions for cytomegalovirus stimulation of lymphocytes. | lymphocytes from healthy donors or from patients with chronic lymphocytic leukaemia were subjected to live or inactivated cytomegalovirus (cmv) or the mitogen phytohaemagglutinin. no early or late cmv antigens could be demonstrated in the lymphocytes, indicating that neither abortive nor replicative cmv infection takes place. only cells from cmv antibody-positive leukaemic and non-leukaemic donors were stimulated by cmv to dna synthesis, with a maximum on day 5. cells from all individuals respon ... | 1981 | 6171871 |
| beta 2-microglobulin serum levels in infectious mononucleosis in childhood. | a material of fifteen children aged 10 months to 15 years with infectious mononucleosis (im) was investigated. the diagnosis was established by demonstration of epstein-barr virus (ebv) specific igm antibodies. the serum concentrations of beta 2-microglobulin (beta 2-m) were significantly increased (p less than 0.01) in the first sample after onset of disease, compared to control groups of children with other infectious diseases and children without diseases. the serum concentration of beta 2-m ... | 1981 | 6171995 |
| activation of the epstein-barr virus genome by 5-aza-cytidine in latently infected human lymphoid lines. | recent studies indicate that gene expression in higher eukaryotes is accompanied by a decrease in the frequency of 5-methyl cytosine residues around the activated site (razin and riggs, 1980). 5-aza-cytidine (5-aza-c) is an analogue that reduces cytidine methylation in dna (jones and taylor, 1980) and has been reported to change the differentiation pattern of cultured mouse embryo cells (taylor and jones, 1979). we have tested its ability to activate the epstein-barr virus cycle in latently ebv- ... | 1981 | 6172387 |
| staphylococcal protein a enhances natural killing activity against lymphoid tumor cell lines. | protein a (pa), was found to augment the natural killing (nk) activity of peripheral blood lymphocytes against burkitt's lymphoma-derived raji and daudi cells. this pa-enhanced nk activity was determined using the 51chromium release microcytotoxicity assay. it was found that the increased nk activity was dependent on the concentration of pa used. in addition, the pa-enhanced nk activity was dependent on the time of incubation of pa with the effector and target cell mixture. pretreatment of effec ... | 1981 | 6172391 |
| epstein-barr virus strain- and group-specific antigenic determinants detected by monoclonal antibodies. | in order to differentiate epstein-barr virus (ebv) strains by serological markers we prepared hybridomas producing monoclonal antibodies against polypeptides of the qimr-wil ebv strain. these monoclonal antibodies were screened by indirect immunofluorescence techniques. immunoprecipitation using ebv-positive monoclonal antibodies and the protein a method, of 125i-labelled polypeptides from purified qimr-wil ebv particles, revealed that a series of monoclonal antibodies against the four main surf ... | 1981 | 6172392 |
| antigen-specific antibody response induced in cultures of human blood lymphocytes in presence of polyethylene glycol. | human peripheral blood lymphocytes respond in vitro to sheep red blood cells (srbc) with the appearance of numerous specific plaque-forming cells, if the epstein-barr virus (ebv) is added to the cultures together with the antigen. however, it was found that when polyethylene glycol (mol. wt. 6000) is included in the culture medium at a final concentration of 4%, antigen alone is able to induce an anti-srbc response, with clear hemolytic plaques of regular size. addition of ebv causes a further i ... | 1981 | 6173234 |
| [immunologic protection against epstein-barr virus induced oncogenesis: cooperative effect of lymphocytes, antibodies and interferon in healthy individuals (author's transl)]. | immunologic cytotoxicity against lymphocytes transformed or infected by epstein-barr virus (ebv) was mainly studied in an autologous in vitro system by 51cr release assay and ebv-determined nuclear antigen (ebv)-specific trypan blue exclusion method. the following results were obtained. 1. the ebv-transformed or ebv-infected lymphocytes were killed with high frequency, when they were incubated with autologous lymphocytes in the presence of ebv-positive autologous serum. exposure to lymphocytes a ... | 1981 | 6175556 |
| presence of epstein-barr virus dna in tonsillar tissues. | sera from 48 tonsillar carcinoma (tc) patients, 48 matched controls and 16 recurrent exudative tonsillitis (ret) patients were examined for the presence of epstein-barr virus (ebv) associated nuclear antigen (ebna), early antigen (ea) and virus capsid antigen (vca). higher prevalence and significantly higher antibody titres against all three ebv-associated antigens were observed in tc patients in comparison with controls and ret patients. patients suffering from anaplastic tc had higher titres o ... | 1981 | 6120637 |
| long-term t-cell-mediated immunity to epstein-barr virus in renal-allograft recipients receiving cyclosporin a. | peripheral-blood mononuclear cells from renal-allograft patients receiving cyclosporin a (csa) were tested for their ability to produce t cells cytotoxic for eb-virus-infected b-cell targets in culture and compared with those from healthy seropositive subjects. whereas in the control cultures the proliferating foci of eb-virus-transformed b cells regressed after 2 weeks, no such regression was seen in cultures from csa-treated patients. these results indicate that patients receiving csa cannot m ... | 1981 | 6109048 |
| what we could do with an ebv vaccine. | 1981 | 6110958 | |
| kawasaki disease and epstein-barr virus. | 1981 | 6112339 | |
| presence of elevated antibody titres to epstein-barr virus before hodgkin's disease. | sera taken 12 and 21 months before the diagnosis of hodgkin's disease in two patients showed higher antibody levels to several epstein-barr-virus (ebv) antigens than did sera from eight matched controls. in one case the titres of all eb antibodies except that to nuclear antigen were raised in a serum sample obtained 45 months after the diagnosis was made. antibody levels to herpes simplex, cytomegalovirus, and varicella zoster viruses were normal in both cases. a third patient with histiocytic l ... | 1981 | 6112530 |
| epstein-barr virus rna vii: size and direction of transcription of virus-specified cytoplasmic rnas in a transformed cell line. | at least three separate regions of the epstein-barr virus (ebv) genome encode rna in a cell line that is growth transformed and nonpermissively infected with ebv. six polyadenylylated cytoplasmic rnas have been identified from these three regions. an abundant rna 3.0-3.1 kilobases (kb) long is encoded by dna of the internal reiteration, ir, and dna that maps at 25.7-30 megadaltons. a second, abundant, 2.9-kb rna is primarily encoded by dna at 110-03 megadaltons but probably has a 3' end to the l ... | 1981 | 6112750 |
| is histiocytic medullary reticulosis a fatal form of infectious mononucleosis? | 1981 | 6113417 | |
| hodgkin's disease and epstein-barr virus. | 1981 | 6113478 | |
| malaria, sex, and place of residence as factors in antibody response to epstein-barr virus in ghana, west africa. | both epstein-barr virus and malaria have been implicated as possible factors in burkitt's lymphoma. to examine this implication a cross-sectional serological survey of an urban and a rural population in ghana was conducted. malaria was more prevalent in the rural areas, but there was no difference in antiviral capsid antigen (vca) antibody titres between urban and rural dwellers. there was also no correlation between anti-malaria antibody titres and anti-vca antibody titres. thus malaria does no ... | 1981 | 6113482 |
| treatment of childhood combined epstein-barr virus/cytomegalovirus infection with oral bovine transfer factor. | an illness lasting for two years, with recurrent fever, rash, abdominal pain, and arthralgia, developed in a four year old boy. he was found to have a combined epstein-barr virus and cytomegalovirus (cmv) infection. his symptoms, cmv in his urine, and an absent in vitro lymphocyte response to cmv antigen persisted for two years. after treatment with orally administered bovine transfer factor clinical symptoms and viruria disappeared and specific immunity to cmv developed. evaluation of this trea ... | 1981 | 6113484 |
| cyclosporin a immunosuppression and epstein-barr antibody. | 1981 | 6114256 | |
| ecto-adenosine triphosphatase deficiency in cultured human t and null leukemic lymphocytes. a biochemical basis for thymidine sensitivity. | cultured leukemic t and null lymphocytes are highly sensitive to growth inhibition by thymidine, as well as the other deoxynucleosides, deoxyguanosine and deoxyadenosine. by contrast, epstein-barr virus-transformed b lymphocytes are relatively resistant to deoxynucleosides. growth inhibition is associated with the development of high deoxyribotriphosphate pools after exposure to the respective deoxynucleotides. we show that malignant t and null lymphocytes are deficient in ecto-atpase activity. ... | 1981 | 6114965 |
| epstein-barr virus and hodgkin's disease. | 1981 | 6115129 | |
| effects of hydrocortisone on the synthesis of epstein-barr virus antigens in p3hr-1 cells. | hydrocortisone was capable of enhancing the synthesis of epstein-barr virus antigens in producer p3hr-1 cells which had been induced with a 24-hr pulse of 5-iodo-2-deoxy-uridine. the effect of hydrocortisone was time dependent, suggesting that an early step in the induction process, and not the antigen synthesis itself, was influenced by the drug. | 1981 | 6115566 |
| multiple sclerosis and epstein-barr virus. | 1981 | 6118702 | |
| abnormal responsiveness of rheumatoid b cells to epstein-barr virus infection in vitro. | 1981 | 6118742 | |
| lack of regression in epstein-barr virus infected leucocyte cultures of nasopharyngeal carcinoma patients. | 1981 | 6118752 | |
| human anti-tetanus toxoid monoclonal antibody secreted by ebv-transformed human b cells fused with murine myeloma. | an epstein-barr virus (ebv)-transformed human b cell line (b6) producing anti-tetanus toxoid (tt) antibody was fused with a nonimmunoglobulin (ig)-producing murine myeloma and selected in hypoxanthine-aminopterin-thymidine (hat) medium containing 10(-5) m ouabain. surviving cells were cloned by limiting dilution and confirmed as hybrids by karyotype analysis and g-11 staining. hybridomas were stable and secreted 10-fold more anti-tt antibody (igm kappa) than the human parental cell line. in addi ... | 1982 | 6092264 |
| prolonged atypical illness associated with serological evidence of persistent epstein-barr virus infection. | seven patients with prolonged atypical illness were followed up for more than a year. sera taken during that period showed significantly increased titres of igm antibodies against the viral capsid antigen (vca) of epstein-barr virus (ebv). in four of the patients antibodies to the r component of the early antigen (ea) complex of ebv were clearly detectable. only one of these seven patients had presented with symptoms of classic infectious mononucleosis. serological and clinical observations in t ... | 1982 | 6119490 |
| serum antibody profile against herpesviruses in renal transplant recipients. | forty-eight renal allograft recipients who had received a kidney graft 2 months to 8 years previously, were followed for the presence of serum antibody against cytomegalovirus (cmv), epstein-barr virus (ebv), herpes simplex virus (hsv), and varicella-zoster virus (vzv). these investigations were performed over a 6 months period and in at least two serum samples from each patient, obtained at intervals of 2-3 months. the presence of serological signs of recent or active infection were observed in ... | 1982 | 6100358 |
| two distinct human cloned t cell lines that exhibit natural killer-like and anti-human effector activities. | cloned t cell lines from mixed lymphocyte cultures stimulated with autologous epstein barr virus- (ebv) transformed lymphoblastoid cell line (lcl) cells were established using a limiting dilution technique in the presence of t cell growth factor (tcgf). the t cell lines included two distinct clones of cytotoxic t cells (tc) in addition to ebv-specific tc. a cytotoxic profile of one cloned line was similar to that of endogenous nk cells in peripheral blood. the other cloned tc line showed an anti ... | 1982 | 6120975 |
| increased (2'-5')-oligo-a synthetase activity in patients with prolonged illness associated with serological evidence of persistent epstein-barr virus infection. | 1982 | 6122038 | |
| epstein-barr-virus-specific t-cell memory in renal-allograft recipients under long-term immunosuppression. | the level of long-term responsiveness of cytotoxic t cells to epstein-barr (eb) virus has been measured in peripheral-blood mononuclear-cell cultures from symptom-free renal-allograft recipients under conventional immunosuppression. 8 of 22 patients showed a profoundly impaired responsiveness when compared with health control donors. the allograft recipients as a group showed raised antibody titres to eb-virus capsid and early antigens, but within the group there was no clear relation between th ... | 1982 | 6122768 |
| infectious mononucleosis and systemic lupus erythematosus. | 1982 | 6122807 | |
| evolution of infectious mononucleosis into epstein-barr virus carrying monoclonal malignant lymphoma. | a monoclonal malignant lymphoma was diagnosed in a 30-month-old japanese boy, who, since the age of 12 months, had had chronic, recurrent infectious mononucleosis manifested by repeated episodes of severe cough and high fever accompanied by marked lymphadenopathy and hepatosplenomegaly and high serum epstein-barr virus (ebv) antibody titres. the diagnosis of burkitt's lymphoma was made when a cervical lymph-node biopsy specimen revealed massive proliferation of immature b-cells with starry-sky h ... | 1982 | 6123020 |
| immunity to epstein-barr virus in cyclosporin a-treated renal allograft recipients. | 1982 | 6123746 | |
| epstein-barr-virus-carrying lymphoma in cardiac transplant recipient. | 1982 | 6123868 | |
| anti-human cytomegalovirus nuclear antigen antibodies of different immunoglobulin classes. | igg, igm and iga immunoglobulin classes of antibodies to human cytomegalovirus nuclear antigens (cmna) were studied by the acid-fixed nuclear binding technique (afnb) and combined anti-complement immunofluorescence (combined acif). in acute cases of infectious mononucleosis (im) of human cytomegalovirus (hcmv) origin and in the so-called double virus infections (hcmv + epstein-barr virus), anti-cmna igm antibodies were detected. they were absent from both anti-hcmv positive sera of healthy donor ... | 1982 | 6124112 |
| outbreak of burkitt's-like lymphoma in homosexual men. | four cases of burkitt's-like lymphoma (undifferentiated, monoclonal, b-cell tumours) in homosexual men were seen in a 9-month period in san francisco. one tumour contained both epstein-barr-virus nuclear antigen (ebna) and cytomegalovirus (cmv) antigen. another tumour contained ebna, and a third contained no viral antigen, but ebna and cmv antigens were detected in the overlying epithelium. this outbreak widens the array of neoplasms affecting immunosuppressed homosexual men and provides further ... | 1982 | 6125777 |
| rheumatoid lymphocyte defect revealed by cyclosporin a. | 1982 | 6126656 | |
| no indication of active epstein-barr virus infection in two fatal cases of histiocytic medullary reticulosis. | 1982 | 6126683 | |
| new clinical manifestations of epstein-barr virus infection. | 1982 | 6128552 | |
| defective rheumatoid lymphocyte function assessed by epstein-barr virus infection in vitro. | 1982 | 6128620 | |
| [liver diseases in children]. | 1982 | 6175880 | |
| stimulation of human lymphocytes with irradiated cells of the autologous epstein-barr virus-transformed cell line. i. virus-specific and nonspecific components of the cytotoxic response. | 1982 | 6176332 | |
| stimulation of human lymphocytes with irradiated cells of the autologous epstein-barr virus-transformed cell line. ii. cytotoxic response to repeated stimulation. | 1982 | 6176333 | |
| the increased natural killer sensitivity of epstein-barr virus (ebv)-superinfected raji cells is not due to the recognition of serologically determined ebv antigens by the effectors. | 1982 | 6176334 | |
| epstein-barr virus-specific cytotoxic t-cell clones restricted through a single hla antigen. | 1982 | 6176881 | |
| identification of epstein-barr virus strain differences with monoclonal antibody to a membrane glycoprotein. | two monoclonal antibodies directed against epstein--barr virus (ebv)-induced membrane antigens (ma) were isolated in this study. on of the monoclonal antibodies, designated 2f5.6, was an igg2 which, as detected by membrane and fixed cell immunofluorescence, reacted with ma-positive lymphoblastoid cell lines that produced transforming ebv but not with the ma-positive p3hr-1 cell line that produced the lytic, nontransforming strain of this virus. this antibody precipitated the mr 320,000/350,000 g ... | 1982 | 6176998 |
| antiviral effects of interferon on a somatic cell hybrid between two burkitt's lymphoma cell lines of different interferon sensitivities. | a somatic cell hybrid between two human burkitt's lymphoma cell lines, raji and daudi, was infected with either epstein-barr virus or vesicular stomatitis virus after interferon treatment. raji cells are resistant to the antiviral effects of exogenously added interferon, whereas daudi cells are interferon sensitive. the raji-daudi hybrid showed an interferon sensitivity that was intermediary to that of the parental cells against both viruses. | 1982 | 6177642 |
| production and characterization of monoclonal antibodies against the epstein-barr virus membrane antigen. | five murine hybridoma lines that produce monoclonal antibodies against epstein-barr virus membrane antigen (ma) were established. immunoprecipitation experiments demonstrated that three of the antibodies precipitated both the 236,000 (236k) ma and the 212k ma. the other two antibodies precipitated the 86k ma. antibodies against the 236k-212k ma and the 86k ma mediated complement-dependent cytolysis of epstein-barr-virus-infected cells. the antibodies against the 86k ma neutralized both the b95-8 ... | 1982 | 6177865 |
| interferon enhances the expression of epstein-barr virus early antigen in daudi cells. | treatment of the burkitt lymphoma-derived cell line daudi with highly purified human interferon-alpha (ifn-alpha) increased up to 100-fold the number of cells expressing epstein-barr virus (ebv)-determined early antigen (ea) without inducing the synthesis of virus capsid antigen (vca), a late virus function. the increase in the number of ea-positive cells was proportional to interferon concentration up to 10(4) international units (iu)/ml. treatment of daudi cells with the same number of units o ... | 1982 | 6178801 |
| elevation of serum beta 2-microglobulin levels during infectious mononucleosis. | 1982 | 6179672 | |
| lysis of autologous epstein-barr virus-infected b cells by cytotoxic t lymphocytes of rheumatoid arthritis patients. | 1982 | 6179673 | |
| a theory of virus-induced demyelination in the landry-guillain-barré syndrome. | the landry-guillain-barré syndrome (lgbs) is a demyelinating disorder of the peripheral nervous system frequently preceded by infection with common viruses. most prevalent among these agents are herpesviruses, particularly epstein-barr virus (ebv) and cytomegalovirus (cmv). the specific role played by antecedent viral infection in the pathogenesis of the lgbs remains obscure. in this regard, recent studies of marek's disease (md) neuropathy, an avian herpesvirus-induced experimental model for th ... | 1982 | 6180144 |
| epstein-barr virus rna. viii. viral rna in permissively infected b95-8 cells. | more than 50 rnas expressed by epstein-barr virus late in productive infection have been identified. b95-8-infected cells were induced to a relatively high level of permissive infection with the tumor promotor 12-o-tetradecanoylphorbol-13-acetate. polyadenylated rnas were extracted from the cell cytoplasm, separated by size on formaldehyde gels, transferred to nitrocellulose, and hybridized to labeled recombinant epstein-barr virus dna fragments. comparison of rnas from induced cultures with rna ... | 1982 | 6180174 |
| evidence for two classes of chromatin-associated epstein-barr virus-determined nuclear antigen. | a new class of epstein-barr virus nuclear antigen (ebna) was identified by the complement fixation assay. this new species of ebna is more tightly bound to chromatin and was termed class ii ebna, as opposed to the more weakly associated species, class i ebna. preparations of this new antigen(s) specifically reduced absorption with the titer of anti-ebna antibodies as determined by the anticomplement immunofluorescence assay. therefore, the complement fixation antigens (class ii ebna) appear to b ... | 1982 | 6180183 |
| enhancement of spontaneous vca and ea induction in b95-8 cells and ea induction in raji cells treated with human leukocyte interferon. | the purpose of this study was to determine the antiviral effect of human leukocyte interferon on epstein-barr virus (ebv) viral capsid antigen (vca) and early antigen (ea) induction in b95-8 and raji cells. interferon made at the institute of virology, beijing, and that provided by dr. cantell gave unexpected results. both interferon preparations markedly enhanced spontaneous vca and ea induction in b95-8 cells and ea induction in raji cells simultaneously treated with croton oil and n-butyrate. ... | 1982 | 6181009 |