Publications

hemophilus and pneumococcal peritonitis in children with the nephrotic syndrome.	two children are reported whose nephrotic syndrome was complicated by peritonitis due to h. influenzae type b. in pittsburgh, the leading organism for peritonitis in nephrosis remains d. pneumoniae with a disproportionately high incidence in black children. although h. influenzae is a rare cause of this complication, it should be considered along with the other previously recognized etiological bacterial agents.	1975	241048
immunoelectroosmophoresis (ieop) for detection of bacterial antigens in cerebrospinal fluid.	365 cerebrospinal fluid specimens from 259 patients were tested by the immunoelectroosmophoretic (ieop) method to detect bacterial antigens. 25 patients had bacterial meningitis. the bacterial agent was identified by ieop in 16 of 21 cases with aetiological agents detectable with the antisera employed. no false positive reactions occurred. the test gave true negative results in 340 instances. the rapidity, simplicity, sensitivity, reliability and low cost are emphasized.	1975	241117
erythromycin stearate in acute maxillary sinusitis.	76 patients with acute maxillary sinusitis were treated with oral erythromycin stearate (500 mg twice or 3 times a day for 10 days). the mean concentration of erythromycin in the sinus secretion after 3-5 days' treatment was 0.6 mug/ml with the lower dosage and 1.3 mug/ml with the higher. the concentration of erythromycin in the sinus secretion was, on the average, 10-20 times higher than the minimum inhibitory concentration (mic) for group a streptococci and pneumococci, and reached mic values ...	1975	241119
cephradine and cephalexin in the treatment of children with bacterial pneumonia.		1975	241608
bacterial meningitis. some aspects of diagnosis and treatment.		1975	242276
[some problems of purulent meningitides].		1975	764982
photoreactivation of template activity of uv-irradiated dna in an rna-polymerase system. a rapid assay for photoreactivating enzyme.		1975	803458
agglutinin response to bacterial infection in acute exacerbations of chronic bronchitis.	agglutinin titres to haemophilus influenzae, streptococcus pneumoniae, klebsiella pneumoniae, staphylococcus aureus, pseudomonas aeruginosa, escherichia coli, and proteus vulgaris in the serum of patients with acute exacerbations of chronic bronchitis, patients producing mucoid sputum, and healthy controls were determined. serological evidence of infection with h. influenzae was found in 38 of 57 patients with acute exacerbations, and str. pneumoniae infection in 10 of the 57 patients, but was g ...	1975	805163
n-nitrosocarbaryl-induced mutagenesis in haemophilus influenzae strains deficient in repair and recombination.	mutagenesis was studied in repair- and recombination-deficient strains of haemophilus influenzae after treatment with n-nitrosocarbaryl (nc). three different strains of h. influenzae carrying mutations affecting excision-repair of uv-induced pyrimidine dimers exhibited normal repair of premutational lesions (as detected by decreased mutation yield resulting from post-treatment dna synthesis delay) and normal nonreplicative mutation fixation. this indicated that neither of these phenomena are cau ...	1975	805362
biphasic reaction after inhalation of haemophilus influenzae in patients with chronic nonspecific lung disease.	in patients with chronic nonspecific lung disease (cnsld), who had precipitins against haemophilus influenzae (hi), a biphasic bronchial obstructive reaction is described after inhalation of killed hi bacteria. there was an early obstructive reaction, occurring immediately after the inhalation and lasting for 1 hr, followed by a late reaction, which started 5-6 hr after the inhalation and lasted for about 8 hr. the late reaction was accompanied by fever, malaise and leucocytosis. the difference ...	1975	806400
bacterial infections of the nervous system; etiologic and therapeutic aspects.		1975	806402
microbial development of drug resistance: mechanisms and clinical significance.	bacteria have demonstrated a disconcerting ability to develop resistance to antimicrobial agents nearly as quickly as new compounds become available. during the past two decades the molecular bases of several types of resistance have been elucidated. mechanisms of resistance include the transference of genetic material either through conjugation (involving direct contact between microorganisms), or indirectly through transduction (involving bacteriophages). in addition to this "infectious" drug ...	1975	806419
a study of the agglutinin response in 40 cases of bacterial pneumonia.	comparison of the results of cultures from blood and sputum with those of agglutinin response in 40 cases of bacterial pneumonia and 36 controls suggests that a provisional identification of causal bacteria, for purposes of antibiotic therapy, may be made by the serological tests with much greater rapidity and comparable accuracy. a combination of these methods is recommended.	1975	806611
mycoplasma pneumoniae infection followed by haemophilus influenzae pneumonia and bacteremia.	a 31-year-old, previously healthy woman contracted mycoplasma pneumoniae infection, proved by isolation and serologic titer rise. she was inadequately treated, and before complete recovery, she became ill with haemophilus influenzae pneumonia and bacteremia.	1975	807138
[tetracycline resistance in haemophilus influenzae is plasmid-linked].	a strain of haemophilus influenzae resistant to tetracycline (mic 16-32 mug/ml) was "cured" of tetracycline resistance by ethidium bromide. dna centrifugation in cesium chloride + ethidium bromide density gradients showed the existence of a band of non-chromosomal dna molecules in the original resistant strain. this band was not found in lysates of a strain "cured" of tetracycline resistance by ethidium bromide. these facts support the hypothesis that in this strain of haemohpilus influenzae, te ...	1975	807346
[bacteriological studies on fosfomycin. antibacterial activity in vitro and in vivo (author's transl)].	we have examined the antibacterial activity of the new antibiotic, fosfomycin (fom) in vitro and in vivo. the following results were obtained. 1. fom showed a broad antibacterial spectrum. 2. the antibacterial activity of fom was enhanced in the medium at ph 6 and ph 7, and was also influenced by the addition of rabbit serum, calf serum, glucose-6-phosphate or defibrilated sheep blood to the growth medium, and by the size of inoculum. 3 fom showed especially strong bactericidal action upon the b ...	1975	807758
investigation of the repetitive sequences in calf dna by cleavage with restriction nucleases.	calf thymus dna was digested with the restriction nucleases from escherichia coli carrying resistance transfer factor i, haemophilus influenzae rd and bacillus subtilis x5 (ecori, hind ii, and bsu, respectively) and submitted to polyacrylamide gel electrophoresis. about 10% of the dna migrated as discrete fragments in 8, 16, and 30 bands, respectively, superimposed upon a continuous distribution of various size dna fragments. the fragments within the bands are repeated 2000 to 160000 times in th ...	1975	809285
mapping of cleavage sites for restriction endonucleases in lambdadv plasmids.	restriction nucleases from escherichia coli carrying the resistance transfer factor ri, from hemophilus influenzae, hemophilus parainfluenzae, and bacillus subtilis were used for the generation of specific dna fragments from lambdadv plasmids. cleavage maps were established for various plasmids containing different but overlapping parts of bacteriophage lambdadna by analysis of digestion patterns obtained in polyacrylamide gel electrophoresis. the correlation between the plasmid cleavage maps an ...	1975	809288
inhibitory effect in vitro of sodium polyanethol sulfonate on the growth of neisseria meningitidis.	the influence of 0.05% sodium polyanethol sulfonate on the growth of 24 strains of neisseria meningitidis in broth medium was examined; several of the strains were markedly inhibited. a paper disk method was evolved for screening the sensitivity of various bacteria to sodium polyanethol sulfonate on solid medium; the highest sensitivity was observed in n. meningitidis and neisseria gonorrhoeae. zones of growth inhibition were also observed in a proportion of strains in certain species of gram-po ...	1975	809480
[nitrofurantoin-test for the differentiation of bordetella bronchiseptica (author's transl)].	bordetella bronchiseptica is primarily resistant against nitrofurantoin (mic greater than 200 mug/ml), and this feature can be used for the differentiation of the organism from other gram-negative coccobacteria. nitrofurantoin paper disks (300 mug) failed to affect the growth of 150 strains of b. bronchiseptica isolated from different animal hosts, but they produced marked inhibition zones in the cultures of the followingspecies: pasteurella multocida, pasteurella pneumotropica, pasteurella haem ...	1975	809944
[immunology of pulmonary diseases. (1) immunological studies of pathogenic factors in bacterial respiratory infections].		1975	813045
[experimental and clinical studies of talampicillin (pc-183)].		1975	815460
[investigations on mycoplasma attacks in patients with chronic bronchitis (author's transl)].	in 50 patients with chronic bronchitis, and additional attack by mycoplasma was found in at least 4 cases. this percentage corresponds approximately to the statements in the literature. in patients with mycoplasma in the sputum, radiologically signs of a bronchitis and peribronchitis were found which, for the short duration of the symptoms are unusual for a chronic bronchitis. purulent sputum was only observed after several days in the many relapses which ran a course similar to a virus infectio ...	1975	817129
[the nature of nuclear enlargement in urethane and isoprotenol-stimulated salivary glands (author's transl)].		1975	1073694
letter: haemophilus influenzae in the elderly.		1975	1078557
[value of agar gel precipitin test in the detection of haemophilus influenzae infection in chronic respiratory diseases].		1975	1078570
interdigitated repeated sequences in bovine satellite dna.		1975	1078604
american academy of pediatrics. committee on infectious diseases. ampicillin-resistant strains of hemophilus influenzae type b.		1975	1078610
ampicillin-resistant hemophilus influenzae type b: a status report.		1975	1078611
meningitis due to an unusual type of haemophilus influenzae.	an infant was admitted to hospital with suspected meningitis. haemophilus influenzae type 'a' was isolated from cerebrospinal fluid (c.s.f.) and blood. haemophilus meningitis due to types other than type 'b' is rare, and only a few due to type 'a' have so far been recorded. investigations of the family are included together with a discussion of the implications for the diagnostic bacteriologist.	1975	1078612
evolution of phi chi 174. ii. a cleavage map of the g4 phage genome and comparison with the cleavage map of phi chi 174.		1975	1078741
hemophilus parainfluenzae meningitis.	although hemophilus influenzae is a common cause of meningitis, other members of the hemophilus genus are rarely the infecting organism. of 56 cases of meningitis due to hemophilus species obseved at one hospital in the period 1970-74, 53 were due to h. influenzae and 3 to h. parainfluenzae. in the cases of h. parainfluenzae meningitis the clinical picture was complicated by associated sepsis, and therapy with ampicillin was not entirely satisfactory.	1975	1078783
ampicillin in haemophilus influenzae meningitis. clinicopharmacologic evaluation of intramuscular vs intravenous administration.	sixty-two children with haemophilus meningitis were treated with ampicillin sodium, 200 mg/kg/day for ten days. thirty-one received the drug intravenously (iv) for ten days; the other 31 patients received ampicillin iv for five days (except for one test dose given intramuscularly [im] on day 2) followed by im administration of ampicillin the last five days. ampicillin concentrations in cerebrospinal fluid (scf) were higher one hour after iv administration, but at two and four hours, concentratio ...	1975	1078934
[obtaining specific non-adsorbed sera to haemophilus influenza for the agglutination test on glass].	type-specific agglutinating sera to capsular antigenas of h. influenzae were recovered (from 1:3200 to 1:25600). with the given immunization scheme there formed mostly igg immunoglobulins, and only insignificant amount of igm (separation of g-200 sephadex gel). igg were found to be responsible for the type-specificity of the sera to bacteria, whereas the cross reactions within the h. influenzae genus were connected connected with the igm. use of the sera heated at various temperature regimens of ...	1975	1079105
the "doughnut sign" in subdural effusion.		1975	1079109
counterimmunoelectrophoresis in hemophilus influenzae type b epiglottitis and pericarditis.		1975	1079250
hemophilus influenzae type b susceptibility to 17 antibiotics.	one hundred and one strains of hemophilus influenzae type b isolated at the children's hospital medical center from blood or csf and 18 strains known to be resistant to ampicillin of which 17 were supplied to us by others were tested for their sensitivity to 17 antibiotics. two groups were defined according to their sensitivity to ampicillin. when 10-3 bacteria were applied, 18 strains isolated from patients with ampicillin treatment failures had a median minimum inhibitory concentrations of 3.1 ...	1975	1079251
ampicillin and amoxycillin resistance in haemophilus influenzae.		1975	1079300
initial treatment of meningitis in children.		1975	1079304
hemophilus meningitis: comparison of h. influenzae and h. parainfluenzae.	eleven cases of hemophilus meningitis seen in the last year are reported. three were h. parainfluenzae and eight were h. influenzae. the number of patients is small but probably indicates that there is little difference in the clinical or laboratory data in meningitis caused by these two organisms. the children with h. parainfluenzae tended to be less anemic and had more normal admission spinal fluid sugars and proteins, but this was probably because these patients were older and had shorter pro ...	1975	1079336
neonatal haemophilus influenzae infection. report of eight cases and review of the literature.	eight cases of neonatal haemophilus influenzae infection occurred at colorado general hospital during a 3 1/2-year period. four of the cases were due to nontypable organisms and four to type b organisms. four were bacteremic, only two of which were type b. none of the patients had meningitis. in all instances, maternal genital tract cultures yielded h infleuzae that, when tested, was of the same serotype as the infant isolate. a survey of cervical cultures among normal and pregnant women yielded ...	1975	1079400
letter: haemophilus influenzae cellulitis.		1975	1079466
letter: ampicillin-resistant haemophilus influenzae, type b.		1975	1079560
in vitro resistance of haemophilus influenzae to co-trimoxazole and trimethoprim.	over a period of five months haemophilus influenzae isolated from 123 patients were tested for resistance to co-trimoxazole and trimethoprim by the disc method of sensitivity testing and isolates from four patients were found to be resistant. however, the minimum inhibitory concentrations of trimethoprim lactate were estimated for the isolates from these four patients only one was found to be resistant. this h. influenzae strain was from one of the two patients in the survey who had a history of ...	1975	1079587
action spectrum for the oxygen-indenpendent inactivation of haemophilus influenzae transforming dna with near ultra-violet light.		1975	1079603
the management of thalassemia major.		1975	1079633
severe haemophilus influenzae infections.	from may 1973 thorugh april 1974, a total of 83 children with severe haemophilus influenzae infections were treated in three denver pediatric hospitals. although meningitis was the most common clinical manifestation (45 cases), other foci of infection were also noted (pneumonia, 12 cases; cheek cellulitis, eight cases; epiglottitis, eight cases; empyema, seven cases; pericarditis, three cases; arthritis, one case; periorbital cellulitis, one case; and abscess, one case). nine children had positi ...	1975	1079691
simplified medium for ampicillin susceptibility testing of haemophilus influenzae.	recent reports of bona fide ampicillin resistance among strains of haemophilus influenzae have emphasized the need for improved methods of susceptibility testing of clinical isolates. a simplified medium composed of only mueller-hinton medium plus supplement c (yeast autolysate and hematin) was used successfully for ampicillin susceptibility testing of 20 recent clinical isolates of h. influenzae, including six strains with confirmed ampicillin resistance. with this medium, susceptible strains w ...	1975	1079711
iodometric detection of haemophilus influenzae beta-lactamase: rapid presumptive test for ampicillin resistance.	strains of haemophilus influenzae type b sporadically isolated from clinical specimens are ampicillin resistant due to production of a beta-lactamase. this enzyme which inactivates ampicillin and penicillin g is not produced by ampicillin-susceptible strains. various characteristics of beta-lactamase production and ampicillin resistance of three h. influenzae type b isolates were investigated. a sensitive iodometric test was employed to detect beta-lactamase; positive results were obtained in 5 ...	1975	1079712
ampicillin-resistant strains of hemophilus influenzae.		1975	1079748
studies on bacteriophage m13 dna. 1. a cleavage map of the m13 genome.	a physical map of the bacteriophage m13 genome has been constructed on the basis of specific cleavage of m13 replicative form dna by bacterial restriction endonucleases. the 13 fragments produced by the enzyme from haemophilus aphirophilus (endonuclease r.hap ii) as well as the 10 fragments produced by the enzyme from haemophilus aegyptius (endonuclease r.hae iii) have been ordered by analysis of partial digest products and by analysis of overlapping sets of fragments. in addition, the single si ...	1975	1079769
methylase activities from haemophilus influenzae that protect haemophilus parainfluenzae transforming deoxyribonucleic acid from inactivation by haemophilus influenzae endonuclease r.	specific methylases that have the properties of deoxyribonucleic acid (dna) modification enzymes have been isolated from haemophilus influenzae strain rd. two activities ((methylase iia and methylase iii) were found to protect transforming dna of h. parainfluenzae from the action of h. influenzae restriction enzymes. to determine the specificty of the protection, a procedure based on biological activity was developed for the separation and purification of the restriction endonucleases from h. in ...	1975	1079804
ampicillin-resistant hemophilus influenzae.		1975	1079863
induction of l-forms of haemophilus influenzae in vitro.	the induction of l-forms of haemophilus influenzae by penicillin, amoxycillin and glycine has been studies in vitro on a nutrient-agar medium. the minimal inducing concentrations of the antibiotics were generally the same as their minimal inhibitory concentrations, but the addition of a sub-inducing concentration of glycine lowered the minimal inducing concentration of penicillin. preliminary observations have shown that l-forms are induced by penicillin or amoxycillin on a medium in which mucoi ...	1975	1079876
chloramphenicol today.		1975	1079882
[studies on carrier state of haemophilus influenzae in human upper airways].		1975	1079938
partial antibiotic therapy in haemophilus infuenzae meningitis. its effect on cerebrospinal fluid abnormalities.	to examine the influence of partial antibiotic therapy on laboratory findings in haemophilus influenzae meningitis, 272 untreated cases and 202 partially treated, culture-positive cases from 1953 through 1971 were reviewed. there was no significant difference between the two groups with respect to several cerebrospinal fluid (csf) values. both the untreated and partially treated groups had a similar proportion of cases with negative gram stain and csf glucose level over 40 mg/100 ml or a predomi ...	1975	1080009
letter: neonatal haemophilus influenzae infection.		1975	1080010
diagnostic pitfalls in septic arthritis of the hip in infants and children.		1975	1080089
plasmid-linked ampicillin resistance in haempohilus influenza type b.	four ampicillin-resistant, beta-lactamase-producing strains of haempohilus influenzae type b were examined for the presence of plasmid deoxyribonucleic acid (dna). three resistant strains contained a 30 x 10-6-dalton (30mdal) plasmid and one resitant strain contained a 3-mdal plasmid. the ampicillin-sensitive haemophilus strains examined did not contain plasmid dna. transformation of a sensitive h. influenzae strain to ampicillin resistance with isolated plasmid dna preparations revealed that th ...	1975	1080132
fate of transforming bacteriophage hp1 deoxyribonucleic acid in haemophilus influenzae lysogens.	the biological fate of temperate phage hp1 deoxyribonucleic acid (dna) was followed after uptake by defectively lysogenic competent haemophilus influenzae cultures. the similar inactivation kinetics of three single phage genetic markers and of their triple combination indicated a complete rather than partial destruction of about half of the adsorbed dna molecules. intracellular dna breakdown products were tentatively identified by hydroxyapatite column chromatography as short single strands and ...	1975	1080148
single-strand regions in the deoxyribonucleic acid of competent haemophilus influenzae.	the deoxyribonucleic acid (dna) of competent wild-type haemophilus influenzae and rec1 mutant cells contains single-strand regions, as judged by alkaline sucrose sedimentation, benzoylated naphthoylated diethylaminoethyl-cellulose fractionation, and digestion with an enzyme specific for single-strand regions in dna. in contrast, the dna of competent rec2 cells does not contain single-strand regions. since transforming dna does not associate with recipient dna in the rec2 mutant as it does in wil ...	1975	1080149
capsular polymer of haemophilus influenzae, type b. i. structural characterization of the capsular polymer of strain eagan.	the capsular type-specific antigen of haemophilus influenzae, type b, has been reported to have a unit structure composed of d-ribose and phosphate. recently, the presence of ribitol was found in preparations of type b capsular antigen. our analytical results show equimolar proportions of ribose, ribitol, and phosphate. periodate oxidation studies, paper chromatography of acidic and alkaline hydrolysates, and nmr spectral data indicate the structure of the capular antigen of h. influenzae b, str ...	1975	1080151
effect of previous infection on antibody response of children to vaccination with capsular polysaccharide of haemophilus influenzae type b.	children who had recovered from meningitis, orbital cellulitis, or epiglottitis caused by haemophilus influenzae type b were immunized with capsular polysaccharide vaccine derived from that bacterium; some healthy siblings and adults who had not had h. influenzae infections were also vaccinated. of 10 children who had had h. influenzae meningitis previously, only one had an antibody response to the vaccine. one child with prior h. influenzae orbital cellulitis also failed to respond. none of the ...	1975	1080178
letter: hemophilus influenzae type b: the etiologic agent in epiglottitis.		1975	1080195
figure-8 configuration of dimers of s13 and phix174 replicative form dna.		1975	1080203
studies on bacteriophage fd dna i. a cleavage map of the fd genome.		1975	1080205
studies on bacteriophage fd dna. ii. localization of rna initiation sites on the cleavage map of the fd genome.		1975	1080206
clinical studies on ampicillin-cloxacillin for intravenous injection (rectocillin 'kyowa') (author's transl)].	(1) ampicillin-cloxacillin for intravenous injection (rectocillin 'kyowa') was administered to 9 patients 1 g or 2 g daily for protection of postoperative infections, and good result was obtained in all cases. eight out of 9 cases were with renal insufficiency. no side effect was encountered. (2) rectocillin was administered to 14 patients with infections. the treatment was remarkably effective in 4 cases, and effective in 6 cases. in the cases with renal insufficiency, a daily dose of 1 g was e ...	1975	1080214
nasotracheal intubation in epiglottitis.	significant numbers of patients with epiglottitis have been treated using nasotracheal intubation. evidence is accumulating that this procedure is safe, effective and reliable when used in this disease. nasotracheal intubation should be considered a suitable alternative to tracheostomy in epiglottitis.	1975	1080269
host specificity of dna in haemophilus influenzae: the in vivo action of the restriction endonucleases on phage and bacterial dna.	in haemophilus influenzae strains only the type 1 of the restriction endonucleases have an in vivo effect on phage and bacterial transforming dna. the type 2 of restriction endonucleases which act very efficiently in vitro are completely inactive in vivo. the reasons for this inactivity is unknown.	1975	1080342
infectious arthritis in the neonate caused by haemophilus influenzae.	two newborns had hematogenous pyarthrosis due to haemophilus influenzae. one infant had signs of sepsis and dactylitis involving several fingers and toes. she also developed a soft tissue abscess, meningitis, and a septic hip, and was found to be infected with a nontypable organism. in the second infant, a shoulder traumatized at birth became infected with a type b strain. in both cases, the patients were successfully treated, but delays occurred in selecting the optimal therapeutic agent becaus ...	1975	1080354
constitution of the cell envelope of haemophilus influenzae in relation to competence for genetic transformation.	cell envelopes of haemophilus influenzae have been prepared by breakage in a french pressure cell followed by differential centrifugation. the envelope fraction may be resolved into an inner-membrane (light) and an outer-membrane (heavy) fraction on density gradients. envelopes from competent cells possess elevated levels of lipopolysaccharide with a composition different from that of log-phase cell envelopes. three apparently new polypeptides have been observed in envelopes from competent cells ...	1975	1080485
minicell production and bacteriophage superinducibility of thymidine-requiring strains of haemophilus influenzae.	aminopterin- or trimethoprin-resistant thymidine-requiring strains of haemophilus influenzae produce minicells, and the ratio of minicells to cells increases during the stationary phase of growth. strain lb11, isolated after mutagenesis of a thymidine-requiring strain (rd thd), produces more minicells than the parent strain. the mutations involved in high frequency minicell production have been transferred into the wild type (strain rd) by transformation. the thymidine requirement in the resulti ...	1975	1080486
transfer of ampicillin resistance between strains of haemophilus influenzae type b.	haemophilus influenzae type b, strain w-2, is highly resistant to ampicillin (mic, 12.5 mug/ml). the ampicillin resistance of strain w-2 was transferred to an antibiotic-sensitive strain tf-2 (rifr, smr) during mixed incubation on membrane filters at 36 c(transfeer frequency, 4.6 times 10(-5) per donor). resistance was also transferred from the primary recipient to a secondary one (tf-3, eryr, novr). the transfer frequency between these derivative strains was 10(-4) after incubation for 30 min. ...	1975	1080495
proflavine inactivation of transforming deoxyribonucleic acid irreversibly by dialysis.		1975	1080576
rapid detection of ampicillin-resistant haemophilus influenzae and their susceptibility to sixteen antibiotics.	ampicillin-resistant and -susceptible strains of haemophilus influenzae were tested for susceptibility to 16 antibiotics. chloramphenicol and a new cephalosporin, cefamandole, were most active with minimal inhibitory concentrations (mics) for all bacteria tested between 0.5 to 2.0 mug/ml. all but two organisms were susceptible to tetracycline. ampicillin-resistant strains of h. influenzae were less susceptible (mic, 4 to 32 mug/ml) to carbenicillin and ticarcillin than ampicillin-susceptible org ...	1975	1080656
relationship between beta-lactamase production by haemophilus influenzae and sensitivities to penicillins and cephalosporins.		1975	1080757
mechanism of gap-filling during postreplication repair of ultraviolet damage in haemophilus influenzae.	deoxyribonucleic acid (dna), pulse labeled after ultraviolet irradiation of excision-defective mutants of haemophilus influenzae, is of lower single strand molecular weight than that of unirradiated cells but approaches the size of dna from unirradiated cells upon further incubation in growth medium. this gap-filling process is controlled by the rec-1 gene. gap-filling occurs normally in a temperature-sensitive dna synthesis mutant at the restrictive temperature showing that normal semiconservat ...	1975	1080760
an investigation of the family background of acute haemophilus infections of children.	nose and throat swabs, for culture of haemophilus influenza type b, and blood samples, for measurement of antibodies specific for that serotype, were collected from members of 28 families from which children had been admitted to hospital with acute h. influenzae type b infections (mainly meningitis or epiglottitis). the patients with meningitis were younger than those with epiglottitis and had more siblings, with a marked predominance of sisters. investigations within a few days of admission of ...	1975	1080769
r-factor mediated beta-lactamase production by haemophilus influenzae.	production of beta-lactamase by 15 strains of haemophilus influenzae has been investigated. all the strains produce a constitutive beta-lactamase, which readily hydrolyses penicillin g, ampicillin, and cephaloridine. the beta-lactamase produced by these strains is indistinguishable from the type-iiia enzyme commonly found in strains of escherichia coli. the beta-lactamase gene has been transferred from the enzyme-producing strains of haemophilus to strains of h. parainfluenzae and a strain of e. ...	1975	1080810
an haemophilus influenzae mutant which inhibits the growth of hp1c1 phage.	a strain of haemophilus influenzae, called hpm- inhibits the growth of phage hp1c1 but not s2. this inhibition is overcome by hp1c1ph mutants. phage hp1c1 adsorbs normally to hpm- cells but only a small fraction of infected cells produce phage with a normal burst size or become lysogenic. when hpm- strains lysogenic for hp1c1 are induced, 100 percent of the cells yield phage. there is no degradation of phage dna after infection of hpm- cells and hp1c1 can normally grow when its dna is introduced ...	1975	1080831
tests for the mutagenic actions of a number of chemicals on haemophilus influenzae with special emphasis on hydrazine.	a number of chemicals have been tested for their ability to produce novobiocin-resistant mutants in haemophilus influenzae. of these, hydrazine (hz) proved unique because it induced a fairly high incidence of mutation without killing significant numbers of cells at concentrations ranging over nearly four orders of magnitude. moreover, its dose-effect curve increased very slowly initially and reached a relatively low maximum. it is suggested that hz may be acting as both a mutagen and an antimuta ...	1975	1080833
surveillance for ampicillin-resistant haemophilus influenzae type b strains in north carolina.		1975	1080839
[meningitis caused by ampicillin-resistant h. influenzae].		1975	1080870
letter: staphylococcus aureus antigen in cerebrospinal fluid cross-reactive with haemophilus influenzae type b antiserum.		1975	1080975
[proceedings: isolation of repitive mammalian dna using various restriction endonucleases: localization of eco-ri site of action compared with hydrolysis by hin iii induced fragments].		1975	1081067
influence of prednisone and cytostatics on human blood b-, t- and o-lymphocytes in diseases.	b-, t- and o-lymphocytes detected as eac-, e- and non-rosette forming lymphocytes were investigated in venous blood in 49 patients with connective tissue diseases, psoriasis and chronic lymphogenous leukaemia (cll) during treatment with either prednisone alone, prednisone and cytostatic agents or cytostatic agents alone. prednisone alone did not change the b-, t- and o-lymphocyte counts. cytostatics alone or in combination with prednisone reduced the b- and t-lymphocyte counts concomitant with ...	1975	1081272
six and one-half month old infant with fever and irritability.		1975	1081274
arthrobacter luteus restriction endonuclease cleavage map of phi chi 174 rf dna.		1975	1081295
host specificity of dna in haemophilus influenzae: the physiological and genetical bases of instability of restriction and modification of dna in strain rd.	further investigations of the instability of restriction and modification properties of h. influenzae rd strain were carried out. it has been shown that the instable properties of hsd hind1 system are maintained even after transfer of this system to another h. influenzae strain. the expression of hsd hind1 system is very sensitive to various physiological changes which do not influence the other hsd systems present in the same rd strain. the instability of hsd hind1 system is postulated to be co ...	1975	1081329
perinatal infections caused by haemophilus influenzae.		1975	1081375
the management of septic arthritis in childhood.	a prospective study of one hundred children with septic arthritis showed that the knee and hip were the joints most affected and that staphylococcus aureus and haemophilus influenzae type b were the commonest bacteria grown. our treatment, consisting of early arthrotomy and intravenous methicillin and ampicillin, followed by six weeks of joint immobilization and oral administration of cloxacillin and ampicillin, effectively reversed the inflammatory process and compared very favourably with othe ...	1975	1081390
repair of ultraviolet damage in haemophilus influenzae dna.		1975	1081392
bactericidal substance produced by haemophilus influenzae b.	during bacteriophage studies on haemophilus influenzer, it was observed that encapsulated type b and unencapsulated rb strains released a bactericidal substance acitve against types a, c, d, e, and f h. influenzae, non-typable h. influenzae strains, other haemophilus species, and certain members of the enterobacteriaceae. the bactericidal activity was assayed by a plaque test utilizing an rd strain as an indicator lawn and was also demonstrated in mixed broth cultures of a producer strain and an ...	1975	1081428
hemophilus influenzae septic arthritis in infants and children.		1975	1081439
the nucleotide and amino acid sequences of the n (5') terminal region of gene g of bacteriophage phiphix 174.		1975	1081600
hemophilus influenzae b pericarditis in children.	recent experience in the diagnosis and management of hemophilus influenzae b pericarditis is described in five children. anterior pericardectomy appears to be the preferred method of surgical drainage because it was associated with a shorter hospitalization than pericardiocentesis or closed or open pericardotomy and removed the risk of recurrent cardiac tamponade and constrictive pericarditis. countercurrent immunoelectrophoresis of sera and pericardial fluid was used to rapidly identify the eti ...	1975	1081672
a restriction fragment analysis of the t7 left-early region.		1975	1081780
[characteristics of some species of microorganisms related to the genus of hemoglobinophils].	the saccharolytic capacity in respect to 14 carbohydrates, the lipolytic activity, the presence of urease, catalase, galactosidase, the formation of hydrogen sulphide and indol and also serological properties with the species agglutinating sera were studied in the representatives of the genus of hemoglobinophilic microbes: h. influenzae, h. parainfluenzae, h. aegiptius, h. haemolyticus, h. aphrophilus. there were revealed differences in the individual representatives of the genus by the enzymati ...	1975	1081804