Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| activation of src family kinase yes induced by shiga toxin binding to globotriaosyl ceramide (gb3/cd77) in low density, detergent-insoluble microdomains. | shiga toxin (stx) is an enterotoxin produced by shigella dysenteriae serotype 1 and enterohemorrhagic escherichia coli, which binds specifically to globotriaosylceramide, gb3, on the cell surface and causes cell death. we previously demonstrated that stx induced apoptosis in human renal tubular cell line achn cells (taguchi, t., uchida, h., kiyokawa, n., mori, t., sato, n., horie, h., takeda, t and fujimoto, j. (1998) kidney int. 53, 1681-1688). to study the early signal transduction after stx a ... | 1999 | 10575015 |
| mechanisms of quinolone resistance in clinical isolates of shigella dysenteriae. | 1999 | 10577351 | |
| spontaneous tandem amplification and deletion of the shiga toxin operon in shigella dysenteriae 1. | only one species of shigella, shigella dysenteriae 1, has been demonstrated to produce shiga toxin (stx). stx is closely related to the toxins produced by shiga toxin-producing escherichia coli (stec). in stec, these toxins are often encoded on lambdoid bacteriophages and are major virulence factors for these organisms. although the bacteriophage-encoded stx genes of stec are highly mobile, the stx genes in s. dysenteriae 1 have been believed to be chromosomally encoded and not transmissible. we ... | 1999 | 10594830 |
| promiscuous origin of a chimeric sequence in the escherichia coli o157:h7 genome. | a novel sequence of 2.9 kb in the intergenic region between the muts and rpos genes of escherichia coli o157:h7 and closely related strains replaces a sequence of 6.1 kb in e. coli k-12 strains. at the same locus in shigella dysenteriae type 1, a sequence identical to that in o157:h7 is bounded by the is1 insertion sequence element. extensive polymorphism in the muts-rpos chromosomal region is indicative of horizontal transfer events. | 1999 | 10601221 |
| protein conjugates of synthetic saccharides elicit higher levels of serum igg lipopolysaccharide antibodies in mice than do those of the o-specific polysaccharide from shigella dysenteriae type 1. | our development of vaccines to prevent shigellosis is based on the hypothesis that a critical (protective) level of serum igg to the o-specific polysaccharide (o-sp) domain of shigella lipopolysaccharide (lps) confers immunity. the o-sp is a hapten and must be conjugated to a protein to induce serum antibodies. the o-sp of shigella dysenteriae type 1 (approximately 27 tetrasaccharide repeat units), prepared by acid hydrolysis of the lps, was bound to human serum albumin (hsa) by multiple point a ... | 1999 | 10220442 |
| an epidemic of bloody diarrhea: escherichia coli o157 emerging in cameroon? | between november 1997 and april 20, 1998, bloody diarrhea sickened 298 persons in cameroon. laboratory investigation of the epidemic (case-fatality rate, 16.4%) documented amoebiasis in one of three patients and three types of pathogens: multidrug-resistant shigella dysenteriae type 1, s. boydii, and enterohemorrhagic escherichia coli. we report the first isolation of e. coli o157:h7 in cameroon and the second series of cases in the central african region. | 1999 | 10221885 |
| lethality of a heat- and phosphate-catalyzed glucose by-product to escherichia coli o157:h7 and partial protection conferred by the rpos regulon. | a by-product of glucose produced during sterilization (121 degrees c, 15 lb/in2, 15 min) at neutral ph and in the presence of phosphate (i.e., phosphate-buffered saline) was bactericidal to escherichia coli o157:h7 (atcc 43895). other six-carbon (fructose and galactose) and five-carbon (arabinose, ribose, and xylose) reducing sugars also produced a toxic by-product under the same conditions. fructose and the five-carbon sugars yielded the most bactericidal activity. glucose concentrations of 1% ... | 1999 | 10347019 |
| shiga/verocytotoxins and shiga/verotoxigenic escherichia coli in animals. | vero/shiga toxins (vt/stx) have an a-b structure: the a subunit carries the enzymatic activity and the b subunit binds the toxin to the membrane receptor (gb3 or gb4). the vt/stx inhibit protein synthesis in the target eucaryotic cells, mainly the endothelial cells of blood vessels. the vt/stx are subdivided into two families. vt1/stx1 is a homogeneous family of toxins identical to the stx of shigella dysenteriae. vt2/stx2 is a more heterogeneous family of toxins more distantly related to this s ... | 1999 | 10367357 |
| the so-called chromosomal verotoxin genes are actually carried by defective prophages. | 1999 | 10382973 | |
| the aerobactin iron transport system genes in shigella flexneri are present within a pathogenicity island. | genes encoding the synthesis and transport of aerobactin, a hydroxamate siderophore associated with increased virulence of enteric bacteria, were mapped within a pathogenicity island in shigella flexneri. the island, designated shi-2 for shigella pathogenicity island 2, was located downstream of selc, the site of insertion of pathogenicity islands in several other enteric pathogens. dna sequence analysis revealed the presence of multiple insertion sequences upstream and downstream of the aerobac ... | 1999 | 10411724 |
| molecular characterization of the shv-11 beta-lactamase of shigella dysenteriae. | a beta-lactamase with an m(r) of 29,000 and a pi of 7.6 was partially purified from a clinical isolate of shigella dysenteriae. the bla gene encoded the shv-11 enzyme carrying the substitution leu-->gln at position 35 and was linked to a strong promoter. this variant, unlike the prototype shv-1 enzyme, hydrolyzed oxacillin, cloxacillin, and oxyiminocephalosporins such as cefotaxime. | 1999 | 10428943 |
| [the serum bactericidal activity of domestic fleroxacin and lomefloxacin]. | to evaluate antibacterial activities in vivo and in vitro of fleroxacin and lomefloxacin. | 1999 | 11798634 |
| impaired imipenem uptake associated with alterations in outer membrane proteins and lipopolysaccharides in imipenem-resistant shigella dysenteriae. | three imipenem-resistant mutants were obtained from a clinical isolate (c152) of shigella dysenteriae by selection with increasing concentrations of imipenem. resistance to imipenem was associated with resistance to several other beta-lactam antibiotics. the penicillin-binding protein (pbp) patterns of the resistant and the wild-type strains were comparable. the permeability of the outer membrane proteins (omps) of the most resistant mutant, im16, was lower than that of the parent strain c152 wh ... | 1999 | 11252324 |
| antimicrobial agent resistance in bacterial isolates from patients with diarrhea and urinary tract infection in the sudan. | antimicrobial sensitivity tests were performed on four-hundred and ninety-seven bacterial isolates from sudanese patients with diarrhea or urinary tract infections. shigella dysenteriae type i and enteropathogenic escherichia coli showed high resistance rates (percentage of isolates showing antibiotic resistance) against the commonly-used antimicrobial agents: ampicillin, amoxicillin, chloramphenicol, tetracycline, cotrimoxazole, nalidixic acid, sulfonamide, and neomycin, and were completely sen ... | 2000 | 11421374 |
| [effect of irradiation on the shelf-life of aquatic products]. | the effect of irradiation at doses of 0-10 kgy on the shelf-life of aquatic products was determined. the results showed that irradiation could not prolong the shelf-life of aquatic products kept at 25 degrees c. while the aquatic products were kept at refrigerator (4 degrees c), the irradiation could prolong the shelf-life and effectively reduce the total aerobic plate count. irradiation could effectively reduce the number of coliform to less than 300/kg and eliminate shigella shigae, salmonella ... | 2000 | 12725095 |
| i-ceui fragment analysis of the shigella species: evidence for large-scale chromosome rearrangement in s. dysenteriae and s. flexneri. | i-ceui fragments of four shigella species were analyzed to investigate their taxonomic distance from escherichia coli and to collect substantiated evidence of their genetic relatedness because their ribosomal rna sequences and similarity values of their chromosomal dna/dna hybridization had proved their taxonomic identity. i-ceui digestion of genomic dnas yielded seven fragments in every species, indicating that all the shigella species contained seven sets of ribosome rna operons. to determine ... | 2000 | 10612738 |
| production of ifn-gamma and il-10 to shigella invasins by mononuclear cells from volunteers orally inoculated with a shiga toxin-deleted shigella dysenteriae type 1 strain. | volunteers were orally administered invasive, non-shiga toxin-producing shigella dysenteriae 1 to establish a challenge model to assess vaccine efficacy. in stepwise fashion, four separate groups were given 3 x 10(2), 7 x 10(3), 5 x 10(4), or 7 x 10(5) cfu. using pbmc, proliferative responses and cytokine production were measured to s. dysenteriae whole-cell preparations and to purified recombinant invasion plasmid ags (ipa) c and ipad. anti-lps and anti-ipa abs and ab-secreting cells were also ... | 2000 | 10657678 |
| effects of caffeic acid, chlorogenic acid and ferulic acid on growth and arylamine n-acetyltransferase activity in shigella sonnei (group d). | arylamine n-acetyltransferase (nat) activities with 2-aminofluorene (2-af) as substrates were determined in shigella sonnei (group d) collected from patients with diarrhoeal disease. the nat activity was determined using an acetyl coa recycling assay and high pressure liquid chromatography. inhibition of growth studies from s. sonnei (group d) demonstrated that caffeic acid (ca), chlorogenic acid (cga) and ferulic acid (fa) elicited a dose-dependent bactericidal effect in s. sonnei (group d) cul ... | 2000 | 10677842 |
| evaluation of antibacterial activity of asparagus racemosus willd. root. | different concentrations (50, 100, 150 microg/ml) of the methanol extract of the roots of asparagus racemosus willd. showed considerable in vitro antibacterial efficacy against escherichia coli, shigella dysenteriae, shigella sonnei, shigella flexneri, vibrio cholerae, salmonella typhi, salmonella typhimurium, pseudomonas putida, bacillus subtilis and staphylococcus aureus. the effects produced by the methanol extract were compared with chloramphenicol. | 2000 | 10685109 |
| blocking bacterial enterotoxins. | 2000 | 10700222 | |
| a new biological agent for treatment of shiga toxigenic escherichia coli infections and dysentery in humans. | gastrointestinal disease caused by shiga toxin-producing bacteria (such as escherichia coli o157:h7 and shigella dysenteriae) is often complicated by life-threatening toxin-induced systemic sequelae, including hemolytic-uremic syndrome. such infections can now be diagnosed very early in the course of the disease, but at present no effective therapeutic intervention is possible. here, we constructed a recombinant bacterium that displayed a shiga toxin receptor mimic on its surface, and it adsorbe ... | 2000 | 10700227 |
| induction of mrna for tumor necrosis factor-alpha and interleukin-1 beta in mice brain, spleen and liver in an animal model of shigella-related seizures. | the pathogenesis of neurological symptoms, the most common extraintestinal complication of childhood shigellosis, is unclear. to elucidate the mechanisms involved, we developed an animal model and demonstrated that tnf alpha and il-1 beta play a role. | 2000 | 10804924 |
| synthesis of the tetrasaccharide related to the repeating unit of the antigen from shigella dysenteriae type 5. | starting from l-rhamnose, d-mannose and 2-amino-2-deoxy-d-glucose hydrochloride, two disaccharide blocks, namely, ethyl 2,4-di-o-benzyl-3-o-[(r)-1-(methoxycarbonyl)ethyl]-alpha-l-rhamnopyranos yl-(1-->3)-2-o-acetyl-4,6-di-o-benzyl-1-thio-alpha-d-mannopyranoside and 2-(trimethylsilyl)ethyl 2-o-acetyl-3,6-di-o-benzyl-alpha-d-mannopyranosyl-(1-->3)-4,6-di-o-benzy l-2-deoxy-2-phthalimido-beta-d-glucopyranoside, were synthesised and then allowed to react in the presence of n-iodosuccinimide and trifl ... | 2000 | 10839118 |
| disease-dependent changes in t-cell populations in patients with shigellosis. | in shigellosis, bacterial infection is associated with an extensive inflammation of the rectal mucosa, resulting in bloody dysentery. the role of t-cell-mediated pro-inflammatory mechanisms has been implicated in this process, but the specific role of t-cell subsets is still not well understood. in this study we attempted to identify the changes in t-cell populations in patients with shigellosis during the disease course. the t-cell subset distribution was analyzed by immunohistochemistry in the ... | 2000 | 10843411 |
| antibacterial activity of a chitooligosaccharide mixture prepared by cellulase digestion of shrimp chitosan and its application to milk preservation. | the antibacterial activity of a chitooligosaccharide mixture prepared by digestion of shrimp chitosan with cellulase at 50 degrees c for 14 h was evaluated. sugars with 1 to 8 degrees of polymer (dp) were found in this chitooligosaccharide mixture, and the weight percentage of sugars with dp > or = 6 was 44.3%. minimal lethal concentrations of this mixture against aeromonas hydrophila, escherichia coli, listeria monocytogenes, pseudomonas aeruginosa, salmonella typhimurium, shigella dysenteriae, ... | 2000 | 10852568 |
| pcr detection of giardia lamblia in stool: targeting intergenic spacer region of multicopy rrna gene. | a pcr based detection that amplifies the 552-bp intergenic spacer (igs) region of multicopy rrna gene of giardia lamblia and 320-bp internal sequences to first pcr product has been used in diagnosis of giardiasis in stool sample. the primers were found highly specific to giardia spp. only, because no amplification was observed with dnas from other enteric pathogens like escherichia coli, shigella dysenteriae and entamoeba histolytica. the test could detect even less than 2 pg of genomic dna from ... | 2000 | 10860716 |
| nmr spectroscopy, molecular dynamics, and conformation of a synthetic octasaccharide fragment of the o-specific polysaccharide of shigella dysenteriae type 1. | a synthetic octasaccharide fragment (2) of the o-specific polysaccharide (1) of shigella dysenteriae type 1 has been studied as its methyl glycoside by one- and two-dimensional homo- and heteronuclear nmr spectroscopy. complete 1h and 13c nmr assignments have been generated, and the 13c spin-lattice relaxation times have been measured for the octasaccharide 2. a congener (6) of this octasaccharide containing one d-galactose residue with a specific 13c label at c-1 has been synthesized and used t ... | 2000 | 10723612 |
| antimicrobial resistance trends in shigella serogroups isolated in israel, 1990-1995. | from a total of 31319 shigella strains isolated in israel between 1990 and 1996, 17574 were sent to the national shigella reference center for typing. of these, 15287 were identified as shigella sonnei, 1833 as shigella flexneri, 327 as shigella boydii and 127 as shigella dysenteriae. in all, 4395 strains were tested for sensitivity to ampicillin, trimethoprim-sulfamethoxazole, tetracycline, chloramphenicol, nalidixic acid and ofloxacin. all strains tested were sensitive to ofloxacin, and only t ... | 2000 | 10746496 |
| [effect of hydroxylamine hydrochloride on lipopolysaccharide fatty acid composition in shigella dysenteriae 1]. | changes in the fatty acid composition of s. dysenteriae 1 lipid a after the treatment of lipopolysaccharide (lps) with hydrosylamine hydrochloride (hh) and 4 degrees c, 37 degrees c and 56 degrees c were studied with the use of gas-liquid chromatographicmass-spectrometry. the treatment with hh led to a decrease in the toxicity of lps, but produced no changes in the content of the main fatty acid components of lipid a (lauric, myristic, oxymyristic and palmitic acids). at the same time the total ... | 2000 | 11210628 |
| an outbreak of dysentery in a rural district of zimbabwe: the role of personal hygiene at public gatherings. | to characterize the nature and extent of the outbreak; to determine the risk factors associated with contracting shigellosis; and to institute disease control and preventive measures. | 2000 | 11235056 |
| structural analysis of phage-borne stx genes and their flanking sequences in shiga toxin-producing escherichia coli and shigella dysenteriae type 1 strains. | the stx-flanking regions of 49 shiga toxin-producing escherichia coli strains and nine shigella dysenteriae serotype 1 strains containing either stx, stx(1), stx(2), or stx(2) variant genes, were examined. we analyzed these regions by pcr using a set of primers with one primer specific for the respective stx gene and a second primer complementary to sequences of stx phages h-19b and 933w. we further characterized the amplification products by restriction endonuclease digestion and nucleotide seq ... | 2000 | 10948097 |
| [acute encephalopathy in children: a serious illness after an inauspicious beginning]. | three young children, 2 girls of 6 and 3.5 years and 1 boy aged 3.5 years, had complaints like vomiting and fever of what initially was thought to be a minor infection. however, their condition deteriorated within two days to such an extent that they died while being treated on the intensive care department. the rapid drop in consciousness, sometimes accompanied by convulsions, is an expression of increased intracranial pressure resulting from diffuse brain oedema, which itself is probably cause ... | 2000 | 10965363 |
| escherichia coli shiga toxin. | the stx family contains two types called stx1 (verotoxin 1: vt1 or shiga-like toxin: slt1) and stx2 (vt2, slt2); both toxins are encoded by bacteriophages. stx1 is identical to shiga toxin produced by shigella dysenteriae type i. stx2 is heterogeneous and immunologically different from stx1. although many variations are found in stx family, all stx has an a-b structure: the a subunit has n-glycosidase activity and the b subunit binds to a membrane glycolipid, globotriaosylceramide (gb3). the a s ... | 2000 | 10994531 |
| characterization and expression of hmur, a tonb-dependent hemoglobin receptor of porphyromonas gingivalis. | the gram-negative pathogen porphyromonas gingivalis requires hemin for growth. hemoglobin bound to haptoglobin and hemin complexed to hemopexin can be used as heme sources, indicating that p. gingivalis must have a means to remove the hemin from these host iron-binding proteins. however, the specific mechanisms utilized by p. gingivalis for the extraction of heme from heme-binding proteins and for iron transport are poorly understood. in this study we have determined that a newly identified tonb ... | 2000 | 11004172 |
| role of porin of shigella dysenteriae type 1 in modulation of lipopolysaccharide mediated nitric oxide and interleukin-1 release by murine peritoneal macrophages. | the ability of shigella dysenteriae type 1 porin to induce the release of nitric oxide (no) and interleukin-1 (il-1) from peritoneal macrophages of mouse and to regulate lipopolysaccharide (lps) and gamma interferon (ifn-gamma) mediated release of the two proinflammatory mediators was investigated. porin released nitrite when added to macrophage cultures. a maximum of 3.2-fold nitrite release by macrophages was observed with 100 ng ml(-1) of porin. the nitrite release of lps was enhanced signifi ... | 2000 | 11024352 |
| tonb is required for intracellular growth and virulence of shigella dysenteriae. | to assess the importance of tonb-dependent iron transport systems to growth of shigella in vivo, a tonb mutant of shigella dysenteriae was isolated and tested in cultured cells. the tonb mutant invaded epithelial cells, but did not form plaques in confluent monolayers of henle cells, indicating an inability of this mutant to spread from cell to cell. the rate of intracellular multiplication of the tonb mutant was reduced significantly compared to that of the wild type. the loss of virulence in t ... | 2000 | 11035742 |
| a novel is-like element frequently inserted in a putative virulence regulator in bovine mastitis isolates of streptococcus dysgalactiae. | streptococcus dysgalactiae, a lancefield group c streptococcus, is commonly isolated from bovine mastitis. we recently identified a putative regulon in two s. dysgalactiae strains, 8215 and epi9, consisting of two consecutive genes, dmg and dem, coding for a possible regulatory protein and an m-like protein with fibrinogen- and igg-binding-properties, respectively. during these studies a short sequence homologous to an is element was found to be inserted in the dmg gene of strain 8215. the prese ... | 2000 | 11078648 |
| [shigella bacteraemia: a report of two cases observed in dakar]. | shigellosis is usually a self-limiting enteric disease, rarely accompanied by extra-intestinal manifestations. in senegal, shigella bacteraemia is poorly documented. the authors report two retrospective cases of shigella dysenteriae 1 bacteraemia in an infant aged 12 months and a 32 years-old adult admitted at the infectious diseases clinic in dakar. in both cases, a fatal outcome was observed, in relation to complications: endotoxic shock in the infant, severe intestinal haemorrhage in the adul ... | 2000 | 15779184 |
| the lymphocyte inhibiting factor extracted from the thymus (lift): inhibition of the dna synthesis in vitro. | 2000 | 1083769 | |
| antimicrobial potency of the leaf - stalk extract of curcuma longa (linn). | the methanolic extract of the leaf-stalk of curcuma longa linn, was tested for its minimum inhibitor concentration (mic) against gram positive-staphylococcus aureus, bacillus pumilus, bacillus subtilis, klebsiella pnemoniae, bacillus cereus, streptococcus pneumoniae, lactobacillus arabinosus and gram negative e.coli, shigella dysenteriae, shigella sonnei, shigella boydii, salmonella typhimurium, proteus mirabilis, and vibrio cholerae strains, further, the ones of inhibition produced by the crude ... | 2000 | 22557005 |
| a standardized estimator of the prevalence of alcoholism based on mortality data. | death rates from alcohol-related causes correlated with over-all mortality and reflected general health conditions and demographic characteristics as well as the prevalence of alcoholism. | 2000 | 314021 |
| [cryptorchism: hormonal treatment]. | 2000 | 27065 | |
| [conduction of disorders after total correction of fallot's tetralogy. electrocardiographic and electrophysiological study]. | the conduction defects observed after total correction of fallot's tetralogy in 133 children, and their association with the long term outcome were studied with comparison of pre and postoperative electrocardiograms and, in 26 cases, his bundle recording. 23 early complete heart blocks were recorded which were nearly always transient. only 4 (3.6%) became permanent. 58 had a right bundle branch block (48.4%) and 19 a bifascicular block (15.8%). the early operative mortality (9.7%) appeared to be ... | 2000 | 86328 |
| serum isoamylases in diseases of the lung and control subjects of thermolabile serum amylase component. | 2000 | 94301 | |
| [results of operative treatment of acute perforating gastroduodenal ulcer (author's transl)]. | in this report of 264 operatively treated gastroduodenal perforations, differentiated, and where possible definitive, therapy is attempted. by omitting simple oversewing in favor of primary resection, bionomic operation or the combined procedure, primary lethality is reduced to one third and the late results of the survivors significantly improved. resections are indicated in benign pyloric stenosis and gastric ulcer. the bionomic operation is particularly to be preferred in young patients. | 2000 | 101776 |
| seizure after infusion of aminocaproic acid. | 2000 | 101682 | |
| some factors, influencing the sensitivity of the antibody screening the groupamatic 360 system. | 2000 | 97759 | |
| reconstruction of the auricle. | 2000 | 94728 | |
| disorders of chloriuretic hormone secretion. | experimental evidence supports the existence of a circulating substance, natriuretic hormone, which augments electrolyte excretion. because such a hormone probably acts by inhibiting chloride reabsorption in the thick, ascending limb of the loop of henle it would more accurately be called chloriuretic hormone. chloriuretic hormone must have an action which resembles that of loop diuretics such as frusemide and ethacrynic acid. an excess of chloriuretic hormone could explain all the manifestation ... | 2000 | 86837 |
| effect of dietary composition on fasting-induced changes in serum thyroid hormones and thyrotropin. | 2000 | 97492 | |
| [specificity of antitumoral substances]. | 2000 | 92004 | |
| hyponatremia. | 2000 | 97245 | |
| ige production and suppression. carrier-specific and normal t-cell interactions in suppression. | 2000 | 91964 | |
| localization of murine ig-1b and ig-1a (igg 2a) allotypic determinants detected with monoclonal antibodies. | 2000 | 94425 | |
| review of laxative utilization in a skilled nursing facility. | laxatives are the most frequently prescribed drugs in long-term care facilities. of all nursing home patients, 58 percent receive laxatives--often more than one, and usually on a "prn" basis. this pattern of dosage is probably used in an effort to prevent constipation. selection of a laxative should be based on careful evaluation of the cause of constipation, with due consideration being given to differences in drug effectiveness and the incidence of side effects. a review of laxative utilizatio ... | 2000 | 101574 |
| interactions between polycyclic hydrocarbons and lipids in model membranes [proceedings]. | 2000 | 94797 | |
| emergency arteriography in acute gastrointestinal bleeding. | emergency arteriography was carried out on 35 patients with acute gastrointestinal bleeding, in 31 of them within two hours of active bleeding (a haematemisis; a diagnostic change in central venous pressure, pulse rate, or blood pressure; or gastric aspiration of fresh blood). a definite site of bleeding was identified in 27 patients (77%)-this being a small-intestinal vascular abnormality in three--and a probable site in three. confirmation of the bleeding site was obtained in 20 out of 23 pati ... | 2000 | 1083756 |
| is serum total cholesterol outmoded? | 2000 | 91908 | |
| failure of anti-d immunoglobulin to remove fetal red cells from maternal circulation. | a rhesus negative female was found post delivery to have circulating cells of fetal origin. the neonate was typed as d-positive. in spite of more than conventionally adequate doses of anti-d immunoglobulin given to the mother, the fetal cell count in the maternal circulation remained unchanged. further investigation showed the fetus to be a du variant and to exhibit a diminished reaction with the batch of anti-d immunoglobulin used. | 2000 | 111422 |
| delayed hemolytic transfusion reactions. | 2000 | 101679 | |
| sensitivity of spleen-colony-forming units to chronic bleomycin. | 2000 | 92329 | |
| serum-myelin-basic-protein assay in diagnosis and prognosis of patients with head injury. | serum levels of myelin basic protein (m.b.p.), a nervous-system-specific protein, were measured in 157 patients after head injury and related both to the type of brain damage and to the clinical outcome assessed three months after injury. mean concentrations of m.b.p. in patients with severe intracerebral damage, with or without associated extracerebral haematoma, were significantly raised at the time of admission and remained high for two weeks after injury. in patients with extracerebral haema ... | 2000 | 87549 |
| levodopa boosts intellectual rating in senile dementia. | 2000 | 101689 | |
| [importance of close observation of the patient and confirmation of the findings]. | 2000 | 97450 | |
| reduced plasma viscosity among joggers compared with non-joggers. | 2000 | 92344 | |
| use of the fluorochrome 4'6-diamidino-2-phenylindole in genetic and developmental studies of chloroplast dna. | use of the dna-specific fluorochrome 4'6-diamidino-2-phenylindole (dapi) makes it possible to examine in situ the structure of chloroplast dna (chdna) with the fluorescence microscope. this simplifies the study of genetic and developmental changes in chloroplast dna. three examples are presented. (a) wild-type euglena gracilis b contains several chloroplast dna nucleoids per chloroplast. a yellow mutant lacking functional chloroplasts is similar, but such nucleoids are absent in an aplastidic mu ... | 2000 | 90051 |
| a thymus-independent igg response against dextran b512 can be induced in c57bl but not in cba mice, even though both strains possess a vhdex gene. | cba and c57bl mice both possess a vhdex gene coding for antibodies against the alpha 1-6 epitope of dextran b512. after immunization with dextran, cba mice produce igm plaque-forming cells (pfc) only, which show regular cyclical fluctuations. the second pfc peak disappeared after injection of dextranase, indicating that it is antigen-dependent. the anti-dextran response in c57bl mice is characterized by only one igm peak, followed 1 day later by an igg peak that may exceed the igm response by a ... | 2000 | 94695 |
| establishment of two medical colleges in nwfp. | 2000 | 97411 | |
| world survey on cardiac pacing. | 2001 | 95323 | |
| neonatal tolerance to k and d region alloantigens of h-2 complex: i-j region requirements. | 2001 | 88101 | |
| sex ratio in glomerulonephritis. | 2001 | 87939 | |
| hla homozygosity and neural-tube defects. | 2001 | 87795 | |
| testing meningococcal vaccines for mitogenicity and superantigenicity. | proteins with intrinsic mitogenic properties are widely represented in prokaryotes, such as in different streptococcus species (1-3), candida albicans (4), and eikenella corrodens (5). specifically, several bacterial porins of escherichia coli, shigella dysenteriae, salmonella typhimurium, fusobacterium nucleatum, and pathogenic neisseria species have been shown to induce nonspecific proliferation of lymphocytes (6-12). | 2001 | 21336757 |
| congenital cutis laxa and maternal d-penicillamine. | 2001 | 88570 | |
| perinatal mortality. | 2001 | 93220 | |
| observations on 160 patients with peripheral facial paralysis seen in private practice. | 2001 | 98678 | |
| ddavp and cryoprecipitate in mild haemophilia. | 2001 | 90263 | |
| a blood drive model for health education projects. | 2001 | 98507 | |
| [contribution of drug therapy to the efficiency in health care delivery]. | 2001 | 98692 | |
| [new data on glycosaminoglycans and proteoglycans]. | the most important investigations on glycose aminoglycans and proteoglycans, carried out within the recent 5-7 years, are reviewed. data on primary structures repeating in glycose aminoglycans and on relationship between these biopolymers and protein components in proteoglycans are considered. newer information on conformational characteristics of glycose aminoglycans, various complexes aggregation of proteoglycans and distribution of the biopolymers in animal tissues and cells is discussed. pro ... | 2001 | 88130 |
| behaviour of alpha1-antitrypsin in lung cancer. | 2001 | 98836 | |
| [palliative therapy of stenosing reflux esophagitis]. | 2001 | 93354 | |
| enzyme immunoassays revisited. | 2001 | 90867 | |
| sodium cromoglycate (intal) in the management of chronic leg ulcers. | 2001 | 98691 | |
| flashbacks: ventricular fibrillation part i. | 2001 | 95318 | |
| [successful exclusively tube feeding over a period of 21 months in a cranio-cerebral injury with the apallic syndrome]. | 2001 | 99629 | |
| axoplasmic transport blockage therapy in herpes zoster ophthalmicus. | three patients with herpes zoster ophthalmicus were treated with an oral administration of colchicine and corticosteroid, while another seven were given systemic corticosteroid, vitamins, and sedatives. colchicine inhibited the formation of new skin lesions but did not suppress the already grown vesicles. the effect of colchicine was attributed to a blockage of intra-axonal dissemination by neurotrophic virus. | 2001 | 92895 |
| the hook sign in type 3 congenital colonic atresia. | 2001 | 98027 | |
| infertility in a potto. | 2001 | 97850 | |
| ataxia-telangiectasia and hepatocellular carcinoma. | ataxia-telangiectasia (at) is a multi-system disease involving the cerebellum, cutaneous blood vessels and the immune system including both cellular and humoral components. it also involves hematological, endocrine and peripheral nervous systems. this disease is often associated with abnormal liver function tests, such as, raised alkaline phosphatase and various nonspecific histological changes in the liver. high incidence of various malignancies involving lymphoreticular, gastrointestinal and m ... | 2001 | 92892 |
| psychological troubles at the menopause. | 2001 | 87786 | |
| the effect of heat shock on gene expression in drosophila melanogaster. | 2001 | 98271 | |
| anticonvulsant action of a 1,5-benzodiazepine, clobazam, in reflex epilepsy. | clobazam, an anxiolytic 1,5-benzodiazepine, has been evaluated as an anticonvulsant in 2 animal models. in mice showing sound induced seizures, clobazam, 1--4 mg/kg, i.p., blocked seizure responses for 1--2 hr. in senegalese baboons papio papio showing photically induced myoclonus or seizures, clobazam, 2--12 mg/kg, i.v., totally prevented such responses for up to 6 hr. in baboons pretreated with allylglycine, 170--185 mg/kg, a similar but briefer protection was induced by clobazam. neurological ... | 2001 | 98317 |
| prevention through mental health. | 2001 | 98494 | |
| performance of blood-glucose meters. | 2001 | 87872 | |
| regional differences in tumor growth: studies of the vascular system. | 2001 | 98454 | |
| ethanol, disulfiram, and pyrazole: effects on interferon production in mice. | the effects of ethanol alone or combined with pyrazole or disulfiram were studied in reference to interferon production. saline, ethanol (2 g/kg), pyrazole (2 mg/kg), or disulfiram (2 mg/kg) were injected, intraperitoneally, 3 hr after poly i:c, an interferon inducer. drugs were administered either by a single injection, or twice daily for 7 days, and the mice were sacrificed 6 hr after poly i:c. sera from mice were pooled, dialyzed, and assayed for interferon by the microplaque reduction method ... | 2001 | 95409 |
| runaway cordis omni-stanicor pacemaker. | 2001 | 95306 | |
| [syndrome of familial polycystic ovaries (stein-leventhal type): serum levels of luteinizing and follicle stimulating hormones before and after wedge resection of the ovaries]. | 2001 | 311042 | |
| efficiency of utilization of a computed tomography scanner. | efficient utilization of diagnostically effective but expensive computed tomography (ct) brain scanners requires understanding of time factors influencing patient throughput. in a study at ucla medical center using an emi mark i brain scanner, the average number of patients studied was 16.3 per 15.5 hr workday, for an average of 52.7 min per patient. of the patients, 51.5% were inpatients at ucla, 45% received intravenous iodinated constrast infusion, and 33% had studies showing significant abno ... | 2001 | 97991 |