Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| the epidemiology of low serum pepsinogen a levels and an international association with gastric cancer rates. eurogast study group. | low serum levels of pepsinogen a are indicative of chronic atrophy, a risk factor for gastric cancer. this study investigated the relationships between low pepsinogen a levels, helicobacter pylori seropositivity, and gastric cancer rates in 17 populations worldwide. | 1994 | 7926498 |
| helicobacter pylori reinfection: what's the risk? | 1994 | 7926524 | |
| the proton pump inhibitor omeprazole inhibits acid survival of helicobacter pylori by a urease-independent mechanism. | omeprazole, a benzimidazole proton pump inhibitor, has an antibacterial effect against helicobacter pylori at neutral ph and inhibits its urease activity. the aim of this study was to characterize h. pylori acid resistance and to determine whether omeprazole effects its survival at low ph. | 1994 | 7926527 |
| duodenal ulcer, helicobacter pylori, and gastric secretion. | patients with chronic dyspepsia were categorised by macroscopic appearance at oesophagogastroduodenoscopy as having duodenal ulceration (du), other diagnosed lesions such as reflux oesophagitis, carcinoma of stomach, etc, or no organic lesion (non-ulcer dyspepsia, nud). material was collected to identify gastric infection with helicobacter pylori (h pylori) by cp urease test, culture, and histological examination and to make the microscopic diagnosis of active chronic gastritis. each patient in ... | 1994 | 7926901 |
| helicobacter pylori in peptic ulcer disease. | the national institutes of health consensus development conference on helicobacter pylori in peptic ulcer disease brought together specialists in gastroenterology, surgery, infectious diseases, epidemiology, and pathology, as well as the public, to address the following questions: (1) what is the causal relationship of h. pylori to upper gastrointestinal disease? (2) how does one diagnose and eradicate h. pylori infection? (3) does eradication of h. pylori infection benefit the patient with pept ... | 1994 | 7920747 |
| some personal comments on the sydney system for the classification of chronic gastritis. | the sydney system for the classification of chronic gastritis is a system for describing the histopathological findings of a biopsy specimen. it involves the analysis of two to four biopsies of the gastric mucosa taken from arbitrary sites, which, taken alone, are insufficient for extrapolation to the diagnosis of the whole stomach. the system seems to be useful as a computer-oriented method fo documenting the histopathological analysis of the two to four biopsy specimens obtained from the arbit ... | 1994 | 7921142 |
| immunization of balb/c mice against helicobacter felis infection with helicobacter pylori urease. | because helicobacter pylori is a potentially dangerous human pathogen, the protective potential of oral immunization with h. pylori urease and its subunits was evaluated in an animal model. | 1994 | 7926454 |
| acid and gastric metaplasia in the duodenum. | 1994 | 7926926 | |
| gastrointestinal lymphoma. | primary gastrointestinal lymphoma comprises a group of distinctive clinicopathological entities, most of which are not included in current lymph node-based lymphoma classifications. they may be of b- or t-cell type, with primary gastrointestinal hodgkin's disease being extremely uncommon. most low grade b-cell gastrointestinal lymphomas are of mucosa-associated lymphoid tissue (malt) type, so called because they recapitulate the features of malt rather than those of lymph nodes. paradoxically, h ... | 1994 | 7927306 |
| metabolism of pyruvate and glucose by intact cells of helicobacter pylori studied by 13c nmr spectroscopy. | the metabolic routes of substrate catabolism by intact cells of h. pylori have been investigated by 13c nmr. real time analyses of metabolic transformations under anaerobic conditions have been obtained with dense cell suspensions incubated with 13c-labelled pyruvate and glucose. in addition, time point studies have been carried out with cells incubated under aerobic conditions. anaerobically, pyruvate was rapidly metabolized to lactate, ethanol and acetate. in addition, alanine was produced in ... | 1994 | 7921258 |
| laboratory medicine in ulcer disease. | the role of laboratory medicine in ulcer disease is poorly defined. however there is increasing evidence of the clinical usefulness of some laboratory tests that investigate secretory functions and defensive properties of the stomach, gastrointestinal hormones and helicobacter pylori infection. these tests may modify the clinical management of patients with peptic ulcer by identifying h. pylori positive subjects, patients with high acid output, patients who do not respond to antisecretory therap ... | 1994 | 7923753 |
| [gastric cancer: a long-term consequence of helicobacter pylori infection?]. | 1994 | 7926430 | |
| risk factors for helicobacter pylori. | 1994 | 7926927 | |
| [helicobacter pylori and molecular biology. applications to pathogenesis, prevention, diagnosis and epidemiology]. | 1994 | 7926434 | |
| [gastric infections with helicobacter pylori]. | 1994 | 7926435 | |
| [direct and indirect diagnostic methods for helicobacter pylori infections]. | 1994 | 7926436 | |
| [how to eradicate helicobacter pylori?]. | 1994 | 7926437 | |
| expression of antral gastrin and somatostatin mrna in helicobacter pylori-infected subjects. | we investigated the gene expression of antral gastrin and somatostatin in helicobacter pylori-infected subjects. twelve asymptomatic men with normal endoscopic findings participated in this study, four of whom were infected with h. pylori. | 1994 | 7915874 |
| peptic ulcer disease: what is the role for helicobacter pylori? | 1994 | 7915181 | |
| [is small-cell lymphoma of the stomach a pseudolymphoma, a lymphoma or an infectious disease?]. | 1994 | 7916746 | |
| effective treatment after failure of omeprazole plus amoxycillin to eradicate helicobacter pylori infection in peptic ulcer disease. | fifty patients with relapsing or complicated helicobacter pylori positive duodenal (n = 41) or gastric ulcer disease (n = 9) and failure of a combined treatment with omeprazole plus amoxycillin to eradicate h. pylori infection were re-treated with either oral triple therapy (bismuth subsalicylate, metronidazole, tetracycline) plus ranitidine [group i: n = 22] or high-dose omeprazole (40 mg b.d. to t.d.s.) plus amoxycillin (1 g t.d.s.) [group ii: n = 28]. | 1994 | 7918928 |
| short report: evaluation of helicobacter pylori eradication with bismuth sucralfate. | in a pilot study we have evaluated the clinical efficacy of bismuth sucralfate to eradicate h. pylori. ten consecutive patients with chronic dyspepsia and h. pylori associated gastritis were treated with bismuth sucralfate (220 mg bismuth per tablet, 4 tablets per day for 4 weeks). if a 14c urea breath test immediately after the medication was negative, a gastroscopy was performed one month later to obtain biopsies for culture and histological examination. | 1994 | 7918933 |
| helicobacter pylori infection. implications for ulcer therapy in older patients. | 1994 | 7919636 | |
| causal role of helicobacter pylori in peptic ulcer relapse. | helicobacter pylori has been shown to infect the gastric mucous layer of almost all patients with duodenal ulcer disease, as well as that of most patients with gastric ulcer disease. recent studies have suggested that the eradication of h. pylori affects the natural history of duodenal ulcer disease such that the rate of relapse decreases markedly. we evaluated the relationship between h. pylori infection and peptic ulcer relapse in a japanese population following a prospective study. seven of 1 ... | 1994 | 7921146 |
| helicobacter pylori: recent developments. | 1994 | 7921151 | |
| nsaid--induced gastroduodenal ulcers: exploring the silent dilemma. | nonsteroidal anti-inflammatory drugs (nsaids) are effective medications and are very commonly prescribed. they are used by a large proportion of elderly persons who are most prone to adverse events. nsaid gastropathy is the commonest side effect. the relative risk of adverse events is high, but the absolute risk for any individual patient is low. individualizing the risk/benefit ratio would lead to cost effective care. | 1994 | 7921152 |
| etiology and pathogenesis of peptic ulcer. | 1994 | 7921153 | |
| helicobacter pylori an chronic atrophic gastritis. | phenol red dye spraying endoscopy, in addition to a biopsy study, was employed for the determination of helicobacter pylori distribution on the gastric mucosa of 108 patients with no gross gastric findings. the sensitivity of this method was 100%, and its specificity was 84.6%. in patients with a c0 pattern of the fundic-pyloric (f-p) border, the h. pylori-positive rate was only 21%, but this increased with the spread of atrophic mucosa, to approximately 90%. however, in patients with an o3 patt ... | 1994 | 7921139 |
| is helicobacter pylori a cause of gastric cancer? an appraisal of the seroepidemiological evidence. | the epidemiological evidence linking helicobacter pylori infection to stomach cancer is reviewed here in ascending order of epidemiological strength. only those studies in which exposure to h. pylori was assessed by serology are considered. ecological studies or geographical correlation studies have revealed inconsistent results when the incidence or mortality rates of stomach cancer have been correlated with the prevalence rates of h. pylori infection. only those studies with a wide range in ga ... | 1994 | 7920213 |
| future directions for reductionistic research in gastric secretion and defense. | our theme centers on the complex processes that constitute and regulate the function of the gastric mucosa. although some investigators promote the critical importance of a given element, such as acid, blood flow, or mucus, it is clear that both gastric secretory function and mucosal defense and repair mechanisms are multifactorial and are regulated by redundant control circuits. while it is true that critical studies can be performed in vivo with intact mucosa, at the same time it is frequently ... | 1994 | 7921137 |
| identification of mixed genotypes in helicobacter pylori from gastric biopsy tissue by analysis of urease gene polymorphisms. | pcr-rflp analysis of the urease a and b genes was used to investigate the frequency that helicobacter pylori from gastric biopsy comprised genotypically distinct strains. seventy-five strains of h. pylori from 44 subjects from four geographically diverse locations were examined and 31 distinct urease gene profiles were identified. for most cultures, the totals of the rflp sizes were within 4% of the 2.41-kb pcr product. five strains were genomically more complex suggesting they contained a mixtu ... | 1994 | 7914791 |
| the role of helicobacter pylori infection in the pathogenesis of gastritis. | we conducted a prospective study to evaluate the relationship between h. pylori infection and gastritis in a japanese population. the study population consisted of 92 patients with endoscopically proven gastritis. biopsy specimens were taken from the gastric mucosa from the corpus and antrum according to the sydney system for the new classification of gastritis. h. pylori was histologically found in 84.3% of patients for mononuclear (mn) cell infiltration and in 88.1% of those positive for polym ... | 1994 | 7921138 |
| laparoscopic vagotomy: an operation for the 1990s? | 1994 | 7912490 | |
| high ige serum levels and "peptic" ulcers: clinical and functional approach. | the prevalence of high total ige serum levels was evaluated in 232 consecutive patients suffering from peptic ulcer. twenty-one percent of the patients presented total ige serum levels above 200 ku/l compared with the 5% found in a healthy control population (p < 0.004). similar prevalence was found in gastric and/or duodenal ulcers. no significant differences in the duration of the disease, smoking habits, familiarity for peptic ulcer, symptomatology and frequency of complications were observed ... | 1994 | 7912969 |
| serological, histological and polymerase chain reaction studies of helicobacter pylori infection in patients with gastric adenocarcinoma. | the association between helicobacter pylori (h. pylori) and gastric adenocarcinoma remains controversial. however, the prevalence of h. pylori infection in gastric adenocarcinoma varies with the method of detection used, eg, serology, histology, culture, and polymerase chain reaction. however, studies on gastric adenocarcinoma by these methods remain inconclusive. we compared the results of serology, histology, and polymerase chain reaction for detection of h. pylori infection in 12 patients wit ... | 1994 | 7915574 |
| effects of smoking and nicotine on the gastric mucosa: a review of clinical and experimental evidence. | epidemiological and experimental evidence have shown that nicotine has harmful effects on the gastric mucosa. the mechanisms by which cigarette smoking or nicotine adversely affect the gastric mucosa have not been fully elucidated. in this report, clinical and experimental data are reviewed. the effects of nicotine from smoking on gastric aggressive or defensive factors are discussed. nicotine potentiates gastric aggressive factors and attenuates defensive factors; it also increases acid and pep ... | 1994 | 7915701 |
| helicobacter pylori infection and coronary heart disease. | 1994 | 7915795 | |
| helicobacter pylori and the heart. | 1994 | 7912762 | |
| single and multiple strain colonization in patients with helicobacter pylori-associated gastritis: detection by macrorestriction dna analysis. | helicobacter pylori isolates from 18 patients were examined by macrorestriction dna analysis to determine whether > or = 2 strains can coexist in the human stomach. four biopsy samples from different sites in each patient's stomach were cultured, and 12-14 clones of h. pylori per patient were analyzed. dna of 15 of the 18 isolates was digestible: 12 by noti and 3 by nrui. within 14 of these digestible isolates, the patterns of all clones were identical. the isolate of 1 patient showed two digest ... | 1994 | 7913483 |
| topical antibiotics and gastric flora. | 1994 | 7917630 | |
| effect of eradication of helicobacter pylori on gastric epithelial cell proliferation. | helicobacter pylori is associated with b-type gastritis, duodenal ulcer disease, and possibly gastric carcinoma. the object of this study was to assess the effect of eradication of h. pylori infection on gastric epithelial cell proliferation. | 1994 | 7913636 |
| [antimicrobial sensitivity of helicobacter pyloriø]. | 1994 | 7914433 | |
| [a consensus on helicobacter pylori and gastroduodenal pathology]. | the current debate involving helicobacter pylori (h.p.) and its potential role as an etiological factor for some digestive diseases, as well as the recent discussion through different mass media of this bacterium, including the american n.i.h. consensus, have lead to the discussion of the h.p. problem, in order to clarify its real importance in acid-related diseases. thus we want, as gastroenterologists, to give an overview of the current status, so as to facilitate the general practitioner work ... | 1994 | 7918946 |
| [management of the peptic ulcer patient in the helicobacter pylori age]. | 1994 | 7914434 | |
| prospective, randomized study of h2-blocker and triple therapy for duodenal ulcer treatment and the eradication of helicobacter pylori. | the efficacy of h2-blocker and triple therapy in curing duodenal ulcer was compared and the contribution of the eradication of helicobacter pylori on ulcer remission was assessed. forty-two duodenal ulcer patients infected with h. pylori were randomized to receive either h2-blocker therapy with famotidine (n = 21) or triple therapy with bismuth, amoxicillin, and metronidazole (n = 21). all patients received treatment for four weeks. endoscopic evaluation of ulcer status and bacteriologic identif ... | 1994 | 7920074 |
| development of modern anti-ulcer drugs. | 1994 | 7914740 | |
| detection of microbial surface antigens that bind lewis(a) antigen. | there is evidence that the lewis(a) blood group antigen is one of the receptors for a number of potentially pathogenic microorganisms. to determine how widely distributed the microbial adhesins are that bind this antigen, anti-idiotypic antibodies produced against monoclonal anti-lewis(a) were used in coagglutination assays to screen a variety of species. the following were agglutinated: 7/7 strains of staphylococcus aureus; 10/19 (53%) strains of neisseria meningitidis; 8/13 (62%) strains of ha ... | 1994 | 7920460 |
| international symposium: helicobacter pylori: basic mechanisms to clinical cure amelia island, fl, usa, 3-6 november 1993. | 1994 | 7914786 | |
| helicobacter heilmannii (formerly gastrospirillum hominis) gastritis: an infection transmitted by animals? | the source of infection with helicobacter heilmannii (formerly gastrospirillum hominis), a relatively rare causative agent of gastritis in humans, is not clear. it has long been known that this organism occurs in the stomach of domestic animals and pets. | 1994 | 7886392 |
| therapeutic immunisation against helicobacter infection. | 1994 | 7908372 | |
| duodenal ulcer healing drugs. | 1994 | 7908373 | |
| duodenal ulcer healing drugs. | 1994 | 7908374 | |
| duodenal ulcer healing drugs. | 1994 | 7908375 | |
| [somatostatin--the decisive connection between helicobacter pylori gastritis and duodenal ulcer?]. | 1994 | 7908475 | |
| effects of omeprazole and lansoprazole on 24-hour intragastric ph in helicobacter pylori-positive volunteers. | the comparative effects of omeprazole and lansoprazole on gastric acidity in helicobacter pylori-positive subjects and the clearance of h. pylori are unknown. | 1994 | 7886393 |
| relapse of malt lymphoma associated with helicobacter pylori after antibiotic treatment. | 1994 | 7909113 | |
| omeprazole plus amoxicillin for cure of helicobacter pylori infection. factors influencing the treatment success. | omeprazole plus amoxicillin may cure helicobacter pylori infection. however, the published results vary rather widely, and the factors influencing the treatment success remain unclear. | 1994 | 7886394 |
| duodenal ulcer healing by eradication of helicobacter pylori without anti-acid treatment: randomised controlled trial. | randomised trials have shown that duodenal ulcers treated by h2 blockers heal faster if helicobacter pylori is eradicated concurrently. it remains unknown whether eradication of h pylori without suppression of acid-secretion, is sufficient to allow healing. 153 patients with h pylori infection and duodenal ulcer were randomised to receive either a 1-week course of bismuth subcitrate, tetracycline, and metronidazole (76), or omeprazole for 4 weeks with the same three-drug regimen for the first we ... | 1994 | 7906759 |
| comparison of labelling by bromodeoxyuridine, mib-1, and proliferating cell nuclear antigen in gastric mucosal biopsy specimens. | to compare proliferating cell nuclear antigen (pcna) and mib-1 with bromodeoxyuridine (brdu) pulse labelling, a specific marker of cell proliferation, in endoscopic gastric biopsy specimens. | 1994 | 7907613 |
| the rationale of acid suppression in the treatment of acid-related disease. | acid-related disorders such as gastric and duodenal ulcers and gastro-oesophageal reflux disease have a high prevalence. traditionally, acid suppression has proved to be the most effective means by which to heal these disorders, but relapse rates are high after cessation of treatment. recently, helicobacter pylori infection has been shown to modify several aspects of gastric function. eradication of h. pylori infection virtually abolishes duodenal ulcer recurrence, implicating this organism in t ... | 1994 | 7910047 |
| contribution of hla-dqa gene to host's response against helicobacter pylori. | 1994 | 7906783 | |
| blood group antigens and helicobacter pylori infections. | 1994 | 7906784 | |
| pcr-based restriction fragment length polymorphism typing of helicobacter pylori. | we applied a molecular typing approach for helicobacter pylori that uses restriction fragment length polymorphism (rflp) analyses of an 820-bp pcr-amplified portion of the urec gene in h. pylori. the pcr products were digested with restriction enzyme hhai, mboi, or msei, and the fragments generated were analyzed by agarose electrophoresis. among 25 independent clinical isolates, each showed a different pattern when a combination of the three rflp patterns was used. using this method, we studied ... | 1994 | 7908671 |
| suppression of human mononuclear cell response by helicobacter pylori: effects on isolated monocytes and lymphocytes. | helicobacter pylori colonization of the human gastric mucosa causes a long-term, not self-limiting inflammation, suggesting that the microbe has properties to protect itself against the host immune defence system. recently we were able to demonstrate that h. pylori suppresses the in vitro proliferative response of human peripheral blood mononuclear cells to antigens as well as to mitogens without affecting cell viability. the purpose of this study was to clarify which cell subsets of mononuclear ... | 1994 | 7909699 |
| canine-human transmission of gastrospirillum hominis. | we report electron microscopic evidence of transmission from a pet dog to a 12-year-girl of gastrospirillum hominis which caused gastric disease in both that was eradicable with treatment. | 1994 | 7911923 |
| fibrinogen: a link between chronic infection and coronary heart disease. | 1994 | 7911935 | |
| gene rearrangements, helicobacter pylori, and gastric malt lymphoma. | 1994 | 7911938 | |
| identification of helicobacter pylori in gastric specimens, gastric juice, saliva, and faeces of japanese patients. | 1994 | 7911939 | |
| effect of helicobacter pylori eradication on g-cell and d-cell density in children. | helicobacter pylori infection is associated with abnormalities in serum gastrin concentration, antral gastrin and somatostatin content, and d-cell density in adults. we have studied the effects of h pylori infection in children. we studied 13 children positive for h pylori and 7 negative children. the median antral somatostatin content was significantly lower in the positive than in the negative group (0.69 [range 0.35-0.91] vs 1.31 [0.73-1.67] ng/mg, p = 0.007). both antral and serum gastrin co ... | 1994 | 7909869 |
| helicobacter pylori eradication. | 1994 | 7908097 | |
| gastrin and somatostatin in helicobacter pylori infected antral mucosa. | helicobacter pylori infection is associated with increased meal stimulated gastrin secretion, but the reason for this is unknown. sequence specific radioimmunoassays were used to measure the concentration of alpha-amidated gastrin, the total progastrin product, and somatostatin in biopsy specimens of human antral mucosa. the antral concentrations of alpha-amidated gastrin and of total progastrin products were significantly higher in h pylori infected patients than in those not infected by this o ... | 1994 | 7911115 |
| [the pathogenesis of peptic ulcer]. | 1994 | 7900339 | |
| seroprevalence study of helicobacter pylori infection in patients with gastroduodenal diseases. | to investigate helicobacter pylori (h. pylori) infection in subjects with and without gastroduodenal diseases in taiwan, igg antibodies to h. pylori were examined in 136 healthy volunteers, 101 patients with non-ulcer dyspepsia, 122 gastric ulcers, 119 duodenal ulcers, and 161 gastric adenocarcinomas. the seropositivity was highest in duodenal ulcers (87.4%) (p < 0.001, as compared to healthy volunteers), followed by gastric ulcers (76.2%) (p < 0.01, as compared to healthy volunteers), but simil ... | 1994 | 7912582 |
| low dose, short duration therapy for the eradication of helicobacter pylori in patients with duodenal ulcer. | to study the efficacy and acceptability of low dose, short duration triple therapy in eradicating helicobacter pylori from patients with duodenal ulcer. | 1994 | 7906009 |
| duodenal ulcer treated with helicobacter pylori eradication: seven-year follow-up. | the long-term benefits of helicobacter pylori-eradication treatment (het) in h pylori-associated duodenal ulcer are unclear. we followed up patients with duodenal ulcers from a trial of h pylori eradication in 1985-86. 63 of 78 patients (81%) were reviewed clinically and had upper gastrointestinal endoscopy with gastric antral biopsy. of 35 patients previously rendered h pylori negative, 32 (92%) remained h pylori negative after 7.1 years (mean). all patients initially h pylori positive remained ... | 1994 | 7905095 |
| h pylori, gastric carcinoma, and malt lymphoma. | 1994 | 7905571 | |
| h pylori and gastric cancer. | 1994 | 7904707 | |
| coccoid helicobacter pylori not culturable in vitro reverts in mice. | an experimental rodent model was used to demonstrate the viability of the coccoid form of helicobacter pylori. concentrated suspensions were prepared for the two different morphologies: at 2 days incubation for the bacillary forms and at 20 days incubation for the "dormant" forms. the strains used for incubation were two fresh isolates from humans with duodenal ulceration, and two collection strains. five hundred microliters of culture (od550 = 5 mc farland) of helicobacter pylori with bacillary ... | 1994 | 7898382 |
| growth medium containing cyclodextrin and low concentration of horse serum for cultivation of helicobacter pylori. | the growth of helicobacter pylori, a gram-negative microaerophilic bacterium, is often difficult and requires complex media with the supplementation of 5% to 10% blood or blood derivatives. we have found that brucella broth supplemented with 1% heated horse serum and 0.1% beta-cyclodextrin supports the good growth of h. pylori. the degree of growth and production of urease and vacuolating cytotoxin in this medium were equal to those in the medium supplemented with 5% horse serum. this medium was ... | 1994 | 7898389 |
| how does helicobacter pylori cause duodenal ulcer disease: the bug, the host, or both? | helicobacter pylori infection is the most common cause of duodenal ulcer disease, yet duodenal ulcer is an uncommon outcome of h. pylori infection. we reviewed the possible explanations such as differences in the host or in the strain of h. pylori. host factors reviewed included genetic susceptibility to h. pylori infection and excess gastric acid secretion. the role of potential h. pylori virulence factors not present in all strains such as the caga gene and the results of other molecular metho ... | 1994 | 7881025 |
| aetiological factors of peptic ulcer: perspectives of epidemiological observations this century. | there are five known environmental, causative factors for peptic ulcer, namely, non-steroidal anti-inflammatory drugs (nsaid), helicobacter pylori infection, cigarette smoking, environmental stress and dietary habit. there have been six factual, epidemiological observations on peptic ulcer this century: the rise and fall of ulcer frequency in western societies; geographical variations in ulcer rates; in sex ratios; in duodenal: gastric ulcer ratios; and in placebo healing rates; and seasonal var ... | 1994 | 7881028 |
| clinical relevance of basic research in peptic ulcer disease. | historically, the interplay between basic research and clinical observation has been essential in the development of new therapies for peptic ulcer disease. that histamine is an important regulator of acid secretion emerged from basic research, followed by the clinical development and use of the h2-receptor antagonists. basic research contributed again by defining the importance of h+/k(+)-atpase in acid secretion, resulting in a new class of useful antisecretory agents. basic studies also gave ... | 1994 | 7881029 |
| [healing quality and recurrence of ulcer diseases]. | 1994 | 7882737 | |
| helicobacter pylori phenotypes associated with peptic ulceration. | persistent infection with helicobacter pylori occurs in a large percentage of the population, particularly in countries with low socioeconomic status. such infection nearly always produces chronic gastric inflammation, although in most individuals it is clinically silent and only a minority of infected persons develop h. pylori-induced peptic ulcers. in this review, the hypothesis that diversity among h. pylori strains is at least partly responsible for the observed variability in the outcome of ... | 1994 | 7863235 |
| helicobacter pylori in peptic ulcer disease. proceedings of a symposium. brussels, belgium, 23 september 1993. | 1994 | 7863236 | |
| inhibition of helicobacter pylori urease activity by hydroxamic acid derivatives. | helicobacter pylori (hp) produces strong urease [ec 3.5.1.5], which is considered to play a role in the pathogenesis of gastritis and peptic ulcers. inhibitions against this enzyme have been studied with hydroxamic acid (hxa) derivatives of aliphatic or aromatic carboxylic acids, amino acids and dipeptides. a number of hxas potently inhibited the urease (i50 values were near the order of 10(-6)m), and h-ile-gly-nhoh (i50 = 0.20 x 10(-6)m) was the most potent inhibitor among the derivatives. hp u ... | 1994 | 7874052 |
| [sensitivity of gastric parietal cells to histamine after administration of enprostil and ranitidine during 4 weeks in healthy subjects]. | parietal cell sensitivity is increased in patients with active duodenal ulcer. it has been shown to increase in healthy volunteers after a 4-week treatment with h2-receptor blockers. metaanalyses of therapeutic trials have indicated that time to first relapse was longer after ulcer healing with prostaglandins (pg) than after healing with h2-receptor blockers, which might be due to a different effect of the two treatments on parietal cell sensitivity. objectives--to study, in healthy volunteers, ... | 1994 | 7875435 |
| lymphocytic gastritis, gastric adenocarcinoma, and primary gastric lymphoma. | a series of primary gastric lymphomas and adenocarcinomas was reviewed to assess the prevalence of lymphocytic gastritis in these conditions. lymphocytic gastritis was more prevalent in patients with gastric adenocarcinoma (16 of 130 cases; 12.3%) and primary gastric lymphoma (six of 45 cases; 13.7%) than in unselected patients undergoing endoscopy (0.83-2.5%). this suggests that these two disparate gastric tumours may share an immunological dysfunction or a common pathogenesis, and this is of i ... | 1994 | 7876391 |
| gastric heterotopia in the upper esophagus (inlet patch) in endoscopic surveys in northern china. | upper esophageal gastric heterotopia (inlet patch) has not been reported in endoscopic series from china. we describe the occurrence of endoscopically and histologically typical inlet patches in two endoscopic surveys of asymptomatic adults in northern china. because rapid endoscopic protocols were used, the 0.3-0.4% prevalence of inlet patch in these surveys probably represents a minimum figure for adults in this population. | 1994 | 7876515 |
| treatment for helicobacter pylori infection. | 1994 | 7876524 | |
| epithelial cytotoxicity, immune responses, and inflammatory components of helicobacter pylori gastritis. | to clarify the mechanisms of the gastric mucosal immune--inflammatory response to helicobacter pylori infection, surgical and biopsy specimens from asymptomatic uninfected, gastritis-free individuals and from h. pylori-positive ulcer patients with chronic gastritis were investigated using light and electron microscopy. activation of the antigen-transporting endocytic--endosomal system, enhanced expression of the antigen-processing enzyme cathepsin e and de novo expression of antigen-presenting h ... | 1994 | 7863237 |
| comparative observations on the types of atrophic gastritis and biopsy pathology of gastric mucosa. | 300 cases of chronic atrophic gastritis were classified into 3 types of qi-deficiency of spleen and stomach, yang-deficiency of spleen and stomach, and yin-deficiency of spleen and stomach according to syndrome differentiation of traditional chinese medicine. the biopsy specimens of gastric mucosa were examined histopathologically and for the presence of pyloric spirobacteria. the results showed that the type of yin-deficiency was the most serious in the degree of pathologic changes, or the glan ... | 1994 | 7877344 |
| the role of the local immune response in the pathogenesis of peptic ulcer formation. | mucosal immune responses are designed to provide local protection against infection, without inducing excessive amounts of inflammation that would alter epithelial integrity or function. it has become clear that the epithelium not only serves as a barrier to exclude pathogens, but also initiates host responses to infection. gastric epithelial cells infected with helicobacter pylori can respond within hours to produce inflammatory mediators that recruit and activate neutrophils. the gastric epith ... | 1994 | 7863238 |
| the role of omeprazole and antibiotic combinations in the eradication of helicobacter pylori--an update. | when omeprazole is given with an appropriate antibiotic, a high rate of helicobacter pylori eradication can be achieved. to date, most studies have used omeprazole and amoxycillin, and an analysis of the results suggests that, at present, the most effective treatment regimen comprises omeprazole, 20 mg twice daily, and amoxycillin, 1 g twice daily, for 14 days. this regimen provides an eradication rate of about 85%. results using omeprazole plus bismuth or tetracycline have been disappointing; h ... | 1994 | 7863239 |
| long-term consequences of helicobacter pylori eradication. | long-term infection with helicobacter pylori could potentially lead to asymptomatic chronic gastritis, chronic dyspepsia, duodenal ulcer disease, gastric ulcer disease, or gastric malignancy, including both adenocarcinoma and b-cell lymphoma. currently, the two most important indications for eradication of this bacterium are proven h. pylori-associated duodenal or gastric ulcer disease. many studies have shown that successful eradication of h. pylori dramatically reduces the rate of duodenal ulc ... | 1994 | 7863240 |
| [helicobacter pylori in patients with gastroduodenal pathology at a young age]. | 1994 | 7879558 | |
| helicobacter pylori infection in children with recurrent abdominal pain. | forty-eight patients with recurrent abdominal pain were studied endoscopically for the presence of gastritis and helicobacter pylori infection. fifteen of these children had histological evidence of gastritis with eight of them having concomitant h. pylori infection. the majority of those with h. pylori infection had severe degrees of acute following chronic gastritis. | 1994 | 7880086 |
| treatment strategies for symptom resolution, healing, and helicobacter pylori eradication in duodenal ulcer patients. | the introduction of anti-helicobacter pylori therapy has increased the number of options available for the management of patients with duodenal ulcer disease. the aim of this paper is to summarize current knowledge and use it to form a strategy relevant to the management of patients with duodenal ulcer disease. four key aspects are addressed. (i) selection of duodenal ulcer patients for anti-h. pylori treatment. as the subgroup of patients who will develop minor disease activity in the future ca ... | 1994 | 7863241 |
| future research in peptic ulcer disease. | for the past 10 years, research into peptic ulcer disease has focused on the surprising suggestion that gastritis and peptic ulcers may be caused by the bacterium helicobacter pylori. however, the time has now come to reappraise research directions, as a causal link has been established, and even the most ardent sceptics now accept that h. pylori infection is the major factor in most cases of peptic ulcer disease. as with any established microbial disease, we need to understand the epidemiology ... | 1994 | 7863242 |
| helicobacter pylori eradication: the rational treatment for peptic ulcer disease--chairmen's conclusion. | 1994 | 7863243 |